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[PMID]:25857879
[Au] Autor:Yilmaz B; Erdem AF
[Ad] Endereço:Ataturk University, Faculty of Pharmacy, Department of Analytical Chemistry, 25240, Erzurum, Turkey.
[Ti] Título:Simultaneous Determination of Tramadol and its Metabolite in Human Plasma by GC/MS.
[So] Source:J AOAC Int;98(1):56-61, 2015 Jan-Feb.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A simple and sensitive GC/MS method for the determination of tramadol and its metabolite (O-desmethyltramadol) in human plasma was developed and validated. Medazepam was used as an internal standard. The calibration curves were linear (r=0.999) over tramadol and O-desmethyltramadol concentrations ranging from 10 to 200 ng/mL and 7.5 to 300 ng/mL, respectively. The method had an accuracy of >95% and intra- and interday precision (RSD%) of ≤4.83% and ≤4.68% for tramadol and O-desmethyltramadol, respectively. The extraction recoveries were 97.6±1.21% and 96.3±1.66% for tramadol and O-desmethyltramadol, respectively. The LOQ using 0.5 mL human plasma was 10 ng/mL for tramadol and 7.5 ng/mL for O-desmethyltramadol. Stability studies showed that tramadol and O-desmethyltramadol were stable in human plasma after 8 h incubation at room temperature or after 1 week storage at -20°C with three freeze-thaw cycles. Also, this method was successfully applied to six patients who had been given an intravenous formulation of 100 mg tramadol with Cmax results of 2018.1±687.8 and 96.1±22.7 ng/mL for tramadol and O-desmethyltramadol, respectively.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas/métodos
Tramadol/análogos & derivados
Tramadol/sangue
Tramadol/farmacocinética
[Mh] Termos MeSH secundário: Analgésicos Opioides/sangue
Analgésicos Opioides/química
Analgésicos Opioides/farmacocinética
Área Sob a Curva
Seres Humanos
Medazepam/sangue
Medazepam/química
Estrutura Molecular
Reprodutibilidade dos Testes
Tramadol/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 2WA8F50C3F (O-demethyltramadol); 39J1LGJ30J (Tramadol); P0J3387W3S (Medazepam)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150411
[St] Status:MEDLINE
[do] DOI:10.5740/jaoacint.14-085


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[PMID]:25674736
[Au] Autor:Iqbal U; Nguyen PA; Syed-Abdul S; Yang HC; Huang CW; Jian WS; Hsu MH; Yen Y; Li YC
[Ad] Endereço:From the Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan (UI, P-AN, SS-A, H-CY, CWH, M-HH, YY, YC(J)L); Institute of Biomedical Informatics, National Yang Ming University, Taipei, Taiwan (H-CY); School of Health Care Administration, Taipei Medical University, Taipei, Taiwan (W-SJ); Department of Health, Taipei Hospital, Taiwan (M-HH); City of Hope, Duarte, CA, USA (YY); Department of Dermatology, Wan Fang Hospital, Taipei, Taiwan (Y-C(J)L).
[Ti] Título:Is long-term use of benzodiazepine a risk for cancer?
