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[PMID]:28289111
[Au] Autor:Francis NA; Ridd MJ; Thomas-Jones E; Butler CC; Hood K; Shepherd V; Marwick CA; Huang C; Longo M; Wootton M; Sullivan F; CREAM Trial Management Group
[Ad] Endereço:Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, Wales francisna@cf.ac.uk.
[Ti] Título:Oral and Topical Antibiotics for Clinically Infected Eczema in Children: A Pragmatic Randomized Controlled Trial in Ambulatory Care.
[So] Source:Ann Fam Med;15(2):124-130, 2017 Mar.
[Is] ISSN:1544-1717
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Eczema may flare because of bacterial infection, but evidence supporting antibiotic treatment is of low quality. We aimed to determine the effect of oral and topical antibiotics in addition to topical emollient and corticosteroids in children with clinically infected eczema. METHODS: We employed a 3-arm, blinded, randomized controlled trial in UK ambulatory care. Children with clinical, non-severely infected eczema were randomized to receive oral and topical placebos (control), oral antibiotic (flucloxacillin) and topical placebo, or topical antibiotic (fusidic acid) and oral placebo, for 1 week. We compared Patient Oriented Eczema Measure (POEM) scores at 2 weeks using analysis of covariance (ANCOVA). RESULTS: We randomized 113 children (40 to control, 36 to oral antibiotic, and 37 to topical antibiotic). Mean (SD) baseline Patient Oriented Eczema Measure scores were 13.4 (5.1) for the control group, 14.6 (5.3) for the oral antibiotic group, and 16.9 (5.5) for the topical antibiotic group. At baseline, 104 children (93%) had 1 or more of the following findings: weeping, crusting, pustules, or painful skin. Mean (SD) POEM scores at 2 weeks were 6.2 (6.0) for control, 8.3 (7.3) for the oral antibiotic group, and 9.3 (6.2) for the topical antibiotic group. Controlling for baseline POEM score, neither oral nor topical antibiotics produced a significant difference in mean (95% CI) POEM scores (1.5 [-1.4 to 4.4] and 1.5 [-1.6 to 4.5] respectively). There were no significant differences in adverse effects and no serious adverse events. CONCLUSIONS: We found rapid resolution in response to topical steroid and emollient treatment and ruled out a clinically meaningful benefit from the addition of either oral or topical antibiotics. Children seen in ambulatory care with mild clinically infected eczema do not need treatment with antibiotics.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Eczema/tratamento farmacológico
Floxacilina/administração & dosagem
Ácido Fusídico/administração & dosagem
[Mh] Termos MeSH secundário: Administração Cutânea
Administração Oral
Corticosteroides/administração & dosagem
Assistência Ambulatorial
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Índice de Gravidade de Doença
Resultado do Tratamento
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRAGMATIC CLINICAL TRIAL
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Anti-Bacterial Agents); 43B2M34G2V (Floxacillin); 59XE10C19C (Fusidic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1370/afm.2038


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[PMID]:28062288
[Au] Autor:Zouiten A; Mehri I; Beltifa A; Ghorbel A; Sire O; Van Loco J; Abdenaceur H; Reyns T; Ben Mansour H
[Ad] Endereço:Research Unit of Analysis and Process Applied to the Environmental - APAE Higher Institute of Applied Sciences and Technology Mahdia - University of Monastir, Tunisia; Laboratory of Chemical Residues and Contaminants, Direction of Food, Medicines and Consumer Safety, Scientific Institute of Public H
[Ti] Título:Designation of pathogenic resistant bacteria in the Sparusaurata sea collected in Tunisia coastlines: Correlation with high performance liquid chromatography-tandem mass spectrometry analysis of antibiotics.
