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[PMID]:28106795
[Au] Autor:Ng F; Couture G; Philippe C; Boutevin B; Caillol S
[Ad] Endereço:Institut Charles Gerhardt-UMR 5253, CNRS, Université de Montpellier, ENSCM, 8 rue de l'Ecole Normale, 34296 Montpellier, France. feifeing.fr@gmail.com.
[Ti] Título:Bio-Based Aromatic Epoxy Monomers for Thermoset Materials.
[So] Source:Molecules;22(1), 2017 Jan 18.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The synthesis of polymers from renewable resources is a burning issue that is actively investigated. Polyepoxide networks constitute a major class of thermosetting polymers and are extensively used as coatings, electronic materials, adhesives. Owing to their outstanding mechanical and electrical properties, chemical resistance, adhesion, and minimal shrinkage after curing, they are used in structural applications as well. Most of these thermosets are industrially manufactured from bisphenol A (BPA), a substance that was initially synthesized as a chemical estrogen. The awareness on BPA toxicity combined with the limited availability and volatile cost of fossil resources and the non-recyclability of thermosets implies necessary changes in the field of epoxy networks. Thus, substitution of BPA has witnessed an increasing number of studies both from the academic and industrial sides. This review proposes to give an overview of the reported aromatic multifunctional epoxide building blocks synthesized from biomass or from molecules that could be obtained from transformed biomass. After a reminder of the main glycidylation routes and mechanisms and the recent knowledge on BPA toxicity and legal issues, this review will provide a brief description of the main natural sources of aromatic molecules. The different epoxy prepolymers will then be organized from simple, mono-aromatic di-epoxy, to mono-aromatic poly-epoxy, to di-aromatic di-epoxy compounds, and finally to derivatives possessing numerous aromatic rings and epoxy groups.
[Mh] Termos MeSH primário: Produtos Biológicos/química
Compostos de Epóxi/síntese química
Resinas Epóxi/síntese química
Polímeros/síntese química
[Mh] Termos MeSH secundário: Compostos Benzidrílicos/química
Compostos Benzidrílicos/toxicidade
Produtos Biológicos/isolamento & purificação
Biomassa
Ácidos Cafeicos/química
Ácidos Cafeicos/isolamento & purificação
Cardanolídeos/química
Cardanolídeos/isolamento & purificação
Catecóis/química
Catecóis/isolamento & purificação
Química Verde
Lignina/química
Lignina/isolamento & purificação
Fenóis/química
Fenóis/toxicidade
Taninos/química
Taninos/isolamento & purificação
Temperatura Ambiente
Terpenos/química
Terpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Biological Products); 0 (Caffeic Acids); 0 (Cardanolides); 0 (Catechols); 0 (Epoxy Compounds); 0 (Epoxy Resins); 0 (Phenols); 0 (Polymers); 0 (Tannins); 0 (Terpenes); 9005-53-2 (Lignin); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


