Base de dados : MEDLINE
Pesquisa : D03.383.725.791.496.371 [Categoria DeCS]
Referências encontradas : 168 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 17 ir para página                         

  1 / 168 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26819427
[Au] Autor:Wang N; Xu Q; Duan S; Lei R; Guo J
[Ad] Endereço:Department of Nephrology, Second People's Hospital, Hefei 230000, China.
[Ti] Título:[Evaluation of risk factors and prognosis on diodone-induced acute kidney injury according to ESUR and KDIGO criteria].
[So] Source:Zhong Nan Da Xue Xue Bao Yi Xue Ban;41(1):65-70, 2016 Jan.
[Is] ISSN:1672-7347
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the incidence, risk factors and prognosis for contrast-induced acute kidney injury (CI-AKI) according to ESUR and KDIGO criteria in patients undergoing angiography.
 METHODS: We evaluated 260 patients undergoing angiography and/or intervention therapy from April 2011 to January 2012 in the Second Xiangya Hospital of Central South University. All patients received low-osmolality contrast agent (ioversol). Serum creatinine was measured before angiography or at 48 or 72 h after procedure. The multivariate logistic regression was used to analyze the risk factors of CI-AKI. The major adverse events were observed in a year of follow-up.
 RESULTS: Among the 260 patients, 23 experienced CI-AKI and the incidence was 8.8% according to ESUR criteria. Twelve patients experienced CI-AKI and the incidence was 4.6% according to KDIGO criteria. The multivariate logistic regression analysis showed that diabetes mellitus and dehydration were the independent risk factors for CI-AKI according to ESUR criteria; In another KDIGO criteria, chronic kidney disease (CKD), hypercholesterolemia and diabetes mellitus were the independent risk factors for CI-AKI. The prognosis study showed that the mortality of patients with CI-AKI were significantly higher than those without CI-AKI (P<0.05).
 CONCLUSION: The incidence of CI-AKI is associated with diagnostic criteria. Diabetes mellitus, CKD, dehydration and hypercholesterolemia were the independent risk factors for CI-AKI. CI-AKI is a relevant factor for mortality in a year after angiography and/or intervention therapy.
[Mh] Termos MeSH primário: Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/diagnóstico
Meios de Contraste/efeitos adversos
Iodoperaceto/efeitos adversos
[Mh] Termos MeSH secundário: Lesão Renal Aguda/mortalidade
Angiografia
Desidratação/epidemiologia
Diabetes Mellitus/epidemiologia
Seres Humanos
Incidência
Modelos Logísticos
Prognóstico
Insuficiência Renal Crônica/epidemiologia
Fatores de Risco
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contrast Media); ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160128
[Lr] Data última revisão:
160128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160129
[St] Status:MEDLINE
[do] DOI:10.11817/j.issn.1672-7347.2016.01.010


  2 / 168 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:20070119
[Au] Autor:Ren X; Kondakova ME; Giesen DJ; Rajeswaran M; Madaras M; Lenhart WC
[Ad] Endereço:Research Laboratories, Eastman Kodak Company, 1999 Lake Avenue, Rochester, New York 14650-2103, USA. xiaofan.ren@kodak.com
[Ti] Título:Coumarin-based, electron-trapping iridium complexes as highly efficient and stable phosphorescent emitters for organic light-emitting diodes.
[So] Source:Inorg Chem;49(4):1301-3, 2010 Feb 15.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new class of coumarin-based iridium tris-cyclometalated complexes has been developed. These complexes are highly emissive, with emission colors ranging from green to orange-red. Besides modification of ligand structures, color tuning was realized by incorporation of ligands with different electrochemical properties in a heteroleptic structure. The organic light-emitting diodes (OLEDs) using these compounds as emissive dopants are highly efficient and stable. Unlike other Ir(III) phosphorescent dopants, these coumarin-based Ir(III) dopants can effectively trap and transport electrons in the emissive layer.
[Mh] Termos MeSH primário: Cumarínicos/química
Elétrons
Iodoperaceto/química
Irídio/química
Luz
[Mh] Termos MeSH secundário: Medições Luminescentes/métodos
Estrutura Molecular
Fotoquímica/métodos
Espectrometria de Fluorescência
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 44448S9773 (Iridium); A4VZ22K1WT (coumarin); ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:1004
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100115
[St] Status:MEDLINE
[do] DOI:10.1021/ic9022097


