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  1 / 1937 MEDLINE  
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[PMID]:27467465
[Au] Autor:DeSalvo MN; Tanaka N; Douw L; Leveroni CL; Buchbinder BR; Greve DN; Stufflebeam SM
[Ad] Endereço:From the Athinoula A. Martinos Center for Biomedical Imaging, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (M.N.D., N.T., L.D., D.N.G., S.M.S.); and Departments of Neurology (C.L.L.) and Radiology (B.R.B., S.M.S.), Massachusetts General Hospital, Boston, Mass.
[Ti] Título:Resting-State Functional MR Imaging for Determining Language Laterality in Intractable Epilepsy.
[So] Source:Radiology;281(1):264-9, 2016 Oct.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To measure the accuracy of resting-state functional magnetic resonance (MR) imaging in determining hemispheric language dominance in patients with medically intractable focal epilepsies against the results of an intracarotid amobarbital procedure (IAP). Materials and Methods This study was approved by the institutional review board, and all subjects gave signed informed consent. Data in 23 patients with medically intractable focal epilepsy were retrospectively analyzed. All 23 patients were candidates for epilepsy surgery and underwent both IAP and resting-state functional MR imaging as part of presurgical evaluation. Language dominance was determined from functional MR imaging data by calculating a laterality index (LI) after using independent component analysis. The accuracy of this method was assessed against that of IAP by using a variety of thresholds. Sensitivity and specificity were calculated by using leave-one-out cross validation. Spatial maps of language components were qualitatively compared among each hemispheric language dominance group. Results Measurement of hemispheric language dominance with resting-state functional MR imaging was highly concordant with IAP results, with up to 96% (22 of 23) accuracy, 96% (22 of 23) sensitivity, and 96% (22 of 23) specificity. Composite language component maps in patients with typical language laterality consistently included classic language areas such as the inferior frontal gyrus, the posterior superior temporal gyrus, and the inferior parietal lobule, while those of patients with atypical language laterality also included non-classical language areas such as the superior and middle frontal gyri, the insula, and the occipital cortex. Conclusion Resting-state functional MR imaging can be used to measure language laterality in patients with medically intractable focal epilepsy. (©) RSNA, 2016 Online supplemental material is available for this article.
[Mh] Termos MeSH primário: Epilepsia Resistente a Medicamentos/diagnóstico por imagem
Epilepsia Resistente a Medicamentos/fisiopatologia
Lateralidade Funcional
Linguagem
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Amobarbital
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2016141010


  2 / 1937 MEDLINE  
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[PMID]:26188665
[Au] Autor:Chiu AH; Bynevelt M; Lawn N; Lee G; Singh TP
[Ad] Endereço:Neurological Intervention and Imaging Service of Western Australia, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia; Neurological Intervention and Imaging Service of Western Australia, Royal Perth Hospital, Perth, WA, Australia. Electronic address: albert.h.chiu@gmail.co
[Ti] Título:Propofol as a substitute for amobarbital in Wada testing.
[So] Source:J Clin Neurosci;22(11):1830-2, 2015 Nov.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:We describe a patient with equivocal findings on functional MRI (fMRI), who underwent a propofol Wada test, review the literature on this topic and suggest a protocol for the use of propofol for a Wada test. Although fMRI techniques can usually accurately lateralize language, the Wada test remains the gold standard for preoperative lateralization and is occasionally still required if there are non-diagnostic findings on fMRI. Amobarbital, the agent of choice for the Wada test, has become increasingly difficult to obtain and requires regulatory approval, which may delay definitive management and have an impact on patient outcomes. Propofol has been suggested as an alternative to amobarbital, and while there is some published data on this, there is no reported Australian experience to date.
[Mh] Termos MeSH primário: Craniotomia/métodos
Hipnóticos e Sedativos/uso terapêutico
Monitorização Neurofisiológica Intraoperatória/métodos
Testes de Linguagem
Propofol/uso terapêutico
[Mh] Termos MeSH secundário: Amobarbital/uso terapêutico
Austrália
Neoplasias Encefálicas/cirurgia
Eletroencefalografia/efeitos dos fármacos
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Neuronavegação/métodos
Vigília
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); GWH6IJ239E (Amobarbital); YI7VU623SF (Propofol)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151005
[Lr] Data última revisão:
151005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150720
[St] Status:MEDLINE


  3 / 1937 MEDLINE  
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[PMID]:26046456
[Au] Autor:Beimer NJ; Buchtel HA; Glynn SM
[Ad] Endereço:Department of Neurology, University of Michigan, Ann Arbor, Michigan, U.S.A.
[Ti] Título:One center's experience with complications during the Wada test.
[So] Source:Epilepsia;56(8):e110-3, 2015 Aug.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to define the number and type of complications associated with the Wada test at an academic medical center for comparison to previous reports. We performed a retrospective review of medical records for patients who underwent the Wada test at the University of Michigan between April 1991 and June 2013. Information was collected regarding the angiography procedure and the immediate postoperative period to assess for both clinical and angiographic complications. A total of 436 patients were identified who underwent the Wada procedure between April 1991 and June 2013, and 431 patients were included in the final analysis. Twenty-five patients (5.8%) had notable clinical events associated with the Wada test. Nine patients (2.1%) had clinical events meeting criteria for complication, which included seizures, status epilepticus, internal carotid artery vasospasm, inadvertent injection of anesthetic in the external carotid artery, and transient encephalopathy. No complications were associated with significant morbidity or mortality. This retrospective review of patients undergoing the Wada test found significantly fewer associated complications in comparison to previously published studies, with no patients experiencing long-term morbidity. The Wada test should be considered a safe diagnostic tool for lateralizing language and memory.
[Mh] Termos MeSH primário: Amobarbital
Anestésicos Intravenosos
Artéria Carótida Interna
Técnicas de Diagnóstico Neurológico/efeitos adversos
Epilepsia/diagnóstico
Lateralidade Funcional
Hipnóticos e Sedativos
Metoexital
Convulsões/etiologia
[Mh] Termos MeSH secundário: Estudos de Coortes
Epilepsia/cirurgia
Hematoma/etiologia
Seres Humanos
Injeções Intra-Arteriais
Cuidados Pré-Operatórios
Estudos Retrospectivos
Espasmo/etiologia
Estado Epiléptico/etiologia
Vasoconstrição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (Hypnotics and Sedatives); E5B8ND5IPE (Methohexital); GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150606
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13046


  4 / 1937 MEDLINE  
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[PMID]:25765692
[Au] Autor:Helmstaedter C; Jockwitz C; Witt JA
[Ad] Endereço:Department of Epileptology, University of Bonn, Bonn, Germany. Electronic address: C.Helmstaedter@uni-bonn.de.
[Ti] Título:Menstrual cycle corrupts reliable and valid assessment of language dominance: Consequences for presurgical evaluation of patients with epilepsy.
[So] Source:Seizure;28:26-31, 2015 May.
[Is] ISSN:1532-2688
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Functional transcranial Doppler sonography (fTCD) is a valid and non-invasive tool for determining language dominance, e.g. in the context of presurgical evaluations. Beyond this, fTCD might be an ideal tool to study dynamics in language dominance over time. However, an essential prerequisite would be a high test-retest reliability. This was addressed in the present study. METHODS: Test-retest reliability of hemispheric hemodynamics during open speech was determined in 11 male and 11 female healthy volunteers using the Animation Description Paradigm. Expressive language dominance was assessed weekly over an interval of 4-5 weeks. RESULTS: Internal consistency of the four measurements was excellent (split-half reliability 0.85-0.95), but test-retest reliability of the lateralization index was poor to moderate (rtt=0.37-0.74). Controlling for gender, test-retest reliabilities were better in men (rtt=0.67-0.78) as compared to women (rtt=0.04-0.70). When arranging the assessments in women around day one of menstruation - all were on contraceptives - a significant shift from left hemisphere dominance toward bilaterality (t=2.2 p=0.04) was evident around menstruation with significant reversal afterwards (t=-3.4 p=0.005). CONCLUSION: A high intraindividual variability of language dominance patterns is indicated in women when assessed repeatedly by fTCD. Menstrual cycle appeared to be the source of inconsistency. The finding challenges the use of non-deactivating methods for language dominance assessment in epilepsy. Support for this is demonstrated with a female patient with epilepsy in whom language dominance assessed by repeated fMRI and fTCD varied concordantly with cycle but not so the repeated intracarotidal amobarbital test.
[Mh] Termos MeSH primário: Amobarbital
Epilepsia
Lateralidade Funcional/fisiologia
Hipnóticos e Sedativos
Linguagem
Ciclo Menstrual
[Mh] Termos MeSH secundário: Adulto
Amobarbital/administração & dosagem
Análise de Variância
Encéfalo/irrigação sanguínea
Encéfalo/efeitos dos fármacos
Encéfalo/fisiopatologia
Epilepsia/diagnóstico por imagem
Epilepsia/fisiopatologia
Epilepsia/cirurgia
Feminino
Seres Humanos
Hipnóticos e Sedativos/administração & dosagem
Processamento de Imagem Assistida por Computador
Injeções Intra-Arteriais
Imagem por Ressonância Magnética
Masculino
Ciclo Menstrual/efeitos dos fármacos
Ciclo Menstrual/fisiologia
Meia-Idade
Oxigênio/sangue
Reprodutibilidade dos Testes
Fatores Sexuais
Ultrassonografia Doppler Transcraniana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); GWH6IJ239E (Amobarbital); S88TT14065 (Oxygen)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150314
[St] Status:MEDLINE


  5 / 1937 MEDLINE  
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[PMID]:25725292
[Au] Autor:Babu D; Leclercq G; Goossens V; Vanden Berghe T; Van Hamme E; Vandenabeele P; Lefebvre RA
[Ad] Endereço:Heymans Institute of Pharmacology, Faculty of Medicine and Health Sciences, Ghent University, Belgium. Electronic address: dinesh.babu@ugent.be.
[Ti] Título:Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells.
[So] Source:Cell Signal;27(6):1141-58, 2015 Jun.
[Is] ISSN:1873-3913
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:TNF-α/cycloheximide (CHX)-induced apoptosis of the mouse intestinal epithelial cell line MODE-K corresponds with the production of reactive oxygen species (ROS). The aim of the study is to investigate the sources of ROS production contributing to apoptotic cell death during TNF-α/CHX-induced oxidative stress in MODE-K cells. Total ROS or mitochondrial superoxide anion production was measured simultaneously with cell death in the absence or presence of pharmacological inhibitors of various ROS-producing systems, and of ROS scavengers/antioxidants. The influence of TNF-α/CHX on mitochondrial membrane potential (Ψ(m)) and cellular oxygen consumption was also studied. TNF-α/CHX time-dependently increased intracellular total ROS and mitochondrial superoxide anion production in MODE-K cells, starting from 2h. Inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) by a pan-NOX inhibitor (VAS-2870) and a specific inhibitor of Rac1 (NSC23766) significantly reduced TNF-α/CHX-induced total ROS and cell death levels. The mitochondrial electron transport chain inhibitors, amytal (IQ site of complex I) and TTFA (Qp site of complex II) showed a pronounced decrease in TNF-α/CHX-induced total ROS, mitochondrial superoxide anion and cell death levels. TNF-α/CHX treatment caused an immediate decrease in mitochondrial respiration, and a loss of Ψ(m) and increase in mitochondrial dysfunction from 1 h on. The results suggest that mitochondria and NOX are the two major sources of ROS overproduction during TNF-α/CHX-induced cell death in MODE-K cells, with superoxide anions being the major ROS species. Particularly, the quinone-binding sites of mitochondrial complex I (site I(Q)) and complex II (site Qp) seem to be the major sites of mitochondrial ROS production.
[Mh] Termos MeSH primário: Cicloeximida/farmacologia
Mitocôndrias/metabolismo
NADPH Oxidases/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Fator de Necrose Tumoral alfa/farmacologia
[Mh] Termos MeSH secundário: Acetona/análogos & derivados
Acetona/farmacologia
Amobarbital/farmacologia
Animais
Apoptose/efeitos dos fármacos
Linhagem Celular
Complexo I de Transporte de Elétrons/antagonistas & inibidores
Complexo I de Transporte de Elétrons/metabolismo
Complexo II de Transporte de Elétrons/antagonistas & inibidores
Complexo II de Transporte de Elétrons/metabolismo
Células Epiteliais/metabolismo
Intestinos/citologia
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Camundongos
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/genética
Proteínas Recombinantes/farmacologia
Superóxidos/metabolismo
Tiofenos/farmacologia
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Recombinant Proteins); 0 (Thiophenes); 0 (Tumor Necrosis Factor-alpha); 0 (theonyltrifluoroacetone); 11062-77-4 (Superoxides); 1364PS73AF (Acetone); 98600C0908 (Cycloheximide); EC 1.3.5.1 (Electron Transport Complex II); EC 1.6.3.- (NADPH Oxidases); EC 1.6.5.3 (Electron Transport Complex I); GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150301
[St] Status:MEDLINE


  6 / 1937 MEDLINE  
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[PMID]:25647093
[Au] Autor:Bharadwaj S; Venkatraghavan L
[Ad] Endereço:Department of Anesthesia, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
[Ti] Título:Dexmedetomidine Sedation for WADA Test With Intracarotid Propofol in Pediatric Patients.
[So] Source:J Neurosurg Anesthesiol;27(4):352-3, 2015 Oct.
[Is] ISSN:1537-1921
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Amobarbital
Anestésicos Intravenosos
Dexmedetomidina
Hipnóticos e Sedativos
Propofol
[Mh] Termos MeSH secundário: Artérias Carótidas
Cateterismo
Criança
Sedação Consciente
Eletroencefalografia/efeitos dos fármacos
Feminino
Artéria Femoral
Lateralidade Funcional
Seres Humanos
Linguagem
Masculino
Memória/efeitos dos fármacos
Vigília
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (Hypnotics and Sedatives); 67VB76HONO (Dexmedetomidine); GWH6IJ239E (Amobarbital); YI7VU623SF (Propofol)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150904
[Lr] Data última revisão:
150904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150204
[St] Status:MEDLINE
[do] DOI:10.1097/ANA.0000000000000165


  7 / 1937 MEDLINE  
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[PMID]:25561380
[Au] Autor:Akman CI; Micic V; Quach M; Wilfong AA; Schultz R; Riviello JJ; Chapieski ML
[Ad] Endereço:Division of Pediatric Neurology, Texas Children's Hospital, Houston, TX, USA; Division of Pediatric Neurology, Clinical Neurophysiology, Texas Children's Hospital, Houston, TX, USA. Electronic address: cia11@columbia.edu.
[Ti] Título:Application of envelope trend to analyze early EEG changes in the frontal regions during intracarotid amobarbital procedure in children.
[So] Source:Epilepsy Behav;43:66-73, 2015 Feb.
[Is] ISSN:1525-5069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Intracarotid amobarbital procedure (IAP) is acknowledged as the gold standard test for language lateralization. EEG is performed routinely during IAP to monitor the anesthetization of a brain hemisphere. Here, we studied the correlation between the early EEG changes using envelope trend and the clinical outcome of IAP. METHOD: Fifty consecutive patients underwent IAP at Texas Children's Hospital (2004-2009). Intracarotid amobarbital procedure was considered "complete" or "incomplete" based on the outcome if the procedure was completed or aborted due to behavior changes. Envelope trend was used to calculate the median EEG amplitude changes within the first 60s of IAP. Statistical analysis was performed to determine the role of EEG changes and clinical features on the procedure outcome. RESULTS: Only 30 IAP-EEG files were available for review. Amobarbital was administered at the dose of 60-150mg (mean: 110±20). The intracarotid amobarbital procedure was recorded as complete in 23 patients and incomplete in 7 patients. EEG changes occurred within the first few seconds following amobarbital injection. Following amobarbital injection, focal slowing was present in the ipsilateral frontal region or both ipsilateral and contralateral frontal regions. Elapsed time to the first EEG change or duration and change in median EEG amplitude in the ipsilateral frontal regions were indifferent between the complete and incomplete groups (p>0.05). However, the median amplitude changes between the ipsilateral and contralateral frontal regions within each group were found significant only in the complete group (p<0.05), suggesting ipsilateral without contralateral frontal slowing. Other than age at the time of IAP (p=0.03), none of the other clinical features correlated with the clinical outcome of IAP (p>0.05). CONCLUSION: Early EEG changes during IAP using envelope trend may predict successful completion of the IAP test. Younger children are at risk of behavioral changes during IAP.
[Mh] Termos MeSH primário: Amobarbital
Eletroencefalografia/efeitos dos fármacos
Epilepsia/diagnóstico
Epilepsia/psicologia
Lobo Frontal/efeitos dos fármacos
Hipnóticos e Sedativos
[Mh] Termos MeSH secundário: Adolescente
Amobarbital/administração & dosagem
Artérias Carótidas
Criança
Pré-Escolar
Relação Dose-Resposta a Droga
Feminino
Lateralidade Funcional
Seres Humanos
Hipnóticos e Sedativos/administração & dosagem
Infusões Intra-Arteriais
Linguagem
Masculino
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150107
[St] Status:MEDLINE


  8 / 1937 MEDLINE  
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[PMID]:25436907
[Au] Autor:Yang M; Stowe DF; Udoh KB; Heisner JS; Camara AK
[Ad] Endereço:Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United States of America.
[Ti] Título:Reversible blockade of complex I or inhibition of PKCß reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia.
[So] Source:PLoS One;9(12):e113534, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reperfusion (IR) injury. P66Shc, a splice variant of the ShcA adaptor protein family, enhances mROS production by oxidizing reduced cytochrome c to yield H2O2. Ablation of p66Shc protects against IR injury, but it is unknown if and when p66Shc is activated during cardiac ischemia and/or reperfusion and if attenuating complex I electron transfer or deactivating PKCß alters p66Shc activation during IR is associated with cardioprotection. METHODS: Isolated guinea pig hearts were perfused and subjected to increasing periods of ischemia and reperfusion with or without amobarbital, a complex I blocker, or hispidin, a PKCß inhibitor. Phosphorylation of p66Shc at serine 36 and levels of p66Shc in mitochondria and cytosol were measured. Cardiac functional variables and redox states were monitored online before, during and after ischemia. Infarct size was assessed in some hearts after 120 min reperfusion. RESULTS: Phosphorylation of p66Shc and its translocation into mitochondria increased during reperfusion after 20 and 30 min ischemia, but not during ischemia only, or during 5 or 10 min ischemia followed by 20 min reperfusion. Correspondingly, cytosolic p66Shc levels decreased during these ischemia and reperfusion periods. Amobarbital or hispidin reduced phosphorylation of p66Shc and its mitochondrial translocation induced by 30 min ischemia and 20 min reperfusion. Decreased phosphorylation of p66Shc by amobarbital or hispidin led to better functional recovery and less infarction during reperfusion. CONCLUSION: Our results show that IR activates p66Shc and that reversible blockade of electron transfer from complex I, or inhibition of PKCß activation, decreases p66Shc activation and translocation and reduces IR damage. These observations support a novel potential therapeutic intervention against cardiac IR injury.
[Mh] Termos MeSH primário: Complexo I de Transporte de Elétrons/antagonistas & inibidores
Coração/fisiopatologia
Mitocôndrias/metabolismo
Proteína Quinase C beta/antagonistas & inibidores
Inibidores de Proteínas Quinases/farmacologia
Traumatismo por Reperfusão/fisiopatologia
Proteínas Adaptadoras da Sinalização Shc/metabolismo
[Mh] Termos MeSH secundário: Amobarbital/farmacologia
Animais
Transporte de Elétrons/efeitos dos fármacos
Ativação Enzimática/efeitos dos fármacos
Cobaias
Coração/efeitos dos fármacos
Mitocôndrias/efeitos dos fármacos
Isquemia Miocárdica/metabolismo
Isquemia Miocárdica/patologia
Isquemia Miocárdica/fisiopatologia
Proteína Quinase C beta/metabolismo
Transporte Proteico/efeitos dos fármacos
Traumatismo por Reperfusão/metabolismo
Traumatismo por Reperfusão/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors); 0 (Shc Signaling Adaptor Proteins); EC 1.6.5.3 (Electron Transport Complex I); EC 2.7.11.13 (Protein Kinase C beta); GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141202
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0113534


  9 / 1937 MEDLINE  
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[PMID]:25358753
[Au] Autor:Loring D
[Ad] Endereço:Emory University.
[Ti] Título:Commentary: Epilepsia's Wada survey.
[So] Source:Epilepsia;55(12):1891, 2014 Dec.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Amobarbital
Mapeamento Encefálico
Córtex Cerebral/fisiopatologia
Epilepsia/patologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Nm] Nome de substância:
GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141101
[St] Status:MEDLINE
[do] DOI:10.1111/epi.12836


  10 / 1937 MEDLINE  
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[PMID]:25358674
[Au] Autor:Papanicolaou AC
[Ad] Endereço:Division of Clinical Neurosciences, University of Tennessee Health Science Center-Memphis; Le Bonheur Neuroscience Institute.
[Ti] Título:Commentary: Epilepsia's Wada survey.
[So] Source:Epilepsia;55(12):1890, 2014 Dec.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Amobarbital
Mapeamento Encefálico
Córtex Cerebral/fisiopatologia
Epilepsia/patologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Nm] Nome de substância:
GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141101
[St] Status:MEDLINE
[do] DOI:10.1111/epi.12835



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