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Pesquisa : D03.633.100.150.266.450.400.281 [Categoria DeCS]
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[PMID]:28832658
[Au] Autor:Deng XL; Wang Y; Xiao GS
[Ad] Endereço:Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
[Ti] Título:Effects of equol on multiple K+ channels stably expressed in HEK 293 cells.
[So] Source:PLoS One;12(8):e0183708, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study investigated the effects of equol on cardiovascular K+ channel currents. The cardiovascular K+ channel currents were determined in HEK 293 cells stably expressing cloned differential cardiovascular K+ channels with conventional whole-cell patch voltage-clamp technique. We found that equol inhibited hKv1.5 (IC50: 15.3 µM), hKv4.3 (IC50: 29.2 µM and 11.9 µM for hKv4.3 peak current and charge area, respectively), IKs (IC50: 24.7 µM) and IhERG (IC50: 31.6 and 56.5 µM for IhERG.tail and IhERG.step, respectively), but not hKir2.1 current, in a concentration-dependent manner. Interestingly, equol increased BKCa current with an EC50 of 0.1 µM. It had no significant effect on guinea pig ventricular action potentials at concentrations of ≤3 µM. These results demonstrate that equol inhibits several cardiac K+ currents at relatively high concentrations, whereas it increases BKCa current at very low concentrations, suggesting that equol is a safe drug candidate for treating patients with cerebral vascular disorders.
[Mh] Termos MeSH primário: Equol/farmacologia
Canais de Potássio/efeitos dos fármacos
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Animais
Cobaias
Células HEK293
Ventrículos do Coração/efeitos dos fármacos
Seres Humanos
Canais de Potássio/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Potassium Channels); 531-95-3 (Equol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183708


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[PMID]:28768836
[Au] Autor:Horiuchi H; Usami A; Shirai R; Harada N; Ikushiro S; Sakaki T; Nakano Y; Inui H; Yamaji R
[Ad] Endereço:Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences.
[Ti] Título:-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic ß-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing ß-Cell Function in Male Mice.
[So] Source:J Nutr;147(9):1631-1639, 2017 Sep.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:-equol, which is enantioselectively produced from daidzein by gut microbiota, has been suggested as a chemopreventive agent against type 2 diabetes mellitus (T2DM), but the underlying mechanisms remain unclear. We investigated the effects of -equol on pancreatic ß-cell function. ß-Cell growth and insulin secretion were evaluated with male Institute of Cancer Research mice and isolated pancreatic islets from the mice, respectively. The mechanisms by which -equol stimulated ß-cell response were examined in INS-1 ß-cells. The effect of -equol treatment on ß-cell function was assessed in low-dose streptozotocin-treated mice. -equol was used at 10 µmol/L for in vitro and ex vivo studies and was administered by oral gavage (20 mg/kg, 2 times/d throughout the experimental period) for in vivo studies. -equol administration for 7 d increased Ki67-positive ß-cells by 27% ( < 0.01) in mice. -equol enantioselectively enhanced glucose-stimulated insulin secretion in mouse pancreatic islets by 41% ( < 0.001). In INS-1 cells, -equol exerted stronger effects than daidzein on cell growth, insulin secretion, and cAMP-response element (CRE)-mediated transcription. These -equol effects were diminished by inhibiting protein kinase A. The effective concentration of -equol for stimulating cAMP production at the plasma membrane was lower than that for phosphodiesterase inhibition. -equol-stimulated CRE activation was negatively controlled by the knockdown of G-protein α subunit group S (stimulatory) and positively controlled by that of G-protein-coupled receptor kinase-3 and -6. Compared with vehicle-treated controls, -equol gavage treatment resulted in an increase in ß-cell mass of 104% ( < 0.05), a trend toward high plasma insulin concentrations (by 118%; = 0.06), and resistance to hyperglycemia after streptozotocin treatment (78% of AUC after glucose challenge; < 0.01). -equol administration significantly increased the number of Ki67-positive proliferating ß-cells by 62% ( < 0.01) and decreased that of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive apoptotic ß-cells by 75% ( < 0.05). Our results show that -equol boosts ß-cell function and prevents hypoglycemia in mice, suggesting its potential for T2DM prevention.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Membrana Celular/efeitos dos fármacos
AMP Cíclico/metabolismo
Diabetes Mellitus Experimental/tratamento farmacológico
Equol/farmacologia
Células Secretoras de Insulina/efeitos dos fármacos
Insulina/secreção
[Mh] Termos MeSH secundário: Animais
Área Sob a Curva
Crescimento Celular/efeitos dos fármacos
Membrana Celular/metabolismo
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/patologia
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/prevenção & controle
Hiperglicemia/sangue
Hiperglicemia/induzido quimicamente
Hiperglicemia/etiologia
Hiperglicemia/prevenção & controle
Células Secretoras de Insulina/citologia
Células Secretoras de Insulina/metabolismo
Isoflavonas/metabolismo
Isoflavonas/farmacologia
Masculino
Camundongos Endogâmicos ICR
Ratos
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 0 (Isoflavones); 531-95-3 (Equol); 6287WC5J2L (daidzein); E0399OZS9N (Cyclic AMP)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.250860


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[PMID]:28415978
[Au] Autor:Guadamuro L; Dohrmann AB; Tebbe CC; Mayo B; Delgado S
[Ad] Endereço:Department of Microbiology and Biochemistry, Instituto de Productos Lácteos de Asturias (IPLA), Consejo Superior de Investigaciones Científicas (CSIC), Asturias, Spain.
