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[PMID]: 28748404 [Au] Autor: Scariot FJ; Jahn L; Delamare APL; Echeverrigaray S [Ad] Endereço: Institute of Biotechnology, University of Caxias do Sul, Caxias do Sul, Rio Grande Do Sul, Brazil. [Ti] Título: Necrotic and apoptotic cell death induced by Captan on Saccharomyces cerevisiae. [So] Source: World J Microbiol Biotechnol;33(8):159, 2017 Aug. [Is] ISSN: 1573-0972 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Captan is one of the most widely used broad-spectrum fungicide applied to control several early and late diseases of grapes, apples, and other fruits and vegetables, and as other phthalimide fungicides is defined as a multisite compound with thiol-reactivity. Captan can affect non-target organisms as yeasts, modifying microbial populations and fermentation processes. In this study, we asked whether Captan thiol-reactivity and other mechanisms are involved in acute Captan-induced cell death on aerobic growing Saccharomyces cerevisiae. Thus for, we analyze cellular protein and non-protein thiols, cell membrane integrity, reactive oxygen species accumulation, phosphatidylserine externalization, and apoptotic mutants behavior. The results showed that when submitted to acute Captan treatment most cells lost their membrane integrity and died by necrosis due to Captan reaction with thiols. However, part of the cells, even maintaining their membrane integrity, lost their culture ability. These cells showed an apoptotic behavior that may be the result of non-protein thiol depletion and consequent increase of reactive oxygen species (ROS). ROS accumulation triggers a metacaspase-dependent apoptotic cascade, as shown by the higher viability of the yca1-deleted mutant. Together, necrosis and apoptosis are responsible for the high mortality detected after acute Captan treatment of aerobically growing cells of S. cerevisiae. [Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos Captana/farmacologia Morte Celular/efeitos dos fármacos Saccharomyces cerevisiae/efeitos dos fármacos [Mh] Termos MeSH secundário: Membrana Celular/efeitos dos fármacos Fermentação Fungicidas Industriais/farmacologia Viabilidade Microbiana/efeitos dos fármacos Mutação Necrose Espécies Reativas de Oxigênio/metabolismo Saccharomyces cerevisiae/genética Saccharomyces cerevisiae/crescimento & desenvolvimento Proteínas de Saccharomyces cerevisiae/genética Proteínas de Saccharomyces cerevisiae/metabolismo Compostos de Sulfidrila/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Fungicides, Industrial); 0 (Reactive Oxygen Species); 0 (Saccharomyces cerevisiae Proteins); 0 (Sulfhydryl Compounds); EOL5G26Q9F (Captan) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170728 [St] Status: MEDLINE [do] DOI: 10.1007/s11274-017-2325-3

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[PMID]: 28646436 [Au] Autor: Podbielska M; Szpyrka E; Piechowicz B; Zwolak A; Sadlo S [Ad] Endereço: Department of Ecotoxicology, Institute of Applied Biotechnology, University of Rzeszów, Pigonia 1, 35-310, Rzeszów, Poland. magdapodbiel@gmail.com. [Ti] Título: Behavior of fluopyram and tebuconazole and some selected pesticides in ripe apples and consumer exposure assessment in the applied crop protection framework. [So] Source: Environ Monit Assess;189(7):350, 2017 Jul. [Is] ISSN: 1573-2959 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The supervised field trials were conducted in a commercial apple orchard in 2016. The trials were an attempt to determine a model for dissipation and toxicological evaluation of fluopyram, tebuconazole, captan, tetrahydrophthalimide (THPI), pirimicarb, spirodiclofen, and boscalid residues detected in fruit of Red Jonaprince, Lobo, and Gala varieties immediately before harvest. The analysis also covered amounts of pesticides still present in remnants of calyx in Lobo and Gala varieties immediately before harvest. Laboratory samples of ripe apples were collected within 14 days of the treatment. Levels of pesticide residues detected in the samples changed at a constant exponential rate, and the residue levels found in ripe apples of Red Jonaprince, Gala, and Lobo varieties