Base de dados : MEDLINE
Pesquisa : D03.383.725.812 [Categoria DeCS]
Referências encontradas : 237 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 24 ir para página                         

  1 / 237 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25548768
[Au] Autor:Alkuraishy HM; Al-Gareeb AI; Albuhadilly AK
[Ad] Endereço:Department of Pharmacology, Toxicology and Medicine, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.
[Ti] Título:Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders­a randomized controlled clinical study.
[So] Source:Biomed Res Int;2014:324307, 2014.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors. Thirty patients (twenty males + ten females) with age range 50-65 years, normotensive with history of cerebrovascular disorders, were selected according to the American Heart Stroke Association. Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P < 0.05), especially on low shear whole blood viscosity (P < 0.01), but they produced insignificant effects on total serum protein and high shear whole blood viscosity (P > 0.05). Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders.
[Mh] Termos MeSH primário: Viscosidade Sanguínea/efeitos dos fármacos
Transtornos Cerebrovasculares/tratamento farmacológico
Piritioxina/administração & dosagem
Alcaloides de Vinca/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Proteínas Sanguíneas/biossíntese
Transtornos Cerebrovasculares/sangue
Transtornos Cerebrovasculares/fisiopatologia
Sinergismo Farmacológico
Eritrócitos
Feminino
Seres Humanos
Masculino
Meia-Idade
Ensaios Clínicos Controlados Aleatórios como Assunto
Reologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Vinca Alkaloids); 543512OBTC (vinpocetine); AK5Q5FZH2R (Pyrithioxin)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141231
[St] Status:MEDLINE
[do] DOI:10.1155/2014/324307


  2 / 237 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25026346
[Au] Autor:Jebasingh D; Devavaram Jackson D; Venkataraman S; Adeghate E; Starling Emerald B
[Ad] Endereço:Department of Pharmacology, CL Baid Metha Foundation for Pharmaceutical Education and Research , Thoraipakkam, Chennai, Tamil Nadu , India .
[Ti] Título:The protective effects of Cyperus rotundus on behavior and cognitive function in a rat model of hypoxia injury.
[So] Source:Pharm Biol;52(12):1558-69, 2014 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Hypoxia injury (HI) with its long-term neurological complications is one of the leading causes of morbidity and mortality in the world. Currently, the treatment regimens for hypoxia are aimed only at ameliorating the damage without complete cure. The need, therefore, for novel therapeutic drugs to treat HI continues. OBJECTIVE: This study investigates the protective effects of the ethanol extract of Cyperus rotundus L. (Cyperaceae) (EECR), a medicinal plant used in Ayurvedic traditional medicine against sodium nitrite-induced hypoxia in rats. MATERIALS AND METHODS: We have evaluated the protective effect of 200 and 400 mg/kg of EECR against sodium nitrite-induced hypoxia injury in rats by assessing the cognitive functions, motor, and behavioral effects of EECR treatment along with the histological changes in the brain. By comparing the protective effects of standard drugs galantamine, a reversible cholinesterase inhibitor and pyritinol, an antioxidant nootropic drug against sodium nitrite-induced hypoxia in rats, we have tested the protective ability of EECR. RESULTS: EECR at doses of 200 and 400 mg/kg was able to protect against the cognitive impairments, and the locomotor activity and muscular coordination defects, which are affected by sodium nitrite-induced hypoxia injury in rats. CONCLUSION: Based on our results, we suggest that the medicinal herb C. rotundus possesses a protective effect against sodium nitrite-induced hypoxia in rats. Further studies on these protective effects of EECR may help in designing better therapeutic regimes for hypoxia injury.
[Mh] Termos MeSH primário: Transtornos Cognitivos/prevenção & controle
Cyperus/química
Hipóxia/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Transtornos Cognitivos/etiologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Galantamina/farmacologia
Hipóxia/complicações
Masculino
Medicina Ayurvédica
Atividade Motora/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
Piritioxina/farmacologia
Ratos
Ratos Wistar
Nitrito de Sódio/toxicidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0D3Q044KCA (Galantamine); AK5Q5FZH2R (Pyrithioxin); M0KG633D4F (Sodium Nitrite)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140716
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2014.908395


