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Fotocópia
[PMID]:15582683
[Au] Autor:Morais LC; Quintans-Júnior LJ; Franco CI; Almeida JR; Almeida RN
[Ad] Endereço:Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, CP 5009, CEP 58051-970 João Pessoa, PB, Brazil. liana@ltf.ufpb.br
[Ti] Título:Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology.
[So] Source:Pharmacol Biochem Behav;79(4):745-9, 2004 Dec.
[Is] ISSN:0091-3057
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tremorine-induced tremors model is used to evaluate antiparkinsonian drugs because rest tremor is a sign that distinguishes Parkinson's disease (PD) from other diseases. The effects of crude ethanolic extract (CEE) and total acetate fraction (TAF) of Plumbago scandens were investigated at several doses. These extracts at doses of 125 and 250 mg/kg i.p. failed to reduce tremors in tremorine-treated mice. TAF showed significant effects only at a dose of 500 mg/kg. Both CEE and TAF at doses of 1000 and 2000 mg/kg i.p. suppressed the tremors in a dose-dependent fashion for 60 min. Biperiden, an anticholinergic drug, was used as standard at a dose of 3 mg/kg i.p. This study suggests that P. scandens is a plant with possible therapeutic value for PD.
[Mh] Termos MeSH primário: Antiparkinsonianos/uso terapêutico
Plumbaginaceae
Tremor/tratamento farmacológico
Tremorina/toxicidade
[Mh] Termos MeSH secundário: Animais
Antiparkinsonianos/isolamento & purificação
Masculino
Camundongos
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Estruturas Vegetais
Tremor/induzido quimicamente
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiparkinson Agents); 0 (Plant Extracts); U817VZ1URQ (Tremorine)
[Em] Mês de entrada:0504
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:041208
[St] Status:MEDLINE


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Fotocópia
[PMID]:11377760
[Au] Autor:Naik SR; Harindran J; Varde AB
[Ad] Endereço:Laboratory of Industrial Microbiology and Fermentation, Antibiotics Research Centre, Hindustan Antibiotics Limited, Pimpri, 411018, Pune, India. kmkcp@bom3.vsnl.net.in
[Ti] Título:Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity.
[So] Source:J Biotechnol;88(1):1-10, 2001 Jun 01.
[Is] ISSN:0168-1656
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pimprinine, an extracellular alkaloid has been isolated from the culture filtrate of Streptomyces CDRIL-312. Pimprinine was subsequently purified using silica gel column chromatography and also by preparatory thin layer chromatography. Some physicochemical properties, antimicrobial activities (in-vitro) and pharmacological activities of pimprinine were studied. Pimprinine showed promising anticonvulsant activity in both minimum and maximum electric seizure threshold test in mice. Its anticonvulsant activity is very much comparable to that of phenyl hydantion sodium. Pimprinine also inhibited effectively tremorine-induced tremors and analgesia in mice.
[Mh] Termos MeSH primário: Anticonvulsivantes/farmacologia
Oxazóis/metabolismo
Oxazóis/farmacologia
Fenitoína/metabolismo
Fenitoína/farmacologia
Streptomyces/metabolismo
[Mh] Termos MeSH secundário: Animais
Biotecnologia/métodos
Cromatografia em Camada Delgada/métodos
Relação Dose-Resposta a Droga
Fermentação
Dose Letal Mediana
Camundongos
Camundongos Endogâmicos
Testes de Sensibilidade Microbiana
Oxazóis/isolamento & purificação
Fenitoína/isolamento & purificação
Insuficiência Respiratória/induzido quimicamente
Convulsões/tratamento farmacológico
Testes de Toxicidade
Tremor/induzido quimicamente
Tremor/tratamento farmacológico
Tremorina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Oxazoles); 13640-26-1 (pimprinine); 6158TKW0C5 (Phenytoin); U817VZ1URQ (Tremorine)
[Em] Mês de entrada:0109
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010530
[St] Status:MEDLINE


