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[PMID]: 28954370 [Au] Autor: Qiao L; Zheng XB; Yan X; Wang MH; Zheng J; Chen SJ; Yang ZY; Mai BX [Ad] Endereço: State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. [Ti] Título: Brominated flame retardant (BFRs) and Dechlorane Plus (DP) in paired human serum and segmented hair. [So] Source: Ecotoxicol Environ Saf;147:803-808, 2018 Jan. [Is] ISSN: 1090-2414 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Brominated flame retardants (BFRs) and Dechlorane Plus (DP) were measured in both human hair and paired serum samples from a cohort of university students in South China. Segmental analysis was conducted to explore gender difference and the relationships between the hair and serum. The concentrations of total PBDEs in the hair and serum samples were in a range of 0.28-34.1ng/g dry weight (dw) and 0.16-156ng/g lipid weight (lw), respectively. Concentrations of ∑DPs (sum of the syn-DP and anti-DP isomers) in all hair samples ranged from nd-5.45ng/g dry weight. Concentrations of most PBDEs and decabromodiphenylethane (DBDPE) in distal segments (5-10cm from the scalp) were higher than those in the proximal segments (0-5cm from the scalp) (t-test, p < 0.05), which could be due to the longer exposure time of distal segments. The proximal segments exhibited a unique congener profile, more close to that in the serum rather than the distal segments of hair. An obvious gender difference was found in the levels of ∑PBDEs using integrated hair samples, while the difference disappeared when considering alone the proximal segments of hair (0-5cm from scalp) for both genders. This paper provides supplement to the current knowledge on sources of BFRs and DPs in hair and declares the importance of segmental analysis. [Mh] Termos MeSH primário: Monitoramento Ambiental/métodos Retardadores de Chama/análise Cabelo/química Éteres Difenil Halogenados/sangue Hidrocarbonetos Bromados/sangue Hidrocarbonetos Clorados/sangue Compostos Policíclicos/sangue [Mh] Termos MeSH secundário: China Feminino Cromatografia Gasosa-Espectrometria de Massas Éteres Difenil Halogenados/análise Seres Humanos Hidrocarbonetos Bromados/análise Hidrocarbonetos Clorados/análise Masculino Compostos Policíclicos/análise Fatores Sexuais [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Flame Retardants); 0 (Halogenated Diphenyl Ethers); 0 (Hydrocarbons, Brominated); 0 (Hydrocarbons, Chlorinated); 0 (Polycyclic Compounds); 0 (dechlorane plus) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170929 [St] Status: MEDLINE

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[PMID]: 29184406 [Au] Autor: Yuan M; Ding S; Meng T; Lu B; Shao S; Zhang X; Yuan H; Hu F [Ad] Endereço: Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan. [Ti] Título: Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain. [So] Source: Int J Nanomedicine;12:8171-8183, 2017. [Is] ISSN: 1178-2013 [Cp] País de publicação: New Zealand [La] Idioma: eng [Ab] Resumo: Endometriosis is a common gynecological disease with a lack of effective clinical treatment. Current therapy often results in endometriosis pain recurrence and serious side effects. P2X receptor, an adenosine triphosphate (ATP)-gated ion channel, might be implicated in endometriosis pain. In this study, chitosan oligosaccharide-g-stearic acid (CSOSA) polymer micelles-coated nanostructured lipid carriers (NLCs) were developed as a novel delivery system for A-317491, a selective P2X receptor antagonist for endometriosis pain therapy. A-317491-loaded NLC (NLC/A-317491) could be coated by CSOSA micelles to form CSOSA/NLC/A-317491 nanoparticles. Pheochromocytoma PC12 cells, which highly expressed P2X receptors, were used as a cell model, and the CSOSA/NLC/A-317491 partly blocked the Ca influx induced by ATP stimulation. In nude mouse and rat endometriotic models, CSOSA/NLC could accumulate into endometriotic lesions after vein injection. In endometriotic rats, CSOSA/NLC/A-317491 reversed mechanical and heat hyperalgesia with long-term efficacy, which