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[PMID]:28453848
[Au] Autor:Kakiuchi S; Tsuji M; Nishimura H; Yoshikawa T; Wang L; Takayama-Ito M; Kinoshita H; Lim CK; Fujii H; Yamada S; Harada S; Oka A; Mizuguchi M; Taniguchi S; Saijo M
[Ad] Endereço:Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
[Ti] Título:Association of the Emergence of Acyclovir-Resistant Herpes Simplex Virus Type 1 With Prognosis in Hematopoietic Stem Cell Transplantation Patients.
[So] Source:J Infect Dis;215(6):865-873, 2017 03 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Antiviral-resistant herpes simplex virus type 1 (HSV-1) has been recognized as an emerging clinical problem among patients undergoing hematopoietic stem cell transplantation (HSCT). Methods: A prospective observational study was conducted at a hematological center over a 2-year period. Oropharyngeal swab samples were serially collected each week from 1 week before and up to 100 days after HSCT and were tested for virus isolation. The HSV-1 isolates were tested for sensitivity to acyclovir (ACV). The prognosis of patients with ACV-resistant (ACVr) HSV-1 and the genetic background of the ACVr HSV-1 isolates were assessed. Results: Herpes simplex virus type 1 was isolated in 39 of 268 (15%) HSCT patients within 100 days after transplantation. Acyclovir-resistant HSV-1 emerged in 11 of these 39 patients (28%). The 100-day death rates of HSCT patients without HSV-1 shedding, those with only ACV-sensitive HSV-1 shedding, and those with ACVr HSV-1 shedding were 31%, 39%, and 64%, respectively. Patients with HSV-1, including ACVr HSV-1, shedding showed a significantly higher mortality rate. Relapsed malignancies were a significant risk factor for the emergence of ACVr HSV-1. Acyclovir resistance was attributable to viral thymidine kinase and DNA polymerase mutations in 6 and 5 patients, respectively. Conclusions: Herpes simplex virus type 1, including ACVr HSV-1, shedding was associated with poorer outcome in HSCT patients, even if HSV disease did not always occur. Patients with relapsed malignancies were at especially high risk for the emergence of ACVr HSV-1.
[Mh] Termos MeSH primário: Aciclovir/uso terapêutico
Antivirais/uso terapêutico
Farmacorresistência Viral
Transplante de Células-Tronco Hematopoéticas/mortalidade
Herpes Simples/tratamento farmacológico
Herpesvirus Humano 1/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
DNA Polimerase Dirigida por DNA/genética
Feminino
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Herpes Simples/virologia
Herpesvirus Humano 1/isolamento & purificação
Seres Humanos
Japão
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Análise Multivariada
Complicações Pós-Operatórias/virologia
Prognóstico
Modelos de Riscos Proporcionais
Estudos Prospectivos
Recidiva
Taxa de Sobrevida
Timidina Quinase/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Antiviral Agents); EC 2.7.1.21 (Thymidine Kinase); EC 2.7.7.7 (DNA-Directed DNA Polymerase); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix042


  2 / 8309 MEDLINE  
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[PMID]:29402251
[Au] Autor:Kim JY; Lee JH; Lee CS; Lee SC
[Ad] Endereço:Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul, South Korea.
[Ti] Título:Varicella zoster virus-associated Chorioretinitis: a case report.
[So] Source:BMC Ophthalmol;18(1):28, 2018 Feb 05.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained during the course of resolution. CASE PRESENTATION: A 61-year-old woman presented with acute, unilateral vision loss in her right eye. Her visual acuity was count fingers in the right eye and 16/20 in the left eye, and she exhibited skin vesicles on her right forehead. Slit lamp biomicroscopy, funduscopy, OCT, and intraocular fluid analysis were performed. The right eye exhibited multiple inflammatory lesions at the posterior pole, macular edema, and disc swelling on the fundus examination. OCT revealed predominant involvement of the choroid and the retinal pigment epithelium (RPE). Intraocular fluid analysis showed positivity for VZV. The patient was admitted and treated with intravenous acyclovir. Additional oral prednisolone was used to reduce the inflammatory reaction. After 2 weeks of treatment with acyclovir, the lesion resolved, with undulation of the RPE. Her final visual acuity was 20/20. CONCLUSIONS: VZV-associated posterior uveitis may present as multifocal chorioretinitis. Intraocular fluid analysis is important to detect an infectious origin.
