Base de dados : MEDLINE
Pesquisa : D03.633.300.347 [Categoria DeCS]
Referências encontradas : 471 [refinar]
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  1 / 471 MEDLINE  
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[PMID]:26897089
[Au] Autor:Lotesta SD; Marcus AP; Zheng Y; Leftheris K; Noto PB; Meng S; Kandpal G; Chen G; Zhou J; McKeever B; Bukhtiyarov Y; Zhao Y; Lala DS; Singh SB; McGeehan GM
[Ad] Endereço:Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States. Electronic address: slotesta@vitaerx.com.
[Ti] Título:Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.
[So] Source:Bioorg Med Chem;24(6):1384-91, 2016 Mar 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mineralocorticoid receptor (MR) antagonists continue to be a prevalent area of research in the pharmaceutical industry. Herein we report the discovery of various spirooxindole and dibenzoxazepine constructs as potent MR antagonists. SAR analysis of our spirooxindole hit led to highly potent compounds containing polar solubilizing groups, which interact with the helix-11 region of the MR ligand binding domain (LBD). Various dibenzoxazepine moieties were also prepared in an effort to replace a known dibenzoxepane system which interacts with the hydrophobic region of the MR LBD. In addition, an X-ray crystal structure was obtained from a highly potent compound which was shown to exhibit both partial agonist and antagonist modes of action against MR.
[Mh] Termos MeSH primário: Dibenzoxazepinas/farmacologia
Indóis/farmacologia
Antagonistas de Receptores de Mineralocorticoides/farmacologia
Receptores de Mineralocorticoides/metabolismo
Compostos de Espiro/farmacologia
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Dibenzoxazepinas/síntese química
Dibenzoxazepinas/química
Relação Dose-Resposta a Droga
Seres Humanos
Indóis/síntese química
Indóis/química
Antagonistas de Receptores de Mineralocorticoides/síntese química
Antagonistas de Receptores de Mineralocorticoides/química
Modelos Moleculares
Estrutura Molecular
Compostos de Espiro/síntese química
Compostos de Espiro/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Dibenzoxazepines); 0 (Indoles); 0 (Mineralocorticoid Receptor Antagonists); 0 (Receptors, Mineralocorticoid); 0 (Spiro Compounds)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170429
[Lr] Data última revisão:
170429
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160222
[St] Status:MEDLINE


  2 / 471 MEDLINE  
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[PMID]:26771293
[Au] Autor:Zhou Y; Zhu J; Li B; Zhang Y; Feng J; Hall A; Shi J; Zhu W
[Ad] Endereço:CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, P. R. China.
[Ti] Título:Access to Different Isomeric Dibenzoxazepinones through Copper-Catalyzed C-H Etherification and C-N Bond Construction with Controllable Smiles Rearrangement.
[So] Source:Org Lett;18(3):380-3, 2016 Feb 05.
[Is] ISSN:1523-7052
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An efficient new way to access two regio-isomeric dibenzoxazepinones is reported from 8-aminoquinoline benzamides and 2-bromophenols. Through choice of conditions, the reaction proceeds either through a sequential C-H etherification and subsequent Goldberg reaction, both controlled by the aminoquinoline group and Cu(I), or via a C-H etherification and subsequent Smiles rearrangement promoted by Cu(II) and t-BuOK. The 8-aminoquinoline moiety, e.g., 8-amino-5-methoxyquinoline, is readily removable from the structures of dibenzoxazepinones under moderate conditions.
[Mh] Termos MeSH primário: Aminoquinolinas/química
Cobre/química
Dibenzoxazepinas/síntese química
[Mh] Termos MeSH secundário: Catálise
Dibenzoxazepinas/química
Estrutura Molecular
Fenóis/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aminoquinolines); 0 (Dibenzoxazepines); 0 (Phenols); 789U1901C5 (Copper)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160206
[Lr] Data última revisão:
160206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160116
[St] Status:MEDLINE
[do] DOI:10.1021/acs.orglett.5b03378


  3 / 471 MEDLINE  
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[PMID]:26437421
[Au] Autor:Liu N; Song F; Shang F; Huang Y
[Ad] Endereço:State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. fussliu@126.com.
[Ti] Título:Mycemycins A-E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes.
[So] Source:Mar Drugs;13(10):6247-58, 2015 Sep 30.
[Is] ISSN:1660-3397
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Five new dibenzoxazepinone derivatives, mycemycins A-E (1-5), were isolated from the ethanol extracts of mycelia of two different streptomycetes. 1 and 2 were isolated from an acidic red soil-derived strain, Streptomyces sp. FXJ1.235, and 3-5 from a gntR gene-disrupted deep-sea strain named Streptomyces olivaceus FXJ8.012Δ1741. The structures of mycemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques.
[Mh] Termos MeSH primário: Streptomyces/química
[Mh] Termos MeSH secundário: Dibenzoxazepinas/química
Dibenzoxazepinas/isolamento & purificação
Espectroscopia de Ressonância Magnética
Especificidade da Espécie
Análise Espectral/métodos
Streptomyces/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dibenzoxazepines)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151113
[Lr] Data última revisão:
151113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151006
[St] Status:MEDLINE
[do] DOI:10.3390/md13106247


  4 / 471 MEDLINE  
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[PMID]:26075319
[Au] Autor:Braun DE; Koztecki LH; McMahon JA; Price SL; Reutzel-Edens SM
[Ad] Endereço:†Institute of Pharmacy, University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria.
[Ti] Título:Navigating the Waters of Unconventional Crystalline Hydrates.
[So] Source:Mol Pharm;12(8):3069-88, 2015 Aug 03.
[Is] ISSN:1543-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Elucidating the crystal structures, transformations, and thermodynamics of the two zwitterionic hydrates (Hy2 and HyA) of 3-(4-dibenzo[b,f][1,4]oxepin-11-yl-piperazin-1-yl)-2,2-dimethylpropanoic acid (DB7) rationalizes the complex interplay of temperature, water activity, and pH on the solid form stability and transformation pathways to three neutral anhydrate polymorphs (Forms I, II°, and III). HyA contains 1.29 to 1.95 molecules of water per DB7 zwitterion (DB7z). Removal of the essential water stabilizing HyA causes it to collapse to an amorphous phase, frequently concomitantly nucleating the stable anhydrate Forms I and II°. Hy2 is a stoichiometric dihydrate and the only known precursor to Form III, a high energy disordered anhydrate, with the level of disorder depending on the drying conditions. X-ray crystallography, solid state NMR, and H/D exchange experiments on highly crystalline phase pure samples obtained by exquisite control over crystallization, filtration, and drying conditions, along with computational modeling, provided a molecular level understanding of this system. The slow rates of many transformations and sensitivity of equilibria to exact conditions, arising from its varying static and dynamic disorder and water mobility in different phases, meant that characterizing DB7 hydration in terms of simplified hydrate classifications was inappropriate for developing this pharmaceutical.
[Mh] Termos MeSH primário: Cristalização/métodos
Dibenzoxazepinas/química
Preparações Farmacêuticas/química
Piperazinas/química
Propionatos/química
Água/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Cristalografia por Raios X
Espectroscopia de Ressonância Magnética
Modelos Moleculares
Temperatura Ambiente
Termodinâmica
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dibenzoxazepines); 0 (Pharmaceutical Preparations); 0 (Piperazines); 0 (Propionates); 059QF0KO0R (Water)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150616
[St] Status:MEDLINE
[do] DOI:10.1021/acs.molpharmaceut.5b00357


  5 / 471 MEDLINE  
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[PMID]:25875403
[Au] Autor:Yadav N; Khanam T; Shukla A; Rai N; Hajela K; Ramachandran R
[Ad] Endereço:From Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector10, Jankipuram Extension, Sitapur Road, Uttar Pradesh, Lucknow-226031, India. kanchan_hajela@cdri.res.in.
[Ti] Título:Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.
[So] Source:Org Biomol Chem;13(19):5475-87, 2015 May 21.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:DNA ligases are critical components for DNA metabolism in all organisms. NAD(+)-dependent DNA ligases (LigA) found exclusively in bacteria and certain entomopoxviruses are drawing increasing attention as therapeutic targets as they differ in their cofactor requirement from ATP-dependent eukaryotic homologs. Due to the similarities in the cofactor binding sites of the two classes of DNA ligases, it is necessary to find determinants that can distinguish between them for the exploitation of LigA as an anti-bacterial target. In the present endeavour, we have synthesized and evaluated a series of tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives for their ability to distinguish between bacterial and human DNA ligases. The in vivo inhibition assays that employed LigA deficient E. coli GR501 and S. typhimurium LT2 bacterial strains, rescued by ATP-dependent T4 DNA ligase or Mycobacterium tuberculosis NAD(+)-dependent DNA ligase (Mtb LigA), respectively, showed that the compounds can specifically inhibit bacterial LigA. The in vitro enzyme inhibition assays using purified MtbLigA, human DNA ligase I & T4 DNA ligase showed specific inhibition of MtbLigA at low micromolar range. Our results demonstrate that tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can distinguish between bacterial and human DNA ligases by ∼5-folds. In silico docking and enzyme inhibition assays identified that the compounds bind to the cofactor binding site and compete with the cofactor. Ethidium bromide displacement and gel-shift assays showed that the inhibitors do not exhibit any unwanted general interactions with the substrate DNA. These results set the stage for the detailed exploration of this compound class for development as antibacterials.
[Mh] Termos MeSH primário: Bactérias/enzimologia
DNA Ligases/antagonistas & inibidores
Dibenzoxazepinas/farmacologia
Indóis/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
DNA/metabolismo
DNA Ligase Dependente de ATP
DNA Ligases/metabolismo
Dibenzoxazepinas/síntese química
Dibenzoxazepinas/química
Ensaios Enzimáticos
Inibidores Enzimáticos/síntese química
Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Escherichia coli/enzimologia
Seres Humanos
Indóis/síntese química
Indóis/química
Testes de Sensibilidade Microbiana
Simulação de Acoplamento Molecular
Mycobacterium tuberculosis/enzimologia
Salmonella typhimurium/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Dibenzoxazepines); 0 (Enzyme Inhibitors); 0 (Indoles); 0 (LIG1 protein, human); 9007-49-2 (DNA); EC 6.5.1.- (DNA Ligases); EC 6.5.1.1 (DNA Ligase ATP)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150416
[St] Status:MEDLINE
[do] DOI:10.1039/c5ob00439j


  6 / 471 MEDLINE  
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[PMID]:25466191
[Au] Autor:Lynch SM; Tafesse L; Carlin K; Ghatak P; Kyle DJ
[Ad] Endereço:Discovery Research, Purdue Pharma LP, 6 Cedarbrook Drive, Cranbury, NJ 08512, United States.
[Ti] Título:Dibenzazepines and dibenzoxazepines as sodium channel blockers.
[So] Source:Bioorg Med Chem Lett;25(1):43-7, 2015 Jan 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
[Mh] Termos MeSH primário: Dibenzazepinas/química
Dibenzoxazepinas/química
Canal de Sódio Disparado por Voltagem NAV1.7/fisiologia
Bloqueadores dos Canais de Sódio/química
[Mh] Termos MeSH secundário: Animais
Dibenzazepinas/farmacologia
Dibenzoxazepinas/farmacologia
Seres Humanos
Microssomos Hepáticos/efeitos dos fármacos
Microssomos Hepáticos/fisiologia
Ratos
Bloqueadores dos Canais de Sódio/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dibenzazepines); 0 (Dibenzoxazepines); 0 (NAV1.7 Voltage-Gated Sodium Channel); 0 (Sodium Channel Blockers); J411KQJ8C2 (dibenzazepine)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141204
[St] Status:MEDLINE


  7 / 471 MEDLINE  
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[PMID]:24935166
[Au] Autor:Pandey S; Kumar SV; Kant R; Chauhan PM
[Ad] Endereço:Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. Premsc58@hotmail.com prem_chauhan_2000@yahoo.com.
[Ti] Título:Base mediated 7-exo-dig intramolecular cyclization of Ugi-propargyl precursors: a highly efficient and regioselective synthetic approach toward diverse 1,4-benzoxazepine-5(2H)-ones.
[So] Source:Org Biomol Chem;12(29):5346-50, 2014 Aug 07.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A metal-free facile and efficient two-step synthetic protocol for the preparation of 1,4-benzoxazepine-5(2H)-one derivatives has been developed. The protocol involves Ugi reaction followed by K2CO3 mediated highly regioselective 7-exo-dig intramolecular cyclization of less-nucleophilic oxygen with the pendant alkyne moiety of an Ugi-propargyl precursor to afford the 1,4-benzoxazepine-5(2H)-one derivatives in good to excellent yields.
[Mh] Termos MeSH primário: Alquinos/química
Química Orgânica/métodos
Dibenzoxazepinas/síntese química
[Mh] Termos MeSH secundário: Ciclização
Dibenzoxazepinas/química
Conformação Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkynes); 0 (Dibenzoxazepines)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140702
[Lr] Data última revisão:
140702
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140618
[St] Status:MEDLINE
[do] DOI:10.1039/c4ob00793j


  8 / 471 MEDLINE  
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[PMID]:23265904
[Au] Autor:Deng Y; Yang Z; Shipps GW; Lo SM; West R; Hwa J; Zheng S; Farley C; Lachowicz J; van Heek M; Bass AS; Sinha DP; Mahon CR; Cartwright ME
[Ad] Endereço:Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA. yongqi.deng@merck.com
[Ti] Título:Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).
[So] Source:Bioorg Med Chem Lett;23(3):791-6, 2013 Feb 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inhibitors based on a benzo-fused spirocyclic oxazepine scaffold were discovered for stearoyl-coenzyme A (CoA) desaturase 1 (SCD1) and subsequently optimized to potent compounds with favorable pharmacokinetic profiles and in vivo efficacy in reducing the desaturation index in a mouse model. Initial optimization revealed potency preferences for the oxazepine core and benzylic positions, while substituents on the piperidine portions were more tolerant and allowed for tuning of potency and PK properties. After preparation and testing of a range of functional groups on the piperidine nitrogen, three classes of analogs were identified with single digit nanomolar potency: glycine amides, heterocycle-linked amides, and thiazoles. Responding to concerns about target localization and potential mechanism-based side effects, an initial effort was also made to improve liver concentration in an available rat PK model. An advanced compound 17m with a 5-carboxy-2-thiazole substructure appended to the spirocyclic piperidine scaffold was developed which satisfied the in vitro and in vivo requirements for more detailed studies.
[Mh] Termos MeSH primário: Dibenzoxazepinas/síntese química
Sistemas de Liberação de Medicamentos
Inibidores Enzimáticos/síntese química
Fígado/enzimologia
Estearoil-CoA Dessaturase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Ciclização
Dibenzoxazepinas/farmacocinética
Dibenzoxazepinas/farmacologia
Ativação Enzimática/efeitos dos fármacos
Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Camundongos
Modelos Animais
Estrutura Molecular
Ratos
Compostos de Espiro/síntese química
Compostos de Espiro/farmacocinética
Compostos de Espiro/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dibenzoxazepines); 0 (Enzyme Inhibitors); 0 (Spiro Compounds); EC 1.14.19.1 (Stearoyl-CoA Desaturase)
[Em] Mês de entrada:1306
[Cu] Atualização por classe:130114
[Lr] Data última revisão:
130114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121226
[St] Status:MEDLINE


  9 / 471 MEDLINE  
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[PMID]:23272563
[Au] Autor:Kovalev AV; Tolmachev SI; Mukovskii LA; Khrustaleva IuA
[Ti] Título:[The biological activity of the irritant dibenz-[b,f] - [1,4]-oxazepine (substance CR) persisting during a long period at the environmental objects].
[So] Source:Sud Med Ekspert;55(5):38-41, 2012 Sep-Oct.
[Is] ISSN:0039-4521
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The objective of the present study was to determine the biological activity of the irritant dibenz-[B,F]-[1,4]-oxazepine (substance CR) contained in the environmental samples in case of their "closed" storage during different periods of time. The experiments were carried out using male and female rabbits of the Chinchilla strain with the initial body mass of 3000-4000 g. The animals were administered an aqueous alcoholic extract from the tissue samples of the rabbit eye coat as described in the "Methodological guidelines on the medico-biological assessment of the safety of personal protection devices". The results of experiments indicate that extracts from tissue samples elicit irritation in the eyes of the laboratory animals even after their storage as long as 600 days. This observation suggests that substance CR retains the ability to cause irritation during a prolonged period.
[Mh] Termos MeSH primário: Dibenzoxazepinas/toxicidade
Poluentes Ambientais/toxicidade
Olho/efeitos dos fármacos
Irritantes/toxicidade
Gases Lacrimogênios/toxicidade
[Mh] Termos MeSH secundário: Animais
Dibenzoxazepinas/química
Estabilidade de Medicamentos
Poluentes Ambientais/química
Feminino
Irritantes/química
Masculino
Coelhos
Gases Lacrimogênios/química
Têxteis
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dibenzoxazepines); 0 (Environmental Pollutants); 0 (Irritants); 0 (Tear Gases); C1Q77A87V1 (dibenz(b,f)(1,4)oxazepine)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130101
[St] Status:MEDLINE


  10 / 471 MEDLINE  
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[PMID]:22876644
[Au] Autor:Kovalev AV; Tolmachev SI; Mukovskii LA; Khrustaleva IuA
[Ti] Título:[On the stability of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR)].
[So] Source:Sud Med Ekspert;55(3):15-8, 2012 May-Jun.
[Is] ISSN:0039-4521
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The objective of the present study was to determine the duration and conditions of persistence of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR) on the environmental objects. The quantitative analysis of the substance on cotton fabric specimens was carried out using the approved method of high performance liquid chromatography (HPLC) with UV detection at different time periods and envirobmental conditions. It was shown that the main factor determining the lifetime of dibenz-[b,f]-[1,4]-oxazepine on the cotton fabric is the ambient conditions. By way of example, the "open" and "closed", storage of such specimens during 300 days resulted in the decrease of the amount of substance CR to 22.5 and 79% of the initial level respectively. By the end experiment (day 600) these values lowered to 3 and 52.5% respectively. Taken together, the results of the study indicate that dibenz-[b,f]-[1,4]-oxazepine can be described as a substance resistant to environmental impacts. It is comparable in terms of stability with such known irritants as capsicum oleoresin and pelargonic acid morpholide.
[Mh] Termos MeSH primário: Dibenzoxazepinas/análise
Toxicologia Forense/métodos
Gases Lacrimogênios/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Dibenzoxazepinas/toxicidade
Estabilidade de Medicamentos
Relação Estrutura-Atividade
Gases Lacrimogênios/toxicidade
Têxteis/análise
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dibenzoxazepines); 0 (Tear Gases); C1Q77A87V1 (dibenz(b,f)(1,4)oxazepine)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120811
[St] Status:MEDLINE



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