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[PMID]:9303245
[Au] Autor:Young CW; Young MS; Lin MT
[Ad] Endereço:Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan, ROC.
[Ti] Título:Ultrasonic analysis of tremorine and cold tremor activity in unanesthetized rats.
[So] Source:Chin J Physiol;40(2):85-90, 1997 Jun 30.
[Is] ISSN:0304-4920
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:eng
[Ab] Resumo:In order to quantify the tremorine and cold tremor activity in unanesthetized rats, a new ultrasonic motion transducer method was used. Both kinds of activity are reported as vibratory body motion that occurred between 18-32 Hz as determined by spectral analysis. The recorded signal was analyzed and its power spectrum was obtained through a fast Fourier transform operation. It was found that a negative linear relation occurs between shiver amplitude and ambient temperature (r = 0.999). A negative linear relation also occurs between metabolic rate and ambient temperature (r = 0.997). In addition, a positive linear relation between metabolic rate and cold shiver exists (r = 0.999). Both tremorine (30 mg/kg, i.p.) and cold tremor (Ta = 2-22 degrees C) activity monitored by the ultrasonic method were completely abolished by premedication with 1 mg/kg atropine. Thus, it appears that the advantages of this tremor detection method are that is non-invasive and non-contact. Therefore, the ultrasonic method provides a good choice for quantifying tremorine and cold tremor activity in unanesthetized animals during studies of thermoregulatory physiology or motor disorders.
[Mh] Termos MeSH primário: Temperatura Baixa
Tremor por Sensação de Frio/fisiologia
Tremorina/toxicidade
Ultrassom
[Mh] Termos MeSH secundário: Animais
Regulação da Temperatura Corporal/efeitos dos fármacos
Análise de Fourier
Masculino
Consumo de Oxigênio/fisiologia
Ratos
Ratos Sprague-Dawley
Tremor por Sensação de Frio/efeitos dos fármacos
Transdutores
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
U817VZ1URQ (Tremorine)
[Em] Mês de entrada:9710
[Cu] Atualização por classe:150901
[Lr] Data última revisão:
150901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970630
[St] Status:MEDLINE


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Fotocópia
[PMID]:9074897
[Au] Autor:Ali BH; Tanira MO; Bashir AK
[Ad] Endereço:Desert and Marine Environment Research Centre, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
[Ti] Título:The effect of furazolidone and furaltadone on drug metabolism in rats.
[So] Source:Eur J Drug Metab Pharmacokinet;21(4):327-32, 1996 Oct-Dec.
[Is] ISSN:0378-7966
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:This work examines the effect of oral treatment of rats with the nitrofuran drugs furazolidone (FZ) and furaltadone (F) at doses of 100, 200 and 400 mg/kg for 4 days, or F in the drinking water at concentrations of 0.1, 0.2 and 0.4% w/v for 14 days, on drug metabolism in vivo. FZ at doses of 200 and 400 mg/kg, and F at a dose of 400 mg/kg or at a concentration of 0.4% w/v in water depressed growth and prolonged pentobarbitone-induced sleeping time. Treatment also significantly increased the blood concentration of metronidazole when measured 30 and 40 min after metronidazole administration. Administration of tremorine (25 mg/kg, i.p.) to control vehicle-treated rats produced within 2-3 min tremors, piloerection, profuse salivation, defecation urination and chromodacryorrhesis (red tears). The onset of appearance of these signs was delayed to 7-12 min in rats pretreated with FZ or F (100 mg/kg, 4 days) or cimetidine (50 mg/kg, i.p.) given 45 min earlier. Taken together, these results suggest that FZ and F inhibit drug metabolism in rats. Treatment with these nitrofuran drugs may alter the disposition of certain drugs which may be given concomitantly with them.
[Mh] Termos MeSH primário: Anti-Infecciosos Urinários/farmacologia
Furazolidona/farmacologia
Nitrofuranos/farmacologia
Oxazolidinonas
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Interações Medicamentosas
Masculino
Metronidazol/administração & dosagem
Metronidazol/sangue
Tamanho do Órgão/efeitos dos fármacos
Pentobarbital/administração & dosagem
Pentobarbital/metabolismo
Ratos
Ratos Wistar
Sono
Testículo/efeitos dos fármacos
Fatores de Tempo
Tremor/induzido quimicamente
Tremorina/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Urinary); 0 (Nitrofurans); 0 (Oxazolidinones); 140QMO216E (Metronidazole); 5J9CPU3RE0 (Furazolidone); 5X4V82ZN30 (furaltadon); I4744080IR (Pentobarbital); U817VZ1URQ (Tremorine)
[Em] Mês de entrada:9706
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:961001
[St] Status:MEDLINE