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[PMID]:21401694
[Au] Autor:Yoshika M; Komiyama Y; Takahashi H
[Ad] Endereço:Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Osaka, Japan.
[Ti] Título:Isolation of marinobufotoxin from the supernatant of cultured PC12 cells.
[So] Source:Clin Exp Pharmacol Physiol;38(5):334-7, 2011 May.
[Is] ISSN:1440-1681
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:1. Digitalis-like factors (DLFs) are believed to be involved in sodium metabolism via inhibition of Na(+) /K(+) -ATPase and may cause hypertension. Yet, the source and regulation of secretion of DLFs remain unknown. Recently, marinobufagenin (MBG) was isolated in mammals and implicated in renal sodium and water metabolism. More recently, we isolated marinobufotoxin (MBT), a suberoyl arginine ester of MBG, in Y-1 cells. We have developed an ELISA to measure MBG-like immunoreactivity (MBG-IR) and have characterized MBG-IR using chromatography. We have also identified a ouabain-like factor in cultured PC12 cells from a phaeochromocytoma cell line. In the present study, we examined whether MBT was produced in the adrenal medulla. 2. PC12 cells were cultured in serum-free medium and culture supernatants were collected over a period of 24 h. The supernatants were analysed by ELISA and HPLC to determine MBG-IR content. The HPLC fraction containing the main peak of MBG-IR was characterized by LC/MS. 3. Compared with samples collected at 0.5 h, the concentration of MBG-IR in culture supernatants increased significantly after 2 h and continued to increase until 24 h. The fraction with the highest ELISA peak for MBG-IR had the same HPLC elution time as authentic MBT. Furthermore, tandem mass spectrometry indicated that each fraction of MBT and MBG had the correct specific daughter ions. 4. The results indicate that MBT and MBG are produced and/or secreted by adrenomedullary cells.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Suprarrenais/metabolismo
Cardanolídeos/isolamento & purificação
Meios de Cultivo Condicionados/química
Feocromocitoma/metabolismo
[Mh] Termos MeSH secundário: Neoplasias das Glândulas Suprarrenais/patologia
Animais
Cardanolídeos/metabolismo
Cromatografia Líquida de Alta Pressão
Cromatografia Líquida
Ensaio de Imunoadsorção Enzimática
Espectrometria de Massas
Células PC12
Feocromocitoma/patologia
Ratos
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cardanolides); 0 (Culture Media, Conditioned); 0 (marinobufotoxin)
[Em] Mês de entrada:1109
[Cu] Atualização por classe:110503
[Lr] Data última revisão:
110503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110316
[St] Status:MEDLINE
[do] DOI:10.1111/j.1440-1681.2011.05512.x


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[PMID]:19721255
[Au] Autor:Kasai H; Tsubuki M; Shimada K; Nambara T; Honda T
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Hoshi University, Japan. kasai@hoshi.ac.jp
[Ti] Título:Analyses of biologically active steroids: antitumor active OSW-1 and cardiotonic marinobufotoxin, by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight tandem mass spectrometry.
[So] Source:Chem Pharm Bull (Tokyo);57(9):948-56, 2009 Sep.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Naturally occurring constituents of biological or pharmaceutical interest often exist in the form of glycosides or conjugates. Mass spectral investigations of these compounds require soft ionization techniques if information on molecular mass, sugar sequence, or conjugate content is desired. In this study, matrix-assisted laser desorption/ionization (MALDI) quadrupole ion trap (QIT) time-of-flight tandem mass spectrometry (TOF-MS(n)) was used to identify both OSW-1, an acetylated cholestane diglycoside showing antitumor activity, and the cardiotonic steroid, bufotoxin. Each molecular-related ion was identified, and subsequent collision-induced dissociation experiments in which a molecular-related ion was selected as a precursor ion produced the characteristic product ions that are essential for structural elucidation. OSW-1 and its analogue with a modified side chain, thienyl OSW-1, were synthesized, and bufotoxins, i.e., marinobufotoxin and its homologue, marinobufagin 3-pimeloylarginine ester, were isolated from toad venom. On MALDI-TOF-MS, sodium-adduct [M+Na](+) ions were observed in the steroid glycosides, although protonated [M+H](+) ions were relatively more abundant than sodium-adduct [M+Na](+) ions in the bufotoxins. On the basis of tandem MS results, we propose key fragmentation pathways. The sugar moiety or side chain from the precursor ion was eliminated in OSW-1. However, characteristic product ions originating from the cleavage of the side chain with an ester formation were observed in the bufotoxins. Post-source decay (PSD) on MALDI-TOF-MS is also described when evaluating alpha-cyano-4-hydroxycinnamic acid or 2,5-dihydroxybenzoic acid as a matrix to obtain useful ions required for the identification of compound.
[Mh] Termos MeSH primário: Antineoplásicos/química
Cardanolídeos/química
Colestenonas/química
Saponinas/química
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
[Mh] Termos MeSH secundário: Venenos de Anfíbios/química
Animais
Anuros
Cardanolídeos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amphibian Venoms); 0 (Antineoplastic Agents); 0 (Cardanolides); 0 (Cholestenones); 0 (Saponins); 0 (marinobufotoxin); 145075-81-6 (OSW 1)
[Em] Mês de entrada:0912
[Cu] Atualização por classe:090901
[Lr] Data última revisão:
090901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090902
[St] Status:MEDLINE


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[PMID]:17116763
[Au] Autor:Yoshika M; Komiyama Y; Konishi M; Akizawa T; Kobayashi T; Date M; Kobatake S; Masuda M; Masaki H; Takahashi H
[Ad] Endereço:Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Fumizonocho, Moriguchi, Osaka 570-8507, Japan.
[Ti] Título:Novel digitalis-like factor, marinobufotoxin, isolated from cultured Y-1 cells, and its hypertensive effect in rats.
[So] Source:Hypertension;49(1):209-14, 2007 Jan.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Marinobufagenin and telecinobufagin have been identified as digitalis-like factors in mammals. In toads, marinobufagenin-related compounds, such as marinobufotoxin (MBT), have been isolated in some tissues but not in mammals, and its biological action has not been elucidated. Herein, we aimed to explore the possible production and/or secretion of MBT and the biological action in rats. First, the MBT in culture supernatant of the adrenocortical-originated cell line Y-1 was analyzed by high-performance liquid chromatography and sensitive ELISA for marinobufagenin-like immunoreactivity. Moreover, the structural information was obtained by mass spectrometry. To determine the biological action, MBT (9.6 and 0.96 microg/kg per day) was intraperitoneally infused via an osmotic minipump for 1 week. Blood pressure and renal excretion of marinobufagenin-like immunoreactivity were measured. Marinobufagenin-like immunoreactivity was found in Y-1 cell culture media, and the concentration increased until 24 hours. The structural analysis suggested that marinobufagenin-like immunoreactivities were marinobufagenin and MBT, and tandem mass spectrum analysis revealed them with the specific daughter ions. The highest sensitive ELISA-positive peak of marinobufagenin-like immunoreactivity in the media was MBT. Continuous administration of MBT in rats for 1 week significantly increased systolic blood pressure and renal excretion of marinobufagenin-like immunoreactivity compared with control rats (135+/-3.0 versus 126+/-2.0 mm Hg and 1.41+/-0.286 versus 0.34+/-0.064 ng/day, respectively). These data suggest that MBT, arginine-suberoyl ester of marinobufagenin, can be a novel digitalis-like factor with hypertensive action and is secreted from the adrenocortical cells.
[Mh] Termos MeSH primário: Córtex Suprarrenal/química
Cardanolídeos/isolamento & purificação
Cardenolídeos/isolamento & purificação
Hipertensão/induzido quimicamente
Saponinas/isolamento & purificação
[Mh] Termos MeSH secundário: Córtex Suprarrenal/citologia
Animais
Anticorpos Monoclonais
Especificidade de Anticorpos
Pressão Sanguínea/efeitos dos fármacos
Bufanolídeos/imunologia
Bufanolídeos/urina
Cardanolídeos/administração & dosagem
Cardanolídeos/farmacologia
Cardenolídeos/administração & dosagem
Cardenolídeos/farmacologia
Linhagem Celular
Cromatografia Líquida de Alta Pressão
Esquema de Medicação
Ensaio de Imunoadsorção Enzimática
Injeções Intraperitoneais
Masculino
Espectrometria de Massas
Ratos
Ratos Wistar
Saponinas/administração & dosagem
Saponinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Bufanolides); 0 (Cardanolides); 0 (Cardenolides); 0 (Saponins); 0 (digoxin-like factors); 0 (marinobufotoxin); 3KBT25GV2B (marinobufagenin)
[Em] Mês de entrada:0701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061123
[St] Status:MEDLINE


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[PMID]:1655495
[Au] Autor:Ebner F; Mermi J
[Ad] Endereço:Institut für Pharmakologie und Toxikologie Technischen Universität München, F.R.G.
[Ti] Título:The association with receptors regulates the Na+,K(+)-ATPase inhibitory potency of some cardioactive steroids.
[So] Source:Eur J Pharmacol;207(1):61-5, 1991 May 25.
[Is] ISSN:0014-2999
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The onset of inhibition of Na+,K(+)-ATPase from guinea-pig myocardium was quantified with pseudo-first-order rate constants in a series of 14 cardioactive steroids. From these data the association and dissociation rate constants of the steroid-receptor complex were calculated. It was then found that the association of the steroids with receptors but not the dissociation of the steroid-receptor complex determined the largely different inhibitory potencies. Consistent with this finding, at equieffective steroid concentrations the rates of inhibition varied only slightly. The correlation of the association rate with the hydrophobicity of the compounds suggests that hydrophobic interactions facilitate the access of the steroid to the receptor. A conformational transition of the vicinity of the receptor subsequent to the formation of the steroid-receptor complex seems to alter the hydrophobic properties of the receptor environment to make the dissociation rate independent from hydrophobicity.
[Mh] Termos MeSH primário: Cardanolídeos/farmacologia
Fármacos Cardiovasculares/farmacologia
Receptores de Esteroides/efeitos dos fármacos
ATPase Trocadora de Sódio-Potássio/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Fenômenos Químicos
Química Física
Cobaias
Técnicas In Vitro
Cinética
Conformação Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cardanolides); 0 (Cardiovascular Agents); 0 (Receptors, Steroid); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase)
[Em] Mês de entrada:9111
[Cu] Atualização por classe:161123
[Lr] Data última revisão:
161123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:910525
[St] Status:MEDLINE


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[PMID]:522472
[Au] Autor:Seldes AM; Gros EG
[Ti] Título:Mass spectra of steroids having a lactone-side chain.
[So] Source:J Steroid Biochem;11(5-6):1573-5, 1979 Nov-Dec.
[Is] ISSN:0022-4731
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Cardanolídeos/análise
[Mh] Termos MeSH secundário: Cardenolídeos/análise
Espectrometria de Massas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardanolides); 0 (Cardenolides)
[Em] Mês de entrada:8003
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:791101
[St] Status:MEDLINE


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[PMID]:222907
[Au] Autor:Fullerton DS; Yoshioka K; Rohrer DC; From AH; Ahmed K
[Ti] Título:Cardenolide analogues. 4. (20R)- and (20S)-Cardanolides: on the roles of the 20(22)-ene and 14beta-hydroxyl in genin activity.
[So] Source:J Med Chem;22(5):529-33, 1979 May.
[Is] ISSN:0022-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:(20R)-20,22-Dihydrodigitoxigenin (3a) and (20S)-20,22-dihydrodigitoxigenin (3b) were isolated from (20R,S)-20,22-dihydrodigitoxigenin (3) by three fractional crystallizations each from ethyl acetate. The two diastereomers have distinct NMR spectra and similar (Na+,K+)ATPase inhibitory activities (I50 = 1.1-1.4 X 10(-5) M)--about 1/100 as active as digitoxigenin (1). Their activity compared with other cardenolide analogues suggests a passive geometric role for the 20(22) double bond in eliciting (Na+,K+)ATPase inhibition, keeping the lactone carbonyl in the proper orientation. (20S)-3 beta,14 beta-Dihydroxy-22-methylene-5 beta,14 beta-cardanolide (7a) was then synthesized from 3a, and (20R)-3 beta,14 beta-dihydroxy-22-methylene-5 beta,14 beta-cardanolide (7b) from 3b. They were found to be equivalently active in inhibiting (Na+,K+)ATPase, with I50 values of 7.0 x 10(-5) M. Although it has been usually believed that the 14 beta-hydroxyl of cardenolides increases binding to the receptor, 2b (the 14-ene derivative of 7b) was more than twice as active (I50 = 3.0 X 10(-5)) than either 7a or 7b.
[Mh] Termos MeSH primário: Cardanolídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/enzimologia
Cardanolídeos/síntese química
Cardenolídeos/farmacologia
Digitoxigenina/análogos & derivados
Digitoxigenina/síntese química
Digitoxigenina/farmacologia
Técnicas In Vitro
Espectroscopia de Ressonância Magnética
Conformação Molecular
Ratos
ATPase Trocadora de Sódio-Potássio/antagonistas & inibidores
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Cardanolides); 0 (Cardenolides); 143-62-4 (Digitoxigenin); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase)
[Em] Mês de entrada:7909
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:790501
[St] Status:MEDLINE


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[PMID]:844581
[Au] Autor:Shigei T; Tsuru H; Ishikawa N
[Ti] Título:Cardiotonic activities of some new type of bufadienolide- and cardenolide-conjugates.
[So] Source:Experientia;33(2):258-60, 1977 Feb 15.
[Is] ISSN:0014-4754
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Mh] Termos MeSH primário: Bufanolídeos/farmacologia
Cardanolídeos/farmacologia
Glicosídeos Cardíacos
[Mh] Termos MeSH secundário: Animais
Anuros
Função Atrial
Bioensaio
Digitoxigenina/farmacologia
Cobaias
Coração/efeitos dos fármacos
Coração/fisiologia
Átrios do Coração/efeitos dos fármacos
Frequência Cardíaca/efeitos dos fármacos
Masculino
Ranidae
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bufanolides); 0 (Cardanolides); 0 (Cardiac Glycosides); 143-62-4 (Digitoxigenin)
[Em] Mês de entrada:7705
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:770215
[St] Status:MEDLINE


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[PMID]:1263350
[Au] Autor:Tsuru H; Shigei T
[Ti] Título:Participation of catecholamine in the digitoxigenin-induced contraction of isolated dog veins.
[So] Source:Jpn J Pharmacol;(1):120-2, 1976 Feb.
[Is] ISSN:0021-5198
[Cp] País de publicação:Japan
[La] Idioma:eng
[Mh] Termos MeSH primário: Cardanolídeos/farmacologia
Catecolaminas/fisiologia
Digitoxigenina/farmacologia
Contração Muscular/efeitos dos fármacos
Veia Porta/efeitos dos fármacos
Veia Safena/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cães
Técnicas In Vitro
Masculino
Músculo Liso/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardanolides); 0 (Catecholamines); 143-62-4 (Digitoxigenin)
[Em] Mês de entrada:7607
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:760201
[St] Status:MEDLINE


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[PMID]:1263129
[Au] Autor:Caldwell RW; Nash CB
[Ti] Título:Pharmacological studies of a new 4-aminosugar cardiac glycoside (ASI-222).
[So] Source:J Pharmacol Exp Ther;197(1):19-26, 1976 Apr.
[Is] ISSN:0022-3565
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:ASI-222,3beta-O-(4-amino-4,6-dideoxy-beta-d-galactopyranosyl) digitoxigenin, is a semi-synthetic cardiac glycoside patterned after a natural glycoside obtained from Cambodia. Effects of ASI-222 on contractile force in the isolated rabbit atria, cardiac contractile force, cardiac rate, ventricular excitability and functional refractory period in dogs, and acute toxicity in mice have been compared to those effects of ouabain. Both electrically driven and spontaneously beating atria demonstrated more rapid onset and greater maximum increases in contractile force with ASI-222 than with ouabain in equal bath concentrations. In the dog, ASI-222 increased cardiac contractile force more rapidly and at a lower cumulative dose than ouabain. Moreover, the maximum increase in contractile force obtained with ASI-222 was greater than that obtained with ouabain. The occurrence of ventricular ectopic beats was observed at a higher cumulative dose of ASI-222 than for ouabain. Also, ASI-222 produced a decrease in ventricular excitability and an increase in functional refractory period ot the ventricle. Ouabain, in the same molar dose, produced either no change or a slight increase in these parameters. Our data indicate that ASI-222 has a greater therapeutic index than ouabain. This difference may be partially explained by effects of ASI-222 on electrical properties of the heart.
[Mh] Termos MeSH primário: Aminoglicosídeos/farmacologia
Cardanolídeos/farmacologia
Glicosídeos Cardíacos/farmacologia
Digitoxigenina/farmacologia
Hemodinâmica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aminoglicosídeos/toxicidade
Animais
Glicosídeos Cardíacos/toxicidade
Digitoxigenina/análogos & derivados
Digitoxigenina/toxicidade
Átrios do Coração/efeitos dos fármacos
Frequência Cardíaca/efeitos dos fármacos
Ventrículos do Coração/efeitos dos fármacos
Técnicas In Vitro
Masculino
Camundongos
Contração Miocárdica/efeitos dos fármacos
Ouabaína/farmacologia
Coelhos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Aminoglycosides); 0 (Cardanolides); 0 (Cardiac Glycosides); 143-62-4 (Digitoxigenin); 5ACL011P69 (Ouabain)
[Em] Mês de entrada:7607
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:760401
[St] Status:MEDLINE



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