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[PMID]: 28901888 [Au] Autor: Tzang BS; Liu CH; Hsu KC; Chen YH; Huang CY; Hsu TC [Ad] Endereço: 1Institute of Biochemistry, Microbiology and Immunology,Chung Shan Medical University,Taichung 402,Taiwan,ROC. [Ti] Título: Effects of oral Lactobacillus administration on antioxidant activities and CD4+CD25+forkhead box P3 (FoxP3)+ T cells in NZB/W F1 mice. [So] Source: Br J Nutr;118(5):333-342, 2017 Sep. [Is] ISSN: 1475-2662 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterised by a dysregulation of the immune system, which causes inflammation responses, excessive oxidative stress and a reduction in the number of cluster of differentiation (CD)4+CD25+forkhead box P3 (FoxP3)+ T cells. Supplementation with certain Lactobacillus strains has been suggested to be beneficial in the comprehensive treatment of SLE. However, little is known about the effect and mechanism of certain Lactobacillus strains on SLE. To investigate the effects of Lactobacillus on SLE, NZB/W F1 mice were orally gavaged with Lactobacillus paracasei GMNL-32 (GMNL-32), Lactobacillus reuteri GMNL-89 (GMNL-89) and L. reuteri GMNL-263 (GMNL-263). Supplementation with GMNL-32, GMNL-89 and GMNL-263 significantly increased antioxidant activity, reduced IL-6 and TNF-α levels and significantly decreased the toll-like receptors/myeloid differentiation primary response gene 88 signalling in NZB/W F1 mice. Notably, supplementation with GMNL-263, but not GMNL-32 and GMNL-89, in NZB/W F1 mice significantly increased the differentiation of CD4+CD25+FoxP3+ T cells. These findings reveal beneficial effects of GMNL-32, GMNL-89 and GMNL-263 on NZB/W F1 mice and suggest that these specific Lactobacillus strains can be used as part of a comprehensive treatment of SLE patients. [Mh] Termos MeSH primário: Antioxidantes/metabolismo Linfócitos T CD4-Positivos/citologia Lactobacillus Probióticos/administração & dosagem [Mh] Termos MeSH secundário: Administração Oral Animais Linfócitos T CD4-Positivos/metabolismo Modelos Animais de Doenças Feminino Fatores de Transcrição Forkhead/metabolismo Glutationa/sangue Subunidade alfa de Receptor de Interleucina-2/metabolismo Interleucina-6/sangue Lactobacillus/classificação Lúpus Eritematoso Sistêmico/terapia Camundongos Camundongos Endogâmicos NZB RNA Mensageiro/sangue Tiobarbitúricos/sangue Receptores Toll-Like/sangue Fator de Necrose Tumoral alfa/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Forkhead Transcription Factors); 0 (Foxp3 protein, mouse); 0 (Il2ra protein, mouse); 0 (Interleukin-2 Receptor alpha Subunit); 0 (Interleukin-6); 0 (RNA, Messenger); 0 (Thiobarbiturates); 0 (Toll-Like Receptors); 0 (Tumor Necrosis Factor-alpha); GAN16C9B8O (Glutathione); M1YZW5SS7C (thiobarbituric acid) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170921 [Lr] Data última revisão: 170921 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170914 [St] Status: MEDLINE [do] DOI: 10.1017/S0007114517002112

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[PMID]: 28403345 [Au] Autor: Brito MV; Yasojima EY; Percário S; Ribeiro RF; Cavalcante LC; Monteiro AM; Couteiro RP; Rodrigues IA; Santos HA [Ad] Endereço: PhD, Full Professor, Department of Experimental Surgery, Universidade Estadual do Pará (UEPA), Belém-PA, Brazil. Conception, design and scientific content of the study, critical revision. [Ti] Título: Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats. [So] Source: Acta Cir Bras;32(3):211-218, 2017 Mar. [Is] ISSN: 1678-2674 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: Purpose: : To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in renal ischemia/reperfusion injury in rats. Methods: : Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. After reperfusion, blood samples were collected for BUN and creatinine serum levels analyzes. TBARS were evaluated in plasma and renal tissue to assess oxidative stress. Kidney histopathological examination were performed. Results: : Per+HSS group showed a lower degree of renal dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly reduced oxidative stress and histological damage. Conclusion: : Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute renal injury induced by ischemia/reperfusion. [Mh] Termos MeSH primário: Isquemia/prevenção & controle Precondicionamento Isquêmico/métodos Rim/irrigação sanguínea Substâncias Protetoras/farmacologia Traumatismo por Reperfusão/prevenção & controle Solução Salina Hipertônica/farmacologia [Mh] Termos MeSH secundário: Animais Nitrogênio da Ureia Sanguínea Creatinina/sangue Rim/química Rim/patologia Rim/fisiopatologia Testes de Função Renal Masculino Necrose Estresse Oxidativo Distribuição Aleatória Ratos Wistar Reprodutibilidade dos Testes Tiobarbitúricos/análise Fatores de Tempo Resultado do Tratamento [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Protective Agents); 0 (Saline Solution, Hypertonic); 0 (Thiobarbiturates); AYI8EX34EU (Creatinine); M1YZW5SS7C (thiobarbituric acid) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170831 [Lr] Data última revisão: 170831 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170414 [St] Status: MEDLINE

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[PMID]: 28341056 [Au] Autor: Prior SL; Barry JD; Caplin S; Min T; Grant DA; Stephens JW [Ad] Endereço: Diabetes Research Group, Medical School, Swansea University, Swansea, United Kingdom. [Ti] Título: Temporal changes in plasma markers of oxidative stress following laparoscopic sleeve gastrectomy in subjects with impaired glucose regulation. [So] Source: Surg Obes Relat Dis;13(2):162-168, 2017 Feb. [Is] ISSN: 1878-7533 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for obesity and associated metabolic complications. Obesity and type 2 diabetes are associated with increased oxidative stress. Previous studies have examined changes in plasma oxidative stress after laparoscopic Roux-en-Y gastric bypass, but there is limited evidence of the effects of LSG. OBJECTIVES: To examine the effects of LSG on plasma thiobarbituric acid reactive substances (TBARS) and total antioxidant status (TAOS) at 1 and 6 months after LSG in patients with obesity and impaired glucose regulation. SETTING: University hospital, United Kingdom. METHODS: Twenty-two participants with impaired glucose homeostasis undergoing LSG (body mass index 50.1 kg/m , glycated hemoglobin 53 mmol/mol) were studied. Measurements of fasting and 120-minute TBARS and TAOS were performed during an oral glucose tolerance test preoperatively and postoperatively. RESULTS: Compared with preoperative levels, significant decreases were seen 6 months postoperatively in fasting TBARS (61.0±17.9 versus 39.4±13.8 ng/mL, P = .04) and 120-minute TBARS (76.0±29.5 versus 46.5±16.3 ng/mL, P = .02). No significant changes were observed in plasma TAOS. No significant association was observed between changes in TBARS and other clinical or biochemical measures. CONCLUSION: We observed a significant reduction in TBARS, a global measure of lipid peroxidation 6 months after LSG in participants with obesity and impaired glucose regulation. [Mh] Termos MeSH primário: Antioxidantes/metabolismo Glicemia/metabolismo Gastrectomia/métodos Laparoscopia/métodos Estresse Oxidativo/fisiologia Tiobarbitúricos/metabolismo [Mh] Termos MeSH secundário: Adulto Biomarcadores/metabolismo Diabetes Mellitus Tipo 2/sangue Diabetes Mellitus Tipo 2/cirurgia Feminino Intolerância à Glucose/sangue Intolerância à Glucose/cirurgia Teste de Tolerância a Glucose Homeostase Seres Humanos Masculino Meia-Idade Obesidade Mórbida/cirurgia Cuidados Pós-Operatórios Estudos Prospectivos Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Nm] Nome de substância: 0 (Antioxidants); 0 (Biomarkers); 0 (Blood Glucose); 0 (Thiobarbiturates) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170905 [Lr] Data última revisão: 170905 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170326 [St] Status: MEDLINE

