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Pesquisa : D03.633.300.240.127 [Categoria DeCS]
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[PMID]:29024883
[Au] Autor:Sopilniak A; Elkayam R; Rossin AV; Lev O
[Ad] Endereço:Casali Center of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
[Ti] Título:Emerging organic pollutants in the vadose zone of a soil aquifer treatment system: Pore water extraction using positive displacement.
[So] Source:Chemosphere;190:383-392, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trace organic compounds in effluents, water streams and aquifers are amply reported. However, the mobile pool of Emerging Organic Contaminants (EOCs) in the deep parts of the vadose zone is hard to estimate, due to difficulties in extraction of sufficient quantity of pore water. Here, we present a new methodology for depth profiling of EOCs in pore water by Positive Displacement Extraction (PDE): Pore water extraction from unsaturated soil samples is carried out by withdrawal of soil cores by direct-push drilling and infiltrating the core by organics free water. We show that EOC concentrations in the water eluted in the plateau region of the inverse breakthrough curve is equal to their pore water concentrations. The method was previously validated for DOC extraction, and here the scope of the methodology is extended to pore water extraction for organic pollutants analysis. Method characteristics and validation were carried out with atrazine, simazine, carbamazepine, venlafaxine, O-desmethylvenlafaxine and caffeine in the concentration range of several ng to several µg/liter. Validation was carried out by laboratory experiments on three different soils (sandy, sandy-clayey and clayey). Field studies in the vadose zone of a SAT system provided 27 m deep EOC profiles with less than 1.5 m spatial resolution. During the percolation treatment, carbamazepine remained persistent, while the other studied EOCs were attenuated to the extent of 50-99%.The highest degradation rate of all studied EOCs was in the aerobic zone. EOC levels based on PDE and extraction by centrifugation were compared, showing a positive bias for centrifugation.
[Mh] Termos MeSH primário: Água Subterrânea/análise
Poluentes do Solo/análise
Extração em Fase Sólida/métodos
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Atrazina/análise
Carbamazepina/análise
Succinato de Desvenlafaxina/análise
Métodos
Compostos Orgânicos/análise
Simazina
Solo/química
Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organic Chemicals); 0 (Soil); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 33CM23913M (Carbamazepine); QJA9M5H4IM (Atrazine); SG0C34SMY3 (Simazine); ZB22ENF0XR (Desvenlafaxine Succinate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


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[PMID]:29293328
[Au] Autor:Bhalsod GD; Chuang YH; Jeon S; Gui W; Li H; Ryser ET; Guber AK; Zhang W
[Ad] Endereço:Cook County Unit, University of Illinois Extension , Arlington Heights, Illinois 60004, United States.
[Ti] Título:Uptake and Accumulation of Pharmaceuticals in Overhead- and Surface-Irrigated Greenhouse Lettuce.
[So] Source:J Agric Food Chem;66(4):822-830, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the uptake and accumulation of pharmaceuticals in vegetables under typical irrigation practices is critical to risk assessment of crop irrigation with reclaimed water. This study investigated the pharmaceutical residues in greenhouse lettuce under overhead and soil-surface irrigations using pharmaceutical-contaminated water. Compared to soil-surface irrigation, overhead irrigation substantially increased the pharmaceutical residues in lettuce shoots. The increased residue levels persisted even after washing for trimethoprim, monensin sodium, and tylosin, indicating their strong sorption to the shoots. The postwashing concentrations in fresh shoots varied from 0.05 ± 0.04 µg/kg for sulfadiazine to 345 ± 139 µg/kg for carbamazepine. Root concentration factors ranged from 0.04 ± 0.14 for tylosin to 19.2 ± 15.7 for sulfamethoxazole. Translocation factors in surface-irrigated lettuce were low for sulfamethoxalzole, trimethoprim, monensin sodium, and tylosin (0.07-0.15), but high for caffeine (4.28 ± 3.01) and carbamazepine (8.15 ± 2.87). Carbamazepine was persistent in soil and hyperaccumulated in shoots.
