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[PMID]:28885978
[Au] Autor:Datta S; He G; Tomilov A; Sahdeo S; Denison MS; Cortopassi G
[Ad] Endereço:Department of Molecular Bioscience, School of Veterinary Medicine, University of California , Davis, Davis, California, USA.
[Ti] Título: Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride.
[So] Source:Environ Health Perspect;125(8):087015, 2017 08 22.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Quaternary ammonium salts (QUATS), such as cetylpyridinium chloride (CPC) and benzalkonium chloride (BAK), are frequently used in antiseptic formulations, including toothpastes, mouthwashes, lozenges, throat and nasal sprays, and as biocides. Although in a recent ruling, the U.S. Food and Drug Administration (FDA) banned CPC from certain products and requested more data on BAK's efficacy and safety profile, QUATS, in general, and CPC and BAK, in particular, continue to be used in personal health care, food, and pharmaceutical and cleaning industries. OBJECTIVES: We aimed to assess CPC's effects on mitochondrial toxicity and endocrine disruption . METHOD: Mitochondrial O consumption and adenosine triphosphate (ATP) synthesis rates of osteosarcoma cybrid cells were measured before and after CPC and BAK treatment. Antiestrogenic effects of the compounds were measured by a luciferase-based assay using recombinant human breast carcinoma cells (VM7Luc4E2, ERalpha-positive). RESULTS: CPC inhibited both mitochondrial O consumption [half maximal inhibitory concentration (IC ): 3.8µM] and ATP synthesis (IC : 0.9µM), and additional findings supported inhibition of mitochondrial complex 1 as the underlying mechanism for these effects. In addition, CPC showed concentration-dependent antiestrogenic activity half maximal effective concentration [(EC ): 4.5µM)]. BAK, another antimicrobial QUATS that is structurally similar to CPC, and the pesticide rotenone, a known complex 1 inhibitor, also showed mitochondrial inhibitory and antiestrogenic effects. In all three cases, there was overlap of the antiestrogenic activity with the mitochondrial inhibitory activity. CONCLUSIONS: Mitochondrial inhibition occurred at a CPC concentration that may be relevant to human exposures. The antiestrogenic activity of CPC, BAK, rotenone, and triclosan may be related to their mitochondrial inhibitory activity. Our findings support the need for additional research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, including CPC and BAK. https://doi.org/10.1289/EHP1404.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/toxicidade
Cetilpiridínio/toxicidade
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Seres Humanos
Mitocôndrias/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); CUB7JI0JV3 (Cetylpyridinium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1289/EHP1404


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[PMID]:28778186
[Au] Autor:Hiza H; Doulla B; Sasamalo M; Hella J; Kamwela L; Mhimbira F; Reither K; Gagneux S; Jugheli L; Fenner L
[Ad] Endereço:Ifakara Health Institute, Bagamoyo, Tanzania.
[Ti] Título:Preservation of sputum samples with cetylpyridinium chloride (CPC) for tuberculosis cultures and Xpert MTB/RIF in a low-income country.
[So] Source:BMC Infect Dis;17(1):542, 2017 Aug 04.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Culture contamination with environmental bacteria is a major challenge in tuberculosis (TB) laboratories in hot and humid climate zones. We studied the effect of cetylpyridinium chloride (CPC) preservation on culture results and performance of Xpert MTB/RIF. METHODS: Consecutive sputum samples from microscopy smear-positive TB patients were collected. Two-hundred samples were equally split in two aliquots, one aliquot was treated with CPC and stored at ambient temperature for 7 days. The second aliquot was immediately processed. Samples were decontaminated for 20, 15 or 10 min, and subsequently cultured on Löwenstein-Jensen medium. Furthermore, 50 samples were stored for 7, 14 and 21 days, and 100 CPC-pretreated samples tested by Xpert MTB/RIF. RESULTS: CPC pretreated samples showed a higher culture yield compared to non-treated sputum samples across all decontamination times: 94% vs. 73% at 10 min (p = 0.01), 94% vs. 64% at 15 min (p = 0.004), and 90% vs. 52% at 20 min (p < 0.001). The quantitative culture grading was consistently higher in CPC treated compared to non-CPC treated samples. The proportion of contaminated cultures was lower in CPC pretreated samples across all decontamination times (range 2-6%) compared to non-CPC treated samples (15-16%). For storage times of CPC treated samples of 7, 14, and 21 days, 84, 86, and 84% of the respective cultures were positive. Of 91 CPC treated samples with a positive culture, 90 were also Xpert MTB/RIF positive. CONCLUSIONS: CPC increases culture yield, decreases the proportion of contamination, and does not alter the performance of Xpert MTB/RIF.