[So] Source:Microb Pathog;106:3-8, 2017 May.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vibrio is characterized by a large number of species and some of them are human pathogens causing gastro intestinal and wound infections through the ingestion or manipulation of contaminated fishes including Vibrio parahaemolyticus and Vibrio alginolyticus. In this study, we reported the phenotypic and molecular characterization of Vibrio parahaemolyticus and Vibrio alginolyticus strains isolated from wild and farm sea bream (Sparus aurata L.) along the Tunisian coast from December 2015 to April 2016. Therefore, the antibiograms indicate a difference between farmed and wild fish. Resistance against amoxicillin antibiotic appears for the bacteria isolated from wild fish, while those from aquaculture farming presented sensitivity to amoxicillin and resistance to antibiotics colistin and fusidic acid. The chloramphenicol antibiotic exhibited a high sensitivity in all isolated bacteria. In fact, traces of amoxicillin in the organs of the fish from Hergla farm were detected by UPLC-MS/MS analysis during December 2016 to April 2016. In addition, antibiotics were detected in January 2014 with high concentration of norfloxacin 2262 ng/g in fish from Hergla coast. The results obtained in this work indicated that the use and presence of antibiotics in water impacts on the occurrence of resistant bacteria and the detection of antibiotic in fish.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão/métodos
Contaminação de Alimentos/análise
Dourada/microbiologia
Alimentos Marinhos/microbiologia
Espectrometria de Massas em Tandem/métodos
Vibrioses/veterinária
[Mh] Termos MeSH secundário: Amoxicilina/farmacologia
Animais
Aquicultura
Bactérias/genética
Bactérias/isolamento & purificação
Cloranfenicol/farmacologia
Colistina/farmacologia
DNA Bacteriano
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Doenças dos Peixes/microbiologia
Pesqueiros
Ácido Fusídico/farmacologia
Testes de Sensibilidade Microbiana/métodos
Norfloxacino/farmacologia
Água do Mar/química
Água do Mar/microbiologia
Tunísia
Vibrioses/microbiologia
Vibrio alginolyticus/química
Vibrio alginolyticus/efeitos dos fármacos
Vibrio alginolyticus/genética
Vibrio alginolyticus/isolamento & purificação
Vibrio parahaemolyticus/química
Vibrio parahaemolyticus/efeitos dos fármacos
Vibrio parahaemolyticus/genética
Vibrio parahaemolyticus/isolamento & purificação
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 0 (Water Pollutants, Chemical); 59XE10C19C (Fusidic Acid); 66974FR9Q1 (Chloramphenicol); 804826J2HU (Amoxicillin); N0F8P22L1P (Norfloxacin); Z67X93HJG1 (Colistin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE


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[PMID]:28060920
[Au] Autor:Patot S; Imbert PR; Baude J; Martins Simões P; Campergue JB; Louche A; Nijland R; Bès M; Tristan A; Laurent F; Fischer A; Schrenzel J; Vandenesch F; Salcedo SP; François P; Lina G
[Ad] Endereço:CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Lyon 1, Ecole Normale Supérieure de Lyon, CNRS UMR 5308, Lyon, France.
[Ti] Título:The TIR Homologue Lies near Resistance Genes in Staphylococcus aureus, Coupling Modulation of Virulence and Antimicrobial Susceptibility.
[So] Source:PLoS Pathog;13(1):e1006092, 2017 01.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade. Here, we investigate TirS, a Staphylococcus aureus TIR mimic that is part of a novel bacterial invasion mechanism. Its ectopic expression in eukaryotic cells inhibited TLR signaling, downregulating the NF-kB pathway through inhibition of TLR2, TLR4, TLR5, and TLR9. Skin lesions induced by the S. aureus knockout tirS mutant increased in a mouse model compared with wild-type and restored strains even though the tirS-mutant and wild-type strains did not differ in bacterial load. TirS also was associated with lower neutrophil and macrophage activity, confirming a central role in virulence attenuation through local inflammatory responses. TirS invariably localizes within the staphylococcal chromosomal cassettes (SCC) containing the fusC gene for fusidic acid resistance but not always carrying the mecA gene. Of note, sub-inhibitory concentration of fusidic acid increased tirS expression. Epidemiological studies identified no link between this effector and clinical presentation but showed a selective advantage with a SCCmec element with SCC fusC/tirS. Thus, two key traits determining the success and spread of bacterial infections are linked.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Proteínas de Bactérias/imunologia
Glicoproteínas de Membrana/genética
Proteínas de Ligação às Penicilinas/genética
Receptores de Interleucina-1/genética
Staphylococcus aureus/imunologia
Staphylococcus aureus/patogenicidade
Fatores de Virulência/genética
Fatores de Virulência/imunologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Modelos Animais de Doenças
Ácido Fusídico/farmacologia
Células HEK293
Seres Humanos
Macrófagos/imunologia
Glicoproteínas de Membrana/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fator 88 de Diferenciação Mieloide/deficiência
Fator 88 de Diferenciação Mieloide/genética
Neutrófilos/imunologia
Receptores de Interleucina-1/imunologia
Transdução de Sinais/imunologia
Infecções Cutâneas Estafilocócicas/tratamento farmacológico
Infecções Cutâneas Estafilocócicas/microbiologia
Staphylococcus aureus/genética
Receptores Toll-Like/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Membrane Glycoproteins); 0 (Myd88 protein, mouse); 0 (Myeloid Differentiation Factor 88); 0 (Penicillin-Binding Proteins); 0 (Receptors, Interleukin-1); 0 (TIRAP protein, mouse); 0 (TirS protein, Staphylococcus aureus); 0 (Toll-Like Receptors); 0 (Virulence Factors); 0 (mecA protein, Staphylococcus aureus); 59XE10C19C (Fusidic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006092


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[PMID]:28012840
[Au] Autor:Espinoza-Moraga M; Singh K; Njoroge M; Kaur G; Okombo J; De Kock C; Smith PJ; Wittlin S; Chibale K
[Ad] Endereço:Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
[Ti] Título:Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.
