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Pesquisa : D03.383.742.698.253.150 [Categoria DeCS]
Referências encontradas : 469 [refinar]
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[PMID]:26253375
[Au] Autor:Fujinuma K; Ishii Y; Yashihashi Y; Yonemochi E; Sugano K; Tarada K
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan; Generic Pharmaceutical Development Department, Nippon Chemiphar Co., Ltd., 1-22, Hikokawado, Misato, Saitama 341-0005, Japan.
[Ti] Título:Triboelectrification of active pharmaceutical ingredients: week acids and their salts.
[So] Source:Int J Pharm;493(1-2):434-8, 2015 Sep 30.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The effect of salt formulation on the electrostatic property of active pharmaceutical ingredients was investigated. The electrostatic property of weak acids (carboxylic acids and amide-enole type acid) and their sodium salts was evaluated by a suction-type Faraday cage meter. Free carboxylic acids showed negative chargeability, whereas their sodium salts showed more positive chargeability than the free acids. However, no such trend was observed for amide-enole type acids.
[Mh] Termos MeSH primário: Ácidos Carboxílicos/química
[Mh] Termos MeSH secundário: Barbital/química
Química Farmacêutica
Dantroleno/química
Omeprazol/química
Sais/química
Eletricidade Estática
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Salts); 5WZ53ENE2P (Barbital); F64QU97QCR (Dantrolene); KG60484QX9 (Omeprazole)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150831
[Lr] Data última revisão:
150831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150809
[St] Status:MEDLINE


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[PMID]:25080369
[Au] Autor:Zulkefeli M; Hisamatsu Y; Suzuki A; Miyazawa Y; Shiro M; Aoki S
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510 (Japan), Fax: (+81) 4-7121-3670; Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor 42300 (Malaysia).
[Ti] Título:Supramolecular phosphatases formed by the self-assembly of the bis(Zn²âº-cyclen) complex, copper(II), and barbital derivatives in water.
[So] Source:Chem Asian J;9(10):2831-41, 2014 Oct.
[Is] ISSN:1861-471X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In our previous paper, we reported that a dimeric Zn(2+) complex with a 2,2'-bipyridyl linker (Zn2L(1)), cyanuric acid (CA), and a Cu(2+) ion automatically assemble in aqueous solution to form 4:4:4 complex 3, which selectively catalyzes the hydrolysis of mono(4-nitrophenyl)phosphate (MNP) at neutral pH. Herein, we report that the use of barbital (Bar) instead of CA for the self-assembly with Zn2L(1) and Cu(2+) induces 2:2:2 complexation of these components, and not the 4:4:4 complex, to form supramolecular complex 6 a, the structure and equilibrium characteristics of which were studied by analytical and physical measurements. The finding show that 6 a also accelerates the hydrolysis of MNP, similarly to 3. Moreover, inspired by the crystal structure of 6 a, we prepared barbital units that contain functional groups on their side chains in an attempt to produce supramolecular phosphatases that possess functional groups near the Cu2(µ-OH)2 catalytic core so as to mimic the catalytic center of alkaline phosphatase (AP).
[Mh] Termos MeSH primário: Barbital/química
Cobre/química
Compostos Heterocíclicos/química
Zinco/química
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Espectrofotometria Ultravioleta
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Heterocyclic Compounds); 059QF0KO0R (Water); 5WZ53ENE2P (Barbital); 789U1901C5 (Copper); 964584YO2O (cyclen); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140801
[St] Status:MEDLINE
[do] DOI:10.1002/asia.201402513


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[PMID]:24283960
[Au] Autor:Zencirci N; Griesser UJ; Gelbrich T; Apperley DC; Harris RK
[Ad] Endereço:Institute of Pharmacy, University of Innsbruck , Innrain 52, 6020 Innsbruck, Austria.
[Ti] Título:Crystal polymorphs of barbital: news about a classic polymorphic system.
[So] Source:Mol Pharm;11(1):338-50, 2014 Jan 06.
[Is] ISSN:1543-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Barbital is a hypnotic agent that has been intensely studied for many decades. The aim of this work was to establish a clear and comprehensible picture of its polymorphic system. Four of the six known solid forms of barbital (denoted I(0), III, IV, and V) were characterized by various analytical techniques, and the thermodynamic relationships between the polymorph phases were established. The obtained data permitted the construction of the first semischematic energy/temperature diagram for the barbital system. The modifications I(0), III, and V are enantiotropically related to one another. Polymorph IV is enantiotropically related to V and monotropically related to the other two forms. The transition points for the pairs I(0)/III, I(0)/V, and III/IV lie below 20 °C, and the transition point for IV/V is above 20 °C. At room temperature, the order of thermodynamic stability is I(0) > III > V > IV. The metastable modification III is present in commercial samples and has a high kinetic stability. The solid-state NMR spectra provide information on aspects of crystallography (viz., the asymmetric units and the nature of hydrogen bonding). The known correlation between specific N-H···O═C hydrogen bonding motifs of barbiturates and certain IR characteristics was used to predict the H-bonded pattern of polymorph IV.
[Mh] Termos MeSH primário: Barbital/química
Cristalização
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Cristalografia por Raios X
Ligações de Hidrogênio
Espectroscopia de Ressonância Magnética
Solubilidade
Espectroscopia de Infravermelho com Transformada de Fourier
Análise Espectral Raman
Termodinâmica
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
5WZ53ENE2P (Barbital)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131129
[St] Status:MEDLINE
[do] DOI:10.1021/mp400515f


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[PMID]:24620500
[Au] Autor:Peplow T
[Ti] Título:A history of the barbiturates: the lure, the controversy, the poison.
[So] Source:Pharm Hist (Lond);43(3):59-66, 2013 Sep.
[Is] ISSN:0079-1393
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Barbitúricos/história
[Mh] Termos MeSH secundário: Barbital/efeitos adversos
Barbital/história
Barbital/envenenamento
Barbital/uso terapêutico
Barbitúricos/efeitos adversos
Barbitúricos/envenenamento
Barbitúricos/uso terapêutico
Prescrições de Medicamentos/história
História do Século XX
Seres Humanos
Hipnóticos e Sedativos/efeitos adversos
Hipnóticos e Sedativos/história
Hipnóticos e Sedativos/envenenamento
Hipnóticos e Sedativos/uso terapêutico
Reino Unido
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Barbiturates); 0 (Hypnotics and Sedatives); 5WZ53ENE2P (Barbital)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:140314
[St] Status:MEDLINE


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[PMID]:23220533
[Au] Autor:Masoud MS; Abd El-Kaway MY
[Ad] Endereço:Chemistry Department, Faculty of Science, Alexandria University, Ibrahimia, P.O. Box 426, Alexandria 21321, Egypt. drmsmasoud@yahoo.com
[Ti] Título:Infrared and electron spin resonance spectral studies of some copper purine and pyrimidine complexes.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;102:175-85, 2013 Feb.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Copper guanine and barbital complexes were prepared and characterized by elemental analyses and spectral measurements. The data typified the formation of stoichiometries 1:1 (M:L) with possible Cu-Cu interaction "association". The complexes are with different geometries: square planar, square pyramidal and tetrahedral. The mode of bonding was identified by IR spectra. EPR spectra of the powdered complexes were recorded at X band at the room temperature. Different ESR parameters were calculated and discussed: g(//), g(⊥), A(//), [g], G, F, K, α(2). Molecular modeling techniques and quantum chemical methods have been performed for copper complexes to correlate the chemical structures of the complexes with their physical molecular properties. Bond lengths, bond orders, bond angles, dihedral angles, close contact, dipole moment (µ), sum of the total negative charge (STNC), electronegativity (χ), chemical potential (Pi), global hardness (η), softness (σ), the highest occupied molecular orbital energy (E(HOMO)), the lowest unoccupied molecular orbital energy (E(LUMO)) and the energy gap (ΔE) were calculated using PM3 semi-empirical and Molecular Mechanics (MM+) methods. The study displays a good correlation between the theoretical and experimental data which confirms the reliability of the quantum chemical methods.
[Mh] Termos MeSH primário: Barbital/química
Complexos de Coordenação/química
Cobre/química
Guanina/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância de Spin Eletrônica
Modelos Moleculares
Teoria Quântica
Espectrofotometria Infravermelho
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 5WZ53ENE2P (Barbital); 5Z93L87A1R (Guanine); 789U1901C5 (Copper)
[Em] Mês de entrada:1306
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121211
[St] Status:MEDLINE