[So] Source:Medicine (Baltimore);94(6):e483, 2015 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The carcinogenicity of benzodiazepines (BZDs) is still unclear. We aimed to assess whether long-term benzodiazepines use is risk for cancer.We conducted a longitudinal population-based case-control study by using 12 years from Taiwan National Health Insurance database and investigated the association between BZDs use and cancer risk of people aged over 20 years. During the study period, 42,500 cases diagnosed with cancer were identified and analyzed for BZDs use. For each case, six eligible controls matched for age, sex, and the index date (ie, free of any cancer in the date of case diagnosis) by using propensity score. For appropriate risk estimation, we observed the outcomes according to their length of exposure (LOE) and defined daily dose (DDD). To mimic bias, we adjusted with potential confounding factors such as medications and comorbid diseases which could influence for cancer risk during the study period. The data was analyzed by using Cox proportional hazard regression and conditional logistic regression.The finding unveils benzodiazepines use into safe and unsafe groups for their carcinogenicity. The use of diazepam (HR, 0.96; 95%CI, 0.92-1.00), chlorodizepoxide (HR, 0.98; 95%CI, 0.92-1.04), medazepam (HR, 1.01; 95%CI, 0.84-1.21), nitrazepam (HR, 1.06; 95%CI, 0.98-1.14), oxazepam (HR, 1.05; 95%CI, 0.94-1.17) found safer among BZDs. However, clonazepam (HR, 1.15; 95%CI, 1.09-1.22) were associated with a higher risk for cancers. Moreover, specific cancer risk among BZDs use was observed significantly increased 98% for brain, 25% for colorectal, and 10% for lung, as compared with non-BZDs use.Diazepam, chlordiazepoxide, medazepam, nitrazepam, and oxazepam are safe among BZDs use for cancer risk. Our findings could help physicians to select safer BZDs and provide an evidence on the carcinogenic effect of benzodiazepines use by considering the LOE and DDD for further research.
[Mh] Termos MeSH primário: Benzodiazepinas/efeitos adversos
Carcinógenos
[Mh] Termos MeSH secundário: Benzodiazepinas/administração & dosagem
Estudos de Casos e Controles
Clordiazepóxido/efeitos adversos
Clonazepam/efeitos adversos
Diazepam/efeitos adversos
Feminino
Seres Humanos
Modelos Logísticos
Estudos Longitudinais
Masculino
Medazepam/efeitos adversos
Meia-Idade
Nitrazepam/efeitos adversos
Oxazepam/efeitos adversos
Modelos de Riscos Proporcionais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carcinogens); 12794-10-4 (Benzodiazepines); 5PE9FDE8GB (Clonazepam); 6GOW6DWN2A (Oxazepam); 6RZ6XEZ3CR (Chlordiazepoxide); 9CLV70W7HS (Nitrazepam); P0J3387W3S (Medazepam); Q3JTX2Q7TU (Diazepam)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150213
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000000483


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[PMID]:24664310
[Au] Autor:Sayiner ZA; Ozturk ZA
[Ad] Endereço:Department of Internal Medicine, Gaziantep University Faculty of Medicine, 27100, Sahinbey, Gaziantep, Turkey, zeynelasayiner@hotmail.com.
[Ti] Título:Acute kidney injury with medazepam-hyoscine buthylbromide.
[So] Source:Wien Klin Wochenschr;126(9-10):291-3, 2014 May.
[Is] ISSN:1613-7671
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:An 84-year-old female patient was admitted to our internal medicine outpatient clinic complaining of stomach ache, nausea, and vomiting. She had hepatitis C infection for 10 years that was managed with antiviral treatment. On the second day of admission, she developed anxiety and complained about dysuria. Medazepam and hyoscine butylbromide combined tablet was administered. The day after medazepam and hyoscine butylbromide administration, patient's creatinine level increased to 2.3 mg/dL (0.57-1.11 mg/dL). Medazepam and hyoscine butylbromide administration was stopped on the fourth day. After 10 days of follow-up, her creatinine levels were normalized. In this article, we present an elderly patient with acute kidney injury induced by medazepam and hyoscine butylbromide that was managed with best supportive care.
[Mh] Termos MeSH primário: Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/prevenção & controle
Brometo de Butilescopolamônio/efeitos adversos
Medazepam/efeitos adversos
Parassimpatolíticos/efeitos adversos
[Mh] Termos MeSH secundário: Lesão Renal Aguda/diagnóstico
Idoso de 80 Anos ou mais
Ansiolíticos/efeitos adversos
Quimioterapia Combinada/efeitos adversos
Feminino
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Parasympatholytics); 2Z3E1OF81V (Butylscopolammonium Bromide); P0J3387W3S (Medazepam)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140326
[St] Status:MEDLINE
[do] DOI:10.1007/s00508-014-0523-7


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[PMID]:20446010
[Au] Autor:Millefiori S; Alparone A
[Ad] Endereço:Dipartimento di Scienze Chimiche, Università di Catania, Catania, Italy. smillefiori@unict.it
[Ti] Título:Electronic properties of neuroleptics: ionization energies of benzodiazepines.
