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[PMID]:27151143
[Au] Autor:Bunsupa S; Yamazaki M; Saito K
[Ad] Endereço:Department of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
[Ti] Título:Lysine-derived Alkaloids: Overview and Update on Biosynthesis and Medicinal Applications with Emphasis on Quinolizidine Alkaloids.
[So] Source:Mini Rev Med Chem;17(12):1002-1012, 2017.
[Is] ISSN:1875-5607
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plants produce a vast variety of specialized metabolites which can be a rich source for lead compounds for the development of new drugs. Alkaloids are one the largest groups of plant specialized metabolites important for natural product based pharmaceuticals. Of these, lysine (Lys)-derived alkaloids exhibit a wide range of pharmacological properties which are beneficial for humans. For instance they have anticancer, anti-Alzheimer's disease, anti-inflammatory, hypocholesterolemic and antiarrhtymic effects. Lys-derived alkaloids are widely distributed throughout the plant kingdom: they can be found in various species from clubmosses to flowering plants. Lys is one of the most essential amino acids for humans and livestock and is synthesized in the plastids of land plants. Lys-derived alkaloids can be divided into four major groups including quinolizidine, lycopodium, piperidine, and indolizidine alkaloids. Despite the importance of these compounds, the biosynthetic pathways of Lys-derived alkaloids are not well understood. With the exception of indolizidine alkaloids, Lys decarboxylase (LDC) is the enzyme involved in the first committed step of the biosynthesis by catalyzing the transformation of L-Lys into cadaverine. Cadaverine is then oxidized by copper amine oxidase (CuAO) and spontaneously cyclized to Δ1-piperideine Schiff base which is a universal intermediate for the production of various Lys-derived alkaloids. CONCLUSION: In this review, we briefly summarize the recent understanding about the structures, occurrences, analytical procedures, biosyntheses, and potential health effects and medical applications of Lys-derived alkaloids with emphasis on quinolizidine alkaloids (QAs).
[Mh] Termos MeSH primário: Alcaloides/biossíntese
Lisina/química
Quinolizidinas/química
[Mh] Termos MeSH secundário: Alcaloides/química
Indolizidinas/química
Lycopodium/química
Lycopodium/metabolismo
Piperidinas/química
Plantas/química
Plantas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Indolizidines); 0 (Piperidines); 0 (Quinolizidines); 67I85E138Y (piperidine); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.2174/1389557516666160506151213


  2 / 107 MEDLINE  
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[PMID]:27791349
[Au] Autor:Peng H; Wei E; Wang J; Zhang Y; Cheng L; Ma H; Deng Z; Qu X
[Ad] Endereço:Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuhan 430071, China.
[Ti] Título:Deciphering Piperidine Formation in Polyketide-Derived Indolizidines Reveals a Thioester Reduction, Transamination, and Unusual Imine Reduction Process.
[So] Source:ACS Chem Biol;11(12):3278-3283, 2016 12 16.
[Is] ISSN:1554-8937
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Piperidine and indolizidine are two basic units of alkaloids that are frequently observed in natural and synthetic compounds. Their biosynthesis in natural products is highly conserved and mostly derived from the incorporation of lysine cyclization products. Through in vitro reconstitution, we herein identified a novel pathway involving a group of polyketide-derived indolizidines, which comprises the processes of tandem two-electron thioester reduction, transamination, and imine reduction to convert acyl carrier protein (ACP)-tethered polyketide chains into the piperidine moieties of their indolizidine scaffolds. The enzymes that catalyze the imine reduction are distinct from previous known imine reductases, which have a fold of acyl-CoA dehydrogenase but do not require flavin for reduction. Our results not only provide a new way for the biosynthesis of the basic units of alkaloids but also show a novel class of imine reductases that may benefit the fields of biocatalysis and biomanufacturing.
[Mh] Termos MeSH primário: Indolizidinas/metabolismo
Piperidinas/metabolismo
Policetídeos/metabolismo
Streptomyces/enzimologia
[Mh] Termos MeSH secundário: Proteína de Transporte de Acila/metabolismo
Acil-CoA Desidrogenases/metabolismo
Vias Biossintéticas
Iminas/química
Iminas/metabolismo
Indolizidinas/química
Piperidinas/química
Policetídeos/química
Streptomyces/metabolismo
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acyl Carrier Protein); 0 (Imines); 0 (Indolizidines); 0 (Piperidines); 0 (Polyketides); 67I85E138Y (piperidine); EC 1.3.- (Acyl-CoA Dehydrogenases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE


  3 / 107 MEDLINE  
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[PMID]:27495899
[Au] Autor:Chen J; Lv H; Hu J; Ji M; Xue N; Li C; Ma S; Zhou Q; Lin B; Li Y; Yu S; Chen X
[Ad] Endereço:State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
[Ti] Título:CAT3, a novel agent for medulloblastoma and glioblastoma treatment, inhibits tumor growth by disrupting the Hedgehog signaling pathway.
[So] Source:Cancer Lett;381(2):391-403, 2016 10 28.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Medulloblastoma (MB) and glioblastoma (GBM) are the most prevalent malignant brain tumors. The identification of novel therapeutic strategies is urgent for MB and GBM patients. Herein, we discovered 13a-(S)-3-Hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine (PF403) strongly exhibited inhibitory activity against Hedgehog (Hh) pathway-hyperactivated MB and GBM cells with a 50% inhibitory concentration (IC50) of 0.01 nM. CAT3 was designed and synthesized as the prodrug of PF403 and displayed significant in vivo efficacy against MB and GBM. Mechanistic study revealed that CAT3 inhibited MB and GBM primarily by interrupting the Hh signaling pathway. At the molecular level, PF403 inhibited the cell surface accumulation of the Smoothened (Smo) receptor by directly binding or enhancing the interaction of Smo with the repressor Ptch1. Furthermore, PF403 significantly repressed Gli1 nuclear accumulation and transcription by promoting Sufu-Gli1 and PKA-Gli1 interactions. Collectively, our studies support the hypothesis that CAT3 is a promising therapeutic agent for the treatment of Hh-driven MB and GBM.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Proliferação Celular/efeitos dos fármacos
Neoplasias Cerebelares/tratamento farmacológico
Glioblastoma/tratamento farmacológico
Proteínas Hedgehog/metabolismo
Indolizidinas/farmacologia
Meduloblastoma/tratamento farmacológico
Fenantrenos/farmacologia
Pró-Fármacos/farmacologia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Antineoplásicos/administração & dosagem
Antineoplásicos/síntese química
Antineoplásicos/farmacocinética
Linhagem Celular Tumoral
Neoplasias Cerebelares/genética
Neoplasias Cerebelares/metabolismo
Neoplasias Cerebelares/patologia
Proteínas Quinases Dependentes de AMP Cíclico/metabolismo
Relação Dose-Resposta a Droga
Desenho de Drogas
Feminino
Glioblastoma/genética
Glioblastoma/metabolismo
Glioblastoma/patologia
Indolizidinas/administração & dosagem
Indolizidinas/síntese química
Indolizidinas/farmacocinética
Concentração Inibidora 50
Masculino
Meduloblastoma/genética
Meduloblastoma/metabolismo
Meduloblastoma/patologia
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos ICR
Camundongos Nus
Receptor Patched-1/genética
Receptor Patched-1/metabolismo
Fenantrenos/administração & dosagem
Fenantrenos/síntese química
Fenantrenos/farmacocinética
Pró-Fármacos/administração & dosagem
Pró-Fármacos/síntese química
Pró-Fármacos/farmacocinética
Proteínas Repressoras/genética
Proteínas Repressoras/metabolismo
Receptor Smoothened/genética
Receptor Smoothened/metabolismo
Carga Tumoral/efeitos dos fármacos
Ensaios Antitumorais Modelo de Xenoenxerto
Proteína GLI1 em Dedos de Zinco/genética
Proteína GLI1 em Dedos de Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (3-O-desmethyl-13a-deoxytylophorinine); 0 (3-pivaloyloxyl-6,7-dimethoxyphenanthro(9,10-b)indolizidine); 0 (Antineoplastic Agents); 0 (GLI1 protein, human); 0 (Hedgehog Proteins); 0 (Indolizidines); 0 (PTCH protein, human); 0 (Patched-1 Receptor); 0 (Phenanthrenes); 0 (Prodrugs); 0 (Repressor Proteins); 0 (SMO protein, human); 0 (SUFU protein, human); 0 (Smoothened Receptor); 0 (Zinc Finger Protein GLI1); EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171029
[Lr] Data última revisão:
171029
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160807
[St] Status:MEDLINE


  4 / 107 MEDLINE  
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[PMID]:26934056
[Au] Autor:Kalaitzakis D; Triantafyllakis M; Sofiadis M; Noutsias D; Vassilikogiannakis G
[Ad] Endereço:Department of Chemistry, University of Crete, Vasilika Vouton, 71003, Iraklion, Crete, Greece.
[Ti] Título:Photooxygenation of Furylalkylamines: Easy Access to Pyrrolizidine and Indolizidine Scaffolds.
[So] Source:Angew Chem Int Ed Engl;55(14):4605-9, 2016 Mar 24.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A highly adaptable method targeting the ubiquitous and very important pyrrolizidine and indolizidine scaffolds is presented. The general synthetic utility of the method is underscored by its application to the rapid and easy synthesis of five natural products starting from readily accessible alkylfuran precursors. These unprotected primary furylalkylamines are subjected to photooxygenation conditions, which initiate a complex cascade reaction sequence concluding with the production of high value motifs. This sequence can be tailored to need by varying the choice of both photosensitizer and base additive.
[Mh] Termos MeSH primário: Aminas/química
Indolizidinas/química
Oxigênio/química
Processos Fotoquímicos
Alcaloides de Pirrolizidina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amines); 0 (Indolizidines); 0 (Pyrrolizidine Alkaloids); S88TT14065 (Oxygen)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160303
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201600988


  5 / 107 MEDLINE  
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[PMID]:26777309
[Au] Autor:Michael JP
[Ad] Endereço:Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Johannesburg, Gauteng, South Africa. Electronic address: joseph.michael@wits.ac.za.
[Ti] Título:Simple Indolizidine and Quinolizidine Alkaloids.
[So] Source:Alkaloids Chem Biol;75:1-498, 2016.
[Is] ISSN:1099-4831
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This review of simple indolizidine and quinolizidine alkaloids (i.e., those in which the parent bicyclic systems are in general not embedded in polycyclic arrays) is an update of the previous coverage in Volume 55 of this series (2001). The present survey covers the literature from mid-1999 to the end of 2013; and in addition to aspects of the isolation, characterization, and biological activity of the alkaloids, much emphasis is placed on their total synthesis. A brief introduction to the topic is followed by an overview of relevant alkaloids from fungal and microbial sources, among them slaframine, cyclizidine, Steptomyces metabolites, and the pantocins. The important iminosugar alkaloids lentiginosine, steviamine, swainsonine, castanospermine, and related hydroxyindolizidines are dealt with in the subsequent section. The fourth and fifth sections cover metabolites from terrestrial plants. Pertinent plant alkaloids bearing alkyl, functionalized alkyl or alkenyl substituents include dendroprimine, anibamine, simple alkaloids belonging to the genera Prosopis, Elaeocarpus, Lycopodium, and Poranthera, and bicyclic alkaloids of the lupin family. Plant alkaloids bearing aryl or heteroaryl substituents include ipalbidine and analogs, secophenanthroindolizidine and secophenanthroquinolizidine alkaloids (among them septicine, julandine, and analogs), ficuseptine, lasubines, and other simple quinolizidines of the Lythraceae, the simple furyl-substituted Nuphar alkaloids, and a mixed quinolizidine-quinazoline alkaloid. The penultimate section of the review deals with the sizable group of simple indolizidine and quinolizidine alkaloids isolated from, or detected in, ants, mites, and terrestrial amphibians, and includes an overview of the "dietary hypothesis" for the origin of the amphibian metabolites. The final section surveys relevant alkaloids from marine sources, and includes clathryimines and analogs, stellettamides, the clavepictines and pictamine, and bis(quinolizidine) alkaloids.
[Mh] Termos MeSH primário: Alcaloides/química
Indolizidinas/química
Quinolizidinas/química
[Mh] Termos MeSH secundário: Animais
Biologia Marinha
Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Indolizidines); 0 (Quinolizidines)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160118
[Lr] Data última revisão:
160118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE


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[PMID]:26758492
[Au] Autor:Nakashima T; Miyano R; Iwatsuki M; Shirahata T; Kimura T; Asami Y; Kobayashi Y; Shiomi K; Petersson GA; Takahashi Y; Omura S
[Ad] Endereço:Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
[Ti] Título:Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601.
[So] Source:J Antibiot (Tokyo);69(8):611-5, 2016 Aug.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A new natural product, designated iminimycin A, was isolated from the cultured broth of a streptomycin-producing microbial strain, Streptomyces griseus OS-3601, via a physicochemical screening method using HP-20, silica gel and ODS column chromatographies and subsequent preparative HPLC. Iminimycin A is an indolizidine alkaloid, containing of an unusual iminium group and a cyclopropane ring with a triene side chain. The absolute configuration of iminimycin A was elucidated by NMR studies and electronic circular dichroism analysis. Iminimycin A shows anti-bacterial activity against Bacillus subtilis, Kocuria rhizophila and Xanthomonas campestris pv. orizae, and cytotoxic activity against HeLa S3 and Jurkat cells with IC50 values of 43 and 36 µM, respectively.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antineoplásicos/farmacologia
Streptomyces griseus/metabolismo
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Antibacterianos/química
Antibacterianos/isolamento & purificação
Antineoplásicos/química
Antineoplásicos/isolamento & purificação
Bacillus subtilis/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão/métodos
Dicroísmo Circular
Células HeLa
Seres Humanos
Indolizidinas/química
Indolizidinas/isolamento & purificação
Indolizidinas/farmacologia
Concentração Inibidora 50
Células Jurkat
Espectroscopia de Ressonância Magnética
Micrococcaceae/efeitos dos fármacos
Xanthomonas campestris/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents); 0 (Indolizidines); 0 (iminimycin A)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160114
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2015.142


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[PMID]:26710212
[Au] Autor:Hu Y; Zhang C; Zhao X; Wang Y; Feng D; Zhang M; Xie H
[Ad] Endereço:Research Department of Pharmacognosy, China Pharmacaeutical University , Nanjing, 211198, People's Republic of China.
[Ti] Título:(±)-Homocrepidine A, a Pair of Anti-inflammatory Enantiomeric Octahydroindolizine Alkaloid Dimers from Dendrobium crepidatum.
[So] Source:J Nat Prod;79(1):252-6, 2016 Jan 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A pair of racemic indolizidine enantiomers, (±)-homocrepidine A (1), and a piperidine derivative, homocrepidine B (2), were isolated from Dendrobium crepidatum along with the known alkaloid crepidine (3). The racemic mixture of 1 was separated into a pair of enantiomers, (+)-1 and (-)-1, by HPLC using a chiral chromatographic substrate, which represents the first successful example of resolving indolizidine racemic mixtures. The absolute configurations of (+)-1 and (-)-1 were assigned from single-crystal X-ray diffraction data. The evaluation of anti-inflammatory activity with LPS-induced RAW 264.7 macrophages revealed that (+)-1 strongly inhibited the production of nitric oxide (IC50, 3.6 µM) and significantly decreased the expression of inducible nitric oxide synthase, while (-)-1 and (±)-1 only had moderate inhibitory effects (IC50, 22.8 and 14.7 µM). Compound 2 showed moderate anti-inflammatory activity (IC50, 27.6 µM).
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Anti-Inflamatórios não Esteroides/isolamento & purificação
Anti-Inflamatórios não Esteroides/farmacologia
Dendrobium/química
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Indolizidinas/isolamento & purificação
Indolizidinas/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Animais
Anti-Inflamatórios não Esteroides/química
Cristalografia por Raios X
Medicamentos de Ervas Chinesas/isolamento & purificação
Indolizidinas/química
Concentração Inibidora 50
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Camundongos
Conformação Molecular
Estrutura Molecular
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico/biossíntese
Piperidinas
Caules de Planta/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Drugs, Chinese Herbal); 0 (Indolizidines); 0 (Lipopolysaccharides); 0 (Piperidines); 0 (homocrepidine A); 0 (homocrepidine B); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160122
[Lr] Data última revisão:
160122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151229
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b00801


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[PMID]:26212217
[Au] Autor:Kumari G; Singh RK
[Ad] Endereço:Nucleic Acids and Antiviral Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, India.
[Ti] Título:Molecular Modeling, Synthesis, and Anti-HIV Activity of Novel Isoindolinedione Analogues as Potent Non-nucleoside Reverse Transcriptase Inhibitors.
[So] Source:Chem Biol Drug Des;87(2):200-12, 2016 Feb.
[Is] ISSN:1747-0285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Different isoindolinedione derivatives bearing imine, amide, thioamide, and sulfonamide linkages have been designed in silico using discovery studio software (BIOVIA, San Diego, CA, USA), synthesized, and evaluated for their anti-HIV activity. SAR studies revealed that the linkages in these molecules did affect their anti-HIV activity and the molecules having sulfonamide linkages were the most potent HIV-RT inhibitors as the S=O bonds of the sulfonamide moiety interacted with Lys103 (NH or carbonyl or both) and Pro236; the NH part of the sulfonamide linkage formed bond with carbonyl of Lys101. blood-brain barrier (BBB) plots were also studied, and it was found that all the designed molecules have potential to cross BBB, a very vital criteria for anti-HIV drugs. In vitro screening was performed using HIV-1 strain IIIB in MT-4 cells using the MTT assay, and it was seen that some of these molecules were effective inhibitors of HIV-1 replication at nanomolar concentration with selectivity indices ranging from 33.75 to 73.33 under in vitro conditions. Some of these molecules have shown good anti-HIV activity at 3-4 nm concentrations. These derivatives have potential to be developed as lead molecules effective against HIV-1. Novel isoindolinedione derivatives as probable NNRTIs have been synthesized and characterized. Some of these molecules have shown good anti-HIV activity at 3-4 nm concentrations.
[Mh] Termos MeSH primário: Transcriptase Reversa do HIV/antagonistas & inibidores
HIV-1/enzimologia
Indolizidinas/química
Simulação de Acoplamento Molecular
Inibidores da Transcriptase Reversa/síntese química
[Mh] Termos MeSH secundário: Sítios de Ligação
Barreira Hematoencefálica/metabolismo
Linhagem Celular
Transcriptase Reversa do HIV/metabolismo
Seres Humanos
Indolizidinas/síntese química
Indolizidinas/metabolismo
Estrutura Terciária de Proteína
Inibidores da Transcriptase Reversa/química
Inibidores da Transcriptase Reversa/metabolismo
Relação Estrutura-Atividade
Sulfonamidas/química
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Indolizidines); 0 (Reverse Transcriptase Inhibitors); 0 (Sulfonamides); EC 2.7.7.49 (HIV Reverse Transcriptase)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150728
[St] Status:MEDLINE
[do] DOI:10.1111/cbdd.12620


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[PMID]:26690479
[Au] Autor:Diaz GJ
[Ad] Endereço:Laboratorio de Toxicología, Facultad de Medicina Veterinaria y de Zootecnia, Universidad Nacional de Colombia, Bogotá, Colombia. gjdiazg@unal.edu.co.
[Ti] Título:Toxicosis by Plant Alkaloids in Humans and Animals in Colombia.
[So] Source:Toxins (Basel);7(12):5408-16, 2015 Dec 11.
[Is] ISSN:2072-6651
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Due to its tropical location, chains of mountains, inter-Andean valleys, Amazon basin area, eastern plains and shores on both the Atlantic and Pacific Oceans, Colombia has many ecosystems and the second largest plant biodiversity in the world. Many plant species, both native and naturalized, are currently recognized as toxic for both animals and humans, and some of them are known to cause their toxic effects due to their alkaloid content. Among these, there are plants containing the hepatotoxic pyrrolizidine alkaloids, neurotoxins such as the indolizidine alkaloid swainsonine and the piperidine alkaloids coniine and γ-coniceine and tropane alkaloids. Unfortunately, the research in toxic plants in Colombia is not nearly proportional to its plant biodiversity and the scientific information available is only very scarce. The present review aims at summarizing the scarce information about plant alkaloid toxicosis in animals and humans in Colombia.
[Mh] Termos MeSH primário: Alcaloides/toxicidade
Plantas Tóxicas/toxicidade
[Mh] Termos MeSH secundário: Animais
Colômbia
Seres Humanos
Indolizidinas/toxicidade
Piperidinas/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Indolizidines); 0 (Piperidines)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151231
[Lr] Data última revisão:
151231
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE
[do] DOI:10.3390/toxins7124892


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[PMID]:26473429
[Au] Autor:Huang W; Kim SJ; Liu J; Zhang W
[Ad] Endereço:Department of Chemical and Biomolecular Engineering, University of California , Berkeley, California 94720, United States.
[Ti] Título:Identification of the Polyketide Biosynthetic Machinery for the Indolizidine Alkaloid Cyclizidine.
[So] Source:Org Lett;17(21):5344-7, 2015 Nov 06.
[Is] ISSN:1523-7052
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The cyclizidine biosynthetic gene cluster was identified from Streptomyces NCIB 11649, which revealed the polyketide biosynthetic machinery for cyclizidine alkaloid biosynthesis. Both in vivo mutagenesis study and in vitro biochemical analysis provided insight into the timing and mechanism of the biosynthetic enzymes that produce cyclizidine-type indolizidine alkaloids.
[Mh] Termos MeSH primário: Alcaloides/química
Indolizidinas/química
Policetídeos/metabolismo
[Mh] Termos MeSH secundário: Descoberta de Drogas
Estrutura Molecular
Família Multigênica
Streptomyces/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Indolizidines); 0 (Polyketides); 0 (ent-cyclizidine)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151017
[St] Status:MEDLINE
[do] DOI:10.1021/acs.orglett.5b02707



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