[Mh] Termos MeSH primário: Irrigação Agrícola/métodos
Resíduos de Drogas/análise
Alface/metabolismo
Preparações Farmacêuticas/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Carbamazepina/análise
Contaminação de Alimentos
Alface/química
Monensin/análise
Preparações Farmacêuticas/análise
Folhas de Planta/química
Raízes de Plantas/química
Solo/química
Poluentes do Solo/análise
Poluentes do Solo/metabolismo
Sulfametoxazol/análise
Trimetoprima/análise
Tilosina/análise
Verduras
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Soil); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical); 33CM23913M (Carbamazepine); 906O0YJ6ZP (Monensin); AN164J8Y0X (Trimethoprim); JE42381TNV (Sulfamethoxazole); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04355


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[PMID]:28935405
[Au] Autor:Ben Mordechay E; Tarchitzky J; Chen Y; Shenker M; Chefetz B
[Ad] Endereço:Department of Soil and Water Sciences, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 7610001, Israel; The Hebrew University Center of Excellence in Agriculture and Environmental Health, P.O. Box 12, Rehovot 7610001, Israel.
[Ti] Título:Composted biosolids and treated wastewater as sources of pharmaceuticals and personal care products for plant uptake: A case study with carbamazepine.
[So] Source:Environ Pollut;232:164-172, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Irrigation with treated wastewater (TWW) and application of biosolids to arable land expose the agro-environment to pharmaceuticals and personal care products (PPCPs) which can be taken up by crops. In this project, we studied the effect of a carrier medium (e.g., biosolids and TWW) on plant (tomato, wheat and lettuce) uptake, translocation and metabolism of carbamazepine as a model for non-ionic PPCPs. Plant uptake and bioconcentration factors were significantly lower in soils amended with biosolids compared to soils irrigated with TWW. In soils amended with biosolids and irrigated with TWW, the bioavailability of carbamazepine for plant uptake was moderately decreased as compared to plants grown in soils irrigated with TWW alone. While TWW acts as a continuous source of PPCPs, biosolids act both as a source and a sink for these compounds. Moreover, it appears that decomposition of the biosolids in the soil after amendment enhances their adsorptive properties, which in turn reduces the bioavailability of PPCPs in the soil environment. In-plant metabolism of carbamazepine was found to be independent of environmental factors, such as soil type, carrier medium, and absolute amount implemented to the soil, but was controlled by the total amount taken up by the plant.
[Mh] Termos MeSH primário: Carbamazepina/metabolismo
Produtos Agrícolas/metabolismo
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Carbamazepina/análise
Compostagem
Alface/metabolismo
Solo
Poluentes do Solo/metabolismo
Eliminação de Resíduos Líquidos
Águas Residuais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 0 (Waste Water); 33CM23913M (Carbamazepine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE


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[PMID]:29215383
[Au] Autor:Patel N; Viguera AC; Baldessarini RJ
[Ti] Título:Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary.
[So] Source:J Clin Psychopharmacol;38(1):7-10, 2018 Feb.
[Is] ISSN:1533-712X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE/BACKGROUND: High risks of neural tube defects and other teratogenic effects are associated with exposure in early pregnancy to some anticonvulsants, including in women with bipolar disorder. METHODS/PROCEDURES: Based on a semistructured review of recent literature, we summarized findings pertaining to this topic. FINDINGS/RESULTS: Valproate and carbamazepine are commonly used empirically (off-label) for putative long-term mood-stabilizing effects. Both anticonvulsants have high risks of teratogenic effects during pregnancy. Risks of neural tube defects (especially spina bifida) and other major malformations are especially great with valproate and can arise even before pregnancy is diagnosed. Standard supplementation of folic acid during pregnancy can reduce risk of spontaneous spina bifida, but not that associated with valproate or carbamazepine. In contrast, lamotrigine has regulatory approval for long-term use in bipolar disorder and appears not to have teratogenic effects in humans. IMPLICATIONS/CONCLUSIONS: Lack of protective effects against anticonvulsant-associated neural tube defects by folic acid supplements in anticipation of and during pregnancy is not widely recognized. This limitation and high risks of neural tube and other major teratogenic effects, especially of valproate, indicate the need for great caution in the use of valproate and carbamazepine to treat bipolar disorder in women of child-bearing age.