[Ti] Título:Bacterial communities and metabolic activity of faecal cultures from equol producer and non-producer menopausal women under treatment with soy isoflavones.
[So] Source:BMC Microbiol;17(1):93, 2017 Apr 17.
[Is] ISSN:1471-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Isoflavones are polyphenols with estrogenic activity found mainly in soy and soy-derived products that need to be metabolised in the intestine by the gut bacteria to be fully active. There is little knowledge about isoflavone bioconversion and equol production in the human intestine. In this work, we developed an in vitro anaerobic culture model based on faecal slurries to assess the impact of isoflavone supplementation on the overall intestinal bacterial composition changes and associated metabolic transformations. RESULTS: In the faecal anaerobic batch cultures of this study bioconversion of isoflavones into equol was possible, suggesting the presence of viable equol-producing bacterial taxa within the faeces of menopausal women with an equol producer phenotype. The application of high-throughput DNA sequencing of 16S rRNA gene amplicons revealed the composition of the faecal cultures to be modified by the addition of isoflavones, with enrichment of some bacterial gut members associated with the metabolism of phenolics and/or equol production, such as Collinsella, Faecalibacterium and members of the Clostridium clusters IV and XIVa. In addition, the concentration of short-chain fatty acids (SCFAs) detected in the isoflavone-containing faecal cultures was higher in those inoculated with faecal slurries from equol-producing women. CONCLUSIONS: This study constitutes the first step in the development of a faecal culturing system with isoflavones that would further allow the selection and isolation of intestinal bacterial types able to metabolize these compounds and produce equol in vitro. Although limited by the low number of faecal cultures analysed and the inter-individual bacterial diversity, the in vitro results obtained in this work tend to indicate that soy isoflavones might provide an alternative energy source for the increase of equol-producing taxa and enhancement of SCFAs production. SCFAs and equol are both considered pivotal bacterial metabolites in the triggering of intestinal health-related beneficial effects.
[Mh] Termos MeSH primário: Bactérias/classificação
Bactérias/metabolismo
Biota
Equol/metabolismo
Fezes/microbiologia
Isoflavonas/metabolismo
Fitoestrógenos/metabolismo
[Mh] Termos MeSH secundário: Anaerobiose
Bactérias/genética
Bactérias/crescimento & desenvolvimento
Biotransformação
Análise por Conglomerados
DNA Bacteriano/química
DNA Bacteriano/genética
DNA Ribossômico/química
DNA Ribossômico/genética
Ácidos Graxos Voláteis/metabolismo
Feminino
Seres Humanos
Menopausa
Modelos Biológicos
Filogenia
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (Fatty Acids, Volatile); 0 (Isoflavones); 0 (Phytoestrogens); 0 (RNA, Ribosomal, 16S); 531-95-3 (Equol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1186/s12866-017-1001-y


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[PMID]:28364866
[Au] Autor:Miller LM; Lampe JW; Newton KM; Gundersen G; Fuller S; Reed SD; Frankenfeld CL
[Ad] Endereço:Department of Global and Community Health, George Mason University Fairfax, VA, United States.
[Ti] Título:Being overweight or obese is associated with harboring a gut microbial community not capable of metabolizing the soy isoflavone daidzein to O-desmethylangolensin in peri- and post-menopausal women.
[So] Source:Maturitas;99:37-42, 2017 May.