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Fotocópia
[PMID]:7813990
[Au] Autor:Sharif SI; Ali BH
[Ad] Endereço:Department of Pharmacology, Faculty of Medicine, Al Arab Medical University, Benghazi, Libya.
[Ti] Título:Effect of grapefruit juice on drug metabolism in rats.
[So] Source:Food Chem Toxicol;32(12):1169-71, 1994 Dec.
[Is] ISSN:0278-6915
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of grapefruit juice on in vivo drug metabolism was investigated in rats. The juice (4 ml or 8 ml/kg) was given orally once daily for 2 consecutive days and its effect on theophylline metabolism, pentobarbitone sleeping time and the tremorgenic action of tremorine was studied. The effect of grapefruit juice on some of these parameters was compared with that of the known drug metabolism inhibitor cimetidine given ip. Grapefruit juice at 4 ml and 8 ml/kg produced significant increases in pentobarbitone sleeping time that reached 46 and 79%, respectively, compared with 107% produced by cimetidine (50 mg/kg, ip). The juice at 4 ml/kg also significantly increased plasma theophylline concentration when measured 15, 30, 60 and 90 min after ip theophylline administration (10 mg/kg). Thereafter, no significant differences were detected in plasma drug concentrations between juice- and saline-treated animals. Administration of tremorine (25 mg/kg, ip) to saline-treated controls produced, within 2 or 3 min, tremors, piloerection, profuse salivation, defaecation, urination and chromodacryorrhesis (red tears). The onset of appearance of these signs was delayed to about 7 min in rats pretreated 1 hr earlier with either grapefruit juice (4 ml/kg, orally) or cimetidine (50 mg/kg, ip). The severity of the above signs was markedly reduced to a similar extent in both the juice- and cimetidine-treated rats. These results suggest that grapefruit juice may act as an inhibitor of drug metabolism in rats, and that its consumption may alter the disposition of certain concomitantly administered drugs.
[Mh] Termos MeSH primário: Bebidas
Citrus
Interações Alimento-Droga
Pentobarbital/metabolismo
Teofilina/farmacocinética
Tremorina/metabolismo
[Mh] Termos MeSH secundário: Animais
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Oxotremorina/metabolismo
Pentobarbital/farmacologia
Ratos
Ratos Sprague-Dawley
Teofilina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
5RY0UWH1JL (Oxotremorine); C137DTR5RG (Theophylline); I4744080IR (Pentobarbital); U817VZ1URQ (Tremorine)
[Em] Mês de entrada:9502
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:941201
[St] Status:MEDLINE


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[PMID]:8220662
[Au] Autor:Szmigielska H; Szmigielski A; Szadowska A
[Ad] Endereço:Department of Pharmacodynamics, Medical Academy, Lódz, Poland.
[Ti] Título:The responsiveness of M2-muscarinic receptors in the posterior hypothalamus and brain stem of vasopressin hypertensive rats.
[So] Source:Pol J Pharmacol;45(3):291-8, 1993 May-Jun.
[Is] ISSN:1230-6002
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The response of an endogenous inhibitor of cAMP-dependent protein kinase (type I inhibitor) to tremorine was used as an index of sensitivity of control muscarinic M2-receptors. Tremorine induced a dose-dependent increase in type I inhibitor activity in the posterior hypothalamus and brain stem. The action of the compound was blocked by pretreatment with aminophylline and atropine. Prolonged, 28 days treatment with lysine vasopressin (1 U/kg/day ip) induced hypertension and modified the dose-response curve for tremorine. Five times higher doses of tremorine than in normotensive rats were necessary to induce statistically significant increase in type I inhibitor activity in the posterior hypothalamus and brain stem suggesting subsensitivity of M2-muscarinic receptors in the brain areas responsible for the regulation of blood pressure.
[Mh] Termos MeSH primário: Tronco Encefálico/metabolismo
Hipertensão/metabolismo
Hipotálamo Posterior/metabolismo
Receptores Muscarínicos/metabolismo
[Mh] Termos MeSH secundário: Aminofilina/farmacologia
Animais
Tronco Encefálico/efeitos dos fármacos
Relação Dose-Resposta a Droga
Hipertensão/induzido quimicamente
Hipotálamo Posterior/efeitos dos fármacos
Injeções Intraperitoneais
Lipressina
Masculino
Ratos
Ratos Wistar
Tremorina/antagonistas & inibidores
Tremorina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Muscarinic); 27Y3KJK423 (Aminophylline); 50-57-7 (Lypressin); U817VZ1URQ (Tremorine)
[Em] Mês de entrada:9312
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:930501
[St] Status:MEDLINE


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[PMID]:1930347
[Au] Autor:Yamamoto S; Takemori E; Hasegawa Y; Nakao K; Inukai T; Nomura M; Morino K; Tsuchiyama M; Hasegawa K; Ikeda H
[Ad] Endereço:Pre-clinical Research Department, Ciba-Geigy Limited, Takarazuka, Japan.
[Ti] Título:General pharmacology of the novel angiotensin converting enzyme inhibitor benazepril hydrochloride. Effects on central nervous and sensory systems and other functions.
[So] Source:Arzneimittelforschung;41(6):602-7, 1991 Jun.
[Is] ISSN:0004-4172
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The effects of benazepril hydrochloride (CGS 14824 A, CAS 86541-74-4), a novel angiotension I converting enzyme inhibitor, on the central nervous systems, were studied in experimental animals. Benazepril hydrochloride (3 or 10 mg/kg/d, p.o. for 14 days) dose-dependently inhibited the increase in the blood pressure caused by continuous norepinephrine (NE) infusion in spontaneously hypertensive rats (SHR) and suppressed in seizures induced by a monoamine oxidase inhibitor, tranylcypromine in NE infused SHR. Benazepril hydrochloride transiently increased spontaneous motor activity in mice, tended to inhibit acetic acid-induced writhing in mice and decreased fast wave sleep and slow wave deep sleep on EEG in cats at a high dose of 100 mg/kg p.o. However, benazepril hydrochloride at the same dose showed no effect on other central nervous and sensory systems in experimental animals.
[Mh] Termos MeSH primário: Inibidores da Enzima Conversora de Angiotensina/farmacologia
Benzazepinas/farmacologia
Sistema Nervoso Central/efeitos dos fármacos
Neurônios Aferentes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acetatos/antagonistas & inibidores
Ácido Acético
Animais
Anticonvulsivantes
Aprendizagem da Esquiva/efeitos dos fármacos
Temperatura Corporal/efeitos dos fármacos
Eletroencefalografia
Masculino
Metanfetamina/antagonistas & inibidores
Camundongos
Camundongos Endogâmicos
Atividade Motora/efeitos dos fármacos
Equilíbrio Postural/efeitos dos fármacos
Ratos
Ratos Endogâmicos SHR
Reflexo/efeitos dos fármacos
Reserpina/antagonistas & inibidores
Tranilcipromina/antagonistas & inibidores
Tremorina/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Anticonvulsants); 0 (Benzazepines); 3E3V44J4Z9 (Tranylcypromine); 44RAL3456C (Methamphetamine); 8B1QWR724A (Reserpine); Q40Q9N063P (Acetic Acid); U817VZ1URQ (Tremorine); UDM7Q7QWP8 (benazepril)
[Em] Mês de entrada:9111
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:910601
[St] Status:MEDLINE


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[PMID]:1833294
[Au] Autor:Nagase T; Hotta K; Morita S; Sakai K; Yamane M; Omote M; Mizusawa H
[Ad] Endereço:Marion Merrell Dow K.K., Development Laboratories, Osaka, Japan.
[Ti] Título:[Pharmacological effects of the novel dopamine uptake inhibitor 1-[2-[bis(4-fluorophenyl)-methoxy]ethyl]-4-(3-phenylpropyl) piperazine dihydrochloride (I-893) on the central nervous system].
[So] Source:Nihon Yakurigaku Zasshi;98(2):121-41, 1991 Aug.
[Is] ISSN:0015-5691
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The effects of 1-[2-[bis (4-fluorophenyl)methoxy]ethyl]-4-(3- phenylpropyl) piperazine dihydrochloride (I-893) on the central nervous system were behaviorally and electroencephalographically investigated. Intraperitoneally injected I-893 (5-10 mg/kg) dose-dependently increased spontaneous motor activity in mice, but repeated injections did not affect the increase in the locomotor activity. In reserpinized mice, spontaneous motor activity was not increased by oral I-893. In alpha-MPT-treated mice, the motor activity was lower than that in vehicle-treated animals with intermediate doses (10-40 mg/kg, p.o.) of I-893, but there was no difference between the two groups with high doses. In rats with unilaterally 6-OHDA-induced lesion of the nigrostriatal pathway, I-893 induced circling behavior toward the lesioned side. Haloperidol-induced catalepsy in rats was reduced by I-893. Tremorine-induced tremor in mice was inhibited by I-893. The effect was not altered in the mice treated with I-893 for 10 days. Oral I-893 induced stereotypy in rats, but it did not affect methamphetamine-induced stereotypy. Hypnosis induced by barbiturates was antagonized by I-893. In rats treated with I-893 for 6 days, pentobarbital-induced sleep was not different from that in vehicle-treated animals on the day after the final treatment. Intravenous I-893 altered EEGs in the cerebral cortex and amygdala nucleus to low voltage and fast waves and altered hippocampal EEG to theta waves in immobilized rabbits. These results suggest that I-893 inhibits re-uptake of dopamine released by exocytosis and indirectly has dopaminergic effects.
[Mh] Termos MeSH primário: Eletroencefalografia
Atividade Motora/efeitos dos fármacos
Inibidores da Captação de Neurotransmissores/farmacologia
Piperazinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Barbitúricos/antagonistas & inibidores
Temperatura Corporal/efeitos dos fármacos
Catalepsia
Cães
Dopamina/metabolismo
Relação Dose-Resposta a Droga
Haloperidol/antagonistas & inibidores
Levodopa/farmacologia
Masculino
Metanfetamina/antagonistas & inibidores
Camundongos
Coelhos
Ratos
Ratos Endogâmicos
Sono/efeitos dos fármacos
Tremor
Tremorina/antagonistas & inibidores
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Barbiturates); 0 (Neurotransmitter Uptake Inhibitors); 0 (Piperazines); 44RAL3456C (Methamphetamine); 46627O600J (Levodopa); 90X28IKH43 (vanoxerine); J6292F8L3D (Haloperidol); U817VZ1URQ (Tremorine); VTD58H1Z2X (Dopamine); WQ92Y2793G (barbituric acid)
[Em] Mês de entrada:9111
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:910801
[St] Status:MEDLINE