[Mh] Termos MeSH primário: Técnicas Bacteriológicas/métodos
Cetilpiridínio/química
Mycobacterium tuberculosis/genética
Manejo de Espécimes/métodos
Escarro/microbiologia
[Mh] Termos MeSH secundário: Países em Desenvolvimento
Seres Humanos
Microscopia/métodos
Mycobacterium tuberculosis/patogenicidade
Técnicas de Amplificação de Ácido Nucleico/métodos
Escarro/química
Tanzânia
Tuberculose Pulmonar/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
CUB7JI0JV3 (Cetylpyridinium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2642-z


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[PMID]:28678966
[Au] Autor:Rösing CK; Cavagni J; Gaio EJ; Muniz FWMG; Ranzan N; Oballe HJR; Friedrich SA; Severo RM; Stewart B; Zhang YP
[Ad] Endereço:Universidade Federal do Rio Grande do Sul - UFRS, Faculty of Dentistry, Department of Periodontology, Porto Alegre, RS, Brazil.
[Ti] Título:Efficacy of two mouthwashes with cetylpyridinium chloride: a controlled randomized clinical trial.
[So] Source:Braz Oral Res;31:e47, 2017 Jul 03.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate the anti-plaque and anti-gingivitis effects of two mouthwashes containing cetylpyridinium chloride (CPC), in comparison to negative control mouthwash. One hundred and twenty subjects were randomly assigned to study groups: test (0.075% CPC and 0.28% zinc lactate), positive control (0.07% CPC) and negative control mouthwash without CPC. All volunteers were examined by a calibrated examiner for the Quigley-Hein Plaque Index (Turesky modification) and Löe-Silness Gingival Index (GI). Gingival severity was also measured by the percentage of sites with positive gingival bleeding. During six weeks, oral hygiene consisted of brushing twice daily with a toothbrush and toothpaste and rising with their assigned mouthwash. Plaque and gingival parameters were assessed at baseline, after four and six weeks of product use. Statistical analyses were performed separately for plaque and gingival indices, by ANOVA, paired t-test and ANCOVA (α < 0.05). After 4 and 6 weeks, all mouthwashes groups presented statistically significant reductions in plaque and gingival parameters as compared to baseline. In comparison to the positive control, the test group presented additional reductions in dental plaque of 19.8% and 16.8%, after 4 and 6 weeks, respectively. For GI, the additional reductions in the test group were 9.7% and 14.3%, at 4 and 6 weeks, respectively. The test group showed additional reduction of 35.3% and 54.5% in the gingival severity, at week 4 and 6, respectively. It is concluded that the mouthwash containing CPC and zinc lactate presents significant anti-plaque and anti-gingivitis effects as compared to positive and negative control mouthwashes.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Cetilpiridínio/uso terapêutico
Placa Dentária/prevenção & controle
Gengivite/prevenção & controle
Antissépticos Bucais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Análise de Variância
Índice de Placa Dentária
Feminino
Gengivite/patologia
Seres Humanos
Masculino
Meia-Idade
Higiene Bucal
Índice Periodontal
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
Fluoreto de Sódio/uso terapêutico
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Mouthwashes); 8ZYQ1474W7 (Sodium Fluoride); CUB7JI0JV3 (Cetylpyridinium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE


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[PMID]:28644866
[Au] Autor:Poléo ABS; Schjolden J; Sørensen J; Nilsson GE
[Ad] Endereço:Inland Norway University of Applied Sciences, Campus Evenstad, Norway.