[So] Source:Bioorg Med Chem Lett;27(3):658-661, 2017 02 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of novel fusidic acid (FA) derivatives was synthesized by replacing the carboxylic acid group with various ester and amide groups and evaluated in vitro for their antiplasmodial activity against the chloroquine-sensitive NF54 and multidrug-resistant K1 strains of the malarial parasite Plasmodium falciparum. Most of these derivatives showed a 4-49 and 5-17-fold increase in activity against NF54 and KI strains, respectively, as compared to FA and had a good selectivity index. These derivatives are stable over the incubation period and do not appear to be prodrugs of fusidic acid.
[Mh] Termos MeSH primário: Amidas/química
Ésteres/química
Ácido Fusídico/química
Ácido Fusídico/farmacologia
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Amidas/farmacologia
Antimaláricos/síntese química
Antimaláricos/química
Antimaláricos/farmacologia
Cloroquina/farmacologia
Resistência a Medicamentos/efeitos dos fármacos
Ésteres/farmacologia
Ácido Fusídico/síntese química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amides); 0 (Antimalarials); 0 (Esters); 59XE10C19C (Fusidic Acid); 886U3H6UFF (Chloroquine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161226
[St] Status:MEDLINE


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[PMID]:27604096
[Au] Autor:Xiao JH; Zhang Y; Liang GY; Liu RM; Li XG; Zhang LT; Chen DX; Zhong JJ
[Ad] Endereço:1 Centre for Translational Medicinal of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, PR China.
[Ti] Título:Synergistic antitumor efficacy of antibacterial helvolic acid from Cordyceps taii and cyclophosphamide in a tumor mouse model.
[So] Source:Exp Biol Med (Maywood);242(2):214-222, 2017 Jan.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The antibacterial agent helvolic acid, which was isolated from the active antitumor fraction of Cordyceps taii, showed potent cytotoxicity against different human cancer cells. In the present study, the in vivo antitumor effect of helvolic acid was investigated in murine sarcoma S180 tumor-bearing mice. Doses of 10 and 20 mg/kg/day helvolic acid did not exert significant antitumor activity. Interestingly, co-administration of 10 mg/kg/day helvolic acid and 20 mg/kg/day cyclophosphamide (CTX) - a well-known chemotherapy drug - showed promising antitumor activity with a growth inhibitory rate of 70.90%, which was much higher than that of CTX alone (19.5%). Furthermore, the combination markedly prolonged the survival of tumor-bearing mice. In addition, helvolic acid enhanced the immune organ index. The protein expression levels of ß-catenin, cyclin D1, and proliferating cell nuclear antigen were significantly suppressed in mice treated with 20 mg/kg/day helvolic acid and in those receiving combination therapy. Taken together, these results indicated that helvolic acid in combination with CTX showed potent in vivo synergistic antitumor efficacy, and its mechanism of action may involve the Wnt/ ß-catenin signaling pathway.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia
Ciclofosfamida/farmacologia
Ácido Fusídico/análogos & derivados
Sarcoma/tratamento farmacológico
Via de Sinalização Wnt/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Cordyceps/química
Ciclina D1/metabolismo
Modelos Animais de Doenças
Sinergismo Farmacológico
Ácido Fusídico/farmacologia
Masculino
Camundongos
Antígeno Nuclear de Célula em Proliferação/metabolismo
Proteínas Wnt/metabolismo
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Ccnd1 protein, mouse); 0 (Proliferating Cell Nuclear Antigen); 0 (Wnt Proteins); 0 (beta Catenin); 136601-57-5 (Cyclin D1); 59XE10C19C (Fusidic Acid); 8N3DW7272P (Cyclophosphamide); MZX54GS8AH (helvolic acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160909
[St] Status:MEDLINE
[do] DOI:10.1177/1535370216668051


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[PMID]:27571049
[Au] Autor:Chen D; Lin XX; Zhao Q; Xiao J; Peng SF; Xiao MF; Ouyang DS; Tan ZR; Wang YC; Peng JB; Zhang W; Chen Y
[Ad] Endereço:a Department of Clinical Pharmacology , Xiangya Hospital, Central South University , Changsha , Hunan , China.