[Mh] Termos MeSH primário: Coriorretinite/virologia
Infecções Oculares Virais/virologia
Herpesvirus Humano 3/isolamento & purificação
Uveíte Posterior/virologia
Infecção pelo Vírus da Varicela-Zoster/virologia
[Mh] Termos MeSH secundário: Aciclovir/uso terapêutico
Administração Oral
Antivirais/uso terapêutico
Coriorretinite/diagnóstico
Coriorretinite/tratamento farmacológico
Terapia Combinada
Infecções Oculares Virais/diagnóstico
Infecções Oculares Virais/tratamento farmacológico
Feminino
Angiofluoresceinografia
Glucocorticoides/uso terapêutico
Seres Humanos
Meia-Idade
Prednisolona/uso terapêutico
Tomografia de Coerência Óptica
Uveíte Posterior/diagnóstico
Uveíte Posterior/tratamento farmacológico
Infecção pelo Vírus da Varicela-Zoster/diagnóstico
Infecção pelo Vírus da Varicela-Zoster/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Glucocorticoids); 9PHQ9Y1OLM (Prednisolone); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0696-3


  3 / 8309 MEDLINE  
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[PMID]:29074089
[Au] Autor:Fujii H; Kakiuchi S; Tsuji M; Nishimura H; Yoshikawa T; Yamada S; Omura N; Inagaki T; Shibamura M; Harada S; Taniguchi S; Saijo M
[Ad] Endereço:Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
[Ti] Título:Application of next-generation sequencing to detect acyclovir-resistant herpes simplex virus type 1 variants at low frequency in thymidine kinase gene of the isolates recovered from patients with hematopoietic stem cell transplantation.
[So] Source:J Virol Methods;251:123-128, 2018 Jan.
[Is] ISSN:1879-0984
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ion Torrent next-generation sequencing (NGS) technology was applied to study the mode of emergence of acyclovir (ACV)-resistant (ACVr) herpes simplex virus type 1 (HSV-1) in patients with hematopoietic stem cell transplantation (HSCT) by quantitatively detecting mutations in the viral thymidine kinase (vTK) gene in the HSV-1 isolates recovered from HSCT patients. All of the mutations detected with the Sanger sequencing method in the vTK genes of HSV-1 isolates were also detected with the NGS assay. Furthermore, different mutations, which conferred ACV resistance and were not detected with the Sanger sequencing method, were also detected in a quantitative manner by using the NGS assay. The approach described here is applicable to studying the emergence process of vTK gene mutation-associated ACVr HSV-1 more in detail than the Sanger method. The NGS assay makes it possible to make a diagnosis of vTK gene mutation-associated ACVr HSV-1 infections at the early stage, which the ratio of ACVr HSV-1 is much lower than that of ACV-sensitive (ACVs) HSV-1.
[Mh] Termos MeSH primário: Aciclovir/farmacologia
Antivirais/farmacologia
Farmacorresistência Viral
Técnicas de Genotipagem/métodos
Herpesvirus Humano 1/efeitos dos fármacos
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Testes de Sensibilidade Microbiana/métodos
[Mh] Termos MeSH secundário: Transplante de Células-Tronco Hematopoéticas
Herpes Simples/virologia
Herpesvirus Humano 1/enzimologia
Herpesvirus Humano 1/genética
Seres Humanos
Mutação
Timidina Quinase/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); EC 2.7.1.21 (Thymidine Kinase); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171028
[St] Status:MEDLINE


  4 / 8309 MEDLINE  
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[PMID]:28460866
[Au] Autor:Lubomski M; Brown L; Markus R
[Ad] Endereço:Department of Neurology, St Vincent's Hospital, 390 Victoria St, Darlinghurst, NSW, 2010 Sydney, Australia; The University of Notre Dame Australia, School of Medicine, Sydney, 160 Oxford St, Darlinghurst, NSW, 2010 Sydney, Australia. Electronic address: michal.lubomski@nd.edu.au.
[Ti] Título:An unusual presentation of varicella zoster virus with acute cerebellitis and SIADH without a rash.
[So] Source:J Clin Neurosci;41:90-91, 2017 Jul.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:We report a case of varicella-zoster virus (VZV) infection with acute cerebellitis and encephalitis with associated Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in an elderly man presenting with acute cerebellar ataxia without antecedent rash. Cerebrospinal fluid examination (CSF) revealed a mononuclear pleocytosis, high protein, normal glucose, positive for VZV polymerase chain reaction (PCR). Early acyclovir treatment is beneficial for acute VZV cerebellitis. Clinicians should consider infectious Central Nervous System (CNS) causes for presentations of acute cerebellar ataxia in adult patients, particularly if there is an accompanying clouded sensorium.
[Mh] Termos MeSH primário: Encefalite por Varicela Zoster/diagnóstico
Síndrome de Secreção Inadequada de HAD/diagnóstico
[Mh] Termos MeSH secundário: Aciclovir/uso terapêutico
Idoso de 80 Anos ou mais
Antivirais/uso terapêutico
Cerebelo/patologia
Encefalite por Varicela Zoster/tratamento farmacológico
Exantema/diagnóstico
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  5 / 8309 MEDLINE  
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[PMID]:27777201
[Au] Autor:Cui JZ; Zhang JW; Zhang Y; Ma ZL
[Ad] Endereço:Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China. E-mail: cuijizheng@126.com.
[Ti] Título:[Efficacy of intracutaneous methylene blue injection for moderate to severe acute thoracic herpes zoster pain and prevention of postherpetic neuralgia in elderly patients].
[So] Source:Nan Fang Yi Ke Da Xue Xue Bao;36(10):1377-1381, 2016 Oct 20.
[Is] ISSN:1673-4254
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To evaluate the clinical efficacy of intradermal injection of methylene blue for treatment of moderate to severe acute thoracic herpes zoster and prevention of postherpetica neuralgia in elderly patients. METHODS: Sixty-four elderly patients with herpes zoster were randomized to receive a 10-day course of intradermal injection of methylene blue and lidocaine plus oral valaciclovir (group A, 32 cases) and intradermal injection of lidocaine plus oral valaciclovir (group B).Herpes evaluation index, pain rating index, incidence of postherpetic neuralgia, and comprehensive therapeutic effect were compared between the two groups at 11, 30 and 60 days after the treatment. RESULTS: The baseline characteristics were comparable between the two groups (all P>0.05). Compared with that in group B, the time for no new blister formation, blister incrustation and decrustation, and pain relief was significantly shortened in group A (P<0.05) with also obviously lower pain intensity after the treatment. The incidence of postherpetic neuralgia was significantly lower in group A than in group B at 30 days (P<0.05), but not at 60 and 90 days after the treatment. The total clinical response rate was 93.8% in group A, much higher than that in group B (62.5%, P<0.05). CONCLUSION: Intradermal injection of methylene blue can effectively shorten the disease course, reduce the pain intensity and prevent the development of postherpetic neuralgia in elderly patients with herpes zoster.
[Mh] Termos MeSH primário: Herpes Zoster/complicações
Azul de Metileno/administração & dosagem
Neuralgia Pós-Herpética/terapia
[Mh] Termos MeSH secundário: Aciclovir/administração & dosagem
Aciclovir/análogos & derivados
Aciclovir/uso terapêutico
Idoso
Seres Humanos
Incidência
Injeções Intradérmicas
Lidocaína/administração & dosagem
Lidocaína/uso terapêutico
Azul de Metileno/uso terapêutico
Medição da Dor
Valina/administração & dosagem
Valina/análogos & derivados
Valina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
98PI200987 (Lidocaine); HG18B9YRS7 (Valine); MZ1IW7Q79D (valacyclovir); T42P99266K (Methylene Blue); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  6 / 8309 MEDLINE  
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[PMID]:28985573
[Au] Autor:Bauer D; Keller J; Alt M; Schubert A; Aufderhorst UW; Palapys V; Kasper M; Heilingloh CS; Dittmer U; Laffer B; Eis-Hübinger AM; Verjans GM; Heiligenhaus A; Roggendorf M; Krawczyk A
[Ad] Endereço:Ophtha-Lab, Department of Ophthalmology at St. Franziskus Hospital, Muenster, Germany.
[Ti] Título:Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections.
[So] Source:Virology;512:194-200, 2017 Dec.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The increasing incidence of aciclovir- (ACV) resistant strains in patients with ocular herpes simplex virus (HSV) infections is a major health problem in industrialized countries. In the present study, the humanized monoclonal antibody (mAb) hu2c targeting the HSV-1/2 glycoprotein B was examined for its efficacy towards ACV-resistant infections of the eye in the mouse model of acute retinal necrosis (ARN). BALB/c mice were infected by microinjection of an ACV-resistant clinical isolate into the anterior eye chamber to induce ARN and systemically treated with mAb hu2c at 24h prior (pre-exposure prophylaxis) or at 24, 40, and 56h after infection (post-exposure immunotherapy). Mock treated controls and ACV-treated mice showed pronounced retinal damage. Mice treated with mAb hu2c were almost completely protected from developing ARN. In conclusion, mAb hu2c may become a reliable therapeutic option for drug/ACV-resistant ocular HSV infections in humans in order to prevent blindness.
[Mh] Termos MeSH primário: Aciclovir/farmacologia
Anticorpos Monoclonais/uso terapêutico
Anticorpos Antivirais/imunologia
Herpesviridae/efeitos dos fármacos
Imunoterapia
Retinite/virologia
[Mh] Termos MeSH secundário: Animais
Antivirais/farmacologia
Farmacorresistência Viral
Feminino
Herpesviridae/imunologia
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Retinite/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antibodies, Viral); 0 (Antiviral Agents); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  7 / 8309 MEDLINE  
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[PMID]:28943043
[Au] Autor:Brown CE; Kong T; McNulty J; D'Aiuto L; Williamson K; McClain L; Piazza P; Nimgaonkar VL
[Ad] Endereço:Department of Chemistry & Chemical Biology, McMaster University, Hamilton, Ontario L8S 4M1, Canada.
[Ti] Título:Discovery of potent antiviral (HSV-1) quinazolinones and initial structure-activity relationship studies.
[So] Source:Bioorg Med Chem Lett;27(20):4601-4605, 2017 10 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The discovery of antiviral activity of 2,3-disubstituted quinazolinones, prepared by a one-pot, three-component condensation of isatoic anhydride with amines and aldehydes, against Herpes Simplex Virus (HSV)-1 is reported. Sequential iterative synthesis/antiviral assessment allowed structure-activity relationship (SAR) generation revealing synergistic structural features required for potent anti-HSV-1 activity. The most potent derivatives show greater efficacy than acyclovir against acute HSV-1 infections in neurons and minimal toxicity to the host.
[Mh] Termos MeSH primário: Herpesvirus Humano 1/efeitos dos fármacos
Quinazolinonas/química
Quinazolinonas/farmacologia
[Mh] Termos MeSH secundário: Aciclovir/farmacologia
Animais
Antivirais/química
Antivirais/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Cercopithecus aethiops
Imunoprecipitação da Cromatina
Avaliação Pré-Clínica de Medicamentos
Seres Humanos
Relação Estrutura-Atividade
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Quinazolinones); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE


  8 / 8309 MEDLINE  
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[PMID]:28829913
[Au] Autor:Derudas M; Vanpouille C; Carta D; Zicari S; Andrei G; Snoeck R; Brancale A; Margolis L; Balzarini J; McGuigan C
[Ad] Endereço:Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University , Cardiff, CF10 3NB, U.K.
[Ti] Título:Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides.
[So] Source:J Med Chem;60(18):7876-7896, 2017 Sep 28.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Following our findings on the anti-human immunodeficiency virus (HIV) activity of acyclovir (ACV) phosphate prodrugs, we herein report the ProTide approach applied to a series of acyclic nucleosides aimed at the identification of novel and selective antiviral, in particular anti-HIV agents. Acyclic nucleoside analogues used in this study were identified through a virtual screening using HIV-reverse transcriptase (RT), adenylate/guanylate kinase, and human DNA polymerase γ. A total of 39 new phosphate prodrugs were synthesized and evaluated against HIV-1 (in vitro and ex vivo human tonsillar tissue system) and human herpes viruses. Several ProTide compounds showed substantial potency against HIV-1 at low micromolar range while the parent nucleosides were not effective. Also, pronounced inhibition of herpesvirus replication was observed. A carboxypeptidase-mediated hydrolysis study was performed for a selection of compounds to assess the formation of putative metabolites and support the biological activity observed.
[Mh] Termos MeSH primário: Aciclovir/análogos & derivados
Aciclovir/farmacologia
Fármacos Anti-HIV/química
Fármacos Anti-HIV/farmacologia
HIV-1/efeitos dos fármacos
Nucleosídeos/química
Nucleosídeos/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular
Desenho de Drogas
Infecções por HIV/tratamento farmacológico
Infecções por HIV/virologia
Transcriptase Reversa do HIV/metabolismo
HIV-1/enzimologia
Herpes Simples/tratamento farmacológico
Herpes Simples/virologia
Seres Humanos
Simulação de Acoplamento Molecular
Simplexvirus/efeitos dos fármacos
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Nucleosides); EC 2.7.7.49 (HIV Reverse Transcriptase); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.7b01009


  9 / 8309 MEDLINE  
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[PMID]:28665969
[Au] Autor:Houston DMJ; Bugert JJ; Denyer SP; Heard CM
[Ad] Endereço:School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff Wales, United Kingdom.
[Ti] Título:Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV.
[So] Source:PLoS One;12(6):e0179291, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is a clinical need for new therapeutic products against Herpes simplex virus (HSV). The pomegranate, fruit of the tree Punica granatum L, has since ancient times been linked to activity against infection. This work probed the activity of pomegranate rind extract (PRE) and co-administered zinc (II) ions. MATERIALS AND METHODS: PRE was used in conjunction with zinc (II) salts to challenge HSV-1 and aciclovir-resistant HSV in terms of virucidal plaque assay reduction and antiviral activities in epithelial Vero host cells. Cytotoxicity was determined by the MTS assay using a commercial kit. RESULTS: Zinc sulphate, zinc citrate, zinc stearate and zinc gluconate demonstrated similar potentiated virucidal activity with PRE against HSV-1 by up to 4-fold. A generally parabolic relationship was observed when HSV-1 was challenged with PRE and varying concentrations of ZnSO4, with a maximum potentiation factor of 5.5. Punicalagin had 8-fold greater virucidal activity than an equivalent mass of PRE. However, antiviral data showed that punicalagin had significantly lower antiviral activity compared to the activity of PRE (EC50 = 0.56 µg mL-1) a value comparable to aciclovir (EC50 = 0.18 µg mL-1); however, PRE also demonstrated potency against aciclovir-resistant HSV (EC50 = 0.02 µg mL-1), whereas aciclovir showed no activity. Antiviral action of PRE was not influenced by ZnSO4. No cytotoxicity was detected with any test solution. CONCLUSIONS: The potentiated virucidal activity of PRE by coadministered zinc (II) has potential as a multi-action novel topical therapeutic agent against HSV infections, such as coldsores.
[Mh] Termos MeSH primário: Aciclovir/farmacologia
Antivirais/farmacologia
Herpesvirus Humano 1/efeitos dos fármacos
Herpesvirus Humano 2/efeitos dos fármacos
Extratos Vegetais/farmacologia
Punicaceae/química
Compostos de Zinco/farmacologia
[Mh] Termos MeSH secundário: Animais
Antivirais/administração & dosagem
Cercopithecus aethiops
Citotoxicidade Imunológica/efeitos dos fármacos
Farmacorresistência Viral
Sinergismo Farmacológico
Ácido Elágico/farmacologia
Herpesvirus Humano 1/crescimento & desenvolvimento
Herpesvirus Humano 2/crescimento & desenvolvimento
Extratos Vegetais/administração & dosagem
Células Vero
Ensaio de Placa Viral
Compostos de Zinco/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Plant Extracts); 0 (Zinc Compounds); 19YRN3ZS9P (Ellagic Acid); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179291


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[PMID]:28637937
[Au] Autor:Tsuboguchi S; Wakasugi T; Umeda Y; Umeda M; Oyake M; Fujita N
[Ad] Endereço:Department of Neurology, Nagaoka Red Cross Hospital.
[Ti] Título:Herpes simplex encephalitis presenting as stroke-like symptoms with atypical MRI findings and lacking cerebrospinal fluid pleocytosis.
[So] Source:Rinsho Shinkeigaku;57(7):387-390, 2017 07 29.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 73-year-old woman presented with sudden onset of right hemiparesis and was diagnosed as having cerebral infarction on the basis of diffusion-weighted brain MRI, which demonstrated lesions in the left parietal cortex. On the 3rd day, the patient developed right upper limb myoclonus, aphasia, and disturbance of consciousness with high fever. On the 6th day, she was transferred to our hospital with suspected viral encephalitis, and treatment with acyclovir was started. By the 6th day, the lesions detected by MRI had expanded to the gyrus cinguli, insula and thalamus, but not to the temporal lobe. At that time, the CSF cell count was 8/µl, and this later increased to 17/µl by the 13th day. Although herpes simplex virus DNA was detected in the CSF on the 6th day, there was no evidence of CSF pleocytosis or temporal lobe abnormalities demonstrable by brain MRI throughout the whole follow-up period. This was very atypical case of herpes simplex encephalitis characterized by a stroke-like episode, atypical MRI findings, and absence of cerebrospinal fluid pleocytosis. It is important to be mindful that herpes simplex encephalitis (HSE) can have an atypical presentation, and that sufficient acyclovir treatment should be initiated until HSE can be ruled out.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Encefalite por Herpes Simples/complicações
Encefalite por Herpes Simples/diagnóstico por imagem
Imagem por Ressonância Magnética
Neuroimagem
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Aciclovir/administração & dosagem
Idoso
Antivirais/administração & dosagem
Biomarcadores/líquido cefalorraquidiano
Clonazepam/administração & dosagem
DNA Viral/líquido cefalorraquidiano
Quimioterapia Combinada
Encefalite por Herpes Simples/líquido cefalorraquidiano
Encefalite por Herpes Simples/tratamento farmacológico
Feminino
Seres Humanos
Leucocitose/líquido cefalorraquidiano
Metilprednisolona/administração & dosagem
Piracetam/administração & dosagem
Piracetam/análogos & derivados
Simplexvirus/genética
Acidente Vascular Cerebral/líquido cefalorraquidiano
Acidente Vascular Cerebral/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Biomarkers); 0 (DNA, Viral); 230447L0GL (etiracetam); 5PE9FDE8GB (Clonazepam); X4HES1O11F (Acyclovir); X4W7ZR7023 (Methylprednisolone); ZH516LNZ10 (Piracetam)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001033



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