[Ti] Título:The high tolerance to aluminium in crucian carp (Carassius carassius) is associated with its ability to avoid hypoxia.
[So] Source:PLoS One;12(6):e0179519, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is well known that aluminium is the principle toxicant killing fish in acidified freshwater systems, and it has been shown that crucian carp (Carassius carassius) can survive exposures to aqueous aluminium levels toxic to most other freshwater fish species. The crucian carp has a remarkable ability to survive anoxic conditions, and the aim of the present study was to reveal if the tolerance to aluminium can be associated with the ability to survive prolonged anoxia. Crucian carps were exposed to either acidic Al-rich water (pH 5.8; 960 µg Al/l), acidic Al-poor water (pH 5.8; 50 µg Al/l) or untreated control water (pH 6.5; 50 µg Al/l). Blood, muscle and gill samples were collected from exposed fish, and closed respirometry was performed to measure critical O2-tension an normoxic O2-consumption. The results show an increased gill surface area in Al-exposed fish, while the critical O2-tension did not change. The normoxic O2-consumption was lower in Al-exposed fish and might be due to a reduced metabolic rate. The results suggest that crucian carp exposed to aluminium do not become hypoxic, since haematocrit, plasma lactate and blood ethanol did not differ from that of control fish after 14 days of exposure. We also observed an initial loss of plasma chloride and sodium, followed by a stabilisation of these ions at a lower level than in control fish. The decrease in plasma ions caused a transient increase in haematocrit and water content in muscle tissue, returning to control levels when the ion concentrations stabilised, suggesting that the water balance was restored. We conclude that the high tolerance to aluminium in crucian carp is associated with its ability to avoid hypoxia as well as an ability to counteract a continuous loss of plasma ions.
[Mh] Termos MeSH primário: Adaptação Fisiológica/fisiologia
Alumínio/metabolismo
Alumínio/toxicidade
Carpas/metabolismo
Hipóxia/metabolismo
[Mh] Termos MeSH secundário: Animais
Carpas/anatomia & histologia
Cetilpiridínio/sangue
Condutividade Elétrica
Etanol/sangue
Água Doce/química
Brânquias/metabolismo
Brânquias/ultraestrutura
Hematócrito
Concentração de Íons de Hidrogênio
Ácido Láctico/sangue
Microscopia Eletrônica de Varredura
Músculos/metabolismo
Oxigênio/metabolismo
Consumo de Oxigênio/fisiologia
Respiração
Sódio/sangue
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
33X04XA5AT (Lactic Acid); 3K9958V90M (Ethanol); 9NEZ333N27 (Sodium); CPD4NFA903 (Aluminum); CUB7JI0JV3 (Cetylpyridinium); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179519


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[PMID]:28380086
[Au] Autor:Retamal-Valdes B; Soares GM; Stewart B; Figueiredo LC; Faveri M; Miller S; Zhang YP; Feres M
[Ad] Endereço:Universidade de Guarulhos, Department of Periodontology, Dental Research Division, Guarulhos, São Paulo, Brazil.
[Ti] Título:Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial
[So] Source:Braz Oral Res;31:e21, 2017 03 30.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this randomized, single blinded clinical trial was to evaluate the effect of a pre-procedural mouthwash containing cetylpyridinium chloride (CPC), zinc lactate (Zn) and sodium fluoride (F) in the reduction of viable bacteria in oral aerosol after a dental prophylaxis with ultrasonic scaler. Sixty systemically healthy volunteers receiving dental prophylaxis were randomly assigned to one of the following experimental groups (15 per group): (i) rinsing with 0.075% CPC, 0.28% Zn and 0.05% F (CPC+Zn+F), (ii) water or (iii) 0.12% chlorhexidine digluconate (CHX), and (iv) no rinsing. Viable bacteria were collected from different locations in the dental office on enriched TSA plates and anaerobically incubated for 72 hours. The colonies were counted and species were then identified by Checkerboard DNA-DNA Hybridization. The total number of colony-forming units (CFUs) detected in the aerosols from volunteers who rinsed with CPC+Zn+F or CHX was statistically significantly (p<0.05) lower than of those subjects who did not rinse or who rinsed with water. When all locations were considered together, the aerosols from the CPC+Zn+F and CHX groups showed, respectively, 70% and 77% fewer CFUs than those from the No Rinsing group and 61% and 70% than those from the Water group. The mean proportions of bacterial species from the orange complex were statistically significantly (p<0.05) lower in aerosols from the CPC+Zn+F and CHX groups compared with the others two groups. In conclusion, the mouthwash containing CPC+Zn+F, is effective in reducing viable bacteria in oral aerosol after a dental prophylaxis with ultrasonic scaler.
