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[PMID]: | 26548500 |
[Au] Autor: | Bunney PE; Burroughs D; Hernandez C; LeSage MG |
[Ad] Endereço: | Department of Medicine, Minneapolis Medical Research Foundation, 701 Park Ave., Minneapolis, MN 55415, United States; Department of Medicine, University of Minnesota School of Medicine, 420 Delaware St. SE, Minneapolis, MN 55455, United States. Electronic address: pgrebenstein@mmrf.org. |
[Ti] Título: | The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats. |
[So] Source: | Physiol Behav;154:49-59, 2016 Feb 01. | [Is] ISSN: | 1873-507X |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Carbohydrate intake, preference, and taste thresholds may be altered in current and former cigarette smokers, which may mediate weight gain and risk for obesity in individuals who quit smoking. Attempts to model these effects in rodents have primarily used noncontingent nicotine administration. The purpose of this research was to characterize changes in chow and sucrose intake in rats during a 23-h access model of i.v. nicotine self-administration (NSA), in which rats lever-pressed for chow, sucrose, and nicotine under concurrent fixed-ratio (FR) 1 schedules. Male rats were assigned to one of three groups that differed in food and drug availability. The Nicotine C+S group had concurrent access to nicotine, chow, and sucrose. The Saline C+S group had access to saline, chow, and sucrose. The Nicotine C-Only group had access to nicotine and chow, but not sucrose. Changes in food intake and weight gain were assessed during baseline, NSA, and nicotine withdrawal (i.e., saline extinction). Weight gain was significantly slowed during NSA and increased during withdrawal, but did not differ between the nicotine groups. NSA produced a significant decrease in both chow and sucrose intake. Gradual tolerance to nicotine's effects on sucrose, but not chow intake, occurred. During withdrawal, chow and sucrose intake increased, with a larger percent increase in sucrose intake compared to chow. The proportion of total food intake from sucrose was greater at the end of withdrawal compared to baseline, indicating a history of nicotine intake changed dietary preference. Combined, these results indicate that sucrose intake is more resistant to nicotine's appetite suppressant effects and withdrawal from nicotine produces a greater increase in sweet food intake alongside general increases in chow intake. Changes in overall food intake in current and ex-smokers may lead to increased risk for obesity and other health problems, potentially limiting the benefit of quitting smoking. |
[Mh] Termos MeSH primário: |
Ingestão de Alimentos/efeitos dos fármacos Comportamento Alimentar/efeitos dos fármacos Preferências Alimentares/efeitos dos fármacos Nicotina/administração & dosagem Agonistas Nicotínicos/administração & dosagem
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[Mh] Termos MeSH secundário: |
Análise de Variância Anestésicos Intravenosos/farmacologia Animais Peso Corporal/efeitos dos fármacos Condicionamento Operante/efeitos dos fármacos Relação Dose-Resposta a Droga Extinção Psicológica/efeitos dos fármacos Masculino Metoexital/farmacologia Ratos Esquema de Reforço Autoadministração
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Anesthetics, Intravenous); 0 (Nicotinic Agonists); 6M3C89ZY6R (Nicotine); E5B8ND5IPE (Methohexital) |
[Em] Mês de entrada: | 1609 |
[Cu] Atualização por classe: | 170220 |
[Lr] Data última revisão:
| 170220 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 151110 |
[St] Status: | MEDLINE |
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