immediately before harvest were below maximum residue levels (MRL). Overall, captan residues in remnants of calyx were at a level of 22.3% for the Gala variety and 9.3% for the Lobo variety. Likewise, the long-term daily intake of the detected substances by a Polish adult consumer was low, ranging from 0.02% ADI for pirimicarb to 0.72% ADI for captan. [Mh] Termos MeSH primário: Benzamidas/análise Contaminação de Alimentos/estatística & dados numéricos Malus/química Resíduos de Praguicidas/análise Piridinas/análise Triazóis/análise [Mh] Termos MeSH secundário: Captana Proteção de Cultivos/métodos Monitoramento Ambiental Contaminação de Alimentos/análise Frutas/química Seres Humanos Praguicidas/análise Ftalimidas Polônia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Benzamides); 0 (Pesticide Residues); 0 (Pesticides); 0 (Phthalimides); 0 (Pyridines); 0 (Triazoles); 27813-21-4 (tetrahydrophthalimide); 401ATW8TRW (tebuconazole); EOL5G26Q9F (Captan); F0VT7K5302 (N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170914 [Lr] Data última revisão: 170914 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170625 [St] Status: MEDLINE [do] DOI: 10.1007/s10661-017-6057-5

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[PMID]: 27196962 [Au] Autor: Lafleur B; Sauvé S; Duy SV; Labrecque M [Ad] Endereço: a Institut de recherche en biologie végétale, Université de Montréal , Montréal , QC , Canada. [Ti] Título: Phytoremediation of groundwater contaminated with pesticides using short-rotation willow crops: A case study of an apple orchard. [So] Source: Int J Phytoremediation;18(11):1128-35, 2016 Nov. [Is] ISSN: 1549-7879 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The occurrence of pesticides in groundwater represents an important health issue, notably for population whose drinking water supply source is located in agricultural areas. However, few solutions have been considered with regard to this issue. We tested the efficacy of a vegetal filtering system made of shrub willows planted at a high density (16,000 plants ha(-1)) to filter or degrade pesticides found in the groundwater flowing out of an apple orchard. Ethylene urea (EU), ethylene thiourea (ETU), tetrahydrophthalimide (THPI), atrazine, and desethylatrazine were monitored in the soil solution in willow and control plots over one growing season. ETU and atrazine concentrations were lower in the willow plots relative to the control plots, whereas desethylatrazine concentration was higher in the willow plots. No significant difference was detected for EU and THPI. Furthermore, pesticide concentrations displayed complex temporal patterns. These results suggest that willow filter systems can filter or degrade pesticides, notably ETU and atrazine, and could be used for phytoremediation purposes. Yet, this potential remains to be quantified with further studies using experimental settings allowing more estimation in time and space. [Mh] Termos MeSH primário: Fungicidas Industriais/metabolismo Água Subterrânea/análise Salix/metabolismo Poluentes do Solo/metabolismo Poluentes Químicos da Água/metabolismo [Mh] Termos MeSH secundário: Biodegradação Ambiental Captana/metabolismo Produtos Agrícolas/crescimento & desenvolvimento Água Potável/análise Malus/crescimento & desenvolvimento Maneb/metabolismo Quebeque Zineb/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Drinking Water); 0 (Fungicides, Industrial); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical); 12427-38-2 (Maneb); EOL5G26Q9F (Captan); R0HY55EB9E (mancozeb); X1FSB1OZPT (Zineb) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170406 [Lr] Data última revisão: 170406 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160520 [St] Status: MEDLINE [do] DOI: 10.1080/15226514.2016.1186593

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[PMID]: 26611369 [Au] Autor: Nesakumar N; Ramachandra BL; Sethuraman S; Krishnan UM; Rayappan JB [Ad] Endereço: Nanosensors Lab, SASTRA University, Thanjavur, Tamil Nadu, 613 401, India. [Ti] Título: Evaluation of Inhibition Efficiency for the Detection of Captan, 2,3,7,8-Tetrachlorodibenzodioxin, Pentachlorophenol and Carbosulfan in Water: An Electrochemical Approach. [So] Source: Bull Environ Contam Toxicol;96(2):217-23, 2016 Feb. [Is] ISSN: 1432-0800 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. The inhibition curves of captan, carbosulfan, TCDD and PCP were similar to Michaelis-Menten curve. TCDD held the minimum inhibitor Michaelis-Menten constant ([Formula: see text]) value (10.2 nM) in comparison with PCP (10.9 nM), carbosulfan (14.5 nM) and captan (7.9 × 10(3) nM). The maximum inhibition of AChE enzyme by captan was about 100 %, which was much higher than that of TCDD (72.7 %), PCP (68.1 %) and carbosulfan (47.7 %). The calculated theoretical sensitivity was in the order of TCDD > PCP > carbosulfan > captan. Comparing with TCDD (35.3 %), PCP (47.8 %) and carbosulfan (20.9 %), only the inhibition efficiency of captan (55.0 %) was the maximum. The developed bioelectrode exhibited high recovery and low relative standard deviation in local tap water samples. [Mh] Termos MeSH primário: Técnicas Biossensoriais Captana/análise Carbamatos/análise Pentaclorofenol/análise Resíduos de Praguicidas/análise Dibenzodioxinas Policloradas/análise Água/química [Mh] Termos MeSH secundário: Acetilcolinesterase/química Captana/química Carbamatos/química Pentaclorofenol/química Dibenzodioxinas Policloradas/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Carbamates); 0 (Pesticide Residues); 0 (Polychlorinated Dibenzodioxins); 059QF0KO0R (Water); D9BSU0SE4T (Pentachlorophenol); EC 3.1.1.7 (Acetylcholinesterase); EOL5G26Q9F (Captan); V1DGN4AK6G (carbosulfan) [Em] Mês de entrada: 1610 [Cu] Atualização por classe: 170103 [Lr] Data última revisão: 170103 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151128 [St] Status: MEDLINE [do] DOI: 10.1007/s00128-015-1705-3

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[PMID]: 26374656 [Au] Autor: Galea KS; MacCalman L; Jones K; Cocker J; Teedon P; Cherrie JW; van Tongeren M [Ad] Endereço: Centre for Human Exposure Science, Institute of Occupational Medicine (IOM), Edinburgh, UK. [Ti] Título: Urinary biomarker concentrations of captan, chlormequat, chlorpyrifos and cypermethrin in UK adults and children living near agricultural land. [So] Source: J Expo Sci Environ Epidemiol;25(6):623-31, 2015 Nov-Dec. [Is] ISSN: 1559-064X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: There is limited information on the exposure to pesticides experienced by UK residents living near agricultural land. This study aimed to investigate their pesticide exposure in relation to spray events. Farmers treating crops with captan, chlormequat, chlorpyrifos or cypermethrin provided spray event information. Adults and children residing ≤100 m from sprayed fields provided first-morning void urine samples during and outwith the spray season. Selected samples (1-2 days after a spray event and at other times (background samples)) were analysed and creatinine adjusted. Generalised Linear Mixed Models were used to investigate if urinary biomarkers of these pesticides were elevated after spray events. The final data set for statistical analysis contained 1518 urine samples from 140 participants, consisting of 523 spray event and 995 background samples which were analysed for pesticide urinary biomarkers. For captan and cypermethrin, the proportion of values below the limit of detection was greater than 80%, with no difference between spray event and background samples. For chlormequat and chlorpyrifos, the geometric mean urinary biomarker concentrations following spray events were 15.4 µg/g creatinine and 2.5 µg/g creatinine, respectively, compared with 16.5 µg/g creatinine and 3.0 µg/g creatinine for background samples within the spraying season. Outwith the spraying season, concentrations for chlorpyrifos were the same as those within spraying season backgrounds, but for chlormequat, lower concentrations were observed outwith the spraying season (12.3 µg/g creatinine). Overall, we observed no evidence indicative of additional urinary pesticide biomarker excretion as a result of spray events, suggesting that sources other than local spraying are responsible for the relatively low urinary pesticide biomarkers detected in the study population. [Mh] Termos MeSH primário: Agricultura/estatística & dados numéricos Captana/urina Clormequat/urina Clorpirifos/urina Exposição Ambiental/análise Praguicidas/urina Piretrinas/urina [Mh] Termos MeSH secundário: Adolescente Adulto Fatores Etários Idoso Idoso de 80 Anos ou mais Biomarcadores/urina Criança Pré-Escolar Feminino Seres Humanos Masculino Meia-Idade Inquéritos e Questionários Reino Unido/epidemiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Biomarkers); 0 (Pesticides); 0 (Pyrethrins); 1TR49121NP (cypermethrin); 8SUZ1123XX (Chlormequat); EOL5G26Q9F (Captan); JCS58I644W (Chlorpyrifos) [Em] Mês de entrada: 1608 [Cu] Atualização por classe: 170220 [Lr] Data última revisão: 170220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150917 [St] Status: MEDLINE [do] DOI: 10.1038/jes.2015.54

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[PMID]: 25895947 [Au] Autor: Nesakumar N; Sethuraman S; Krishnan UM; Rayappan JB [Ad] Endereço: Nanosensors Lab, SASTRA University, Thanjavur, Tamil Nadu, 613 401, India. [Ti] Título: Cyclic voltammetric acetylcholinesterase biosensor for the detection of captan in apple samples with the aid of chemometrics. [So] Source: Anal Bioanal Chem;407(16):4863-8, 2015 Jun. [Is] ISSN: 1618-2650 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The presence of captan residues in apples shows high toxicity, which often causes eye and skin irritation, dermatitis, conjunctivitis, and vomiting in humans. In this context, an electrochemical biosensor based on acetylcholinesterase (AChE) immobilized on a ZnO nanorod interface has been proposed. In this work, Hill, dose-response, and first-, second-, and third-order polynomial regression models were successfully applied and the prediction ability of these models was tested with the use of current density obtained from the cyclic voltammograms of appropriate captan solutions. The Pt/ZnO/AChE bioelectrode showed a high sensitivity of 0.538 µA cm(-2) µM(-1) in the linear range from 0.05 to 25.0 µM with a limit of detection of 107 nM. The recovery results were observed between 98.4 and 102.4 % from the apple sample. This work provides a new promising tool for the detection of captan in apple samples. [Mh] Termos MeSH primário: Acetilcolinesterase/química Técnicas Biossensoriais Captana/análise [Mh] Termos MeSH secundário: Técnicas Eletroquímicas Limite de Detecção [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: EC 3.1.1.7 (Acetylcholinesterase); EOL5G26Q9F (Captan) [Em] Mês de entrada: 1602 [Cu] Atualização por classe: 160512 [Lr] Data última revisão: 160512 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150422 [St] Status: MEDLINE [do] DOI: 10.1007/s00216-015-8687-1

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[PMID]: 25682009 [Au] Autor: Park DS; Jeon HJ; Park ES; Bae IK; Kim YE; Lee SE [Ad] Endereço: School of Applied Biosciences, Kyungpook National University, Daegu 702-701, Republic of Korea. [Ti] Título: Highly selective biomarkers for pesticides developed in Eisenia fetida using SELDI-TOF MS. [So] Source: Environ Toxicol Pharmacol;39(2):635-42, 2015 Mar. [Is] ISSN: 1872-7077 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The repeated use of pesticides, and their subsequent residues, has contributed to severe adverse effects on the environment, including risks to human health. Therefore, it is important to assess the quality of the environment to ensure it remains free from pesticide residues. The six pesticides tested in this study showed high mortality on Eisenia fetida with LC50 values ranging from 7.7 to 37.9 g L(-1). The strongest lethal effect resulted from the organochlorine insecticide endosulfan (LC50=7.7 g L(-1)). Following exposure to the carbamate pesticides, acetylcholinesterase activity in E. fetida decreased dramatically in comparison to the control. Carboxylesterase activity was only lowered in E. fetida exposed to propoxur, when compared to the control. The remaining five pesticides had no significant effect on carboxylesterase activity in E. fetida. In order to discover pesticide-specific biomarkers with differentially expressed proteins after exposure to pesticides, protein patterns of pesticide-treated E. fetida were analyzed using SELDI-TOF MS with Q10 ProteinChips. Protein patterns were compared with their intensities at the same mass-to-charge ratios (m/z). All 42 peaks had intensities with associated p-values less than 0.089, and 40 of these peaks had associated p-values of 0.05. Using SELDI-TOF MS technology, selective biomarkers for the six pesticides tested were found in E. fetida; four proteins with 5425, 5697, 9523, and 9868 m/z were consistently observed in the earthworms following exposure to the carbamates. [Mh] Termos MeSH primário: Oligoquetos/efeitos dos fármacos Praguicidas/toxicidade [Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo Animais Biomarcadores/metabolismo Captana/toxicidade Carbaril/toxicidade Carbofurano/toxicidade Carboxilesterase/metabolismo Clorpirifos/toxicidade Endossulfano/toxicidade Oligoquetos/metabolismo Propoxur/toxicidade Análise Serial de Proteínas Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Biomarkers); 0 (Pesticides); BFH029TL73 (Propoxur); EC 3.1.1.1 (Carboxylesterase); EC 3.1.1.7 (Acetylcholinesterase); EOL5G26Q9F (Captan); JCS58I644W (Chlorpyrifos); OKA6A6ZD4K (Endosulfan); R890C8J3N1 (Carbaryl); SKF77S6Y67 (Carbofuran) [Em] Mês de entrada: 1601 [Cu] Atualização por classe: 150410 [Lr] Data última revisão: 150410 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150216 [St] Status: MEDLINE

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[PMID]: 23742211 [Au] Autor: Zentai A; Sali J; Szabó IJ; Szeitzné-Szabó M; Ambrus A; Vásárhelyi A [Ad] Endereço: National Food Chain Safety Office, Directorate for Food Safety Risk Assessment, Budapest, Hungary. ZentaiA@nebih.gov.hu [Ti] Título: Factors affecting the estimated probabilistic acute dietary exposure to captan from apple consumption. [So] Source: Food Addit Contam Part A Chem Anal Control Expo Risk Assess;30(5):833-42, 2013. [Is] ISSN: 1944-0057 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The effect of the number of pesticide residue values below the LOQ/LOD of analytical methods, the variability of residues in individual fruits, mass of fruit units and the number of bootstrap iterations was studied on the probabilistically estimated acute exposure of consumers. The 4720 daily apple consumption data and the results of 1239 apple sample analyses for captan residues, performed within the Hungarian monitoring programme between 2005 and 2011, were used in this study as model matrix. Up to about 95th percentile exposure (µg/(kg bw·day)), simply multiplying each residue in composite samples with each consumption value gave similar estimates to those obtained with the complex procedure taking also into account the mass of and residues in individual fruits. However, the exposure above the 95th percentile calculated with the complex procedure gradually increased with increasing percentile level compared to the simple procedure. Including the high number of non-detects reduced the estimated exposure, which was the highest when only the residues measured in treated fruits were taken into account. The number of bootstrap iterations between 100 and 10,000 did not significantly affect the calculated exposure. The 99.99th percentile exposure amounted to 17.9% of the acute reference dose of 300 µg/(kg bw·day) for women of childbearing age. [Mh] Termos MeSH primário: Captana/administração & dosagem Dieta Exposição Ambiental Fungicidas Industriais/administração & dosagem Malus Probabilidade [Mh] Termos MeSH secundário: Seres Humanos Hungria Limite de Detecção [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Fungicides, Industrial); EOL5G26Q9F (Captan) [Em] Mês de entrada: 1401 [Cu] Atualização por classe: 130617 [Lr] Data última revisão: 130617 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130608 [St] Status: MEDLINE [do] DOI: 10.1080/19440049.2013.794977

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[PMID]: 23710563 [Au] Autor: Sadlo S; Duda M; Piechowicz B; Jazwa A [Ad] Endereço: Institute of Applied Biotechnology and Basic Sciences, University of Rzeszów, Kolbuszowa, Poland. s.sadlo@poczta.onet.pl [Ti] Título: Comparative study on disappearance trends of captan and trifloxystrobin residues on fruit and apple tree leaves using internal normalisation method. [So] Source: Food Addit Contam Part A Chem Anal Control Expo Risk Assess;30(5):826-32, 2013. [Is] ISSN: 1944-0057 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Supervised field trials were carried out in a commercial orchard in 2011. The purpose of the study was to assess the usefulness of the comparative method to examine the mechanism of disappearance of pesticide residues. Captan and trifloxystrobin residues were determined with the use of gas chromatograph equipped with a micro-electron capture detector. Disappearance trends of captan and trifloxystrobin residues in fruit and leaves were estimated using the method of internal normalisation, and based on that, the courses of concentration changes of these substances on fruit and leaves and the amount of these substances in one apple were established. The initial deposits of trifloxystrobin on leaves and fruits dropped by 50% within 8 and 4 days after treatment, respectively, in both varieties, whereas captan residues dropped by 50% within 29 days in leaves and 7 days in apples of the Olive Yellow varieties. [Mh] Termos MeSH primário: Acetatos/análise Anti-Infecciosos/análise Captana/análise Frutas/química Fungicidas Industriais/análise Iminas/análise Folhas de Planta/química [Mh] Termos MeSH secundário: Cromatografia Gasosa Metacrilatos/análise Estrobilurinas [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Acetates); 0 (Anti-Infective Agents); 0 (Fungicides, Industrial); 0 (Imines); 0 (Methacrylates); 0 (Strobilurins); EOL5G26Q9F (Captan); F625Z36B2D (trifloxystrobin) [Em] Mês de entrada: 1401 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130529 [St] Status: MEDLINE [do] DOI: 10.1080/19440049.2013.790088

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[PMID]: 23692481 [Au] Autor: Gottzein AK; Musshoff F; Madea B [Ad] Endereço: Institute of Legal Medicine, University of Bonn, Stiftsplatz 12, 53111, Bonn, Germany. A.Gottzein@gmx.de [Ti] Título: Systematic toxicological analysis revealing a rare case of captan ingestion. [So] Source: J Forensic Sci;58(4):1099-103, 2013 Jul. [Is] ISSN: 1556-4029 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: This article presents a case of suicide by intoxication with various pharmaceuticals, particularly anticonvulsants, combined with the fungicide captan. A cause of death could not be ascertained at autopsy. However, systematic toxicological analysis (STA) including a screening via solid-phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS) for (semi) volatile organic compounds revealed results suggesting a possible cause of death. The effects of captan on the human organism, its metabolism, and distribution will be discussed. Macroscopically, the cause of death was unascertained. STA revealed clonazepam, citalopram, and its metabolites, lamotrigine, levetiracetam, lacosamide, clonazepam, captan, and its metabolite tetrahydrophthalimide (THPI). For the first time, it was detected in human viscera. A quantification of THPI was performed to obtain distribution in the organs. The significance of a complete STA must be emphasized. The presence of THPI would have been missed without previous detection of captan. Consequently, this fatality would not have been investigated satisfactorily. [Mh] Termos MeSH primário: Captana/envenenamento Fungicidas Industriais/envenenamento [Mh] Termos MeSH secundário: Adulto Bile/química Química Encefálica Captana/análise Feminino Toxicologia Forense Cromatografia Gasosa-Espectrometria de Massas Conteúdo Gastrointestinal/química Seres Humanos Rim/química Fígado/química Ftalimidas/análise Microextração em Fase Sólida [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Fungicides, Industrial); 0 (Phthalimides); 27813-21-4 (tetrahydrophthalimide); EOL5G26Q9F (Captan) [Em] Mês de entrada: 1403 [Cu] Atualização por classe: 130710 [Lr] Data última revisão: 130710 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130523 [St] Status: MEDLINE [do] DOI: 10.1111/1556-4029.12154

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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