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[PMID]:29328636
[Au] Autor:Komatina N; Lepic T; Labovic B; Stevovic T; Petronijevic M; Radovinovic-Tasic S; Obradovic D
[Ti] Título:Relapse of Takayasu arteritis as a cause of suicidal poisoning and subsequent major ischemic stroke successfully treated with thrombolytic therapy.
[So] Source:Vojnosanit Pregl;73(8):788-92, 2016 Aug.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: Takayasu arteritis (TA) is a rare large vessel arteritis, affecting primarily aorta and its major branches. Its clinical manifestations can vary significantly - from asymptomatic to serious vascular events. Acute neurological complications are frequent at the onset of the disease and in relapses. Anxiety and depression are more frequent in TA patients than in general population as well as during relapses. Prevalence of transient ischemic attack or ischemic stroke in TA patients is approximately 10-20%. Case report: We presented a patient with TA that began with a depressive episode resulting in attempted suicide by bromazepame poisoning. This was subsequently followed by major ischemic stroke caused by thrombosis of the left middle cerebral artery (probably due to aortic arch embolism) successfully treated with intravenous thrombolysis. Conclusion: Intravenous thrombolysis appears to be safe and effective in patients with TA and stroke.
[Mh] Termos MeSH primário: Ansiolíticos/envenenamento
Isquemia Encefálica/induzido quimicamente
Isquemia Encefálica/terapia
Bromazepam/envenenamento
Tentativa de Suicídio
Arterite de Takayasu/psicologia
Terapia Trombolítica
[Mh] Termos MeSH secundário: Depressão/etiologia
Feminino
Fibrinolíticos/uso terapêutico
Seres Humanos
Meia-Idade
Recidiva
Terapia Trombolítica/métodos
Ativador de Plasminogênio Tecidual/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Fibrinolytic Agents); EC 3.4.21.68 (Tissue Plasminogen Activator); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150717092K


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[PMID]:27331303
[Au] Autor:Purg D; Markota A; Grenc D; Sinkovic A
[Ti] Título:Low-dose intravenous lipid emulsion for the treatment of severe quetiapine and citalopram poisoning.
[So] Source:Arh Hig Rada Toksikol;67(2):164-6, 2016 Jun 01.
[Is] ISSN:1848-6312
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:The treatment of quetiapine and/or citalopram poisoning is mainly supportive and involves gastric lavage, activated charcoal, intubation, and mechanical ventilation. Recently, however, there were reports of successful treatment with intravenous lipid emulsion. Here we report a case of a 19-year-old Caucasian girl who ingested approximately 6000 mg of quetiapine, 400 mg of citalopram, and 45 mg of bromazepam in a suicide attempt. The patient developed ventricular tachycardia and epileptic seizures 12 h after admission to the hospital. As the patient's condition deteriorated, we combined standard therapy (intubation, mechanical ventilation, and vasopressors) with low-dose intravenous lipid emulsion (ILE) (a total of 300 mL of 20 % lipid emulsion) and normalised her heart rhythm and stopped the seizures. She was discharged to the psychiatric ward after 48 h and home after a prolonged (2-month) psychiatric rehabilitation. Intravenous lipid emulsion turned out to be effective even in the lower dose range than previously reported for quetiapine poisoning in patients presenting with seizure and ventricular arrhythmia. To our knowledge, there are no case reports describing the use of ILE in treating citalopram poisoning.
[Mh] Termos MeSH primário: Antidepressivos de Segunda Geração/envenenamento
Antipsicóticos/envenenamento
Bromazepam/envenenamento
Citalopram/envenenamento
Overdose de Drogas/tratamento farmacológico
Emulsões Gordurosas Intravenosas/uso terapêutico
Fumarato de Quetiapina/envenenamento
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Eslovênia
Tentativa de Suicídio
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents, Second-Generation); 0 (Antipsychotic Agents); 0 (Fat Emulsions, Intravenous); 0DHU5B8D6V (Citalopram); 2S3PL1B6UJ (Quetiapine Fumarate); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE


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[PMID]:27295906
[Au] Autor:Vukcevic NP; Ercegovic GV; Segrt Z; Djordjevic S; Stosic JJ
[Ti] Título:Benzodiazepine poisoning in elderly.