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[PMID]: 28185878 [Au] Autor: Janakiraman U; Manivasagam T; Justin Thenmozhi A; Dhanalakshmi C; Essa MM; Song BJ; Guillemin GJ [Ad] Endereço: Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608002, Tamilnadu, India. [Ti] Título: Chronic mild stress augments MPTP induced neurotoxicity in a murine model of Parkinson's disease. [So] Source: Physiol Behav;173:132-143, 2017 May 01. [Is] ISSN: 1873-507X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Depression is frequently encountered during Parkinson's disease (PD) as a non-motor feature, which has been reported to cause and exaggerate motor deficits and neurodegenerative events in experimental PD models. We studied the effect of chronic mild stress (CMS) (pre, post and pre & post) exposure mediated depression on motor and non-motor symptoms, oxidative stress, inflammation and brain derived neurotrophic factor (BDNF) levels and its related signalling molecules against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p) induced neurotoxicity in mice. CMS and MPTP/p-coexposed C57BL/6 mice exhibited low neuromuscular strength and stride length with enhanced oxidative stress and inflammation as compared to CMS or MPTP/p alone exposed mice. Coexposure diminished the levels of BDNF and expressions of p-TrkB, p-ERK/ERK, p-AKT/AKT and p-CREB in nigrostriatal regions as compared to those of the alone exposure. CMS alone exposed mice showed more anxiety related behaviour with diminished expression of serotonin transporter as compared to MPTP/p alone injected group. Post-stress exposure to MPTP/p mice exhibited lowest motor and reflecting higher anxiety state with greatest enhancement in inflammation and reduction in the protein expression of stress and cell signalling markers as compared to pre and pre & post stress exposed PD mice. However, pre- and pre & post CMS exposed PD animals are more vulnerable to oxidative stress as compared with post-stress experienced MPTP/p mice. CMS mediated depression exacerbates motor/non-motor symptoms in MPTP/p-PD animals by modulating oxidative stress and various signalling molecules. Our results suggested that stress induced NMS can accelerate neurodegenerative processes in the PD in a progressive or expedited manner. [Mh] Termos MeSH primário: 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina/efeitos adversos Transtornos Parkinsonianos/fisiopatologia Estresse Psicológico/fisiopatologia [Mh] Termos MeSH secundário: Adjuvantes Farmacêuticos/toxicidade Animais Peso Corporal/efeitos dos fármacos Fator Neurotrófico Derivado do Encéfalo/metabolismo Proteínas de Ligação ao Cálcio/metabolismo Catalase/metabolismo Modelos Animais de Doenças Comportamento Exploratório/efeitos dos fármacos Proteína Glial Fibrilar Ácida/metabolismo Masculino Aprendizagem em Labirinto/efeitos dos fármacos Camundongos Camundongos Endogâmicos C57BL Proteínas dos Microfilamentos/metabolismo Força Muscular/efeitos dos fármacos Probenecid/toxicidade Transdução de Sinais/efeitos dos fármacos Superóxido Dismutase/metabolismo Tiobarbitúricos/toxicidade Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Adjuvants, Pharmaceutic); 0 (Aif1 protein, rat); 0 (Brain-Derived Neurotrophic Factor); 0 (Calcium-Binding Proteins); 0 (Glial Fibrillary Acidic Protein); 0 (Microfilament Proteins); 0 (Thiobarbiturates); 0 (Thiobarbituric Acid Reactive Substances); 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); M1YZW5SS7C (thiobarbituric acid); PO572Z7917 (Probenecid) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170630 [Lr] Data última revisão: 170630 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170211 [St] Status: MEDLINE

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[PMID]: 27013186 [Au] Autor: Li Y; Yang Z; Li J [Ad] Endereço: College of Food Science and Technology, Bohai University, Food Safety Key Laboratory of Liaoning Province, National & Local Joint Engineering Research Centre for Storage, Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products, Jinzhou 121013, China. [Ti] Título: Shelf-life extension of Pacific white shrimp using algae extracts during refrigerated storage. [So] Source: J Sci Food Agric;97(1):291-298, 2017 Jan. [Is] ISSN: 1097-0010 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Shrimp is a low-fat, high-protein aquatic product, and is susceptible to spoilage during storage. To establish an effective method for the quality control of Pacific white shrimp, the effects of polyphenols (PP) and polysaccharides (PS) from Porphyra yezoensis on the quality of Pacific white shrimp were assessed during refrigerated storage. Pacific white shrimp samples were treated with 5 g L polyphenols, and 8 g L polysaccharides, then stored at 4 ± 1 °C for 8 days. All samples were subjected to measurement of total viable count (TVC), pH, total volatile basic nitrogen (TVB-N), K-value, thiobarbituric acid (TBA), polyphenol oxidase (PPO) activity, and were also assessed by sensory evaluation. RESULTS: The results showed that PP, PS, and the mixture of polyphenols and polysaccharides (PP+PS) could inhibit the increase of total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA) and K-value, and reduce total viable count (TVC) compared with the control group. PP could also inhibit polyphenol oxidase (PPO) activity. Sensory evaluation proved the efficacy of PP and PS by maintaining the overall quality of Pacific white shrimp during refrigerated storage. Moreover, PP+PS could extend the shelf-life of shrimp by 3-4 days compared with the control group. CONCLUSION: PP+PS could more effectively maintain quality and extend shelf-life during refrigerated storage. © 2016 Society of Chemical Industry. [Mh] Termos MeSH primário: Conservação de Alimentos/métodos Penaeidae Polifenóis/administração & dosagem Polissacarídeos/administração & dosagem Porphyra/química Frutos do Mar [Mh] Termos MeSH secundário: Animais Catecol Oxidase/antagonistas & inibidores Temperatura Baixa Nitrogênio/análise Controle de Qualidade Tiobarbitúricos/análise Fatores de Tempo Volatilização [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Polyphenols); 0 (Polysaccharides); 0 (Thiobarbiturates); EC 1.10.3.1 (Catechol Oxidase); M1YZW5SS7C (thiobarbituric acid); N762921K75 (Nitrogen) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170808 [Lr] Data última revisão: 170808 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160326 [St] Status: MEDLINE [do] DOI: 10.1002/jsfa.7730

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[PMID]: 25521238 [Au] Autor: Hicyilmaz H; Vural H; Delibas N; Sutcu R; Gultekin F; Yilmaz N [Ad] Endereço: a Burdur State Hospital , Turkey. [Ti] Título: The effects of walnut supplementation on hippocampal NMDA receptor subunits NR2A and NR2B of rats. [So] Source: Nutr Neurosci;20(3):203-208, 2017 Apr. [Is] ISSN: 1476-8305 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVES: Walnuts contain numerous selected dietary factors that have an impact on brain functions, especially learning and memory formation in the hippocampus. Hippocampal N-methyl d-aspartate receptors (NMDARs) are involved in the formation of cognitive functions. In this study, we aimed to investigate the molecular effects of walnut supplementation on the hippocampal expressions of NMDARs involved in cognitive functions and lipid peroxidation levels in rats. METHODS: The male Sprague-Dawley rats (6 months old, n = 24) were fed with a walnut-supplemented diet (6% walnut diet, n = 12) and a control diet (rat food, n = 12) as ad libitum for 8 weeks. At the end of this period, NMDAR subunits NR2A and NR2B in the hippocampi were assayed by western blotting. Lipid peroxidation levels were measured using the thiobarbituric acid. RESULTS: The expression of NR2A and NR2B was elevated in the walnut-supplemented rats compared with the control group (P < 0.05). In addition, the levels of lipid peroxidation in the walnut-supplemented group were significantly decreased compared with the control group. DISCUSSION: We suggested that walnut supplementation may have protective effects against the decline of cognitive functions by regulating NMDAR and lipid peroxidation levels in the hippocampus. The study provides evidence that selected dietary factors (polyunsaturated fatty acids, melatonin, vitamin E, and flavonoids) within walnut may help to trigger hippocampal neuronal signal transduction for the formation of learning and memory. [Mh] Termos MeSH primário: Alimento Funcional Hipocampo/metabolismo Juglans Nozes Receptores de N-Metil-D-Aspartato/metabolismo Regulação para Cima [Mh] Termos MeSH secundário: Animais Biomarcadores/metabolismo Western Blotting Disfunção Cognitiva/prevenção & controle Regulação para Baixo Peroxidação de Lipídeos Masculino Proteínas do Tecido Nervoso/metabolismo Neurônios/metabolismo Neuroproteção Distribuição Aleatória Ratos Sprague-Dawley Tiobarbitúricos/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (NR2A NMDA receptor); 0 (NR2B NMDA receptor); 0 (Nerve Tissue Proteins); 0 (Receptors, N-Methyl-D-Aspartate); 0 (Thiobarbiturates); M1YZW5SS7C (thiobarbituric acid) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141219 [St] Status: MEDLINE [do] DOI: 10.1179/1476830514Y.0000000166

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[PMID]: 27765409 [Au] Autor: Hron RJ; Jursic BS; Neumann DM [Ad] Endereço: Department of Chemistry, University of New Orleans, New Orleans, LA 70148, United States. [Ti] Título: Synthesis of N-aryl and N-arylcarbamoylamino derivatives of 1,3-diazinane-5-carboxamide and their activity against glioblastoma LN-229 cell line. [So] Source: Bioorg Med Chem;24(23):6183-6193, 2016 Dec 01. [Is] ISSN: 1464-3391 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Six structural motifs based on the initial (lead) structure of merbarone were designed, prepared, and tested against the glioblastoma LN-229 cell line. Three different structural moieties were modified in the search for optimal glioblastoma activity: the 1,3-diazinane moiety, the aryl moiety, and the heteroatom linker. Calculated molecular descriptors such as lipophilicity (ClogP), acidic strength (calculated pK ), and polar surface area (PSA) were used to design a diverse structural library of these compounds. From six different structural motifs and 136 compounds, a handful of examples with moderate (100µg/ml), good (10µg/ml) and excellent (1µg/ml) glioblastoma activity were elucidated. [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Barbitúricos/farmacologia Compostos de Fenilureia/farmacologia Inibidores da Topoisomerase II/farmacologia [Mh] Termos MeSH secundário: Antineoplásicos/síntese química Antineoplásicos/química Barbitúricos/síntese química Barbitúricos/química Carbamatos/química Linhagem Celular Tumoral Ensaios de Seleção de Medicamentos Antitumorais Glioblastoma Seres Humanos Compostos de Fenilureia/síntese química Compostos de Fenilureia/química Tiobarbitúricos/química Inibidores da Topoisomerase II/síntese química Inibidores da Topoisomerase II/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Barbiturates); 0 (Carbamates); 0 (Phenylurea Compounds); 0 (Thiobarbiturates); 0 (Topoisomerase II Inhibitors); YWB9IF596V (merbarone) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161022 [St] Status: MEDLINE

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[PMID]: 27735850 [Au] Autor: Elshaier YA; Barakat A; Al-Qahtany BM; Al-Majid AM; Al-Agamy MH [Ad] Endereço: Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assuit 71524, Egypt. yaseenorganic@yahoo.com. [Ti] Título: Synthesis of Pyrazole-Thiobarbituric Acid Derivatives: Antimicrobial Activity and Docking Studies. [So] Source: Molecules;21(10), 2016 Oct 09. [Is] ISSN: 1420-3049 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: A one-pot reaction was described that results in various pyrazole-thiobarbituric acid derivatives as new pharmacophore agents. These new heterocycles were synthesized in high yields with a broad substrate scope under mild reaction conditions in water mediated by NHEt2. The molecular structures of the synthesized compounds were assigned based on different spectroscopic techniques. The new compounds were evaluated for their antibacterial and antifungal activity. Compounds and were the most active compounds against with MIC = 4 µg/L. Compound exhibited the best activity against and with MIC = 16 µg/L. However, compounds and were the most active against with MIC = 16 µg/L. Molecular docking studies for the final compounds and standard drugs were performed using the OpenEye program. [Mh] Termos MeSH primário: Antibacterianos/síntese química Antifúngicos/síntese química Pirazóis/síntese química Tiobarbitúricos/síntese química [Mh] Termos MeSH secundário: Antibacterianos/química Antibacterianos/farmacologia Antifúngicos/química Antifúngicos/farmacologia Candida albicans/efeitos dos fármacos Candida albicans/patogenicidade Seres Humanos Testes de Sensibilidade Microbiana Simulação de Acoplamento Molecular Pirazóis/química Pirazóis/farmacologia Staphylococcus aureus/efeitos dos fármacos Staphylococcus aureus/patogenicidade Tiobarbitúricos/química Tiobarbitúricos/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Pyrazoles); 0 (Thiobarbiturates); 3QD5KJZ7ZJ (pyrazole); M1YZW5SS7C (thiobarbituric acid) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170411 [Lr] Data última revisão: 170411 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161014 [St] Status: MEDLINE

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[PMID]: 27667475 [Au] Autor: Azizi S; Shahrisa A; Khoubnasabjafari M; Ansarin K; Khoubnasabjafari M; Soleymani J; Jouyban A [Ad] Endereço: Pharmaceutical Analysis Research Center & Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran. [Ti] Título: A possible reason for the low reproducibility of malondialdehyde determinations in biological samples. [So] Source: Bioanalysis;8(21):2179-2181, 2016 Nov. [Is] ISSN: 1757-6199 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão Malondialdeído/análise [Mh] Termos MeSH secundário: Biomarcadores/análise Biomarcadores/sangue Seres Humanos Malondialdeído/sangue Malondialdeído/química Estresse Oxidativo Reprodutibilidade dos Testes Tiobarbitúricos/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Thiobarbiturates); 4Y8F71G49Q (Malondialdehyde); M1YZW5SS7C (thiobarbituric acid) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170112 [Lr] Data última revisão: 170112 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160927 [St] Status: MEDLINE

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[PMID]: 27411075 [Au] Autor: Usinger EL; Larson EM; Niebuhr SE; Fedler CA; Prusa KJ; Dickson JS; Tarté R; Sebranek JG [Ad] Endereço: Department of Animal Science, Iowa State University, Ames, IA 50011, United States. [Ti] Título: Can supplemental nitrate in cured meats be used as a means of increasing residual and dietary nitrate and subsequent potential for physiological nitric oxide without affecting product properties? [So] Source: Meat Sci;121:324-32, 2016 Nov. [Is] ISSN: 1873-4138 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The effects of formulated sodium nitrate plus supplemental nitrate (SN) from celery juice powder on residual nitrite, residual nitrate, rancidity, microbial growth, color, sensory properties, and proximate composition of frankfurters, cotto salami and boneless ham during storage (1°C) were studied. The products were assigned one of two treatments, which were each replicated twice: control (156ppm sodium nitrite) or SN (156ppm sodium nitrite and 1718ppm sodium nitrate in combination with 2% VegStable 502). Sensory parameters and proximate composition were measured once for each replication. All other analytical measurements were conducted at regular intervals for 97-98days. The SN showed no increase in residual nitrite compared to the control. No changes (P>0.05) were observed in residual nitrate during storage for any of the products. The results showed that addition of SN did not significantly alter most physical, chemical or microbial properties of cured meat products during refrigerated storage, but some product dependent sensory effects were observed. [Mh] Termos MeSH primário: Produtos da Carne/análise Nitratos/análise Óxido Nítrico/análise [Mh] Termos MeSH secundário: Animais Apium graveolens/química Contagem de Colônia Microbiana Cor Comportamento do Consumidor Segurança de Produtos ao Consumidor Gorduras na Dieta/análise Proteínas na Dieta/análise Contaminação de Alimentos Manipulação de Alimentos Microbiologia de Alimentos Sucos de Frutas e Vegetais/análise Seres Humanos Lactobacillus/isolamento & purificação Produtos da Carne/microbiologia Nitritos/análise Nitrito de Sódio Suínos Paladar Tiobarbitúricos/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Dietary Fats); 0 (Dietary Proteins); 0 (Nitrates); 0 (Nitrites); 0 (Thiobarbiturates); 31C4KY9ESH (Nitric Oxide); 8M4L3H2ZVZ (sodium nitrate); M0KG633D4F (Sodium Nitrite); M1YZW5SS7C (thiobarbituric acid) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170602 [Lr] Data última revisão: 170602 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160714 [St] Status: MEDLINE

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