[Mh] Termos MeSH primário: Antimaníacos/efeitos adversos
Ácido Fólico/administração & dosagem
Defeitos do Tubo Neural/prevenção & controle
Disrafismo Espinal/prevenção & controle
[Mh] Termos MeSH secundário: Anticonvulsivantes/administração & dosagem
Anticonvulsivantes/efeitos adversos
Antimaníacos/administração & dosagem
Transtorno Bipolar/tratamento farmacológico
Carbamazepina/administração & dosagem
Carbamazepina/efeitos adversos
Suplementos Nutricionais
Feminino
Seres Humanos
Defeitos do Tubo Neural/induzido quimicamente
Gravidez
Complicações na Gravidez/tratamento farmacológico
Disrafismo Espinal/induzido quimicamente
Triazinas/administração & dosagem
Triazinas/efeitos adversos
Ácido Valproico/administração & dosagem
Ácido Valproico/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Antimanic Agents); 0 (Triazines); 33CM23913M (Carbamazepine); 614OI1Z5WI (Valproic Acid); 935E97BOY8 (Folic Acid); U3H27498KS (lamotrigine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1097/JCP.0000000000000813


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[PMID]:29101853
[Au] Autor:García-Espinoza JD; Mijaylova-Nacheva P; Avilés-Flores M
[Ad] Endereço:National Autonomous University of Mexico (UNAM, Campus IMTA), Paseo Cuauhnahuac 8532, Progreso, Jiutepec, Morelos, 62550, Mexico. Electronic address: iqgarciaespinoza@gmail.com.
[Ti] Título:Electrochemical carbamazepine degradation: Effect of the generated active chlorine, transformation pathways and toxicity.
[So] Source:Chemosphere;192:142-151, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Carbamazepine (CBZ) is a biorecalcitrant pharmaceutical compound frequently detected in wastewater and water bodies which has numerous negative effects on living organisms. In this investigation the effect of electrocatalytically generated active chlorine on CBZ degradation was studied using Nb/BDD or Ti/IrO anodes. Subsequently, a response surface methodology based on a factorial plan and central composite design was carried out to determine the contribution of individual factors and to obtain the optimal experimental parameters for CBZ abatement. Electric current and treatment time were found to be the pivotal parameters influencing the degradation efficiency with respective contributions of 45.19% and 35.44%. The anode material had lower influence on the response, however, using an Nb/BDD anode, the oxidation was more effective due to the increased production of OH radicals as well as HClO, Cl and ClO species. Considering CBZ degradation and energetic consumption, the percentage of degraded CBZ was 88.70 ± 0.35% consuming 1.07 kWh m (at 1.0 A, NaCl concentration of 14 mM after 12.45 min, using Nb/BDD anode). First order kinetic constant (k) value of 0.189 min was obtained at optimal conditions when demineralized water was used for the NaCl supporting electrolyte, while k was lower when tap water or treated wastewaters were used for this purpose. Oxidation of CBZ yielded six aromatic intermediates, identified by gas chromatography - mass spectrometry technique and degradation pathways were proposed. The performed acute toxicity tests indicated an increase during the treatment, which was demonstrated to be mainly attributed to the remnant active chlorine.
[Mh] Termos MeSH primário: Carbamazepina/química
Cloro/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Carbamazepina/toxicidade
Cloretos/química
Cloretos/toxicidade
Cloro/toxicidade
Cinética
Oxirredução
Titânio/química
Águas Residuais/química
Poluentes Químicos da Água/toxicidade
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Waste Water); 0 (Water Pollutants, Chemical); 33CM23913M (Carbamazepine); 4R7X1O2820 (Chlorine); D1JT611TNE (Titanium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171105
[St] Status:MEDLINE


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[PMID]:28745680
[Au] Autor:Belousova ED
[Ad] Endereço:Department of Psychoneurology and Epileptology ,Research and Clincal Institute of Pediatrics, Pirogov Russian National Research Medical University, Moscow, Russia.
[Ti] Título:[The decreased level of plasma carnitine in patients with epilepsy].
[Ti] Título:Snizhenie kontsentratsii karnitina u patsientov s épilepsiei..
