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[PMID]:27771087
[Au] Autor:Zhou B; Chen B; Wu X; Li F; Yu P; Aguilar ZP; Wei H; Xu H
[Ad] Endereço:State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, PR China.
[Ti] Título:A new application of a sodium deoxycholate-propidium monoazide-quantitative PCR assay for rapid and sensitive detection of viable Cronobacter sakazakii in powdered infant formula.
[So] Source:J Dairy Sci;99(12):9550-9559, 2016 Dec.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A rapid, reliable, and sensitive method for the detection of Cronobacter sakazakii, a common foodborne pathogen that may cause serious neonatal disease, has been developed. In this study, a rapid real-time quantitative PCR (qPCR) assay combined with sodium deoxycholate (SD) and propidium monoazide (PMA) was developed to detect C. sakazakii contamination in powdered infant formula (PIF). This method could eliminate the interference from dead or injured bacteria. Optimization studies indicated that SD and PMA at 0.08% (wt/vol) and 5µg/mL, respectively, were the most appropriate. In addition, qPCR, PMA-qPCR, SD-PMA-qPCR, and plate count assays were used to account for the number of viable bacteria in cell suspensions that were exposed to a 55°C water bath at different length of time. As a result, the viable number by PMA-qPCR showed significantly higher than of the number from SD-PMA-qPCR or plate counts. The number of viable bacteria was consistent between SD-PMA-qPCR and traditional plate counts, which indicated that SD treatment could eliminate the interference from dead or injured cells. Using the optimized parameters, the limit of detection with the SD-PMA-qPCR assay was 3.3×10 cfu/mL and 4.4×10 cfu/g in pure culture and in spiked PIF, respectively. A similar detection limit of 5.6×10 cfu/g was obtained in the presence of the Staphylococcus aureus (10 cfu/mL). The combined SD-PMA-qPCR assay holds promise for the rapid detection of viable C. sakazakii in PIF.
[Mh] Termos MeSH primário: Cronobacter sakazakii/genética
Fórmulas Infantis
[Mh] Termos MeSH secundário: Animais
Azidas
Ácido Desoxicólico
Microbiologia de Alimentos
Viabilidade Microbiana
Propídio
Reação em Cadeia da Polimerase em Tempo Real
Staphylococcus aureus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azides); 005990WHZZ (Deoxycholic Acid); 36015-30-2 (Propidium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29064990
[Au] Autor:Rotunda AM; Marcello LT
[Ad] Endereço:Department of Medicine (Dermatology), David Geffen School of Medicine, University of California, Los Angeles, California Department of Dermatology, University of California, Irvine, California Private Practice, Newport Beach, California Cornell University Ithaca, New York.
[Ti] Título:Commentary on ATX-101 (Deoxycholic Acid Injection) Treatment in Men.
[So] Source:Dermatol Surg;43 Suppl 2:S231-S234, 2017 11.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Ácido Desoxicólico
Injeções
[Mh] Termos MeSH secundário: Técnicas Cosméticas
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
005990WHZZ (Deoxycholic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001378


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[PMID]:28902021
[Au] Autor:Shridharani SM; Behr KL
[Ad] Endereço:*Private Practice (LUXURGERY), New York, New York; †Private Practice (Behr Laser and Skin Care Center), Fresno, California.
[Ti] Título:ATX-101 (Deoxycholic Acid Injection) Treatment in Men: Insights From Our Clinical Experience.
[So] Source:Dermatol Surg;43 Suppl 2:S225-S230, 2017 Nov.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Excess submental fat (SMF), also called a double chin, is an area of concern for men that can be addressed clinically. ATX-101 (deoxycholic acid injection; Kybella in the United States and Belkyra in Canada, Australia, and various European countries) is the first injectable approved for reduction of SMF. OBJECTIVE: To share the authors' clinical experience using ATX-101 in men with submental fullness and offer insights regarding how this treatment may be presented to men as an option to improve their submental profile. METHODS: Retrospective review of the authors' medical records for male patients treated with ATX-101. RESULTS: To allow for fewer ATX-101 treatments, it is recommended that a large surface area be treated at the first session. The positive changes and outcomes achieved with ATX-101 build confidence between the physician and patient, which often leads to male patients seeking other aesthetic treatments to improve their overall appearance. CONCLUSION: ATX-101 treatment is often an effective introduction to aesthetic medicine for men.
[Mh] Termos MeSH primário: Queixo
Técnicas Cosméticas
Ácido Desoxicólico/uso terapêutico
Estética
Gordura Subcutânea/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Ácido Desoxicólico/administração & dosagem
Seres Humanos
Injeções Subcutâneas
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
005990WHZZ (Deoxycholic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001306