[Mh] Termos MeSH primário: Aerossóis
Anti-Infecciosos Locais/uso terapêutico
Bactérias/efeitos dos fármacos
Boca/microbiologia
Antissépticos Bucais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Cetilpiridínio/uso terapêutico
Contagem de Colônia Microbiana
Sondas de DNA
DNA Bacteriano
Feminino
Seres Humanos
Lactatos/uso terapêutico
Masculino
Meia-Idade
Antissépticos Bucais/química
Reprodutibilidade dos Testes
Método Simples-Cego
Fluoreto de Sódio/uso terapêutico
Estatísticas não Paramétricas
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
Zinco/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Aerosols); 0 (Anti-Infective Agents, Local); 0 (DNA Probes); 0 (DNA, Bacterial); 0 (Lactates); 0 (Mouthwashes); 8ZYQ1474W7 (Sodium Fluoride); CUB7JI0JV3 (Cetylpyridinium); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


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ALVES, Sydney Hartz
Texto completo SciELO Brasil
[PMID]:28327805
[Au] Autor:Reginato CF; Bandeira LA; Zanette RA; Santurio JM; Alves SH; Danesi CC
[Ad] Endereço:Programa de Pós-Graduação em Ciências Odontológicas, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
[Ti] Título:Antifungal activity of synthetic antiseptics and natural compounds against Candida dubliniensis before and after in vitro fluconazole exposure.
[So] Source:Rev Soc Bras Med Trop;50(1):75-79, 2017 Jan-Feb.
[Is] ISSN:1678-9849
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION:: This study evaluated the susceptibilities of oral candidiasis-derived Candida albicans, fluconazole-resistant (FR) Candida dubliniensis, and fluconazole-susceptible (FS) C. dubliniensis to synthetic antiseptics [chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), and triclosan (TRC)] and natural compounds (carvacrol, eugenol and thymol). METHODS:: Susceptibility tests were performed based on the M27-A3 reference method. The fluconazole-resistant C. dubliniensis strains were obtained after prolonged in vitro exposure to increasing fluconazole concentrations. The geometric mean values for minimum inhibitory concentrations and minimum fungicidal concentrations were compared among the groups. RESULTS: : Fluconazole-susceptible C. dubliniensis was more sensitive to CPC and TRC than FR C. dubliniensis and C. albicans were. However, eugenol and thymol were more active against FR C. dubliniensis. The fungicidal activities of CHX and TRC were similar for the three groups, and FR C. dubliniensis and C. albicans had similar sensitivities to CPC. CONCLUSIONS:: The resistance of C. dubliniensis to fluconazole affects its sensitivity the synthetic antiseptics and natural compounds that were tested.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/farmacologia
Antifúngicos/farmacologia
Candida/efeitos dos fármacos
Fluconazol/farmacologia
[Mh] Termos MeSH secundário: Candida/classificação
Candida/isolamento & purificação
Candida albicans/efeitos dos fármacos
Cetilpiridínio/farmacologia
Clorexidina/farmacologia
Eugenol/farmacologia
Seres Humanos
Testes de Sensibilidade Microbiana
Timol/farmacologia
Triclosan/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Antifungal Agents); 3J50XA376E (Thymol); 3T8H1794QW (Eugenol); 4NM5039Y5X (Triclosan); 8VZV102JFY (Fluconazole); CUB7JI0JV3 (Cetylpyridinium); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28285196
[Au] Autor:Deese RD; Weldeghiorghis TK; Haywood BJ; Cook RL
[Ad] Endereço:Choppin Hall, Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA.