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;117(6):106-110, 2017.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Antiepileptic drugs (AEDs) have long been known to affect carnitine metabolism, dropping the plasma free carnitine. Valproate (VPA) was considered to be the strongest carnitine-reducing agent. VPA-induced hyperammonemic encephalopathy and hepatotoxicity are well known, and pre-existing carnitine deficiency can be a predisposing factor, especially in congenital metabolic disorders. Several studies have shown that carnitine supplementation in patients receiving VPA to result in subjective and objective improvements and to prevent VPA-induced hepatotoxicity and encephalopathy, in parallel with increases in carnitine serum concentrations. Level of free plasma carnitine <20 micromol/l (syn. carnitine deficiency) in patients with epilepsy (in 15-30% of cases) may occur not only with administration of VPA but with administration of other AEDs (phenobarbital, phenytoin, carbamazepine) and low nutritional intake of carnitine. Some findings indicate that the number of AEDs used is a risk factor for carnitine deficiency. It was established that body weight, height and multidrug therapy are significantly associated with low level of free plasma in epileptic patients. Carnitine deficiency can have severe consequences; but most epileptic patients suffering from it are asymptomatic. Although carnitine deficiency is not uncommon among patients receiving AEDs, it seems not necessary to routinely monitor carnitine levels in epileptic ambulatory patients, this is reasonable only in groups of risk. L-carnitine supplementation is clearly indicated in case of VPA-induced hepatotoxicity (i.v. administration) VPA overdose (i.v. administration), primary carnitine-transporter defect and is strongly recommended in specific secondary carnitine deficiency syndromes, symptomatic VPA-associated hyperammonemia, infants and young children receiving VPA, especially those younger than 2 years, patients with a complex neurologic disorder, who are receiving multiple AEDs, patients who have risk factors for hepatotoxicity and carnitine insufficiency. In the absence of double blind trials, clinical practice is based on empiric observation, clinical experience, and theory. Well-designed studies of specific and general uses of L-carnitine replacement therapy in patients with epilepsy are needed.
[Mh] Termos MeSH primário: Anticonvulsivantes/efeitos adversos
Cardiomiopatias/induzido quimicamente
Carnitina/sangue
Carnitina/deficiência
Epilepsia/sangue
Epilepsia/tratamento farmacológico
Hiperamonemia/induzido quimicamente
Doenças Musculares/induzido quimicamente
[Mh] Termos MeSH secundário: Anticonvulsivantes/uso terapêutico
Peso Corporal
Carbamazepina/efeitos adversos
Carbamazepina/uso terapêutico
Cardiomiopatias/tratamento farmacológico
Carnitina/uso terapêutico
Criança
Feminino
Seres Humanos
Hiperamonemia/tratamento farmacológico
Lactente
Masculino
Doenças Musculares/tratamento farmacológico
Síndromes Neurotóxicas/tratamento farmacológico
Síndromes Neurotóxicas/etiologia
Fatores de Risco
Ácido Valproico/efeitos adversos
Ácido Valproico/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticonvulsants); 33CM23913M (Carbamazepine); 614OI1Z5WI (Valproic Acid); S7UI8SM58A (Carnitine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.17116/jnevro201711761106-110


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[PMID]:28920921
[Au] Autor:Mullan LA; Mularczyk EJ; Kung LH; Forouhan M; Wragg JM; Goodacre R; Bateman JF; Swanton E; Briggs MD; Boot-Handford RP
[Ad] Endereço:Wellcome Trust Centre for Cell-Matrix Research.
[Ti] Título:Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism.
[So] Source:J Clin Invest;127(10):3861-3865, 2017 Oct 02.
[Is] ISSN:1558-8238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The short-limbed dwarfism metaphyseal chondrodysplasia type Schmid (MCDS) is linked to mutations in type X collagen, which increase ER stress by inducing misfolding of the mutant protein and subsequently disrupting hypertrophic chondrocyte differentiation. Here, we show that carbamazepine (CBZ), an autophagy-stimulating drug that is clinically approved for the treatment of seizures and bipolar disease, reduced the ER stress induced by 4 different MCDS-causing mutant forms of collagen X in human cell culture. Depending on the nature of the mutation, CBZ application stimulated proteolysis of misfolded collagen X by either autophagy or proteasomal degradation, thereby reducing intracellular accumulation of mutant collagen. In MCDS mice expressing the Col10a1.pN617K mutation, CBZ reduced the MCDS-associated expansion of the growth plate hypertrophic zone, attenuated enhanced expression of ER stress markers such as Bip and Atf4, increased bone growth, and reduced skeletal dysplasia. CBZ produced these beneficial effects by reducing the MCDS-associated abnormalities in hypertrophic chondrocyte differentiation. Stimulation of intracellular proteolysis using CBZ treatment may therefore be a clinically viable way of treating the ER stress-associated dwarfism MCDS.
[Mh] Termos MeSH primário: Carbamazepina/farmacologia
Condrócitos/metabolismo
Colágeno Tipo X/biossíntese
Nanismo/metabolismo
Estresse do Retículo Endoplasmático
Mutação
Proteólise
[Mh] Termos MeSH secundário: Fator 4 Ativador da Transcrição/genética
Fator 4 Ativador da Transcrição/metabolismo
Animais
Condrócitos/patologia
Colágeno Tipo X/genética
Nanismo/genética
Nanismo/patologia
Proteínas de Choque Térmico/genética
Proteínas de Choque Térmico/metabolismo
Seres Humanos
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATF4 protein, human); 0 (Atf4 protein, mouse); 0 (Col10a1 protein, mouse); 0 (Collagen Type X); 0 (Heat-Shock Proteins); 0 (molecular chaperone GRP78); 145891-90-3 (Activating Transcription Factor 4); 33CM23913M (Carbamazepine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


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[PMID]:28867586
[Au] Autor:Ghoraba Z; Aibaghi B; Soleymanpour A
[Ad] Endereço:School of Chemistry, Damghan University, Damghan, 3671641167, Iran.
[Ti] Título:Application of cation-modified sulfur nanoparticles as an efficient sorbent for separation and preconcentration of carbamazepine in biological and pharmaceutical samples prior to its determination by high-performance liquid chromatography.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:245-252, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A simple and rapid solid phase extraction procedure using a mini-column packed with modified sulfur nanoparticles as a new, efficient and reusable sorbent has been developed for the preconcentration of carbamazepine prior to its determination by high performance liquid chromatography. This method is based on the retention of carbamazepine by modified sulfur nanoparticles which are quite efficient for fast adsorption and desorption of carbamazepine. An HPLC system including C18, 250×4.6mm column, methanol-acidic water (pH=2.6 by acetic acid) (60:40) as mobile phase and UV detector (λ=276nm) was used. The effects of multiple experimental conditions such as the effect of pH, type and volume of buffer, type and volume of eluent, sample and eluent flow rate, sorbent amount and interfering ions, on the analytical performance of the method were investigated. The calibration curve was linear in the range of 0.5-200ngmL and LOD of the proposed method was found to be 0.16ngmL . The procedure was successfully applied for the determination of carbamazepine in pharmaceutical samples, human plasma and breast milk.
[Mh] Termos MeSH primário: Carbamazepina/análise
Carbamazepina/isolamento & purificação
Cromatografia Líquida de Alta Pressão/métodos
Nanopartículas/química
Extração em Fase Sólida/métodos
Enxofre/química
[Mh] Termos MeSH secundário: Adsorção
Carbamazepina/química
Cátions
Seres Humanos
Modelos Lineares
Leite Humano/química
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Comprimidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Tablets); 33CM23913M (Carbamazepine); 70FD1KFU70 (Sulfur)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


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[PMID]:28857179
[Au] Autor:Androsova G; Krause R; Borghei M; Wassenaar M; Auce P; Avbersek A; Becker F; Berghuis B; Campbell E; Coppola A; Francis B; Wolking S; Cavalleri GL; Craig J; Delanty N; Koeleman BPC; Kunz WS; Lerche H; Marson AG; Sander JW; Sills GJ; Striano P; Zara F; Sisodiya SM; Depondt C; EpiPGX Consortium
[Ad] Endereço:Luxembourg Center for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
[Ti] Título:Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
[So] Source:Epilepsia;58(10):1734-1741, 2017 Oct.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) treatment. Comparative AED effectiveness studies in this condition are lacking. We report retention, efficacy, and tolerability in a cohort of patients with MTLE-HS. METHODS: Clinical data were collected from a European database of patients with epilepsy. We estimated retention, 12-month seizure freedom, and adverse drug reaction (ADR) rates for the 10 most commonly used AEDs in patients with MTLE-HS. RESULTS: Seven hundred sixty-seven patients with a total of 3,249 AED trials were included. The highest 12-month retention rates were observed with carbamazepine (85.9%), valproate (85%), and clobazam (79%). Twelve-month seizure freedom rates varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response rates were highest for AEDs that were prescribed as initial treatment and lowest for AEDs that were used in a third or higher instance. ADRs were reported in 47.6% of patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate (30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin (8.9%), and lamotrigine (16.6%). The most commonly reported ADRs were lethargy and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia. SIGNIFICANCE: Our results did not demonstrate any clear advantage of newer versus older AEDs. Our results provide useful insights into AED retention, efficacy, and ADR rates in patients with MTLE-HS.
[Mh] Termos MeSH primário: Anticonvulsivantes/uso terapêutico
Epilepsia do Lobo Temporal/tratamento farmacológico
Hipocampo/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Aminas/uso terapêutico
Ataxia/induzido quimicamente
Benzodiazepinas/uso terapêutico
Carbamazepina/análogos & derivados
Carbamazepina/uso terapêutico
Ácidos Cicloexanocarboxílicos/uso terapêutico
Bases de Dados Factuais
Diplopia/induzido quimicamente
Tontura/induzido quimicamente
Epilepsia do Lobo Temporal/patologia
Epilepsia do Lobo Temporal/fisiopatologia
Feminino
Frutose/análogos & derivados
Frutose/uso terapêutico
Seres Humanos
Letargia/induzido quimicamente
Masculino
Meia-Idade
Pregabalina/uso terapêutico
Estudos Retrospectivos
Esclerose
Resultado do Tratamento
Triazinas/uso terapêutico
Ácido Valproico/uso terapêutico
Vertigem/induzido quimicamente
Vigabatrina/uso terapêutico
Transtornos da Visão/induzido quimicamente
Adulto Jovem
Ácido gama-Aminobutírico/uso terapêutico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Anticonvulsants); 0 (Cyclohexanecarboxylic Acids); 0 (Triazines); 0H73WJJ391 (topiramate); 12794-10-4 (Benzodiazepines); 2MRO291B4U (clobazam); 30237-26-4 (Fructose); 33CM23913M (Carbamazepine); 55JG375S6M (Pregabalin); 56-12-2 (gamma-Aminobutyric Acid); 614OI1Z5WI (Valproic Acid); 6CW7F3G59X (gabapentin); GR120KRT6K (Vigabatrin); U3H27498KS (lamotrigine); VZI5B1W380 (oxcarbazepine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13871


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[PMID]:28783498
[Au] Autor:Ling L; Zhang D; Fan C; Shang C
[Ad] Endereço:Department of Civil and Environmental Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
[Ti] Título:A Fe(II)/citrate/UV/PMS process for carbamazepine degradation at a very low Fe(II)/PMS ratio and neutral pH: The mechanisms.
[So] Source:Water Res;124:446-453, 2017 Nov 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel Fe(II)/citrate/UV/PMS process for degrading a model micropollutant, carbamazepine (CBZ), at a low Fe(II)/PMS ratio and neutral pH has been proposed in this study, and the mechanisms of radical generation in the system was explored. With a UV dose of 302.4 mJ/cm , an initial pH of 7, and CBZ, PMS, Fe(II) and citrate at initial concentrations of 10, 100, 12 and 26 µM, respectively, the CBZ degradation efficiency reached 71% in 20 min in the Fe(II)/citrate/UV/PMS process, which was 4.7 times higher than that in either the citrate/UV/PMS or Fe(II)/citrate/PMS process. The enhanced CBZ degradation in the Fe(II)/citrate/UV/PMS process was mainly attributed to the continuous activation of PMS by the UV-catalyzed regenerated Fe(II) from a Fe(III)-citrate complex, [Fe O(cit) H ] , which not only maintained Fe(III) soluble at neutral pH, but also increased 6.6 and 2.6 times of its molar absorbance and quantum yield as compared to those of ionic Fe(III), respectively. In the Fe(II)/citrate/UV/PMS process, the SO produced from the fast reaction between PMS and the initially-added Fe(II) contributed 11% of CBZ degradation. The PMS activation by the UV radiation and regenerated Fe(II) contributed additional 14% and 46% of CBZ removal, respectively. The low iron and citrate doses and the fast radical generation at neutral pH make the Fe(II)/citrate/UV/PMS process suitable for degrading recalcitrant organic compounds in potable water.
[Mh] Termos MeSH primário: Carbamazepina/química
Compostos Ferrosos
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Citratos
Ácido Cítrico
Compostos Férricos
Concentração de Íons de Hidrogênio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Citrates); 0 (Ferric Compounds); 0 (Ferrous Compounds); 0 (Water Pollutants, Chemical); 2968PHW8QP (Citric Acid); 33CM23913M (Carbamazepine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE



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