[Ti] Título:Screening of drug metabolizing enzymes for fusidic acid and its interactions with isoform-selective substrates in vitro.
[So] Source:Xenobiotica;47(9):778-784, 2017 Sep.
[Is] ISSN:1366-5928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. Fusidic acid (FA) is widely used for the treatment of infections of sensitive osteomyelitis or skin and soft tissue caused by bacteria. However, the role of cytochrome P450s (CYPs) in the metabolism of FA is unclear. In the present study, we screened the main CYPs for the metabolism of FA and studied its interactions with isoform-selective substrates in vitro. 2. The main CYP450s were screened according to the inhibitory effect of specific inhibitors on the metabolism of FA in human liver microsomes (HLMs) or recombinant CYP isoforms. Enzyme kinetic parameters including K , K , V , and IC were calculated to determine the potential of FA to affect CYP-mediated metabolism of isoform-selective substrates. 3. FA metabolism rate was inhibited by 49.8% and 83.1% under CYP2D6, CYP3A4 selective inhibitors in HLMs. In recombinant experiment, the inhibitory effects on FA metabolism were 83.3% for CYP2D6 and 58.9% for CYP3A4, respectively. FA showed inhibition on CYP2D6 and CYP3A4 with K s of 13.9 and 38.6 µM, respectively. Other CYP isoforms including CYP1A2, CYP2A6, CYP2C9, CYP2E1, and CYP2C19 showed minimal or no effect on the metabolism of FA. 4. FA was primarily metabolized by CYP2D6 and CYP3A4 and showed a noncompetitive inhibition on CYP2D6 and a mixed competitive inhibition on CYP3A4. Drug-drug interactions between FA and other chemicals, especially with substrates of CYP2D6 and CYP3A4, are phenomena that clinicians need to be aware of and cautious about.
[Mh] Termos MeSH primário: Ácido Fusídico/metabolismo
[Mh] Termos MeSH secundário: Citocromo P-450 CYP1A2/metabolismo
Sistema Enzimático do Citocromo P-450/metabolismo
Interações Medicamentosas
Seres Humanos
Inativação Metabólica/efeitos dos fármacos
Microssomos Hepáticos/metabolismo
Isoformas de Proteínas/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protein Isoforms); 59XE10C19C (Fusidic Acid); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.14.14.1 (Cytochrome P-450 CYP1A2)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160830
[St] Status:MEDLINE
[do] DOI:10.1080/00498254.2016.1230795


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[PMID]:27228193
[Au] Autor:Abouelfetouh A; Kassem M; Naguib M; El-Nakeeb M
[Ad] Endereço:1 Department of Microbiology, Faculty of Pharmacy, Alexandria University , Alexandria, Egypt .
[Ti] Título:Investigation and Treatment of Fusidic Acid Resistance Among Methicillin-Resistant Staphylococcal Isolates from Egypt.
[So] Source:Microb Drug Resist;23(1):8-17, 2017 Jan.