[Is] ISSN:1873-4111
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Obesity can be a considerable health concern for peri- and post-menopausal women. Evidence suggests an association between the gut microbiome and obesity. The study objective was to evaluate the association between being overweight or obese and phenotypic markers of having an overall gut microbial environment not capable of metabolizing the isoflavone daidzein to equol or O-desmethylangolensin (ODMA). STUDY DESIGN: Cross-sectional study of 137 peri- and 218 post-menopausal women, aged 44-55 years, who consumed at least three servings per week of soy (source of daidzein). Equol and ODMA producers and non-producers were identified based on urinary concentrations of daidzein, equol and ODMA in a 24-h urine sample. MAIN OUTCOME MEASURES: Mean body mass index (BMI) and odds of obesity. RESULTS: Fifty-one women were ODMA non-producers and 226 were equol non-producers. The ODMA non-producer phenotype was positively associated with obesity (OR: 3.33, 95% CI: 1.53, 7.23), and mean BMI was significantly higher in non-producers (28.9kg/m ) than in producers (26.7kg/m ), after adjusting for age, ethnicity, and menopausal status. Positive associations with being obese were observed in both peri-menopausal (OR=3.92, 95% CI: 0.90, 17.0) and post-menopausal (OR=3.00, 95% CI: 1.22, 7.70) women. The equol non-producer phenotype was not associated with obesity (OR=1.13, 95% CI: 0.64, 1.98), and mean BMI was not significantly different between equol producers (27.3kg/m ) and non-producers (26.5kg/m ). CONCLUSIONS: These results suggest that the ODMA non-producer phenotype is associated with obesity in peri- and post-menopausal women. Further work is needed to confirm these observations in additional populations and to evaluate possible mechanisms.
[Mh] Termos MeSH primário: Equol/biossíntese
Microbioma Gastrointestinal/fisiologia
Isoflavonas/biossíntese
Isoflavonas/metabolismo
Obesidade/microbiologia
[Mh] Termos MeSH secundário: Adulto
Índice de Massa Corporal
Estudos Transversais
Equol/urina
Grupos Étnicos
Feminino
Seres Humanos
Isoflavonas/urina
Meia-Idade
Obesidade/epidemiologia
Razão de Chances
Sobrepeso/epidemiologia
Sobrepeso/microbiologia
Perimenopausa
Pós-Menopausa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isoflavones); 531-95-3 (Equol); 6287WC5J2L (daidzein); SCY1S10OK4 (O-desmethylangolensin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE


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[PMID]:28355308
[Au] Autor:Araya-Cloutier C; Martens B; Schaftenaar G; Leipoldt F; Gruppen H; Vincken JP
[Ad] Endereço:Laboratory of Food Chemistry, Wageningen University, Wageningen, The Netherlands.
[Ti] Título:Structural basis for non-genuine phenolic acceptor substrate specificity of Streptomyces roseochromogenes prenyltransferase CloQ from the ABBA/PT-barrel superfamily.
[So] Source:PLoS One;12(3):e0174665, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acceptor substrate specificity of Streptomyces roseochromogenes prenyltransferase SrCloQ was investigated using different non-genuine phenolic compounds. RP-UHPLC-UV-MSn was used for the tentative annotation and quantification of the prenylated products. Flavonoids, isoflavonoids and stilbenoids with different types of substitution were prenylated by SrCloQ, although with less efficiency than the genuine substrate 4-hydroxyphenylpyruvate. The isoflavan equol, followed by the flavone 7,4'-dihydroxyflavone, were the best non-genuine acceptor substrates. B-ring C-prenylation was in general preferred over A-ring C-prenylation (ratio 5:1). Docking studies of non-genuine acceptor substrates with the B-ring oriented towards the donor substrate dimethylallyl pyrophosphate, showed that the carbonyl group of the C-ring was able to make stabilizing interactions with the residue Arg160, which might determine the preference observed for B-ring prenylation. No reaction products were formed when the acceptor substrate had no phenolic hydroxyl groups. This preference can be explained by the essential hydrogen bond needed between a phenolic hydroxyl group and the residue Glu281. Acceptor substrates with an additional hydroxyl group at the C3' position (B-ring), were mainly O3'-prenylated (> 80% of the reaction products). This can be explained by the proximity of the C3' hydroxyl group to the donor substrate at the catalytic site. Flavones were preferred over isoflavones by SrCloQ. Docking studies suggested that the orientation of the B-ring and of the phenolic hydroxyl group at position C7 (A-ring) of flavones towards the residue Tyr233 plays an important role in this observed preference. Finally, the insights obtained on acceptor substrate specificity and regioselectivity for SrCloQ were extended to other prenyltransferases from the CloQ/NhpB family.