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Fotocópia
[PMID]:2370805
[Au] Autor:Sethy VH; Francis JW
[Ad] Endereço:CNS Disease Research, Upjohn Company, Kalamazoo, MI 49001.
[Ti] Título:Pharmacokinetics of muscarinic cholinergic drugs as determined by ex vivo (3H)-oxotremorine-M binding.
[So] Source:J Pharmacol Methods;23(4):285-96, 1990 Jul.
[Is] ISSN:0160-5402
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The pharmacokinetic parameters of muscarinic cholinergic drugs after intravenous (IV) and oral administration to mice was determined with ex vivo (3H)-oxotremorine-M (3H-Oxt) binding to the brain. Oxotremorine had a long duration of action, and arecoline had a short one. There was a significant correlation between the ex vivo ED50 and the in vitro inhibition constants (Ki). Tremorine, a prodrug, inhibited ex vivo binding, but was relatively inactive in in vitro binding. The quaternary amines, methylscopolamine and oxotremorine-M, and the hydrophilic compound, pirenzepine, were relatively weak in inhibiting ex vivo binding because of their poor penetration of the blood-brain barrier. Oxotremorine and BM-5 were similarly bioavailable to the brain by the IV and the oral route. These results indicate that the pharmacokinetic profile of muscarinic cholinergic drugs can be determined with ex vivo (3H)-Oxt binding.
[Mh] Termos MeSH primário: Oxotremorina/farmacocinética
Parassimpatomiméticos/farmacocinética
[Mh] Termos MeSH secundário: Animais
Ligação Competitiva/efeitos dos fármacos
Disponibilidade Biológica
Encéfalo/efeitos dos fármacos
Encéfalo/metabolismo
Injeções Intravenosas
Masculino
Camundongos
Oxotremorina/metabolismo
Pirenzepina/farmacologia
Ratos
Ratos Endogâmicos
Tremorina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parasympathomimetics); 3G0285N20N (Pirenzepine); 5RY0UWH1JL (Oxotremorine); U817VZ1URQ (Tremorine)
[Em] Mês de entrada:9008
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900701
[St] Status:MEDLINE


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Fotocópia
[PMID]:3401148
[Au] Autor:Hocking AD; Holds K; Tobin NF
[Ad] Endereço:CSIRO Division of Food Research, North Ryde, New South Wales.
[Ti] Título:Intoxication by tremorgenic mycotoxin (penitrem A) in a dog.
[So] Source:Aust Vet J;65(3):82-5, 1988 Mar.
[Is] ISSN:0005-0423
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 1-year-old Siberian Husky dog presented with severe muscle tremors after ingestion of a mouldy hamburger bun. Penicillium crustosum and the tremorgenic mycotoxin penitrem A were isolated from the remaining portion of the hamburger bun. When grown in pure culture, the isolate of P. crustosum produced large amounts of penitrem A, along with other penitrem compounds. This is the first reported Australian case of toxicosis by naturally occurring penitrem A.
[Mh] Termos MeSH primário: Doenças do Cão/induzido quimicamente
Tremor/veterinária
Tremorina/envenenamento
[Mh] Termos MeSH secundário: Animais
Pão/toxicidade
Cães
Penicillium/isolamento & purificação
Tremor/induzido quimicamente
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
U817VZ1URQ (Tremorine)
[Em] Mês de entrada:8809
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:880301
[St] Status:MEDLINE



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