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[PMID]:28194658
[Au] Autor:Esquivel AO; Sherman SS; Bir CA; Lemos SE
[Ad] Endereço:Department of Mechanical Engineering, College of Engineering and Computer Science, University of Michigan - Dearborn, 4901 Evergreen Road, 2074 IAVS, Dearborn, MI, 48128, USA. aoe@umich.edu.
[Ti] Título:The Interaction of Intramuscular Ketorolac (Toradol) and Concussion in a Rat Model.
[So] Source:Ann Biomed Eng;45(6):1581-1588, 2017 Jun.
[Is] ISSN:1573-9686
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to examine the interaction of a single dose of Toradol and head impact in an in vivo rat model for sport-related concussion using a validated rat concussion model. Thirty-five Sprague-Dawley rats were placed into one of four groups: (1) Control, (2) Impact Only, (3) Toradol Only, (4) Impact and Toradol. Animals in the impact groups were subjected to a single head impact. Animals in the Toradol group received a single intramuscular injection of Toradol prior to impact. We examined magnetic resonance imaging, serum S100-B and cognitive function using a Morris Water Maze. In the control group, latency decreased significantly from day 0 (74.9 s) to 24 h (57.4 s) after anesthesia. There was no statistically significant difference between time zero and 24 h after impact in the Impact only or Impact and Toradol group. Our findings indicate that there were no differences between cognitive ability, MRI findings or S100B in rats that were administered a single dose of Toradol and subjected to a single impact and rats that were subjected to a single impact only. In both impact groups there were transient changes in cognitive ability as measured by the Morris Water Maze.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico
Concussão Encefálica/tratamento farmacológico
Cetorolaco de Trometamina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Concussão Encefálica/sangue
Concussão Encefálica/diagnóstico por imagem
Cognição/efeitos dos fármacos
Injeções Intramusculares
Imagem por Ressonância Magnética
Masculino
Aprendizagem em Labirinto
Ratos Sprague-Dawley
Subunidade beta da Proteína Ligante de Cálcio S100/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (S100 Calcium Binding Protein beta Subunit); 4EVE5946BQ (Ketorolac Tromethamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1007/s10439-017-1809-5


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[PMID]:28126392
[Au] Autor:M A Fathalla Z; Vangala A; Longman M; Khaled KA; Hussein AK; El-Garhy OH; Alany RG
[Ad] Endereço:Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minya, Egypt; School of Pharmacy and Chemistry, Faculty of Science, Engineering & Computing, Kingston University, London, UK.
[Ti] Título:Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations: Design, characterisation, toxicity and transcorneal permeation studies.
[So] Source:Eur J Pharm Biopharm;114:119-134, 2017 May.
[Is] ISSN:1873-3441
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study was aimed at preparing, characterising and evaluating in situ gel formulations based on a blend of two hydrophilic polymers i.e. poloxamer 407 (P407) and poloxamer 188 (P188) for a sustained ocular delivery of ketorolac tromethamine (KT). Drug-polymer interaction studies were performed using DSC and FT-IR. The gelation temperature (T ), gelation time, rheological behaviour, mucoadhesive characteristics of these gels, transcorneal permeation and ocular irritation as well as toxicity was investigated. DSC and FT-IR studies revealed that there may be electrostatic interactions between the drug and the polymers used. P188 modified the T of P407 bringing it close to eye temperature (35°C) compared with the formulation containing P407 alone. Moreover, gels that comprised P407 and P188 exhibited a pseudoplastic behaviour at different concentrations. Furthermore, mucoadhesion study using mucin discs showed that in situ gel formulations have good mucoadhesive characteristics upon increasing the concentration of P407. When comparing formulations PP11 and PP12, the work of adhesion decreased significantly (P<0.001) from 377.9±7.79mNmm to 272.3±6.11mNmm. In vitro release and ex vivo permeation experiments indicated that the in situ gels were able to prolong and control KT release as only 48% of the KT released within 12h. In addition, the HET-CAM and BCOP tests confirmed the non-irritancy of KT loaded in situ gels, and HET-CAM test demonstrated the ability of ocular protection against strongly irritant substances. MTT assay on primary corneal epithelial cells revealed that in situ gel formulations loaded with KT showed reasonable and acceptable percent cell viability compared with control samples.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/administração & dosagem
Anti-Inflamatórios não Esteroides/farmacocinética
Cetorolaco de Trometamina/administração & dosagem
Cetorolaco de Trometamina/farmacocinética
Poloxâmero/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/efeitos adversos
Bovinos
Córnea/efeitos dos fármacos
Composição de Medicamentos
Excipientes
Géis
Cetorolaco de Trometamina/efeitos adversos
Absorção Cutânea
Temperatura Ambiente
Adesivos Teciduais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Excipients); 0 (Gels); 0 (Tissue Adhesives); 106392-12-5 (Poloxamer); 4EVE5946BQ (Ketorolac Tromethamine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE


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[PMID]:27968707
[Au] Autor:Kulo A; Smits A; Maleskic S; Van de Velde M; Van Calsteren K; De Hoon J; Verbesselt R; Deprest J; Allegaert K
[Ad] Endereço:Center for Clinical Pharmacology, KU Leuven and University Hospitals Leuven, Leuven, Belgium; Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina. aida.kulo@mf.unsa.ba.
