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[PMID]:28420530
[Au] Autor:Schmidt A; Schreiner MG; Mayer HK
[Ad] Endereço:Department of Food Science and Technology, Food Chemistry Laboratory, BOKU - University of Natural Resources and Life Sciences Vienna, Muthgasse 11, A-1190 Vienna, Austria.
[Ti] Título:Rapid determination of the various native forms of vitamin B and B in cow's milk using ultra-high performance liquid chromatography.
[So] Source:J Chromatogr A;1500:89-95, 2017 Jun 02.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:As the formation of pyridoxal phosphate, the active cofactor of vitamin B , is dependent on riboflavin 5-phosphate, we propose a fast and simple ultra-high performance liquid chromatography method for the simultaneous determination of the native B vitamers pyridoxal, pyridoxine, pyridoxamine, their mono phosphorus esters and 4-pyridoxic acid as well as vitamin B as riboflavin and its phosphorus ester riboflavin 5-phosphate in milk. Separation was achieved under 6.0min by reversed-phase and pH gradient elution. Sample preparation was optimized regarding various acids and pH levels. Changes in those parameters led to significant deviations of sample matrix breakdown efficiency. The optimized method was then validated regarding specificity, accuracy, precision, linearity, range, detection and quantification limits. As the method performed satisfactory, is was used to study commercial liquid cow's milk (n=31), regarding effects of the employed preservation technique (pasteurization, extended shelf-life, ultra-high temperature) on the composition and content of B and B vitamers. In cow's milk, vitamin B mostly consists of pyridoxal and its phosphate ester, with pyridoxal phosphate being the bulk component. The catabolite of the vitamin B metabolism, 4-pyridoxic acid was present in significant amounts in all studied samples, with up to 2.69µmolL . Vitamin B was present as riboflavin and its phosphate ester up to 12.86µmolL .
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Leite/química
Riboflavina/análise
Vitamina B 6/análise
[Mh] Termos MeSH secundário: Animais
Bovinos
Seres Humanos
Piridoxal/análise
Fosfato de Piridoxal/análise
Piridoxamina/análise
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
3THM379K8A (Pyridoxal); 5V5IOJ8338 (Pyridoxal Phosphate); 6466NM3W93 (Pyridoxamine); 8059-24-3 (Vitamin B 6); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


  2 / 953 MEDLINE  
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[PMID]:28390667
[Au] Autor:Wang Q; He XM; Chen X; Zhu GT; Wang RQ; Feng YQ
[Ad] Endereço:Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
[Ti] Título:Pyridoxal 5'-phosphate mediated preparation of immobilized metal affinity material for highly selective and sensitive enrichment of phosphopeptides.
[So] Source:J Chromatogr A;1499:30-37, 2017 May 26.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phosphorylation is a crucial post-translational modification, which plays pivotal roles in various biological processes. Analysis of phosphopeptides by mass spectrometry (MS) is intractable on account of their low stoichiometry and the ion suppression from non-phosphopeptides. Thus, enrichment of phosphopeptides before MS analysis is indispensable. In this work, we employed pyridoxal 5'-phosphate (PLP), as an immobilized metal affinity chromatography (IMAC) ligand for the enrichment of phosphopeptides. PLP was grafted onto several substrates such as silica (SiO ), oxidized carbon nanotube (OCNT) and silica coated magnetic nanoparticles (Fe O @SiO ). Then the metal ions Fe , Ga and Ti were incorporated for the selective enrichment of phosphopeptides. It is indicated that Fe O @SiO -PLP-Ti has a superior selectivity towards phosphopeptides under as much as 1000-fold interferences of non-phosphopeptides. Further, Fe O @SiO -PLP-Ti exhibited high efficiency in selective enrichments of phosphopeptides from complex biological samples, including human serum and tryptic digested non-fat milk. Finally, Fe O @SiO -PLP-Ti was successfully employed in the sample pretreatment for profiling phosphopeptides in a tryptic digest of rat brain proteins. Our experimental results evidenced a great potential of this new chelator-based material in phosphoproteomics study.