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[PMID]:22393695
[Au] Autor:Chang Q; Ma H; Wang F; Ou H; Zou M
[Ad] Endereço:Xiangya Hospital, Central South University, Changsha 410008, China.
[Ti] Título:[Determination of 10 sedative-hypnotics in human plasma using pulse splitless injection technique and gas chromatography-mass spectrometry].
[So] Source:Se Pu;29(11):1082-6, 2011 Nov.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A simple, precise and sensitive gas chromatography-mass spectrometry (GC-MS) method coupled with pulse splitless injection technique was developed for the determination of 10 sedative-hypnotics (barbital, amobarbital, phenobarbital, oxazepam, diazepam, nitrazepam, clonazepam, estazolam, alprazolam, triazolam) in human plasma. The drugs spiked in plasma were extracted with ethyl acetate after alkalization with 0.1 mol/L NaOH solution. The organic solvent was evaporated under nitrogen stream, and the residues were redissolved by ethyl acetate. The separation was performed on an HP-5MS column (30 m x 250 microm x 0.25 microm). The analytes were determined and identified using selected ion monitoring (SIM) mode and scan mode, respectively. The internal standard method was used for the determination. The target analytes were well separated from each other on their SIM chromatograms and also on the total ion current (TIC) chromatograms. The blank extract from human plasma gave no peaks that interfered with all the analytes on the chromatogram. The calibration curves for 10 sedative-hypnotics showed excellent linearity. The correlation coefficients of all the drugs were higher than 0.9954. The recoveries of the drugs spiked in human plasma ranged from 92.28% to 111.7%, and the relative standard deviations (RSDs) of intra-day and inter-day determinations were from 4.09% to 14.26%. The detection limits ranged from 2 to 20 microg/L. The method is simple, reliable, rapid and sensitive for the determination and the quantification of 10 sedative-hypnotics in human plasma and seems to be useful in the practice of clinical toxicological cases.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas/métodos
Hipnóticos e Sedativos/sangue
[Mh] Termos MeSH secundário: Barbital/sangue
Estazolam/sangue
Seres Humanos
Oxazepam/sangue
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); 36S3EQV54C (Estazolam); 5WZ53ENE2P (Barbital); 6GOW6DWN2A (Oxazepam)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120308
[St] Status:MEDLINE


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[PMID]:22069599
[Au] Autor:Mantle PG; Dobrota M; Gillett CE; Odell EW; Pinder SE
[Ad] Endereço:Centre for Environmental Policy, Imperial College London, London, UK. p.mantle@imperial.ac.uk
[Ti] Título:Oncological outcomes in rats given nephrocarcinogenic exposure to dietary ochratoxin a, followed by the tumour promoter sodium barbital for life: a pilot study.
[So] Source:Toxins (Basel);2(4):552-71, 2010 04.
[Is] ISSN:2072-6651
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The potent experimental renal carcinogenesis of ochratoxin A (OTA) in male rats makes the dietary contaminant a potential factor in human oncology. We explored whether the tumour promoter sodium barbitate could shorten the otherwise long latency between exposure to toxin and tumourigenesis. Young rats, of a hybrid in which mononuclear leukaemia was rare, were given feed contaminated (5 ppm) with OTA for 36 weeks to initiate renal tumourigenesis. Some individuals were thereafter given sodium barbitate (500 ppm in drinking water) for life. Pathological outcomes were studied at or near the end of natural life. Renal tumours in males given barbitate became evident after latency of one year, but only slightly before those without barbitate. In contrast, female mammary tumourigenesis was advanced by at least 6 months synchronously in all rats given the OTA-barbitate regimen compared to tumourigenesis in controls. Diagnosis of malignant mammary angiosarcoma in a female given the OTA-barbitate regimen is a new finding in the rat. The long latency of OTA-induced renal tumourigenesis was not notably susceptible to accelerated promotion by barbitate, contrasting with an apparently marked effect of barbitate on development of mammary tumours.
[Mh] Termos MeSH primário: Barbital/toxicidade
Neoplasias Renais/induzido quimicamente
Neoplasias Mamárias Experimentais/induzido quimicamente
Micotoxinas/toxicidade
Ocratoxinas/toxicidade
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Ocratoxinas/sangue
Projetos Piloto
Ratos
Ratos Endogâmicos F344
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Mycotoxins); 0 (Ochratoxins); 1779SX6LUY (ochratoxin A); 5WZ53ENE2P (Barbital)
[Em] Mês de entrada:1208
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111110
[St] Status:MEDLINE
[do] DOI:10.3390/toxins2040552


