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[PMID]: | 28107600 |
[Au] Autor: | Pichler R; Fritz J; Heidegger I; Steiner E; Culig Z; Klocker H; Fuchs D |
[Ad] Endereço: | Urological Laboratory and Division of Experimental Urology, Department of Urology, Biocenter, Medical University Innsbruck, Innsbruck, Austria. |
[Ti] Título: | Predictive and prognostic role of serum neopterin and tryptophan breakdown in prostate cancer. |
[So] Source: | Cancer Sci;108(4):663-670, 2017 Apr. | [Is] ISSN: | 1349-7006 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | The γ-interferon-induced enzymes indoleamine 2,3-dioxygenase and GTP-cyclohydrolase are key players in tumor immune escape mechanisms. We quantified serum levels of neopterin and tryptophan breakdown (tryptophan, kynurenine, and kynurenine-to-tryptophan ratio) in addition to prostate-specific antigen (PSA) in newly diagnosed prostate cancer (PCa) patients (n = 100) before radical prostatectomy (RP) as well as at time of biochemical recurrence (BCR) after RP (n = 50) in comparison to healthy men (n = 49). Effects of biomarkers on the risk of PCa diagnosis on transrectal biopsy, worse histopathological characteristics of the RP specimens, and cancer-specific survival (CSS) after BCR were investigated. Neopterin (hazard ratio [HR], 2.46; 95% confidence interval [CI], 1.08-5.61; P = 0.032) and kynurenine (HR, 2.93; 95% CI, 1.26-6.79; P = 0.012) levels were univariately associated with CSS. When adjusted for other biomarkers, only neopterin remained an independent predictor of CSS (HR, 2.56; 95% CI, 1.07-6.12; P = 0.035). Only PSA was associated with an increased risk of PCa diagnosis on biopsy, univariately (odds ratio, 3.14; 95% CI, 1.68-5.88; P < 0.001) as well when adjusted for other biomarkers (odds ratio, 3.29; 95% CI, 1.70-6.35; P < 0.001). Moreover, only preoperative PSA was able to predict positive surgical margin (area under the receiver operating characteristic curve [AUC] = 0.71; 95% CI, 0.59-0.82; P = 0.001), higher Gleason score (AUC = 0.75; 95% CI, 0.66-0.85; P < 0.001) and extraprostatic involvement (AUC = 0.79; 95% CI, 0.69-0.88; P < 0.001) at RP specimens, respectively. Although serum neopterin and tryptophan breakdown cannot be considered as biomarkers in detecting PCa or in predicting worse final pathological findings, neopterin levels are useful for stratifying patients into different prognostic groups after BCR. |
[Mh] Termos MeSH primário: |
Cinurenina/sangue Neopterina/sangue Neoplasias da Próstata/sangue Triptofano/sangue
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[Mh] Termos MeSH secundário: |
Adulto Idoso Biomarcadores Tumorais/sangue Seres Humanos Estimativa de Kaplan-Meier Modelos Logísticos Masculino Meia-Idade Análise Multivariada Avaliação de Resultados (Cuidados de Saúde)/métodos Avaliação de Resultados (Cuidados de Saúde)/estatística & dados numéricos Período Pós-Operatório Valor Preditivo dos Testes Período Pré-Operatório Prognóstico Modelos de Riscos Proporcionais Antígeno Prostático Específico/sangue Prostatectomia Neoplasias da Próstata/diagnóstico Neoplasias da Próstata/cirurgia Curva ROC
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Biomarkers, Tumor); 343-65-7 (Kynurenine); 670-65-5 (Neopterin); 8DUH1N11BX (Tryptophan); EC 3.4.21.77 (Prostate-Specific Antigen) |
[Em] Mês de entrada: | 1709 |
[Cu] Atualização por classe: | 170926 |
[Lr] Data última revisão:
| 170926 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170121 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1111/cas.13171 |
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