[So] Source:Vojnosanit Pregl;73(3):234-8, 2016 Mar.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Benzodiazepines are among the most frequently ingested drugs in self-poisonings. Elderly may be at greater risk compared with younger individuals due to impaired metabolism and increased sensitivity to benzodiazepines. The aim of this study was to assess toxicity of benzodiazepines in elderly attempted suicide. METHODS: A retrospective study of consecutive presentations to hospital after self-poisoning with benzodiazepines was done. Collected data consisted of patient's characteristics (age, gender), benzodiazepine ingested with its blood concentrations at admission, clinical findings including vital signs and Glasgow coma score, routine blood chemistry, complications of poisoning, details of management, length of hospital stay and outcome. According the age, patients are classified as young (15-40-year old), middle aged (41-65-year old) and elderly (older than 65). RESULTS: During a 2-year observational period 387 patients were admitted because of pure benzodiazepine poisoning. The most frequently ingested drug was bromazepam, the second was diazepam. The incidence of coma was significantly higher, and the length of hospital stay significantly longer in elderly. Respiratory failure and aspiration pneumonia occurred more frequently in old age. Also, flumazenil was more frequently required in the group of elderly patients. CONCLUSION: Massive benzodiazepines overdose in elderly may be associated with a significant morbidity, including deep coma with aspiration pneumonia, respiratory failure, and even death. Flumazenil is indicated more often to reduce CNS depression and prevent complications of prolonged unconsciousness, but supportive treatment and proper airway management of comatose patients is the mainstay of the treatment of acute benzodiazepine poisoning.
[Mh] Termos MeSH primário: Benzodiazepinas/envenenamento
Coma/epidemiologia
Overdose de Drogas/epidemiologia
Pneumonia Aspirativa/epidemiologia
Insuficiência Respiratória/epidemiologia
Tentativa de Suicídio/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Antídotos/uso terapêutico
Bromazepam/envenenamento
Estudos de Coortes
Coma/induzido quimicamente
Diazepam/envenenamento
Overdose de Drogas/tratamento farmacológico
Feminino
Flumazenil/uso terapêutico
Seres Humanos
Incidência
Tempo de Internação
Lorazepam/envenenamento
Masculino
Meia-Idade
Pneumonia Aspirativa/induzido quimicamente
Insuficiência Respiratória/induzido quimicamente
Estudos Retrospectivos
Sérvia/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Antidotes); 12794-10-4 (Benzodiazepines); 40P7XK9392 (Flumazenil); O26FZP769L (Lorazepam); Q3JTX2Q7TU (Diazepam); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160614
[Lr] Data última revisão:
160614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE


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[PMID]:27293065
[Au] Autor:Rivollier F; Masson M
[Ad] Endereço:Inserm UMR 894, laboratoire « physiopathologie des maladies psychiatriques ¼, université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France; Service hospitalo-universitaire, hôpital Sainte-Anne, université Paris Descartes, Paris, France. Electronic address: f.rivollier@gmail.com.
[Ti] Título:[Manic symptoms induced by high doses of baclofen: A case report].
[Ti] Título:Symptômes maniaques induits par de fortes doses de baclofène : à propos d'un cas..
[So] Source:Encephale;42(4):382-3, 2016 Aug.
[Is] ISSN:0013-7006
[Cp] País de publicação:France
[La] Idioma:fre
[Mh] Termos MeSH primário: Baclofeno/efeitos adversos
Transtorno Bipolar/induzido quimicamente
Transtorno Bipolar/psicologia
Agonistas GABAérgicos/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Alcoolismo/tratamento farmacológico
Antimaníacos/uso terapêutico
Baclofeno/uso terapêutico
Transtorno Bipolar/tratamento farmacológico
Bromazepam/uso terapêutico
Agonistas GABAérgicos/uso terapêutico
Seres Humanos
Masculino
Escalas de Graduação Psiquiátrica
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Antimanic Agents); 0 (GABA Agonists); H789N3FKE8 (Baclofen); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160614
[St] Status:MEDLINE


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Ribeiro, Pedro
Texto completo SciELO Brasil
[PMID]:26517214
[Au] Autor:Aprigio D; Adolfo W; Bittencourt J; Gongora M; Teixeira S; Basile LF; Budde H; Cagy M; Ribeiro P; Velasques B
[Ad] Endereço:Instituto de Psiquiatria, Neurofisiologia e Neuropsicologia da Atenção, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
[Ti] Título:Alpha power oscillation in the frontal cortex under Bromazepam and Modafinil effects.