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[PMID]:20951851
[Au] Autor:Sheng J; Lei J; Ju H; Song C; Zhang D
[Ad] Endereço:Key Laboratory of Analytical Chemistry for Life Science (Ministry of Education of China), Department of Chemistry, Nanjing University, Nanjing 210093, PR China.
[Ti] Título:Rapid ultraviolet monitoring of multiple psychotropic drugs with a renewable microfluidic device.
[So] Source:Anal Chim Acta;679(1-2):1-6, 2010 Oct 29.
[Is] ISSN:1873-4324
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A rapid method for sensitive ultraviolet detection of multiple psychotropic drugs in human plasma was developed on a low-cost and expediently fabricated hybrid microfluidic device. The device was composed of one fused-silica capillary with a sampling fracture, a poly(methyl methacrylate) board with four reservoirs, and a printed circuit board. At the optimal separation and detection conditions, the baseline separation of three kinds of psychotropic drugs including barbiturates (phenobarbital and barbital), benzodiazepines (nitrazepam, clonazepam, chlordiazepoxide, alprazolam and diazepam) and tricyclic antidepressant drugs (amitriptyline) was achieved within 200 s with separation efficiency up to 3.80 × 10(5) plates m(-1). The linear ranges for ultraviolet detection were from 2.0 to 1000.0 µg mL(-1) for chlordiazepoxide and 1.0 to 1000.0 µg mL(-1) for other seven drugs. Combining with solid-phase extraction, this novel protocol could successfully be used to screen naturally existing psychotropic drugs in a known human plasma sample. The minimum detectable concentration was down to 27 ng mL(-1) for phenobarbital spiked in plasma. This work provided a promising way to initially screen different psychotropic drugs with high resolution, rapid separation and low-cost.
[Mh] Termos MeSH primário: Eletroforese em Microchip/instrumentação
Eletroforese em Microchip/métodos
Técnicas Analíticas Microfluídicas/instrumentação
Psicotrópicos/sangue
[Mh] Termos MeSH secundário: Amitriptilina/sangue
Barbital/sangue
Benzodiazepinas/sangue
Equipamentos Descartáveis
Desenho de Equipamento
Feminino
Seres Humanos
Limite de Detecção
Masculino
Fenobarbital/sangue
Fotometria
Reprodutibilidade dos Testes
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Psychotropic Drugs); 12794-10-4 (Benzodiazepines); 1806D8D52K (Amitriptyline); 5WZ53ENE2P (Barbital); YQE403BP4D (Phenobarbital)
[Em] Mês de entrada:1104
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101019
[St] Status:MEDLINE
[do] DOI:10.1016/j.aca.2010.08.019


