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  1 / 290 MEDLINE  
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[PMID]:28259984
[Au] Autor:Kuroyanagi G; Tokuda H; Yamamoto N; Kainuma S; Fujita K; Ohguchi R; Matsushima-Nishiwaki R; Kozawa O; Otsuka T
[Ad] Endereço:Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467­8601, Japan.
[Ti] Título:Attenuation of prostaglandin E1­induced osteoprotegerin synthesis in osteoblasts by normoxic HIF inducers.
[So] Source:Mol Med Rep;15(4):1847-1852, 2017 Apr.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Mimosine, which is a natural plant amino acid present in the Leucaena genus, is able to induce hypoxia­inducible factors (HIFs). Previous evidence has indicated that HIF regulates angiogenesis­osteogenesis coupling in bone metabolism, and it has previously been reported that mimosine inhibits prostaglandin (PG)F2α­induced osteoprotegerin (OPG) synthesis without affecting interleukin­6 (IL­6) production in osteoblast­like MC3T3­E1 cells. In addition, PGE1 has been demonstrated to induce OPG synthesis via activation of p38 mitogen­activated protein (MAP) kinase and stress­activated protein kinase/c­Jun N­terminal kinase (SAPK/JNK) in these cells, and PGE1 stimulates IL­6 production via the activation of protein kinase A. In the present study, the effects of mimosine on the PGE1­stimulated synthesis of OPG and IL­6 were investigated in osteoblast­like MC3T3­E1 cells. The concentrations of OPG and IL­6 were measured using relevant ELISA kits. OPG mRNA was measured by semi­quantitative reverse transcription polymerase chain reaction. The phosphorylation of p38 MAP kinase and SAPK/JNK was analyzed by western blotting. Mimosine significantly reduced PGE1­induced release of OPG and OPG mRNA expression levels without affecting the release of IL­6. In addition, deferoxamine, which is also a normoxic HIF inducer, significantly inhibited PGE1­induced OPG release and OPG mRNA expression levels; however, it had little effect on IL­6 release. Furthermore, mimosine and deferoxamine failed to affect PGE1­stimulated phosphorylation of p38 MAP kinase or SAPK/JNK. These results strongly suggest that normoxic HIF inducers attenuate PGE1­stimulated OPG synthesis without affecting IL­6 production in osteoblasts.
[Mh] Termos MeSH primário: Alprostadil/metabolismo
Desferroxamina/farmacologia
Fator 1 Induzível por Hipóxia/agonistas
Mimosina/farmacologia
Osteoblastos/efeitos dos fármacos
Osteoprotegerina/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Fabaceae/química
Fator 1 Induzível por Hipóxia/metabolismo
Interleucina-6/metabolismo
MAP Quinase Quinase 4/metabolismo
Camundongos
Mimosina/química
Osteoblastos/citologia
Osteoblastos/metabolismo
Osteoprotegerina/genética
Fosforilação/efeitos dos fármacos
Biossíntese de Proteínas
RNA Mensageiro/genética
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoxia-Inducible Factor 1); 0 (Interleukin-6); 0 (Osteoprotegerin); 0 (RNA, Messenger); 500-44-7 (Mimosine); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 2.7.12.2 (MAP Kinase Kinase 4); F5TD010360 (Alprostadil); J06Y7MXW4D (Deferoxamine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2017.6177


  2 / 290 MEDLINE  
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[PMID]:27213712
[Au] Autor:Nguyen BC; Tawata S
[Ad] Endereço:Department of Bioscience and Biotechnology, The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima, 890-0065, Japan.
[Ti] Título:The Chemistry and Biological Activities of Mimosine: A Review.
[So] Source:Phytother Res;30(8):1230-42, 2016 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mimosine [ß-[N-(3-hydroxy-4-oxypyridyl)]-α-aminopropionic acid] is a non-protein amino acid found in the members of Mimosoideae family. There are a considerable number of reports available on the chemistry, methods for estimation, biosynthesis, regulation, and degradation of this secondary metabolite. On the other hand, over the past years of active research, mimosine has been found to have various biological activities such as anti-cancer, antiinflammation, anti-fibrosis, anti-influenza, anti-virus, herbicidal and insecticidal activities, and others. Mimosine is a leading compound of interest for use in the development of RAC/CDC42-activated kinase 1 (PAK1)-specific inhibitors for the treatment of various diseases/disorders, because PAK1 is not essential for the growth of normal cells. Interestingly, the new roles of mimosine in malignant glioma treatment, regenerative dentistry, and phytoremediation are being emerged. These identified properties indicate an exciting future for this amino acid. The present review is focused on the chemistry and recognized biological activities of mimosine in an attempt to draw a link between these two characteristics. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Mimosina/química
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
500-44-7 (Mimosine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5636


  3 / 290 MEDLINE  
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[PMID]:27163522
[Au] Autor:Retana-Márquez S; Juárez-Rojas L; Hernández A; Romero C; López G; Miranda L; Guerrero-Aguilera A; Solano F; Hernández E; Chemineau P; Keller M; Delgadillo JA
[Ad] Endereço:Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, México City C.P. 09340, Mexico. Electronic address: rems@xanum.uam.mx.