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Dimetilaliltranstransferase/metabolismo
Flavonoides/metabolismo
Isoflavonas/metabolismo
Streptomyces/enzimologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/química
Domínio Catalítico
Dimetilaliltranstransferase/química
Equol/química
Equol/metabolismo
Flavonoides/química
Ligações de Hidrogênio
Isoflavonas/química
Cinética
Simulação de Acoplamento Molecular
Estrutura Molecular
Novobiocina/análogos & derivados
Novobiocina/biossíntese
Novobiocina/química
Fenóis/química
Fenóis/metabolismo
Ácidos Fenilpirúvicos/química
Ácidos Fenilpirúvicos/metabolismo
Prenilação
Ligação Proteica
Estrutura Terciária de Proteína
Estilbenos/química
Estilbenos/metabolismo
Streptomyces/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Flavonoids); 0 (Isoflavones); 0 (Phenols); 0 (Phenylpyruvic Acids); 0 (Stilbenes); 156-39-8 (4-hydroxyphenylpyruvic acid); 17EC19951N (Novobiocin); 39868-96-7 (clorobiocin); 531-95-3 (Equol); EC 2.5.1.1 (Dimethylallyltranstransferase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174665


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[PMID]:28297748
[Au] Autor:Lee NK; Paik HD
[Ad] Endereço:Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea.
[Ti] Título:Bioconversion Using Lactic Acid Bacteria: Ginsenosides, GABA, and Phenolic Compounds.
[So] Source:J Microbiol Biotechnol;27(5):869-877, 2017 May 28.
[Is] ISSN:1738-8872
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Lactic acid bacteria (LAB) are used as fermentation starters in vegetable and dairy products and influence the pH and flavors of foods. For many centuries, LAB have been used to manufacture fermented foods; therefore, they are generally regarded as safe. LAB produce various substances, such as lactic acid, ß-glucosidase, and ß-galactosidase, making them useful as fermentation starters. Existing functional substances have been assessed as fermentation substrates for better component bioavailability or other functions. Representative materials that were bioconverted using LAB have been reported and include minor ginsenosides, γ-aminobutyric acid, equol, aglycones, bioactive isoflavones, genistein, and daidzein, among others. Fermentation mainly involves polyphenol and polysaccharide substrates and is conducted using bacterial strains such as and sp. In this review, we summarize recent studies of bioconversion using LAB and discuss future directions for this field.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Ginsenosídeos/metabolismo
Ácido Láctico/metabolismo
Fenóis/metabolismo
Ácido gama-Aminobutírico/metabolismo
[Mh] Termos MeSH secundário: Bactérias/enzimologia
Bifidobacterium/metabolismo
Produtos Fermentados do Leite
Equol/metabolismo
Fermentação
Microbiologia de Alimentos
Genisteína/metabolismo
Isoflavonas/metabolismo
Lactobacillus/metabolismo
Lactobacillus plantarum/metabolismo
Streptococcus thermophilus/metabolismo
beta-Galactosidase/metabolismo
beta-Glucosidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ginsenosides); 0 (Isoflavones); 0 (Phenols); 33X04XA5AT (Lactic Acid); 531-95-3 (Equol); 56-12-2 (gamma-Aminobutyric Acid); 6287WC5J2L (daidzein); DH2M523P0H (Genistein); EC 3.2.1.21 (beta-Glucosidase); EC 3.2.1.23 (beta-Galactosidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.4014/jmb.1612.12005


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[PMID]:28264445
[Au] Autor:Subedi L; Ji E; Shin D; Jin J; Yeo JH; Kim SY
[Ad] Endereço:College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Korea. subedilali@gmail.com.
[Ti] Título:Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro.
[So] Source:Nutrients;9(3), 2017 Feb 27.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Estrogen deficiency has been well characterized in inflammatory disorders including neuroinflammation. Daidzein, a dietary alternative phytoestrogen found in soy (Glycine max) as primary isoflavones, possess anti-inflammatory activity, but the effect of its active metabolite Equol (7-hydroxy-3-(4'-hydroxyphenyl)-chroman) has not been well established. In this study, we investigated the anti-neuroinflammatory and neuroprotective effect of Equol in vitro. To evaluate the potential effects of Equol, three major types of central nervous system (CNS) cells, including microglia (BV-2), astrocytes (C6), and neurons (N2a), were used. Effects of Equol on the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), Mitogen activated protein kinase (MAPK) signaling proteins, and apoptosis-related proteins were measured by western blot analysis. Equol inhibited the lipopolysaccharide (LPS)-induced TLR4 activation, MAPK activation, NF-kB-mediated transcription of inflammatory mediators, production of nitric oxide (NO), release of prostaglandin E2 (PGE-2), secretion of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), in Lipopolysaccharide (LPS)-activated murine microglia cells. Additionally, Equol protects neurons from neuroinflammatory injury mediated by LPS-activated microglia through downregulation of neuronal apoptosis, increased neurite outgrowth in N2a cell and neurotrophins like nerve growth factor (NGF) production through astrocytes further supporting its neuroprotective potential. These findings provide novel insight into the anti-neuroinflammatory effects of Equol on microglial cells, which may have clinical significance in cases of neurodegeneration.
[Mh] Termos MeSH primário: Equol/farmacologia
Isoflavonas/farmacologia
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Astrócitos/citologia
Astrócitos/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Sistema Nervoso Central/citologia
Sistema Nervoso Central/efeitos dos fármacos
Sistema Nervoso Central/metabolismo
Ciclo-Oxigenase 2/genética
Ciclo-Oxigenase 2/metabolismo
Dinoprostona/metabolismo
Regulação para Baixo
Interleucina-6/metabolismo
Lipopolissacarídeos/toxicidade
Camundongos
Microglia/citologia
Microglia/efeitos dos fármacos
Proteínas Quinases Ativadas por Mitógeno/genética
Proteínas Quinases Ativadas por Mitógeno/metabolismo
NF-kappa B/genética
NF-kappa B/metabolismo
Neurônios/citologia
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Neuroproteção
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Ratos
Receptor 4 Toll-Like/genética
Receptor 4 Toll-Like/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); 0 (Isoflavones); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Neuroprotective Agents); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 4); 0 (Tumor Necrosis Factor-alpha); 31C4KY9ESH (Nitric Oxide); 531-95-3 (Equol); 6287WC5J2L (daidzein); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2); EC 2.7.11.24 (Mitogen-Activated Protein Kinases); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28205492
[Au] Autor:Ahuja V; Miura K; Vishnu A; Fujiyoshi A; Evans R; Zaid M; Miyagawa N; Hisamatsu T; Kadota A; Okamura T; Ueshima H; Sekikawa A
[Ad] Endereço:1Department of Epidemiology,Graduate School of Public Health,University of Pittsburgh,Pittsburgh,PA 15260,USA.
[Ti] Título:Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men.
[So] Source:Br J Nutr;117(2):260-266, 2017 Jan.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Equol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40-49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors. Equol-producers were classified as individuals having a serum level of equol >83 nm. The presence of CAC was defined as a coronary Ca score ≥10 Agatston units. The associations of dietary isoflavones and equol-producers with CAC were analysed using multiple logistic regression. The median of dietary isoflavones, equol and CAC were 512·7 (interquartile range (IQR) 194·1, 1170·0), 9·1 (IQR 0·10, 33·1) and 0·0 (IQR 0·0, 1·0) nm, respectively. Prevalence of CAC and equol-producers was 9·6 and 16·0 %, respectively. Dietary isoflavones were not significantly associated with CAC. After multivariable adjustment, the OR for the presence of CAC in equol-producers compared with equol non-producers was 0·10 (95 % CI 0·01, 0·90, P<0·04). Equol-producers had significantly lower CAC than equol non-producers, but there was no significant association between dietary isoflavones and CAC, suggesting that equol may be a key factor for atheroprotective properties of isoflavones in Japanese men. This finding must be confirmed in larger studies or clinical trials of equol that is now available as a dietary supplement.
[Mh] Termos MeSH primário: Aterosclerose/metabolismo
Calcinose
Vasos Coronários/patologia
Dieta
Equol/metabolismo
Isoflavonas/farmacologia
[Mh] Termos MeSH secundário: Adulto
Aterosclerose/etiologia
Aterosclerose/prevenção & controle
Bactérias/metabolismo
Biomarcadores/metabolismo
Calcinose/etiologia
Calcinose/prevenção & controle
Vasos Coronários/efeitos dos fármacos
Vasos Coronários/metabolismo
Estudos Transversais
Equol/sangue
Seres Humanos
Isoflavonas/sangue
Isoflavonas/metabolismo
Isoflavonas/uso terapêutico
Japão
Modelos Logísticos
Masculino
Meia-Idade
Razão de Chances
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Isoflavones); 531-95-3 (Equol); 6287WC5J2L (daidzein)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1017/S000711451600458X


  9 / 514 MEDLINE  
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[PMID]:28041599
[Au] Autor:Davinelli S; Scapagnini G; Marzatico F; Nobile V; Ferrara N; Corbi G
[Ad] Endereço:Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy. Electronic address: sergio.davinelli@unimol.it.
[Ti] Título:Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study.
[So] Source:Maturitas;96:77-83, 2017 Feb.
[Is] ISSN:1873-4111
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study was designed to evaluate the effects of equol and resveratrol supplementation on health-related quality of life (HRQoL) in otherwise healthy menopausal women with hot flashes, anxiety and depressive symptoms. METHODS: Sixty recently menopausal women aged 50-55 years were randomized in a 12-week, placebo-controlled trial to receive 200mg of fermented soy containing 10mg of equol and 25mg of resveratrol (1 tablet/day). The primary outcome was the change in score on the Menopause Rating Scale (MRS), used to evaluate the severity of age-/menopause-related complaints. Additional outcome measures included the subject-reported score on the Hamilton Rating Scale for Depression (HAM-D) and Nottingham Health Profile (NHP), which was used specifically to assess sleep quality. RESULTS: The symptoms assessed by the MRS improved during treatment in the active group. Comparison between placebo and treatment groups revealed statistically significant improvement in particular for dryness of vagina (-85.7%) (p<0.001), heart discomfort (-78.8%; p<0.001) and sexual problems (-73.3%; p<0.001). On the HAM-D significant improvements at week 12 were seen in work and activities (-94.1%) (p<0.001). Subjects treated with equol and resveratrol also had significant differences in the sleep domain of the NHP (p<0.001). CONCLUSION: These findings provide evidence that 12 weeks of dietary supplementation with equol and resveratrol may improve menopause-related quality of life in healthy women.
[Mh] Termos MeSH primário: Equol/uso terapêutico
Menopausa/efeitos dos fármacos
Fitoestrógenos/uso terapêutico
Qualidade de Vida
Estilbenos/uso terapêutico
[Mh] Termos MeSH secundário: Ansiedade/etiologia
Depressão/etiologia
Suplementos Nutricionais
Método Duplo-Cego
Combinação de Medicamentos
Feminino
Fogachos/tratamento farmacológico
Seres Humanos
Menopausa/psicologia
Meia-Idade
Disfunções Sexuais Fisiológicas/tratamento farmacológico
Sono/efeitos dos fármacos
Resultado do Tratamento
Vagina/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Phytoestrogens); 0 (Stilbenes); 531-95-3 (Equol); Q369O8926L (resveratrol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


  10 / 514 MEDLINE  
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[PMID]:28041561
[Au] Autor:Kasparovská J; Dadáková K; Lochman J; Hadrová S; Krízová L; Kasparovský T
[Ad] Endereço:Masaryk University, Kotlarska 2, 61137 Brno, Czech Republic.
[Ti] Título:Changes in equol and major soybean isoflavone contents during processing and storage of yogurts made from control or isoflavone-enriched bovine milk determined using LC-MS (TOF) analysis.
[So] Source:Food Chem;222:67-73, 2017 May 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of supplementing a basal diet for dairy cows with "Soybean extract 40" (Biomedica, Prague, Czech Republic), containing 40% soybean isoflavones, on the contents of daidzein, glycitein, genistein, and equol in milk as well as fresh and mature yogurts was estimated. To determine the contents of these isoflavonoids, an efficient analytical LC-MS (TOF) technique was used. The "Soybean extract 40" used in our study contained an especially high proportion of daidzein (307gkg ). In both milk and yogurt samples, the amounts of daidzein and its metabolite equol were significantly higher in samples obtained from cows that received the isoflavone extract-supplemented diet than from those that received the basal diet, as the precursor daidzein contributed to the increased equol concentrations. Fermentation caused significant changes in the daidzein and glycitein concentrations. With maturation, the concentrations of daidzein and equol were unaffected, while the glycitein concentration decreased significantly.
[Mh] Termos MeSH primário: Equol/análise
Isoflavonas/análise
Iogurte/análise
[Mh] Termos MeSH secundário: Animais
Bovinos
Cromatografia Líquida
Espectrometria de Massas
Leite/química
Feijão de Soja/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isoflavones); 531-95-3 (Equol); 6287WC5J2L (daidzein); 92M5F28TVF (glycitein)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE



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