  3 / 168 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:14734677
[Au] Autor:Shikano N; Kanai Y; Kawai K; Ishikawa N; Endou H
[Ad] Endereço:Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan. sikano@ipu.ac.jp
[Ti] Título:Transport of 99mTc-MAG3 via rat renal organic anion transporter 1.
[So] Source:J Nucl Med;45(1):80-5, 2004 Jan.
[Is] ISSN:0161-5505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Recently, complementary DNA (cDNA) encoding a p-aminohippurate (PAH) transporter designated rat organic anion transporter 1 (OAT1) was isolated. OAT1, a multispecific organic anion transporter at the basolateral membrane, is exclusively expressed in the middle segment of the proximal tubule in the rat kidney. It has been proposed that OAT1 is indirectly involved in PAH uptake via the Na(+) dicarboxylate cotransporter. In this study, in molecular biologic experiments using OAT1-expressing Xenopus laevis oocytes, we obtained evidence that (99m)Tc-mercaptoacetylglycylglycylglycine (MAG3) is transported via OAT1. METHODS: Capped OAT1 complementary RNA (cRNA) was synthesized from library plasmid cDNA linearized with BamHI using in vitro transcription. Defolliculated oocytes were injected with 10 ng of OAT1 cRNA. Two to 3 d after injection, uptake of (99m)Tc-MAG3 was measured using ND96 solution containing 18.5 kBq of (99m)Tc-MAG3. Before the uptake experiments, OAT1-expressing oocytes were preincubated for 2 h with 1 mmol/L glutarate (a dicarboxylate), to generate an outwardly directed glutarate gradient. Then, after incubation for 60 min at room temperature, radioactivity of oocytes was determined. For the inhibition experiments, uptake was assessed in the absence or presence of inhibitor: 2 mmol/L of PAH, o-iodohippurate (OIH), probenecid, 3,5-diiodo-4-pyridone-N-acetate (iodopyracet), furosemide, ethacrynic acid, glucoheptonate, maleic acid, L-Tyr, or tetraethylammonium (TEA) or 0.1 mmol/L of 2,4-dinitrophenol (DNP). RESULTS: Na(+) had a significant effect on (99m)Tc-MAG3 uptake (P < 0.05). Accumulated glutarate stimulated simultaneous (99m)Tc-MAG3 uptake and glutarate excretion (P < 0.001). The following compounds significantly inhibited (99m)Tc-MAG3 uptake: PAH, 8.5% +/- 16.2% of (99m)Tc-MAG3 uptake in the absence of an inhibitor; OIH, 26.4% +/- 21.7%; probenecid, 29.1% +/- 12.4%; iodopyracet, 15.8% +/- 7.9%; furosemide, 30.5% +/- 15.7%; ethacrynic acid, 21.6% +/- 10.6%; glucoheptonate, 35.6% +/- 22.6%; and maleic acid, 60.1% +/- 18.7%. (99m)Tc-MAG3 accumulation in Xenopus laevis oocytes was not significantly inhibited by TEA, L-Tyr, or DNP. CONCLUSION: The following substances had a cis-inhibitory effect on (99m)Tc-MAG3 transport: PAH, OIH, probenecid, iodopyracet, furosemide, ethacrynic acid, and glucoheptonate. Glutarate had a trans-stimulative effect on (99m)Tc-MAG3 transport. (99m)Tc-MAG3 acts as a substrate of OAT1, an organic anion/dicarboxylate exchanger.
[Mh] Termos MeSH primário: Oócitos/metabolismo
Canais de Potássio/metabolismo
Sódio/metabolismo
Tecnécio Tc 99m Mertiatida/farmacocinética
[Mh] Termos MeSH secundário: Animais
Transporte Biológico Ativo/efeitos dos fármacos
Transporte Biológico Ativo/fisiologia
Células Cultivadas
Furosemida/farmacologia
Iodoperaceto/farmacologia
Taxa de Depuração Metabólica
Oócitos/diagnóstico por imagem
Oócitos/efeitos dos fármacos
Canais de Potássio/efeitos dos fármacos
Probenecid/farmacologia
Técnica de Diluição de Radioisótopos
Cintilografia
Ratos
Proteínas Recombinantes/metabolismo
Sódio/farmacologia
Xenopus laevis
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Potassium Channels); 0 (Recombinant Proteins); 36ITO9SKQJ (Technetium Tc 99m Mertiatide); 7LXU5N7ZO5 (Furosemide); 9NEZ333N27 (Sodium); PO572Z7917 (Probenecid); ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:0404
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040122
[St] Status:MEDLINE


  4 / 168 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:10382358
[Au] Autor:Beliaev LB; Pikuza VI; Iudin EV; Sukhanov AI; Kotsiuba AK; Starodubov VS
[Ti] Título:[The characteristics of surgical cholangiography].
[Ti] Título:Osobennosti operatsionnoi kholangiografii..
[So] Source:Voen Med Zh;320(4):40-3, 1999 Apr.
[Is] ISSN:0026-9050
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos do Sistema Biliar/métodos
Colangiografia/métodos
Radiografia Intervencionista/métodos
[Mh] Termos MeSH secundário: Adulto
Colangiopancreatografia Retrógrada Endoscópica
Colecistectomia Laparoscópica
Meios de Contraste
Diatrizoato
Diatrizoato de Meglumina
Feminino
Seres Humanos
Iodoperaceto
Masculino
Mesilatos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Mesylates); 117-96-4 (Diatrizoate); 3X9MR4N98U (Diatrizoate Meglumine); 5UVC90J1LK (diatrizoic acid); ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:9907
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:990626
[St] Status:MEDLINE


  5 / 168 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:7756965
[Au] Autor:Ul'ianov GP
[Ti] Título:[The effect of cimetidine on the renal excretion of verografin and iodamide in dogs].
[Ti] Título:Vliianie tsimetidina na pochechnuiu ékskretsiiu verografina i iodamida u sobak..
[So] Source:Eksp Klin Farmakol;57(6):53-4, 1994 Nov-Dec.
[Is] ISSN:0869-2092
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The intravenous injection of cimetidine in a dose of 20 mg/kg enhanced verografine and iodamide excretion in chronic canine experiments. The higher verografine and iodamide excretion was due to their increased renal tubular secretion. In dogs, cimetidine unchanged the secretion of cardiotrast, a test agent for anionic transport. Possible extrarenal mechanisms of action of cimetidine on verografine and iodamide transport were also examined.
[Mh] Termos MeSH primário: Cimetidina/farmacologia
Diatrizoato de Meglumina/metabolismo
Iodamida/metabolismo
Rim/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cimetidina/administração & dosagem
Diatrizoato de Meglumina/análise
Diurese/efeitos dos fármacos
Cães
Interações Medicamentosas
Taxa de Filtração Glomerular/efeitos dos fármacos
Iodamida/análise
Iodoperaceto/análise
Iodoperaceto/metabolismo
Rim/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
3X9MR4N98U (Diatrizoate Meglumine); 4RII332O0R (Iodamide); 80061L1WGD (Cimetidine); ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:9506
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:941101
[St] Status:MEDLINE


  6 / 168 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:2384854
[Au] Autor:Katayama K; Ohtani H; Kawabe T; Mizuno H; Endoh M; Kakemi M; Koizumi T
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
[Ti] Título:Kinetic studies on drug disposition in rabbits. I. Renal excretion of iodopyracet and sulfamethizole.
[So] Source:J Pharmacobiodyn;13(2):97-107, 1990 Feb.
[Is] ISSN:0386-846X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:In order to quantify the renal handling of iodopyracet (IOD) and sulfamethizole (SMZ), single-drug clearance studies in rabbits were performed under quasi-steady state conditions with stepwise increasing the infusion rate of IOD or SMZ. Although concentration dependence of plasma protein binding was observed for both drugs, the urinary excretion rate of IOD was proportional to its total plasma concentration at low total plasma concentrations of 0.05-0.8 mM. On the other hand, the relationship between urinary excretion rate and total plasma concentration of SMZ was a concave-ascending curve at low plasma concentrations and the renal clearance of SMZ was sensitive to changes in plasma protein binding. However, renal clearances referenced to unbound plasma concentration at total plasma concentrations of 0.05 mM for IOD and SMZ were 9.5 and 38 l/h, respectively. Those values were much greater than the effective plasma flow in rabbits. These facts indicated that the intrinsic clearances at the sites of tubular secretion were high and that the rates of secretion were fully or partially limited by the renal plasma flow. Furthermore it was suggested that unbound drug was liberated from plasma protein at the sites of tubular secretion. The data obtained at high plasma concentrations indicated that the tubular secretion of IOD had capacity limited characteristics and that the urinary excretion of SMZ involved tubular reabsorption as well as saturable tubular secretion. From the data obtained, a perfusion-limited pharmacokinetic model was constructed characterizing the excretory processes, namely, glomerular filtration, passive tubular reabsorption, saturable tubular secretion and reequilibrium between bound and unbound drugs in plasma. For both drugs, the estimates for bulk flow rate were reasonable values of effective renal plasma flow and the dissociation constants for tubular secretion agreed well with those for in vitro renal cortex accumulation, suggesting that the kinetic model based on physiological concepts was useful for the understanding of the drug elimination processes.
[Mh] Termos MeSH primário: Iodoperaceto/farmacocinética
Rim/metabolismo
Coelhos/metabolismo
Sulfametizol/farmacocinética
Sulfatiazóis/farmacocinética
[Mh] Termos MeSH secundário: Animais
Proteínas Sanguíneas/metabolismo
Córtex Renal/anatomia & histologia
Glomérulos Renais/fisiologia
Túbulos Renais/secreção
Modelos Biológicos
Perfusão
Ligação Proteica
Sulfametizol/sangue
Sulfametizol/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Sulfathiazoles); 25W8454H16 (Sulfamethizole); ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:9009
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900201
[St] Status:MEDLINE


  7 / 168 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:2374087
[Au] Autor:Katayama K; Tsubota E; Endoh M; Kakemi M; Koizumi T
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
[Ti] Título:Effect of iodopyracet on renal excretion of sulfamethizole in rabbits.
[So] Source:J Pharmacobiodyn;13(3):179-85, 1990 Mar.
[Is] ISSN:0386-846X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:To predict quantitatively drug interaction kinetics from the single-drug clearance studies, we examined the effect of iodopyracet (IOD) on sulfamethizole (SMZ) excretion in rabbits. Even though the decline of systemic IOD plasma concentration was linear, the renal clearance of SMZ decreased significantly in the presence of IOD. The results could be described by a perfusion model incorporated with the competitive inhibition for tubular secretion. For IOD with a high extraction ratio, it was suggested that a heavy load of the drug was supplied to the sites of secretion and caused the saturation of transport systems, even though the renal excretion kinetics were apparently linear in respect to the systemic circulation. These facts indicated that a linear relationship between the concentrations in the systemic circulation and at the sites of tubular secretion can not always be presumed. Consequently, SMZ-IOD interaction study stressed the importance of the drug concentrations at the sites of interaction for quantitative elucidation of drug-drug interactions.
[Mh] Termos MeSH primário: Iodoperaceto/farmacologia
Córtex Renal/metabolismo
Sulfametizol/farmacocinética
Sulfatiazóis/farmacocinética
[Mh] Termos MeSH secundário: Animais
Interações Medicamentosas
Técnicas In Vitro
Córtex Renal/efeitos dos fármacos
Masculino
Taxa de Depuração Metabólica/efeitos dos fármacos
Modelos Biológicos
Coelhos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfathiazoles); 25W8454H16 (Sulfamethizole); ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:9008
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900301
[St] Status:MEDLINE


  8 / 168 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:2328806
[Au] Autor:Ul'ianov GP; Lampatov VV
[Ti] Título:[The renal transport of cardiotrast, verografin and iodamide].
[Ti] Título:Pochechnyi transport kardiotrasta, verografina i iodamida..
[So] Source:Farmakol Toksikol;53(1):62-4, 1990 Jan-Feb.
[Is] ISSN:0014-8318
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In chronic experiments on dogs it was shown that verografin and iodamide are excreted from the body not only by filtration but by tubular excretion as well. The maximal transport of verografin and iodamide is significantly lower than that of cardiotrast. In experiments on rats similar results were obtained. Concurrent administration of verografin and iodamide with cardiotrast decreases their excretion in the urine in rats that is probably due to competition for the common transport system in the epithelium of renal tubules.
[Mh] Termos MeSH primário: Diatrizoato de Meglumina/farmacocinética
Iodamida/farmacocinética
Iodobenzoatos/farmacocinética
Iodoperaceto/farmacocinética
Rim/metabolismo
[Mh] Termos MeSH secundário: Animais
Transporte Biológico/efeitos dos fármacos
Diatrizoato de Meglumina/análise
Cães
Interações Medicamentosas
Inulina/farmacocinética
Iodamida/análise
Iodoperaceto/análise
Rim/efeitos dos fármacos
Ratos
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodobenzoates); 3X9MR4N98U (Diatrizoate Meglumine); 4RII332O0R (Iodamide); 9005-80-5 (Inulin); ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:9005
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900101
[St] Status:MEDLINE


  9 / 168 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:2713458
[Au] Autor:Arion VIa; Berkhin EB; Galiuteva GI; Ul'ianov GP; Sanina IV
[Ti] Título:[Effect of taktivin on diuresis and tubular cardiotrast secretion in the kidney].
[Ti] Título:Vliianie taktivina na mocheotdelenie i kanal'tsevuiu sekretsiiu kardiotrasta v pochke..
[So] Source:Biull Eksp Biol Med;107(3):264-6, 1989 Mar.
[Is] ISSN:0365-9615
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The effect of a new immunomodulator taktivin (7-20 micrograms/kg subcutaneously, for 6 days) on the diuresis and tubular transport of cardiotrast (diodrast) was studied on rats. taktivin was shown to increase the tubular transport of the xenobiotic without significant changes in glomerular filtration and renal excretion of water, sodium, potassium, uric acid and creatinine. Possible mechanism of taktivin's action on the tubular transport of xenobiotics is discussed.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/farmacologia
Diurese/efeitos dos fármacos
Iodoperaceto/farmacocinética
Túbulos Renais/efeitos dos fármacos
Peptídeos/farmacologia
Extratos do Timo/farmacologia
[Mh] Termos MeSH secundário: Animais
Transporte Biológico/efeitos dos fármacos
Taxa de Filtração Glomerular/efeitos dos fármacos
Túbulos Renais/fisiologia
Ratos
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Peptides); 0 (Thymus Extracts); 89492-35-3 (T-activin); ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:8906
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:890301
[St] Status:MEDLINE


  10 / 168 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:2707421
[Au] Autor:Berkhin EB; Gossen IE
[Ti] Título:[Tubular secretion of cardiotrast in the progeny of rats receiving it throughout pregnancy].
[Ti] Título:Kan al'tsevaia sekretsiia kardiotrasta u potomstva krys, poluchavshikh ego na protiazhenii beremennosti..
[So] Source:Farmakol Toksikol;52(1):48-50, 1989 Jan-Feb.
[Is] ISSN:0014-8318
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Administration of cardiotrast (50-80 mg twice a day subcutaneously) during pregnancy was shown to induce a significant suppression of tubular secretion of the xenobiotic in the offspring. When cardiotrast was given only in the postnatal period, tolerance failed to develop.
[Mh] Termos MeSH primário: Iodoperaceto/secreção
Túbulos Renais/secreção
Prenhez/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Depressão Química
Diurese/efeitos dos fármacos
Feminino
Iodoperaceto/farmacologia
Túbulos Renais/efeitos dos fármacos
Gravidez
Ratos
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
ZTK4026YJ5 (Iodopyracet)
[Em] Mês de entrada:8906
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:890101
[St] Status:MEDLINE



página 1 de 17 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde