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[PMID]:28471102
[Au] Autor:Yoo SG; Cho MJ; Kim US; Baek SH
[Ad] Endereço:Department of Ophthalmology, Kim's Eye Hospital, Seoul, Korea.
[Ti] Título:Cycloplegic Refraction in Hyperopic Children: Effectiveness of a 0.5% Tropicamide and 0.5% Phenylephrine Addition to 1% Cyclopentolate Regimen.
[So] Source:Korean J Ophthalmol;31(3):249-256, 2017 Jun.
[Is] ISSN:2092-9382
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the effectiveness of a cycloplegic regimen using 0.5% tropicamide and 0.5% phenylephrine (Tropherine, Hanmi Pharm), in addition to 1% cyclopentolate, in hyperopic children. METHODS: The medical records of hyperopic patients below the age of 14 years who had undergone cycloplegic retinoscopy were retrospectively reviewed. Cycloplegic refractions were performed using one of two cycloplegic regimens. Regimen 1 was a Tropherine-added regimen comprising the administration of one drop of 1% cyclopentolate followed by two to three drops of Tropherine added at 15-minute intervals. Regimen 2 was a cyclopentolate-only regimen comprising the administration of three to four drops of 1% cyclopentolate at 15-minute intervals. The mean difference between noncycloplegic and cycloplegic refraction was compared between the two regimens. RESULTS: A total of 308 eyes of 308 hyperopic children were included. The mean difference (±standard deviation) in the spherical equivalent (SE) between cycloplegic and noncycloplegic refraction was significantly larger in regimen 2 than in regimen 1, with values of +1.70 ± 1.03 diopters (D) and +1.25 ± 0.89 D, respectively (p=0.001). The SE change after cycloplegia was significantly different between the two regimens only in patients aged 5 years or younger (p=0.001), particularly in those with high hyperopia with an SE ≥5 D (p=0.005) or fully accommodative esotropia (p=0.009). There was no significant difference between the two regimens in patients older than 5 years, regardless of the presence of high hyperopia or fully accommodative esotropia. CONCLUSIONS: The Tropherine-added regimen exerted a weaker cycloplegic effect than the cyclopentolate-only regimen, particularly in children under the age of 5 years with high hyperopia or fully accommodative esotropia. However, the difference in refraction between the two regimens was small. A Tropherine-added regimen can be effective in hyperopic children, with less associated discomfort than the instillation of cyclopentolate.
[Mh] Termos MeSH primário: Acomodação Ocular/efeitos dos fármacos
Ciclopentolato/administração & dosagem
Oftalmopatias Hereditárias/tratamento farmacológico
Hiperopia/tratamento farmacológico
Fenilefrina/administração & dosagem
Refração Ocular/efeitos dos fármacos
Tropicamida/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Quimioterapia Combinada
Oftalmopatias Hereditárias/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Hiperopia/fisiopatologia
Lactente
Recém-Nascido
Masculino
Midriáticos/administração & dosagem
Soluções Oftálmicas/administração & dosagem
Estudos Retrospectivos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); 0 (Ophthalmic Solutions); 1WS297W6MV (Phenylephrine); I76F4SHP7J (Cyclopentolate); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2016.0007


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[PMID]:29233124
[Au] Autor:Lyu IJ; Park KA; Oh SY
[Ad] Endereço:Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
[Ti] Título:Increase in esodeviation under cycloplegia with 0.5% tropicamide and 0.5% phenylephrine mixed eye drops in patients with hyperopia and esotropia.
[So] Source:BMC Ophthalmol;17(1):247, 2017 Dec 12.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUD: To evaluate the manifestations of increased esodeviation under cycloplegia with 0.5% tropicamide and 0.5% phenylephrine in children with hyperopia and esotropia. METHODS: We reviewed the medical record of 34 children with hyperopia and esotropia who underwent a prism alternate cover test before and after instillation of mixed eye drops containing 0.5% tropicamide and 0.5% phenylephrine between November 2014 and October 2015. Increased angle of deviation was defined as 10 prism diopters (PD) or greater deviation after cycloplegia. The factors related to increased angle of deviation were evaluated using univariable and multivariable logistic regression analysis. RESULTS: The median age was 5.0 years (interquartile range, 3.75 to 5.0) and 12 patients (35.3%) were male. The median manifested refractive (MR) was +2.13 diopters (D) (+0.92 to +4.47) and cycloplegic refractive (CR) was +3.50 D (+1.72 to +5.66). The median difference between MR and CR was +0.88 D (+0.50 to +1.28). Thirteen patients (38.2%) showed increased esodeviation under cycloplegia and all had accommodative esotropia. A larger difference between MR and CR was the only significant factor affecting increased esodeviation in both univariable (OR = 4.72, P = 0.029) and multivariable (OR = 5.22, P = 0.047) analyses. CONCLUSION: Children with hyperopia and esotropia often showed an increased angle of deviation after instillation of 0.5% tropicamide and 0.5% phenylephrine. This phenomenon reminded the clinicians that cycloplegics can have a different effect on esodeviation and suggested that increased angle of esodeviation may help to reveal the latent deviation in some patients with hyperopia and esotropia.
[Mh] Termos MeSH primário: Esotropia/tratamento farmacológico
Hiperopia/tratamento farmacológico
Midriáticos/uso terapêutico
Fenilefrina/uso terapêutico
Refração Ocular/efeitos dos fármacos
Tropicamida/uso terapêutico
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Esotropia/fisiopatologia
Seres Humanos
Hiperopia/fisiopatologia
Modelos Logísticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); 1WS297W6MV (Phenylephrine); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0644-7


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[PMID]:28822760
[Au] Autor:Lopez NN; Patel GC; Raychaudhuri U; Aryal S; Phan TN; Clark AF; Millar JC
[Ad] Endereço:North Texas Eye Research Institute (NTERI), University of North Texas Health Science Center (UNTHSC), 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
[Ti] Título:Anterior chamber perfusion versus posterior chamber perfusion does not influence measurement of aqueous outflow facility in living mice by constant flow infusion.
[So] Source:Exp Eye Res;164:95-108, 2017 Nov.
[Is] ISSN:1096-0007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mice are now routinely utilized in studies of aqueous humor outflow dynamics. In particular, conventional aqueous outflow facility (C) is routinely measured via perfusion of the aqueous chamber by a number of laboratories. However, in mouse eyes perfused ex-vivo, values for C are variable depending upon whether the perfusate is introduced into the posterior chamber (PC) versus the anterior chamber (AC). Perfusion via the AC leads to posterior bowing of the iris, and traction on the iris root/scleral spur, which may increase C. Perfusion via the PC does not yield this effect. But the equivalent situation in living mice has not been investigated. We sought to determine whether AC versus PC perfusion of the living mouse eye may lead to different values for C. All experiments were conducted in C57BL/6J mice (all ♀) between the ages of 20 and 30 weeks. Mice were divided into groups of 3-4 animals each. In all groups, both eyes were perfused. C was measured in groups 1 and 2 by constant flow infusion (from a 50 µL microsyringe) via needle placement in the AC, and in the PC, respectively. To investigate the effect of ciliary muscle (CM) tone on C, groups 3 and 4 were perfused live via the AC or PC with tropicamide (muscarinic receptor antagonist) added to the perfusate at a concentration of 100 µM. To investigate immediate effect of euthanasia, groups 5 and 6 were perfused 15-30 min after death via the AC or PC. To investigate the effect of CM tone on C immediately following euthanasia, groups 7 and 8 were perfused 15-30 min after death via the AC or PC with tropicamide added to the perfusate at a concentration of 100 µM. C in Groups 1 (AC perfusion) and 2 (PC perfusion) was computed to be 19.5 ± 0.8 versus 21.0 ± 2.1 nL/min/mmHg, respectively (mean ± SEM, p > 0.4, not significantly different). In live animals in which tropicamide was present in the perfusate, C in Group 3 (AC perfusion) was significantly greater than C in Group 4 (PC perfusion) (22.0 ± 4.0 versus 14.0 ± 2.0 nL/min/mmHg, respectively, p = 0.0021). In animals immediately following death, C in groups 5 (AC perfusion) and 6 (PC perfusion) was computed to be 21.2 ± 2.0 versus 22.8 ± 1.4 nL/min/mmHg, respectively (mean ± SEM, p = 0.1196, not significantly different). In dead animals in which tropicamide was present in the perfusate, C in group 7 (AC perfusion) was greater than C in group 8 (PC perfusion) (20.6 ± 1.4 versus 14.2 ± 2.6 nL/min/mmHg, respectively, p < 0.0001). C in eyes in situ in living mice or euthanized animals within 15-30 min post mortem is not significantly different when measured via AC perfusion or PC perfusion. In eyes of live or freshly euthanized mice, C is greater when measured via AC versus PC perfusion when tropicamide (a mydriatic and cycloplegic agent) is present in the perfusate.
[Mh] Termos MeSH primário: Câmara Anterior/fisiologia
Humor Aquoso/fisiologia
Pressão Intraocular/fisiologia
Segmento Posterior do Olho/fisiologia
[Mh] Termos MeSH secundário: Animais
Câmara Anterior/efeitos dos fármacos
Câmara Anterior/metabolismo
Humor Aquoso/metabolismo
Modelos Animais de Doenças
Feminino
Pressão Intraocular/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Antagonistas Muscarínicos/farmacologia
Segmento Posterior do Olho/efeitos dos fármacos
Segmento Posterior do Olho/metabolismo
Malha Trabecular/metabolismo
Tropicamida/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Muscarinic Antagonists); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170821
[St] Status:MEDLINE


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[PMID]:28727614
[Au] Autor:Denion E; Charlot F; Béraud G
[Ad] Endereço:1Centre Ophtalmologique du Pays des Olonnes (COPO), Les Sables-d'Olonne, France 2Service d'Ophtalmologie, Polyclinique de la Baie, Saint-Martin-des-Champs, France 3Médecine Interne et Maladies Infectieuses, Poitiers, France 4Université Droit et Santé Lille 2, Lille, France 5Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Hasselt, Belgium.
[Ti] Título:A 5-Minute Interval between Two Dilating Eye Drops Increases Their Effect.
[So] Source:Optom Vis Sci;94(8):838-844, 2017 Aug.
[Is] ISSN:1538-9235
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Patients are usually advised to wait 5 minutes between eye drops. This delay supposedly allows the first drop not to be washed out by the second one, thereby increasing the combined effect. However, in the only experimental study conducted in humans on the concurrent administration of two different eye drops, the authors concluded that a 10-minute time interval between eye drops did not increase their combined effect. Our study was designed to address this puzzling observation. METHODS: Using digital photographs shot in photopic conditions in 40 eyes of 20 healthy volunteers, we compared relative pupil surface (i.e., pupil to iris surface area ratios) before and after the administration of one drop of 10% phenylephrine and one drop of 0.5% tropicamide either immediately or after a 5-minute time interval. RESULTS: Waiting 5 minutes yielded a 5.6% relative pupil surface gain (observer 1: P = .003, observer 2: P = .005) indicating an additional combined effect with a 5-minute time interval. CONCLUSIONS: These results show a detectable additive effect that is probably the result of methodological refinements including the challenging of the mydriasis by photopic conditions and the use of pupil and iris surface areas, which may show differences that would be undetectable in terms of diameter.
[Mh] Termos MeSH primário: Fenilefrina/administração & dosagem
Pupila/efeitos dos fármacos
Tropicamida/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Esquema de Medicação
Feminino
Seres Humanos
Iris/efeitos dos fármacos
Masculino
Meia-Idade
Midriáticos/administração & dosagem
Soluções Oftálmicas
Projetos Piloto
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); 0 (Ophthalmic Solutions); 1WS297W6MV (Phenylephrine); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1097/OPX.0000000000001104


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[PMID]:28658588
[Au] Autor:Banaee T; Ansari-Astaneh MR; Pourreza H; Faal Hosseini F; Vatanparast M; Shoeibi N; Jami V
[Ad] Endereço:a Retina Research Center, Khatam-al-Anbia Eye Hospital , Mashhad University of Medical Science , Mashhad , Iran.
[Ti] Título:Utility of 1% Tropicamide in Improving the Quality of Images for Tele-Screening of Diabetic Retinopathy in Patients with Dark Irides.
[So] Source:Ophthalmic Epidemiol;24(4):217-221, 2017 Aug.
[Is] ISSN:1744-5086
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the quality of fundus photographs taken before and after instillation of one drop of tropicamide. METHODS: The 45º fundus photographs were taken with a non-mydriatic fundus camera in three conditions of the pupil; pre-mydriatic, 10 minutes after one drop of tropicamide, and fully dilated. Two photographs were taken in each condition; one centered on the macula and the other on the optic disc. Two vitreoretinal specialists graded the images. RESULTS: A total of 1768 fundus photographs of 149 diabetic patients with dark irides were included. There were more ungradable images (38.1% and 50.3%, graders 1 and 2, respectively) in the non-mydriatic state than partially- (4.6% and 11.5%) or fully-dilated (15.4% and 10.0%) conditions (p < 0.001, both graders). Partially and fully dilated states had similar rates of ungradable images (p = 0.56 and p = 0.54, graders 1 and 2, respectively). Test-retest reliability (repeatability) was 92.5% and 74.3% for the two graders, respectively. Inter-grader agreement was moderate (Kappa = 0.50). CONCLUSION: Non-mydriatic fundus photographs have a high rate of ungradable images in patients with dark irides. Instillation of only one drop of tropicamide improves the quality of fundus photographs, which is not furthered by adding more drops. This strategy can be used in tele-ophthalmology programs.
[Mh] Termos MeSH primário: Retinopatia Diabética/diagnóstico
Iris/patologia
Programas de Rastreamento/métodos
Retina/patologia
Telemetria/métodos
Tropicamida/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Relação Dose-Resposta a Droga
Feminino
Angiofluoresceinografia
Fundo de Olho
Seres Humanos
Masculino
Midriáticos/administração & dosagem
Soluções Oftálmicas
Fotografia/métodos
Reprodutibilidade dos Testes
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); 0 (Ophthalmic Solutions); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1080/09286586.2016.1274039


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[PMID]:28426341
[Au] Autor:Pescina S; Macaluso C; Gioia GA; Padula C; Santi P; Nicoli S
[Ad] Endereço:a Food and Drug Department , University of Parma , Parma , Italy.
[Ti] Título:Mydriatics release from solid and semi-solid ophthalmic formulations using different in vitro methods.
[So] Source:Drug Dev Ind Pharm;43(9):1472-1479, 2017 Sep.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the present paper was the development of semi-solid (hydrogels) and solid (film) ophthalmic formulations for the controlled release of two mydriatics: phenylephrine and tropicamide. The formulations - based on polyvinylalcohol and hyaluronic acid - were characterized, and release studies were performed with three different in vitro set-ups, i.e. Franz-type diffusion cell, vial method and inclined plane; for comparison, a solution and a commercial insert, both clinically used to induce mydriasis, were evaluated. Both gels and film allowed for a controlled release of drugs, appearing a useful alternative for mydriatics administration. However, the release kinetic was significantly influenced by the method used, highlighting the need for optimization and standardization of in vitro models for the evaluation of drug release from ophthalmic dosage forms.
[Mh] Termos MeSH primário: Olho/efeitos dos fármacos
Midriáticos/farmacocinética
Soluções Oftálmicas/farmacologia
Fenilefrina/farmacocinética
Pupila/efeitos dos fármacos
Tropicamida/farmacocinética
[Mh] Termos MeSH secundário: Química Farmacêutica
Combinação de Medicamentos
Seres Humanos
Técnicas In Vitro
Midriáticos/administração & dosagem
Midriáticos/farmacologia
Soluções Oftálmicas/administração & dosagem
Soluções Oftálmicas/química
Fenilefrina/administração & dosagem
Fenilefrina/farmacologia
Tropicamida/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Mydriatics); 0 (Ophthalmic Solutions); 1WS297W6MV (Phenylephrine); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1318910


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[PMID]:28114580
[Au] Autor:Turnbull PR; Irani N; Lim N; Phillips JR
[Ad] Endereço:School of Optometry and Vision Science, The University of Auckland, Auckland, New Zealand.
[Ti] Título:Origins of Pupillary Hippus in the Autonomic Nervous System.
[So] Source:Invest Ophthalmol Vis Sci;58(1):197-203, 2017 Jan 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this study was to determine the relative roles of the sympathetic (SNS) and parasympathetic nervous system (PNS) in pupillary hippus. Methods: We used a paired-eye control study design with three cohorts receiving either 1.0% tropicamide (PNS antagonist) in light (TL), 1.0% tropicamide in dark (TD), or 10% phenylephrine (SNS) in light (PL), n = 12 in each. Each subject received one drop to the randomly determined treatment eye, while the other eye served as control. Bilateral measures of pupil size and dynamics were made over 2.6 seconds using an infrared eye-tracker sampling at 500 Hz. Measures were taken at baseline, then every 5 minutes for 40 minutes. Hippus, analyzed in both time and frequency domains, was compared between eyes and cohorts. Results: Pupillary hippus with a distinct dominant frequency was present in all measures at baseline (mean: 0.62 Hz, SD: 0.213 Hz), and that frequency did not change in any group (P = 0.971). Hippus magnitude (treatment eye relative to control eye) decreased in the TL (-72.8 ± 4.7%, P < 0.0001) and TD (-71.3 ± 2.6%, P < 0.0001) groups, but did not change in the PL (+5.4 ± 13.7%, P = 0.173) group, despite PL pupils dilating to a proportion similar to TD. Conclusions: Pupillary hippus can be extinguished by antagonizing the PNS, whereas agonizing the SNS dilates the pupil without affecting hippus. This suggests that hippus originates from central PNS activity, and not from SNS activity, or oscillations in the balance between PNS and SNS at the pupil.
[Mh] Termos MeSH primário: Adaptação Ocular/fisiologia
Sistema Nervoso Autônomo/fisiopatologia
Fenilefrina/farmacologia
Distúrbios Pupilares/etiologia
Pupila/fisiologia
Reflexo Pupilar/fisiologia
Tropicamida/farmacologia
[Mh] Termos MeSH secundário: Adulto
Sistema Nervoso Autônomo/efeitos dos fármacos
Feminino
Seres Humanos
Luz
Masculino
Midriáticos/farmacologia
Soluções Oftálmicas
Estimulação Luminosa
Distúrbios Pupilares/diagnóstico
Distúrbios Pupilares/fisiopatologia
Reflexo Pupilar/efeitos dos fármacos
Simpatomiméticos/farmacologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); 0 (Ophthalmic Solutions); 0 (Sympathomimetics); 1WS297W6MV (Phenylephrine); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20785


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[PMID]:27686663
[Au] Autor:Zeng Y; Gao JH
[Ad] Endereço:Department of Ophthalmology, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan, China.
[Ti] Título:Effects of Mydrin eye-drops on central corneal thickness values in adult patients with myopia.
[So] Source:Clin Exp Optom;100(2):151-154, 2017 Mar.
[Is] ISSN:1444-0938
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aimed to evaluate the effect of Mydrin eye-drops on central corneal thickness values and investigate the duration of the effect. METHODS: In this prospective randomised self-controlled study, we enrolled 60 myopic patients (120 eyes) undergoing corneal laser refractive surgery. The central corneal thickness was measured before and one and four hours after administration of Mydrin eye-drops (major components are tropicamide and phenylephrine hydrochloride) using the Orbscan II anterior segment analysis system and a SP-2000P non-contact specular microscope, respectively. RESULTS: Using the Orbscan II system, the baseline central corneal thickness (545 ± 27 µm) was significantly lower than that at one hour after Mydrin eye-drop application (559 ± 31 µm; p < 0.001); it was comparable to that at four hours post-Mydrin eye-drop administration (544 ± 26 µm; p < 0.74). Measured by non-contact specular microscopy, the baseline central corneal thickness (508 ± 26 µm) was significantly lower than that at one hour after Mydrin eye-drop application (521 ± 29 µm; p < 0.001); it was comparable to that at four hours after Mydrin eye-drop administration (506 ± 24 µm; p = 0.62). A significant difference was observed in the central corneal thickness at one and four hours after Mydrin eye-drop application by both methods (p < 0.001). Bland-Altman plots showed agreement between the measurements by the two methods at different times. CONCLUSION: Central corneal thickness increases one hour after topical application of Mydrin eye-drops and is normalised at four hours following the administration of the drops. For patients scheduled to undergo excimer laser corneal refractive surgery, the central corneal thickness should be measured before or four hours after administration of Mydrin eye-drops.
[Mh] Termos MeSH primário: Córnea/patologia
Miopia/cirurgia
Soluções Oftálmicas/administração & dosagem
Fenilefrina/administração & dosagem
Tropicamida/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Miopia/patologia
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Ophthalmic Solutions); 1WS297W6MV (Phenylephrine); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.1111/cxo.12465


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[PMID]:27519933
[Au] Autor:Lux AL; Degoumois A; Barjol A; Mouriaux F; Denion E
[Ad] Endereço:Medical School, Unicaen, PFRS, Caen Cedex, France.
[Ti] Título:Combination of 5% phenylephrine and 0.5% tropicamide eyedrops for pupil dilation in neonates is twice as effective as 0.5% tropicamide eyedrops alone.
[So] Source:Acta Ophthalmol;95(2):165-169, 2017 Mar.
[Is] ISSN:1755-3768
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Comparison of the efficacy of tropicamide eyedrops to the combination of 0.5% tropicamide and 5% phenylephrine eyedrops in order to achieve a proper dilation in premature infants undergoing screening for retinopathy of prematurity. METHODS: A prospective, randomized, double-blind study was conducted to compare the efficacy of two mydriatic regimens: one regimen consisting of three drops of 0.5% tropicamide (TTT regimen), the other regimen consisting of one drop of 5% phenylephrine and two drops of 0.5% tropicamide (PTT regimen). Thirty premature infants were enrolled and received both mydriatic regimens: one regimen in each eye. Outcomes were pupil dilation evaluated by the percentage of pupil diameter over cornea diameter, the percentage of pupil surface over cornea surface and the quality of the eye fundus examination. RESULTS: The percentage of pupil diameter over cornea diameter was 47.3% (±8.7) with the TTT regimen and 65.9% (±8.8) with the PTT regimen (p < 0.0001). The percentage of pupil surface over cornea surface was 23.1% (±8.3) with the TTT regimen and 43.8% (±7.3) with the PTT regimen (p < 0.0001). Thus, the pupil surface area was 1.9 times greater with the PTT than with the TTT regimen. Visualization of the retinal periphery was possible for 30 of 30 eyes dilated with the PTT regimen and for 16 of 30 eyes dilated with the TTT regimen (p < 0.0001). CONCLUSION: The dilated pupil surface area for the combination of 5% phenylephrine and 0.5% tropicamide was almost twice that for 0.5% tropicamide eyedrops alone and provided significantly superior quality of the eye fundus examination.
[Mh] Termos MeSH primário: Triagem Neonatal/métodos
Fenilefrina/administração & dosagem
Pupila/efeitos dos fármacos
Retinopatia da Prematuridade/diagnóstico
Tropicamida/administração & dosagem
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Método Duplo-Cego
Quimioterapia Combinada
Feminino
Seguimentos
Seres Humanos
Recém-Nascido
Masculino
Midriáticos/administração & dosagem
Soluções Oftálmicas
Oftalmoscopia
Estudos Prospectivos
Reprodutibilidade dos Testes
Retinopatia da Prematuridade/fisiopatologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); 0 (Ophthalmic Solutions); 1WS297W6MV (Phenylephrine); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170223
[Lr] Data última revisão:
170223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160814
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13175


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[PMID]:27321772
[Au] Autor:Bhurayanontachai P; Saengkaew S; Apiromruck P
[Ad] Endereço:Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand. Electronic address: patama103@yahoo.com.au.
[Ti] Título:Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative study.
[So] Source:J Optom;10(2):111-116, 2017 Apr - Jun.
[Is] ISSN:1989-1342
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Pupillary dilatation with three types of eye drops is used regularly in the clinic; however, a mixture of these drops in a single bottle may be more beneficial in reducing workloads and resources. This study compared the efficacy in pupillary dilatation between two protocols of dilating drop instillation. METHODS: This prospective, randomized, comparative study included 30 eligible Thai patients. The patients randomly received preoperative pupillary dilatations by either the conventional protocol (1% tropicamide (T), 10% phenylephrine (P) and 0.1% diclofenac (D) in three separate bottles) or the fixed combination (TPD) protocol which had the three types of eye drops mixed in a single bottle in a ratio of 4:3:3. The chi-square test and independent t-test were used to analyze the data. RESULTS: The conventional protocol group and TPD protocol group each had 15 patients. Sixty minutes after the initial instillation, all patients in the TPD protocol and 13 patients (86.7%) in conventional protocol achieved at least 6mm in the shortest diameter. The mydriatic rate between protocols showed no difference. In patients who received the TPD protocol, the systemic effects on the mean arterial blood pressure and pulse rate decreased over time. CONCLUSION: The mixture of tropicamide, phenylephrine and diclofenac had a comparable efficacy for a pupillary dilatation to the conventional dilating drops in separate bottles. The systemic complications on blood pressure and arterial pulse of the TPD mixture were less than the conventional protocol. TRIAL REGISTRATION: TCTR20130325001.
[Mh] Termos MeSH primário: Diclofenaco/farmacologia
Midriáticos/farmacologia
Soluções Oftálmicas/farmacologia
Fenilefrina/farmacologia
Pupila/efeitos dos fármacos
Tropicamida/farmacologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Pressão Sanguínea/efeitos dos fármacos
Diclofenaco/administração & dosagem
Combinação de Medicamentos
Quimioterapia Combinada
Feminino
Seres Humanos
Masculino
Meia-Idade
Midriáticos/administração & dosagem
Soluções Oftálmicas/administração & dosagem
Fenilefrina/administração & dosagem
Estudos Prospectivos
Tropicamida/administração & dosagem
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Mydriatics); 0 (Ophthalmic Solutions); 144O8QL0L1 (Diclofenac); 1WS297W6MV (Phenylephrine); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE



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