[So] Source:J Mol Model;17(2):281-7, 2011 Feb.
[Is] ISSN:0948-5023
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Vertical ionization energies (VIEs) of medazepam, nordazepam and their molecular subunits have been calculated using the electron propagator method in the P3/CEP-31G* approximation. Vertical electron affinities (VEAs) have been obtained with a ∆SCF procedure at the DFT-B3LYP/6-31+G* level of theory. Excellent correlations have been achieved between IE(calc) and IE(exp), allowing reliable assignment of the ionization processes. Our proposed assignment differs in many instances from that previously reported in the literature. The electronic structure of the frontier Dyson orbitals shows that the IE and EA values of the benzodiazepines can be modulated by substitution at the benzene rings. Hardness values, evaluated as (IE - EA)/2, follow the trend of the experimental singlet transition energies. Medazepam is a less hard (i.e., less stable) compound than nordazepam.
[Mh] Termos MeSH primário: Antipsicóticos/química
Medazepam/química
Nordazepam/química
[Mh] Termos MeSH secundário: Elétrons
Modelos Químicos
Modelos Moleculares
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); 67220MCM01 (Nordazepam); P0J3387W3S (Medazepam)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100507
[St] Status:MEDLINE
[do] DOI:10.1007/s00894-010-0723-7


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[PMID]:20080160
[Au] Autor:Vrzal R; Kubesova K; Pavek P; Dvorak Z
[Ad] Endereço:Department of Cell Biology and Genetics, Faculty of Science, Palacky University Olomouc, Slechtitelu 11, 783 71 Olomouc, Czech Republic.
[Ti] Título:Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.
[So] Source:Toxicol Lett;193(2):183-8, 2010 Mar 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Benzodiazepines have wide-spread used in pharmacotherapy for their anxiolytic, myorelaxant, hypnotic, amnesic and anticonvulsive properties. Despite benzodiazepines are used in clinics over 50 years, they have not been surprisingly tested for capability to induce major drug-metabolizing cytochromes P450. In the current study, we have examined the potency of Alprazolam, Bromazepam, Chlordiazepoxide, Clonazepam, Diazepam, Lorazepam, Medazepam, Midazolam, Nitrazepam, Oxazepam, Tetrazepam and Triazolam to induce CYP1A2 and CYP3A4 in primary cultures of human hepatocytes. Benzodiazepines were tested in therapeutic concentrations and in concentrations corresponding to their plasma levels in intoxicated patients. We found weak but significant induction of CYP3A4 mRNA by Midazolam and Medazepam, while other benzodiazepines did not induce CYP3A4 expression. None of the tested compounds induced CYP1A2 mRNA in three independent human hepatocytes cultures. In addition, employing gene reporter assays with transiently transfected hepatocarcinoma cells, we found that tested benzodiazepines did not activate aryl hydrocarbon receptor (AhR), whereas Midazolam and Medazepam slightly activated pregnane X receptor (PXR). Consistently, two-hybrid mammalian assay using hybrid fusion plasmids GAL4-PXR ligand-binding domain (LBD) and VP16-SRC-1-receptor-interacting domain (RID) confirmed PXR activation by Midazolam and Medazepam. In conclusion, Alprazolam, Bromazepam, Chlordiazepoxide, Clonazepam, Diazepam, Lorazepam, Nitrazepam, Oxazepam, Tetrazepam and Triazolam can be considered as safe drugs in term of their inability to induce PXR- and AhR-dependent cytochrome P450 enzymes CYP1A2 and CYP3A4. Medazepam and Midazolam slightly activated pregnane X receptor and displayed weak potency to induce CYP3A4 mRNA in human hepatocytes.
