Base de dados : MEDLINE
Pesquisa : D03.633.100.810.835.322.186 [Categoria DeCS]
Referências encontradas : 11802 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1181 ir para página                         

  1 / 11802 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28841526
[Au] Autor:Rostamian R; Behnejad H
[Ad] Endereço:Department of Physical Chemistry, School of Chemistry, University College of Science, University of Tehran, Tehran 14155, Iran.
[Ti] Título:A comprehensive adsorption study and modeling of antibiotics as a pharmaceutical waste by graphene oxide nanosheets.
[So] Source:Ecotoxicol Environ Saf;147:117-123, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The adsorption behavior of tetracycline (TCN), doxycycline (DCN) as the most common antibiotics in veterinary and ciprofloxacin (CPN) onto graphene oxide nanosheets (GOS) in aqueous solution was evaluated. The four factors influencing the adsorption of antibiotics (initial concentration, pH, temperature and contact time) were studied. The results showed that initial pH ∼ 6 to 7 and contact time ∼ 100 - 200min are optimum for each drug. The monolayer adsorption capacity was reduced with the increasing temperature from 25°C to 45°C. Non-linear regressions were carried out in order to define the best fit model for every system. To do this, eight error functions were applied to predict the optimum model. Among various models, Hill and Toth isotherm models represented the equilibrium adsorption data of antibiotics while the kinetic data were well fitted by pseudo second-order (PSO) kinetic model (DCN and TCN) and Elovich (CPN) models. The maximum adsorption capacity (q ) is found to be in the following order: CPN >> DCN > TCN, obtained from sips equation at the same temperature. The GOS shows highest adsorption capacity towards CPN up to 173.4mgg . The study showed that GOS can be removed more efficiently from water solution.
[Mh] Termos MeSH primário: Antibacterianos/análise
Grafite/química
Modelos Teóricos
Nanoestruturas/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Antibacterianos/química
Ciprofloxacino/análise
Ciprofloxacino/química
Doxiciclina/análise
Doxiciclina/química
Concentração de Íons de Hidrogênio
Cinética
Óxidos/química
Temperatura Ambiente
Tetraciclina/análise
Tetraciclina/química
Termodinâmica
Drogas Veterinárias/análise
Drogas Veterinárias/química
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oxides); 0 (Veterinary Drugs); 0 (Water Pollutants, Chemical); 5E8K9I0O4U (Ciprofloxacin); 7782-42-5 (Graphite); F8VB5M810T (Tetracycline); N12000U13O (Doxycycline)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


  2 / 11802 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29458676
[Au] Autor:Gorla MC; Cassiolato AP; Pinhata JMW; de Moraes C; Corso A; Gagetti P; Lemos AP
[Ad] Endereço:1​Bacteriology Department, Adolfo Lutz Institute, Av. Dr. Arnaldo 351, São Paulo, CEP 01246-902, SP, Brazil.
[Ti] Título:Emergence of resistance to ciprofloxacin in Neisseria meningitidis in Brazil.