[Ti] Título:Influence of surfactants and humic acids on Artemia Franciscana's embryonic phospho-metabolite profile as measured by P NMR.
[So] Source:Aquat Toxicol;186:188-195, 2017 May.
[Is] ISSN:1879-1514
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Surfactants, such as triton X-100 (Tx-100), cetylpyridinium chloride (CPC), and sodium dodecyl sulfate (SDS) are known to be toxic to Artemia Franciscana (Artemia) - an organism, frequently used to monitor the health of the aquatic environment. The phospho-metabolite profile of a living organism is often indicative of imbalances that may have been caused by environmental stressors, such as surfactants. This study utilizes in vivo P NMR to monitor temporal changes in the phospho-metabolite profile of Artemia caused by Tx-100, CPC, and SDS and the ability of humic acid (HA) to mitigate the toxicity of these surfactants. It was found that, while Tx-100 does not have any effect on the phospho-metabolite profile, both CPC and SDS cause a complete retardation in growth of the phosphodiester (PDE) peak in the P NMR spectrum, which is indicative of the inhibited cell replication. This growth inhibition was independently verified by the decreased guanosine triphosphate (GTP) concentration in the CPC and SDS-exposed Artemia. In addition, upon introduction of HA to the CPC and SDS-exposed Artemia, an increase of PDE peak over time is indicative of HA mitigating toxicity.
[Mh] Termos MeSH primário: Artemia/efeitos dos fármacos
Artemia/embriologia
Embrião não Mamífero/metabolismo
Substâncias Húmicas/análise
Espectroscopia de Ressonância Magnética/métodos
Metabolômica
Fósforo/metabolismo
Tensoativos/toxicidade
[Mh] Termos MeSH secundário: Animais
Cetilpiridínio/toxicidade
Cromatografia Líquida de Alta Pressão
Embrião não Mamífero/efeitos dos fármacos
Minerais/toxicidade
Octoxinol/toxicidade
Cloreto de Sódio/farmacologia
Dodecilsulfato de Sódio/toxicidade
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Humic Substances); 0 (Minerals); 0 (Surface-Active Agents); 0 (Water Pollutants, Chemical); 0 (leonardite); 27YLU75U4W (Phosphorus); 368GB5141J (Sodium Dodecyl Sulfate); 451W47IQ8X (Sodium Chloride); 9002-93-1 (Octoxynol); CUB7JI0JV3 (Cetylpyridinium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


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[PMID]:28178381
[Au] Autor:Youn SY; Jeong OM; Choi BK; Jung SC; Kang MS
[Ad] Endereço:Animal and Plant Quarantine Agency, Gimcheon-si, Gyeongsangbuk-do, 39660, Korea.
[Ti] Título:Comparison of the Antimicrobial and Sanitizer Resistance of Salmonella Isolates from Chicken Slaughter Processes in Korea.
[So] Source:J Food Sci;82(3):711-717, 2017 Mar.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Salmonella is a foodborne pathogen worldwide. Outbreaks of Salmonella are commonly associated with consumption of contaminated foods such as poultry products. Therefore, the objective of this study was to determine the occurrence, biofilm formation, antibiotic resistance, and sanitizer resistance of Salmonella enterica isolated from chicken carcasses. A total of 318 samples were collected from 15 chicken slaughterhouses in 8 provinces of Korea. They were then examined for Salmonella contamination. S. enterica isolates were tested for their susceptibilities to 15 antimicrobials by broth microdilution method. Their biofilm formation ability and resistance to sanitizers were also evaluated. Eighty-two isolates of S. enterica were obtained from the 318 samples. There were 14 serotypes and 2 untypable isolates. Fifty-seven (69.5%) isolates were resistant to at least one antibiotic while 30 (36.6%) isolates were resistant to 5 or more antibiotics. Two S. Senftenberg and 3 S. Montevideo isolates exhibited considerable biofilm formation ability (A >0.2) following incubation in Luria-Bertani (LB) broth for 48 h. Biofilm cell survival and recovery growth assay after sanitization showed that most isolates were highly susceptible to 2.5% lactic acid and 0.1% cetylpyridinium chloride. Therefore, lactic acid and cetylpyridinium chloride might be alternatively or additionally used in addition to chlorine-based sanitizers that are frequently used to reduce Salmonella contamination of chicken carcasses. Our results provide basic information on the distribution of Salmonella serotypes in chicken slaughterhouses. This study also highlights the necessity to improve farming practices and use antimicrobial agents cautiously. This study also suggests that sanitization during the slaughtering process might be necessary to reduce Salmonella contamination of chicken carcasses.
[Mh] Termos MeSH primário: Matadouros
Antibacterianos/farmacologia
Anti-Infecciosos/farmacologia
Biofilmes/efeitos dos fármacos
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Produtos Avícolas/microbiologia
Salmonella enterica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cetilpiridínio/farmacologia
Galinhas/microbiologia
Cloro/farmacologia
Microbiologia de Alimentos
Doenças Transmitidas por Alimentos/microbiologia
Seres Humanos
Ácido Láctico/farmacologia
Testes de Sensibilidade Microbiana
República da Coreia
Salmonella enterica/isolamento & purificação
Sorogrupo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 33X04XA5AT (Lactic Acid); 4R7X1O2820 (Chlorine); CUB7JI0JV3 (Cetylpyridinium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13630


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[PMID]:28088167
[Au] Autor:Mukherjee PK; Esper F; Buchheit K; Arters K; Adkins I; Ghannoum MA; Salata RA
[Ad] Endereço:Center for Medical Mycology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA.
[Ti] Título:Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections.
[So] Source:BMC Infect Dis;17(1):74, 2017 Jan 14.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Current prevention options for upper respiratory infections (URIs) are not optimal. We conducted a randomized, double-blinded, placebo-controlled pilot clinical trial to evaluate the safety and efficacy of ARMS-I™ (currently marketed as Halo™) in the prevention of URIs. METHODS: ARMS-I is patented novel formulation for the prevention and treatment of influenza, comprising a broad-spectrum antimicrobial agent (cetylpyridinium chloride, CPC) and components (glycerin and xanthan gum) that form a barrier on the host mucosa, thus preventing viral contact and invasion. Healthy adults (18-45 years of age) were randomized into ARMS-I or placebo group (50 subjects each). The drug was sprayed intra-orally (3× daily) for 75 days. The primary objectives were to establish whether ARMS-I decreased the frequency, severity or duration of URIs. Secondary objectives were to evaluate safety, tolerability, rate of virus detection, acceptability and adherence; effect on URI-associated absenteeism and medical visits; and effect of prior influenza vaccination on study outcomes. RESULTS: Of the 94 individuals who completed the study (placebo: n = 44, ARMS-I: n = 50), six presented with confirmed URI (placebo: 4, ARMS-I: 2), representing a 55% relative reduction, albeit this was statistically not significant). Influenza, coronavirus or rhinovirus were detected in three participants; all in the placebo group. Moreover, frequency of post-treatment exit visits was reduced by 55% in ARMS-I compared to the placebo group (N = 4 and 2, respectively). Fever was reported only in the placebo group. ARMS-I significantly reduced the frequency and severity of cough and sore throat, and duration of cough (P ≤ .019 for all comparisons). ARMS-I was safe, well tolerated, had high acceptability and high adherence to medication use. Medical visits occurred only in the placebo group while absenteeism did not differ between the two arms. Prior influenza vaccination had no effect on study outcome. CONCLUSIONS: This randomized proof-of-concept clinical trial demonstrated that ARMS-I tended to provide protection against URIs in the enrolled study participants, while reducing severity and duration of cough and sore throat. A clinical trial with a larger number of study participants is warranted. TRIAL REGISTRATION: ClinicalTrials.gov NCT02644135 (retrospectively registered).