[Is] ISSN:1931-8448
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methicillin resistance among staphylococci isolated from patients in northern Egypt has escalated alarmingly in the past decade. Data about the prevalence of fusidic acid (FA) resistance in Egyptian clinical isolates are limited. This work investigates the prevalence and mechanism of FA resistance among 81 methicillin-resistant staphylococcal isolates from major hospitals of Alexandria, Egypt. Some combinations for treating infections due to resistant isolates were studied. Twenty-six isolates (32.1%) were FA resistant (minimum inhibitory concentrations [MICs] = 2-1,024 µg/ml), and fusB and fusC genes coding for FA resistance were detected in 30.77% and 34.62% of the FA-resistant strains, respectively. One highly resistant isolate, S502 (MIC = 1,024 µg/ml), possessed both genes. Plasmid curing resulted in fusB loss and MIC decrease by 16-64 folds. Conjugation caused acquisition of FA resistance among susceptible isolates. Serial passages in subinhibitory FA concentrations produced mutants with increased MIC by 4-32 folds. The combination of FA with rifampin, gentamicin, or ampicillin/sulbactam, in a subinhibitory concentration, was synergistic against the isolates, including serial passage mutants, decreasing number of survivors by an average of 2-4 logs. A relatively moderate rate of FA resistance was detected in Alexandria hospitals. Combination therapy with gentamicin, rifampin, or ampicillin/sulbactam is crucial to preserve the effectiveness of FA.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Proteínas de Bactérias/genética
Ácido Fusídico/farmacologia
Regulação Bacteriana da Expressão Gênica
Resistência a Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Meticilina/farmacologia
[Mh] Termos MeSH secundário: Ampicilina/farmacologia
Proteínas de Bactérias/metabolismo
Conjugação Genética
Combinação de Medicamentos
Farmacorresistência Bacteriana Múltipla/genética
Sinergismo Farmacológico
Egito/epidemiologia
Gentamicinas/farmacologia
Seres Humanos
Staphylococcus aureus Resistente à Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/crescimento & desenvolvimento
Staphylococcus aureus Resistente à Meticilina/metabolismo
Testes de Sensibilidade Microbiana
Plasmídeos/química
Plasmídeos/metabolismo
Rifampina/farmacologia
Infecções Estafilocócicas/tratamento farmacológico
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/microbiologia
Sulbactam/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Drug Combinations); 0 (FusB protein, Staphylococcus aureus); 0 (Gentamicins); 59XE10C19C (Fusidic Acid); 7C782967RD (Ampicillin); Q91FH1328A (Methicillin); S4TF6I2330 (Sulbactam); VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160527
[St] Status:MEDLINE
[do] DOI:10.1089/mdr.2015.0336


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[PMID]:27903884
[Au] Autor:Zhu M; Dai X; Wang YP
[Ad] Endereço:State Key Laboratory of Plant and Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
[Ti] Título:Real time determination of bacterial in vivo ribosome translation elongation speed based on LacZα complementation system.
[So] Source:Nucleic Acids Res;44(20):e155, 2016 Nov 16.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bacterial growth significantly depends on protein synthesis catalyzed by ribosome. Ribosome translation elongation speed is a key factor determining the bacterial protein synthesis rate. However, existing methods for determining translation elongation speed have limited applications. Here we developed a simple and convenient method for measuring bacterial translation elongation speed based on LacZα complementation system. It enables the measurement of in vivo translation elongation speed of different individual genes. Tests related to ribosome translation elongation speed under various growth perturbations including different nutrient conditions, low temperature, a low-speed ribosome mutant, and fusidic acid treatment, were performed to quantitatively validate this method. Using this approach, we further found that nutrient starvation caused a remarkable slow-down of ribosome translation of Escherichia coli (E. coli). We also studied the dynamic change of translation elongation speed during the process of nutrient up-shift. This method will boost the quantitative understanding of bacterial ribosome translation capacity and growth.
[Mh] Termos MeSH primário: Bactérias/genética
Bactérias/metabolismo
Elongação Traducional da Cadeia Peptídica
Ribossomos/metabolismo
[Mh] Termos MeSH secundário: Ácido Fusídico/farmacologia
Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos
Ordem dos Genes
Teste de Complementação Genética
Óperon Lac
Plasmídeos/genética
Fatores de Tempo
beta-Galactosidase/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
59XE10C19C (Fusidic Acid); EC 3.2.1.23 (beta-Galactosidase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE


  9 / 1478 MEDLINE  
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[PMID]:27828633
[Au] Autor:Bessa GR; Quinto VP; Machado DC; Lipnharski C; Weber MB; Bonamigo RR; D'Azevedo PA
[Ad] Endereço:Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA - Porto Alegre (RS), Brazil.
[Ti] Título:Staphylococcus aureus resistance to topical antimicrobials in atopic dermatitis.