[So] Source:Arq Neuropsiquiatr;73(11):918-23, 2015 Nov.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Our aim was to investigate and compare the neuromodulatory effects of bromazepam (6 mg) and modafinil (200 mg) during a sensorimotor task analyzing the changes produced in the absolute alpha power. METHOD: The sample was composed of 15 healthy individuals exposed to three experimental conditions: placebo, modafinil and bromazepam. EEG data were recorded before, during and after the execution of the task. A three-way ANOVA was applied, in order to compare the absolute alpha power among the factors: Group (control, bromazepam and modafinil) Condition (Pre and Post-drug ingestion) and Moment (pre and post-stimulus). RESULTS: Interaction was found between the group and condition factors for Fp1, F4 and F3. We observed a main effect of moment and condition for the Fp2, F8 and Fz electrodes. CONCLUSION: We concluded that drugs may interfere in sensorimotor processes, such as in the performance of tasks carried out in an unpredictable scenario.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/farmacologia
Bromazepam/farmacologia
Lobo Frontal/efeitos dos fármacos
Moduladores GABAérgicos/farmacologia
Desempenho Psicomotor/efeitos dos fármacos
Córtex Somatossensorial/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Ondas Encefálicas/efeitos dos fármacos
Eletroencefalografia/efeitos dos fármacos
Métodos Epidemiológicos
Feminino
Lobo Frontal/fisiologia
Seres Humanos
Masculino
Valores de Referência
Córtex Somatossensorial/fisiologia
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (GABA Modulators); R3UK8X3U3D (modafinil); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151031
[Lr] Data última revisão:
151031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151031
[St] Status:MEDLINE


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[PMID]:26259848
[Au] Autor:Otera M; Machida T; Machida T; Abe M; Ichie M; Fukudo S
[Ad] Endereço:Translational Medical Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi cho, Kodaira shi, Tokyo, 187-8551, Japan. otera@med.tohoku.ac.jp.
[Ti] Título:Pharmacological and psychosomatic treatments for an elderly patient with severe nausea and vomiting in reaction to postoperative stress.
[So] Source:Clin J Gastroenterol;8(5):275-9, 2015 Oct.
[Is] ISSN:1865-7265
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Here we present a case of successful treatment employing a mixed approach including pharmacological and psychosomatic treatments for a 72-year-old woman who experienced severe nausea and vomiting in reaction to postoperative stress from gastric cancer surgery. This case demonstrates that appropriate provision of psychosomatic treatments, including a psychotherapeutic session and autogenic training, enhances the efficacy of pharmacotherapy.
[Mh] Termos MeSH primário: Ansiolíticos/uso terapêutico
Antidepressivos/uso terapêutico
Antieméticos/uso terapêutico
Náusea/terapia
Complicações Pós-Operatórias/psicologia
Psicoterapia
Estresse Psicológico/complicações
Vômito/terapia
[Mh] Termos MeSH secundário: Idoso
Amoxapina/uso terapêutico
Benzodiazepinas/uso terapêutico
Bromazepam/uso terapêutico
Clomipramina/uso terapêutico
Terapia Combinada
Feminino
Seres Humanos
Mianserina/análogos & derivados
Mianserina/uso terapêutico
Náusea/etiologia
Modalidades de Fisioterapia
Neoplasias Gástricas/cirurgia
Vômito/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Antidepressive Agents); 0 (Antiemetics); 12794-10-4 (Benzodiazepines); 250PJI13LM (Mianserin); A051Q2099Q (mirtazapine); N7U69T4SZR (olanzapine); NUV44L116D (Clomipramine); R63VQ857OT (Amoxapine); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150812
[St] Status:MEDLINE
[do] DOI:10.1007/s12328-015-0592-9


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[PMID]:26061352
[Au] Autor:Schaefer IC; Siebel AM; Piato AL; Bonan CD; Vianna MR; Lara DR
[Ad] Endereço:aNeurochemistry and Psychopharmacology Laboratory bDevelopment Biology Laboratory, Cellular and Molecular Biology Department, Faculty of Bioscience, Pontifical Catholic University of Rio Grande do Sul cNational Institute of Science and Technology in Translational Medicine dPharmacology Department, Basic Health Sciences Insitute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
[Ti] Título:The side-by-side exploratory test: a simple automated protocol for the evaluation of adult zebrafish behavior simultaneously with social interaction.
