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[PMID]:28850889
[Au] Autor:Abushareeda W; Lyris E; Kraiem S; Wahaibi AA; Alyazidi S; Dbes N; Lommen A; Nielen M; Horvatovich PL; Alsayrafi M; Georgakopoulos C
[Ad] Endereço:Anti-Doping Lab Qatar, Sports City, P.O. Box. 27775, Doha, Qatar.
[Ti] Título:Gas chromatographic quadrupole time-of-flight full scan high resolution mass spectrometric screening of human urine in antidoping analysis.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:74-83, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This paper presents the development and validation of a high-resolution full scan (FS) electron impact ionization (EI) gas chromatography coupled to quadrupole Time-of-Flight mass spectrometry (GC/QTOF) platform for screening anabolic androgenic steroids (AAS) in human urine samples. The World Antidoping Agency (WADA) enlists AAS as prohibited doping agents in sports, and our method has been developed to comply with the qualitative specifications of WADA to be applied for the detection of sports antidoping prohibited substances, mainly for AAS. The method also comprises of the quantitative analysis of the WADA's Athlete Biological Passport (ABP) endogenous steroidal parameters. The applied preparation of urine samples includes enzymatic hydrolysis for the cleavage of the Phase II glucuronide conjugates, generic liquid-liquid extraction and trimethylsilyl (TMS) derivatization steps. Tandem mass spectrometry (MS/MS) acquisition was applied on few selected ions to enhance the specificity and sensitivity of GC/TOF signal of few compounds. The full scan high resolution acquisition of analytical signal, for known and unknown TMS derivatives of AAS provides the antidoping system with a new analytical tool for the detection designer drugs and novel metabolites, which prolongs the AAS detection, after electronic data files' reprocessing. The current method is complementary to the respective liquid chromatography coupled to mass spectrometry (LC/MS) methodology widely used to detect prohibited molecules in sport, which cannot be efficiently ionized with atmospheric pressure ionization interface.
[Mh] Termos MeSH primário: Anabolizantes/urina
Doping nos Esportes/prevenção & controle
Cromatografia Gasosa-Espectrometria de Massas/métodos
[Mh] Termos MeSH secundário: Androsterona/urina
Criança
Epitestosterona/urina
Feminino
Seres Humanos
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); 481-30-1 (Epitestosterone); C24W7J5D5R (Androsterone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


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[PMID]:28380041
[Au] Autor:Trautmann J; Meier-Dinkel L; Gertheiss J; Mörlein D
[Ad] Endereço:Department of Animal Sciences, Meat Science Group, University of Göttingen, Göttingen, Germany.
[Ti] Título:Noise and accustomation: A pilot study of trained assessors' olfactory performance.
[So] Source:PLoS One;12(4):e0174697, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While recent studies suggest an influence of noise on olfactory performance, it is unclear as to what extent the influence varies between subjects who are accustomed to noise and those who are not. Two groups of panelists were selected: a University panel usually working under silent conditions and an abattoir panel usually working on the slaughter line with abattoir noise. Odor discrimination, odor identification, and odor detection thresholds were studied. Furthermore, a sensory quality control task using 40 boar samples was performed. All tests were accomplished both with and without extraneous noise recorded at an abattoir (70 dB) using headphones. Contrary to the researchers' expectations, abattoir noise hardly affected the olfactory tests nor was the quality control task impaired. Abattoir noise did not influence the perceived intensity of boar taint and the classification results of the testers, regardless of whether they were accustomed to such noise or not. The results indicate that sensory quality control can be conducted in a manufacturing environment with constant noise without diminishing the assessors' performance.
[Mh] Termos MeSH primário: Ruído/efeitos adversos
Olfato/fisiologia
[Mh] Termos MeSH secundário: Matadouros
Estimulação Acústica
Tecido Adiposo/química
Adulto
Androsterona/análise
Animais
Seres Humanos
Masculino
Carne/normas
Meia-Idade
Odorantes
Projetos Piloto
Limiar Sensorial
Escatol/análise
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9W945B5H7R (Skatole); C24W7J5D5R (Androsterone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170910
[Lr] Data última revisão:
170910
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174697


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[PMID]:28139245
[Au] Autor:Vehof J; Hysi PG; Hammond CJ
[Ad] Endereço:Department of Twin Research & Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, United Kingdom; Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, United Kingdom; Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: jelle.vehof@kcl.ac.uk.
[Ti] Título:A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers.
[So] Source:Ophthalmology;124(4):505-511, 2017 Apr.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach. DESIGN: Cross-sectional association study. PARTICIPANTS: A total of 2819 subjects from the population-representative TwinsUK cohort in the United Kingdom, with a mean age of 57 years (range, 17-82 years). METHODS: We tested associations between 222 known serum metabolites and DED. All subjects underwent nontargeted metabolomic analysis of plasma samples using gas and liquid chromatography in combination with mass spectrometry (Metabolon Inc., Durham, NC). Dry eye disease was defined from the validated Short Questionnaire for Dry Eye Syndrome (SQDES) as a previous diagnosis of DED by a clinician or "often" or "constant" symptoms of dryness and irritation. Analyses were performed with linear mixed effect models that included age, BMI, and sex as covariates, corrected for multiple testing. MAIN OUTCOME MEASURES: Primary outcome was DED as defined by the SQDES, and secondary outcomes were symptom score of DED and a clinical diagnosis of DED. RESULTS: Prevalence of DED as defined by the SQDES was 15.5% (n = 436). A strong and metabolome-wide significant association with DED was found with decreased levels of the metabolites androsterone sulfate (P = 0.00030) and epiandrosterone sulfate (P = 0.00036). Three other metabolites involved in androgen metabolism, 4-androsten-3beta,17beta-diol disulfate 1 and 2, and dehydroepiandrosterone sulfate, were the next most strongly associated of the 222 metabolites, but did not reach metabolome-wide significance. Dryness and irritation symptoms, as opposed to a clinical diagnosis, were particularly strongly associated with decreased androgen steroid metabolites, with all reaching metabolome-wide significance (androsterone sulfate, P = 0.000000029; epiandrosterone sulfate, P = 0.0000040; 4-androsten-3beta,17beta-diol disulfate 1, P = 0.000016; 4-androsten-3beta,17beta-diol disulfate 2, P = 0.000064; and dehydroepiandrosterone sulfate, P = 0.00011). Of these 5 androgens, epiandrosterone sulfate (P = 0.0076) was most associated with 2-year incidence of clinician-diagnosed DED. In addition, we found decreased glycerophosphocholines to be associated with DED, although not at metabolome-wide significance. CONCLUSIONS: This hypothesis-free metabolomic approach found decreased serum androgens to be highly associated with DED and adds important evidence to the growing body of research that links androgens to ocular surface disease and DED.
[Mh] Termos MeSH primário: Androgênios/sangue
Biomarcadores/sangue
Síndromes do Olho Seco/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Androstenodióis/sangue
Androsterona/análogos & derivados
Androsterona/sangue
Estudos de Coortes
Estudos Transversais
Sulfato de Desidroepiandrosterona/sangue
Síndromes do Olho Seco/diagnóstico
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Masculino
Metaboloma
Meia-Idade
Fatores de Risco
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; TWIN STUDY
[Nm] Nome de substância:
0 (Androgens); 0 (Androstenediols); 0 (Biomarkers); 1852-61-5 (4-androstene-3,17-diol); 57B09Q7FJR (Dehydroepiandrosterone Sulfate); C24W7J5D5R (Androsterone); UK5M12Z93J (androsterone sulfate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE


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[PMID]:28114737
[Au] Autor:D'Souza-Anjo M; Christensen BW; Brabender K; Zimmermann W; Kass PH; Schwarzenberger F
[Ad] Endereço:University of California, Davis, California.
[Ti] Título:A comparison of fecal steroid metabolite concentrations between harem and bachelor stallions in a free-Ranging population of przewalski's horses (Equus ferus przewalskii).
[So] Source:Zoo Biol;36(2):127-131, 2017 Mar.
[Is] ISSN:1098-2361
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to determine whether concentrations of reproductive steroid hormone metabolites significantly differed between harem stallions and bachelor stallions in the free ranging group of Przewalski's horses (Equus ferus przewalskii) at the Hortobágy National Park in Hungary. Throughout the study, fecal samples were collected from 21 harem stallions and 15 bachelor stallions and analyzed for immunoreactive estrogen and androgen metabolites. Harem stallions demonstrated significantly higher concentrations of estrogen (P < 0.001) and epi-androsterone (P < 0.001), but not testosterone (P = 0.426). These findings confirm that sociosexual status has a significant effect on androgen concentrations in individual Przewalski stallions. Zoo Biol. 36:127-131, 2017. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Androsterona/análise
Estrogênios/análise
Fezes/química
Cavalos/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais de Zoológico
Masculino
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); C24W7J5D5R (Androsterone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1002/zoo.21348


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[PMID]:27913096
[Au] Autor:Ke Y; Gonthier R; Labrie F
[Ad] Endereço:EndoCeutics Inc., 2795 Laurier Blvd, Suite 500, Quebec City, QC G1V 4M7, Canada. Electronic address: yke2005@gmail.com.
[Ti] Título:A sensitive and accurate LC-MS/MS assay with the derivatization of 1-Amino-4-methylpiperazine applied to serum allopregnanolone, pregnenolone and androsterone in pre- and postmenopausal women.
[So] Source:Steroids;118:25-31, 2017 Feb.
[Is] ISSN:1878-5867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The concentrations of allopregnanolone (Allopreg), pregnenolone (Preg) and androsterone (ADT) are very low in the circulation, especially in postmenopausal women, resulting in a considerable challenge for their accurate measurements in serum or plasma. In this report, a sensitive and reliable LC-MS/MS assay method has been developed using a simple sample preparation and the 1-Amino-4-methylpiperazine (AMP) derivatization procedure. A 5pg/ml (0.1pg on column) of low limit of quantitation has been achieved for Allopreg, Preg and ADT, with a sensitivity comparable to data obtained with the commercial reagent. The major benefit of this reagent is to limit the matrix effect since the excess amount of reagent can be removed during the reaction. Multiple reaction monitoring (MRM) from the derivatization of AMP not only increases the detection of these compounds but also provides a good resolution for Allopreg, Preg and ADT from interferences, especially for Allopreg from its isomers. Within the calibration range of 5pg/ml to 2000pg/ml, a good linearity was obtained with R>0.99 where the weighing factor is 1/X. Bias and coefficients of variance are within 15% for all QC levels. The matrix effect has been evaluated, well meeting the acceptance criteria according to the FDA guidelines. With this method, the concentrations of Allopreg, Preg and ADT in postmenopausal serum are in the range of 6.4-53.6pg/ml, 16.2-68.0pg/ml and 23.9-114.0pg/ml, respectively, while the ranges in premenopausal serum are 8.2-701.5pg/ml, 31.2-135.2pg/ml and 47.8-310.0pg/ml, respectively.
[Mh] Termos MeSH primário: Androsterona/sangue
Cromatografia Líquida/métodos
Piperazinas/química
Pós-Menopausa/sangue
Pregnanolona/sangue
Pregnenolona/sangue
Pré-Menopausa/sangue
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Androsterona/química
Bioensaio/métodos
Feminino
Seres Humanos
Estrutura Molecular
Pregnanolona/química
Pregnenolona/química
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1-amino-4-methylpiperazine); 0 (Piperazines); 73R90F7MQ8 (Pregnenolone); BXO86P3XXW (Pregnanolone); C24W7J5D5R (Androsterone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161204
[St] Status:MEDLINE


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[PMID]:27885948
[Au] Autor:Jacob CC; Dervilly-Pinel G; Deceuninck Y; Gicquiau A; Chevillon P; Bonneau M; Le Bizec B
[Ad] Endereço:a LUNAM ONIRIS, École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique , Laboratoire d'Étude des Résidus et Contaminants dans les aliments (LABERCA) , Nantes , France.
[Ti] Título:Urinary signature of pig carcasses with boar taint by liquid chromatography-high-resolution mass spectrometry.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;34(2):218-227, 2017 Feb.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Boar taint is an offensive odour that can occur while cooking pork or pork products and is identified in some uncastrated male pigs that have reached puberty. It is widely held that boar taint is the result of the accumulation in back fat of two malodorous compounds: androstenone and skatole. The purpose of this study is to assess a mass spectrometry-based metabolomics strategy to investigate the metabolic profile of urine samples from pig carcasses presenting low (untainted) and high (tainted) levels of androstenone and skatole in back fat. Urine samples were analysed by LC-ESI(+)-HRMS. Discrimination between tainted and untainted animals was observed by the application of multivariate statistical analysis, which allowed candidate urinary biomarkers to be highlighted. These urinary metabolites were positively correlated to androstenone and skatole levels in back fat. Therefore, the study suggests that the measurement of these urinary metabolites might provide information with regard to androstenone and skatole levels in live pigs.
[Mh] Termos MeSH primário: Androsterona/urina
Escatol/urina
Suínos/urina
[Mh] Termos MeSH secundário: Androsterona/metabolismo
Animais
Cromatografia Líquida
Masculino
Espectrometria de Massas
Metabolômica
Análise Multivariada
Escatol/metabolismo
Suínos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9W945B5H7R (Skatole); C24W7J5D5R (Androsterone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2016.1265152


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[PMID]:27871978
[Au] Autor:Frey AJ; Park BY; Schriver ER; Feldman DR; Parry S; Croen LA; Fallin DM; Hertz-Picciotto I; Newschaffer CJ; Snyder NW
[Ad] Endereço:AJ Drexel Autism Institute, Drexel University, 3020 Market St, Suite 560, Philadelphia, PA 19104, USA.
[Ti] Título:Differences in testosterone and its precursors by sex of the offspring in meconium.
[So] Source:J Steroid Biochem Mol Biol;167:78-85, 2017 Mar.
[Is] ISSN:1879-1220
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Prenatal metabolism exerts profound effects on development. The first stool of the newborn, meconium, provides a window into the prenatal metabolic environment. The objective of this study was to examine the feasibility of meconium as a novel matrix to quantify prenatal steroid levels. We quantified parameters of analytical interest regarding the use of meconium, including sample stability. We hypothesized that meconium steroid content would differ by sex, prompting analysis of meconium to test effects of prenatal steroid metabolism. Meconium from 193 newborns enrolled in the Early Autism Risk Longitudinal Investigation (EARLI) study, including 107 males, and 86 females, were analyzed by isotope dilution-liquid chromatography-high resolution mass spectrometry (ID-LC-HRMS) while blinded to identity for testosterone (T), androstenedione (AD), and dehydroepiandrosterone (DHEA). Steroid levels were compared by sex, and investigations of potential trends resulting from sample storage or processing was conducted. The unconjugated steroid content of meconium in ng/g (mean, standard deviation) was for males: T (2.67, 8.99), AD (20.01, 28.12), DHEA (13.96, 23.57) and for females: T (0.82, 1.63), AD (22.32, 24.38), DHEA (21.06, 43.49). T was higher in meconium from males (p=0.0333), and DHEA was higher in meconium from females (p=0.0202). 6 female and 3 male T values were below the limit of detection. No extreme variability in hydration or trend in steroid levels by storage time was detected. Sexually dimorphic levels of hormones may reflect gestational differentiation, and future studies should consider meconium analysis.
[Mh] Termos MeSH primário: Androsterona/química
Desidroepiandrosterona/química
Mecônio/química
Testosterona/química
[Mh] Termos MeSH secundário: Androstenodiona/química
Cromatografia Líquida
Estudos de Coortes
Feminino
Seres Humanos
Recém-Nascido
Masculino
Espectrometria de Massas
Fatores Sexuais
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3XMK78S47O (Testosterone); 409J2J96VR (Androstenedione); 459AG36T1B (Dehydroepiandrosterone); C24W7J5D5R (Androsterone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170704
[Lr] Data última revisão:
170704
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE


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[PMID]:27845856
[Au] Autor:Jones CM; Mallappa A; Reisch N; Nikolaou N; Krone N; Hughes BA; O'Neil DM; Whitaker MJ; Tomlinson JW; Storbeck KH; Merke DP; Ross RJ; Arlt W
[Ad] Endereço:Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
[Ti] Título:Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia.
[So] Source:J Clin Endocrinol Metab;102(6):1797-1806, 2017 Jun 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: The classic androgen synthesis pathway proceeds via dehydroepiandrosterone, androstenedione, and testosterone to 5α-dihydrotestosterone. However, 5α-dihydrotestosterone synthesis can also be achieved by an alternative pathway originating from 17α-hydroxyprogesterone (17OHP), which accumulates in congenital adrenal hyperplasia (CAH). Similarly, recent work has highlighted androstenedione-derived 11-oxygenated 19-carbon steroids as active androgens, and in CAH, androstenedione is generated directly from 17OHP. The exact contribution of alternative pathway activity to androgen excess in CAH and its response to glucocorticoid (GC) therapy is unknown. Objective: We sought to quantify classic and alternative pathway-mediated androgen synthesis in CAH, their diurnal variation, and their response to conventional GC therapy and modified-release hydrocortisone. Methods: We used urinary steroid metabolome profiling by gas chromatography-mass spectrometry for 24-hour steroid excretion analysis, studying the impact of conventional GCs (hydrocortisone, prednisolone, and dexamethasone) in 55 adults with CAH and 60 controls. We studied diurnal variation in steroid excretion by comparing 8-hourly collections (23:00-7:00, 7:00-15:00, and 15:00-23:00) in 16 patients with CAH taking conventional GCs and during 6 months of treatment with modified-release hydrocortisone, Chronocort. Results: Patients with CAH taking conventional GCs showed low excretion of classic pathway androgen metabolites but excess excretion of the alternative pathway signature metabolites 3α,5α-17-hydroxypregnanolone and 11ß-hydroxyandrosterone. Chronocort reduced 17OHP and alternative pathway metabolite excretion to near-normal levels more consistently than other GC preparations. Conclusions: Alternative pathway-mediated androgen synthesis significantly contributes to androgen excess in CAH. Chronocort therapy appears superior to conventional GC therapy in controlling androgen synthesis via alternative pathways through attenuation of their major substrate, 17OHP.
[Mh] Termos MeSH primário: Hiperplasia Suprarrenal Congênita/tratamento farmacológico
Androgênios/secreção
Ritmo Circadiano
Glucocorticoides/administração & dosagem
Hidrocortisona/administração & dosagem
[Mh] Termos MeSH secundário: 17-alfa-Hidroxipregnenolona/urina
Adolescente
Hiperplasia Suprarrenal Congênita/metabolismo
Hiperplasia Suprarrenal Congênita/urina
Adulto
Androsterona/análogos & derivados
Androsterona/urina
Cortodoxona/análogos & derivados
Cortodoxona/urina
Preparações de Ação Retardada
Dexametasona/uso terapêutico
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Glucocorticoides/uso terapêutico
Seres Humanos
Hidrocortisona/uso terapêutico
Masculino
Meia-Idade
Prednisolona/uso terapêutico
Pregnanotriol/análogos & derivados
Pregnanotriol/urina
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgens); 0 (Delayed-Action Preparations); 0 (Glucocorticoids); 27178-64-9 (Pregnanetriol); 387-79-1 (17-alpha-Hydroxypregnenolone); 57-61-4 (11 beta-hydroxyandrosterone); 603-99-6 (pregnanetriolone); 68-60-0 (tetrahydro-11-deoxycortisol); 7S5I7G3JQL (Dexamethasone); 9PHQ9Y1OLM (Prednisolone); C24W7J5D5R (Androsterone); WDT5SLP0HQ (Cortodoxone); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-2855


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[PMID]:27647631
[Au] Autor:Chou FP; Tsai CT; Chiou YS; Chen YJ; Li ME; Guo TW; Lyu JW; Chou SH; Wu TK
[Ad] Endereço:Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, R.O.C.
[Ti] Título:An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application.
[So] Source:Chem Biol Drug Des;89(1):61-66, 2017 Jan.
[Is] ISSN:1747-0285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.
[Mh] Termos MeSH primário: Androsterona/química
Antineoplásicos/química
Glucosídeos/química
[Mh] Termos MeSH secundário: Antineoplásicos/farmacologia
Glucosídeos/farmacologia
Conformação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Glucosides); C24W7J5D5R (Androsterone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.1111/cbdd.12830


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[PMID]:27579788
[Au] Autor:Corral S; Belloch C; López-Díez JJ; Salvador A; Flores M
[Ad] Endereço:Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Avda. Agustín Escardino 7, 46980 Paterna, Valencia, Spain.
[Ti] Título:Yeast inoculation as a strategy to improve the physico-chemical and sensory properties of reduced salt fermented sausages produced with entire male fat.
[So] Source:Meat Sci;123:1-7, 2017 Jan.
[Is] ISSN:1873-4138
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Yeast inoculation of dry fermented sausages manufactured with entire male fat was evaluated as a strategy to improve sausage quality. Four different formulations with entire male/gilt back fat and inoculated/non-inoculated with Debaryomyces hansenii were manufactured. The use of entire male back fat produced the highest weight losses, hardness and chewiness in dry sausages. Consumers clearly distinguished samples according to drying time and D. hansenii inoculation while the use of entire/gilt back fat was not highly perceived. The presence of androstenone and skatole was close to their sensory thresholds. Androstenone was not degraded during the process but skatole was affected by yeast inoculation. D. hansenii growth on the surface regulated water release during ripening, reduced hardness and chewiness in entire male sausages and resulted with similar texture to gilt sausages. Yeast inoculation inhibited lipid oxidation providing fruity odours and less oxidized fatty sausages in the sensory analysis. The effectiveness of yeast to mask boar taint was demonstrated by sensory analysis.
[Mh] Termos MeSH primário: Tecido Adiposo/química
Produtos da Carne/análise
Saccharomycetales
Leveduras
[Mh] Termos MeSH secundário: Adulto
Androsterona/análise
Cor
Comportamento do Consumidor
Dessecação
Gorduras na Dieta/análise
Feminino
Microbiologia de Alimentos
Qualidade dos Alimentos
Seres Humanos
Lactobacillus
Masculino
Meia-Idade
Escatol/química
Olfato
Cloreto de Sódio na Dieta/análise
Staphylococcus
Paladar
Substâncias Reativas com Ácido Tiobarbitúrico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Sodium Chloride, Dietary); 0 (Thiobarbituric Acid Reactive Substances); 9W945B5H7R (Skatole); C24W7J5D5R (Androsterone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160901
[St] Status:MEDLINE



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