[So] Source:An Bras Dermatol;91(5):604-610, 2016 Sep-Oct.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Background:: Topical antimicrobial drugs are indicated for limited superficial pyodermitis treatment, although they are largely used as self-prescribed medication for a variety of inflammatory dermatoses, including atopic dermatitis. Monitoring bacterial susceptibility to these drugs is difficult, given the paucity of laboratory standardization. Objective:: To evaluate the prevalence of Staphylococcus aureus topical antimicrobial drug resistance in atopic dermatitis patients. Methods:: We conducted a cross-sectional study of children and adults diagnosed with atopic dermatitis and S. aureus colonization. We used miscellaneous literature reported breakpoints to define S. aureus resistance to mupirocin, fusidic acid, gentamicin, neomycin and bacitracin. Results:: A total of 91 patients were included and 100 S. aureus isolates were analyzed. All strains were methicillin-susceptible S. aureus. We found a low prevalence of mupirocin and fusidic acid resistance (1.1% and 5.9%, respectively), but high levels of neomycin and bacitracin resistance (42.6% and 100%, respectively). Fusidic acid resistance was associated with more severe atopic dermatitis, demonstrated by higher EASI scores (median 17.8 vs 5.7, p=.009). Our results also corroborate the literature on the absence of cross-resistance between the aminoglycosides neomycin and gentamicin. Conclusions:: Our data, in a southern Brazilian sample of AD patients, revealed a low prevalence of mupirocin and fusidic acid resistance of S. aureus atopic eczema colonizer strains. However, for neomycin and bacitracin, which are commonly used topical antimicrobial drugs in Brazil, high levels of resistance were identified. Further restrictions on the use of these antimicrobials seem necessary to keep resistance as low as possible.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Dermatite Atópica/microbiologia
Farmacorresistência Bacteriana
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Bacitracina/farmacologia
Criança
Pré-Escolar
Estudos Transversais
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão/métodos
Feminino
Ácido Fusídico/farmacologia
Gentamicinas/farmacologia
Seres Humanos
Lactente
Masculino
Mupirocina/farmacologia
Neomicina/farmacologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gentamicins); 1404-04-2 (Neomycin); 1405-87-4 (Bacitracin); 59XE10C19C (Fusidic Acid); D0GX863OA5 (Mupirocin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


  10 / 1478 MEDLINE  
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[PMID]:27814407
[Au] Autor:Fan W; Zhang Q; Song L
[Ad] Endereço:Department of Dermatology, First People's Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu Province, People's Republic of China.
[Ti] Título:An unusual case of folliculitis spinulosa decalvans.
[So] Source:Cutis;98(3):175-178, 2016 Sep.
[Is] ISSN:2326-6929
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report the case of a 24-year-old man who presented with pustules, atrophic scars, and alopecia on the scalp, along with follicular keratotic papules on the cheeks, chest, abdomen, back, lateral upper arms, thighs, and axillae, of 6 years' duration. A diagnosis of folliculitis spinulosa decalvans (FSD) was made based on the clinical manifestation and histopathological findings. Dental examination also revealed dental anomalies and a fissured tongue, which are not known to be related to FSD. We provide an overview of the characteristic findings of FSD as well as a review of previously reported cases.
[Mh] Termos MeSH primário: Alopecia/etiologia
Claritromicina/administração & dosagem
Foliculite/patologia
Ácido Fusídico/administração & dosagem
Ceratose/patologia
Metronidazol/administração & dosagem
Dermatoses do Couro Cabeludo
Tretinoína/análogos & derivados
[Mh] Termos MeSH secundário: Adulto
Anti-Infecciosos/administração & dosagem
Fármacos Dermatológicos/administração & dosagem
Diagnóstico Diferencial
Seres Humanos
Masculino
Couro Cabeludo
Dermatoses do Couro Cabeludo/complicações
Dermatoses do Couro Cabeludo/diagnóstico
Dermatoses do Couro Cabeludo/tratamento farmacológico
Dermatoses do Couro Cabeludo/patologia
Pele/patologia
Resultado do Tratamento
Tretinoína/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Dermatologic Agents); 0 (viaminate); 140QMO216E (Metronidazole); 5688UTC01R (Tretinoin); 59XE10C19C (Fusidic Acid); H1250JIK0A (Clarithromycin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE



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