might be attributed to the massive CSOSA/NLC/A-317491 distribution in the endometriotic lesions. In conclusion, A-317491 delivered by CSOSA/NLC nanoparticles attenuated endometriosis pain in rats, and CSOSA/NLC/A-317491 could be used as an effective treatment strategy for P2X -targeted therapy in endometriosis pain. [Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos/métodos Endometriose/tratamento farmacológico Nanopartículas/administração & dosagem Dor/tratamento farmacológico Fenóis/administração & dosagem Compostos Policíclicos/administração & dosagem [Mh] Termos MeSH secundário: Animais Feminino Glicolipídeos/química Seres Humanos Camundongos Nus Micelas Nanopartículas/química Oligossacarídeos/química Células PC12 Fenóis/química Fenóis/farmacologia Compostos Policíclicos/química Compostos Policíclicos/farmacologia Polímeros/química Antagonistas do Receptor Purinérgico P2X/farmacologia Ratos Receptores Purinérgicos P2X3 Ácidos Esteáricos/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (A-317491); 0 (Glycolipids); 0 (Micelles); 0 (Oligosaccharides); 0 (Phenols); 0 (Polycyclic Compounds); 0 (Polymers); 0 (Purinergic P2X Receptor Antagonists); 0 (Receptors, Purinergic P2X3); 0 (Stearic Acids); 4ELV7Z65AP (stearic acid) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171130 [St] Status: MEDLINE [do] DOI: 10.2147/IJN.S146569

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[PMID]: 28744886 [Au] Autor: Zhao A; Zhang L; Li R; Shang J; Yi H; Wang Y; Zhang D; Wang S; Fang M [Ad] Endereço: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, China. [Ti] Título: Development and validation of an LC-MS/MS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription. [So] Source: Biomed Chromatogr;32(2), 2018 Feb. [Is] ISSN: 1099-0801 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A sensitive, specific and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of seven constituents of the Zaoren Anshen prescription (ZAP) in rat plasma after oral administration of the ZAP: spinosin, salvianic acid A, 6'''-feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin. The plasma samples and the internal standard (IS) sulfamethoxazole were extracted using acetonitrile. Chromatographic separation was performed with an Agilent HC-C column using a gradient elution profile and a mobile phase consisting of 0.01% formic acid in water (A) and acetonitrile (B). The analytes were quantified simultaneously in a single run using an ion trap mass spectrometer operated in the multiple reaction monitoring mode and electrospray ion-source polarity in the positive and negative modes. The calibration curves for spinosin, salvianic acid A, 6'''-feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin were linear over the concentration ranges of 2.90-1160, 2.50-1000, 1.80-720, 0.65-260, 2.50-1000, 8.00-1600 and 1.30-520 ng/mL, respectively. The intra- and inter-day precisions in terms of relative standard deviation were <18.9%, and the accuracies in terms of relative error were within ±14.2%. Consequently, the proposed method was successfully applied to the pharmacokinetic analysis of these seven major active compounds in rats administered ZAP. These results will facilitate research aiming to predict the effectiveness of the optimal dose of ZAP and might be beneficial for the therapeutic use of ZAP in the clinical setting. [Mh] Termos MeSH primário: Benzaldeídos/sangue Benzofuranos/sangue Catecóis/sangue Ciclo-Octanos/sangue Medicamentos de Ervas Chinesas/farmacocinética Flavonoides/sangue Lignanas/sangue Compostos Policíclicos/sangue [Mh] Termos MeSH secundário: Animais Benzaldeídos/química Benzaldeídos/farmacocinética Benzofuranos/química Benzofuranos/farmacocinética Catecóis/química Catecóis/farmacocinética Cromatografia Líquida/métodos Ciclo-Octanos/química Ciclo-Octanos/farmacocinética Estabilidade de Medicamentos Medicamentos de Ervas Chinesas/análise Medicamentos de Ervas Chinesas/química Flavonoides/química Flavonoides/farmacocinética Lignanas/química Lignanas/farmacocinética Limite de Detecção Modelos Lineares Masculino Compostos Policíclicos/química Compostos Policíclicos/farmacocinética Ratos Ratos Sprague-Dawley Reprodutibilidade dos Testes Espectrometria de Massas em Tandem/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Benzaldehydes); 0 (Benzofurans); 0 (Catechols); 0 (Cyclooctanes); 0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Lignans); 0 (Polycyclic Compounds); 4PVP2HCH4T (protocatechualdehyde); 72063-39-9 (spinosin); C1GQ844199 (salvianolic acid B); G01BQC0879 (schizandrin) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170727 [St] Status: MEDLINE [do] DOI: 10.1002/bmc.4055

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[PMID]: 29199256 [Au] Autor: Saito N [Ad] Endereço: Graduate School of Pharmaceutical Sciences, Tohoku University. [Ti] Título: [Synthesis, Aggregation, Self-assembly, and Dynamic Properties of Helicene Oligomers]. [So] Source: Yakugaku Zasshi;137(12):1483-1490, 2017. [Is] ISSN: 1347-5231 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: Biological systems exhibit dynamic phenomena at the macroscopic level as a result of the hierarchical integration of phenomena at the molecular level. For example, a number of amino acids compose actin proteins, which form three-dimensional structures determined by the sequence of amino acids. They form fibers by self-assembly, which then form ordered structures such as meshes, lyotropic liquid crystals (LCs), and bundles. The dynamic and reversible polymorphism between these nano- to centimeter-sized ordered structures is essential for biological functions such as cell division, contraction, and locomotion. To understand biological systems and create new functional materials, it is essential to develop a methodology to integrate phenomena at the molecular level into those at the macroscopic level using synthetic molecules. In this research, synthetic oligomers containing helicenes, which exhibit reversible structural transitions between cylindrical double helices and random coils in response to thermal stimuli, were employed as building blocks for the development of such a methodology. The properties of homo- and hetero-double helices at the molecular level were first controlled by taking advantage of the diversity of their molecular structures. Then, nano- to micrometer-sized structures were constructed by the self-assembly of hetero-double helices, which include fibers/gels, vesicles, and lyotropic LCs, and their dynamic properties were controlled by molecular design. [Mh] Termos MeSH primário: Fenômenos Biológicos Compostos Policíclicos [Mh] Termos MeSH secundário: Animais Disciplinas das Ciências Biológicas Biopolímeros Fenômenos Fisiológicos Celulares Química Orgânica Sequências Hélice-Alça-Hélice Seres Humanos Biologia Molecular Estrutura Molecular Nanopartículas Compostos Policíclicos/química Compostos Policíclicos/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Biopolymers); 0 (Polycyclic Compounds); 0 (helicenes) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180112 [Lr] Data última revisão: 180112 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171205 [St] Status: MEDLINE [do] DOI: 10.1248/yakushi.17-00130

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[PMID]: 29289283 [Au] Autor: Morin NAO; Andersson PL; Hale SE; Arp HPH [Ad] Endereço: Norwegian Geotechnical Institute (NGI), P.O. Box 3930, Ullevål Stadion, N-0806 Oslo, Norway; Environmental and Food Laboratory of Vendée (LEAV), Department of Chemistry, Rond-point Georges Duval CS 80802, 85021 La Roche-sur-Yon, France. Electronic address: nicolasmorin@live.fr. [Ti] Título: The presence and partitioning behavior of flame retardants in waste, leachate, and air particles from Norwegian waste-handling facilities. [So] Source: J Environ Sci (China);62:115-132, 2017 Dec. [Is] ISSN: 1001-0742 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Flame retardants in commercial products eventually make their way into the waste stream. Herein the presence of flame retardants in Norwegian landfills, incineration