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Pesquisa : D03.633.100.759.758.824.751.250 [Categoria DeCS]
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  1 / 104 MEDLINE  
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[PMID]:27113866
[Au] Autor:Verstraete G; Van Renterghem J; Van Bockstal PJ; Kasmi S; De Geest BG; De Beer T; Remon JP; Vervaet C
[Ad] Endereço:Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
[Ti] Título:Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding.
[So] Source:Int J Pharm;506(1-2):214-21, 2016 Jun 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hydrophilic aliphatic thermoplastic polyurethane (Tecophilic™ grades) matrices for high drug loaded oral sustained release dosage forms were formulated via hot melt extrusion/injection molding (HME/IM). Drugs with different aqueous solubility (diprophylline, theophylline and acetaminophen) were processed and their influence on the release kinetics was investigated. Moreover, the effect of Tecophilic™ grade, HME/IM process temperature, extrusion speed, drug load, injection pressure and post-injection pressure on in vitro release kinetics was evaluated for all model drugs. (1)H NMR spectroscopy indicated that all grades have different soft segment/hard segment ratios, allowing different water uptake capacities and thus different release kinetics. Processing temperature of the different Tecophilic™ grades was successfully predicted by using SEC and rheology. Tecophilic™ grades SP60D60, SP93A100 and TG2000 had a lower processing temperature than other grades and were further evaluated for the production of IM tablets. During HME/IM drug loads up to 70% (w/w) were achieved. In addition, Raman mapping and (M)DSC results confirmed the homogenous distribution of mainly crystalline API in all polymer matrices. Besides, hydrophilic TPU based formulations allowed complete and sustained release kinetics without using release modifiers. As release kinetics were mainly affected by drug load and the length of the PEO soft segment, this polymer platform offers a versatile formulation strategy to adjust the release rate of drugs with different aqueous solubility.
[Mh] Termos MeSH primário: Acetaminofen/administração & dosagem
Difilina/administração & dosagem
Poliuretanos/química
Teofilina/administração & dosagem
[Mh] Termos MeSH secundário: Acetaminofen/química
Administração Oral
Química Farmacêutica/métodos
Cristalização
Preparações de Ação Retardada
Portadores de Fármacos/química
Liberação Controlada de Fármacos
Difilina/química
Interações Hidrofóbicas e Hidrofílicas
Espectroscopia de Ressonância Magnética
Solubilidade
Comprimidos
Tecnologia Farmacêutica/métodos
Teofilina/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Drug Carriers); 0 (Polyurethanes); 0 (Tablets); 263T0E9RR9 (Dyphylline); 362O9ITL9D (Acetaminophen); C137DTR5RG (Theophylline)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160427
[St] Status:MEDLINE


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[PMID]:25448075
[Au] Autor:Claeys B; Vervaeck A; Hillewaere XK; Possemiers S; Hansen L; De Beer T; Remon JP; Vervaet C
[Ad] Endereço:Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ghent, Belgium.
[Ti] Título:Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding.
[So] Source:Eur J Pharm Biopharm;90:44-52, 2015 Feb.
[Is] ISSN:1873-3441
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study evaluated thermoplastic polyurethanes (TPUR) as matrix excipients for the production of oral solid dosage forms via hot melt extrusion (HME) in combination with injection molding (IM). We demonstrated that TPURs enable the production of solid dispersions - crystalline API in a crystalline carrier - at an extrusion temperature below the drug melting temperature (Tm) with a drug content up to 65% (wt.%). The release of metoprolol tartrate was controlled over 24h, whereas a complete release of diprophylline was only possible in combination with a drug release modifier: polyethylene glycol 4000 (PEG 4000) or Tween 80. No burst release nor a change in tablet size and geometry was detected for any of the formulations after dissolution testing. The total matrix porosity increased gradually upon drug release. Oral administration of TPUR did not affect the GI ecosystem (pH, bacterial count, short chain fatty acids), monitored via the Simulator of the Human Intestinal Microbial Ecosystem (SHIME). The high drug load (65 wt.%) in combination with (in vitro and in vivo) controlled release capacity of the formulations, is noteworthy in the field of formulations produced via HME/IM.
[Mh] Termos MeSH primário: Preparações de Ação Retardada/administração & dosagem
Preparações de Ação Retardada/química
Poliuretanos/administração & dosagem
Poliuretanos/química
[Mh] Termos MeSH secundário: Administração Oral
Química Farmacêutica/métodos
Formas de Dosagem
Portadores de Fármacos/administração & dosagem
Portadores de Fármacos/química
Composição de Medicamentos/métodos
Difilina/administração & dosagem
Difilina/química
Excipientes/química
Temperatura Alta
Seres Humanos
Metoprolol/administração & dosagem
Metoprolol/química
Polietilenoglicóis/administração & dosagem
Polietilenoglicóis/química
Porosidade
Comprimidos/administração & dosagem
Comprimidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Dosage Forms); 0 (Drug Carriers); 0 (Excipients); 0 (Polyurethanes); 0 (Tablets); 263T0E9RR9 (Dyphylline); 30IQX730WE (Polyethylene Glycols); GEB06NHM23 (Metoprolol)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150316
[Lr] Data última revisão:
150316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


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[PMID]:25445517
[Au] Autor:Claeys B; De Bruyn S; Hansen L; De Beer T; Remon JP; Vervaet C
[Ad] Endereço:Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
[Ti] Título:Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers - a case study with diprophylline.
[So] Source:Int J Pharm;477(1-2):244-50, 2014 Dec 30.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The influence of several dicarboxylic acids on the release characteristics of polyurethane tablets with a high drug load was investigated. Mixtures of diprophylline (Dyph) and thermoplastic polyurethane (TPUR) (ratio: 50/50, 65/35 and 75/25 wt.%) were hot-melt extruded and injection molded with the addition of 1, 2.5, 5 and 10% wt.% dicarboxylic acid as release modifier. Incorporating malonic, succinic, maleic and glutaric acid in the TPUR matrices enhanced drug release, proportional to the dicarboxylic acid concentration in the formulation. No correlation was found between the water solubility, melting point, logP and pKa of the acids and their drug release modifying capacity. Succinic and maleic acid had the highest drug release modifying capacity which was linked to more intense molecular interactions with Dyph. A structural fit between the primary and secondary alcohol of Dyph and both carboxylic groups of the acids was at the origin of this enhanced interaction.
[Mh] Termos MeSH primário: Ácidos Dicarboxílicos/química
Portadores de Fármacos/química
Difilina/administração & dosagem
Poliuretanos/química
[Mh] Termos MeSH secundário: Composição de Medicamentos
Liberação Controlada de Fármacos
Difilina/química
Estrutura Molecular
Espectroscopia de Infravermelho com Transformada de Fourier
Comprimidos
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dicarboxylic Acids); 0 (Drug Carriers); 0 (Polyurethanes); 0 (Tablets); 263T0E9RR9 (Dyphylline); 76600-67-4 (Tecoflex)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141216
[Lr] Data última revisão:
141216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


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[PMID]:24746409
[Au] Autor:Grund J; Koerber M; Walther M; Bodmeier R
[Ad] Endereço:College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, Berlin 12169, Germany.
[Ti] Título:The effect of polymer properties on direct compression and drug release from water-insoluble controlled release matrix tablets.
[So] Source:Int J Pharm;469(1):94-101, 2014 Jul 20.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to identify and evaluate key polymer properties affecting direct compression and drug release from water-insoluble matrices. Commonly used polymers, such as Kollidon(®) SR, Eudragit(®) RS and ethyl cellulose, were characterized, formulated into tablets and compared with regard to their properties in dry and wet state. A similar site percolation threshold of 65% v/v was found for all polymers in dry state. Key parameters influencing polymer compactibility were the surface properties and the glass transition temperature (T(g)), affecting polymer elasticity and particle size-dependent binding. The important properties observed in dry state also governed matrix characteristics and therefore drug release in wet state. A low T(g) (Kollidon(®) SR
[Mh] Termos MeSH primário: Portadores de Fármacos
Difilina/química
Polímeros/química
Água/química
[Mh] Termos MeSH secundário: Resinas Acrílicas/química
Celulose/análogos & derivados
Celulose/química
Química Farmacêutica
Força Compressiva
Preparações de Ação Retardada
Elasticidade
Temperatura Alta
Umidade
Cinética
Tamanho da Partícula
Permeabilidade
Porosidade
Povidona/química
Solubilidade
Propriedades de Superfície
Comprimidos
Tecnologia Farmacêutica/métodos
Temperatura de Transição
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Delayed-Action Preparations); 0 (Drug Carriers); 0 (Polymers); 0 (Tablets); 059QF0KO0R (Water); 263T0E9RR9 (Dyphylline); 33434-24-1 (Eudragit RS); 7Z8S9VYZ4B (ethyl cellulose); 9004-34-6 (Cellulose); FZ989GH94E (Povidone)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140422
[St] Status:MEDLINE


  5 / 104 MEDLINE  
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[PMID]:24268271
[Au] Autor:Hasimi A; Papadokostaki KG; Sanopoulou M
[Ad] Endereço:Dept. of Physical Chemistry, Institute of Advanced Materials, Physicochemical Processes, Nanotechnology and Microsystems, National Center for Scientific Research "Demokritos", 15310 Ag. Paraskevi, Athens, Greece.
[Ti] Título:Mechanisms of diphylline release from dual-solute loaded poly(vinyl alcohol) matrices.
[So] Source:Mater Sci Eng C Mater Biol Appl;34:369-76, 2014 Jan 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The release kinetics of the model hydrophilic drug, diphylline (DPL), from physically crosslinked poly(vinyl alcohol) (PVA) matrices, is studied in relation to the drug load and the presence of a second solute incorporated in the matrix. The second solute, a gadolinium (III) complex (Gd-DTPA), is a commonly used MRI contrast agent. The water uptake kinetics by the glassy PVA matrix was found to deviate from t(1/2) law and to occur on time scales comparable to those of diphylline release. The corresponding rate of diphylline release was found to be substantially stabilized as compared to a purely diffusion-controlled release process, in line with theoretical predictions under conditions of relaxation-controlled water uptake kinetics. The release rate of DPL was found (i) to increase with increasing DPL load and (ii) for a particular DPL load, to increase in the presence of Gd-DTPA, incorporated in the matrix. The results were interpreted on the basis of the diphylline-induced plasticization of the polymer (evidenced by the depression of Tg) and of the excess hydration of the matrix at high solute loads. The latter effect was found to be additive in the case of dual-solute loaded matrices.
[Mh] Termos MeSH primário: Portadores de Fármacos/química
Difilina/química
Álcool de Polivinil/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Gadolínio/química
Cinética
Peso Molecular
Temperatura Ambiente
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drug Carriers); 059QF0KO0R (Water); 263T0E9RR9 (Dyphylline); 9002-89-5 (Polyvinyl Alcohol); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:131125
[Lr] Data última revisão:
131125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131126
[St] Status:MEDLINE


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[PMID]:24060762
[Au] Autor:Yokose C; Nakai N; Katoh N
[Ad] Endereço:Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.
[Ti] Título:Maculopapular-type drug eruption caused by Coughcode(®)-N combination tablets.
[So] Source:Allergol Int;62(4):519-21, 2013 Dec.
[Is] ISSN:1440-1592
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Acetaminofen/efeitos adversos
Antitussígenos/efeitos adversos
Bromisoval/efeitos adversos
Codeína/análogos & derivados
Difenidramina/efeitos adversos
Erupção por Droga/diagnóstico
Erupção por Droga/etiologia
Difilina/efeitos adversos
Efedrina/análogos & derivados
[Mh] Termos MeSH secundário: Acetaminofen/administração & dosagem
Administração Oral
Adolescente
Antitussígenos/administração & dosagem
Bromisoval/administração & dosagem
Codeína/administração & dosagem
Codeína/efeitos adversos
Difenidramina/administração & dosagem
Combinação de Medicamentos
Difilina/administração & dosagem
Eosinófilos/imunologia
Efedrina/administração & dosagem
Efedrina/efeitos adversos
Feminino
Seres Humanos
Imunização
Testes Cutâneos
Comprimidos
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Antitussive Agents); 0 (Drug Combinations); 0 (Tablets); 0 (coughcode-N); 263T0E9RR9 (Dyphylline); 362O9ITL9D (Acetaminophen); 469GW8R486 (Bromisovalum); 8GTS82S83M (Diphenhydramine); GN83C131XS (Ephedrine); Q830PW7520 (Codeine)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:131127
[Lr] Data última revisão:
131127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130925
[St] Status:MEDLINE
[do] DOI:10.2332/allergolint.13-LE-0558


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[PMID]:23984951
[Au] Autor:Brandel C; Amharar Y; Rollinger JM; Griesser UJ; Cartigny Y; Petit S; Coquerel G
[Ad] Endereço:Unité de Cristallogenèse, SMS, EA 3233, Université de Rouen , PRES Normandie Université , F-76821 Mont-Saint-Aignan Cedex, France.
[Ti] Título:Impact of molecular flexibility on double polymorphism, solid solutions and chiral discrimination during crystallization of diprophylline enantiomers.
[So] Source:Mol Pharm;10(10):3850-61, 2013 Oct 07.
[Is] ISSN:1543-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The polymorphic behavior of racemic and enantiopure diprophylline (DPL), a chiral derivative of theophylline marketed as a racemic solid, has been investigated by combining differential scanning calorimetry, powder X-ray diffraction, hot-stage microscopy and single-crystal X-ray experiments. The pure enantiomers were obtained by a chemical synthesis route, and additionally an enantioselective crystallization procedure was developed. The binary phase diagram between the DPL enantiomers was constructed and revealed a double polymorphism (i.e., polymorphism both of the racemic mixture and of the pure enantiomer). The study of the various equilibria in this highly unusual phase diagram revealed a complex situation since mixtures of DPL enantiomers can crystallize either as a stable racemic compound, a metastable conglomerate, or two distinct metastable solid solutions. Crystal structure analysis revealed that the DPL molecules adopt different conformations in the crystal forms suggesting that the conformational degrees of freedom of the substituent that carries the only two H-bond donor groups might be related to the versatile crystallization behavior of DPL. The control of these equilibria and the use of a suitable solvent allowed the design of an efficient protocol for the preparative resolution of racemic DPL via preferential crystallization. Therefore, the resolution of DPL enantiomers despite the existence of a racemic compound stable at any temperature demonstrates that the detection of a stable conglomerate is not mandatory for the implementation of preferential crystallization.
[Mh] Termos MeSH primário: Difilina/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Cristalização
Estrutura Molecular
Conformação Proteica
Estereoisomerismo
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
263T0E9RR9 (Dyphylline)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:131007
[Lr] Data última revisão:
131007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130830
[St] Status:MEDLINE
[do] DOI:10.1021/mp400308u


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[PMID]:23454846
[Au] Autor:Wang R; Xie Y; Zhang Y; Kang X; Wang X; Ge B; Chang J
[Ad] Endereço:Department of Chemistry, Zhengzhou University, Zhengzhou 450001, China. wangry@zzu.edu.cn
[Ti] Título:Comparative study of the binding of pepsin to four alkaloids by spectrofluorimetry.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;108:62-74, 2013 May.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The interactions between pepsin and four alkaloids, including caffeine (Caf), aminophylline (Ami), acefylline (Ace), diprophylline (Dip), were investigated by fluorescence, UV-visible absorption, resonance light scattering, synchronous fluorescence spectroscopy and 3D spectroscopy under mimic physiological conditions. The results revealed that Caf (Ami/Ace/Dip) caused the fluorescence quenching of pepsin by the formation of Caf (Ami/Ace/Dip)-pepsin complex. The binding constants and thermodynamic parameters at three different temperatures, the binding locality and the binding power were obtained. The hydrophobic and electrostatic interactions were the predominant intermolecular forces to stabilize the complex. Results showed that aminophylline was the stronger quencher and bound to pepsin with higher affinity than other three alkaloids.
[Mh] Termos MeSH primário: Alcaloides/metabolismo
Pepsina A/metabolismo
[Mh] Termos MeSH secundário: Absorção
Alcaloides/química
Aminofilina/química
Aminofilina/metabolismo
Cafeína/química
Cafeína/metabolismo
Difilina/química
Difilina/metabolismo
Transferência de Energia
Concentração de Íons de Hidrogênio
Cinética
Luz
Ligação Proteica
Conformação Proteica
Espalhamento de Radiação
Espectrometria de Fluorescência
Espectrofotometria Ultravioleta
Temperatura Ambiente
Teofilina/análogos & derivados
Teofilina/química
Teofilina/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 263T0E9RR9 (Dyphylline); 27Y3KJK423 (Aminophylline); 3G6A5W338E (Caffeine); C137DTR5RG (Theophylline); EC 3.4.23.1 (Pepsin A); M494UE2YEP (acefylline)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130305
[St] Status:MEDLINE


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[PMID]:23266670
[Au] Autor:Wang RQ; Yin YJ; Li H; Wang Y; Pu JJ; Wang R; Dou HJ; Song CJ; Wang RY
[Ad] Endereço:The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
[Ti] Título:Comparative study of the interactions between ovalbumin and three alkaloids by spectrofluorimetry.
[So] Source:Mol Biol Rep;40(4):3409-18, 2013 Apr.
[Is] ISSN:1573-4978
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The interaction between ovalbumin (OVA) and three purine alkaloids (caffeine, theophylline and diprophylline) was investigated by the aid of intrinsic and synchronous fluorescence, ultraviolet-vis absorbance, resonance light-scattering spectra and three-dimensional fluorescence spectra techniques. Results showed that the formation of complexes gave rise to the fluorescence quenching of OVA by caffeine, theophylline, and diprophylline. Static quenching was confirmed to results in the fluorescence quenching. The binding site number n, apparent binding constant KA and corresponding thermodynamic parameters were measured at different temperatures. The binding process was spontaneous molecular interaction procedures in which both enthalpy and Gibbs free energy decreased. Van der Waals forces and hydrogen bond played a major role in stabilizing the complex. The comparison between caffeine, theophylline, and diprophylline was made, and thermodynamic results showed that diprophylline was the strongest quencher and bound to OVA with the highest affinity among three compounds. The influence of molecular structure on the binding aspects was reported.
[Mh] Termos MeSH primário: Cafeína/química
Difilina/química
Ovalbumina/química
Teofilina/química
[Mh] Termos MeSH secundário: Sítios de Ligação
Fluorescência
Ligações de Hidrogênio
Estrutura Molecular
Ligação Proteica
Espectrometria de Fluorescência
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
263T0E9RR9 (Dyphylline); 3G6A5W338E (Caffeine); 9006-59-1 (Ovalbumin); C137DTR5RG (Theophylline)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121226
[St] Status:MEDLINE
[do] DOI:10.1007/s11033-012-2418-x


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[PMID]:22728260
[Au] Autor:Güres S; Mendyk A; Jachowicz R; Dorozynski P; Kleinebudde P
[Ad] Endereço:Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University of Düsseldorf, Universitätsstr. 1, 40225 Duesseldorf, Germany.
[Ti] Título:Application of artificial neural networks (ANNs) and genetic programming (GP) for prediction of drug release from solid lipid matrices.
[So] Source:Int J Pharm;436(1-2):877-9, 2012 Oct 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to develop a semi-empirical mathematical model, which is able to predict the release profiles of solid lipid extrudates of different dimensions. The development of the model was based on the application of ANNs and GP. ANNs' abilities to deal with multidimensional data were exploited. GP programming was used to determine the constants of the model function, a modified Weibull equation. Differently dimensioned extrudates consisting of diprophylline, tristearin and polyethylene glycol were produced by the use of a twin-screw extruder and their dissolution behaviour was studied. Experimentally obtained dissolution curves were compared to the calculated release profiles, derived from the semi-empirical mathematical model.
[Mh] Termos MeSH primário: Difilina/química
Modelos Teóricos
Redes Neurais (Computação)
Polietilenoglicóis/química
Triglicerídeos/química
[Mh] Termos MeSH secundário: Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Triglycerides); 263T0E9RR9 (Dyphylline); 30IQX730WE (Polyethylene Glycols); P6OCJ2551R (tristearin)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120626
[St] Status:MEDLINE
[do] DOI:10.1016/j.ijpharm.2012.05.021



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