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[PMID]:28120069
[Au] Autor:Quinones-Hinojosa A; Raza SM; Ahmed I; Rincon-Torroella J; Chaichana K; Olivi A
[Ad] Endereço:Neurosurgical Oncology Outcomes Laboratory, Department of Neurosurgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. aquinon2@jhmi.edu.
[Ti] Título:Middle Temporal Gyrus Versus Inferior Temporal Gyrus Transcortical Approaches to High-Grade Astrocytomas in the Mediobasal Temporal Lobe: A Comparison of Outcomes, Functional Restoration, and Surgical Considerations.
[So] Source:Acta Neurochir Suppl;124:159-164, 2017.
[Is] ISSN:0065-1419
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: High-grade astrocytomas of the mesial temporal lobe may pose surgical challenges. Several approaches (trans-sylvian, subtemporal, and transcortical) have been designed to circumnavigate the critical neurovascular structures and white fiber tracts that surround this area. Considering the paucity of literature on the transcortical approach for these lesions, we describe our institutional experience with transcortical approaches to Grade III/IV astrocytomas in the mesial temporal lobe. METHODS: Between 1999 and 2009, 23 patients underwent surgery at the Johns Hopkins Medical Institutions for Grade III/IV astrocytomas involving the mesial temporal lobe (without involvement of the temporal neocortex). Clinical notes, operative records, and imaging were reviewed. RESULTS: Thirteen patients had tumors in the dominant hemisphere. All patients underwent surgery via a transcortical approach (14 via the inferior temporal gyrus and 9 via the middle temporal gyrus). Gross total resection was obtained in 92 % of the cohort. Neurological outcomes were: clinically significant stroke (2 patients), new visual deficits (2 patients), new speech deficit (1 patient); seizure control (53 %). CONCLUSIONS: In comparison to reported results in the literature for the transylvian and subtemporal approaches, the transcortical approach may provide the access necessary for a gross total resection with minimal neurological consequences. In our series of patients, there was no statistically significant difference in outcomes between the middle temporal gyrus versus the inferior temporal gyrus trajectories.
[Mh] Termos MeSH primário: Astrocitoma/cirurgia
Neoplasias Encefálicas/cirurgia
Procedimentos Neurocirúrgicos/métodos
Lobo Temporal/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Astrocitoma/complicações
Astrocitoma/patologia
Neoplasias Encefálicas/complicações
Neoplasias Encefálicas/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Gradação de Tumores
Complicações Pós-Operatórias/epidemiologia
Estudos Retrospectivos
Convulsões/etiologia
Distúrbios da Fala/epidemiologia
Acidente Vascular Cerebral/epidemiologia
Tretoquinol
Carga Tumoral
Transtornos da Visão/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
JIO3275WGI (Tretoquinol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1007/978-3-319-39546-3_25


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[PMID]:27565104
[Au] Autor:Rahnama-Moghadam S; Brown ME; Meffert JJ
[Ad] Endereço:University of Texas Health Science Center at San Antonio, TX, USA. Email: rahnamamogha@uthscsa.edu.
[Ti] Título:Vesicular eruption in a 2-year-old boy.
[So] Source:J Fam Pract;65(7):E1-3, 2016 Jul.
[Is] ISSN:1533-7294
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A bath with scented soap prompted a flare of the boy's eczema. Days later, he was hospitalized with diffuse erosions covering 90% of his body. What was the cause?
[Mh] Termos MeSH primário: Aciclovir/uso terapêutico
Antivirais/uso terapêutico
Exantema/tratamento farmacológico
Exantema/virologia
Erupção Variceliforme de Kaposi/diagnóstico
Erupção Variceliforme de Kaposi/tratamento farmacológico
Simplexvirus/isolamento & purificação
[Mh] Termos MeSH secundário: Antibacterianos
Pré-Escolar
Eczema/induzido quimicamente
Seres Humanos
Masculino
Mentha/efeitos adversos
Perfumes/efeitos adversos
Sabões/efeitos adversos
Esteroides/uso terapêutico
Tacrolimo/uso terapêutico
Tretoquinol
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antiviral Agents); 0 (Perfume); 0 (Soaps); 0 (Steroids); JIO3275WGI (Tretoquinol); WM0HAQ4WNM (Tacrolimus); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160828
[St] Status:MEDLINE


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[PMID]:24832624
[Au] Autor:Contu VR; Kotake Y; Toyama T; Okuda K; Miyara M; Sakamoto S; Samizo S; Sanoh S; Kumagai Y; Ohta S
[Ad] Endereço:Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
[Ti] Título:Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.