[So] Source:Behav Pharmacol;26(7 Spec No):691-6, 2015 Oct.
[Is] ISSN:1473-5849
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The assessment of shoaling in adult zebrafish is technically difficult, but important, given their social nature. The present study aimed to characterize a new protocol using simple automated tracking software to evaluate general behavior and social interaction simultaneously. To this end, we used a single tank with a central transparent glass division and placed one zebrafish on each side for 5 min. This strategy allows fish to interact visually at the same time that individual automated evaluation of behavior can be easily performed. Our results showed that, when two fish are placed side-by-side, there is an increase in their height in the tank compared with isolated fish and they remain close to each other. The pharmacological treatments with benzodiazepines (bromazepam and clonazepam) and the serotonergic drugs buspirone, fluoxetine, and escitalopram did not affect locomotion at the concentrations tested, except for the highest concentration of buspirone. Nevertheless, benzodiazepines increased interfish distance (i.e. reduced shoaling behavior) and serotonergic drugs elevated height in the tank. These results support the use of the side-by-side exploratory test for behavioral studies with the zebrafish, including high-throughput behavioral screening for antidepressants and anxiolytics.
[Mh] Termos MeSH primário: Comportamento Exploratório
Reconhecimento Automatizado de Padrão/métodos
Testes Psicológicos
Comportamento Social
Software
Peixe-Zebra
[Mh] Termos MeSH secundário: Animais
Bromazepam/farmacologia
Buspirona/farmacologia
Citalopram/farmacologia
Clonazepam/farmacologia
Relação Dose-Resposta a Droga
Comportamento Exploratório/efeitos dos fármacos
Medo
Feminino
Fluoxetina/farmacologia
Masculino
Psicotrópicos/farmacologia
Estresse Psicológico
Visão Ocular
Peixe-Zebra/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Psychotropic Drugs); 01K63SUP8D (Fluoxetine); 0DHU5B8D6V (Citalopram); 5PE9FDE8GB (Clonazepam); TK65WKS8HL (Buspirone); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150901
[Lr] Data última revisão:
150901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150611
[St] Status:MEDLINE
[do] DOI:10.1097/FBP.0000000000000145


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Ribeiro, Pedro
Texto completo SciELO Brasil
[PMID]:25992523
[Au] Autor:Fortunato S; Tanaka GK; Araújo F; Bittencourt J; Aprigio D; Gongora M; Teixeira S; Pompeu FA; Cagy M; Basile LF; Ribeiro P; Velasques B
[Ad] Endereço:Departamento de Neurofisiologia e Neuropsicologia, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
[Ti] Título:The effects of bromazepam over the central and frontal areas during a motor task: an EEG study.
[So] Source:Arq Neuropsiquiatr;73(4):321-9, 2015 Apr.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The present study investigates the influence of bromazepam while executing a motor task. Specifically, we intend to analyze the changes in alpha absolute power under two experimental conditions, bromazepam and placebo. We also included analyses of theta and beta frequencies. We collected electroencephalographic data before, during, and after motor task execution. We used a Two Way ANOVA to investigate the condition (PL × Br6 mg) and moment (pre and post) variables for the following electrodes: Fp1, Fp2, F7, F3, Fz, F4, F8, C3, CZ and C4. We found a main effect for condition on the electrodes FP1, F7, F3, Fz, F4, C3 and CZ, for alpha and beta bands. For beta band we also found a main effect for condition on the electrodes Fp2, F8 and C4; for theta band we identified a main effect for condition on C3, Cz and C4 electrodes. This finding suggests that the motor task did not have any influence on the electrocortical activity in alpha, and that the existing modifications were a consequence due merely to the drug use. Despite its anxiolytic and sedative action, bromazepam did not show any significant changes when the individuals executed a finger extension motor task.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Bromazepam/farmacologia
Lobo Frontal/efeitos dos fármacos
Destreza Motora/efeitos dos fármacos
Córtex Somatossensorial/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Ondas Encefálicas/efeitos dos fármacos
Método Duplo-Cego
Eletroencefalografia/efeitos dos fármacos
Feminino
Lobo Frontal/fisiologia
Seres Humanos
Masculino
Atividade Motora/efeitos dos fármacos
Valores de Referência
Córtex Somatossensorial/fisiologia
Análise e Desempenho de Tarefas
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150521
[Lr] Data última revisão:
150521
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150521
[St] Status:MEDLINE


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[PMID]:25700112
[Au] Autor:Uekusa K; Hayashida M; Ohno Y
[Ad] Endereço:Department of Legal Medicine, Nippon Medical School, Tokyo, Japan. Electronic address: uekusa@nms.ac.jp.
[Ti] Título:Forensic toxicological analyses of drugs in tissues in formalin solutions and in fixatives.
[So] Source:Forensic Sci Int;249:165-72, 2015 Apr.
[Is] ISSN:1872-6283
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Forensic toxicological drug analyses of human specimens are usually performed immediately after autopsy or on frozen preserved tissues. Occasionally, cases require analysis of drugs from tissues fixed in formalin solution. To improve the estimation of the level of drug in tissues following formalin fixation, we studied drug concentrations in human tissues, liver and kidney, that were collected from a drug-positive autopsy case. Parts of tissues were preserved in formalin solution for 1, 3, 6 and 13 months. Tissues obtained before and after preservation, along with tissue-exposed fixatives, were assayed using gas chromatography-mass spectrometry; all of the samples were assayed for the presence of drugs and changes in the drug concentrations both before and after preservation in formalin. Concentrations of assayed drugs decreased upon fixation in formalin; levels of these drugs did not necessarily show further decreases during subsequent storage in fixative, up to 13 months. Distinct trends in drug levels were found in liver and kidney. In liver, the levels of chlorpromazine, levomepromazine, and promethazine decreased to 23-39% at 1 month after preservation; all 3 of these drugs were detected at all tested time points of preservation. Bromazepam was not detected at 13 months after preservation. Milnacipran was the most unstable after preservation in formalin solution among all of the assayed drugs. In kidney, all assayed drugs exhibited reduced stability during preservation compared to levels in liver. Methamphetamine and methylenedioxymethamphetamine were not detected in any time points of tissues. The proportions of the drugs that remained within the tissues differed between liver and kidney. Also, S-oxide compounds of chlorpromazine and levomepromazine, which were not observed before preservation, were detected in fixed liver tissues and their fixatives at 3, 6 and 13 months of preservation. These results suggest that analyses in formalin-fixed tissues need to include analysis of various organ-tissues and their fixatives at multiple time points for the duration of preservation. These analyses should include detection of chemical degradation/denaturation products, such as S-oxides of chlorpromazine and levomepromazine.
[Mh] Termos MeSH primário: Antipsicóticos/análise
Fixadores
Formaldeído
Rim/química
Fígado/química
Entorpecentes/análise
Preservação de Órgãos/métodos
[Mh] Termos MeSH secundário: Adulto
Bromazepam/análise
Clorpromazina/análise
Ciclopropanos/análise
Estabilidade de Medicamentos
Toxicologia Forense
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Masculino
Metanfetamina/análise
Metotrimeprazina/análise
N-Metil-3,4-Metilenodioxianfetamina/análise
Prometazina/análise
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Cyclopropanes); 0 (Fixatives); 0 (Narcotics); 1HG84L3525 (Formaldehyde); 44RAL3456C (Methamphetamine); 9G0LAW7ATQ (Methotrimeprazine); FF28EJQ494 (Promethazine); G56VK1HF36 (milnacipran); KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine); U42B7VYA4P (Chlorpromazine); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150330
[Lr] Data última revisão:
150330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150221
[St] Status:MEDLINE


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[PMID]:25450508
[Au] Autor:Kintz P
[Ad] Endereço:X-Pertise Consulting, 84 route de Saverne, F-67205 Oberhausbergen, France; Institut de Médecine légale, 11 rue Humann, F-67000 Strasbourg, France. Electronic address: pascal.kintz@wanadoo.fr.
[Ti] Título:Contribution of in utero drug exposure when interpreting hair results in young children.
[So] Source:Forensic Sci Int;249:314-7, 2015 Apr.
[Is] ISSN:1872-6283
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Hair specimen is necessary to complement blood and/or urine analyses as it permits differentiation of a single exposure from chronic use of a drug by segmentation of the hair for a stated growth period. Moreover, due to a frequent long delay between event and police declaration, hair can be the only solution for lack of corroborative evidence of a committed crime. With the exception of lower amount of biological material in children versus adults, there is no specific analytical problem when processing samples from children. The issue is the interpretation of the findings, with respect to the different pharmacological parameters. In some very young children, the interpretation can be complicated by potential in utero exposure. Twenty-four cases from daily practice have been reviewed. Children were less than 1 year old, hair was always longer than 4 cm and the corresponding mothers admitted having used drugs during pregnancy. Drugs involved include methadone, tramadol, diphenhydramine, diazepam, cannabis, heroin, amitriptyline and bromazepam. Analyses were achieved by hyphenated chromatographic validated procedures after hair decontamination and segmentation. The concentrations measured in the hair of children were lower than those observed in subjects using therapeutically (or illegally) these drugs. In that sense, the frequency of exposures appears as un-frequent (low level of exposure), with marked decrease in the more recent period. However, the parents denied any administration in all cases and there was no reason to suspect re-exposure after delivery and no clinical problem during the period between delivery and hair collection during regular visits to the physician was noticed. The pattern of drug distribution was similar in all these cases, low concentrations in the proximal segments and highest concentration in the distal segment (last segment). When considering the concentration in the distal segment as the 100% of the response (highest concentration), after analysis of 4 segments (irrespective of the length of the segment but longer than 1cm), it was observed the following pattern: proximal segment, 5-35% of the response; segment 2, 15-50% of the response; segment 3, 25-60% of the response; and distal segment, 100% of the response. It is proposed to consider 100% in utero contribution to the final interpretation when the ratio concentration of the proximal segment to the concentration of the distal segment is lower than 0.5. This can be applied only when the child is under 1 year old and the hair shaft length is at least 4 cm (to achieve suitable segmentation). It is important, when using this cut-off to have at least 3 or 4 segments to be able to observe the variation in drug concentrations, whatever the length of each segment (>1cm).
[Mh] Termos MeSH primário: Cabelo/química
Hipnóticos e Sedativos/análise
Troca Materno-Fetal
Entorpecentes/análise
Transtornos Relacionados ao Uso de Substâncias/complicações
[Mh] Termos MeSH secundário: Amitriptilina/análise
Bromazepam/análise
Canabinoides/análise
Diazepam/análise
Difenidramina/análise
Feminino
Toxicologia Forense
Heroína/análise
Seres Humanos
Lactente
Recém-Nascido
Masculino
Metadona/análise
Gravidez
Tramadol/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cannabinoids); 0 (Hypnotics and Sedatives); 0 (Narcotics); 1806D8D52K (Amitriptyline); 39J1LGJ30J (Tramadol); 70D95007SX (Heroin); 8GTS82S83M (Diphenhydramine); Q3JTX2Q7TU (Diazepam); UC6VBE7V1Z (Methadone); X015L14V0O (Bromazepam)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150330
[Lr] Data última revisão:
150330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE



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