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[PMID]:28419925
[Au] Autor:Dos Santos RC; Kakazu AK; Santos MG; Belinelli Silva FA; Figueiredo EC
[Ad] Endereço:Toxicant and Drug Analysis Laboratory - LATF, Faculty of Pharmaceutical Sciences, Gabriel Monteiro da Silva St. 700, Federal University of Alfenas - UNIFAL-MG, 37130-000 Alfenas, MG, Brazil.
[Ti] Título:Characterization and application of restricted access carbon nanotubes in online extraction of anticonvulsant drugs from plasma samples followed by liquid chromatography analysis.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1054:50-56, 2017 Jun 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Anticonvulsant drugs are often used in the treatment of epilepsy. However, their therapeutic monitoring is often necessary in order to obtain an appropriate dose adjustment, due to the proximity between their therapeutic and toxic ranges. The aim of this study was to carry out the synthesis, characterization and use of restricted access carbon nanotubes (RACNTs) in an online method for the analyses of phenobarbital and carbamazepine and primidone from untreated human blood plasma by column switching liquid chromatography. Therefore, the synthesis of RACNTs was carried out through coating commercial Carbon nanotubes with bovine serum albumin (BSA) to subsequently use them as adsorbents in a column switching system operating in the backflush mode. This material was evaluated through the construction of the kinetic and isotherm curves. The experimental data for the interaction of primidone with RACNTs were adequately adjusted to the chemisorption and Sips models for the kinetic and adsorption studies, respectively. The analytical curves ranged from 2.0 to 40.0mgL , with correlation coefficients higher than 0.99, for all the analytes. The LODs of 0.1, 0.1 and 0.01µgmL were defined for PHB, PRM and CBZ, respectively. The relative standard deviation values ranged from 1.0% to 8.4% for the intra assay precision and from 2.7% to 7.6% for inter assay precision. The relative error values ranged from -13.4% to 7.7% for the intra assay accuracy and from -8.6% to 2.5% for the inter assay accuracy. The method was adequately used in the therapeutic monitoring of anticonvulsant drugs in human plasma samples.
[Mh] Termos MeSH primário: Anticonvulsivantes/sangue
Carbamazepina/sangue
Cromatografia Líquida de Alta Pressão/instrumentação
Nanotubos de Carbono/química
Fenobarbital/sangue
Primidona/sangue
[Mh] Termos MeSH secundário: Adsorção
Animais
Anticonvulsivantes/isolamento & purificação
Carbamazepina/isolamento & purificação
Bovinos
Desenho de Equipamento
Seres Humanos
Cinética
Limite de Detecção
Fenobarbital/isolamento & purificação
Primidona/isolamento & purificação
Soroalbumina Bovina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Nanotubes, Carbon); 13AFD7670Q (Primidone); 27432CM55Q (Serum Albumin, Bovine); 33CM23913M (Carbamazepine); YQE403BP4D (Phenobarbital)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28106668
[Au] Autor:Krügel U; Straub I; Beckmann H; Schaefer M
[Ad] Endereço:aRudolf-Boehm-Institut für Pharmakologie und Toxikologie, Universität Leipzig, Leipzig, Germany bCarl-Ludwig-Institut für Physiologie, Universität Leipzig, Leipzig, Germany.
[Ti] Título:Primidone inhibits TRPM3 and attenuates thermal nociception in vivo.
[So] Source:Pain;158(5):856-867, 2017 May.
[Is] ISSN:1872-6623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The melastatin-related transient receptor potential (TRP) channel TRPM3 is a nonselective cation channel expressed in nociceptive neurons and activated by heat. Because TRPM3-deficient mice show inflammatory thermal hyperalgesia, pharmacological inhibition of TRPM3 may exert antinociceptive properties. Fluorometric Ca influx assays and a compound library containing approved or clinically tested drugs were used to identify TRPM3 inhibitors. Biophysical properties of channel inhibition were assessed using electrophysiological methods. The nonsteroidal anti-inflammatory drug diclofenac, the tetracyclic antidepressant maprotiline, and the anticonvulsant primidone were identified as highly efficient TRPM3 blockers with half-maximal inhibition at 0.6 to 6 µM and marked specificity for TRPM3. Most prominently, primidone was biologically active to suppress TRPM3 activation by pregnenolone sulfate (PregS) and heat at concentrations markedly lower than plasma concentrations commonly used in antiepileptic therapy. Primidone blocked PregS-induced Cai influx through TRPM3 by allosteric modulation and reversibly inhibited atypical inwardly rectifying TRPM3 currents induced by coapplication of PregS and clotrimazole. In vivo, analgesic effects of low doses of primidone were demonstrated in mice, applying PregS- and heat-induced pain models, including inflammatory hyperalgesia. Thus, applying the approved drug at concentrations that are lower than those needed to induce anticonvulsive effects offers a shortcut for studying physiological and pathophysiological roles of TRPM3 in vivo.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Hiperalgesia/tratamento farmacológico
Dor/fisiopatologia
Pregnenolona/toxicidade
Primidona/uso terapêutico
Canais de Cátion TRPM/metabolismo
[Mh] Termos MeSH secundário: Inibidores da Captação Adrenérgica/farmacologia
Inibidores da Captação Adrenérgica/uso terapêutico
Analgésicos/farmacologia
Animais
Anti-Inflamatórios não Esteroides/farmacologia
Anti-Inflamatórios não Esteroides/uso terapêutico
Cálcio/metabolismo
Diclofenaco/farmacologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Gânglios Espinais/citologia
Células HEK293
Seres Humanos
Hiperalgesia/etiologia
Masculino
Maprotilina/farmacologia
Maprotilina/uso terapêutico
Potenciais da Membrana/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Neurônios/efeitos dos fármacos
Dor/induzido quimicamente
Limiar da Dor/efeitos dos fármacos
Técnicas de Patch-Clamp
Primidona/química
Primidona/farmacologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic Uptake Inhibitors); 0 (Analgesics); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (TRPM Cation Channels); 0 (TRPM3 protein, mouse); 13AFD7670Q (Primidone); 144O8QL0L1 (Diclofenac); 2U1W68TROF (Maprotiline); 73R90F7MQ8 (Pregnenolone); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1097/j.pain.0000000000000846


  3 / 1118 MEDLINE  
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[PMID]:26757316
[Au] Autor:Louis ED; Hernandez N; Dyke JP; Ma R; Dydak U
[Ad] Endereço:*Department of Neurology, Yale School of Medicine; †Department of Chronic Disease Epidemiology, Yale School of Public Health; ‡Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, Yale University, New Haven, CT; §Department of Radiology, Weill Cornell Medical College, New York, NY; ∥School of Health Sciences, Purdue University, West Lafayette; and ¶Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.
[Ti] Título:Effect of Primidone on Dentate Nucleus γ-Aminobutyric Acid Concentration in Patients With Essential Tremor.
[So] Source:Clin Neuropharmacol;39(1):24-8, 2016 Jan-Feb.
[Is] ISSN:1537-162X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: It is not known whether current use of the medication primidone affects brain γ-aminobutyric acid (GABA) concentrations. This is an important potential confound in studies of the pathophysiology of essential tremor (ET), one of the most common neurological diseases. We compared GABA concentrations in the dentate nucleus in 6 ET patients taking primidone versus 26 ET patients not taking primidone. METHODS: (1)H magnetic resonance spectroscopy was performed using a 3.0-T Siemens Tim Trio scanner. The MEGA-PRESS J-editing sequence was used for GABA detection in 2 cerebellar volumes of interest (left and right) that included the dentate nucleus. RESULTS: The right dentate GABA concentration was similar in the 2 groups (2.21 ± 0.46 [on primidone] vs 1.93 ± 0.39 [not on primidone], P = 0.15), as was the left dentate GABA concentration (1.61 ± 0.35 [on primidone] vs 1.67 ± 0.34 [not on primidone], P = 0.72). The daily primidone dose was not associated with either right or left dentate GABA concentrations (P = 0.89 and 0.76, respectively). CONCLUSIONS: We did not find a difference in dentate GABA concentrations between 6 ET patients taking daily primidone and 26 ET patients not taking primidone. Furthermore, there was no association between daily primidone dose and dentate GABA concentration. These data suggest that it is not necessary to exclude ET patients on primidone from magnetic resonance spectroscopy studies of dentate GABA concentration, and if assessment of these concentrations was to be developed as a biomarker for ET, primidone usage would not confound interpretation of the results.
[Mh] Termos MeSH primário: Anticonvulsivantes/uso terapêutico
Núcleos Cerebelares/efeitos dos fármacos
Tremor Essencial/tratamento farmacológico
Tremor Essencial/patologia
Primidona/uso terapêutico
Ácido gama-Aminobutírico/metabolismo
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Núcleos Cerebelares/metabolismo
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Ligação Proteica/efeitos dos fármacos
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Anticonvulsants); 13AFD7670Q (Primidone); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160113
[St] Status:MEDLINE
[do] DOI:10.1097/WNF.0000000000000127


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[PMID]:26660910
[Au] Autor:Nida A; Alston J; Schweinfurth J
[Ad] Endereço:Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson.
[Ti] Título:Primidone Therapy for Essential Vocal Tremor.
[So] Source:JAMA Otolaryngol Head Neck Surg;142(2):117-21, 2016 Feb.
[Is] ISSN:2168-619X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IMPORTANCE: Essential vocal tremor is difficult to treat. An effective pharmacologic treatment could allow patients to avoid or decrease the frequency or dosage of botulinum neurotoxin injections. OBJECTIVE: To evaluate the efficacy of primidone in the treatment of essential vocal tremor. DESIGN, SETTING, AND PARTICIPANTS: Medical records of all patients with a primary or secondary diagnosis of laryngeal spasm or essential tremor treated with primidone between June 1, 2012, and March 21, 2014, at a tertiary care medical center were reviewed. Data analysis occurred in April 2014. MAIN OUTCOMES AND MEASURES: Duration of therapy, improvement of symptoms, and whether the patient subsequently initiated botulinum neurotoxin therapy. RESULTS: All 30 patients were female (mean [SD] age, 71.9 [11.8] years). Mean (SD) therapy duration was 5.25 (7.22) months. Nine patients (30%) had other vocal conditions (4 had coexisting spasmodic dysphonia, 4 had laryngopharyngeal reflux disease, and 1 had muscle tension dysphonia). Twelve (40%) had previously undergone treatment. Fourteen of 26 patients (54%) reported an improvement in their vocal symptoms, and 16 of 29 (55%) did not discontinue primidone therapy. Twenty-two of 30 patients (73%) experienced adverse effects. Therapy was discontinued by 11 of 21 patients (52%) who experienced adverse effects and 2 of 8 patients (25%) who did not report adverse effects (P = .24) (1 patient who had adverse effects was missing data on discontinuation of therapy). Sixteen patients (53%) subsequently initiated botulinum toxin therapy, including 5 of 14 patients (36%) who reported clinical improvement with primidone therapy and 7 of 12 patients (58%) who did not report improvement (P = .43). CONCLUSIONS AND RELEVANCE: Primidone therapy was an effective pharmacologic treatment for essential vocal tremor in 14 of 26 patients in this case series, providing an alternative to botulinum neurotoxin therapy.
[Mh] Termos MeSH primário: Músculos Laríngeos/efeitos dos fármacos
Primidona/uso terapêutico
Qualidade da Voz
[Mh] Termos MeSH secundário: Idoso
Toxinas Botulínicas Tipo A/uso terapêutico
Feminino
Seres Humanos
Injeções Intramusculares
Músculos Laríngeos/fisiopatologia
Fármacos Neuromusculares/uso terapêutico
Estudos Retrospectivos
Resultado do Tratamento
Disfunção da Prega Vocal/tratamento farmacológico
Disfunção da Prega Vocal/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuromuscular Agents); 13AFD7670Q (Primidone); EC 3.4.24.69 (Botulinum Toxins, Type A)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160219
[Lr] Data última revisão:
160219
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1001/jamaoto.2015.2849


  5 / 1118 MEDLINE  
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[PMID]:26163145
[Au] Autor:Riepe MW; Walther B; Vonend C; Beer AJ
[Ad] Endereço:Division of Mental Health & Old Age Psychiatry, Psychiatry II, University of Ulm, Ludwig-Heilmeyer-Strasse 2, D-89312, Günzburg, Germany. matthias.riepe@uni-ulm.de.
[Ti] Título:Drug-induced cerebral glucose metabolism resembling Alzheimer's Disease: a case study.
[So] Source:BMC Psychiatry;15:157, 2015 Jul 11.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: With aging of society the absolute number and the proportion of patients with cognitive deficits increase. Multiple disorders and diseases can foster cognitive impairment, e.g., Alzheimer's disease (AD), depressive disorder, or polypharmacy. CASE PRESENTATION: A 74 year old man presented to the Old Age Psychiatry Service with cognitive deficits while being treated for recurrent depressive episodes and essential tremor with Venlafaxine, Lithium, and Primidone. Neuropsychological testing revealed a medio-temporal pattern of deficits with pronounced impairment of episodic memory, particularly delayed recall. Likewise, cognitive flexibility, semantic fluency, and attention were impaired. Positron emission tomography (PET) with fluorodeoxyglucose was performed and revealed a pattern of glucose utilization deficit resembling AD. On cessation of treatment with Lithium and Primidone, cognitive performance improved, particularly episodic memory performance and cognitive flexibility. Likewise, glucose metabolism normalized. Despite normalization of both, clinical symptoms and glucose utilization, the patient remained worried about possible underlying Alzheimer's disease pathology. To rule this out, an amyloid-PET was performed. No cortical amyloid was observed. CONCLUSION: Pharmacological treatment of older subjects may mimic glucose metabolism and clinical symptoms of Alzheimer's disease. In the present case both, imaging and clinical findings, reversed to normal on change of treatment. Amyloid PET is a helpful tool to additionally rule out underlying Alzheimer's disease in situations of clinical doubt even if clinical or other imaging findings are suggestive of Alzheimer's disease.
[Mh] Termos MeSH primário: Antidepressivos/efeitos adversos
Transtornos Cognitivos/induzido quimicamente
Transtorno Depressivo Maior/tratamento farmacológico
Transtornos do Metabolismo de Glucose/induzido quimicamente
Transtornos da Memória/induzido quimicamente
[Mh] Termos MeSH secundário: Idoso
Doença de Alzheimer/diagnóstico por imagem
Anticonvulsivantes/efeitos adversos
Atenção/efeitos dos fármacos
Transtornos Cognitivos/diagnóstico por imagem
Transtorno Depressivo Maior/diagnóstico por imagem
Diagnóstico Diferencial
Quimioterapia Combinada
Tremor Essencial/tratamento farmacológico
Fluordesoxiglucose F18
Transtornos do Metabolismo de Glucose/diagnóstico por imagem
Seres Humanos
Compostos de Lítio/efeitos adversos
Masculino
Transtornos da Memória/diagnóstico por imagem
Memória Episódica
Rememoração Mental/efeitos dos fármacos
Testes Neuropsicológicos
Tomografia por Emissão de Pósitrons/métodos
Primidona/efeitos adversos
Compostos Radiofarmacêuticos
Recidiva
Cloridrato de Venlafaxina/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Antidepressive Agents); 0 (Lithium Compounds); 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 13AFD7670Q (Primidone); 7D7RX5A8MO (Venlafaxine Hydrochloride)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150712
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-015-0531-9


  6 / 1118 MEDLINE  
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[PMID]:24798495
[Au] Autor:Dong MM; Trenholm R; Rosario-Ortiz FL
[Ad] Endereço:Civil, Environmental and Architectural Engineering, 428 UCB, University of Colorado, Boulder, CO 80309, USA; Southern Nevada Water Authority (SNWA), P.O. Box 99954, Las Vegas, NV 89193-9954, USA.
[Ti] Título:Photochemical degradation of atenolol, carbamazepine, meprobamate, phenytoin and primidone in wastewater effluents.
[So] Source:J Hazard Mater;282:216-23, 2015 Jan 23.
[Is] ISSN:1873-3336
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The photochemical degradation of five pharmaceuticals was examined in two secondary wastewater effluents. The compounds, which included atenolol, carbamazepine, meprobamate, phenytoin and primidone, were evaluated for both direct and sensitized photolysis. In the two wastewaters, direct photolysis did not lead to significant compound degradation; however, sensitized photolysis was an important removal pathway for the five pharmaceuticals. Upon solar irradiation, hydroxyl radical (HO) was quantified using the hydroxylation of benzene and singlet oxygen ((1)O2) formation was monitored following the degradation of furfuryl alcohol. Degradation via sensitized photolysis was observed following five-day exposures for atenolol (69-91%), carbamazepine (67-98%), meprobamate (16-52%), phenytoin (44-85%), and primidone (34-88%). Varying removal is likely a result of the differences in reactivity with transient oxidants. Averaged steady state HO concentrations ranged from 1.2 to 4.0×10(-16)M, whereas the concentrations of (1)O2 were 6.0-7.6×10(-14)M. Partial removal due to presence of HO indicates it was not the major sink for most compounds examined. Other transient oxidants, such as (1)O2 and triplet state effluent organic matter, are likely to play important roles in fates of these compounds.
[Mh] Termos MeSH primário: Radical Hidroxila/química
Luz Solar
Poluentes Químicos da Água/química
Poluentes Químicos da Água/efeitos da radiação
[Mh] Termos MeSH secundário: Atenolol/química
Carbamazepina/química
Meprobamato/química
Oxidantes/química
Fenitoína/química
Fotólise
Primidona/química
Oxigênio Singlete/química
Eliminação de Resíduos Líquidos/métodos
Águas Residuais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Oxidants); 0 (Waste Water); 0 (Water Pollutants, Chemical); 13AFD7670Q (Primidone); 17778-80-2 (Singlet Oxygen); 3352-57-6 (Hydroxyl Radical); 33CM23913M (Carbamazepine); 50VV3VW0TI (Atenolol); 6158TKW0C5 (Phenytoin); 9I7LNY769Q (Meprobamate)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141203
[Lr] Data última revisão:
141203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140507
[St] Status:MEDLINE


  7 / 1118 MEDLINE  
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[PMID]:24712318
[Au] Autor:Celik S; Kecel-Gunduz S; Ozel AE; Akyuz S
[Ad] Endereço:a Engineering Faculty, Electrical-Electronics Engineering Department , Istanbul University , Avcilar 34320 , Istanbul , Turkey.
[Ti] Título:Structural and vibrational study of primidone based on monomer and dimer calculations.
[So] Source:J Biomol Struct Dyn;33(4):911-23, 2015.
[Is] ISSN:1538-0254
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Primidone (Mysoline), with the chemical formula 5-ethyl-5-phenyl-hexahydropyrimidine- 4,6-dione (C12H14N2O2), has been a valuable drug in the treatment of epilepsy. In the present work, the experimental IR and Raman spectra of solid phase primidone were recorded, and the results were compared with theoretical wavenumber values of monomer and dimer forms of the title molecule. Vibrational spectral simulations in the dimer form were carried out to improve the assignment of the bands in the solid phase experimental spectra. The possible stable conformers of free molecule were searched by means of torsion potential energy surfaces scan studies through two dihedral angles. The molecular geometries of the monomer and dimer forms of title molecule were optimized using DFT method at B3LYP/6-31++G(d,p) level of theory. Using PEDs determined the contributions of internal (stretching, bending, etc.) coordinates to each normal mode of vibration. Further, HOMO-LUMO energy gap and NBO properties of the investigated molecule in monomer and dimer forms were also calculated.
[Mh] Termos MeSH primário: Anticonvulsivantes/química
Primidona/química
[Mh] Termos MeSH secundário: Ligações de Hidrogênio
Modelos Químicos
Modelos Moleculares
Conformação Molecular
Teoria Quântica
Espectroscopia de Infravermelho com Transformada de Fourier
Análise Espectral Raman
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anticonvulsants); 13AFD7670Q (Primidone)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150124
[Lr] Data última revisão:
150124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140410
[St] Status:MEDLINE
[do] DOI:10.1080/07391102.2014.913505


  8 / 1118 MEDLINE  
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[PMID]:23973619
[Au] Autor:Wu X; Ernst F; Conkle JL; Gan J
[Ad] Endereço:Department of Environmental Sciences, University of California, Riverside, CA 92521, USA.
[Ti] Título:Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables.
[So] Source:Environ Int;60:15-22, 2013 Oct.
[Is] ISSN:1873-6750
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Reuse of treated wastewater to irrigate agricultural crops is increasing in many arid and semi-arid areas around the world. The presence of numerous pharmaceutical and personal care products (PPCPs) in treated wastewater and their potential transfer into food produce such as vegetables poses an unknown human health risk. The goal of this study was to identify PPCPs that have a comparatively high potential for plant uptake and translocation. A total of 20 frequently-occurring PPCPs were compared for their accumulation into four staple vegetables (lettuce, spinach, cucumber, and pepper) grown in nutrient solutions containing PPCPs at 0.5 or 5µgL(-1). Triclocarban, fluoxetine, triclosan, and diazepam were found at high levels in roots, while meprobamate, primidone, carbamazepine, dilantin, and diuron exhibited more active translocation from roots to leaves. Root uptake of neutral PPCPs was positively correlated with the pH adjusted log Kow(i.e., log Dow), and was likely driven by chemical adsorption onto the root surfaces. In contrast, translocation from roots to leaves was negatively related to log Dow, suggesting hydrophilicity-regulated transport via xylems. Compounds preferentially sorbed to roots should be further evaluated for their uptake in tuber vegetables (e.g., carrot, radish) under field conditions, while those easily translocated into leaves (e.g., carbamazepine, dilantin) merit focused consideration for leafy and other vegetables (e.g., lettuce, cucumber). However, estimation of dietary intake by humans suggested the implied risks from exposure to PPCPs via wastewater irrigation to be negligible.
[Mh] Termos MeSH primário: Produtos Domésticos/análise
Preparações Farmacêuticas/análise
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
Verduras/química
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/farmacocinética
[Mh] Termos MeSH secundário: Adsorção
Carbanilidas/análise
Carbanilidas/farmacocinética
Diazepam/análise
Diazepam/farmacocinética
Fluoxetina/análise
Fluoxetina/farmacocinética
Meprobamato/análise
Meprobamato/farmacocinética
Folhas de Planta/química
Raízes de Plantas/química
Primidona/análise
Primidona/farmacocinética
Distribuição Tecidual
Triclosan/análise
Triclosan/farmacocinética
Águas Residuais/análise
Águas Residuais/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Carbanilides); 0 (Pharmaceutical Preparations); 0 (Waste Water); 0 (Water Pollutants, Chemical); 01K63SUP8D (Fluoxetine); 13AFD7670Q (Primidone); 4NM5039Y5X (Triclosan); 9I7LNY769Q (Meprobamate); BGG1Y1ED0Y (triclocarban); Q3JTX2Q7TU (Diazepam)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:131104
[Lr] Data última revisão:
131104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130827
[St] Status:MEDLINE


  9 / 1118 MEDLINE  
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[PMID]:23542519
[Au] Autor:Arjunan V; Santhanam R; Subramanian S; Mohan S
[Ad] Endereço:Department of Chemistry, Kanchi Mamunivar Centre for Post-Graduate Studies, Puducherry 605 008, India. varjunftir@yahoo.com
[Ti] Título:Primidone--an antiepileptic drug--characterisation by quantum chemical and spectroscopic (FTIR, FT-Raman, 1H, 13C NMR and UV-Visible) investigations.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;109:282-97, 2013 May 15.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The solid phase FTIR and FT-Raman spectra of primidone were recorded in the regions 4000-400 cm(-1) and 4000-100 cm(-1), respectively. The vibrational spectra were analysed and the observed fundamentals were assigned and analysed. The experimental wavenumbers were compared with the theoretical scaled vibrational wavenumbers determined by DFT methods. The Raman intensities were also determined with B3LYP/6-31G(d,p) method. The total electron density and molecular electrostatic potential surface of the molecule were constructed by using B3LYP/6-311++G(d,p) method to display electrostatic potential (electron+nuclei) distribution. The HOMO and LUMO energies were measured. Natural bond orbital analysis of primidone has been performed to indicate the presence of intramolecular charge transfer. The (1)H and (13)C NMR spectra were recorded and the chemical shifts of the molecule were calculated.
[Mh] Termos MeSH primário: Anticonvulsivantes/química
Primidona/química
[Mh] Termos MeSH secundário: Ligações de Hidrogênio
Espectroscopia de Ressonância Magnética
Modelos Moleculares
Teoria Quântica
Espectrofotometria Ultravioleta
Espectroscopia de Infravermelho com Transformada de Fourier
Análise Espectral Raman
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 13AFD7670Q (Primidone)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:130425
[Lr] Data última revisão:
130425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130402
[St] Status:MEDLINE


  10 / 1118 MEDLINE  
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[PMID]:23503440
[Au] Autor:Tanoshima R; 't Jong GW; Merlocco A; Simpson J; Friedman JN; Colantonio D; Koren G
[Ad] Endereço:Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.
[Ti] Título:A child exposed to primidone not prescribed for her.
[So] Source:Ther Drug Monit;35(2):145-9, 2013 Apr.
[Is] ISSN:1536-3694
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 7.5-year-old girl who was treated with phenobarbital (PHB) for epilepsy was admitted with decreased levels of consciousness. She had been known to have high PHB levels of unknown cause, without symptoms. Her PHB levels were very high, as expected, but primidone levels were also detected although she and her parents denied history of primidone administration. We wished to rule out intentional unprescribed use of primidone. Our retrospective review showed 3 other children with high PHB concentrations where primidone was also detected when PHB levels were over 130 µmol/L. Complementary studies confirmed that high-dose PHB can convert to its prodrug primidone, which has not been reported previously.
[Mh] Termos MeSH primário: Anticonvulsivantes/efeitos adversos
Anticonvulsivantes/uso terapêutico
Fenobarbital/efeitos adversos
Primidona/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Criança
Epilepsia/tratamento farmacológico
Feminino
Gastroenteropatias/induzido quimicamente
Gastroenteropatias/diagnóstico
Seres Humanos
Fenobarbital/uso terapêutico
Primidona/uso terapêutico
Ratos
Ratos Sprague-Dawley
Estudos Retrospectivos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticonvulsants); 13AFD7670Q (Primidone); YQE403BP4D (Phenobarbital)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:130318
[Lr] Data última revisão:
130318
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130319
[St] Status:MEDLINE
[do] DOI:10.1097/FTD.0b013e3182843206



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