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[PMID]:28865757
[Au] Autor:Menotti J; Alanio A; Sturny-Leclère A; Vitry S; Sauvage F; Barratt G; Bretagne S
[Ad] Endereço:Institut Pasteur, CNRS, Molecular Mycology unit, URA3012 Paris, France; Laboratory of Parasitology-Mycology, Saint-Louis Lariboisière Fernand Widal hospitals, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Paris-Diderot, Sorbonne Paris Cité University, Paris, France; Laboratory of Par
[Ti] Título:A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations.
[So] Source:Toxicol Appl Pharmacol;334:18-23, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aerosolized liposomal amphotericin B (L-AmB) has been investigated as prophylaxis against invasive aspergillosis. However, the clinical results are controversial and some trials suggest that toxicity could be a limitation for wider use. Our aim was to assess the dynamics of cell toxicity induced in a human alveolar epithelial cell line (A549) after exposure to L-AmB (50 to 400µg/ml) or amphotericin B deoxycholate (D-AmB; 50 to 200µg/ml) by monitoring real-time A549 cell viability using an impedance-based technology. Results were expressed as cell index values integrating cell adhesion, proliferation, and survival. In parallel, the gene expression of proinflammatory cytokines was quantified at 6 and 24h after drug addition by real-time RT-PCR on cell lysates. No sustained reduction of cell indexes was observed with L-AmB or empty liposomes, even at 400µg/ml. Only the highest concentration tested of L-AmB (400µg/ml) yielded transient significant 6-fold and 4-fold induction of TNF-α and IL-8 mRNAs, respectively. In contrast, D-AmB induced a decrease in cell indexes and only the 50µg/ml concentration of D-AmB was followed by cell recovery, higher concentrations leading to cell death. Significant 4-fold, 7-fold and 3-fold inductions of TNF-α, IL-8 and IL-33 mRNAs were also observed at 6h with 50µg/ml of D-AmB. In conclusion, continuous cell impedance measurement showed no toxicity on overall cellular behavior although a slight proinflammatory cytokine expression is possible after L-AmB challenge. Real-time kinetics of cell impedance is an interesting tool for initial screening of cell toxicity.
[Mh] Termos MeSH primário: Aerossóis/toxicidade
Anfotericina B/toxicidade
Antifúngicos/toxicidade
Ácido Desoxicólico/toxicidade
Impedância Elétrica
Células Epiteliais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células A549
Anfotericina B/química
Antifúngicos/química
Adesão Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Citocinas/genética
Citocinas/metabolismo
Formas de Dosagem
Combinação de Medicamentos
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Antifungal Agents); 0 (Cytokines); 0 (Dosage Forms); 0 (Drug Combinations); 0 (liposomal amphotericin B); 005990WHZZ (Deoxycholic Acid); 7XU7A7DROE (Amphotericin B); 87687-70-5 (amphotericin B, deoxycholate drug combination)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE


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[PMID]:28697447
[Au] Autor:Fraenza CC; Anoardo E
[Ad] Endereço:Laboratorio de Relaxometría y Técnicas Especiales (LaRTE), Grupo de Resonancia Magnética Nuclear, Facultad de Matemática, Astronomía y Física, Universidad Nacional de Córdoba and IFEG - CONICET, Ciudad Universitaria X5000HUA, Córdoba, Argentina.
[Ti] Título:Dynamical regimes of lipids in additivated liposomes with enhanced elasticity: A field-cycling NMR relaxometry approach.
[So] Source:Biophys Chem;228:38-46, 2017 Sep.
[Is] ISSN:1873-4200
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We study the molecular dynamics of lipids in binary large unilamellar liposomes suspended in D O composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or soy phosphatidylcholine (SPC) additivated with different percentiles of sodium deoxycholate (SDC). We use the fast field-cycling proton NMR relaxometry technique over a wide timescale and at diverse temperatures. A model previously validated in different formulations is here employed for the relaxometric analysis of elastic vesicles. A new dynamical regime is observed for the first time in additivated DMPC and additivated/non-additivated SPC liposomes. This surprising feature is discussed in terms of vesicle shape fluctuations, enhanced elasticity and lipid & additive diffusion within the membrane. The continuum elastic theory is revisited for a better understanding of recent experiments and those here presented. We address the point of deformability measurements across rigid permeable barriers versus measurements of the bending elastic modulus in free-standing vesicles.
[Mh] Termos MeSH primário: Lipossomos/química
Espectroscopia de Ressonância Magnética
[Mh] Termos MeSH secundário: Ácido Desoxicólico/química
Dimiristoilfosfatidilcolina/química
Elasticidade
Fosfatidilcolinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Liposomes); 0 (Phosphatidylcholines); 005990WHZZ (Deoxycholic Acid); U86ZGC74V5 (Dimyristoylphosphatidylcholine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE


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[PMID]:28688958
[Au] Autor:Popadyuk II; Markov AV; Babich VO; Salomatina OV; Logashenko EB; Zenkova MA; Salakhutdinov NF
[Ad] Endereço:N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch Russian Academy of Sciences, 9, Lavrent'ev ave., Novosibirsk 630090, Russian Federation. Electronic address: popadyuk@nioch.nsc.ru.
[Ti] Título:Novel derivatives of deoxycholic acid bearing aliphatic or cyclic diamine moieties at the C-3 position: Synthesis and evaluation of anti-proliferative activity.
[So] Source:Bioorg Med Chem Lett;27(16):3755-3759, 2017 08 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new library of deoxycholic acid derivatives bearing nitrogen-containing moieties at the C-3 position was synthesised from epoxy derivative 1 via an epoxide ring-opening reaction promoted by aliphatic or cyclic diamines and fully characterised by NMR and mass-spectroscopy. The synthesised compounds were screened for cytotoxicity against four human tumour cell lines. The results showed that some of the novel diamine-bearing derivatives displayed improved anti-proliferative activities over the parent compound DCA. Among them, a 1-methylpiperazine containing compound (6) showed promising activity and the highest selectivity against tumour cells of enterohepatic origin (HepG2: IC =3.6µM, SI=9.0; HuTu-80: IC =4.6µM, SI=6.9) and was identified as a lead molecule.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Ácido Desoxicólico/farmacologia
Diaminas/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Ácido Desoxicólico/síntese química
Ácido Desoxicólico/química
Diaminas/síntese química
Diaminas/química
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Diamines); 005990WHZZ (Deoxycholic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170710
[St] Status:MEDLINE


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[PMID]:28673256
[Au] Autor:Wang RY; Chen YQ; Wu JQ; Wang X; Cao YH; Zhao HZ; Zhu LP
[Ad] Endereço:Department of Infectious Diseases, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai, China.
[Ti] Título:Cryptococcosis in patients with hematological diseases: a 14-year retrospective clinical analysis in a Chinese tertiary hospital.
[So] Source:BMC Infect Dis;17(1):463, 2017 Jul 03.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cryptococcal infection has become a public health challenge globally. However, information about cryptococcal infection in patients with hematological diseases remains relatively rare. METHODS: HIV-uninfected cryptococcosis cases with hematological diseases admitted to Huashan Hospital from January 2001 to December 2014 were reviewed. RESULTS: In total, 33 cryptococcosis patients were enrolled, including 12 malignant and 21 non-malignant hematological cases. Twenty-six patients had central nervous system (CNS) involvement, which was observed more often in patients with non-malignancies than with malignancies (20/21 vs. 6/12, P = 0.001) Most patients (25/26) with CNS infection were confirmed by cerebrospinal fluid (CSF) culture or smear, and 100% (20/20) of them tested positive for the CSF cryptococcal antigen test. Eighteen out of 26 cryptococcal meningitis patients were treated with amphotericin B (AmB)-based therapy, 16 of them with AmB deoxycholate (d-AmB) and 2 patients with liposomal AmB. The clinical success rate was 55.6%. D-AmB was well-tolerated at 0.35-0.59 mg/kg/d (median 0.43 mg/kg/d) and only 12 patients had mild adverse events. CONCLUSIONS: CNS cryptococcal infection was more frequent in patients with hematological non-malignancies, and cryptococcal antigen test as well as the CSF fungal culture or smear are suggested for early diagnosis. D-AmB could be used as an alternative therapy for CNS-infected patients with hematological diseases.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Criptococose/etiologia
Doenças Hematológicas/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Anfotericina B/uso terapêutico
Infecções Fúngicas do Sistema Nervoso Central/tratamento farmacológico
Infecções Fúngicas do Sistema Nervoso Central/microbiologia
Criptococose/tratamento farmacológico
Ácido Desoxicólico/uso terapêutico
Combinação de Medicamentos
Feminino
Doenças Hematológicas/complicações
Neoplasias Hematológicas/complicações
Neoplasias Hematológicas/microbiologia
Seres Humanos
Masculino
Meningite Criptocócica/tratamento farmacológico
Meia-Idade
Prognóstico
Estudos Retrospectivos
Fatores de Risco
Centros de Atenção Terciária
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Drug Combinations); 0 (liposomal amphotericin B); 005990WHZZ (Deoxycholic Acid); 7XU7A7DROE (Amphotericin B); 87687-70-5 (amphotericin B, deoxycholate drug combination)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2561-z


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[PMID]:28648257
[Au] Autor:García MÁ; Menéndez-López N; Boltes K; Castro-Puyana M; Marina ML
[Ad] Endereço:Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871 Alcalá de Henares (Madrid), Spain.
[Ti] Título:A capillary micellar electrokinetic chromatography method for the stereoselective quantitation of bioallethrin in biotic and abiotic samples.
[So] Source:J Chromatogr A;1510:108-116, 2017 Aug 11.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A capillary micellar electrokinetic chromatography (MEKC) method was developed enabling the stereoselective separation of the insecticide bioallethrin. The use of sodium deoxycholate bile salt and acetyl-ß-cyclodextrin (acetyl-ß-CD) made possible the separation of bioallethrin stereoisomers with a high enantioresolution (7.4) in a short analysis time (6.5min). The analytical characteristics of the developed method were evaluated in terms of linearity, accuracy, precision, and limits of detection (LOD) and quantitation (LOQ) showing a good performance for the quantitation of bioallethrin stereoisomers with LODs of 0.2 and 0.3mg/L. The developed method was applied to the stereoselective analysis of a commercial bioallethrin pediculicide formulation and to evaluate the toxicity of bioallethrin stereoisomers on the growth of the unicellular freshwater green alga Pseudokirchneriella subcapitata and on the germination of the higher plant Sorghum bicolor (non-target organisms). The analysis of the commercial pediculicide showed a good agreement between the contents determined for the two stereoisomers and those labelled in the commercial samples. Different toxic responses and biodegradation profiles were found for each stereoisomer in ecotoxicity assays. The mixture of S/R stereoisomers of bioallethrin resulted more toxic than S-bioallethrin for green algae, with EC50 values of 1.10±0.06 for the mixture and of 1.73±0.05mg/L for the pure S-biallethrin (esbiol). Germination of plants seeds was also affected.
[Mh] Termos MeSH primário: Aletrina/análise
Técnicas de Química Analítica/métodos
Cromatografia Capilar Eletrocinética Micelar
[Mh] Termos MeSH secundário: Aletrina/isolamento & purificação
Aletrina/toxicidade
Clorófitas/química
Clorófitas/efeitos dos fármacos
Clorófitas/crescimento & desenvolvimento
Ácido Desoxicólico/química
Germinação/efeitos dos fármacos
Inseticidas/análise
Inseticidas/isolamento & purificação
Limite de Detecção
Sorghum/química
Sorghum/efeitos dos fármacos
Estereoisomerismo
beta-Ciclodextrinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (beta-Cyclodextrins); 005990WHZZ (Deoxycholic Acid); 0X03II877M (Allethrin); G79DM7O471 (bioallethrin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


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[PMID]:28614691
[Au] Autor:Le T; Kinh NV; Cuc NTK; Tung NLN; Lam NT; Thuy PTT; Cuong DD; Phuc PTH; Vinh VH; Hanh DTH; Tam VV; Thanh NT; Thuy TP; Hang NT; Long HB; Nhan HT; Wertheim HFL; Merson L; Shikuma C; Day JN; Chau NVV; Farrar J; Thwaites G; Wolbers M; IVAP Investigators
[Ad] Endereço:From Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit (T.L., N.T.T., T.P.T., N.T.H., H.B.L., H.T.N., H.F.L.W., J.N.D., J.F., G.T., M.W.), and the Hospital for Tropical Diseases (N.T.K.C., N.L.N.T., N.V.V.C.), Ho Chi Minh City, the National Hospital for Tropical Disea
[Ti] Título:A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis.
[So] Source:N Engl J Med;376(24):2329-2340, 2017 06 15.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Talaromyces marneffei infection is a major cause of human immunodeficiency virus (HIV)-related death in South and Southeast Asia. Guidelines recommend initial treatment with amphotericin B deoxycholate, but this drug has substantial side effects, a high cost, and limited availability. Itraconazole is available in oral form, is associated with fewer unacceptable side effects than amphotericin, and is widely used in place of amphotericin; however, clinical trials comparing these two treatments are lacking. METHODS: In this open-label, noninferiority trial, we randomly assigned 440 HIV-infected adults who had talaromycosis, confirmed by either microscopy or culture, to receive either intravenous amphotericin B deoxycholate (amphotericin) (219 patients), at a dose of 0.7 to 1.0 mg per kilogram of body weight per day, or itraconazole capsules (221 patients), at a dose of 600 mg per day for 3 days, followed by 400 mg per day, for 11 days; thereafter, all the patients received maintenance therapy with itraconazole. The primary outcome was all-cause mortality at week 2. Secondary outcomes included all-cause mortality at week 24, the time to clinical resolution of talaromycosis, early fungicidal activity, relapse of talaromycosis, development of the immune reconstitution inflammatory syndrome (IRIS), and the side-effect profile. RESULTS: The risk of death at week 2 was 6.5% in the amphotericin group and 7.4% in the itraconazole group (absolute risk difference, 0.9 percentage points; 95% confidence interval [CI], -3.9 to 5.6; P<0.001 for noninferiority); however, the risk of death at week 24 was 11.3% in the amphotericin group and 21.0% in the itraconazole group (absolute risk difference, 9.7 percentage points; 95% CI, 2.8 to 16.6; P=0.006). Treatment with amphotericin was associated with significantly faster clinical resolution and fungal clearance and significantly lower rates of relapse and IRIS than itraconazole. The patients who received amphotericin had significantly higher rates of infusion-related reactions, renal failure, hypokalemia, hypomagnesemia, and anemia than patients in the itraconazole group. CONCLUSIONS: Amphotericin was superior to itraconazole as initial treatment for talaromycosis with respect to 6-month mortality, clinical response, and fungicidal activity. (Funded by the Medical Research Council and others; IVAP Current Controlled Trials number, ISRCTN59144167 .).
[Mh] Termos MeSH primário: Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico
Anfotericina B/uso terapêutico
Antifúngicos/uso terapêutico
Ácido Desoxicólico/uso terapêutico
Itraconazol/uso terapêutico
Micoses/tratamento farmacológico
Talaromyces
[Mh] Termos MeSH secundário: Infecções Oportunistas Relacionadas com a AIDS/mortalidade
Administração Oral
Adulto
Anfotericina B/efeitos adversos
Antifúngicos/efeitos adversos
Creatinina/metabolismo
Ácido Desoxicólico/efeitos adversos
Combinação de Medicamentos
Feminino
Seres Humanos
Quimioterapia de Indução/efeitos adversos
Infusões Intravenosas/efeitos adversos
Itraconazol/efeitos adversos
Masculino
Micoses/mortalidade
Talaromyces/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Drug Combinations); 005990WHZZ (Deoxycholic Acid); 304NUG5GF4 (Itraconazole); 7XU7A7DROE (Amphotericin B); 87687-70-5 (amphotericin B, deoxycholate drug combination); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1613306


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[PMID]:28522064
[Au] Autor:Kantor J
[Ad] Endereço:Department of Dermatology, Perelman School of Medicine, the University of Pennsylvania, Philadelphia, Pennsylvania; Florida Center for Dermatology, PA, Saint Augustine, Florida. Electronic address: jonkantor@gmail.com.
[Ti] Título:Synergistic effect of combination deoxycholic acid and botulinum toxin (the Bellatox technique) for the treatment of submental fullness.
[So] Source:J Am Acad Dermatol;76(6):e209-e211, 2017 06.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Toxinas Botulínicas Tipo A/uso terapêutico
Ácido Desoxicólico/uso terapêutico
Pescoço
Gordura Subcutânea/efeitos dos fármacos
[Mh] Termos MeSH secundário: Sinergismo Farmacológico
Quimioterapia Combinada
Estética
Feminino
Seguimentos
Seres Humanos
Injeções Subcutâneas
Meia-Idade
Satisfação do Paciente
Envelhecimento da Pele/efeitos dos fármacos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
005990WHZZ (Deoxycholic Acid); EC 3.4.24.69 (Botulinum Toxins, Type A)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE



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