[Mh] Termos MeSH primário: Ansiolíticos/toxicidade
Citocromo P-450 CYP3A/metabolismo
Medazepam/toxicidade
Midazolam/toxicidade
Receptores de Esteroides/metabolismo
[Mh] Termos MeSH secundário: Carcinoma Hepatocelular
Células Cultivadas
Citocromo P-450 CYP1A1/genética
Citocromo P-450 CYP1A1/metabolismo
Citocromo P-450 CYP1A2/genética
Citocromo P-450 CYP1A2/metabolismo
Citocromo P-450 CYP3A/genética
Indução Enzimática/efeitos dos fármacos
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Células Hep G2
Hepatócitos/efeitos dos fármacos
Hepatócitos/enzimologia
Seres Humanos
Neoplasias Hepáticas
Coativador 1 de Receptor Nuclear/metabolismo
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (RNA, Messenger); 0 (Receptors, Steroid); 0 (pregnane X receptor); EC 1.14.14.1 (Cytochrome P-450 CYP1A1); EC 1.14.14.1 (Cytochrome P-450 CYP1A2); EC 1.14.14.1 (Cytochrome P-450 CYP3A); EC 2.3.1.48 (Nuclear Receptor Coactivator 1); P0J3387W3S (Medazepam); R60L0SM5BC (Midazolam)
[Em] Mês de entrada:1004
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100119
[St] Status:MEDLINE
[do] DOI:10.1016/j.toxlet.2010.01.004


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[PMID]:18818182
[Au] Autor:Gidai J; Acs N; Bánhidy F; Czeizel AE
[Ad] Endereço:Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary.
[Ti] Título:A study of the effects of large doses of medazepam used for self-poisoning in 10 pregnant women on fetal development.
[So] Source:Toxicol Ind Health;24(1-2):61-8, 2008 Feb-Mar.
[Is] ISSN:0748-2337
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this article is to report an evaluation of the teratogenic and fetotoxic potential of medezepam in humans based on pregnant women who used very large doses of medazepam for a suicide attempt. All self-poisoned patients were cared for at the Department of Toxicology Internal Medicine, Koranyi Hospital, a toxicological inpatients clinic in Budapest, Hungary, between 1960 and 1993. Pregnant women were identified from self-poisoned subjects admitted from a population base of three million people of Budapest and the surrounding region. The rates of congenital abnormalities (CAs), intrauterine fetal development, cognitive and behavioral status in children born to mothers who attempted suicide with medazepam alone or in combination with other drugs during pregnancy was compared in their sib controls. Between 1980 and 1993, 835 pregnant women in our study attempted suicide during pregnancy with drugs. Of these, 314 delivered live-born infants and 283 were examined and/or evaluated. Thirty-two (3.8%) of these 835 pregnant women used medazepam with or without other drugs for self-poisoning; 10 of these women delivered live-born babies. The dose of medazepam used for the suicide attempt ranged between 60 and 500 mg, with a mean of 276 mg. Eight of the 32 suicide attempts involving medazepam occurred between the 4th and 12th postconceptional weeks. Of the 10 live-born exposed children, one was affected with congenital inguinal hernia; one of the 13 sib controls had a lethal hydronephrosis. No adverse effects were observed on intrauterine growth, cognitive status, or behavioral deviations in the 10 children born to mothers who attempted suicide with medazepam during pregnancy. Very large doses of medazepam were used for self-poisoning during pregnancy. These doses did not increase the rate of CAs even though eight mothers attempted suicide during the most critical period for production of CAs. No fetotoxic, including neurotoxic, effects of exposure of live-born children to a very large dose of medazepam were observed. Our experiences show the feasibility and benefits of use of the self-poisoning model in estimating human teratogenic and fetotoxic risks of drugs.
[Mh] Termos MeSH primário: Anormalidades Induzidas por Medicamentos/etiologia
Desenvolvimento Fetal/efeitos dos fármacos
Medazepam/envenenamento
Gestantes
Tentativa de Suicídio/estatística & dados numéricos
[Mh] Termos MeSH secundário: Anormalidades Induzidas por Medicamentos/epidemiologia
Adolescente
Adulto
Ansiolíticos/envenenamento
Estudos de Casos e Controles
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Hungria/epidemiologia
Lactente
Recém-Nascido
Masculino
Gravidez
Efeitos Tardios da Exposição Pré-Natal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); P0J3387W3S (Medazepam)
[Em] Mês de entrada:0901
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080927
[St] Status:MEDLINE
[do] DOI:10.1177/0748233708089016


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[PMID]:18454096
[Au] Autor:Zozulia AA; Neznamov GG; Siuniakov TS; Kost NV; Gabaeva MV; Sokolov OIu; Serebriakova EV; Siranchieva OA; Andriushenko AV; Telesheva ES; Siuniakov SA; Smulevich AB; Miasoedov NF; Seredenin SB
[Ti] Título:[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;108(4):38-48, 2008.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied. The effect of selank (30 patients) was compared to that of medazepam (32 patients). Patient's state was assessed with psychometric scales (Hamilton, Zung, CGI). Enkephalin activity in the blood serum was measured as well. The anxiolytic effects of both drugs were similar but selank had also antiasthenic and psychostimulant effects. The clinical-biological study revealed that patients with GAD and neurasthenia had the decreased level of tau(1/2) leu-enkephalin which was correlated with disease duration, severity of symptoms related to anxiety and asthenia and autonomic disorders. The increase of this parameter and stronger positive correlations with anxiety level were observed during the treatment with selank mostly in patients with GAD.
[Mh] Termos MeSH primário: Transtornos de Ansiedade/tratamento farmacológico
Neurastenia/tratamento farmacológico
Oligopeptídeos/administração & dosagem
[Mh] Termos MeSH secundário: Administração Intranasal
Administração Oral
Adolescente
Adulto
Ansiolíticos/administração & dosagem
Ansiolíticos/farmacocinética
Transtornos de Ansiedade/sangue
Transtornos de Ansiedade/psicologia
Biomarcadores/sangue
Relação Dose-Resposta a Droga
Encefalinas/sangue
Feminino
Seguimentos
Seres Humanos
Masculino
Medazepam/administração & dosagem
Medazepam/farmacocinética
Meia-Idade
Neurastenia/sangue
Neurastenia/psicologia
Oligopeptídeos/farmacocinética
Psicometria/métodos
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Biomarkers); 0 (Enkephalins); 0 (Oligopeptides); 0 (TP 7); P0J3387W3S (Medazepam)
[Em] Mês de entrada:0807
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080506
[St] Status:MEDLINE


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[PMID]:15287652
[Au] Autor:Ghosh P; Reddy MM; Rao BS; Sarin RK
[Ad] Endereço:Ministry of Home Affairs, Directorate of Forensic Science, Central Forensic Science Laboratory, Ramanthapur, Hyderabad-500 013, India.
[Ti] Título:Determination of diazepam in cream biscuits by liquid chromatography.
[So] Source:J AOAC Int;87(3):569-72, 2004 May-Jun.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An analytical procedure was developed for the detection and quantitation of diazepam in cream biscuits, which were used to commit crime. The method involves the extraction of diazepam with ethanol at room temperature, and the extract is filtered, evaporated to dryness, and redissolved in the mobile phase, methanol-acetonitrile-tetrahydrofuran-water (15 + 55 + 4 + 26, v/v). The separation is achieved on a C18 reversed-phase column with the mobile phase and diode array detection (lambda(max)) at 230 nm. Medazepam is used as the internal standard is for quantification. The calibration plot for the determination of diazepam is based on linear regression analysis (y = 0.6687x + 0.0372; r2 = 0.995). The limit of detection for diazepam in the biscuit samples was estimated as 600 ng/mL. The limit of quantitation for diazepam was estimated as 1.75 microg/mL. The diazepam detected per piece of biscuit was found to be in the range of 0.27-0.45 mg. Pure diazepam was added to biscuit samples at 3 levels (100 and 500 microg/g, and 1 mg/g), and the recoveries were found to be 95%. The mean retention time of diazepam was 2.7 min and that of medazepam (IS) was 4 min. The relative standard deviations of the diazepam level in the biscuit samples were estimated to be 0.4% for retention time and 1.02% for peak area in intraday analysis, whereas the corresponding values were and 0.61 and 2.34% in interday analysis. The method is rapid and reliable for qualitative and quantitative analysis of cream biscuits laced with diazepam, and it can be used by law enforcement laboratories for routine analysis.
[Mh] Termos MeSH primário: Ansiolíticos/análise
Diazepam/análise
Análise de Alimentos
[Mh] Termos MeSH secundário: Cromatografia Líquida
Medicina Legal
Indicadores e Reagentes
Medazepam/análise
Fotometria
Padrões de Referência
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Indicators and Reagents); P0J3387W3S (Medazepam); Q3JTX2Q7TU (Diazepam)
[Em] Mês de entrada:0410
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040804
[St] Status:MEDLINE


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[PMID]:14617856
[Au] Autor:Zevzikoviene A; Zevzikovas A; Bertulis A
[Ad] Endereço:Department of Analytical and Toxicological Chemistry, Kaunas University of Medicine, Kaunas, Lithuania. augusta@kaunas.init.lt
[Ti] Título:[Determination of diazepine derivatives: alprazolam, medazepam, chlordiazepoxid mixture by high performance liquid chromatography].
[Ti] Título:Diazepino dariniu: alprazolamo, medazepamo, chlordiazepoksido misinio tyrimas didelio slegio skysciu chromatografijos metodu..
[So] Source:Medicina (Kaunas);39 Suppl 2:37-41, 2003.
[Is] ISSN:1648-9144
[Cp] País de publicação:Netherlands
[La] Idioma:lit
[Ab] Resumo:The aim of this research was to determine possibility of qualitative analysis of diazepine derivatives: alprazolam, medazepam, chlordiazepoxid in the mixture. The high performance liquid chromatography was used for the investigation, the reagents--tablets of alprazolam, medazepam, chlordiazepoxid. It was found out that the most acceptable eluent for the analysis of the mixture by high pressure liquid chromatography is phosphate buffer, containing 0.02 M penthanesulfonic acid:etannitrile (55:45) (pH=3.5). The optimal wavelength for identification of the drugs in the mixture is 254 nm.
[Mh] Termos MeSH primário: Ansiolíticos/análise
Benzodiazepinas/análise
[Mh] Termos MeSH secundário: Alprazolam/análise
Tampões (Química)
Clordiazepóxido/análise
Cromatografia Líquida de Alta Pressão
Interpretação Estatística de Dados
Medazepam/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Buffers); 12794-10-4 (Benzodiazepines); 6RZ6XEZ3CR (Chlordiazepoxide); P0J3387W3S (Medazepam); YU55MQ3IZY (Alprazolam)
[Em] Mês de entrada:0803
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:031118
[St] Status:MEDLINE


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[PMID]:12949644
[Au] Autor:Molodavkin GM; Voronina TA; Chernyavskaya LI; Burlakova EB; Khorseva NI; Seredenin SB
[Ad] Endereço:Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
[Ti] Título:Pharmacological activity of phenazepam and flunitrazepam in ultralow doses.
[So] Source:Bull Exp Biol Med;135 Suppl 7:39-41, 2003 Jan.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Experiments on male outbred albino rats showed that benzodiazepine tranquilizers phenazepam and flunitrazepam in ultralow doses (10(-9)-10(-15) mol/kg) produced an anxiolytic effect in the conflict situation test. This effect was not accompanied by myorelaxing and sedative side effects typical of standard doses of tranquilizers.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Comportamento Animal/efeitos dos fármacos
Benzodiazepinas/farmacologia
Flunitrazepam/farmacologia
Tranquilizantes/farmacologia
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Masculino
Medazepam/farmacologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Tranquilizing Agents); 12794-10-4 (Benzodiazepines); 3DSB43090Z (phenazepam); 620X0222FQ (Flunitrazepam); P0J3387W3S (Medazepam)
[Em] Mês de entrada:0909
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030902
[St] Status:MEDLINE



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