[So] Source:J Neurochem;130(6):826-38, 2014 Sep.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Parkinson's disease (PD) is a common neurodegenerative disease, but its pathogenesis remains elusive. A mutation in ubiquitin C-terminal hydrolase L1 (UCH-L1) is responsible for a form of genetic PD which strongly resembles the idiopathic PD. We previously showed that 1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline (3',4'DHBnTIQ) is an endogenous parkinsonism-inducing dopamine derivative. Here, we investigated the interaction between 3',4'DHBnTIQ and UCH-L1 and its possible role in the pathogenesis of idiopathic PD. Our results indicate that 3',4'DHBnTIQ binds to UCH-L1 specifically at Cys152 in vitro. In addition, 3',4'DHBnTIQ treatment increased the amount of UCH-L1 in the insoluble fraction of SH-SY5Y cells and inhibited its hydrolase activity to 60%, reducing the level of ubiquitin in the soluble fraction of SH-SY5Y cells. Catechol-modified UCH-L1 as well as insoluble UCH-L1 were detected in the midbrain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated PD model mice. Structurally as well as functionally altered UCH-L1 have been detected in the brains of patients with idiopathic PD. We suggest that conjugation of UCH-L1 by neurotoxic endogenous compounds such as 3',4'DHBnTIQ might play a key role in onset and progression of idiopathic PD. We investigated the interaction between ubiquitin C-terminal hydrolase L1 (UCH-L1) and the brain endogenous parkinsonism inducer 1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline (3',4'DHBnTIQ). Our results indicate that 3',4'DHBnTIQ binds to UCH-L1 specifically at cysteine 152 and induces its aggregation. 3',4'DHBnTIQ also inhibits the hydrolase activity of UCH-L1. Catechol-modified as well as insoluble UCH-L1 were detected in the midbrains of MPTP-treated Parkinson's disease (PD) model mice. Conjugation of UCH-L1 by neurotoxic endogenous compounds like 3',4'DHBnTIQ might play a key role in onset and progression of PD.
[Mh] Termos MeSH primário: Dopamina/análogos & derivados
Dopamina/metabolismo
Neurotoxinas/metabolismo
Doença de Parkinson/metabolismo
Tretoquinol/análogos & derivados
Ubiquitina Tiolesterase/metabolismo
[Mh] Termos MeSH secundário: Animais
Western Blotting
Catecóis/química
Catecóis/farmacologia
Linhagem Celular Tumoral
Sobrevivência Celular
Eletroforese em Gel de Ágar
Escherichia coli/metabolismo
Seres Humanos
Indicadores e Reagentes
Mesencéfalo/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Modelos Moleculares
Ligação Proteica
Proteínas Recombinantes/química
Proteínas Recombinantes/isolamento & purificação
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Tretoquinol/metabolismo
Tretoquinol/farmacologia
Ubiquitina Tiolesterase/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline); 0 (Catechols); 0 (Indicators and Reagents); 0 (Neurotoxins); 0 (Recombinant Proteins); EC 3.1.2.15 (Ubiquitin carboxyl-Terminal Hydrolase L-1, human); EC 3.4.19.12 (Ubiquitin Thiolesterase); JIO3275WGI (Tretoquinol); LF3AJ089DQ (catechol); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140517
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.12762


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[PMID]:23560573
[Au] Autor:Whiting DM; Tomycz ND; Bailes J; de Jonge L; Lecoultre V; Wilent B; Alcindor D; Prostko ER; Cheng BC; Angle C; Cantella D; Whiting BB; Mizes JS; Finnis KW; Ravussin E; Oh MY
[Ad] Endereço:Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA.
[Ti] Título:Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.
[So] Source:J Neurosurg;119(1):56-63, 2013 Jul.
[Is] ISSN:1933-0693
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECT: Deep brain stimulation (DBS) of the lateral hypothalamic area (LHA) has been suggested as a potential treatment for intractable obesity. The authors present the 2-year safety results as well as early efficacy and metabolic effects in 3 patients undergoing bilateral LHA DBS in the first study of this approach in humans. METHODS: Three patients meeting strict criteria for intractable obesity, including failed bariatric surgery, underwent bilateral implantation of LHA DBS electrodes as part of an institutional review board- and FDA-approved pilot study. The primary focus of the study was safety; however, the authors also received approval to collect data on early efficacy including weight change and energy metabolism. RESULTS: No serious adverse effects, including detrimental psychological consequences, were observed with continuous LHA DBS after a mean follow-up of 35 months (range 30-39 months). Three-dimensional nonlinear transformation of postoperative imaging superimposed onto brain atlas anatomy was used to confirm and study DBS contact proximity to the LHA. No significant weight loss trends were seen when DBS was programmed using standard settings derived from movement disorder DBS surgery. However, promising weight loss trends have been observed when monopolar DBS stimulation has been applied via specific contacts found to increase the resting metabolic rate measured in a respiratory chamber. CONCLUSIONS: Deep brain stimulation of the LHA may be applied safely to humans with intractable obesity. Early evidence for some weight loss under metabolically optimized settings provides the first "proof of principle" for this novel antiobesity strategy. A larger follow-up study focused on efficacy along with a more rigorous metabolic analysis is planned to further explore the benefits and therapeutic mechanism behind this investigational therapy.
[Mh] Termos MeSH primário: Peso Corporal
Estimulação Encefálica Profunda/métodos
Metabolismo Energético
Região Hipotalâmica Lateral/cirurgia
Obesidade/cirurgia
Obesidade/terapia
[Mh] Termos MeSH secundário: Cirurgia Bariátrica
Imagem Corporal
Estimulação Encefálica Profunda/efeitos adversos
Comportamento Alimentar
Feminino
Seguimentos
Seres Humanos
Região Hipotalâmica Lateral/fisiologia
Masculino
Meia-Idade
Obesidade/metabolismo
Obesidade/psicologia
Projetos Piloto
Testes Psicológicos
Tretoquinol
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
JIO3275WGI (Tretoquinol)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:130409
[St] Status:MEDLINE
[do] DOI:10.3171/2013.2.JNS12903


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[PMID]:22686498
[Au] Autor:Kretschmer L; Pratsch AL
[Ad] Endereço:Department of Dermatology, Venereology and Allergology, University of Göttingen, Robert-Koch-Straße 3, Göttingen, Germany. lkre@med.uni-goettingen.de
[Ti] Título:Leg swelling after inguinal sentinel lymph node biopsy and primary melanoma excision with a safety margin.
[So] Source:J Dtsch Dermatol Ges;10(10):733-9, 2012 Oct.
[Is] ISSN:1610-0387
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Risk-factors for leg swelling following primary melanoma excision and inguinal sentinel lymphadenectomy (SLNE) have not been sufficiently investigated. PATIENTS AND METHODS: We prospectively studied three parameters in 105 subjects: 1) subjectively perceived swelling, 2) clinically diagnosed swelling and 3) photo-optical measurement of volume differences between both legs. RESULTS: Perceived swelling, clinically diagnosed swelling, and manifest edema occurred in 31%, 15%, and 7% of patients respectively. Following inguinal SLNE, there was a mean volume increase of 1.5% in the operated leg. Both the lower leg and the thigh increased in volume. Obesity, primary melanoma location on the lower leg, and inguinal seromas were identified as significant risk factors for postoperative swelling. Wider excision margins around a primary melanoma on the thigh were also associated with a significant increase in volume. Age, sex, the number of sentinel lymph nodes, the drainage fluid volume, and the time since SLNE were non-significant. CONCLUSIONS: Both inguinal SLNE and primary melanoma excision may contribute to minimal fluid accumulation in the leg. More than two-thirds of patients did not have any swelling. Obesity, location of the primary melanoma at a distal site on the leg, a wide safety margin, and seromas are associated with postoperative leg swelling.
[Mh] Termos MeSH primário: Edema/epidemiologia
Melanoma/epidemiologia
Melanoma/patologia
Complicações Pós-Operatórias/epidemiologia
Biópsia de Linfonodo Sentinela/estatística & dados numéricos
Neoplasias Cutâneas/epidemiologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Comorbidade
Feminino
Alemanha/epidemiologia
Seres Humanos
Canal Inguinal/patologia
Canal Inguinal/cirurgia
Perna (Membro)
Masculino
Melanoma/cirurgia
Meia-Idade
Prevalência
Fatores de Risco
Neoplasias Cutâneas/cirurgia
Tretoquinol
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
JIO3275WGI (Tretoquinol)
[Em] Mês de entrada:1305
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120613
[St] Status:MEDLINE
[do] DOI:10.1111/j.1610-0387.2012.07941.x


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[PMID]:22474754
[Au] Autor:Dainese L; Guarino A; Burba I; Esposito G; Pompilio G; Polvani G; Rossini A
[Ad] Endereço:Department of Cardiovascular Surgery, University of Milan, Centro Cardiologico Monzino IRCCS, Milan, Italy. luca.dainese@ccfm.it
[Ti] Título:Heart valve engineering: decellularized aortic homograft seeded with human cardiac stromal cells.
[So] Source:J Heart Valve Dis;21(1):125-34, 2012 Jan.
[Is] ISSN:0966-8519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIM OF THE STUDY: The adult human heart contains a cardiac mesenchymal stromal cell (CStC) population with residual cardiovascular plasticity. The study aim was to investigate the ability of CStCs to populate decellularized aortic homograft leaflets, without mechanical stimulation. METHODS: The ability of CStCs to acquire valve endothelial and interstitial cell phenotypes was tested using in vitro assays. First, trypsin-decellularized aortic leaflets were seeded with CStCs under static conditions; tissue section analyses were then performed before and after decellularization, and at 10, 20, and 30 days after reseeding. RESULTS: Following in vitro treatment, the CStCs differentiated along the endothelial lineage, as shown by their capacity to uptake acetylated low-density lipoprotein and to secrete the pro-angiogenic factor, vascular endothelial growth factor. After seeding, CStCs were able to adhere to the leaflet surface, rescuing up to the 90% of the original cell density and expressing the mature endothelial marker, von Willebrandt factor. The CStC supernatants were also positive for matrix metalloprotease-2 (MMP-2), which confirmed the ability of these cells to penetrate within the leaflet structure; this also suggested that CStCs, once engrafted, would contribute to the extracellular matrix turnover. Accordingly, although at a lower efficiency, CStC repopulation was also evident in the inner portions of the leaflet. CONCLUSION: Seeded CStCs were able to reconstitute, without mechanical stimulation, an endothelial-like layer and to partially infiltrate decellularized homograft leaflets. Hence, CStCs appear to be a potentially useful cell type for engineered heart valves.
[Mh] Termos MeSH primário: Valva Aórtica
Bioprótese
Sobrevivência de Enxerto/imunologia
Transplante de Células-Tronco Mesenquimais
Engenharia Tecidual
Transplante Homólogo/métodos
[Mh] Termos MeSH secundário: Adulto
Valva Aórtica/imunologia
Valva Aórtica/cirurgia
Diferenciação Celular
Células Endoteliais/transplante
Feminino
Próteses Valvulares Cardíacas
Implante de Prótese de Valva Cardíaca/instrumentação
Implante de Prótese de Valva Cardíaca/métodos
Seres Humanos
Masculino
Falha de Prótese
Engenharia Tecidual/instrumentação
Engenharia Tecidual/métodos
Transplantes
Tretoquinol
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
JIO3275WGI (Tretoquinol)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120406
[St] Status:MEDLINE


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[PMID]:22394355
[Au] Autor:Nelson MR; Lanza LA; Reeder CB; Scott RL; McCullough AE; Chandrasekaran K; Click RL
[Ad] Endereço:Division of Cardiovascular Diseases, Mayo Clinic Scottsdale, Arizona, USA.
[Ti] Título:Histologic remission of cardiac amyloidosis: a case report.
[So] Source:Amyloid;19(2):106-9, 2012 Jun.
[Is] ISSN:1744-2818
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The main determinant of survival in amyloid light chain amyloidosis is cardiac involvement. The rate of change in wall thickness may be a strong predictor of survival. After treatment, some hematologic responders have had documented regression of wall thickness by echocardiography with resolution of heart failure symptoms. Herein, we demonstrate a case of treated immunoglobulin light chain cardiac amyloidosis with echocardiographic wall thinning and cardiac biopsies demonstrating complete histologic remission. This observation suggests a mechanism of treatment response and that with appropriately timed treatment, cardiac deposition of amyloid fibrils can be completely reversed.
[Mh] Termos MeSH primário: Amiloidose/diagnóstico por imagem
Cardiomiopatias/diagnóstico por imagem
[Mh] Termos MeSH secundário: Amiloide/metabolismo
Amiloidose/tratamento farmacológico
Amiloidose/metabolismo
Cardiomiopatias/tratamento farmacológico
Cardiomiopatias/metabolismo
Seres Humanos
Masculino
Meia-Idade
Indução de Remissão
Tretoquinol
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid); 0 (amyloid L, human); JIO3275WGI (Tretoquinol)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120308
[St] Status:MEDLINE
[do] DOI:10.3109/13506129.2012.660892


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[PMID]:21785043
[Au] Autor:Comer BT; Young AB; Gal TJ
[Ad] Endereço:Division of Otolaryngology, Head & Neck Surgery, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536-0293, USA. btcome2@uky.edu
[Ti] Título:Impact of endoscopic surgical techniques on efficiency in pituitary surgery.
[So] Source:Otolaryngol Head Neck Surg;145(5):732-6, 2011 Nov.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess the impact of the introduction of endoscopic surgical techniques into a neurosurgical practice for pituitary surgery on operative efficiency. STUDY DESIGN: Case series with chart review. SETTING: Tertiary referral center. SUBJECTS AND METHODS: Patients undergoing transsphenoidal pituitary surgery over a 4-year period were identified. The approach over this period evolved from classic transseptal surgery to exclusively endoscopic techniques. Patients were classified as having transseptal surgery, endoscopic approach with microsurgical resection, aborted endoscopic resection with subsequent microsurgery, and exclusive endoscopic techniques. Patient and surgeon demographics, operative times, total operating room times, and room setup time were examined. Univariate analysis and multivariate regression modeling were used to assess outcome measures. RESULTS: One hundred seven patients were identified. The use of the endoscope for either sphenoid exposure alone (n = 41) or for the entire procedure (n = 35) resulted in a significant reduction in operative and room times compared to transseptal approaches (n = 25). Exclusively endoscopic techniques resulted in a significant reduction in operative and room times independent of all other clinical and surgical parameters (P < .001). Progressive use of endoscopic techniques resulted in statistically significant progressive reduction in setup time (P = .001), operative time (P = .04), and total room time (P = .03) over the study period. CONCLUSION: The transition from transseptal transsphenoidal pituitary surgery to endoscopic techniques implies a learning process for both neurosurgeon and otolaryngologist. Despite this, a noteworthy reduction in operative times, operating room times, and room setup times is observed. The impact of endoscopic techniques on efficiency in pituitary surgery is discussed.
[Mh] Termos MeSH primário: Endoscopia
Hipofisectomia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Eficiência
Feminino
Seres Humanos
Masculino
Microcirurgia
Meia-Idade
Fatores de Tempo
Tretoquinol
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
JIO3275WGI (Tretoquinol)
[Em] Mês de entrada:1112
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110726
[St] Status:MEDLINE
[do] DOI:10.1177/0194599811416753


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[PMID]:20848201
[Au] Autor:Richards D; Davis D; Yan P; Guha S
[Ad] Endereço:Department of Internal Medicine, Division of Gastroenterology, Hepatology, and Nutrition, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. David.Richards@uth.tmc.edu
[Ti] Título:Unusual case of small cell gastric carcinoma: case report and literature review.
[So] Source:Dig Dis Sci;56(4):951-7, 2011 Apr.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Small cell carcinomas are among the most aggressive, poorly differentiated, and highly malignant of the neuroendocrine tumors (NETs). Of which, small cell gastric carcinoma is a rare small cell neuroendocrine tumor. The purpose of our study was to present this case and perform a comprehensive literature review. METHODS AND RESULTS: We review a case of small cell gastric carcinoma that is particularly unusual in that it occurred in a woman from the US when the majority of cases of small cell gastric carcinoma have been reported in men from East Asia, and more specifically, from Japan. The diagnosis was made after endoscopy revealed a large ulcerated mass in the gastric cardia of Borrmann type 3. Biopsies revealed multiple small basophilic cells underlying the squamous epithelium of the esophagus and cardiac mucosa, indicating the presence of a tumor at the gastroesophageal junction. Immunostaining established the diagnosis with positive stains for chromogranin, synaptophysin, and CD56. Our patient is being treated with chemotherapy, but many different treatment regimens have been tried for small cell gastric carcinoma with variable success. CONCLUSIONS: Overall prognosis for small cell gastric carcinoma is dismal. Neuroendocrine tumors in general have variable clinical behaviors and prognosis is dependent on the neuroendocrine tumor type. The adoption of a standardized classification system for neuroendocrine tumors could improve the recognition of infrequently encountered neuroendocrine tumors like small cell gastric carcinoma and will enhance strategies for treatment and thus improve prognosis for patients with these rare and aggressive tumors.
[Mh] Termos MeSH primário: Carcinoma de Células Pequenas/diagnóstico
Neoplasias Gástricas/diagnóstico
[Mh] Termos MeSH secundário: Antígenos CD/análise
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Biópsia
Carboplatina/uso terapêutico
Carcinoma de Células Pequenas/tratamento farmacológico
Carcinoma de Células Pequenas/patologia
Cromograninas/análise
Diabetes Mellitus Tipo 2/tratamento farmacológico
Endoscopia
Etoposídeo/uso terapêutico
Feminino
Seres Humanos
Hipoglicemiantes/uso terapêutico
Masculino
Meia-Idade
Prognóstico
Neoplasias Gástricas/tratamento farmacológico
Neoplasias Gástricas/patologia
Sinaptofisina/análise
Tretoquinol
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Chromogranins); 0 (Hypoglycemic Agents); 0 (Synaptophysin); 6PLQ3CP4P3 (Etoposide); BG3F62OND5 (Carboplatin); JIO3275WGI (Tretoquinol)
[Em] Mês de entrada:1106
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:100918
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-010-1404-1


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[PMID]:20413057
[Au] Autor:Shaheen PE; Legrand SB; Walsh D; Estfan B; Davis MP; Lagman RL; Riaz M; Cheema B
[Ad] Endereço:The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA.
[Ti] Título:Errors in opioid prescribing: a prospective survey in cancer pain.
[So] Source:J Pain Symptom Manage;39(4):702-11, 2010 Apr.
[Is] ISSN:1873-6513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Cancer pain is debilitating and has multidimensional consequences. It can be treated adequately in up to 90% of patients by following pain management guidelines. Nevertheless, inadequate pain control remains a global problem. OBJECTIVES: We surveyed prescribing patterns in patients referred to our Palliative Medicine Program (PMP) to identify common errors in opioid use. METHODS: Consecutive cancer patients seen by our PMP were prospectively surveyed for the presence of pain and errors in opioid prescribing at the time of initial consultation. Our recommendations to correct and optimize pain management also were recorded. RESULTS: One hundred eighty-six consecutive cancer patients were screened. One hundred seventeen (63%) had cancer pain, 151 opioid prescribing errors were detected, and 147 different recommendations were made. Most common were failure to order around-the-clock opioids for constant pain, and the failure to treat or prevent opioid side effects. Multiple errors were more common in females, but the sex difference did not reach statistical significance. There was no difference in the errors by pain severity or reason for consultation. CONCLUSION: Opioid prescribing errors were common. Females may be at greater risk of multiple errors. A PM consultation program is effective in identifying and correcting a wide variety of opioid prescribing errors.
[Mh] Termos MeSH primário: Analgésicos Opioides/uso terapêutico
Erros de Medicação/estatística & dados numéricos
Neoplasias/tratamento farmacológico
Neoplasias/epidemiologia
Dor/epidemiologia
Dor/prevenção & controle
Prescrições/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Comorbidade
Feminino
Seres Humanos
Masculino
Meia-Idade
Ohio/epidemiologia
Prevalência
Estudos Prospectivos
Medição de Risco
Fatores de Risco
Tretoquinol
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); JIO3275WGI (Tretoquinol)
[Em] Mês de entrada:1007
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100424
[St] Status:MEDLINE
[do] DOI:10.1016/j.jpainsymman.2009.09.009



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