[Ti] Título:Enantiomer-specific ketorolac pharmacokinetics in young women, including pregnancy and postpartum period.
[So] Source:Bosn J Basic Med Sci;17(1):54-60, 2017 Feb 21.
[Is] ISSN:1840-4812
[Cp] País de publicação:Bosnia and Herzegovina
[La] Idioma:eng
[Ab] Resumo:Racemic ketorolac clearance (CL) is significantly higher at delivery, but S-ketorolac disposition determines the analgesic effects. The aim of this study was to investigate the effect of pregnancy and postpartum period on enantiomer-specific (S and R) intravenous (IV) ketorolac pharmacokinetics (PKs). Data in women shortly following cesarean delivery (n=39) were pooled with data in a subgroup of these women that was reevaluated in the later postpartum period (postpartum group, n=8/39) and with eight healthy female volunteers. All women received single IV bolus of 30 mg ketorolac tromethamine. Five plasma samples were collected at 1, 2, 4, 6, and 8 hours and plasma concentrations were determined using high performance liquid chromatography. Enantiomer-specific PKs were calculated using PKSolver. Unpaired analysis showed that distribution volume at steady state (Vss, L/kg) for S- and R-ketorolac was significantly higher in women shortly following cesarean delivery (n=31) compared to postpartum group (n=8) or to healthy female volunteers (n=8). CL, CL to body weight, and CL to body surface area (CL/BSA) for S- and R-ketorolac were also significantly higher in women following delivery. In addition, S/R-ketorolac CL/BSA ratio was significantly higher at delivery. Paired PK analysis in eight women shortly following delivery and in postpartum group showed the same pattern. Finally, the simultaneous increase in CL and Vss resulted in similar estimates for elimination half-life in both unpaired and paired analysis. In conclusion, pregnancy affects S-, R-, and S/R-ketorolac disposition. This is of clinical relevance since S-ketorolac (analgesia) CL is even more increased compared to R-ketorolac CL, and S/R-ketorolac CL ratio is higher following delivery compared to postpartum period or to healthy female volunteers.
[Mh] Termos MeSH primário: Cetorolaco de Trometamina/farmacocinética
Cetorolaco/farmacocinética
Período Pós-Parto
[Mh] Termos MeSH secundário: Administração Intravenosa
Adulto
Anti-Inflamatórios não Esteroides/administração & dosagem
Peso Corporal
Estudos de Casos e Controles
Cesárea
Cromatografia Líquida de Alta Pressão
Estudos de Coortes
Feminino
Voluntários Saudáveis
Seres Humanos
Injeções Intravenosas
Cetorolaco/sangue
Cetorolaco de Trometamina/sangue
Gravidez
Estereoisomerismo
Fatores de Tempo
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 4EVE5946BQ (Ketorolac Tromethamine); YZI5105V0L (Ketorolac)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE
[do] DOI:10.17305/bjbms.2016.1515


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[PMID]:28025646
[Au] Autor:Yang HL; Liu FC; Tsai SC; Tsay PK; Lin HT; Liu HE
[Ad] Endereço:Department of Nursing, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
[Ti] Título:Ketorolac Tromethamine Spray Prevents Postendotracheal-Intubation-Induced Sore Throat after General Anesthesia.
[So] Source:Biomed Res Int;2016:4582439, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:. Postoperative sore throat is one of the major complaints of general anesthesia in the postanesthesia care unit. This prospective study investigated the preventive effect of ketorolac tromethamine spray in postendotracheal-intubation-induced sore throat after general anesthesia. . Surgical patients undergoing general anesthesia with endotracheal intubation were recruited from a medical center. Patients were randomly assigned to group K (treated with 5% ketorolac tromethamine spray) or group D (treated with distilled water spray). Before intubation, each endotracheal tube was sprayed with the appropriate solution by physicians over the 20 cm length of the cuff. Each group comprised 95 patients fitting the inclusion and exclusion criteria for whom complete data sets were collected. The intensity of the sore throat was measured at 1, 3, 6, and 24 h after surgery, and data were compared. . The two groups had similar characteristics. Postoperative sore throat was significantly less frequent in group K than in group D ( < 0.001) and the pain intensity was significantly lower in group K than in group D at each time point (all < 0.001). . This study demonstrated that preanesthesia 5% ketorolac tromethamine spray could effectively decrease postendotracheal-intubation-induced sore throat in patients undergoing general anesthesia.
[Mh] Termos MeSH primário: Anestesia Geral/efeitos adversos
Intubação Intratraqueal/efeitos adversos
Cetorolaco de Trometamina/administração & dosagem
Sprays Orais
Faringite/prevenção & controle
Complicações Pós-Operatórias/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Faringite/etiologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oral Sprays); 4EVE5946BQ (Ketorolac Tromethamine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1155/2016/4582439


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[PMID]:27522949
[Au] Autor:Elfatatry HM; Mabrouk MM; Hammad SF; Mansour FR; Kamal AH; Alahmad S
[Ad] Endereço:Tanta University, Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, Tanta, Egypt 31111.
[Ti] Título:Development and Validation of Chemometric-Assisted Spectrophotometric Methods for Simultaneous Determination of Phenylephrine Hydrochloride and Ketorolac Tromethamine in Binary Combinations.
[So] Source:J AOAC Int;99(5):1247-51, 2016 Sep.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present work describes new spectrophotometric methods for the simultaneous determination of phenylephrine hydrochloride and ketorolac tromethamine in their synthetic mixtures. The applied chemometric techniques are multivariate methods including classical least squares, principal component regression, and partial least squares. In these techniques, the concentration data matrix was prepared by using the synthetic mixtures containing these drugs dissolved in distilled water. The absorbance data matrix corresponding to the concentration data was obtained by measuring the absorbances at 16 wavelengths in the range 244-274 nm at 2 nm intervals in the zero-order spectra. The spectrophotometric procedures do not require any separation steps. The accuracy, precision, and linearity ranges of the methods have been determined, and analyzing synthetic mixtures containing the studied drugs has validated them. The developed methods were successfully applied to the synthetic mixtures and the results were compared to those obtained by a reported HPLC method.
[Mh] Termos MeSH primário: Cetorolaco de Trometamina/análise
Fenilefrina/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Análise dos Mínimos Quadrados
Análise de Componente Principal
Software
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
1WS297W6MV (Phenylephrine); 4EVE5946BQ (Ketorolac Tromethamine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160816
[St] Status:MEDLINE
[do] DOI:10.5740/jaoacint.16-0106


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[PMID]:27380104
[Au] Autor:Kim JS; Lee J; Soh EY; Ahn H; Oh SE; Lee JD; Joe HB
[Ad] Endereço:From the *Department of Anesthesiology and Pain Medicine, †Department of Surgery, and ‡Office of Biostatistics, Ajou University School of Medicine, Suwon, Republic of Korea.
[Ti] Título:Analgesic Effects of Ultrasound-Guided Serratus-Intercostal Plane Block and Ultrasound-Guided Intermediate Cervical Plexus Block After Single-Incision Transaxillary Robotic Thyroidectomy: A Prospective, Randomized, Controlled Trial.
[So] Source:Reg Anesth Pain Med;41(5):584-8, 2016 Sep-Oct.
[Is] ISSN:1532-8651
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Single-incision transaxillary robotic thyroidectomy (START) requires substantial tissue disruption, which produces moderate-to-severe pain in the axilla and neck areas during the early postoperative period. This study aimed to investigate the analgesic effects of ultrasound-guided serratus-intercostal plane blocks and intermediate cervical plexus blocks (CPBs) on the early postoperative pain after START. METHODS: We randomized 22 patients to undergo either ultrasound-guided serratus-intercostal plane and intermediate CPBs (the block group, n = 11) or to not undergo any block (the control group, n = 11). We compared postoperative axillary pain, postoperative neck pain, and analgesic use between the groups during the first 24 hours. The rescue analgesics were intravenous fentanyl (0.5 µg/kg) in the postanesthesia care unit, and intravenous ketorolac tromethamine (30 mg) in the general ward. RESULTS: The block group showed consistently lower pain scores than the control group in the axillary area in the first 24 hours and in the neck area only in the first 3 hours after surgery. The numbers (proportions) of patients who required analgesics were 11 (100%) in the control group and 6 (54.5%) in the block group during the first 24 hours (P = 0.035). No adverse effect was observed related to the peripheral nerve blocks. CONCLUSIONS: After START, a serratus-intercostal plane block performed at the level of the third rib was an effective analgesic technique for axillary pain; however, the clinical effectiveness of intermediate CPB for neck pain may be limited.
[Mh] Termos MeSH primário: Bloqueio do Plexo Cervical
Cervicalgia/prevenção & controle
Bloqueio Nervoso/métodos
Dor Pós-Operatória/prevenção & controle
Procedimentos Cirúrgicos Robóticos/efeitos adversos
Tireoidectomia/efeitos adversos
Ultrassonografia de Intervenção
[Mh] Termos MeSH secundário: Adulto
Analgésicos Opioides/administração & dosagem
Bloqueio do Plexo Cervical/efeitos adversos
Inibidores de Ciclo-Oxigenase/administração & dosagem
Feminino
Seres Humanos
Cetorolaco de Trometamina/administração & dosagem
Masculino
Meia-Idade
Cervicalgia/diagnóstico
Cervicalgia/etiologia
Bloqueio Nervoso/efeitos adversos
Medição da Dor
Dor Pós-Operatória/diagnóstico
Dor Pós-Operatória/etiologia
Estudos Prospectivos
República da Coreia
Tireoidectomia/métodos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Cyclooxygenase Inhibitors); 4EVE5946BQ (Ketorolac Tromethamine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160706
[St] Status:MEDLINE
[do] DOI:10.1097/AAP.0000000000000430


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[PMID]:27091293
[Au] Autor:Morsi N; Ghorab D; Refai H; Teba H
[Ad] Endereço:Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
[Ti] Título:Ketoroloac tromethamine loaded nanodispersion incorporated into thermosensitive in situ gel for prolonged ocular delivery.
[So] Source:Int J Pharm;506(1-2):57-67, 2016 Jun 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study was designed to improve the ocular availability of ketorolac tromethamine and to prolong its precorneal residence time for the treatment of postoperative ocular inflammation. Ketorolac tromethamine nanodispersions were successfully prepared by nanoprecipitation method using Eudragit(®) RL100. These nanodispersions were characterized in terms of particle size, zeta potential, entrapment efficiency and in vitro release. Consequently, the optimum nanodispersion was incorporated into thermosensitive in situ gel. The optimum gelling capacity was obtained by 20% Pluronic(®) F-127 and 14% Pluronic(®) F-127/1.5% HPMC K4m. The gelling temperature and gelation time of the in situ gels increased by decreasing the concentration of Pluronic(®) F-127. The mucoadhesive strength was significantly improved by the addition of HPMC. Incorporation of ketorolac tromethamine loaded nanodispersions into in situ gel bases sustained the release of ketorolac tromethamine, improved its ocular availability and prolonged its residence time without causing irritation to eye.
[Mh] Termos MeSH primário: Preparações de Ação Retardada/química
Olho/efeitos dos fármacos
Géis/administração & dosagem
Géis/química
Cetorolaco de Trometamina/administração & dosagem
Cetorolaco de Trometamina/química
Nanopartículas/química
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Química Farmacêutica/métodos
Preparações de Ação Retardada/administração & dosagem
Preparações de Ação Retardada/metabolismo
Portadores de Fármacos/química
Sistemas de Liberação de Medicamentos/métodos
Géis/metabolismo
Cetorolaco de Trometamina/metabolismo
Lactose/análogos & derivados
Lactose/química
Metilcelulose/análogos & derivados
Metilcelulose/química
Nanopartículas/administração & dosagem
Tamanho da Partícula
Poloxâmero/química
Coelhos
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Drug Carriers); 0 (Gels); 0 (hydroxypropylmethylcellulose-lactose matrix); 106392-12-5 (Poloxamer); 4EVE5946BQ (Ketorolac Tromethamine); 9004-67-5 (Methylcellulose); J2B2A4N98G (Lactose)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE


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[PMID]:26895689
[Au] Autor:Belal TS; El-Kafrawy DS; Mahrous MS; Abdel-Khalek MM; Abo-Gharam AH
[Ad] Endereço:University of Alexandria, Faculty of Pharmacy, Pharmaceutical Analytical Chemistry Department, Elmessalah, Alexandria 21521, Egypt. Electronic address: tbelaleg@yahoo.com.
[Ti] Título:Validated spectrophotometric and chromatographic methods for simultaneous determination of ketorolac tromethamine and phenylephrine hydrochloride.
[So] Source:Ann Pharm Fr;74(4):267-82, 2016 Jul.
[Is] ISSN:0003-4509
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:This work describes five simple and reliable spectrophotometric and chromatographic methods for analysis of the binary mixture of ketorolac tromethamine (KTR) and phenylephrine hydrochloride (PHE). Method I is based on the use of conventional Amax and derivative spectrophotometry with the zero-crossing technique where KTR was determined using its Amax and (1)D amplitudes at 323 and 341nm respectively, while PHE was determined by measuring the (1)D amplitudes at 248.5nm. Method II involves the application of the ratio spectra derivative spectrophotometry. For KTR, 12µg/mL PHE was used as a divisor and the (1)DD amplitudes at 265nm were plotted against KTR concentrations; while - by using 4µg/mL KTR as divisor - the (1)DD amplitudes at 243.5nm were found proportional to PHE concentrations. Method III depends on ratio-difference measurement where the peak to trough amplitudes between 260 and 284nm were measured and correlated to KTR concentration. Similarly, the peak to trough amplitudes between 235 and 260nm in the PHE ratio spectra were recorded. For method IV, the two compounds were separated using Merck HPTLC sheets of silica gel 60 F254 and a mobile phase composed of chloroform/methanol/ammonia (70:30:2, by volume) followed by densitometric measurement of KTR and PHE spots at 320 and 278nm respectively. Method V depends on HPLC-DAD. Effective chromatographic separation was achieved using Zorbax eclipse plus C8 column (4.6×250mm, 5µm) with a mobile phase consisting of 0.05M o-phosphoric acid and acetonitrile (50:50, by volume) at a flow rate 1mL/min and detection at 313 and 274nm for KTR and PHE respectively. Analytical performance of the developed methods was statistically validated according to the ICH guidelines with respect to linearity, ranges, precision, accuracy, detection and quantification limits. The validated spectrophotometric and chromatographic methods were successfully applied to the simultaneous analysis of KTR and PHE in synthetic mixtures of different proportions and laboratory-made ophthalmic solution.
[Mh] Termos MeSH primário: Cetorolaco de Trometamina/análise
Fenilefrina/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada
Limite de Detecção
Padrões de Referência
Reprodutibilidade dos Testes
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1WS297W6MV (Phenylephrine); 4EVE5946BQ (Ketorolac Tromethamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160221
[St] Status:MEDLINE


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[PMID]:26847918
[Au] Autor:El Yazbi FA; Hassan EM; Khamis EF; Ragab MA; Hamdy MM
[Ad] Endereço:Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria 21521, Egypt felyazbi@yahoo.com.
[Ti] Título:Development and Validation of a High-Performance Thin-Layer Chromatographic Method for the Simultaneous Determination of Two Binary Mixtures Containing Ketorolac Tromethamine with Phenylephrine Hydrochloride and with Febuxostat.
[So] Source:J Chromatogr Sci;54(5):819-28, 2016 May-Jun.
[Is] ISSN:1945-239X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A validated and highly selective high-performance thin-layer chromatography (HPTLC) method was developed for the determination of ketorolac tromethamine (KTC) with phenylephrine hydrochloride (PHE) (Mixture 1) and with febuxostat (FBX) (Mixture 2) in bulk drug and in combined dosage forms. The proposed method was based on HPTLC separation of the drugs followed by densitometric measurements of their spots at 273 and 320 nm for Mixtures 1 and 2, respectively. The separation was carried out on Merck HPTLC aluminum sheets of silica gel 60 F254 using chloroform-methanol-ammonia (7:3:0.1, v/v) and (7.5:2.5:0.1, v/v) as mobile phase for KTC/PHE and KTC/FBX mixtures, respectively. Linear regression lines were obtained over the concentration ranges 0.20-0.60 and 0.60-1.95 µg band(-1)for KTC and PHE (Mixture 1), respectively, and 0.10-1.00 and 0.25-2.50 µg band(-1) for KTC and FBX (Mixture 2), respectively, with correlation coefficients higher than 0.999. The method was successfully applied to the analysis of the two drugs in their synthetic mixtures and in their dosage forms. The mean percentage recoveries were in the range of 98-102%, and the RSD did not exceed 2%. The method was validated according to ICH guidelines and showed good performances in terms of linearity, sensitivity, precision, accuracy and stability.
[Mh] Termos MeSH primário: Cromatografia em Camada Delgada/métodos
Febuxostat/análise
Cetorolaco de Trometamina/análise
Fenilefrina/análise
[Mh] Termos MeSH secundário: Misturas Complexas
Formas de Dosagem
Limite de Detecção
Padrões de Referência
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Complex Mixtures); 0 (Dosage Forms); 101V0R1N2E (Febuxostat); 1WS297W6MV (Phenylephrine); 4EVE5946BQ (Ketorolac Tromethamine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160206
[St] Status:MEDLINE
[do] DOI:10.1093/chromsci/bmv250


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[PMID]:26782787
[Au] Autor:Pollack CV; Diercks DB; Thomas SH; Shapiro NI; Fanikos J; Mace SE; Rafique Z; Todd KH
[Ad] Endereço:Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA.
[Ti] Título:Patient-reported Outcomes from A National, Prospective, Observational Study of Emergency Department Acute Pain Management With an Intranasal Nonsteroidal Anti-inflammatory Drug, Opioids, or Both.
[So] Source:Acad Emerg Med;23(3):331-41, 2016 Mar.
[Is] ISSN:1553-2712
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Patient compliance and satisfaction with analgesics prescribed after emergency department (ED) care for acute pain are poorly understood, largely because of the lack of direct patient follow-up with the ED provider. Our objective was to compare patient satisfaction with three analgesia regimens prescribed for post-ED care-a nasally administered nonsteroidal anti-inflammatory drug (NSAID), an opioid, or combination therapy-by collecting granular follow-up on analgesic use, pain scores, side effects, work activity levels, and overall satisfaction directly from patients. METHODS: We designed a prospective registry linking ED assessment and analgesic management for acute pain of specific musculoskeletal or visceral etiologies with self-reported automated telephonic follow-up daily for the 4 days post-ED discharge. Patients were prescribed a specific NSAID (SPRIX, ketorolac tromethamine for nasal instillation) only, an oral opioid only, or both with the opioid clearly defined as rescue therapy, at the ED provider's discretion. RESULTS: There were 824 evaluable subjects. Maximum pain scores improved day to day more effectively with a ketorolac-based approach. Self-reported rates of return to work and work effectiveness were higher with SPRIX than with opioids or combination therapy. Adverse effects of nausea, constipation, drowsiness, and abdominal pain were higher each day among patients taking an opioid; nasal irritation was more common with SPRIX. Overall satisfaction at the end of the follow-up period was higher with SPRIX-based treatment than with opioid monotherapy. CONCLUSIONS: Automated telephonic follow-up of ED patients prescribed short-term analgesia is feasible. Ketorolac-based analgesia after an ED visit for many acute pain syndromes was associated with favorable patient outcomes and higher satisfaction than opioid-based therapy. SPRIX, an NSAID that is not available over the counter and has a novel delivery approach, may be useful for short-term post-ED outpatient analgesia.
[Mh] Termos MeSH primário: Analgésicos Opioides/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Serviço Hospitalar de Emergência/estatística & dados numéricos
Dor/tratamento farmacológico
Satisfação do Paciente
[Mh] Termos MeSH secundário: Administração Intranasal
Adulto
Analgésicos Opioides/administração & dosagem
Analgésicos Opioides/efeitos adversos
Anti-Inflamatórios não Esteroides/administração & dosagem
Anti-Inflamatórios não Esteroides/efeitos adversos
Quimioterapia Combinada
Uso de Medicamentos
Feminino
Seres Humanos
Cetorolaco de Trometamina
Masculino
Adesão à Medicação
Meia-Idade
Manejo da Dor
Medição da Dor
Avaliação de Resultados da Assistência ao Paciente
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Anti-Inflammatory Agents, Non-Steroidal); 4EVE5946BQ (Ketorolac Tromethamine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160120
[St] Status:MEDLINE
[do] DOI:10.1111/acem.12902



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