  3 / 237 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:23330199
[Au] Autor:Zavadenko NN; Kozlova EV; Koltunov IE
[Ti] Título:[Developmental dysphasia: assessment of the drug treatment efficacy].
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;112(7 Pt 2):90-5, 2012.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:To assess the efficacy of treatment with encephabol, we examined 40 children, aged from 3 to 5 years, with developmental dysphasia. All patients were randomized into two equal groups: group 1 received encephabol (suspension form, daily dosage 200-250 mg, or 12-15 mg/kg) during 2 months; group 2 did not receive this medication. In the first group, there was a significant improvement of expressive and impressive speech and speech attention; the active vocabulary and a number of phrases in colloquial speech increased by a factor of 3 versus 1.5 in the control group. After the treatment with encephabol, the parents reported the decrease in motor disturbances, psychosomatic disorders, the improvement of attention and the emotional state of the children.
[Mh] Termos MeSH primário: Afasia/tratamento farmacológico
Transtornos do Desenvolvimento da Linguagem/tratamento farmacológico
Desenvolvimento da Linguagem
Piritioxina/uso terapêutico
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seres Humanos
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
AK5Q5FZH2R (Pyrithioxin)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130119
[St] Status:MEDLINE


  4 / 237 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:23120794
[Au] Autor:Zenkov LR; Zenkova AL
[Ti] Título:[Encephabol in the treatment of cognitive disorders in epilepsy].
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;111(5 Pt 2):77-80, 2011.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Cognitive disorders in patients with epilepsy were studied before and after the 6-week treatment with encephabol. The data on the examination of 24 patients were summarized. Before the treatment, patients with epilepsy demonstrated a larger number of errors, lower speed of reading and worse learning of the content compared to the controls (18 healthy people). Encephabol was prescribed in dosage 600 mg/day to people over 12 years of age and in dosage 300-400 mg/day to people younger than 12 years. The statistically significant improvement of the global self-rating of cognitive functions, speed of reading, decrease of errors as well as learning of the content were seen after the end of treatment. The improvement of cognitive traits was correlated with the improvement of computed EEG parameters (the decrease of delta power in the right temporal and frontal regions). Encephabol did not lead to the increase of epileptiform activity in the EEG. No increase in the number and severity of seizures was noted. In conclusion, encephabol may be used in treatment of cognitive disorders in epilepsy.
[Mh] Termos MeSH primário: Transtornos Cognitivos/tratamento farmacológico
Transtornos Cognitivos/etiologia
Epilepsia/complicações
Piritioxina/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Eletroencefalografia
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Piritioxina/administração & dosagem
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
AK5Q5FZH2R (Pyrithioxin)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121103
[St] Status:MEDLINE


  5 / 237 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:22027605
[Au] Autor:Chutko LS; Surushkina SIu; Iakovenko EA; Bykova IuL; Nikishena IS
[Ti] Título:[Efficacy of cortexin in the treatment of memory disorders in children].
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;111(9 Pt 2):37-40, 2011.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Children, aged from 7 to 12 years, with memory disorders were treated with cortexin (30 patients) and encephabol (30 patients). The comparative evaluation of efficacy and safety of these drugs was carried out. The higher cortexin efficacy (the improvement in 86.7% of cases) in comparison with encephabol (the improvement in 63.3% of cases) confirmed by the data of neuropsychological and neurophysiological research is established.
[Mh] Termos MeSH primário: Transtornos da Memória/tratamento farmacológico
Peptídeos/uso terapêutico
Piritioxina/uso terapêutico
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
Masculino
Transtornos da Memória/fisiopatologia
Peptídeos/efeitos adversos
Piritioxina/efeitos adversos
Ritmo Teta
[Pt] Tipo de publicação:COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Peptides); 83270-84-2 (cortexin); AK5Q5FZH2R (Pyrithioxin)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111027
[St] Status:MEDLINE


  6 / 237 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:20355200
[Au] Autor:El-Sayed MA; Abdul-Azim Mohammad M
[Ad] Endereço:Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kaser El-Aini Street, ET 11562, Cairo, Egypt.
[Ti] Título:Stability-indicating chemometric methods for the determination of pyritinol dihydrochloride.
[So] Source:Drug Test Anal;1(5):228-33, 2009 May.
[Is] ISSN:1942-7611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three multivariate calibration methods, including classical least square with nonzero intercept (CLS), principal component regression (PCR) and partial least square (PLS), have been used for the determination of pyritinol dihydrochloride in the presence of its degradation product. The CLS, PCR and PLS techniques are useful in spectral analysis because the simultaneous inclusion of many spectral wavelengths instead of the single wavelength used in derivative spectrophotometry has greatly improved the precision and predictive abilities of these multivariate calibrations. A training set was constructed for the mixture and the best model was used for the prediction of the concentration of the selected drug. The proposed procedures were applied successfully in the determination of pyritinol dihydrochloride in laboratory-prepared mixtures and in commercial preparations. Pyritinol dihydrochloride was analysed with mean accuracies 99.99 +/- 0.905, 99.91 +/- 0.966 and 99.92 +/- 0.962 using the CLS, PCR and PLS methods respectively. The validity of the proposed methods was assessed using the standard addition technique. The proposed procedures were found to be rapid and simple and required no preliminary separation. They can therefore be used for the routine analysis of pyritinol dihydrochloride in quality-control laboratories.
[Mh] Termos MeSH primário: Piritioxina/análise
[Mh] Termos MeSH secundário: Calibragem
Estabilidade de Medicamentos
Análise dos Mínimos Quadrados
Análise de Componente Principal
Piritioxina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
AK5Q5FZH2R (Pyrithioxin)
[Em] Mês de entrada:1006
[Cu] Atualização por classe:160511
[Lr] Data última revisão:
160511
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100401
[St] Status:MEDLINE
[do] DOI:10.1002/dta.37


  7 / 237 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:19279367
[Au] Autor:Nair MK; George B; Jeyaseelan L
[Ad] Endereço:Child Development Centre, Medical College, Thiruvananthapuram, Kerala, India. nairmkc@rediffmail.com
[Ti] Título:Pyritinol for post asphyxial encephalopathy in term babies-- a randomized double-blind controlled trial.
[So] Source:Indian Pediatr;46 Suppl:s37-42, 2009 Jan.
[Is] ISSN:0019-6061
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the efficacy of pyritinol in improving the neurodevelopmental outcome at one year of age among term babies with post-asphyxial encephalopathy. SETTING: Level II Neonatal Nursery and Child Development Centre, Medical College, Thiruvananthapuram. DESIGN: Randomised placebo controlled double blind trial. PARTICIPANTS: 108 term babies with post-asphyxial encephalopathy, stratified into three grades based on clinical criteria. INTERVENTION: The treatment group (n=54) received pyritinol and the control group (n=54) received placebo, in exactly the same increasing dosage schedule of 1 to 5 mL liquid drug (20-100 mg) from 8th postnatal day until the end of six months. OUTCOME VARIABLES: Mean Mental Development Index (MDI) and mean Psychomotor Development Index (PDI) measured on Bayley Scales of Infant Development at one year of age. RESULTS: No statistically significant difference was observed in MDI or PDI scores at one year between the treatment and control groups. The confidence interval for the differences ranged from -6.3 to 8.7 for MDI and from - 4.1 to 12.7 for PDI. On multiple regression analysis using one year MDI and PDI scores, even after controlling for birthweight, there was no statistically significant difference between the treatment and control groups. CONCLUSION: Pyritinol is not useful in improving the neurodevelopmental status of babies with post-asphyxial encephalopathy at one year of age.
[Mh] Termos MeSH primário: Asfixia Neonatal/complicações
Hipóxia Encefálica/tratamento farmacológico
Piritioxina/uso terapêutico
[Mh] Termos MeSH secundário: Desenvolvimento Infantil
Método Duplo-Cego
Feminino
Seres Humanos
Hipóxia Encefálica/etiologia
Lactente
Recém-Nascido
Masculino
Nascimento a Termo
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
AK5Q5FZH2R (Pyrithioxin)
[Em] Mês de entrada:0906
[Cu] Atualização por classe:140730
[Lr] Data última revisão:
140730
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090313
[St] Status:MEDLINE