[Mh] Termos MeSH primário: Cromatografia de Afinidade/métodos
Fosfatos/química
Fosfopeptídeos/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Íons
Magnetismo
Espectrometria de Massas
Metais
Nanopartículas/análise
Fosfopeptídeos/química
Processamento de Proteína Pós-Traducional
Piridoxal/química
Ratos
Dióxido de Silício/química
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ions); 0 (Metals); 0 (Phosphates); 0 (Phosphopeptides); 3THM379K8A (Pyridoxal); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE


  3 / 953 MEDLINE  
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[PMID]:28275126
[Au] Autor:Gylling B; Myte R; Schneede J; Hallmans G; Häggström J; Johansson I; Ulvik A; Ueland PM; Van Guelpen B; Palmqvist R
[Ad] Endereço:Departments of Medical Biosciences, Pathology.
[Ti] Título:Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status.
[So] Source:Am J Clin Nutr;105(4):897-904, 2017 Apr.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Higher plasma concentrations of the vitamin B-6 marker pyridoxal 5'-phosphate (PLP) have been associated with reduced colorectal cancer (CRC) risk. Inflammatory processes, including vitamin B-6 catabolism, could explain such findings. We investigated 3 biomarkers of vitamin B-6 status in relation to CRC risk. This was a prospective case-control study of 613 CRC cases and 1190 matched controls nested within the Northern Sweden Health and Disease Study ( = 114,679). Participants were followed from 1985 to 2009, and the median follow-up from baseline to CRC diagnosis was 8.2 y. PLP, pyridoxal, pyridoxic acid (PA), 3-hydroxykynurenine, and xanthurenic acids (XAs) were measured in plasma with the use of liquid chromatography-tandem mass spectrometry. We calculated relative and absolute risks of CRC for PLP and the ratios 3-hydroxykynurenine:XA (HK:XA), an inverse marker of functional vitamin B-6 status, and PA:(PLP + pyridoxal) (PAr), a marker of inflammation and oxidative stress and an inverse marker of vitamin B-6 status. Plasma PLP concentrations were associated with a reduced CRC risk for the third compared with the first quartile and for PLP sufficiency compared with deficiency [OR: 0.60 (95% CI: 0.44, 0.81) and OR: 0.55 (95% CI: 0.37, 0.81), respectively]. HK:XA and PAr were both associated with increased CRC risk [OR: 1.48 (95% CI: 1.08, 2.02) and OR: 1.50 (95% CI: 1.10, 2.04), respectively] for the fourth compared with the first quartile. For HK:XA and PAr, the findings were mainly observed in study participants with <10.5 y of follow-up between sampling and diagnosis. Vitamin B-6 deficiency as measured by plasma PLP is associated with a clear increase in CRC risk. Furthermore, our analyses of novel markers of functional vitamin B-6 status and vitamin B-6-associated oxidative stress and inflammation suggest a role in tumor progression rather than initiation.
[Mh] Termos MeSH primário: Neoplasias Colorretais/etiologia
Cinurenina/análogos & derivados
Estado Nutricional
Deficiência de Vitamina B 6/complicações
Vitamina B 6/sangue
Xanturenatos/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores/sangue
Estudos de Casos e Controles
Neoplasias Colorretais/sangue
Neoplasias Colorretais/prevenção & controle
Feminino
Seres Humanos
Inflamação/sangue
Inflamação/etiologia
Cinurenina/sangue
Masculino
Meia-Idade
Razão de Chances
Estresse Oxidativo
Estudos Prospectivos
Piridoxal/sangue
Fosfato de Piridoxal/sangue
Ácido Piridóxico/sangue
Suécia
Deficiência de Vitamina B 6/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Xanthurenates); 27723548JL (3-hydroxykynurenine); 343-65-7 (Kynurenine); 3THM379K8A (Pyridoxal); 58LAB1BG8J (xanthurenic acid); 5K18793O8D (Pyridoxic Acid); 5V5IOJ8338 (Pyridoxal Phosphate); 8059-24-3 (Vitamin B 6)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.139337


  4 / 953 MEDLINE  
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[PMID]:28040557
[Au] Autor:Akiyama T; Akiyama M; Hayashi Y; Shibata T; Hanaoka Y; Toda S; Imai K; Hamano SI; Okanishi T; Yoshinaga H; Kobayashi K
[Ad] Endereço:Department of Child Neurology, Okayama University Hospital, Okayama, Japan. Electronic address: takiyama@okayama-u.ac.jp.
[Ti] Título:Measurement of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children.
[So] Source:Clin Chim Acta;466:1-5, 2017 Mar.
[Is] ISSN:1873-3492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in the cerebrospinal fluid (CSF) of children and to investigate the effect of age, sex, epilepsy, and anti-epileptic drug (AED) therapy on these vitamers. METHODS: CSF samples prospectively collected from 116 pediatric patients were analyzed. PLP, PL, and PA were measured using high-performance liquid chromatography with fluorescence detection, using pre-column derivatization by semicarbazide. Effects of age, sex, epilepsy, and AEDs on these vitamers and the PLP/PL ratio were evaluated using multiple linear regression models. RESULTS: The PLP, PL, and PA concentrations were correlated negatively with age and the PLP/PL ratio was correlated positively with age. Multiple regression analysis revealed that the presence of epilepsy was associated with lower PLP concentrations and PLP/PL ratios but sex and AED therapy had no influence on these values. The observed ranges of these vitamers in epileptic and non-epileptic patients were demonstrated. CONCLUSIONS: We showed the age dependence of PLP and PL in CSF from pediatric patients. Epileptic patients had lower PLP concentrations and PLP/PL ratios than non-epileptic patients, but it is unknown whether this is the cause, or a result, of epilepsy.
[Mh] Termos MeSH primário: Epilepsia/líquido cefalorraquidiano
Fosfato de Piridoxal/líquido cefalorraquidiano
Piridoxal/líquido cefalorraquidiano
Ácido Piridóxico/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Fatores Etários
Criança
Cromatografia Líquida de Alta Pressão
Epilepsia/etiologia
Feminino
Seres Humanos
Modelos Lineares
Masculino
Estudos Prospectivos
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3THM379K8A (Pyridoxal); 5K18793O8D (Pyridoxic Acid); 5V5IOJ8338 (Pyridoxal Phosphate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170826
[Lr] Data última revisão:
170826
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE


  5 / 953 MEDLINE  
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[PMID]:27940235
[Au] Autor:Bothra S; Upadhyay Y; Kumar R; Ashok Kumar SK; Sahoo SK
[Ad] Endereço:Department of Applied Chemistry, SV National Institute of Technology (SVNIT), Surat 395007, India.
[Ti] Título:Chemically modified cellulose strips with pyridoxal conjugated red fluorescent gold nanoclusters for nanomolar detection of mercuric ions.
[So] Source:Biosens Bioelectron;90:329-335, 2017 Apr 15.
[Is] ISSN:1873-4235
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One-pot approach was adopted for the synthesis of highly luminescent near-infrared (NIR)-emitting gold nanoclusters (AuNCs) using bovine serum albumin (BSA) as a protecting agent. The vitamin B cofactor pyridoxal was conjugated with the luminescent BSA-AuNCs through the free amines of BSA and then employed for the nanomolar detection of Hg in aqueous medium via selective fluorescence quenching of AuNCs. This nano-assembly was successfully applied for the real sample analysis of Hg in fish, tap water and river water. The study also presents chemically-modified cellulosic paper strips with the pyridoxal conjugated BSA-AuNCs for detecting Hg ion up to 1nM.
[Mh] Termos MeSH primário: Técnicas Biossensoriais
Mercúrio/isolamento & purificação
Nanopartículas Metálicas/química
Poluentes Químicos da Água/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Bovinos
Celulose/química
Peixes
Análise de Alimentos
Ouro/química
Mercúrio/química
Piridoxal/química
Soroalbumina Bovina/química
Espectrometria de Fluorescência
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 27432CM55Q (Serum Albumin, Bovine); 3THM379K8A (Pyridoxal); 7440-57-5 (Gold); 9004-34-6 (Cellulose); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  6 / 953 MEDLINE  
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[PMID]:27918442
[Au] Autor:Sobczyk L; Chudoba D; Tolstoy PM; Filarowski A
[Ad] Endereço:Faculty of Chemistry, University of Wroclaw, 14 F. Joliot-Curie Str., 50-383 Wroclaw, Poland. lucjan.sobczyk@chem.uni.wroc.pl.
[Ti] Título:Some Brief Notes on Theoretical and Experimental Investigations of Intramolecular Hydrogen Bonding.
[So] Source:Molecules;21(12), 2016 Dec 02.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A review of selected literature data related to intramolecular hydrogen bonding in -hydroxyaryl Schiff bases, -hydroxyaryl ketones, -hydroxyaryl amides, proton sponges and -hydroxyaryl Mannich bases is presented. The paper reports on the application of experimental spectroscopic measurements (IR and NMR) and quantum-mechanical calculations for investigations of the proton transfer processes, the potential energy curves, tautomeric equilibrium, aromaticity etc. Finally, the equilibrium between the intra- and inter-molecular hydrogen bonds in amides is discussed.
[Mh] Termos MeSH primário: Amidas/química
Ligações de Hidrogênio
Cetonas/química
Bases de Mannich/química
Teoria Quântica
Bases de Schiff/química
[Mh] Termos MeSH secundário: Acetofenonas/química
Espectroscopia de Ressonância Magnética
Prótons
Piridoxal/química
Salicilamidas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Acetophenones); 0 (Amides); 0 (Ketones); 0 (Mannich Bases); 0 (Protons); 0 (Salicylamides); 0 (Schiff Bases); 3THM379K8A (Pyridoxal); EM8BM710ZC (salicylamide); RK493WHV10 (acetophenone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


  7 / 953 MEDLINE  
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[PMID]:27830400
[Au] Autor:Huang JY; Butler LM; Midttun Ø; Koh WP; Ueland PM; Wang R; Jin A; Gao YT; Yuan JM
[Ad] Endereço:Division of Cancer Control and Population Science, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue - Suite 4C, Pittsburgh, PA, 15232, USA.
[Ti] Título:Serum B vitamers (pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case-control studies in Asian populations.
[So] Source:Cancer Causes Control;27(12):1447-1456, 2016 Dec.
[Is] ISSN:1573-7225
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vitamin B is an important enzymatic cofactor in pathways relevant for the development of pancreatic cancer. In order to evaluate vitamin B as a preventive factor for pancreatic cancer, a biomarker approach is needed to overcome the limitations inherent in self-reported dietary information. METHODS: To determine whether levels of serum B vitamers, including pyridoxal 5'-phosphate (PLP), pyridoxal (PL), 4-pyridoxic acid (PA), and the PA/(PLP + PL) ratio (PAr), were associated with risk of pancreatic cancer, two nested case-control studies of 187 incident pancreatic cancer cases and 258 individually matched controls were conducted within two prospective cohorts of 81,501 participants in Shanghai, China, and Singapore. PLP, PL, and PA were quantified in pre-diagnostic serum samples. Odds ratios and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for potential confounders. RESULTS: The median (5th-95th percentiles) concentrations of serum PLP among control subjects of the Shanghai and Singapore cohorts were 25.7 (10.0-91.7) nmol/L and 58.1 (20.8-563.0) nmol/L, respectively. In pooled analyses, high serum PLP was associated with a reduced risk of pancreatic cancer (P for trend = 0.048); the adjusted odds ratio for the highest category of PLP (>52.4 nmol/L) was 0.46 (95% CI 0.23, 0.92) compared to vitamin B deficiency (<20 nmol/L). No associations were found for serum PL, PA, or PAr with pancreatic cancer risk. CONCLUSIONS: Higher concentrations of PLP may protect against the development of pancreatic cancer. The protective effect may be more apparent in populations with low concentrations of circulating vitamin B .
[Mh] Termos MeSH primário: Neoplasias Pancreáticas/sangue
Fosfato de Piridoxal/sangue
Piridoxal/sangue
Ácido Piridóxico/sangue
[Mh] Termos MeSH secundário: Idoso
Grupo com Ancestrais do Continente Asiático
Biomarcadores Tumorais/sangue
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Neoplasias Pancreáticas/epidemiologia
Estudos Prospectivos
Fatores de Risco
Singapura/epidemiologia
Vitamina B 6/sangue
Complexo Vitamínico B/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 12001-76-2 (Vitamin B Complex); 3THM379K8A (Pyridoxal); 5K18793O8D (Pyridoxic Acid); 5V5IOJ8338 (Pyridoxal Phosphate); 8059-24-3 (Vitamin B 6)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE


  8 / 953 MEDLINE  
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[PMID]:27693733
[Au] Autor:Busic V; Katalinic M; Sinko G; Kovarik Z; Gaso-Sokac D
[Ad] Endereço:Josip Juraj Strossmayer University of Osijek, Faculty of Food Technology, Kuhaceva 20, HR-31000 Osijek, Croatia.
[Ti] Título:Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds.
[So] Source:Toxicol Lett;262:114-122, 2016 Nov 16.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Organophosphorus (OP) nerve agents (sarin, tabun VX and soman) inhibit the enzyme acetylcholinesterase (AChE, EC 3.1.1.7) by binding to its active site while preventing neurotransmission in the cholinergic synapses. The protection and treatment of this kind of poisoning are still a challenge as we are yet to discover an antidote that would be effective in all cases of poisoning. To aid the search for more efficient antidotes, we evaluated the ability of nine pyridoxal oxime derivatives, prepared by a novel synthetic pathway, to reactivate recombinant human AChE and the related purified human plasma butyrylcholinesterase (BChE, EC 3.1.1.8) inhibited by VX, tabun and paraoxon. Oximes are derivatives of vitamin B6 bearing a phenacyl moiety attached to the quaternary nitrogen atom and having various substituents on the phenyl ring. As the results have shown, the tested oximes were in general more efficient in the reactivation of OP-inhibited BChE than AChE. The highest observed rate was in the case of VX-inhibited BChE reactivation, where k was 0.0087min and the reactivation maximum of 90% was achieved within 5h. The cholinesterases displayed a binding affinity for these derivatives in a µmolar range no matter the substituent on their rings which was in accordance with the molecular modelling results showing a similar binding pattern for all oximes within the active site of both AChE and BChE. Such a positioning reveals also that hydroxy and a metoxy substituents at the vicinity of the oxime moiety present a possible steric hindrance explaining the reactivation results.
[Mh] Termos MeSH primário: Antídotos/farmacologia
Inibidores da Colinesterase/farmacologia
Reativadores da Colinesterase/farmacologia
Compostos Organofosforados/farmacologia
Piridoxal/análogos & derivados
[Mh] Termos MeSH secundário: Acetilcolinesterase/química
Acetilcolinesterase/metabolismo
Antídotos/metabolismo
Butirilcolinesterase/química
Butirilcolinesterase/metabolismo
Substâncias para a Guerra Química/farmacologia
Seres Humanos
Modelos Moleculares
Piridoxal/metabolismo
Piridoxal/farmacologia
Proteínas Recombinantes
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidotes); 0 (Chemical Warfare Agents); 0 (Cholinesterase Inhibitors); 0 (Cholinesterase Reactivators); 0 (Organophosphorus Compounds); 0 (Recombinant Proteins); 3THM379K8A (Pyridoxal); 708-08-7 (pyridoxaloxime); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


  9 / 953 MEDLINE  
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[PMID]:27302825
[Au] Autor:Assimos DG
[Ti] Título:Re: Pyridoxamine and Pyridoxal are More Effective than Pyridoxine in Rescuing Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I.
[So] Source:J Urol;195(4 Pt 1):1170-1, 2016 04.
[Is] ISSN:1527-3792
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hiperoxalúria Primária
Piridoxamina
[Mh] Termos MeSH secundário: Alanina
Seres Humanos
Hiperoxalúria
Piridoxal
Piridoxina
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
3THM379K8A (Pyridoxal); 6466NM3W93 (Pyridoxamine); KV2JZ1BI6Z (Pyridoxine); OF5P57N2ZX (Alanine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE


  10 / 953 MEDLINE  
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[PMID]:27169836
[Au] Autor:Ulvik A; Pedersen ER; Svingen GF; McCann A; Midttun Ø; Nygård O; Ueland PM
[Ad] Endereço:Bevital AS, Bergen, Norway; arve.ulvik@farm.uib.no.
[Ti] Título:Vitamin B-6 catabolism and long-term mortality risk in patients with coronary artery disease.
[So] Source:Am J Clin Nutr;103(6):1417-25, 2016 Jun.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Low vitamin B-6 status has been related to increased risk of coronary artery disease (CAD), which is a condition that is associated with inflammation. The most common status marker, plasma pyridoxal 5'-phosphate (PLP), decreases during inflammation; therefore, causal relations are uncertain. OBJECTIVE: We evaluated the vitamin B-6 biomarkers PLP, pyridoxal, and pyridoxic acid (PA) and the pyridoxic acid:(pyridoxal + PLP) ratio (PAr), a proposed marker of vitamin B-6 catabolism during activated cellular immunity, as predictors of mortality. DESIGN: Associations with risks of long-term all-cause mortality and cardiovascular mortality were evaluated with the use of Cox regression in patients who were undergoing elective coronary angiography for suspected stable angina pectoris (SAP) (n = 4131) and an independent cohort of patients who were hospitalized for acute myocardial infarction (AMI) (n = 3665). RESULTS: Plasma PLP (AMI patients only) and PA predicted all-cause mortality in models that were adjusted for established risk predictors, but associations were attenuated or nonsignificant after additional adjustment for inflammatory markers. PAr was correlated with biomarkers of inflammation (Pearson's r ≥ 0.37) and predicted all-cause mortality and cardiovascular mortality after adjustment for established risk predictors. In SAP patients, PAr had greater predictive strength than did current smoking, diabetes, hypertension, apolipoproteins, or C-reactive protein. PAr provided multiadjusted HRs per SD of 1.45 (95% CI: 1.30, 1.63) and 1.31 (95% CI: 1.21, 1.41) in SAP and AMI patients, respectively. In both cohorts, PAr was a particularly strong predictor of all-cause mortality for patients with no previous CAD history (P-interaction ≤ 0.04). CONCLUSION: PAr may capture unique aspects of inflammatory activation and thus provide new insights into disease mechanisms that may aid in identifying patients at increased risk of future fatal events.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Doença da Artéria Coronariana/sangue
Doença da Artéria Coronariana/mortalidade
Vitamina B 6/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Proteína C-Reativa/análise
Feminino
Seres Humanos
Inflamação/sangue
Masculino
Meia-Idade
Mortalidade
Infarto do Miocárdio/sangue
Piridoxal/sangue
Fosfato de Piridoxal/sangue
Ácido Piridóxico/sangue
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 3THM379K8A (Pyridoxal); 5K18793O8D (Pyridoxic Acid); 5V5IOJ8338 (Pyridoxal Phosphate); 8059-24-3 (Vitamin B 6); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160513
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.115.126342



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