[Ti] Título:Comparison of the effects of mesquite pod and Leucaena extracts with phytoestrogens on the reproductive physiology and sexual behavior in the male rat.
[So] Source:Physiol Behav;164(Pt A):1-10, 2016 Oct 01.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mesquite (Prosopis sp.) and Leucaena leucocephala are widespread legumes, widely used to feed several livestock species and as food source for human populations in several countries. Both mesquite and Leucaena contain several phytoestrogens which might have potential estrogenic effects. Thus, the aim of this study was to evaluate the effects of mesquite pod and Leucaena extracts on several aspects of behavior and reproductive physiology of the male rat. The effects of the extracts were compared with those of estradiol (E2) and of two isoflavones: daidzein (DAI) and genistein (GEN). The following treatments were given to groups of intact male rats: vehicle; mesquite pod extract; Leucaena extract; E2; DAI; GEN. The results indicate that mesquite pod and Leucaena extracts disrupt male sexual behavior in a similar way to DAI and GEN, but less than E2. The main disruptor of sexual behavior was E2, however after 40 and 50days of administration, both extracts and phytoestrogens disrupted sexual behavior in a similar way to E2. The extracts also increased testicular germ cell apoptosis, decreased sperm quality, testicular weight, and testosterone levels, as phytoestrogens did, although these effects were less than those caused by estradiol. The number of seminiferous tubules with TUNEL-positive germ cells increased in extracts treated groups in a similar way to phytoestrogens groups, and E2 caused the greatest effect. The number of TUNEL-positive cells per tubule increased only in Leucaena extract and E2 groups, but not in mesquite- and phytoestrogens-treated groups. Spermatocytes and round spermatids were the TUNEL-positive cells observed in all experimental groups. This effect was associated with smaller testicular weights without atrophy in experimental groups compared with control. Testicular atrophy was only observed in estradiol-treated males. Testosterone decreased in males of all experimental groups, compared with control, this androgen was undetectable in E2 treated males. These results suggest that mesquite pod and Leucaena extracts cause effects similar to those of phytoestrogens in male rat reproduction, these effects were lower than those caused by E2.
[Mh] Termos MeSH primário: Mimosina/farmacologia
Fitoestrógenos/farmacologia
Reprodução/efeitos dos fármacos
Comportamento Sexual Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Peso Corporal/efeitos dos fármacos
Genisteína/farmacologia
Marcação In Situ das Extremidades Cortadas
Isoflavonas/farmacologia
Masculino
Extratos Vegetais/farmacologia
Prosopis/química
Ratos
Ratos Wistar
Espermatozoides
Testículo/efeitos dos fármacos
Testosterona/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isoflavones); 0 (Phytoestrogens); 0 (Plant Extracts); 3XMK78S47O (Testosterone); 500-44-7 (Mimosine); 6287WC5J2L (daidzein); DH2M523P0H (Genistein)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160511
[St] Status:MEDLINE


  4 / 290 MEDLINE  
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[PMID]:26843166
[Au] Autor:Negi VS; Borthakur D
[Ad] Endereço:Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, 1955 East West Road, Honolulu, HI, 96822, USA.
[Ti] Título:Heterologous Expression and Characterization of Mimosinase from Leucaena leucocephala.
[So] Source:Methods Mol Biol;1405:59-77, 2016.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Heterologous expression of eukaryotic genes in bacterial system is an important method in synthetic biology to characterize proteins. It is a widely used method, which can be sometimes quite challenging, as a number of factors that act along the path of expression of a transgene to mRNA, and mRNA to protein, can potentially affect the expression of a transgene in a heterologous system. Here, we describe a method for successful cloning and expression of mimosinase-encoding gene from Leucaena leucocephala (leucaena) in E. coli as the heterologous host. Mimosinase is an important enzyme especially in the context of metabolic engineering of plant secondary metabolite as it catalyzes the degradation of mimosine, which is a toxic secondary metabolite found in all Leucaena and Mimosa species. We also describe the methods used for characterization of the recombinant mimosinase.
[Mh] Termos MeSH primário: Enzimas/genética
Fabaceae/genética
Expressão Gênica
Proteínas de Plantas/genética
Proteínas Recombinantes
[Mh] Termos MeSH secundário: Clonagem Molecular
Ativação Enzimática
Enzimas/isolamento & purificação
Enzimas/metabolismo
Escherichia coli/genética
Escherichia coli/metabolismo
Fabaceae/metabolismo
Biblioteca Gênica
Mimosina/metabolismo
Proteínas de Plantas/isolamento & purificação
Proteínas de Plantas/metabolismo
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Enzymes); 0 (Plant Proteins); 0 (Recombinant Proteins); 500-44-7 (Mimosine)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-3393-8_7


  5 / 290 MEDLINE  
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[PMID]:26773324
[Au] Autor:Derakhshani H; Corley SW; Al Jassim R
[Ad] Endereço:School of Agriculture and Food Sciences, The University of Queensland, Gatton, Australia.
[Ti] Título:Isolation and characterization of mimosine, 3, 4 DHP and 2, 3 DHP degrading bacteria from a commercial rumen inoculum.
[So] Source:J Basic Microbiol;56(5):580-5, 2016 May.
[Is] ISSN:1521-4028
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The presence of the toxic amino acid mimosine in Leucaena leucocephala restricts its use as a protein source for ruminants. Rumen bacteria degrade mimosine to 3,4- and 2,3-dihydroxypyridine (DHP), which remain toxic. Synergistes jonesii is believed to be the main bacterium responsible for degradation of these toxic compounds but other bacteria may also be involved. In this study, a commercial inoculum provided by the Queensland's Department of Agriculture, Fisheries, and Forestry was screened for isolation and characterization of mimosine, 3,4- and 2,3-DHP degrading bacterial strains. A new medium for screening of 2,3-DHP degrading bacteria was developed. Molecular and biochemical approaches used in this study revealed four bacterial isolates - Streptococcus lutetiensis, Clostridium butyricum, Lactobacillus vitulinus, and Butyrivibrio fibrisolvens - to be able to completely degrade mimosine within 7 days of incubation. It was also observed that C. butyricum and L. vitulinus were able to partially degrade 2,3-DHP within 12 days of incubation, while S. lutetiensis, was able to fully degrade both 3,4 and 2,3 DHP. Collectively, we concluded that S. jonesii is not the sole bacterium responsible for detoxification of Leucaena. Comprehensive screening of rumen fluid of cattle grazing on Leucaena pastures is needed to identify additional mimosine-detoxifying bacteria and contribute to development of more effective inoculums to be used by farmers against Leucaena toxicity.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Fabaceae/metabolismo
Mimosina/metabolismo
Piridinas/metabolismo
Rúmen/microbiologia
[Mh] Termos MeSH secundário: Animais
Bactérias/isolamento & purificação
Bovinos
Fabaceae/toxicidade
Inativação Metabólica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pyridines); 500-44-7 (Mimosine); 7HY4BCJ130 (2,3-dihydroxypyridine); UW0C50CU4H (3,4-dihydroxypyridine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160117
[St] Status:MEDLINE
[do] DOI:10.1002/jobm.201500590


  6 / 290 MEDLINE  
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[PMID]:26744072
[Au] Autor:Kuroyanagi G; Otsuka T; Yamamoto N; Kainuma S; Ohguchi R; Fujita K; Matsushima-Nishiwaki R; Kozawa O; Tokuda H
[Ad] Endereço:Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
[Ti] Título:Mimosine suppresses the PGF2α-induced synthesis of osteoprotegerin but not interleukin-6 in osteoblasts.
[So] Source:Int J Mol Med;37(2):533-41, 2016 Feb.
[Is] ISSN:1791-244X
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Mimosine, a plant amino acid, is known to act as a normoxic inducer of hypoxia-inducible factor (HIF). Previous research has suggested that HIF plays important roles in angiogenesis-osteogenesis coupling and bone metabolism. We previously reported that prostaglandin F2α (PGF2α) induced osteoprotegerin synthesis through p38 mitogen-activated protein (MAP) kinase, p44/p42 MAP kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells. We have also demonstrated that PGF2α induced the synthesis of interleukin-6 (IL-6) via p38 MAP kinase and p44/p42 MAP kinase but not SAPK/JNK in these cells. In the present study, we investigated the effects of mimosine on the PGF2α-induced synthesis of osteoprotegerin or IL-6 in MC3T3-E1 cells. We found that deferoxamine, another inducer of HIF, as well as mimosine, upregulated the protein levels of HIF-1α. Both mimosine and deferoxamine significantly suppressed the PGF2α-induced release of osteoprotegerin, and the mRNA expression level, without markedly affecting PGF2α-induced IL-6 release. Both mimosine and deferoxamine, by themselves, induced the release of vascular endothelial growth factor. The phosphorylation of p38 MAP kinase, p44/p42 MAP kinase or SAPK/JNK induced by PGF2α was not markedly affected by either mimosine or deferoxamine. Thus, the results of the present study strongly suggest that mimosine, a normoxic inducer of HIF, inhibits the PGF2α­induced osteoprotegerin synthesis without affecting the IL-6 synthesis in osteoblasts.
[Mh] Termos MeSH primário: Desferroxamina/administração & dosagem
Dinoprosta/metabolismo
Interleucina-6/biossíntese
Mimosina/administração & dosagem
Osteoprotegerina/biossíntese
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/efeitos dos fármacos
Diferenciação Celular/genética
Linhagem Celular
Dinoprosta/administração & dosagem
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Fator 1 Induzível por Hipóxia/biossíntese
Interleucina-6/genética
MAP Quinase Quinase 4/biossíntese
Camundongos
Osteoblastos/efeitos dos fármacos
Osteoprotegerina/genética
Fragmentos de Peptídeos/biossíntese
RNA Mensageiro/biossíntese
Proteína Supressora de Tumor p53/biossíntese
Proteínas Quinases p38 Ativadas por Mitógeno/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypoxia-Inducible Factor 1); 0 (Interleukin-6); 0 (Osteoprotegerin); 0 (Peptide Fragments); 0 (RNA, Messenger); 0 (Tumor Suppressor Protein p53); 0 (p44 protein, mouse); 500-44-7 (Mimosine); B7IN85G1HY (Dinoprost); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 2.7.12.2 (MAP Kinase Kinase 4); J06Y7MXW4D (Deferoxamine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160109
[St] Status:MEDLINE
[do] DOI:10.3892/ijmm.2016.2452


  7 / 290 MEDLINE  
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[PMID]:26395911
[Au] Autor:Müller HD; Cvikl B; Janjic K; Nürnberger S; Moritz A; Gruber R; Agis H
[Ad] Endereço:Department of Prosthodontics, Medical University of Vienna, Vienna, Austria; Department of Preventive, Restorative and Pediatric Dentistry, University of Bern, Bern, Switzerland; Austrian Cluster for Tissue Regeneration, Vienna, Austria.
[Ti] Título:Effects of Prolyl Hydroxylase Inhibitor L-mimosine on Dental Pulp in the Presence of Advanced Glycation End Products.
[So] Source:J Endod;41(11):1852-61, 2015 Nov.
[Is] ISSN:1878-3554
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Proangiogenic prolyl hydroxylase (PHD) inhibitors represent a novel approach to stimulate tissue regeneration. Diabetes mellitus involves the accumulation of advanced glycation end products (AGEs). Here we evaluated the impact of AGEs on the response of human pulp tissue to the PHD inhibitor L-mimosine (L-MIM) in monolayer cultures of dental pulp-derived cells (DPCs) and tooth slice organ cultures. METHODS: In monolayer cultures, DPCs were incubated with L-MIM and AGEs. Viability was assessed based on formazan formation, live-dead staining, annexin V/propidium iodide, and trypan blue exclusion assay. Vascular endothelial growth factor (VEGF), interleukin (IL)-6, and IL-8 production was evaluated by quantitative polymerase chain reaction and immunoassays. Furthermore, expression levels of odontoblast markers were assessed, and alizarin red staining was performed. Tooth slice organ cultures were performed, and VEGF, IL-6, and IL8 levels in their supernatants were measured by immunoassays. Pulp tissue vitality and morphology were assessed by MTT assay and histology. RESULTS: In monolayer cultures of DPCs, L-MIM at nontoxic concentrations increased the production of VEGF and IL-8 in the presence of AGEs. Stimulation with L-MIM decreased alkaline phosphatase levels and matrix mineralization also in the presence of AGEs, whereas no significant changes in dentin matrix protein 1 and dentin sialophosphoprotein expression were observed. In tooth slice organ cultures, L-MIM increased VEGF but not IL-6 and IL-8 production in the presence of AGEs. The pulp tissue was vital, and no signs of apoptosis or necrosis were observed. CONCLUSIONS: Overall, in the presence of AGEs, L-MIM increases the proangiogenic capacity, but decreases alkaline phosphatase expression and matrix mineralization.