  8 / 237 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:18593582
[Au] Autor:Jiménez-Andrade GY; Reyes-García G; Sereno G; Ceballos-Reyes G; Vidal-Cantú GC; Granados-Soto V
[Ad] Endereço:Escuela de Biología, Benemérita Universidad Autónoma de Puebla, Puebla, Puebla, Mexico.
[Ti] Título:Pyritinol reduces nociception and oxidative stress in diabetic rats.
[So] Source:Eur J Pharmacol;590(1-3):170-6, 2008 Aug 20.
[Is] ISSN:0014-2999
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to assess the antinociceptive and antiallodynic effect of pyritinol as well as its possible mechanism of action in diabetic rats. Streptozotocin (50 mg/kg) injection caused hyperglycemia within 1 week. Formalin-evoked flinching was increased in diabetic rats as compared to non-diabetic rats. Oral acute administration of pyritinol (50-200 mg/kg) dose-dependently reduced flinching behavior in diabetic rats. Moreover, prolonged administration of pyritinol (12.5-50 mg/kg, every 2 days for 2 weeks) reduced formalin-induced nociception. 1H-[1,2,4]-oxadiazolo [4,3-a] quinoxalin-1-one (ODQ, a guanylyl cyclase inhibitor, 2 mg/kg, i.p.), but not naltrexone (a non-selective opioid receptor antagonist, 1 mg/kg, s.c.) or indomethacin (a non-selective cycloxygenase inhibitor, 5 mg/kg, i.p.), blocked the pyritinol-induced antinociception in diabetic rats. Given alone ODQ, naltrexone or indomethacin did not modify formalin-induced nociception in diabetic rats. Oral acute (200 mg/kg) or prolonged (25 mg/kg, every 2 days for 2 weeks) administration of pyritinol significantly reduced streptozotocin-induced changes in free carbonyls, dityrosine, malondialdehyde and advanced oxidative protein products. Four to 8 weeks after diabetes induction, tactile allodynia was observed in the streptozotocin-injected rats. On this condition, oral administration of pyritinol (50-200 mg/kg) reduced tactile allodynia in diabetic rats. Results indicate that pyritinol is able to reduce formalin-induced nociception and tactile allodynia in streptozotocin-injected rats. In addition, data suggest that activation of guanylyl cyclase and the scavenger properties of pyritinol, but not improvement in glucose levels, play an important role in these effects.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Diabetes Mellitus Experimental/fisiopatologia
Estresse Oxidativo/efeitos dos fármacos
Piritioxina/farmacologia
[Mh] Termos MeSH secundário: Animais
Feminino
Indometacina/farmacologia
Naltrexona/farmacologia
Oxidiazóis/farmacologia
Quinoxalinas/farmacologia
Ratos
Ratos Wistar
Estreptozocina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one); 0 (Analgesics); 0 (Oxadiazoles); 0 (Quinoxalines); 5S6W795CQM (Naltrexone); 5W494URQ81 (Streptozocin); AK5Q5FZH2R (Pyrithioxin); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:0810
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080703
[St] Status:MEDLINE
[do] DOI:10.1016/j.ejphar.2008.06.050


  9 / 237 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:17202801
[Au] Autor:El-Bardicy MG; Lotfy HM; El-Sayed MA; El-Tarras MF
[Ad] Endereço:Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
[Ti] Título:Stability-indicating electrochemical methods for the determination of meclophenoxate hydrochloride and pyritinol dihydrochloride using ion-selective membrane electrodes.
[So] Source:Yakugaku Zasshi;127(1):201-8, 2007 Jan.
[Is] ISSN:0031-6903
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The construction and electrochemical response characteristics of polyvinyl chloride (PVC) membrane sensors for the determination of meclophenoxate hydrochloride (I) and pyritinol dihydrochloride (II) in presence of their degradation products are described. The sensors are based on the use of the ion-association complexes of (I) and (II) cation with sodium tetraphenyl borate and ammonium reineckate counteranions as ion-exchange sites in the PVC matrix. In addition beta-cyclodextrin (beta-CD) membranes were used in the determination of I and II. These ion pairs and beta-CD were then incorporated as electroactive species with ortho nitrophenyl octyl ether (oNPOE) as a plasticizer. Three PVC sensors were fabricated for each drug, i.e. meclophenoxate tetraphenyl borate (meclo-TPB), meclophenoxate reineckate (meclo-RNC) and meclophenoxate beta-cyclodextrin (meclo-beta-CD), and the same was done for pyritinol (pyrit-TPB), (pyrit-RNC) and (pyrit-beta-CD). They showed near Nernestian responses for meclophenoxate over the concentration range 10(-5)-10(-2) with slopes of 52.73, 51.64 and 54.05 per concentration decade with average recoveries of 99.92+/-1.077, 99.96+/-0.502 and 100.03+/-0.763 for meclo-TPB, meclo-RNC and meclo-beta-CD respectively. Pyritinol also showed near Nernestian responses over the concentration range of 3.162 x 10(-6) - 3.162 x 10(-4) for pyrit-TPB and pyrit-RNC, and 10(-6) - 3.162 x 10(-4) for pyrit-beta-CD with slopes of 30.60, 31.10 and 32.89 per concentration decade and average recoveries of 99.99+/-0.827, 100.00+/-0.775 and 99.99+/-0.680 for pyrit-TPB, pyrit-RNC and pyrit-beta-CD respectively. The sensors were used successfully for the determination of I and II in laboratory prepared mixtures with their degradation products, in pharmaceutical dosage forms and in plasma.
[Mh] Termos MeSH primário: Eletroquímica/métodos
Eletrodos Íon-Seletivos
Meclofenoxate/análise
Piritioxina/análise
[Mh] Termos MeSH secundário: Formas de Dosagem
Cloreto de Polivinila
beta-Ciclodextrinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dosage Forms); 0 (beta-Cyclodextrins); 9002-86-2 (Polyvinyl Chloride); AK5Q5FZH2R (Pyrithioxin); C76QQ2I0RG (Meclofenoxate); JV039JZZ3A (betadex)
[Em] Mês de entrada:0703
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070105
[St] Status:MEDLINE


  10 / 237 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:15759729
[Au] Autor:Shehata MA; el-Sayed MA; el-Bardicy MG; el-Tarras MF
[Ad] Endereço:Cairo University, Faculty of Pharmacy, Department of Analytical Chemistry, Kaser El-Aini St, ET 11562, Cairo, Egypt. mostafa1960@yahoo.com
[Ti] Título:Stability-indicating methods for determination of pyritinol dihydrochloride in the presence of its precursor and degradation product by derivative spectrophotometry.
[So] Source:J AOAC Int;88(1):80-6, 2005 Jan-Feb.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A first-derivative spectrophotometric (1D) method and a derivative-ratio zero-crossing spectrophotometric (1DD) method were used to determine pyritinol dihydrochloride (I) in the presence of its precursor (II) and its degradation product (III) with 0.1N hydrochloric acid as a solvent. Linear relationships were obtained in the ranges of 6-22 microg/mL for the (1D) method and 6-20 microg/mL for the (1DD) method. By applying the proposed methods, it was possible to determine pyritinol dihydrochloride in its pure powdered form with an accuracy of 100.36 +/- 1.497% (n = 9) for the (1D) method and an accuracy of 99.92 +/- 1.172% (n = 8) for the (1DD) method. Laboratory-prepared mixtures containing different ratios of (I), (II), and (III) were analyzed, and the proposed methods were valid for concentrations of < or = 10% (II) and < or = 50% (III). The proposed methods were validated and found to be suitable as stability-indicating assay methods for pyritinol in pharmaceutical formulations.
[Mh] Termos MeSH primário: Técnicas de Química Analítica/métodos
Cloretos/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Preparações Farmacêuticas/análise
Piritioxina/análogos & derivados
Piritioxina/análise
Piritioxina/química
[Mh] Termos MeSH secundário: Cloretos/química
Cromatografia Gasosa
Relação Dose-Resposta a Droga
Espectrometria de Massas
Modelos Químicos
Sensibilidade e Especificidade
Espectrofotometria
Fatores de Tempo
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Pharmaceutical Preparations); AK5Q5FZH2R (Pyrithioxin)
[Em] Mês de entrada:0507
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050312
[St] Status:MEDLINE



página 1 de 24 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde