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[PMID]:24195209
[Au] Autor:Gao YL; Yao JH; Guo JX
[Ad] Endereço:Department of Acupuncture-Moxibustion and Tuina, Affiliated Hospital of Zhangye Medical Junior School, Zhangye 734000, Gansu Province, China. gaoyanglai@yahoo.cn
[Ti] Título:[Clinical observation on fire needles at bones combined with cupping and Tuina for knee osteoarthritistis].
[So] Source:Zhongguo Zhen Jiu;33(8):697-9, 2013 Aug.
[Is] ISSN:0255-2930
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To explore a better therapy for knee osteoarthritis. METHODS: One hundred cases were randomly divided into a comprehensive group and an acupuncture group, 50 cases in each one. The comprehensive treatment of fire needles at bones combined with cupping and Tuina on local area of affected knee was applied in the comprehensive group. The Ashi points were mainly selected in the fire needles at bones therapy, once every other day. The cupping and Tuina therapy was adopted once a day. The conventional acupuncture was applied in the acupuncture group, in which Dubi (ST 35), Neixiyan (EX-LE 4), Xuehai (SP 10), Liangqiu (ST 34) and so on were selected, once a day. Ten days of treatment were taken as a treatment course in both two groups, and totally 1 to 2 courses was required. The pain score of joint before and after the treatment was observed and efficacy was assessed in two groups. RESULTS: Compared before the treatment, the pain score of joint after the treatment was obviously improved in two groups (both P<0.05), and the score in the comprehensive group was lower than that in the acupuncture group (P<0.05). The clinical cured rate was 38.0% (19/50), which was superior to 20.0% (10/50) in the acupuncture group. CONCLUSION: The comprehensive treatment of fire needles at bones combined with cupping and Tuina, considered as a better therapy for knee osteoarthritis, could improve joint pain, swelling and action function, which is superior to the conventional acupuncture.
[Mh] Termos MeSH primário: Terapia por Acupuntura
Amobarbital/uso terapêutico
Artralgia/terapia
Osteoartrite do Joelho/terapia
Secobarbital/uso terapêutico
[Mh] Termos MeSH secundário: Terapia por Acupuntura/instrumentação
Idoso
Terapia Combinada
Combinação de Medicamentos
Feminino
Seres Humanos
Masculino
Medicina Tradicional Chinesa
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drug Combinations); 0 (amobarbital, secobarital drug combination); 1P7H87IN75 (Secobarbital); GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:131107
[Lr] Data última revisão:
131107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131108
[St] Status:MEDLINE


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[PMID]:23072081
[Au] Autor:Wang T; Wu ZC; Zhu TR; Wang WY
[Ad] Endereço:Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Hospital of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
[Ti] Título:[Impacts on biomechanics of senile osteoporosis of kidney deficiency pattern treated with acupuncture and Tuina therapy].
[So] Source:Zhongguo Zhen Jiu;32(8):685-8, 2012 Aug.
[Is] ISSN:0255-2930
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To explore the mechanism on senile osteoporosis of kidney deficiency pattern in the prevention and treatment with acupuncture and Tuina therapy. METHODS: Sixty-four cases were randomized into an acupuncture and Tuina therapy group (group A, 34 cases) and a calcium carbonate group (group B, 30 cases). In group A, the patients were treated with acupuncture at the distal acupoints and Tuina therapy in the local area. Acupuncture was applied to bilateral Weizhong (BL 40) and Taixi (KI 3). Tuina therapy was given in the lumbar region. Totally 30 treatments were required. In group B, the Calcium Carbonate D3 were prescribed for oral administration, continuously for 12 weeks. The changes in lumbar curvature, lumbar lordosis index, sacral inclination angle, lumbosacral angle, L5 vertebral index and L3 vertebral index of lumbar biomechanical indices were observed and compared before and after treatment in two groups. RESULTS: In group A, the lumbar lordosis index and sacral inclination angle were increased after treatment, indicating the statistical significant differences before and after treatment (P < 0.05, P < 0.01). The improvement of lumbar lordosis index in group A was superior to that in group B [(19.59 +/- 19.16)mm vs (14.47 +/- 13.28)mm, P < 0.05]. After treatment, in group B, L5 vertebral index was improved as compared with that before treatment (P < 0.05). It was required to have a study on the reasons of its lumbar morphological change. CONCLUSION: The acupuncture and Tuina therapy regulate the lumbar biomechanical structure through the positive stress stimulation and reconstruct the mechanical equilibrium of the lumbar vertebra. It plays the active significance in the prevention and treatment of osteoporosis.
[Mh] Termos MeSH primário: Terapia por Acupuntura
Amobarbital
Rim/fisiopatologia
Osteoporose/fisiopatologia
Osteoporose/terapia
Secobarbital
[Mh] Termos MeSH secundário: Pontos de Acupuntura
Idoso
Fenômenos Biomecânicos
Terapia Combinada
Combinação de Medicamentos
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drug Combinations); 0 (amobarbital, secobarital drug combination); 1P7H87IN75 (Secobarbital); GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1212
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121018
[St] Status:MEDLINE


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[PMID]:22493925
[Au] Autor:Zheng JJ; Zhao Y; Lu P; Wang XY
[Ad] Endereço:College of Acupuncture and Massage, Shanghai University of TCM, Shanghai 201203, China.
[Ti] Título:[Effect of Tuina at breast on postpartum lactation].
[So] Source:Zhongguo Zhen Jiu;32(2):159-61, 2012 Feb.
[Is] ISSN:0255-2930
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To explore the efficacy of Tuina for postpartum lactation and work out a optimal protocol involved. METHODS: With a randomized, controlled and clinical method, 84 primiparas were divided into a Tuina group and a control group. While patients in the control group received rooming-in conventional managements, those in the Tuina group were additionally treated with Tuina, including local manipulations on breasts combined with acupoint manipulations. The colostrum-time, lactation quantity and prolactin were observed to make the comparisons between two groups. RESULTS: The scores of lactation quantity after 1th, 2nd, 3rd of the treatment were 1.660 +/- 0.785, 2.530 +/- 1.030, 2.880 +/- 1.171 in Tuina group and 1.270 +/- 0.533, 1.460 +/- 0.811, 1.500 +/- 0.583 in control group respectively, where there were significant differences in each time stage between two groups (all P < 0.001). The time of colostrum was (21.6 6 +/- 10.508) h in the Tuina group and (22.5 +/- 9.762) h in the control group, in which the difference was not statistically significant (P > 0.05). The levels of prolactin (314.35 +/- 110.37) ng/mL and (321.56 +/- 109.61) ng/mL in Tuina group, (385.78 +/- 85.19) ng/mL and (340.12 +/- 103.10) ng/mL in control group before and after treatment, there were no significant differences (both P > 0.05). CONCLUSION: Postpartum Tuina on breasts could increase the quantity of lactation and delay the decreasing of the levels of prolactin, which contributes primiparas to lactate more and sooner.
[Mh] Termos MeSH primário: Amobarbital
Mama/secreção
Lactação
Leite Humano/secreção
Período Pós-Parto/fisiologia
Secobarbital
[Mh] Termos MeSH secundário: Adulto
Aleitamento Materno
Colostro/secreção
Combinação de Medicamentos
Feminino
Seres Humanos
Prolactina/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drug Combinations); 0 (amobarbital, secobarital drug combination); 1P7H87IN75 (Secobarbital); 9002-62-4 (Prolactin); GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120413
[St] Status:MEDLINE


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[PMID]:22493908
[Au] Autor:Li N; Tian FW; Wang CW; Yu PM; Zhou X; Wen Q; Qiao XL; Huang L
[Ad] Endereço:Huaxi Hospital of Sichuan University, Integrated TCM and Western Medicine Department, Chengdu 610041, China. zhenjiuhuaxi@163.com
[Ti] Título:[Double-center randomized controlled trial on post-stroke shoulder pain treated by electroacupuncture combined with Tuina].
[So] Source:Zhongguo Zhen Jiu;32(2):101-5, 2012 Feb.
[Is] ISSN:0255-2930
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To evaluate clinical therapeutic effect of post-stroke shoulder pain treated by acupuncture combined with Tuina. METHODS: Three hundred cases of post-stroke shoulder pain were randomly divided into an acupuncture and Tuina group and a rehabilitation group by double-center randomized controlled clinical trial method. In acupuncture and Tuina group, normalized electroacupuncture and Tuina therapy were applied, that was electroacupuncture at main points, such as Chize (LU 5), Quze (PC 3), Shaohai (HT 3), Jianyu (LI 15), Jianliao (TE 14) and Jianjing (GB 21),etc., combined with traditional Tuina manipulations; in rehabilitation group, the rehabilitation methods such as the electrostimulation through nervus cutaneus and the squeezing and stabilizing manipulations of Proprioceptive Neuromuscular Facilitation (PNF), etc. were applied. The treatment courses of both groups were 6 weeks. The main therapeutic effect indices were the Assessment Face Scale (AFS) for pain when shoulder was in passive motion and the Fugl-Meyer Motor Assessment for upper limbs active function; the secondary indices were the moditied Rankin Scale (mRS) and the clinical incidences of shoulder-hand syndrome of hemiplegia and shoulder joint subluxation of hemiplegia. RESULTS: After 6 weeks treatment and 12 weeks follow-up, AFS score, Fugl-Meyer motor assessment of upper limbs active function and mRS evaluation in acupuncture and Tuina group were more obviously improved than those in rehabilitation group (P < 0.05, P < 0.01). Although the clinical incidences of shoulder-hand syndrome of hemiplegia and shoulder joint subluxation of hemiplegia in acupuncture and Tuina group was equal to those in rehabilitation group [3.55% (5/141) vs 8.45% (12/142), 1.42% (2/141) vs 5.63% (8/142), both P > 0.05], the data indicated that there was a superiority tendency in acupuncture and Tuina group. CONCLUSION: The combined therapy of electroacupuncture and Tuina is a normative manipulation, and the therapeutic effect is satisfying for post-stroke shoulder pain, superior to that of comprehensive rehabilitation treatment.
[Mh] Termos MeSH primário: Amobarbital
Eletroacupuntura
Secobarbital
Dor de Ombro/terapia
Acidente Vascular Cerebral/complicações
[Mh] Termos MeSH secundário: Idoso
Terapia Combinada
Combinação de Medicamentos
Feminino
Seres Humanos
Masculino
Meia-Idade
Amplitude de Movimento Articular
Dor de Ombro/etiologia
Dor de Ombro/fisiopatologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drug Combinations); 0 (amobarbital, secobarital drug combination); 1P7H87IN75 (Secobarbital); GWH6IJ239E (Amobarbital)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120413
[St] Status:MEDLINE


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[PMID]:22476037
[Au] Autor:Claus S; Velis D; Lopes da Silva FH; Viergever MA; Kalitzin S
[Ad] Endereço:Department of Clinical Neurophysiology, Stichting Epilepsy Instellingen Nederland, Epilepsy Institutes in The Netherlands, SEIN, Heemstede, The Netherlands. sclaus@sein.nl
[Ti] Título:High frequency spectral components after secobarbital: the contribution of muscular origin--a study with MEG/EEG.
[So] Source:Epilepsy Res;100(1-2):132-41, 2012 Jun.
[Is] ISSN:1872-6844
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Previously we found that benzodiazepines not only provoke beta-activity in the EEG, but also higher frequency activity. Knowing the origin of this high frequency activity is crucial if localisation of epileptogenic brain tissue is the query. We attempt to differentiate cerebral from muscular origin of such activity. METHODS: We postulate that EEG and MEG have similar sensitivity to brain activity, but different sensitivity to muscle activity, and compare co-recorded EEG and MEG signals in a group of five patients who had received short-lasting barbiturates to induce sleep. We performed principal components analysis over time and subtract the results for MEG from the EEG to see where the frequency spectra differ. RESULTS: The EEG showed activity in the gamma bands up to 270Hz for all patients; the MEG significantly less. We find no differences in the lower frequency bands. Topographically the differences localized over the frontotemporal regions. CONCLUSIONS: In the EEG benzodiazepines and/or barbiturates are not only associated with frequencies in the beta band, but also with wide range gamma activity. The latter seems to be of muscular origin. SIGNIFICANCE: Our study suggests that gamma activity in such measurements may not be cerebral in origin. MEG is less susceptible to contamination from muscle activity than the EEG.
[Mh] Termos MeSH primário: Eletroencefalografia/efeitos dos fármacos
Hipnóticos e Sedativos/farmacologia
Magnetoencefalografia/efeitos dos fármacos
Músculo Esquelético/efeitos dos fármacos
Secobarbital/farmacologia
[Mh] Termos MeSH secundário: Adulto
Criança
Eletroencefalografia/métodos
Feminino
Seres Humanos
Magnetoencefalografia/métodos
Masculino
Músculo Esquelético/fisiologia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); 1P7H87IN75 (Secobarbital)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120406
[St] Status:MEDLINE
[do] DOI:10.1016/j.eplepsyres.2012.02.002


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[PMID]:22295813
[Au] Autor:Wang T; Pang L; Huang H; Wang WY
[Ad] Endereço:Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
[Ti] Título:[Observation on influence of bone metabolism biochemical indices of senile osteoporosis treated with distant acupuncture and nearby tuina].
[So] Source:Zhongguo Zhen Jiu;32(1):13-6, 2012 Jan.
[Is] ISSN:0255-2930
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To observe the influence of bone metabolism biochemical indices of senile osteoporosis treated with distant acupuncture and nearby tuina, and to probe the better therapy for senile osteoporosis. METHODS: Sixty-four cases were randomly divided into an observation group and a control group. In control group (30 cases), Calcium Carbonate D, Tablet was orally taken for 12 weeks continuously. In observation group (34 cases), "distant acupuncture and nearby tuina" therapy were applied, that was puncture at Weizhong (BL 40) and Taixi (KI 3), and tuina therapy on lumber region, 30 times treatment was applied totally. The changes of blood calcium (Ca), phosphorus (P), ALP, BGP and urine DPD in bone metabolism biochemical indices were observed and compared before and after treatment in two groups. RESULTS: There were significant differences in P, BGP, DPD in bone metabolism biochemical indices in both groups before and after treatment (P < 0.05, P < 0.01), the contents of blood P decreased, blood BGP increased and urine DPD decreased. But, there were no significant differences in above indices between two groups. CONCLUSION: The calcium with oral administration and "distant acupuncture and nearby tuina" therapy can effectively improve the bone metabolism biochemical indices of senile osteoporosis, and they have positive significance in prevention of osteoporosis, however, it hasn't proved that which method is better for calcium protecting.
[Mh] Termos MeSH primário: Terapia por Acupuntura
Amobarbital
Osso e Ossos/metabolismo
Osteoporose/terapia
Secobarbital
[Mh] Termos MeSH secundário: Idoso
Fosfatase Alcalina/sangue
Cálcio/sangue
Terapia Combinada
Combinação de Medicamentos
Feminino
Seres Humanos
Masculino
Meia-Idade
Osteocalcina/sangue
Osteoporose/sangue
Osteoporose/metabolismo
Fósforo/sangue
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drug Combinations); 0 (amobarbital, secobarital drug combination); 104982-03-8 (Osteocalcin); 1P7H87IN75 (Secobarbital); 27YLU75U4W (Phosphorus); EC 3.1.3.1 (Alkaline Phosphatase); GWH6IJ239E (Amobarbital); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1203
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120203
[St] Status:MEDLINE


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[PMID]:21099741
[Au] Autor:Fritch D; Blum K; Nonnemacher S; Kardos K; Buchhalter AR; Cone EJ
[Ad] Endereço:OraSure Technologies, Research and Development, Bethlehem, PA, USA.
[Ti] Título:Barbiturate detection in oral fluid, plasma, and urine.
[So] Source:Ther Drug Monit;33(1):72-9, 2011 Feb.
[Is] ISSN:1536-3694
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although current abuse of barbiturates is low compared with other classes of abused drugs, their narrow margin of safety, risk of dependence, and abuse liability remain a health concern. Limited information is available on the disposition of barbiturates in different biologic matrices. OBJECTIVE: The authors conducted a clinical study of the disposition of barbiturates in oral fluid, plasma, and urine after single-dose administration to healthy subjects. METHODS: Three parallel groups of 15 subjects were administered a single oral dose of one barbiturate: butalbital (50 mg), Phenobarbital (30 mg), or sodium secobarbital (100 mg). Subjects remained at the clinic for two confinement periods; the first was -1 to 36 hours postdose and again at 48 to 52 hours. Oral fluid specimens were collected by bilateral collection (Intercept; one on each side of the mouth simultaneously). Blood specimens were obtained by venipuncture and urine specimens were collected through separate collection pools of varying periods. Oral fluid specimens were analyzed for barbiturates by liquid chromatography-tandem mass spectroscopy with a limit of quantitation of 8 ng/mL. Plasma and urine specimens were analyzed by gas chromatography-mass spectroscopy with a limit of quantitation of 100 ng/mL. RESULTS: Barbiturate side effects included dizziness, drowsiness, and somnolence. All effects resolved spontaneously without medical intervention. The three barbiturates were detectable in oral fluid and plasma within 15 to 60 minutes of administration and in the first urine pooled collection at 2 hours. Butalbital and Phenobarbital remained detectable in all specimens through 48 to 52 hours, whereas secobarbital was frequently negative in the last collection. Oral fluid to plasma ratios appeared stable over the 1- to 48-hour collection period. CONCLUSION: This study demonstrated that single, oral therapeutic doses of butalbital, Phenobarbital, and secobarbital were excreted in readily detectable concentrations in oral fluid over a period of approximately 2 days. Oral fluid patterns of appearance and elimination were similar to that observed for plasma and urine.
[Mh] Termos MeSH primário: Barbitúricos/análise
Líquidos Corporais/química
Detecção do Abuso de Substâncias
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Barbitúricos/administração & dosagem
Barbitúricos/sangue
Barbitúricos/urina
Feminino
Seres Humanos
Masculino
Meia-Idade
Boca
Fenobarbital/administração & dosagem
Fenobarbital/análise
Fenobarbital/sangue
Fenobarbital/urina
Secobarbital/análise
Secobarbital/sangue
Secobarbital/urina
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Barbiturates); 1P7H87IN75 (Secobarbital); KHS0AZ4JVK (butalbital); YQE403BP4D (Phenobarbital)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101125
[St] Status:MEDLINE
[do] DOI:10.1097/FTD.0b013e3182018151


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[PMID]:20854063
[Au] Autor:Yamaguchi T; Shojima M; Delashaw JB; Watanabe E
[Ad] Endereço:Department of Neurosurgery, Jichi Medical University, Shimotsuke, Tochigi, Japan. takashiy@jichi.ac.jp
[Ti] Título:Wada test using secobarbital sodium (Ional) to determine language dominance.
[So] Source:Br J Neurosurg;25(2):203-9, 2011 Apr.
[Is] ISSN:1360-046X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The intracarotid sodium amobarbital (Amytal) test, the Wada test, remains an efficient test for evaluation of language and memory function. However, due to a world shortage of amobarbital, it has become necessary to investigate the use of alternatives. We report the efficacy of the Wada test using secobarbital sodium (Ional) in determining language dominance. An accurate determination of language dominance was required in 43 patients preoperatively at our institution. Patients underwent the Wada test using secobarbital sodium, effectiveness and safety were assessed. Patients were monitored for vital signs (blood pressure, respiratory rates, heart rates and saturation of oxygen). Ten patients were further monitored for continuous intra-arterial blood pressure and monitored with scalp electroencephalography (EEG). Language dominance was determined by the Wada test with secobarbital sodium in all patients. Total volume of secobarbital sodium injected was 10-25 mg (mean 16.5 ± 3.2 mg). Changes in vital signs were minimal and any induced neurological deficits completely disappeared within 8 min. On EEG records, induced theta waves immediately appeared on the ipsilateral side of the intra-arterial injection and disappeared within 6 min. One patient described a scintillating scotoma (sensation of shimmering light in his eyes) at the moment of injection; another experienced an epileptic episode during the test and recovered after 6 min. No adverse events were observed in the remaining 41 cases. We propose secobarbital sodium as a safe and reliable alternative to sodium amobarbital used in the Wada test to determine language dominance.