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[PMID]:20681553
[Au] Autor:Dávalos JZ; Ribeiro da Silva Md; Ribeiro da Silva MA; Freitas VL; Jiménez P; Roux MV; Cabildo P; Claramunt RM; Elguero J
[Ad] Endereço:Instituto de Química Física Rocasolano, CSIC, Serrano, 119, E-28006 Madrid, Spain. jdavalos@iqfr.csic.es
[Ti] Título:Computational thermochemistry of six ureas, imidazolidin-2-one, N,N'-trimethyleneurea, benzimidazolinone, parabanic acid, barbital (5,5'-diethylbarbituric acid), and 3,4,4'-trichlorocarbanilide, with an extension to related compounds.
[So] Source:J Phys Chem A;114(34):9237-45, 2010 Sep 02.
[Is] ISSN:1520-5215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A computational study of the structural and thermochemical properties of N-phenyl (open) and N-alkyl (cyclic) ureas, through the use of M05-2X and B3LYP density functional theory calculations has been carried out. The consistency of the literature experimental results has been confirmed, and using mainly isodesmic reactions, the unknown Delta(f)H(0)(g) of the other urea derivatives were estimated. The experimental results together with the theoretical information have permitted the study of the effect of phenyl, p- and m-chlorophenyl, alkyl, and carbonyl substitutions on the thermodynamical stability of urea and its cyclic derivatives. The peculiar behavior of the N-tert-butyl substituent in cyclic ureas has been related to geometric deformations.
[Mh] Termos MeSH primário: Barbital/química
Carbanilidas/química
Hidantoínas/química
Imidazolidinas/química
Compostos de Metilureia/química
Teoria Quântica
Temperatura Ambiente
Ureia/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Conformação Molecular
Compostos de Fenilureia/química
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carbanilides); 0 (Hydantoins); 0 (Imidazolidines); 0 (Methylurea Compounds); 0 (Phenylurea Compounds); 2K48456N55 (ethylene urea); 3XGR439T9P (parabanic acid); 5WZ53ENE2P (Barbital); 632-14-4 (N,N',N'-trimethylurea); 8W8T17847W (Urea); BGG1Y1ED0Y (triclocarban)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100805
[St] Status:MEDLINE
[do] DOI:10.1021/jp103514f


  10 / 469 MEDLINE  
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[PMID]:20458916
[Au] Autor:Zhang X; Cai X; Zhang X
[Ad] Endereço:Wenzhou Center for Disease Control and Prevention, Wenzhou 325001, China. xyzwz123@126.com
[Ti] Título:[Rapid simultaneous determination of 42 psychoactive drugs and their metabolites in human plasma and urine by ultra performance liquid chromatography-tandem mass spectrometry].
[So] Source:Se Pu;28(1):23-33, 2010 Jan.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A rapid method for the simultaneous determination of 42 psychoactive drugs and their metabolites (barbitals, benzodiazepines, tricyclic antidepressants, phenothiazines, etc. ) in human plasma and urine was developed using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). After a simple protein precipitation step, the analysis of the drugs and the metabolites was achieved on an Acquity UPLC BEH C18 column by using the gradient elution with ammonium acetate and methanol-acetonitrile (1: 1, v/v) as the mobile phases, and detected by electrospray ionization-tandem mass spectrometry in the multiple reaction monitoring (MRM) mode operated simultaneously in both positive and negative modes by rapid switching, and quantified by matrix-match standard solution. The average recoveries were 60.2% - 125% and 64.5% - 126% for the drugs in plasma and urine except those of perphenazine, thioridazine and chloropromazine in plasma were 37.6% - 57.5%, 36.3% - 48.3%, 52.4% -67.4%, respectively; trazodone and diazepam in urine were 100% -142% and 108% - 177%, respectively. The relative standard deviations (RSDs) of all the drugs in plasma and urine were within 0.8% - 26% and 2.6%18% (n = 6), respectively. The detection limits of the 4 barbitals ranged from 20 to 100 mg/L and those of the other drugs ranged from 0.05 to 2.0 mg/L. The method is simple, selective and sensitive to detect drugs for both clinical and forensic purposes.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Psicotrópicos/sangue
Psicotrópicos/urina
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Antidepressivos Tricíclicos/sangue
Antidepressivos Tricíclicos/urina
Barbital/sangue
Barbital/urina
Benzodiazepinas/sangue
Benzodiazepinas/urina
Análise Química do Sangue/métodos
Seres Humanos
Psicotrópicos/metabolismo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antidepressive Agents, Tricyclic); 0 (Psychotropic Drugs); 12794-10-4 (Benzodiazepines); 5WZ53ENE2P (Barbital)
[Em] Mês de entrada:1112
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100513
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde