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[PMID]:29061803
[Au] Autor:Nishi K; Kato M; Sakurai S; Matsumoto A; Iwase Y; Yumita N
[Ad] Endereço:Laboratory of Drug Metabolism and Pharmacotherapeutics, Department of Clinical Pharmacy, Yokohama University of Pharmacy, Kanagawa, Japan k.nishi@hamayaku.ac.jp.
[Ti] Título:Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation.
[So] Source:Anticancer Res;37(11):6211-6214, 2017 11.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Pancreatic cancer is one of the deadliest human cancers. In the current study, we investigated the possibility of a new treatment strategy using a combination of the new fluoroquinolone, enoxacin, and mild ultraviolet A (UVA) irradiation. Enoxacin with UVA irradiation increased the number of annexin V-positive (apoptotic) pancreatic cancer cells in time- and concentration-dependent manners, whereas alone neither had these effects. In addition, enoxacin with UVA irradiation induced cleavage of poly (ADP-ribose) polymerase in AsPC1 human pancreatic cancer cells. Moreover, the singlet oxygen scavengers, histidine and sodium azide, and the hydroxyl radical scavenger, mannitol, significantly suppressed apoptosis induced by enoxacin and UVA irradiation, respectively. These results suggest that UVA irradiation activates enoxacin, after which activated enoxacin induces apoptosis of AsPC1 cells through generation of reactive oxygen species. Therefore, the combination of enoxacin with mild UVA irradiation may be a useful method for treating pancreatic cancer.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Apoptose/efeitos da radiação
Enoxacino/farmacologia
Neoplasias Pancreáticas/patologia
Espécies Reativas de Oxigênio/metabolismo
Raios Ultravioleta
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Proliferação Celular/efeitos da radiação
Seres Humanos
Neoplasias Pancreáticas/tratamento farmacológico
Neoplasias Pancreáticas/metabolismo
Neoplasias Pancreáticas/radioterapia
Poli(ADP-Ribose) Polimerases/metabolismo
Inibidores da Topoisomerase II/farmacologia
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 0 (Topoisomerase II Inhibitors); 325OGW249P (Enoxacin); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE


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[PMID]:28973015
[Au] Autor:Valianatos G; Valcikova B; Growkova K; Verlande A; Mlcochova J; Radova L; Stetkova M; Vyhnakova M; Slaby O; Uldrijan S
[Ad] Endereço:Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
[Ti] Título:A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein.
[So] Source:PLoS One;12(10):e0185801, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:MdmX overexpression contributes to the development of cancer by inhibiting tumor suppressor p53. A switch in the alternative splicing of MdmX transcript, leading to the inclusion of exon 6, has been identified as the primary mechanism responsible for increased MdmX protein levels in human cancers, including melanoma. However, there are no approved drugs, which could translate these new findings into clinical applications. We analyzed the anti-melanoma activity of enoxacin, a fluoroquinolone antibiotic inhibiting the growth of some human cancers in vitro and in vivo by promoting miRNA maturation. We found that enoxacin inhibited the growth and viability of human melanoma cell lines much stronger than a structurally related fluoroquinolone ofloxacin, which only weakly modulates miRNA processing. A microarray analysis identified a set of miRNAs significantly dysregulated in enoxacin-treated A375 melanoma cells. They had the potential to target multiple signaling pathways required for cancer cell growth, among them the RNA splicing. Recent studies showed that interfering with cellular splicing machinery can result in MdmX downregulation in cancer cells. We, therefore, hypothesized that enoxacin could, by modulating miRNAs targeting splicing machinery, activate p53 in melanoma cells overexpressing MdmX. We found that enoxacin and ciprofloxacin, a related fluoroquinolone capable of promoting microRNA processing, but not ofloxacin, strongly activated wild type p53-dependent transcription in A375 melanoma without causing significant DNA damage. On the molecular level, the drugs promoted MdmX exon 6 skipping, leading to a dose-dependent downregulation of MdmX. Not only in melanoma, but also in MCF7 breast carcinoma and A2780 ovarian carcinoma cells overexpressing MdmX. Together, our results suggest that some clinically approved fluoroquinolones could potentially be repurposed as activators of p53 tumor suppressor in cancers overexpressing MdmX oncoprotein and that p53 activation might contribute to the previously reported activity of enoxacin towards human cancer cells.
[Mh] Termos MeSH primário: Processamento Alternativo/efeitos dos fármacos
Enoxacino/farmacologia
Proteínas Proto-Oncogênicas c-mdm2/genética
Transdução de Sinais/efeitos dos fármacos
Proteína Supressora de Tumor p53/genética
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Neoplasias da Mama/genética
Neoplasias da Mama/metabolismo
Neoplasias da Mama/patologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Dano ao DNA/efeitos dos fármacos
Regulação para Baixo/efeitos dos fármacos
Feminino
Seres Humanos
Melanoma/genética
Melanoma/metabolismo
Melanoma/patologia
Ofloxacino/farmacologia
Neoplasias Ovarianas/genética
Neoplasias Ovarianas/metabolismo
Neoplasias Ovarianas/patologia
Proteínas Proto-Oncogênicas c-mdm2/metabolismo
Proteína Supressora de Tumor p53/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tumor Suppressor Protein p53); 325OGW249P (Enoxacin); A4P49JAZ9H (Ofloxacin); EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185801


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[PMID]:28756357
[Au] Autor:Van Toi P; Pouplin T; Tho NDK; Phuong PN; Chau TTH; Thuong Thuong NT; Heemskerk D; Hien TT; Thwaites GE
[Ad] Endereço:Oxford University Clinical Research Unit, Wellcome Trust Major Oversea Programme, Ho Chi Minh City- In Partnership with Hospital for Tropical Diseases Ho Chi Minh City, Viet Nam. Electronic address: toipv@oucru.org.
[Ti] Título:High-performance liquid chromatography with time-programmed fluorescence detection for the quantification of Levofloxacin in human plasma and cerebrospinal fluid in adults with tuberculous meningitis.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1061-1062:256-262, 2017 Sep 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An accurate and reliable high-performance liquid chromatography with time-programmed fluorescence detection was developed and validated to measure levofloxacin in human plasma and cerebrospinal fluid (CSF). After solid phase extraction process using Evolute ABN 96 fixed well plate; levofloxacin and internal standard-enoxacin were separated using a mobile phase consisting of phosphate buffer 10mM with 0.025% triethylamine pH 3.0 - acetonitrile (88:12, v/v) on a Purosphere RP-8e column (5µm, 125×4.0mm) at a flow rate of 1.2mL/min at 35°C. The excitation/emission wavelengths were set to 269/400nm and 294/500nm, for enoxacin and levofloxacin, respectively. The method was linear over the concentration range of 0.02 to 20.0µg/mL with a limit of detection of 0.01µg/mL. The relative standard deviation of intra-assay and inter-assay precision for levofloxacin at four quality controls concentrations (0.02, 0.06, 3.0 and 15.0µg/mL) were less than 7% and the accuracies ranged from 96.75% to 101.9% in plasma, and from 93.00% to 98.67% in CSF. The validated method was successfully applied to quantify levofloxacin in a considerable quantity of plasma (826) and CSF (477) samples collected from 232 tuberculous meningitis patients, and the preliminary intensive pharmacokinetics analysis from 14 tuberculous meningitis patients in Vietnam is described in this paper.
[Mh] Termos MeSH primário: Antibacterianos/sangue
Antibacterianos/líquido cefalorraquidiano
Cromatografia Líquida de Alta Pressão/métodos
Levofloxacino/sangue
Levofloxacino/líquido cefalorraquidiano
Tuberculose Meníngea/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/farmacocinética
Estabilidade de Medicamentos
Enoxacino
Seres Humanos
Levofloxacino/farmacocinética
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
Extração em Fase Sólida
Espectrometria de Fluorescência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 325OGW249P (Enoxacin); 6GNT3Y5LMF (Levofloxacin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170731
[St] Status:MEDLINE


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[PMID]:28215473
[Au] Autor:Gao M; Igata H; Takeuchi A; Sato K; Ikegaya Y
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; iPS-non Clinical Experiments for Nervous System (iNCENS) Project, Japan.
[Ti] Título:Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds.
[So] Source:J Pharmacol Sci;133(2):70-78, 2017 Feb.
[Is] ISSN:1347-8648
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Various biological factors have been implicated in convulsive seizures, involving side effects of drugs. For the preclinical safety assessment of drug development, it is difficult to predict seizure-inducing side effects. Here, we introduced a machine learning-based in vitro system designed to detect seizure-inducing side effects. We recorded local field potentials from the CA1 alveus in acute mouse neocortico-hippocampal slices, while 14 drugs were bath-perfused at 5 different concentrations each. For each experimental condition, we collected seizure-like neuronal activity and merged their waveforms as one graphic image, which was further converted into a feature vector using Caffe, an open framework for deep learning. In the space of the first two principal components, the support vector machine completely separated the vectors (i.e., doses of individual drugs) that induced seizure-like events and identified diphenhydramine, enoxacin, strychnine and theophylline as "seizure-inducing" drugs, which indeed were reported to induce seizures in clinical situations. Thus, this artificial intelligence-based classification may provide a new platform to detect the seizure-inducing side effects of preclinical drugs.
[Mh] Termos MeSH primário: Convulsões/induzido quimicamente
Máquina de Vetores de Suporte
[Mh] Termos MeSH secundário: Animais
Região CA1 Hipocampal/efeitos dos fármacos
Difenidramina/efeitos adversos
Enoxacino/efeitos adversos
Técnicas In Vitro
Masculino
Camundongos
Camundongos Endogâmicos ICR
Estricnina/efeitos adversos
Teofilina/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
325OGW249P (Enoxacin); 8GTS82S83M (Diphenhydramine); C137DTR5RG (Theophylline); H9Y79VD43J (Strychnine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:27799220
[Au] Autor:Nie B; Long T; Ao H; Zhou J; Tang T; Yue B
[Ad] Endereço:Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
[Ti] Título:Covalent Immobilization of Enoxacin onto Titanium Implant Surfaces for Inhibiting Multiple Bacterial Species Infection and In Vivo Methicillin-Resistant Staphylococcus aureus Infection Prophylaxis.
[So] Source:Antimicrob Agents Chemother;61(1), 2017 Jan.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Infection is one of the most important causes of titanium implant failure in vivo A developing prophylactic method involves the immobilization of antibiotics, especially vancomycin, onto the surface of the titanium implant. However, these methods have a limited effect in curbing multiple bacterial infections due to antibiotic specificity. In the current study, enoxacin was covalently bound to an amine-functionalized Ti surface by use of a polyethylene glycol (PEG) spacer, and the bactericidal effectiveness was investigated in vitro and in vivo The titanium surface was amine functionalized with 3-aminopropyltriethoxysilane (APTES), through which PEG spacer molecules were covalently immobilized onto the titanium, and then the enoxacin was covalently bound to the PEG, which was confirmed by X-ray photoelectron spectrometry (XPS). A spread plate assay, confocal laser scanning microscopy (CLSM), and scanning electron microscopy (SEM) were used to characterize the antimicrobial activity. For the in vivo study, Ti implants were inoculated with methicillin-resistant Staphylococcus aureus (MRSA) and implanted into the femoral medullary cavity of rats. The degree of infection was assessed by radiography, micro-computed tomography, and determination of the counts of adherent bacteria 3 weeks after surgery. Our data demonstrate that the enoxacin-modified PEGylated Ti surface effectively prevented bacterial colonization without compromising cell viability, adhesion, or proliferation in vitro Furthermore, it prevented MRSA infection of the Ti implants in vivo Taken together, our results demonstrate that the use of enoxacin-modified Ti is a potential approach to the alleviation of infections of Ti implants by multiple bacterial species.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Enoxacino/farmacologia
Polietilenoglicóis/química
Infecções Estafilocócicas/prevenção & controle
Titânio/química
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Interface Osso-Implante
Enoxacino/química
Feminino
Fêmur/efeitos dos fármacos
Fêmur/microbiologia
Fêmur/cirurgia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/crescimento & desenvolvimento
Testes de Sensibilidade Microbiana
Propilaminas/química
Próteses e Implantes/microbiologia
Ratos
Ratos Sprague-Dawley
Silanos/química
Infecções Estafilocócicas/microbiologia
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Propylamines); 0 (Silanes); 30IQX730WE (Polyethylene Glycols); 325OGW249P (Enoxacin); D1JT611TNE (Titanium); L8S6UBW552 (amino-propyl-triethoxysilane)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE


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[PMID]:27998162
[Au] Autor:Ullah O; Khan A; Ambreen A; Ahmad I; Akhtar T; Gandapor AJ; Khan AM
[Ad] Endereço:Senior Research Officer, Pakistan Health Research Council, Research Centre, Khyber Medical College Peshawar, Pakistan.
[Ti] Título:Antibiotic Sensitivity pattern of Bacterial Isolates of Neonatal Septicemia in Peshawar, Pakistan.
[So] Source:Arch Iran Med;19(12):866-869, 2016 Dec.
[Is] ISSN:1735-3947
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Septicemia plays an important role in neonatal morbidity and mortality, especially in developing countries. OBJECTIVE: To investigate the bacterial pathogens causing neonatal sepsis and their antibiotic susceptibility profile. METHODOLOGY: A total of 2,685 neonates aged 0-28 days were included in the study. Blood from each neonate was cultured and isolates were identified using standard biochemical tests. Antibiotic sensitivity pattern was analyzed using modified Kirby-Bauer disc diffusion method. RESULTS: Blood culture positivity was observed in 1,534 (57.1%) samples. Most of the cases (1089 counts - 71%) were of early onset sepsis while 445 (29%) were of late onset sepsis. The incidence of sepsis was higher in males 856 (55.8%) than females 678 (44.2%) with a 1:2 ratio. Similarly, 58.3% of septicemic patients were neonates with low birth weights. Twelve hundred and six (78.6%) isolates were gram negative while 328 (23.4%) were gram positive bacteria. E. coli was the dominant pathogen seen in 811 (52.8%) followed by Staphylococcus aureus 300 (19.5%), Pseudomonas 199 (13%), Klebsiella 102 (6.7%), Proteus 87 (5.7%), Staphylococcus epidermidis 28(1.8%) and Salmonella in 7 (0.5%) samples. All bacterial isolates showed high sensitivity to Imipenem, Enoxacin, Ofloxacin and Ciprofloxacin while low sensitivity was observed for other antibiotics (n = 16). The Proteus species showed high level of multiple resistances to all antibiotics (5.9%). CONCLUSION: Imipenem, Enoxacin, Ofloxacin and Ciprofloxacin can be used as an effective antibiotic regimen for treatment of bacterial sepsis in neonates.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana Múltipla
Bactérias Gram-Negativas/efeitos dos fármacos
Infecções por Bactérias Gram-Negativas/microbiologia
Sepse Neonatal/microbiologia
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus epidermidis/efeitos dos fármacos
[Mh] Termos MeSH secundário: Ciprofloxacino/farmacologia
Farmacorresistência Bacteriana
Enoxacino/farmacologia
Escherichia coli/efeitos dos fármacos
Escherichia coli/fisiologia
Infecções por Escherichia coli/microbiologia
Feminino
Bactérias Gram-Negativas/fisiologia
Seres Humanos
Imipenem/farmacologia
Recém-Nascido de Baixo Peso
Recém-Nascido
Klebsiella/efeitos dos fármacos
Klebsiella/fisiologia
Infecções por Klebsiella/microbiologia
Masculino
Testes de Sensibilidade Microbiana
Ofloxacino/farmacologia
Paquistão
Proteus/efeitos dos fármacos
Proteus/fisiologia
Infecções por Proteus/microbiologia
Pseudomonas/efeitos dos fármacos
Pseudomonas/fisiologia
Infecções por Pseudomonas/microbiologia
Staphylococcus aureus/fisiologia
Staphylococcus epidermidis/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 325OGW249P (Enoxacin); 5E8K9I0O4U (Ciprofloxacin); 71OTZ9ZE0A (Imipenem); A4P49JAZ9H (Ofloxacin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:0161912/AIM.009


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[PMID]:27903219
[Au] Autor:Mahmood I
[Ad] Endereço:Division of Hematology Clinical Review, Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993-0002, USA.
[Ti] Título:Prediction of Plasma Concentration-time Profiles of Drugs in Humans from Animals Following Oral Administration: An Allometric Approach.
[So] Source:Curr Drug Metab;17(10):1006-1013, 2016.
[Is] ISSN:1875-5453
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allometric scaling is regularly used for the prediction of human pharmacokinetic (PK) parameters from animal PK studies. The predicted human PK parameters can also be used for the prediction of plasma concentration-time profiles in humans. OBJECTIVES: The main objective of this work is to predict human concentration-time profiles of drugs (one-compartment model) following oral administration using animal oral pharmacokinetic parameters. METHODS: Six drugs from the literature were chosen that were described by one-compartment model in both humans and animals following oral administration. Pharmacokinetic parameters such as oral clearance, oral volume of distribution of the central compartment, time to reach maximum plasma concentration, absorption rate constant, and half-life in humans were predicted from animals using allometric scaling. These predicted human pharmacokinetic parameters were then used to predict human plasma concentrations-time profiles of drugs. RESULTS: The results of this study indicate that the proposed method can be used to predict human plasma concentrations- time profiles of drugs with reasonable accuracy (≤50% prediction error). CONCLUSIONS: Given the complexity in the pharmacokinetics of oral drugs there remains some uncertainty in this entire exercise. One can minimize the prediction error by experience in allometric scaling, scientific judgment, and unconventional or innovative thinking.
[Mh] Termos MeSH primário: Enoxacino
Fluoroquinolonas
Linezolida
Modelos Biológicos
Monossacarídeos
Citrato de Sildenafila
Triazóis
Cloridrato de Venlafaxina
[Mh] Termos MeSH secundário: Administração Oral
Animais
Peso Corporal
Enoxacino/administração & dosagem
Enoxacino/sangue
Enoxacino/farmacocinética
Fluoroquinolonas/administração & dosagem
Fluoroquinolonas/sangue
Fluoroquinolonas/farmacocinética
Meia-Vida
Seres Humanos
Linezolida/administração & dosagem
Linezolida/sangue
Linezolida/farmacocinética
Taxa de Depuração Metabólica
Monossacarídeos/administração & dosagem
Monossacarídeos/sangue
Monossacarídeos/farmacocinética
Citrato de Sildenafila/administração & dosagem
Citrato de Sildenafila/sangue
Citrato de Sildenafila/farmacocinética
Triazóis/administração & dosagem
Triazóis/sangue
Triazóis/farmacocinética
Cloridrato de Venlafaxina/administração & dosagem
Cloridrato de Venlafaxina/sangue
Cloridrato de Venlafaxina/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluoroquinolones); 0 (Monosaccharides); 0 (Triazoles); 0 (levovirin valinate hydrochloride); 325OGW249P (Enoxacin); 7D7RX5A8MO (Venlafaxine Hydrochloride); BW9B0ZE037 (Sildenafil Citrate); ISQ9I6J12J (Linezolid); V72H9867WB (garenoxacin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE
[do] DOI:10.2174/1389200218666161121120223


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[PMID]:26724376
[Au] Autor:Omar MA; Salama A; Elsify A; Rizk MA; Al-Aboody MS; AbouLaila M; El-Sayed SA; Igarashi I
[Ad] Endereço:Department of Parasitology, Faculty of Veterinary Medicine, SouthValley University, Qena 83523, Egypt; Department of Medical Laboratories, College of Science Al-Zulfi, AlMajmaah University, Alzulfi 11932, Riyadh, Saudi Arabia. Electronic address: ma.omar@mu.edu.sa.
[Ti] Título:Evaluation of in vitro inhibitory effect of enoxacin on Babesia and Theileria parasites.
[So] Source:Exp Parasitol;161:62-7, 2016 Feb.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid used mainly in the treatment of urinary tract infections and gonorrhea. Also it has been shown recently that it may have cancer inhibiting effect. The primary antibabesial effect of Enoxacin is due to inhibition of DNA gyrase subunit A, and DNA topoisomerase. In the present study, enoxacin was tested as a potent inhibitor against the in vitro growth of bovine and equine Piroplasms. The in vitro growth of five Babesia species that were tested was significantly inhibited (P < 0.05) by micro molar concentrations of enoxacin (IC50 values = 33.5, 15.2, 7.5 and 23.2 µM for Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi, respectively). Enoxacin IC50 values for Babesia and Theileria parasites were satisfactory as the drug is potent antibacterial drug with minimum side effects. Therefore, enoxacin might be used for treatment of Babesiosis and Theileriosis especially in case of mixed infections with bacterial diseases or incase of animal sensitivity against diminazin toxicity.
[Mh] Termos MeSH primário: Antiprotozoários/farmacologia
Babesia/efeitos dos fármacos
Enoxacino/farmacologia
Theileria/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Babesia/crescimento & desenvolvimento
Babesiose/tratamento farmacológico
Bovinos
Cavalos
Concentração Inibidora 50
Theileria/crescimento & desenvolvimento
Theileriose/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antiprotozoal Agents); 325OGW249P (Enoxacin)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160118
[Lr] Data última revisão:
160118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160103
[St] Status:MEDLINE


  9 / 609 MEDLINE  
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[PMID]:26643651
[Au] Autor:Lu L; Chen C; Zhao D; Sun J; Yang X
[Ad] Endereço:State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun, Jilin 130022, China.
[Ti] Título:Europium Luminescence Used for Logic Gate and Ions Sensing with Enoxacin As the Antenna.
[So] Source:Anal Chem;88(2):1238-45, 2016 Jan 19.
[Is] ISSN:1520-6882
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Luminescent lanthanide ion complexes have received increasing attention because of their unique optical properties. Herein, we discovered that the luminescence of europium(III) (Eu(3+)) could be regulated by Ag(+) and SCN(-) in seconds with enoxacin (ENX) as the antenna. Under given conditions, only the simultaneous introduction of Ag(+) and SCN(-) could remarkably enhance the luminescence intensity of Eu(3+)-ENX complexes. This phenomenon has been exploited to design an "AND" logic gate and specific luminescence turn-on assays for sensitively sensing Ag(+) and SCN(-) for the first time. Furthermore, the addition of S(2-) resulted in efficient luminescence quenching of the Eu(3+)/ENX/Ag(+)/SCN(-) system due to the strong affinity between Ag(+) and S(2-). Thus, a new luminescent sensing platform for S(2-) was established, which exhibited excellent selectivity and high sensitivity. S(2-) could be detected within the concentration range of 100 nM to 12.5 µM with a detection limit of 60 nM. Such sensing system features simplicity, rapidity, and flexibility. Moreover, this proposed Eu(3+)-based luminescent assay could be successfully applied in the real environmental water sample analysis.
[Mh] Termos MeSH primário: Enoxacino/química
Európio/análise
Luminescência
Sulfetos/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Computadores Moleculares
Íons/análise
Lagos
Lógica
Medições Luminescentes
Prata/química
Tiocianatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ions); 0 (Sulfides); 0 (Thiocyanates); 0 (Water Pollutants, Chemical); 325OGW249P (Enoxacin); 3M4G523W1G (Silver); 444W947O8O (Europium)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151209
[St] Status:MEDLINE
[do] DOI:10.1021/acs.analchem.5b03593


  10 / 609 MEDLINE  
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[PMID]:26413803
[Au] Autor:Annabi C; Fourcade F; Soutrel I; Geneste F; Floner D; Bellakhal N; Amrane A
[Ad] Endereço:Institut des Sciences Chimiques de Rennes, Ecole Nationale Supérieure de Chimie de Rennes, Université de Rennes 1, UMR-CNRS 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France; Centre d'Electrochimie de Nanomatériaux et Leurs Applications et de Didactique (CENAD), France; Institut Nat
[Ti] Título:Degradation of enoxacin antibiotic by the electro-Fenton process: Optimization, biodegradability improvement and degradation mechanism.
[So] Source:J Environ Manage;165:96-105, 2016 Jan 01.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aims to investigate the effectiveness of the electro-Fenton process on the removal of a second generation of fluoroquinolone, enoxacin. The electrochemical reactor involved a carbon-felt cathode and a platinum anode. The influence of some experimental parameters, namely the initial enoxacin concentration, the applied current intensity and the Fe(II) amount, was examined. The degradation of the target molecule was accompanied by an increase of the biodegradability, assessed from the BOD5 on COD ratio, which increased from 0 before treatment until 0.5 after 180 min of electrolysis at 50 mg L(-1) initial enoxacin concentration, 0.2 mmol L(-1) Fe(II) concentration and 300 mA applied current intensity. TOC and COD time-courses were also evaluated during electrolysis and reached maximum residual yields of 54% and 43% after 120 min of treatment, respectively. Moreover, a simultaneous generation of inorganic ions (fluorides, ammonium and nitrates) were observed and 3 short chain carboxylic acids (formic, acetic and oxalic acids) were identified and monitored during 180 min of electrolysis. By-products were identified according to UPLC-MS/MS results and a degradation pathway was proposed.
[Mh] Termos MeSH primário: Antibacterianos/química
Enoxacino/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Ácido Acético/química
Antibacterianos/metabolismo
Biodegradação Ambiental
Análise da Demanda Biológica de Oxigênio
Carbono/química
Técnicas Eletroquímicas/instrumentação
Técnicas Eletroquímicas/métodos
Eletrodos
Eletrólise
Enoxacino/metabolismo
Fluoretos/química
Ferro/química
Nitratos
Platina
Espectrometria de Massas em Tandem
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Nitrates); 0 (Water Pollutants, Chemical); 325OGW249P (Enoxacin); 49DFR088MY (Platinum); 7440-44-0 (Carbon); E1UOL152H7 (Iron); Q40Q9N063P (Acetic Acid); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150929
[St] Status:MEDLINE



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