[Mh] Termos MeSH primário: Transtornos Cerebrovasculares/fisiopatologia
Dominância Cerebral/fisiologia
Epilepsia/fisiopatologia
Lateralidade Funcional/fisiologia
Hipnóticos e Sedativos
Secobarbital
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Eletroencefalografia
Feminino
Seres Humanos
Injeções Intra-Arteriais
Masculino
Memória/fisiologia
Meia-Idade
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); 1P7H87IN75 (Secobarbital)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100922
[St] Status:MEDLINE
[do] DOI:10.3109/02688697.2010.515319


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[PMID]:20825791
[Au] Autor:Gerhardt RT; Hermstad E; Crawford DM; Rayfield J; Pfaff J; Hunter CJ
[Ad] Endereço:U.S. Army Institute of Surgical Research, Fort Sam Houston, TX, USA. robert.gerhardt@amedd.army.mil
[Ti] Título:Postdischarge secobarbital after ED migraine treatment decreases pain and improves resolution.
[So] Source:Am J Emerg Med;29(1):86-90, 2011 Jan.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of the study was to determine whether the addition of postdischarge oral secobarbital to standard emergency department (ED) migraine headache therapy improves pain relief and headache resolution compared with placebo. SETTING: The setting is an urban ED with 70 000 yearly visits. METHODS: This is an Institutional Review Board-approved, randomized, nonconsecutive, double-blinded, concealed, and placebo-controlled clinical trial. Patients with a clinical diagnosis of migraine underwent standard ED treatment and were discharged with 2 tablets of either secobarbital 100 mg or placebo. At home arrival, subjects recorded headache pain on a visual analog scale (VAS), took 1 tablet, and went to bed, taking the second tablet after 1 hour if not asleep. Upon awakening, subjects completed a second VAS and survey. STATISTICAL ANALYSIS: The VAS data were analyzed using 2-tailed t test with unequal variance. Headache resolution data were analyzed using Fisher exact test. RESULTS: Fifty subjects were enrolled. Complete data and follow-up were available for 30 subjects (60%). Fourteen subjects received placebo; 16 received secobarbital. Secobarbital subjects reported an average headache pain decrease of 25 mm (-13 to -38) compared with an average increase of 3 mm (-13 to 19) in the placebo group (P = .01). Ninety-four percent of the secobarbital group vs 50% of the placebo group had complete or partial headache resolution (P < .02). All subjects in the secobarbital group reported some relief. CONCLUSIONS: Addition of postdischarge oral secobarbital to a standard ED migraine treatment regimen decreased headache pain at 24 hours after discharge and improved the rate of headache resolution compared with placebo.
[Mh] Termos MeSH primário: Transtornos de Enxaqueca/tratamento farmacológico
Secobarbital/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Serviço Hospitalar de Emergência
Feminino
Seres Humanos
Hipnóticos e Sedativos/administração & dosagem
Hipnóticos e Sedativos/uso terapêutico
Masculino
Meia-Idade
Dor/tratamento farmacológico
Medição da Dor
Alta do Paciente
Secobarbital/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); 1P7H87IN75 (Secobarbital)
[Em] Mês de entrada:1101
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100910
[St] Status:MEDLINE
[do] DOI:10.1016/j.ajem.2009.09.027


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[PMID]:20675629
[Au] Autor:Hewitt S; Williamson S; Woodger N; Streete P; Cracknell J; Lewis J
[Ad] Endereço:Paignton Zoo Environmental Park, Totnes Road, Paignton, Devon TQ4 7EU. sarahhewittvet@googlemail.com
[Ti] Título:Secobarbital poisoning in an Amur tiger (Panthera tigris altaica).
[So] Source:Vet Rec;167(5):178-80, 2010 Jul 31.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Animais de Zoológico
Ataxia/veterinária
Carne/envenenamento
Secobarbital/envenenamento
Tigres
[Mh] Termos MeSH secundário: Animais
Ataxia/induzido quimicamente
Eutanásia Animal/métodos
Feminino
Contaminação de Alimentos
Cavalos
Tempo de Reação
Secobarbital/isolamento & purificação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
1P7H87IN75 (Secobarbital)
[Em] Mês de entrada:1009
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100803
[St] Status:MEDLINE
[do] DOI:10.1136/vr.c3609



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