[Mh] Termos MeSH primário: Polpa Dentária/efeitos dos fármacos
Produtos Finais de Glicação Avançada
Mimosina/metabolismo
Inibidores de Prolil-Hidrolase/metabolismo
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Citocinas/biossíntese
Ensaio de Imunoadsorção Enzimática
Perfilação da Expressão Gênica
Seres Humanos
Imuno-Histoquímica
Modelos Biológicos
Técnicas de Cultura de Órgãos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (Glycation End Products, Advanced); 0 (Prolyl-Hydroxylase Inhibitors); 500-44-7 (Mimosine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:150924
[St] Status:MEDLINE


  8 / 290 MEDLINE  
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[PMID]:26389870
[Au] Autor:Nguyen BC; Chompoo J; Tawata S
[Ad] Endereço:Department of Bioscience and Biotechnology, The United Graduate School of Agricultural Sciences, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-8580, Japan. ncqbinh@gmail.com.
[Ti] Título:Insecticidal and Nematicidal Activities of Novel Mimosine Derivatives.
[So] Source:Molecules;20(9):16741-56, 2015 Sep 14.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Mimosine, a non-protein amino acid, is found in several tropical and subtropical plants, which has high value for medicine and agricultural chemicals. Here, in continuation of works aimed to development of natural product-based pesticidal agents, we present the first significant findings for insecticidal and nematicidal activities of novel mimosine derivatives. Interestingly, mimosinol and deuterated mimosinol (D-mimosinol) from mimosine had strong insecticidal activity which could be a result of tyrosinase inhibition (IC50 = 31.4 and 46.1 µM, respectively). Of synthesized phosphoramidothionate derivatives from two these amino alcohols, two compounds (1a and 1b) showed high insecticidal activity (LD50 = 0.5 and 0.7 µg/insect, respectively) with 50%-60% mortality at 50 µg/mL which may be attributed to acetylcholinesterase inhibition. Compounds 1a and 1b also had strong nematicidal activity with IC50 = 31.8 and 50.2 µM, respectively. Our results suggest that the length of the alkyl chain and the functional group at the C5-position of phosphoramidothionates derived from mimosinol and d-mimosinol are essential for the insecticidal and nematicidal activities. These results reveal an unexplored scaffold as new insecticide and nematicide.
[Mh] Termos MeSH primário: Antinematódeos/farmacologia
Caenorhabditis elegans/efeitos dos fármacos
Inseticidas/farmacologia
Mimosina/farmacologia
Praguicidas/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/química
Animais
Antinematódeos/química
Fabaceae/química
Inseticidas/química
Mimosina/química
Praguicidas/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents); 0 (Insecticides); 0 (Pesticides); 0 (Plant Extracts); 500-44-7 (Mimosine); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150922
[St] Status:MEDLINE
[do] DOI:10.3390/molecules200916741


  9 / 290 MEDLINE  
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[PMID]:26287130
[Au] Autor:Nguyen BC; Tawata S
[Ad] Endereço:Department of Bioscience and Biotechnology, The United Graduate School of Agricultural Sciences, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-8580, Japan. ncqbinh@gmail.com.
[Ti] Título:Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase.
[So] Source:Molecules;20(8):14334-47, 2015 Aug 06.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Melanogenesis plays an important role in the protection of skin against UV through production of melanin pigments, but abnormal accumulation of this pigment causes unaesthetic hyperpigmentation. Much effort is being made to develop effective depigmenting agents. Here, we show for the first time that a small library of mimosine dipeptide enantiomers (Mi-L/D-amino acid) inhibit the melanogenesis in B16F10 melanoma cells by down-regulating the cellular tyrosinase with little effect on their growth or viability. Two of them, Mi-D-Trp and Mi-D-Val, turned out to be the most potent inhibitors on melanin content and cellular tyrosinase in B16F10 melanoma cells. In addition, most of the mimosine dipeptides were more potent than mimosine for inhibiting cyclooxygenase 1 (COX-1) with IC50 of 18-26 µM. Among them, Mi-L-Val and Mi-L-Trp inhibited cyclooxygenase 2 (COX-2) more potently than indomethacin, with IC50 values of 22 and 19 µM, respectively. Taken together, our results suggest the possibility that mimosine dipeptides could be better candidates (than mimosine) for anti-melanogenic (skin hyperpigmentation treatment) and cyclooxygenase (COX) inhibition.
[Mh] Termos MeSH primário: Inibidores de Ciclo-Oxigenase/química
Inibidores de Ciclo-Oxigenase/farmacologia
Dipeptídeos/química
Dipeptídeos/farmacologia
Melaninas/antagonistas & inibidores
Mimosina/análogos & derivados
Mimosina/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Relação Dose-Resposta a Droga
Regulação para Baixo
Hiperpigmentação/tratamento farmacológico
Melaninas/biossíntese
Melanoma Experimental/tratamento farmacológico
Melanoma Experimental/enzimologia
Melanoma Experimental/metabolismo
Camundongos
Mimosina/química
Monofenol Mono-Oxigenase/antagonistas & inibidores
Monofenol Mono-Oxigenase/metabolismo
Prostaglandina-Endoperóxido Sintases/química
Prostaglandina-Endoperóxido Sintases/metabolismo
Transdução de Sinais/efeitos dos fármacos
Pele/metabolismo
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclooxygenase Inhibitors); 0 (Dipeptides); 0 (Melanins); 500-44-7 (Mimosine); EC 1.14.18.1 (Monophenol Monooxygenase); EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150820
[Lr] Data última revisão:
150820
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150820
[St] Status:MEDLINE
[do] DOI:10.3390/molecules200814334


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[PMID]:26210396
[Au] Autor:Bottini-Luzardo M; Aguilar-Perez C; Centurion-Castro F; Solorio-Sanchez F; Ayala-Burgos A; Montes-Perez R; Muñoz-Rodriguez D; Ku-Vera J
[Ad] Endereço:Faculty of Veterinary Medicine and Animal Science, University of Yucatan, Carretera Merida-Xmatkuil Km. 15.5, 97100, Merida, Yucatan, Mexico. mariabluzardo@yahoo.es.
[Ti] Título:Ovarian activity and estrus behavior in early postpartum cows grazing Leucaena leucocephala in the tropics.
[So] Source:Trop Anim Health Prod;47(8):1481-6, 2015 Dec.
[Is] ISSN:1573-7438
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The legume Leucaena leucocephala (Leucaena) is widely used to supplement forage in silvopastoral livestock systems in Latin America. Little is known about its possible effects on the cow reproductive dynamic. The aim was to evaluate the effect of Leucaena foliage intake on re-establishment of ovarian activity and estrus behavior in early postpartum (7-90 days) cows. Twenty-four multiparous Bos taurus × Bos indicus cows were divided into two homogenous groups and assigned to one of two treatments: a silvopastoral system (SS, n = 12), consisting of an association of Cynodon nlemfuensis grass and L. leucocephala; and a control system (CS, n = 12), consisting of C. nlemfuensis alone. Intake of Leucaena in the SS ranged from 3.80 to 6.43 kg DM/cow/day. Plasma mimosine concentrations ranged from 1270 to 1530 µg/mL, and those for 2,3-dihydroxypyridine (DHP) from 147 to 729 µg/mL. No 3,4-DHP was detected in plasma. No difference (P > 0.05) between treatments was observed for the number of cows exhibiting small, medium, or dominant follicles, or estrus behavior. The number of cows which re-established ovarian cyclicity (n = 6) was lower (P < 0.05) in the SS than in the CS (n = 9). Corpus luteum lifespan was longer (P < 0.05) in the SS than in the CS. Intake of Leucaena affected the number of cows exhibiting ovarian cyclicity and extended corpus luteum life, but did not affect follicular development and estrus behavior.
[Mh] Termos MeSH primário: Corpo Lúteo/efeitos dos fármacos
Ciclo Estral/efeitos dos fármacos
Fabaceae
Mimosina/efeitos adversos
Reprodução
[Mh] Termos MeSH secundário: Ração Animal/efeitos adversos
Ração Animal/estatística & dados numéricos
Animais
Nitrogênio da Ureia Sanguínea
Bovinos
Dieta/veterinária
Suplementos Nutricionais
Estro
Feminino
Ovário/efeitos dos fármacos
Paridade
Período Pós-Parto
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
500-44-7 (Mimosine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150727
[St] Status:MEDLINE
[do] DOI:10.1007/s11250-015-0887-3



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