[So] Source:J Med Microbiol;67(3):286-288, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To prevent secondary invasive meningococcal disease (IMD) cases and outbreaks, antimicrobial prophylaxis of high-risk contacts is indicated. This study reports two ciprofloxacin-resistant Neisseria meningitidis strains in Brazil. The 3523 N. meningitidis isolates collected throughout Brazil from 2009 to 2016 were evaluated for antimicrobial resistance. Meningococcal isolates showing minimal inhibitory concentrations, MICs≥0.125µg ml to ciprofloxacin, were analysed to determine the presence of mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC genes. Two ciprofloxacin-resistant N. meningitidis isolates were found, both presenting a single mutation in the quinolone resistance-determining region of the gyrA gene. These results confirmed that ciprofloxacin is still a first-line drug for chemoprophylaxis. However, we highlight the importance of continued surveillance to monitor the trends of N. meningitidis susceptibility profiles to the antimicrobials recommended for chemoprophylaxis and IMD treatment.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Ciprofloxacino/farmacologia
Farmacorresistência Bacteriana/genética
Infecções Meningocócicas/microbiologia
Neisseria meningitidis/efeitos dos fármacos
Neisseria meningitidis/genética
[Mh] Termos MeSH secundário: Brasil/epidemiologia
DNA Girase/genética
DNA Topoisomerase IV/genética
Fluoroquinolonas/farmacologia
Seres Humanos
Infecções Meningocócicas/epidemiologia
Testes de Sensibilidade Microbiana
Tipagem de Sequências Multilocus
Mutação
Neisseria gonorrhoeae/isolamento & purificação
Quinolonas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); 0 (Quinolones); 5E8K9I0O4U (Ciprofloxacin); EC 5.99.1.- (DNA Topoisomerase IV); EC 5.99.1.3 (DNA Gyrase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000685


  3 / 11802 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28466356
[Au] Autor:Jensen RG; Johansen HK; Bjarnsholt T; Eickhardt-Sørensen SR; Homøe P
[Ad] Endereço:Department of Otolaryngology, Head and Neck Surgery, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark. ramon@dadlnet.dk.
[Ti] Título:Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link?
[So] Source:Eur Arch Otorhinolaryngol;274(7):2741-2747, 2017 Jul.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Dispersal of bacteria from a biofilm in the middle ear, serving as a bacterial reservoir, could explain the recurrent and chronic nature of chronic suppurative otitis media (CSOM). The objective of this study is to investigate if the same strains of bacteria could be detected in repeated episodes of otorrhea in CSOM. In a prospective case series at a primary healthcare clinic in Nuuk, Greenland, patients with more than 14 days of otorrhea were included consecutively. Samples for culturing and biofilm analysis were taken at enrollment and at any subsequent episode with otorrhea. Participants were treated with daily saline irrigation and Ciprofloxacin eardrops for 7-14 days. Biofilm was identified in otorrhea in 81% (17/21) of participants at enrollment. Multispecies infections dominated with Non-typeable Haemophilus Influenzae (NTHI), Staphyloccocus aureus, and anaerobes being the most frequent pathogens. After the initial treatment, 19 (90%) had dry ears. Median observation period was 140 days (range 14-280) where 13 participants had one or more recurrences. Median time to first recurrence was 60 days (range 14-197). Among the 13 with recurrence, three individuals had the same genotype of bacteria at a subsequent episode. Another two had the same phenotype (NTHI). The remaining eight had new multispecies infections. We confirmed a high rate of biofilm in CSOM. However, the clinical implication might be of minor importance when treating with irrigation and antibiotic eardrops, as recurrent episodes of otorrhea were dominated by new pathogens in each episode.
[Mh] Termos MeSH primário: Biofilmes
Orelha Média/microbiologia
Otite Média Supurativa/microbiologia
[Mh] Termos MeSH secundário: Administração Tópica
Adolescente
Adulto
Antibacterianos/uso terapêutico
Criança
Pré-Escolar
Doença Crônica
Ciprofloxacino/uso terapêutico
Terapia Combinada
Feminino
Groenlândia
Seres Humanos
Lactente
Masculino
Otite Média Supurativa/tratamento farmacológico
Otite Média Supurativa/terapia
Estudos Prospectivos
Recidiva
Irrigação Terapêutica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-017-4586-8


  4 / 11802 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29297622
[Au] Autor:Tutelyan AV; Pisarev VM; Minaeva NZ; Gaponov AM; Gracheva AN; Solopova GG
[Ti] Título:Generation of Antibiotic Tolerant Bacterial Persisters in Immunocompromized Patients with Hematologic and Malignant Diseases: A New Problem of Health-Care Associated Infections.
[So] Source:Vestn Ross Akad Med Nauk;71(3):183-9, 2016.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Background: Antibiotic tolerance (AT) represents one of the causes of the phenomenon of antibiotic resistance that allows escape of non-replicating metabolically inert microorganisms (persisters) from any antibiotics attack because molecular targets of antibiotics are lacking thereby creating the potential for chronic infections. Aims: Determine the heterogeneity of the strains of opportunistic pathogens E. coli and P. aeruginosa isolates from children with hematologic malignancies containing bacterial persisters that cause the AT phenomenon. Methods: Children with hematological malignancies were divided into 2 groups according to the intensity of antibiotic treatment of infectious complications. Ciprofloxacin-induced persisters were quantitatively determined in the biological materials obtained from sick children. Results: Within the clinical isolates of E. coli and P. aeruginosa, about a third of the strains belong to high-persisting. The numbers of persistent forms of bacteria did not correlate with a minimal inhibitory concentration values ciprofloxacin (r=0.148, n=25, p>0.05). Interestingly, higher level of formation of persistent E. coli and P. aeruginosa, is associated with higher frequencies of infection attacks, massive antibiotic use and unfavorable course of the disease in children. Conclusions: Therefore, detecting the persistent forms of bacterial pathogens including those associated with the health-care associated infection, specifically, in immunocompromised patients, should be included into the contemporary algorithms of microbiological observation and monitoring of patients and intrahospital environment.
[Mh] Termos MeSH primário: Ciprofloxacino/uso terapêutico
Tolerância a Medicamentos
Escherichia coli
Neoplasias Hematológicas
Infecções Oportunistas
Pseudomonas aeruginosa
[Mh] Termos MeSH secundário: Adolescente
Antibacterianos/uso terapêutico
Criança
Infecção Hospitalar/prevenção & controle
Resistência Microbiana a Medicamentos/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Escherichia coli/isolamento & purificação
Feminino
Neoplasias Hematológicas/complicações
Neoplasias Hematológicas/microbiologia
Seres Humanos
Hospedeiro Imunocomprometido/efeitos dos fármacos
Masculino
Testes de Sensibilidade Microbiana/métodos
Infecções Oportunistas/diagnóstico
Infecções Oportunistas/tratamento farmacológico
Infecções Oportunistas/etiologia
Pseudomonas aeruginosa/efeitos dos fármacos
Pseudomonas aeruginosa/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE


  5 / 11802 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29426303
[Au] Autor:Singh S; Shrivastav A; Agarwal M; Gandhi A; Mayor R; Paul L
[Ad] Endereço:Vitreoretina services, Dr. Shroff's Charity Eye Hospital, 5027, Kedarnath Road, Daryaganj, New Delhi, 110002, India. drshalini15@gmail.com.
[Ti] Título:A rare case of scleral buckle infection with Curvularia species.
[So] Source:BMC Ophthalmol;18(1):35, 2018 Feb 09.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Scleral buckling is an established modality of treating retinal detachment. Being an external implant the buckle may be prone to infections. We report such a case with a delayed presentation and a rare etiology. CASE PRESENTATION: A 45 year old male presented with redness, foreign body sensation and discharge for one month in his right eye. The patient had undergone a retinal detachment surgery elsewhere 14 years back without any visual gain. Right eye demonstrated no perception of light and the best corrected visual acuity in the left eye was 6/6, N6. On downgaze an exposed and anteriorly displaced scleral buckle was identified with black deposits and mucopurulent material overlying the buckle. Scleral buckle removal was done. On microbiological examination Curvularia species was identified. Successful treatment with antifungals was done. CONCLUSIONS: Scleral buckle infection with dematiaceous fungi is a rare occurrence. To the best of our knowledge this is the first case report describing a buckle infection caused by the curvularia species.
[Mh] Termos MeSH primário: Ascomicetos/isolamento & purificação
Infecções Oculares Fúngicas/microbiologia
Micoses/microbiologia
Infecções Relacionadas à Prótese/microbiologia
Recurvamento da Esclera/efeitos adversos
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Antifúngicos/uso terapêutico
Ciprofloxacino/uso terapêutico
Quimioterapia Combinada
Infecções Oculares Fúngicas/diagnóstico
Infecções Oculares Fúngicas/tratamento farmacológico
Fluconazol/uso terapêutico
Seres Humanos
Masculino
Meia-Idade
Micoses/diagnóstico
Micoses/tratamento farmacológico
Infecções Relacionadas à Prótese/diagnóstico
Infecções Relacionadas à Prótese/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 5E8K9I0O4U (Ciprofloxacin); 8VZV102JFY (Fluconazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180211
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0695-4


  6 / 11802 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29240328
[Au] Autor:Turner B; Pati J; Nargund V; Claxton A; Longstaff V; Sarkar S; Green J
[Ti] Título:Ciprofloxacin Resistance: A Review of Patients in East London Undergoing Prostate Biopsy.
[So] Source:Urol Nurs;36(4):173-82, 2016 Jul-Aug.
[Is] ISSN:1053-816X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transrectal ultrasound guided biopsy of the prostate remains the gold standard investigation to diagnose prostate cancer. Although post-biopsy complications are relatively rare, the risk of sepsis associated with the procedure means that prophylactic antibiotics are paramount. The most widely used antibiotic regimen includes a quinolone, such as ciprofloxacin. Resistance to quinolone antibiotics is rising. In this small pilot study, the incidence of quinolone resistance was 18% in our population of patients attending the prostate biopsy clinic.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Ciprofloxacino/uso terapêutico
Farmacorresistência Bacteriana
Infecções por Escherichia coli/prevenção & controle
Escherichia coli/fisiologia
Próstata/patologia
Reto/microbiologia
[Mh] Termos MeSH secundário: Antibioticoprofilaxia/métodos
Escherichia coli/isolamento & purificação
Seres Humanos
Biópsia Guiada por Imagem
Masculino
Projetos Piloto
Complicações Pós-Operatórias/prevenção & controle
Sepse/prevenção & controle
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  7 / 11802 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28958725
[Au] Autor:Gomes MP; de Brito JCM; Carvalho Carneiro MML; Ribeiro da Cunha MR; Garcia QS; Figueredo CC
[Ad] Endereço:Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Botânica, Avenida Antônio Carlos, 6627, Pampulha, Caixa Postal 486, 31270-970, Belo Horizonte, Minas Gerais, Brazil; Universidade Federal do Paraná, Setor de Ciências Biológicas, Departamento de Botânica, Avenida
[Ti] Título:Responses of the nitrogen-fixing aquatic fern Azolla to water contaminated with ciprofloxacin: Impacts on biofertilization.
[So] Source:Environ Pollut;232:293-299, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We investigated the ability of the aquatic fern Azolla to take up ciprofloxacin (Cipro), as well as the effects of that antibiotic on the N-fixing process in plants grown in medium deprived (-N) or provided (+N) with nitrogen (N). Azolla was seen to accumulate Cipro at concentrations greater than 160 µg g dry weight when cultivated in 3.05 mg Cipro l , indicating it as a candidate for Cipro recovery from water. Although Cipro was not seen to interfere with the heterocyst/vegetative cell ratios, the antibiotic promoted changes with carbon and nitrogen metabolism in plants. Decreased photosynthesis and nitrogenase activity, and altered plant's amino acid profile, with decreases in cell N concentrations, were observed. The removal of N from the growth medium accentuated the deleterious effects of Cipro, resulting in lower photosynthesis, N-fixation, and assimilation rates, and increased hydrogen peroxide accumulation. Our results shown that Cipro may constrain the use of Azolla as a biofertilizer species due to its interference with nitrogen fixation processes.
[Mh] Termos MeSH primário: Antibacterianos/toxicidade
Ciprofloxacino/toxicidade
Gleiquênias/fisiologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Gleiquênias/crescimento & desenvolvimento
Nitrogênio/metabolismo
Fixação de Nitrogênio
Fotossíntese/efeitos dos fármacos
Testes de Toxicidade
Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 5E8K9I0O4U (Ciprofloxacin); N762921K75 (Nitrogen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE


  8 / 11802 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27771372
[Au] Autor:Peng J; Cao J; Ng FM; Hill J
[Ad] Endereço:Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore. Electronic address: jianhepeng@gmail.com.
[Ti] Título:Pseudomonas aeruginosa develops Ciprofloxacin resistance from low to high level with distinctive proteome changes.
[So] Source:J Proteomics;152:75-87, 2017 01 30.
[Is] ISSN:1876-7737
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pseudomonas aeruginosa infection is difficult to treat because of its drug resistance, but how it develops drug resistance remains largely unknown. In this study we investigated Ciprofloxacin resistance development in P. aeruginosa. Different Ciprofloxacin concentrations selected different low level resistant mutants, and high level resistant mutants emerged from low level resistant mutants if stressed further by Ciprofloxacin. A deep quantitative proteomic study of the Ciprofloxacin resistant mutants uncovered the cellular pathways that supported such resistances. The two low level resistant mutants had different molecular mechanisms. One was mainly due to switching to anaerobic respiration and overexpression of catalase and peroxidase, and the other was probably due to iron and polyamine uptake and DNA repair. High level of resistance involved the mexCD-oprJ efflux pump and the downregulation of PQS quorum sensing. Other pathways might also have contributed to high level resistance, like the arginine deiminase pathway, catalase, peroxidase, protein degradation and DNA repair. The intracellular Ciprofloxacin concentration assay indicated that only the mexCD-oprJ overexpressed mutants had low drug accumulation. This study provided a comprehensive overview of the proteomic landscape in the evolution of Ciprofloxacin resistance in P. aeruginosa, and might have implications in diagnosis and treatment of Ciprofloxacin resistant P. aeruginosa. Data are available via ProteomeXchange with identifier PXD004560. BIOLOGICAL SIGNIFICANCE: Pseudomonas aeruginosa infection is difficult to treat because of its drug resistance, but how it develops drug resistance remains largely unknown. In this study we investigated Ciprofloxacin resistance development in P. aeruginosa. We found that Ciprofloxacin resistance developed from low to high level. Two different low levels resistant molecular mechanisms were discovered from different mutants selected by different Ciprofloxacin concentrations, one was mainly due to switching to anaerobic respiration and overexpression of catalase and peroxidase, the other was probably due to iron, polyamine, and DNA repair. High level of Ciprofloxacin resistance all involved the efflux pump, mexCD-oprJ, and the downregulation of quorum sensing. The findings of this study provided insights into the evolution of Ciprofloxacin resistance in P. aeruginosa and should have implications in diagnosis and treatment of Ciprofloxacin resistant P. aeruginosa.
[Mh] Termos MeSH primário: Ciprofloxacino/farmacologia
Regulação Bacteriana da Expressão Gênica
Proteoma/metabolismo
Pseudomonas aeruginosa/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anaerobiose
Antibacterianos/farmacologia
Catalase/metabolismo
Reparo do DNA/genética
Farmacorresistência Bacteriana
Ferro/metabolismo
Proteínas de Membrana/fisiologia
Proteínas de Membrana Transportadoras/fisiologia
Peroxidase/metabolismo
Poliaminas/metabolismo
Pseudomonas aeruginosa/genética
Percepção de Quorum
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Membrane Proteins); 0 (Membrane Transport Proteins); 0 (MexC protein, Pseudomonas aeruginosa); 0 (MexD protein, Pseudomonas aeruginosa); 0 (OprJ protein, Pseudomonas aeruginosa); 0 (Polyamines); 0 (Proteome); 5E8K9I0O4U (Ciprofloxacin); E1UOL152H7 (Iron); EC 1.11.1.6 (Catalase); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  9 / 11802 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29185900
[Au] Autor:Shahabadi N; Asadian AA; Mahdavi M
[Ad] Endereço:a Inorganic Chemistry Department, Faculty of Chemistry , Razi University , Kermanshah , Iran.
[Ti] Título:Intercalation of a Zn(II) complex containing ciprofloxacin drug between DNA base pairs.
[So] Source:Nucleosides Nucleotides Nucleic Acids;36(11):676-689, 2017 Nov 02.
[Is] ISSN:1532-2335
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, an attempt has been made to study the interaction of a Zn(II) complex containing an antibiotic drug, ciprofloxacin, with calf thymus DNA using spectroscopic methods. It was found that Zn(II) complex could bind with DNA via intercalation mode as evidenced by: hyperchromism in UV-Vis spectrum; these spectral characteristics suggest that the Zn(II) complex interacts with DNA most likely through a mode that involves a stacking interaction between the aromatic chromophore and the base pairs of DNA. DNA binding constant (K = 1.4 × 10 M ) from spectrophotometric studies of the interaction of Zn(II) complex with DNA is comparable to those of some DNA intercalative polypyridyl Ru(II) complexes 1.0 -4.8 × 10 M . CD study showed stabilization of the right-handed B form of DNA in the presence of Zn(II) complex as observed for the classical intercalator methylene blue. Thermodynamic parameters (ΔH < 0 and ΔS < 0) indicated that hydrogen bond and Van der Waals play main roles in this binding prose. Competitive fluorimetric studies with methylene blue (MB) dye have shown that Zn(II) complex exhibits the ability of this complex to displace with DNA-MB, indicating that it binds to DNA in strong competition with MB for the intercalation.
[Mh] Termos MeSH primário: Pareamento de Bases
Ciprofloxacino/química
Complexos de Coordenação/química
Complexos de Coordenação/farmacologia
DNA/química
Zinco/química
[Mh] Termos MeSH secundário: Animais
Ligação Competitiva
Bovinos
Complexos de Coordenação/metabolismo
DNA/metabolismo
Substâncias Intercalantes/química
Substâncias Intercalantes/metabolismo
Substâncias Intercalantes/farmacologia
Azul de Metileno/metabolismo
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Intercalating Agents); 5E8K9I0O4U (Ciprofloxacin); 9007-49-2 (DNA); 91080-16-9 (calf thymus DNA); J41CSQ7QDS (Zinc); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1080/15257770.2017.1388394


  10 / 11802 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28458435
[Au] Autor:Foti C; Romita P; Zanframundo G; Mastrolonardo M; Angelini G; Calogiuri G; Nettis E; Bonamonte D
[Ad] Endereço:Dermatological Clinic, Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.
[Ti] Título:Ciprofloxacin induced acute generallised exanthematous pustulosis.
[So] Source:Indian J Pharmacol;49(1):119-120, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Acute generalized exanthematous pustulosis (AGEP) is an uncommon and self-limiting skin rash commonly caused by drugs and is characterized by the acute onset of fever, pustulosis, and neutrophilia from 4 to 10 days after the drug intake. We describe a case of AGEP in a 61-year-old woman that was hospitalized for the acute onset of fever, erythroderma, and pustulosis. Clinical history revealed that she had been treating a bacterial inguinal intertrigo for 4 days with ciprofloxacin 500 mg tablets twice daily and desloratadine 5 mg tablet once daily. To the best of our knowledge, this is the third reported case of AGEP caused by ciprofloxacin, supporting two other previous reports.
[Mh] Termos MeSH primário: Pustulose Exantematosa Aguda Generalizada/etiologia
Antibacterianos/efeitos adversos
Ciprofloxacino/efeitos adversos
Erupção por Droga/etiologia
[Mh] Termos MeSH secundário: Pustulose Exantematosa Aguda Generalizada/patologia
Antibacterianos/administração & dosagem
Ciprofloxacino/administração & dosagem
Erupção por Droga/patologia
Feminino
Febre/etiologia
Seres Humanos
Intertrigo/tratamento farmacológico
Loratadina/administração & dosagem
Loratadina/análogos & derivados
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin); 7AJO3BO7QN (Loratadine); FVF865388R (desloratadine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201014



página 1 de 1181 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde