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  1 / 13799 MEDLINE  
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[PMID]:28453010
[Au] Autor:Sethi S; Ooe M; Sakamoto T; Fujimoto K
[Ad] Endereço:School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan. kenzo@jaist.ac.jp.
[Ti] Título:Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside.
[So] Source:Mol Biosyst;13(6):1152-1156, 2017 Jun 01.
[Is] ISSN:1742-2051
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Photo-chemical deamination of cytosine using 3-cyanovinylcarbazole nucleoside ( K) mediated photo-cross-linking is a technique for site-directed mutagenesis. Using this technique in vivo requires the elimination of a high-temperature incubation step; instead, incubation should be carried out under physiological conditions. To improve the reactivity of K mediated photo-cross-link induced deamination of cytosine under physiological conditions, an evaluation of base pairing in cytosine was carried out with respect to its deamination. Guanine was replaced with 4 different counter bases (inosine, 2-aminopurine, 5-nitroindole, and nebularine), showing distinct hydrogen bonding patterns with target cytosine, which was incorporated at the -1 position with respect to K in the K-modified photo-responsive oligodeoxyribonucleotides to ascertain the role of hydrogen bonding in deamination under physiological conditions. Among the counter bases, inosine showed the highest acceleration towards the photo-induced deamination reaction.
[Mh] Termos MeSH primário: Citosina/química
DNA/química
Guanina/química
Nucleosídeos/química
[Mh] Termos MeSH secundário: 2-Aminopurina/química
Pareamento de Bases
Desaminação
Ligações de Hidrogênio
Indóis/química
Estrutura Molecular
Mutagênese Sítio-Dirigida
Oligodesoxirribonucleotídeos/química
Nucleosídeos de Purina/química
Ribonucleosídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoles); 0 (Nucleosides); 0 (Oligodeoxyribonucleotides); 0 (Purine Nucleosides); 0 (Ribonucleosides); 452-06-2 (2-Aminopurine); 5Z93L87A1R (Guanine); 8J337D1HZY (Cytosine); 9007-49-2 (DNA); B8B604PS4P (nebularine); O2BHX6EDBN (5-nitroindole)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1039/c7mb00082k


  2 / 13799 MEDLINE  
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[PMID]:29231931
[Au] Autor:Imani Nejad M; Yang D; Shen B; Gates KS
[Ad] Endereço:Department of Chemistry, University of Missouri, 125 Chemistry Bldg, Columbia, MO 65211, USA. gatesk@missouri.edu.
[Ti] Título:Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA.
[So] Source:Chem Commun (Camb);54(3):256-259, 2018 Jan 02.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:It may be useful to develop prodrugs that are selectively activated by oxidative stress in cancer cells to release cell-killing reactive intermediates. However, relatively few chemical strategies exist for the activation of prodrugs under conditions of oxidative stress. Here we provide evidence for a novel process in which oxidation of a thiol residue in the natural product leinamycin E1 by H O and other byproducts of cellular oxidative stress initiates generation of an episulfonium ion that selectively alkylates guanine residues in duplex DNA.
[Mh] Termos MeSH primário: Antineoplásicos Alquilantes/química
DNA/química
Guanina/química
Lactamas Macrocíclicas/química
Pró-Fármacos/química
[Mh] Termos MeSH secundário: Alquilação
Antineoplásicos Alquilantes/síntese química
Dano ao DNA
Compostos Férricos/química
Peróxido de Hidrogênio/química
Lactamas Macrocíclicas/síntese química
Oxirredução
Pró-Fármacos/síntese química
Xantina/química
Xantina Oxidase/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Alkylating); 0 (Ferric Compounds); 0 (Lactams, Macrocyclic); 0 (Prodrugs); 0 (leinamycin E1); 1AVZ07U9S7 (Xanthine); 5Z93L87A1R (Guanine); 9007-49-2 (DNA); BBX060AN9V (Hydrogen Peroxide); EC 1.17.3.2 (Xanthine Oxidase); LUX2X1H1IC (ammonium ferric sulfate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1039/c7cc08482j


  3 / 13799 MEDLINE  
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[PMID]:29274339
[Au] Autor:Alniss H; Zamiri B; Khalaj M; Pearson CE; Macgregor RB
[Ad] Endereço:College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.
[Ti] Título:Thermodynamic and spectroscopic investigations of TMPyP4 association with guanine- and cytosine-rich DNA and RNA repeats of C9orf72.
[So] Source:Biochem Biophys Res Commun;495(4):2410-2417, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: An expansion of the hexanucleotide repeat (GGGGCC)n·(GGCCCC)n in the C9orf72 promoter has been shown to be the cause of Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). The C9orf72 repeat can form four-stranded structures; the cationic porphyrin (TMPyP4) binds and distorts these structures. METHODS: Isothermal titration calorimetry (ITC), and circular dichroism (CD) were used to study the binding of TMPyP4 to the C-rich and G-rich DNA and RNA oligos containing the hexanucleotide repeat at pH 7.5 and 0.1 M K . RESULTS: The CD spectra of G-rich DNA and RNA TMPyP4 complexes showed features of antiparallel and parallel G-quadruplexes, respectively. The shoulder at 260 nm in the CD spectrum becomes more intense upon formation of complexes between TMPyP4 and the C-rich DNA. The peak at 290 nm becomes more intense in the c-rich RNA molecules, suggesting induction of an i-motif structure. The ITC data showed that TMPyP4 binds at two independent sites for all DNA and RNA molecules. CONCLUSIONS: For DNA, the data are consistent with TMPyP4 stacking on the terminal tetrads and intercalation. For RNA, the thermodynamics of the two binding modes are consistent with groove binding and intercalation. In both cases, intercalation is the weaker binding mode. These findings are considered with respect to the structural differences of the folded DNA and RNA molecules and the energetics of the processes that drive site-specific recognition by TMPyP4; these data will be helpful in efforts to optimize the specificity and affinity of the binding of porphyrin-like molecules.
[Mh] Termos MeSH primário: Proteína C9orf72/química
Proteína C9orf72/genética
Citosina/química
DNA/química
Guanina/química
RNA/química
Sequências Repetitivas de Ácido Nucleico
[Mh] Termos MeSH secundário: Composição de Bases
Sítios de Ligação
Calorimetria
Dicroísmo Circular
DNA/genética
Ligação Proteica
RNA/genética
Relação Estrutura-Atividade
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (C9orf72 Protein); 5Z93L87A1R (Guanine); 63231-63-0 (RNA); 8J337D1HZY (Cytosine); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


  4 / 13799 MEDLINE  
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[PMID]:28448876
[Au] Autor:Sebesta F; Burda JV
[Ad] Endereço:Department of Chemical Physics and Optics, Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, 121 16 Prague 2, Czech Republic.
[Ti] Título:Study on electronic properties, thermodynamic and kinetic parameters of the selected platinum(II) derivatives interacting with guanine.
[So] Source:J Inorg Biochem;172:100-109, 2017 Jul.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Interaction of hydrated forms of several potential anticancer agents (PtCl (diaminocyclohexane), trans-[PtCl (NH )(thiazole)], cis-[PtCl (NH )(piperidine)], and cis-PtCl (NH )(cyclohexylamine) complexes) with guanine are explored and compared with an analogous interaction of cisplatin. Basic electronic properties, binding and stabilization energies are determined and energy profiles for the aquation reaction are estimated at the B3LYP/6-311++G(2df,2pd) level of theory. It is found that the substitution reaction is an exothermic and exergonic process with ΔG slightly less negative than -20kcal/mol. The largest energy release occurs for PtCl(H O)(diaminocyclohexane) complex. The rate constants for the Pt(II) complexes in the chloro- and hydroxo-form are compared and an impact of the ligand in the trans position to water is discussed.
[Mh] Termos MeSH primário: Fenômenos Eletromagnéticos
Guanina/química
Platina/química
Termodinâmica
[Mh] Termos MeSH secundário: Antineoplásicos/química
Cinética
Compostos Organoplatínicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organoplatinum Compounds); 49DFR088MY (Platinum); 5Z93L87A1R (Guanine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


  5 / 13799 MEDLINE  
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[PMID]:29242886
[Au] Autor:Romero EE; Hernandez FE
[Ad] Endereço:Department of Chemistry, University of Central Florida, P. O. Box 162366, Orlando, Florida 32816-2366, USA. florencio.hernandez@ucf.edu.
[Ti] Título:Solvent effect on the intermolecular proton transfer of the Watson and Crick guanine-cytosine and adenine-thymine base pairs: a polarizable continuum model study.
[So] Source:Phys Chem Chem Phys;20(2):1198-1209, 2018 Jan 03.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Herein we present our results on the study of the double proton transfer (DPT) mechanism in the adenine-thymine (AT) and guanine-cytosine (GC) base pairs, both in gas phase and in solution. The latter was modeled using the polarizable continuum method (PCM) in different solvents. According to our DFT calculations, the DPT may occur for both complexes in a stepwise mechanism in condensate phase. In gas phase only the GC base pair exhibits a concerted DPT mechanism. Using the Wigner's tunneling corrections to the transition state theory we demonstrate that such corrections are important for the prediction of the rate constants of both systems in gas and in condensate phase. We also show that (i) as the polarity of the medium decreases the equilibrium constant of the DPT reaction increases in both complexes, and (ii) that the equilibrium constant in the GC complex is four orders of magnitude larger than in AT. This observation suggests that the spontaneous mutations in DNA base pairs are more probable in GC than in AT.
[Mh] Termos MeSH primário: Pareamento de Bases
DNA/química
Modelos Moleculares
[Mh] Termos MeSH secundário: Adenina
Citosina
Guanina
Prótons
Solventes
Timina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protons); 0 (Solvents); 5Z93L87A1R (Guanine); 8J337D1HZY (Cytosine); 9007-49-2 (DNA); JAC85A2161 (Adenine); QR26YLT7LT (Thymine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp05356h


  6 / 13799 MEDLINE  
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[PMID]:29237296
[Au] Autor:Mak LY; Seto WK; Lai CL; Yuen MF
[Ad] Endereço:a Department of Medicine , The University of Hong Kong, Queen Mary Hospital , Hong Kong , China.
[Ti] Título:Pharmacokinetic evaluation of besifovir for the treatment of HBV infection.
[So] Source:Expert Opin Drug Metab Toxicol;14(1):101-106, 2018 Jan.
[Is] ISSN:1744-7607
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Besifovir (LB80380) is a relatively new oral acyclic nucleotide phosphonate. We reviewed the pharmacokinetic characteristics of LB80380 and discussed its role in the treatment of chronic hepatitis B infection. Areas covered: LB80380 is a prodrug of LB80331 and LB80317. It is rapidly absorbed when taken orally. Escalating doses of besifovir produce linear increase of the plasma concentration. Doses above 60mg are effective for inhibiting HBV in human. Using 60mg as an example, the maximal concentration of LB80331 in plasma is 397 ng/mL. The time required to reach maximal concentration in plasma and elimination half-life are 2.0 and 3.0 h, respectively. Besifovir and its metabolites are mainly excreted via the kidneys. Its antiviral efficacy is non-inferior to ETV 0.5mg daily. It is generally safe in terms of renal and bone toxicity. The most common adverse event is carnitine depletion which affects almost all patients on besifovir requiring carnitine supplementation. Expert opinion: Besifovir demonstrated predictable pharmacokinetic characteristics in human subjects. Few clinical studies on besifovir have been conducted. More data are expected particularly for special populations. The adverse events upon long term exposure should be monitored. Large scale head-to-head trials comparing besifovir with existing NA, especially tenofovir alafenamide, should be conducted.
[Mh] Termos MeSH primário: Antivirais/administração & dosagem
Guanina/análogos & derivados
Hepatite B Crônica/tratamento farmacológico
Organofosfonatos/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Animais
Antivirais/efeitos adversos
Antivirais/farmacocinética
Relação Dose-Resposta a Droga
Guanina/administração & dosagem
Guanina/efeitos adversos
Guanina/farmacocinética
Meia-Vida
Seres Humanos
Organofosfonatos/efeitos adversos
Organofosfonatos/farmacocinética
Pró-Fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (((1-((2-amino-9H-purin-9-yl)methyl)cyclopropyl)oxy)methylphosphonic acid dipivoxyl); 0 (Antiviral Agents); 0 (Organophosphonates); 0 (Prodrugs); 5Z93L87A1R (Guanine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1080/17425255.2018.1417983


  7 / 13799 MEDLINE  
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[PMID]:29220796
[Au] Autor:Yan LH; Le Roux A; Boyapelly K; Lamontagne AM; Archambault MA; Picard-Jean F; Lalonde-Seguin D; St-Pierre E; Najmanovich RJ; Fortier LC; Lafontaine D; Marsault É
[Ad] Endereço:Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec, J1H 5N4, Canada; Department of Pharmacology-Physiology, Université de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec, J1H 5N4, Canada.
[Ti] Título:Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.
[So] Source:Eur J Med Chem;143:755-768, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Riboswitches recently emerged as possible targets for the development of alternative antimicrobial approaches. Guanine-sensing riboswitches in the bacterial pathogen Clostridioides difficile (formerly known as Clostridium difficile) constitute potential targets based on their involvement in the regulation of basal metabolic control of purine compounds. In this study, we deciphered the structure-activity relationship of several guanine derivatives on the guanine riboswitch and determined their antimicrobial activity. We describe the synthesis of purine analogs modified in ring B as well as positions 2 and 6. Their biological activity was determined by measuring their affinity for the C. difficile guanine riboswitch and their inhibitory effect on bacterial growth, including a counter-screen to discriminate against riboswitch-independent antibacterial effects. Altogether, our results suggest that improvements in riboswitch binding affinity in vitro do not necessarily translate into improved antibacterial activity in bacteria, despite the fact that some structure-activity relationship was observed at least with respect to binding affinity.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Clostridium difficile/efeitos dos fármacos
Guanina/antagonistas & inibidores
Purinas/farmacologia
Riboswitch/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/síntese química
Antibacterianos/química
Clostridium difficile/crescimento & desenvolvimento
Clostridium difficile/metabolismo
Relação Dose-Resposta a Droga
Guanina/metabolismo
Testes de Sensibilidade Microbiana
Estrutura Molecular
Purinas/síntese química
Purinas/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Purines); 0 (Riboswitch); 5Z93L87A1R (Guanine); W60KTZ3IZY (purine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


  8 / 13799 MEDLINE  
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[PMID]:28974474
[Au] Autor:Catarina Teodoro Castro B; Cançado de Faria R; Faria BF; Azevedo V; Lara Dos Santos L; Júnior MC; Machado CR; de Oliveira Lopes D
[Ad] Endereço:Laboratory of Molecular Biology, Federal University of São João Del-Rei (CCO), Av. Sebastião Gonçalves Coelho, 400, Divinópolis, MG 35501-296, Brazil. Electronic address: barbarateodoro@outlook.com.
[Ti] Título:UvrB protein of Corynebacterium pseudotuberculosis complements the phenotype of knockout Escherichia coli and recognizes DNA damage caused by UV radiation but not 8-oxoguanine in vitro.
[So] Source:Gene;639:34-43, 2018 Jan 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In prokaryotic cells, the UvrB protein plays a central role in nucleotide excision repair, which is involved in the recognition of bulky DNA lesions generated by chemical or physical agents. The present investigation aimed to characterize the uvrB gene of Corynebacterium pseudotuberculosis (CpuvrB) and evaluate its involvement in the DNA repair system of this pathogenic organism. In computational analysis, the alignment of the UvrB protein sequences of Escherichia coli, Mycobacterium tuberculosis, Bacillus caldotenax and Corynebacterium pseudotuberculosis showed high similarity and the catalytic amino acid residues and functional domains are preserved. A CpUvrB model was constructed by comparative modeling and presented structural similarity with the UvrB of E. coli. Moreover, in molecular docking analysis CpUvrB showed favorable interaction with EcUvrA and revealed a preserved ATP incorporation site. Heterologous functional complementation assays using E. coli uvrB-deficient cells exposed to UV irradiation showed that the CpUvrB protein contributed to an increased survival rate in relation to those in the absence of CpUvrB. Damaged oligonucleotides containing thymine dimer or 8-oxoguanine lesion were synthesized and incubated with CpUvrB protein, which was able to recognize and excise UV irradiation damage but not 8-oxoguanine. These results suggest that CpUvrB is involved in repairing lesions derived from UV light and encodes a protein orthologous to EcUvrB.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Corynebacterium pseudotuberculosis/genética
Dano ao DNA
Escherichia coli/genética
Guanina/análogos & derivados
Raios Ultravioleta
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Proteínas de Bactérias/metabolismo
Clonagem Molecular
Corynebacterium pseudotuberculosis/metabolismo
Corynebacterium pseudotuberculosis/efeitos da radiação
Técnicas de Silenciamento de Genes
Guanina/metabolismo
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 5614-64-2 (8-hydroxyguanine); 5Z93L87A1R (Guanine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE


  9 / 13799 MEDLINE  
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[PMID]:29095312
[Au] Autor:Kang FB; Wang L; Sun DX
[Ad] Endereço:aLiver Disease Diagnosis and Treatment Center, Bethune International Peace Hospital bOrthopedic Research Institute, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
[Ti] Título:Hepatitis B virus infection in an HBsAb-positive lymphoma patient who received chemotherapy: A case report.
[So] Source:Medicine (Baltimore);96(44):e8518, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Tumor chemotherapy could weaken the immune system of patients, which might enhance the body sensitivities to the exogenous pathogens, among which the hepatitis B virus (HBV) infection should be concerned because of the higher chances of infection and the severe outcomes, especially in East Asia. The titer level of hepatitis B surface antibody (HBsAb) higher than 10 IU/L is considered to offer immunocompetent individuals adequate protection. However, whether this level is enough to the tumor patients during chemotherapy remains unclear. PATIENT CONCERNS: A 58-year-old female lymphoma patient was admitted to our hospital for asthenia, nausea, vomiting, and abnormal liver function lasting over 1 week and diagnosed as acute hepatitis B. The patient just finished a course of chemotherapy with CHOP regimen and had recent record (78.61 IU/L) of HBsAb positive. The only risk of infection we could found was that the patient had received blood transfusion shortly after chemotherapy from a donor who was recovering from an asymptomatic acute HBV infection. INTERVENTION: The patient was administered with entecavir and glycyrrhizic acid agent, and then the disease was resolved successfully with hepatitis B surface antigen serological conversion. LESSONS: Tumor chemotherapy might have weakened the immune system of the patient and enhanced the body sensitivities to hepatitis B virus, then led to the infection. We concluded that HBsAb-positive status, at least "weakly positive," might not enough to provide protection for tumor patients on chemotherapy though this level was enough for health individuals and donors recuperating from subclinical acute hepatitis B might be another potential risk of HBV infection.
[Mh] Termos MeSH primário: Anticorpos Anti-Hepatite B/sangue
Antígenos de Superfície da Hepatite B/imunologia
Vírus da Hepatite B/imunologia
Hepatite B/imunologia
Linfoma/imunologia
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Antivirais/uso terapêutico
Ciclofosfamida/uso terapêutico
Doxorrubicina/uso terapêutico
Feminino
Guanina/análogos & derivados
Guanina/uso terapêutico
Hepatite B/etiologia
Hepatite B/virologia
Seres Humanos
Linfoma/tratamento farmacológico
Linfoma/virologia
Meia-Idade
Prednisolona/uso terapêutico
Reação Transfusional
Vincristina/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Hepatitis B Antibodies); 0 (Hepatitis B Surface Antigens); 5968Y6H45M (entecavir); 5J49Q6B70F (Vincristine); 5Z93L87A1R (Guanine); 80168379AG (Doxorubicin); 8N3DW7272P (Cyclophosphamide); 9PHQ9Y1OLM (Prednisolone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008518


  10 / 13799 MEDLINE  
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[PMID]:28941814
[Au] Autor:Basher MA; Rahman KM; Jackson PJM; Thurston DE; Fox KR
[Ad] Endereço:Biological Sciences, Life Sciences Building 85, University of Southampton, Southampton SO17 1BJ, UK.
[Ti] Título:Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA.
[So] Source:Biophys Chem;230:53-61, 2017 Nov.
[Is] ISSN:1873-4200
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:DNA footprinting and melting experiments have been used to examine the sequence-specific binding of C8-conjugates of pyrrolobenzodiazepines (PBDs) and benzofused rings including benzothiophene and benzofuran, which are attached using pyrrole- or imidazole-containing linkers. The conjugates modulate the covalent attachment points of the PBDs, so that they bind best to guanines flanked by A/T-rich sequences on either the 5'- or 3'-side. The linker affects the binding, and pyrrole produces larger changes than imidazole. Melting studies with 14-mer oligonucleotide duplexes confirm covalent attachment of the conjugates, which show a different selectivity to anthramycin and reveal that more than one ligand molecule can bind to each duplex.
[Mh] Termos MeSH primário: Benzodiazepinas/química
DNA/química
Pirróis/química
[Mh] Termos MeSH secundário: Antramicina/química
Antramicina/metabolismo
Sequência de Bases
Benzodiazepinas/metabolismo
Sítios de Ligação
DNA/metabolismo
Pegada de DNA
Desoxirribonuclease I/metabolismo
Guanina/química
Simulação de Dinâmica Molecular
Conformação de Ácido Nucleico
Desnaturação de Ácido Nucleico
Oligonucleotídeos/química
Oligonucleotídeos/metabolismo
Pirróis/metabolismo
Espectrometria de Fluorescência
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oligonucleotides); 0 (Pyrroles); 0 (pyrrolo(2,1-c)(1,4)benzodiazepine); 0WZD9Y66WN (Anthramycin); 12794-10-4 (Benzodiazepines); 5Z93L87A1R (Guanine); 9007-49-2 (DNA); EC 3.1.21.1 (Deoxyribonuclease I)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE



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