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Cetilpiridínio/uso terapêutico
Resfriado Comum/prevenção & controle
Infecções por Coronavirus/prevenção & controle
Influenza Humana/prevenção & controle
Infecções Respiratórias/prevenção & controle
[Mh] Termos MeSH secundário: Administração Oral
Administração Tópica
Adolescente
Adulto
Resfriado Comum/complicações
Coronavirus/isolamento & purificação
Infecções por Coronavirus/complicações
Tosse/etiologia
Tosse/prevenção & controle
Método Duplo-Cego
Feminino
Glicerol/uso terapêutico
Seres Humanos
Vacinas contra Influenza/uso terapêutico
Influenza Humana/complicações
Masculino
Meia-Idade
Sprays Orais
Orthomyxoviridae/isolamento & purificação
Faringite/etiologia
Faringite/prevenção & controle
Projetos Piloto
Polissacarídeos Bacterianos/uso terapêutico
Infecções Respiratórias/complicações
Rhinovirus/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Influenza Vaccines); 0 (Oral Sprays); 0 (Polysaccharides, Bacterial); CUB7JI0JV3 (Cetylpyridinium); PDC6A3C0OX (Glycerol); TTV12P4NEE (xanthan gum)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170116
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-016-2177-8


  10 / 859 MEDLINE  
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[PMID]:28040664
[Au] Autor:Markovic M; Dakovic A; Rottinghaus GE; Kragovic M; Petkovic A; Krajisnik D; Milic J; Mercurio M; de Gennaro B
[Ad] Endereço:Institute for Technology of Nuclear and Other Mineral Raw Materials, Franse d' Epere 86, 11000 Belgrade, Serbia. Electronic address: m.markovic@itnms.ac.rs.
[Ti] Título:Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant.
[So] Source:Colloids Surf B Biointerfaces;151:324-332, 2017 Mar 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, organozeolites were prepared by treatment of the natural zeolites (clinoptilolite and phillipsite) with cetylpyridinium chloride (CP) equivalent to 50 and 100% of their external cation exchange capacities (ECEC). Organoclinoptilolites (ZCPs) and organophillipsites (PCPs) were characterized by FTIR spectroscopy, thermal analysis, determination of the point of zero charge and zeta potential. Adsorption of zearalenone (ZEN) by ZCPs and PCPs at pH 3 and 7 was investigated. Results showed that adsorption of ZEN increases with increasing amounts of CP at the zeolitic surfaces for both ZCPs and PCPs but the adsorption mechanism was different. Adsorption of ZEN by ZCPs followed a linear type of isotherm at pH 3 and 7 while ZEN adsorption by PCPs showed non linear (Langmuir and Freundlich) type of isotherm at both pH values. Different interactions between the ZEN molecule (or ion) and ZCPs and PCPs occurred: partition (linear isotherms) and adsorption in addition to partition (non linear isotherms), respectively. For the highest level of organic phase at the zeolitic surfaces, the maximum adsorbed amount of ZEN was 5.73mg/g for organoclinoptilolite and 6.86mg/g for organophillipsite at pH 3. Slightly higher adsorption: 6.98mg/g for organoclinoptilolite and 7.54mg/g for organophillipsite was achieved at pH 7. The results confirmed that CP ions at both zeolitic surfaces are responsible for ZEN adsorption and that organophillipsites are as effective in ZEN adsorption as organoclinoptilolites.
[Mh] Termos MeSH primário: Cetilpiridínio/química
Micotoxinas/química
Zearalenona/química
Zeolitas/química
[Mh] Termos MeSH secundário: Adsorção
Animais
Temperatura Alta
Seres Humanos
Concentração de Íons de Hidrogênio
Íons
Modelos Lineares
Espectroscopia de Infravermelho com Transformada de Fourier
Propriedades de Superfície
Tensoativos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ions); 0 (Mycotoxins); 0 (Surface-Active Agents); 12174-18-4 (phillipsite); 1318-02-1 (Zeolites); 5W827M159J (Zearalenone); CUB7JI0JV3 (Cetylpyridinium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE



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