facilities and recycling sorting/defragmenting facilities is investigated. These facilities handled waste electrical and electronic equipment (WEEE), vehicles, digestate, glass, combustibles, bottom ash and fly ash. The flame retardants considered included polybrominated diphenyl ethers (∑BDE-10) as well as dechlorane plus, polybrominated biphenyls, hexabromobenzene, pentabromotoluene and pentabromoethylbenzene (collectively referred to as ∑FR-7). Plastic, WEEE and vehicles contained the largest amount of flame retardants (∑BDE-10: 45,000-210,000µg/kg; ∑FR-7: 300-13,000µg/kg). It was hypothesized leachate and air concentrations from facilities that sort/defragment WEEE and vehicles would be the highest. This was supported for total air phase concentrations (∑BDE-10: 9000-195,000pg/m WEEE/vehicle facilities, 80-900pg/m in incineration/sorting and landfill sites), but not for water leachate concentrations (e.g., ∑BDE-10: 15-3500ng/L in WEEE/Vehicle facilities and 1-250ng/L in landfill sites). Landfill leachate exhibited similar concentrations as WEEE/vehicle sorting and defragmenting facility leachate. To better account for concentrations in leachates at the different facilities, waste-water partitioning coefficients, K were measured (for the first time to our knowledge for flame retardants). WEEE and plastic waste had elevated K compared to other wastes, likely because flame retardants are directly added to these materials. The results of this study have implications for the development of strategies to reduce exposure and environmental emissions of flame retardants in waste and recycled products through improved waste management practices. [Mh] Termos MeSH primário: Poluentes Atmosféricos/análise Monitoramento Ambiental Retardadores de Chama/análise Instalações de Eliminação de Resíduos Poluentes Químicos da Água/análise [Mh] Termos MeSH secundário: Bromobenzenos/análise Resíduo Eletrônico/análise Éteres Difenil Halogenados/análise Hidrocarbonetos Clorados/análise Noruega Plásticos Bifenil Polibromatos/análise Compostos Policíclicos/análise Gerenciamento de Resíduos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Air Pollutants); 0 (Bromobenzenes); 0 (Flame Retardants); 0 (Halogenated Diphenyl Ethers); 0 (Hydrocarbons, Chlorinated); 0 (Plastics); 0 (Polybrominated Biphenyls); 0 (Polycyclic Compounds); 0 (Water Pollutants, Chemical); 0 (dechlorane plus); T01859XWIR (hexabromobenzene) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180103 [Lr] Data última revisão: 180103 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180101 [St] Status: MEDLINE

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[PMID]: 28465627 [Au] Autor: Falzone M; Crespo E; Jones K; Khan G; Korn VL; Patel A; Patel M; Patel K; Perkins C; Siddiqui S; Stenger D; Yu E; Gelber M; Scheffler R; Nayda V; Ravin A; Komal R; Rudolf JD; Shen B; Gullo V; Demain AL [Ad] Endereço: Research Institute of Scientists Emeriti (RISE), Charles A. Dana Research Institute, Drew University, Madison, NJ, USA. [Ti] Título: Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid. [So] Source: J Antibiot (Tokyo);70(7):828-831, 2017 Jul. [Is] ISSN: 0021-8820 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: Streptomyces platensis MA7327 is a bacterium producing interesting antibiotics, which act by the novel mechanism of inhibiting fatty acid biosynthesis. The antibiotics produced by this actinomycete are platensimycin and platencin plus some minor related antibiotics. Platensimycin and platencin have activity against antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus; they also lack toxicity in animal models. Platensimycin also has activity against diabetes in a mouse model. We have been interested in studying the effects of primary metabolites on production of these antibiotics in our chemically defined production medium. In the present work, we tested 32 primary metabolites for their effect. They included 20 amino acids, 7 vitamins and 5 nucleic acid derivatives. Of these, only l-aspartic acid showed stimulation of antibiotic production. We conclude that the stimulatory effect of aspartic acid is due to its role as a precursor involved in the biosynthesis of aspartate-4-semialdehyde, which is the starting point for the biosynthesis of the 3-amino-2,4-dihydroxy benzoic acid portion of the platensimycin molecule. [Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação Ácido Aspártico/administração & dosagem Streptomyces/metabolismo [Mh] Termos MeSH secundário: Adamantano/isolamento & purificação Aminoácidos/administração & dosagem Aminoácidos/metabolismo Aminobenzoatos/isolamento & purificação Aminofenóis/isolamento & purificação Anilidas/isolamento & purificação Antibacterianos/biossíntese Ácido Aspártico/química Ácidos Nucleicos/administração & dosagem Ácidos Nucleicos/metabolismo Compostos Policíclicos/isolamento & purificação Vitaminas/administração & dosagem Vitaminas/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Amino Acids); 0 (Aminobenzoates); 0 (Aminophenols); 0 (Anilides); 0 (Anti-Bacterial Agents); 0 (Nucleic Acids); 0 (Polycyclic Compounds); 0 (Vitamins); 0 (platencin); 30KYC7MIAI (Aspartic Acid); PJY633525U (Adamantane); Q3DQ78KOFY (platensimycin) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 180101 [Lr] Data última revisão: 180101 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE [do] DOI: 10.1038/ja.2017.49

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[PMID]: 28818768 [Au] Autor: Poornima B; Siva B; Venkanna A; Shankaraiah G; Jain N; Yadav DK; Misra S; Babu KS [Ad] Endereço: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India. [Ti] Título: Novel Gomisin B analogues as potential cytotoxic agents: Design, synthesis, biological evaluation and docking studies. [So] Source: Eur J Med Chem;139:441-453, 2017 Oct 20. [Is] ISSN: 1768-3254 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: As part of pharmacological-phytochemical integrated studies on medicinal flora, Gomisin B (1) was isolated as major phytochemical lead from schisandra grandiflora, a plant traditionally used in different Asian systems of medicine. A series of 1,2,3-triazoles derivatives were synthesized at the C-7' position of the gomisin B core through diastereoselective Michael addition followed by regioselective Huisgen 1,3-dipolar cycloaddition reactions. All these triazolyl derivatives (5a-5q) were well characterized using modern spectroscopic techniques and evaluated for their anti-cancer activity against a panel of five human cancerous cell-lines. Among them, compound 5b exhibited the best cytotoxicity against SIHA cell (IC 0.24 µM) which was more than the standard drug doxorubicin, while the other derivatives were exhibited moderate to low activities in tested cell lines. The cell cycle analysis indicated that compound 5b stalled HeLa cells at G2/M phase. 5b promoted tubulin polymerization and this was supported by the docking studies, wherein 5b showed significant binding affinity at the colchicine binding pocket of tubulin. Overall, we identified a novel small molecule that demonstrated anticancer activity by promoting in vitro tubulin assembly. [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Citotoxinas/farmacologia Dioxóis/farmacologia Desenho de Drogas Lignanas/farmacologia Simulação de Acoplamento Molecular Compostos Policíclicos/farmacologia [Mh] Termos MeSH secundário: Antineoplásicos/síntese química Antineoplásicos/química Linhagem Celular Tumoral Proliferação Celular/efeitos dos fármacos Ciclo-Octanos/síntese química Ciclo-Octanos/química Ciclo-Octanos/farmacologia Citotoxinas/síntese química Citotoxinas/química Dioxóis/síntese química Dioxóis/química Relação Dose-Resposta a Droga Ensaios de Seleção de Medicamentos Antitumorais Seres Humanos Lignanas/síntese química Lignanas/química Estrutura Molecular Compostos Policíclicos/síntese química Compostos Policíclicos/química Schisandra/química Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Cyclooctanes); 0 (Cytotoxins); 0 (Dioxoles); 0 (Lignans); 0 (Polycyclic Compounds); 58546-55-7 (schisantherin B) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171018 [Lr] Data última revisão: 171018 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170819 [St] Status: MEDLINE

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[PMID]: 28696837 [Au] Autor: Jacobsen ML; Jaspers VLB; Ciesielski TM; Jenssen BM; Løseth ME; Briels N; Eulaers I; Leifsson PS; Rigét FF; Gomez-Ramirez P; Sonne C [Ad] Endereço: a Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences , University of Copenhagen , Frederiksberg , Denmark. [Ti] Título: Japanese quail (Coturnix japonica) liver and thyroid gland histopathology as a result of in ovo exposure to the flame retardants tris(1,3-dichloro-2-propyl) phosphate and Dechlorane Plus. [So] Source: J Toxicol Environ Health A;80(9):525-531, 2017. [Is] ISSN: 1528-7394 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Japanese quails (Coturnix japonica) were exposed in ovo to tris(1,3-dichloro-2-propyl) phosphate (TDCIPP; 500 ng/µl), Dechlorane Plus (DP; 500 ng/µl), or a 1:1 mixture of these two to investigate the effects on liver and thyroid gland morphology. Histological examination of 14-day-old quails showed that exposure to TDCIPP or the mixture induced hepatic sinusoidal dilatation. No marked effects were seen for DP alone. In addition, the mixture produced divergence of thyroid gland follicles and proliferation of follicular cells. Our study is the first demonstrating histopathological alterations as a result of exposure during early development to the flame retardants TDCIPP or a TDCIPP-DP mixture suggesting the need for further research efforts to investigate potential adverse health effects associated with exposure to these environmental chemicals in wild birds. [Mh] Termos MeSH primário: Coturnix/crescimento & desenvolvimento Retardadores de Chama/toxicidade Hidrocarbonetos Clorados/toxicidade Fígado/efeitos dos fármacos Óvulo/efeitos dos fármacos Compostos Policíclicos/toxicidade Glândula Tireoide/efeitos dos fármacos [Mh] Termos MeSH secundário: Animais [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Flame Retardants); 0 (Hydrocarbons, Chlorinated); 0 (Polycyclic Compounds) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170906 [Lr] Data última revisão: 170906 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170712 [St] Status: MEDLINE [do] DOI: 10.1080/15287394.2017.1336414

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[PMID]: 28672702 [Au] Autor: Zhou S; Fu J; He H; Fu J; Tang Q; Dong M; Pan Y; Li A; Liu W; Zhang L [Ad] Endereço: College of Environment, Zhejiang University of Technology, Hangzhou 310032, China. [Ti] Título: Spatial distribution and implications to sources of halogenated flame retardants in riverine sediments of Taizhou, an intense e-waste recycling area in eastern China. [So] Source: Chemosphere;184:1202-1208, 2017 Oct. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Concentrations and spatial distribution pattern of organohalogen flame retardants were investigated in the riverine surface sediments from Taizhou, an intensive e-waste recycling region in China. The analytes were syn- and anti- Dechlorane Plus (DP), Dechloranes 602, 603, and 604, a DP monoadduct, two dechlorinated DPs and 8 congeners of polybrominated diphenyl ethers (PBDEs). The concentrations of Σ PBDEs, ΣDP, ΣDec600s, and ΣDP-degradates ranged from <100 to 172,000, 100 to 55,000, not detectable (nd) to 1600, and nd to 2800 pg/g dry weight, respectively. BDE-209 and DP, both have been manufactured in China, had similar spatial distribution patterns in the study area, featured by distinctly recognizable hotspots some of which are in proximity to known e-waste dumping or metal recycling facilities. Such patterns were largely shared by Dec602 and dechlorinated DP, although their concentration levels were much lower. These major flame retardants significantly correlate with each other, and cluster together in the loading plot of principle component analysis. In contrast, most non-deca PBDE congeners do not correlate with DPs. Dec604 stood out having distinctly different spatial distribution pattern, which could be linked to historical use of mirex. Organic matter content of the sediment was not the dominant factor in determining the spatial pattern of pollution by halogenated flame retardants in the rivers of this study. [Mh] Termos MeSH primário: Resíduo Eletrônico Monitoramento Ambiental Retardadores de Chama/análise Poluentes Químicos da Água/análise [Mh] Termos MeSH secundário: China Sedimentos Geológicos/química Éteres Difenil Halogenados/análise Halogenação Hidrocarbonetos Clorados/análise Compostos Policíclicos/análise Reciclagem Rios [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Flame Retardants); 0 (Halogenated Diphenyl Ethers); 0 (Hydrocarbons, Chlorinated); 0 (Polycyclic Compounds); 0 (Water Pollutants, Chemical); 0 (dechlorane 602); 0 (dechlorane plus); N80BQ29A0H (decabromobiphenyl ether) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171006 [Lr] Data última revisão: 171006 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170705 [St] Status: MEDLINE

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[PMID]: 28636798 [Au] Autor: Piontek A; Witte C; May Rose H; Eichner M; Protze J; Krause G; Piontek J; Schröder L [Ad] Endereço: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Structural Bioinformatics and Protein Design, Berlin, Germany. [Ti] Título: A cCPE-based xenon biosensor for magnetic resonance imaging of claudin-expressing cells. [So] Source: Ann N Y Acad Sci;1397(1):195-208, 2017 Jun. [Is] ISSN: 1749-6632 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The majority of malignant tumors originate from epithelial cells, and many of them are characterized by an overexpression of claudins (Cldns) and their mislocalization out of tight junctions. We utilized the C-terminal claudin-binding domain of Clostridium perfringens enterotoxin (cCPE), with its high affinity to specific members of the claudin family, as the targeting unit for a claudin-sensitive cancer biosensor. To overcome the poor sensitivity of conventional relaxivity-based magnetic resonance imaging (MRI) contrast agents, we utilized the superior sensitivity of xenon Hyper-CEST biosensors. We labeled cCPE for both xenon MRI and fluorescence detection. As one readout module, we employed a cryptophane (CrA) monoacid and, as the second, a fluorescein molecule. Both were conjugated separately to a biotin molecule via a polyethyleneglycol chemical spacer and later via avidin linked to GST-cCPE. Nontransfected HEK293 cells and HEK293 cells stably expressing Cldn4-FLAG were incubated with the cCPE-based biosensor. Fluorescence-based flow cytometry and xenon MRI demonstrated binding of the biosensor specifically to Cldn4-expressing cells. This study provides proof of concept for the use of cCPE as a carrier for diagnostic contrast agents, a novel approach for potential detection of Cldn3/-4-overexpressing tumors for noninvasive early cancer detection. [Mh] Termos MeSH primário: Técnicas Biossensoriais/métodos Claudina-4/metabolismo Enterotoxinas/metabolismo Imagem por Ressonância Magnética/métodos Xenônio/química [Mh] Termos MeSH secundário: Avidina/química Claudina-3/química Claudina-3/genética Claudina-3/metabolismo Claudina-4/química Claudina-4/genética Enterotoxinas/química Enterotoxinas/genética Citometria de Fluxo Fluoresceínas/química Células HEK293 Seres Humanos Microscopia Confocal Modelos Moleculares Compostos Policíclicos/química Polietilenoglicóis/química Ligação Proteica Estrutura Terciária de Proteína Reprodutibilidade dos Testes [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Claudin-3); 0 (Claudin-4); 0 (Enterotoxins); 0 (Fluoresceins); 0 (Polycyclic Compounds); 0 (cryptophane A); 0 (enterotoxin, Clostridium); 1405-69-2 (Avidin); 30IQX730WE (Polyethylene Glycols); 3H3U766W84 (Xenon) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170822 [Lr] Data última revisão: 170822 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170622 [St] Status: MEDLINE [do] DOI: 10.1111/nyas.13363

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