Base de dados : MEDLINE Pesquisa : D04.210.500.247.222.265.165.500 [Categoria DeCS] Referências encontradas : 1639 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 28972920 [Au] Autor: Park K; Kwak IS [Ad] Endereço: Faculty of Marine Technology, Chonnam National University, Yeosu 550-749, South Korea. [Ti] Título: Disrupting effects of antibiotic sulfathiazole on developmental process during sensitive life-cycle stage of Chironomus riparius. [So] Source: Chemosphere;190:25-34, 2018 Jan. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Antibiotics in the environment are a concern due to their potential to harm humans and interrupt ecosystems. Sulfathiazole (STZ), a sulfonamide antibiotic, is commonly used in aquaculture and is typically found in aquatic ecosystems. We evaluated the ecological risk of STZ by examining biological, molecular and biochemical response in Chironomus riparius. Samples were exposed to STZ for 12, 24 and 96 h, and effects of STZ were evaluated at the molecular level by analyzing changes in gene expression related to the endocrine system, cellular stress response and enzyme activity of genes on antioxidant and detoxification pathways. STZ exposure induced significant effects on survival, growth and sex ratio of emergent adults and mouthpart deformity in C. riparius. STZ caused concentration and time-dependent toxicity in most of the selected biomarkers. STZ exposure leads to significant heat-shock response of protein genes (HSP70, HSP40, HSP90 and HSP27) and to disruption by up-regulating selected genes, including the ecdysone receptor gene, estrogen-related receptors, ultraspiracle and E74 early ecdysone-responsive gene. Furthermore, STZ induced alteration of enzyme activities on antioxidant and detoxification responses (catalase, superoxide dismutase, glutathione peroxidase and peroxidase) in C. riparius. By inducing oxidative stress, antibiotic STZ disturbs the endocrine system and produces adverse effects in growth processes of invertebrates. [Mh] Termos MeSH primário: Chironomidae/efeitos dos fármacos Expressão Gênica/efeitos dos fármacos Estágios do Ciclo de Vida/efeitos dos fármacos Sulfatiazóis/toxicidade [Mh] Termos MeSH secundário: Animais Antibacterianos/farmacologia Antibacterianos/toxicidade Chironomidae/crescimento & desenvolvimento Ecdisona/metabolismo Sistema Endócrino/efeitos dos fármacos Sistema Endócrino/metabolismo Proteínas de Choque Térmico HSP70/metabolismo Resposta ao Choque Térmico/efeitos dos fármacos Inativação Metabólica/efeitos dos fármacos Receptores de Esteroides/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (HSP70 Heat-Shock Proteins); 0 (Receptors, Steroid); 0 (Sulfathiazoles); 0 (ecdysone receptor); 3604-87-3 (Ecdysone); Y7FKS2XWQH (sulfathiazole) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171004 [St] Status: MEDLINE

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[PMID]: 28854664 [Au] Autor: Su NY; Monteagudo EJ [Ad] Endereço: Department of Entomology and Nematology, Ft. Lauderdale Research and Education Center, University of Florida, Institute of Food and Agricultural Sciences, Ft. Lauderdale, FL 33314. [Ti] Título: Hyperecdysonism in the Formosan Subterranean Termite and Eastern Subterranean Termite (Isoptera: Rhinotermitidae). [So] Source: J Econ Entomol;110(4):1736-1739, 2017 08 01. [Is] ISSN: 1938-291X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Effects of ecdysone, 20-hydroxyecdysone (20E), and an ecdysone agonist, halofenozide, were tested against the Formosan subterranean termite, Coptotermes formosanus Shiraki, and the eastern subterranean termite, Reticulitermes flavipes (Kollar), in a 12-d no choice assay. Approximately 22-26% of R. flavipes and C. formosanus exhibited symptoms of hyperecdysonism, that is, "jackknife" position, when exposed to ecdysone and 20E at 1,000 ppm, respectively. High mortalities were recorded for both termite species in ecdysone and 20E at 100 and 1,000 ppm, but only at 10,000 ppm for halofenizide. Termites are known to move back to the central nest before the onset of ecdysis, and those that ingested lethal doses of chitin synthesis inhibitors (CSIs) die near the royal pairs, which partially accounts for the success of CSI baits to eliminate subterranean termite colonies. Because ecdysteroids and their agonists induce molting in termites, incorporation of these compounds into baits could potentially achieve the same colony elimination. This study showed that lethal time (12 d) of ecdysteroids and ecdysone agonist is shorter than that of a CSI (45 d); hence, the baiting time should be reduced by more than a month when they are incorporated in termite baits. [Mh] Termos MeSH primário: Benzoatos Ecdisona Ecdisterona Hidrazinas Controle de Insetos Inseticidas Isópteros [Mh] Termos MeSH secundário: Animais Relação Dose-Resposta a Droga Muda/efeitos dos fármacos Especificidade da Espécie [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Benzoates); 0 (Hydrazines); 0 (Insecticides); 3604-87-3 (Ecdysone); 5289-74-7 (Ecdysterone); C81K20PELV (N-4-chlorobenzoyl-N'-benzoyl-N'-tert-butylhydrazine) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170901 [St] Status: MEDLINE [do] DOI: 10.1093/jee/tox178

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[PMID]: 28726107 [Au] Autor: Nikolenko JV; Krasnov AN; Mazina MY; Georgieva SG; Vorobyeva NE [Ad] Endereço: Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia. julia.v.nikolenko@gmail.com. [Ti] Título: Studying a novel ecdysone-dependent enhancer. [So] Source: Dokl Biochem Biophys;474(1):236-238, 2017 May. [Is] ISSN: 1608-3091 [Cp] País de publicação: Russia (Federation) [La] Idioma: eng [Ab] Resumo: Earlier [4], we developed a two-stage scheme of the activation of expression of the ecdysone cascade gene ftz-f1 in Drosophila melanogaster S2 cells. In the first intron of the ftz-f1 gene, we found a binding site for the transcription activator DHR3. In this work, we studied the properties of this genomic element: the change in the histone modification level at different stages of transcription activation were analyzed, and data indicating the interaction of the intron element with the promoter were obtained. Taken together, the results of this study indicate that the studied genomic element exhibits the properties of an enhancer and functions at the stage of active gene transcription. [Mh] Termos MeSH primário: Proteínas de Ligação a DNA/genética Proteínas de Drosophila/genética Ecdisona/metabolismo Elementos Facilitadores Genéticos/genética Fatores de Transcrição/genética [Mh] Termos MeSH secundário: Animais Linhagem Celular Drosophila melanogaster/citologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA-Binding Proteins); 0 (Drosophila Proteins); 0 (Transcription Factors); 0 (nuclear hormone receptor FTZ-F1, Drosophila); 3604-87-3 (Ecdysone) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170906 [Lr] Data última revisão: 170906 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170721 [St] Status: MEDLINE [do] DOI: 10.1134/S160767291703022X

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[PMID]: 28635136 [Au] Autor: Liu F; Li K; Cai W; Zhao J; Zou Y; Hua H [Ad] Endereço: Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China. [Ti] Título: Knockdown of TOR causing ovarian diapause in a genetically stable brachypterous strain of Nilaparvata lugens. [So] Source: Arch Insect Biochem Physiol;95(4), 2017 Aug. [Is] ISSN: 1520-6327 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Brown planthopper (BPH), Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), is one of the most damaging pests of rice crops. BPH is a migratory insect with a delayed ovarian development in migrants classified as reproductive diapause. The molecular mechanism of reproductive diapause remains unclear, although we suspect it might be regulated by one or more nutrient signaling pathways. The target of rapamycin (TOR) pathway regulates cell growth in response to nutritional information, which raised a hypothesis that TOR mediates BPH reproductive diapause. We used a pure brachypterous strain (BS) and a predominantly macropterous strain (MS) to investigate the roles of NlTOR in BPH reproductive diapause. We found that NlTOR is expressed from the nymphal to adult stages, with a higher expression level of NlTOR in BS adults at 1, 2, and 4 days posteclosion than in MS at the same time points. Injection of dsNlTOR into BS nymphs resulted in the termination of BPH female ovary development and the retardation of nymph development. We infer that TOR signaling functions in BPH reproductive diapause by regulating the expression of NlFoxA and NlVitellogenin. [Mh] Termos MeSH primário: Hemípteros/fisiologia RNA de Cadeia Dupla Serina-Treonina Quinases TOR/metabolismo [Mh] Termos MeSH secundário: Animais Diapausa de Inseto Ecdisona/metabolismo Feminino Proteínas de Insetos/metabolismo Masculino Ninfa/crescimento & desenvolvimento Ovário/fisiologia Vitelogeninas/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Proteins); 0 (RNA, Double-Stranded); 0 (Vitellogenins); 3604-87-3 (Ecdysone); EC 2.7.1.1 (TOR Serine-Threonine Kinases) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170622 [St] Status: MEDLINE [do] DOI: 10.1002/arch.21400

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[PMID]: 28623733 [Au] Autor: Zhang K; Pan G; Zhao Y; Hao X; Li C; Shen L; Zhang R; Su J; Cui H [Ad] Endereço: State Key Laboratory of Silkworm Genome Biology, The Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400716, China. [Ti] Título: A novel immune-related gene HDD1 of silkworm Bombyx mori is involved in bacterial response. [So] Source: Mol Immunol;88:106-115, 2017 Aug. [Is] ISSN: 1872-9142 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Insects have evolved an effective immune system to respond to various challenges. In this study, a novel immune-related gene, called BmHDD1, was first charactered in silkworm, Bombyx mori. BmHDD1 contained an ORF of 837bp and encoding a deduced protein of 278 amino acids. BmHDD1 was specifically expressed in hemocytes, and highly expressed at the molting and metamorphosis stages under normal physiological conditions. Our results suggested that BmHDD1 was mainly generated by hemocytes and secreted into hemolymph. Our results also showed that the expression level of BmHDD1 was significantly increased after 20E injection, which indicated that BmHDD1 might be regulated by ecdysone. More importantly, BmHDD1 was dramatically induced after injected with different types of PAMPs or bacteria, either in hemocytes or fat body. Those results suggested that BmHDD1 plays a role in developing and immunity system in silkworm, Bombyx mori. [Mh] Termos MeSH primário: Bactérias/imunologia Bombyx/genética Bombyx/imunologia Proteínas de Insetos/genética Proteínas de Insetos/imunologia [Mh] Termos MeSH secundário: Sequência de Aminoácidos Animais Sequência de Bases Clonagem Molecular Ecdisona/metabolismo Hemócitos/metabolismo Hemolinfa/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Proteins); 3604-87-3 (Ecdysone) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171009 [Lr] Data última revisão: 171009 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170618 [St] Status: MEDLINE

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[PMID]: 28566535 [Au] Autor: Praggastis SA; Thummel CS [Ad] Endereço: Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA. [Ti] Título: Right time, right place: the temporal regulation of developmental gene expression. [So] Source: Genes Dev;31(9):847-848, 2017 May 01. [Is] ISSN: 1549-5477 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Many studies have focused on defining the critical transcription factors that specify tissue morphogenesis and differentiation. Our understanding of how these spatial regulators are deployed in the proper temporal order, however, has remained less clear. In this issue of , Uyehara and colleagues (pp. 862-875) provide new insights into the mechanisms by which temporal and spatial regulators are coordinated to control wing development during metamorphosis. [Mh] Termos MeSH primário: Proteínas de Drosophila/genética Ecdisona [Mh] Termos MeSH secundário: Animais Drosophila/genética Drosophila melanogaster/genética Regulação da Expressão Gênica no Desenvolvimento Genes Controladores do Desenvolvimento Metamorfose Biológica/genética Fatores de Transcrição/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Drosophila Proteins); 0 (Transcription Factors); 3604-87-3 (Ecdysone) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171101 [Lr] Data última revisão: 171101 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170602 [St] Status: MEDLINE [do] DOI: 10.1101/gad.301002.117

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[PMID]: 28536147 [Au] Autor: Uyehara CM; Nystrom SL; Niederhuber MJ; Leatham-Jensen M; Ma Y; Buttitta LA; McKay DJ [Ad] Endereço: Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA. [Ti] Título: Hormone-dependent control of developmental timing through regulation of chromatin accessibility. [So] Source: Genes Dev;31(9):862-875, 2017 May 01. [Is] ISSN: 1549-5477 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Specification of tissue identity during development requires precise coordination of gene expression in both space and time. Spatially, master regulatory transcription factors are required to control tissue-specific gene expression programs. However, the mechanisms controlling how tissue-specific gene expression changes over time are less well understood. Here, we show that hormone-induced transcription factors control temporal gene expression by regulating the accessibility of DNA regulatory elements. Using the wing, we demonstrate that temporal changes in gene expression are accompanied by genome-wide changes in chromatin accessibility at temporal-specific enhancers. We also uncover a temporal cascade of transcription factors following a pulse of the steroid hormone ecdysone such that different times in wing development can be defined by distinct combinations of hormone-induced transcription factors. Finally, we show that the ecdysone-induced transcription factor E93 controls temporal identity by directly regulating chromatin accessibility across the genome. Notably, we found that E93 controls enhancer activity through three different modalities, including promoting accessibility of late-acting enhancers and decreasing accessibility of early-acting enhancers. Together, this work supports a model in which an extrinsic signal triggers an intrinsic transcription factor cascade that drives development forward in time through regulation of chromatin accessibility. [Mh] Termos MeSH primário: Cromatina/metabolismo Drosophila/crescimento & desenvolvimento Drosophila/metabolismo Ecdisona/metabolismo Regulação da Expressão Gênica no Desenvolvimento Asas de Animais/metabolismo [Mh] Termos MeSH secundário: Animais Cromatina/genética Drosophila/genética Proteínas de Drosophila/genética Proteínas de Drosophila/metabolismo Elementos Facilitadores Genéticos/genética Feminino Pupa/metabolismo Transdução de Sinais/efeitos dos fármacos Fatores de Transcrição/genética Fatores de Transcrição/metabolismo Asas de Animais/crescimento & desenvolvimento [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Chromatin); 0 (Drosophila Proteins); 0 (E93 protein, Drosophila); 0 (Transcription Factors); 3604-87-3 (Ecdysone) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171108 [Lr] Data última revisão: 171108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170525 [St] Status: MEDLINE [do] DOI: 10.1101/gad.298182.117

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[PMID]: 28526754 [Au] Autor: Strassburger K; Lorbeer FK; Lutz M; Graf F; Boutros M; Teleman AA [Ad] Endereço: German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. [Ti] Título: Oxygenation and adenosine deaminase support growth and proliferation of cultured wing imaginal discs. [So] Source: Development;144(13):2529-2538, 2017 07 01. [Is] ISSN: 1477-9129 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The wing imaginal disc has been an important model system over past decades for discovering novel biology related to development, signaling and epithelial morphogenesis. Novel experimental approaches have been enabled using a culture setup that allows cultures of wing discs. Current setups, however, are not able to sustain both growth and cell-cycle progression of wing discs We discover here a setup that requires both oxygenation of the tissue and adenosine deaminase activity in the medium, and supports both growth and proliferation of wing discs for 9 h. Nonetheless, further work will be required to extend the duration of the culturing and to enable live imaging of the cultured discs in the future. [Mh] Termos MeSH primário: Adenosina Desaminase/metabolismo Drosophila melanogaster/citologia Drosophila melanogaster/enzimologia Discos Imaginais/citologia Oxigênio/metabolismo Asas de Animais/citologia [Mh] Termos MeSH secundário: Animais Proliferação Celular Células Cultivadas Ecdisona/metabolismo Etídio/metabolismo Corpo Adiposo/citologia Corpo Adiposo/metabolismo Insulina/metabolismo Hormônios Juvenis/metabolismo Fase S [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insulin); 0 (Juvenile Hormones); 3604-87-3 (Ecdysone); EC 3.5.4.4 (Adenosine Deaminase); EN464416SI (Ethidium); S88TT14065 (Oxygen) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171126 [Lr] Data última revisão: 171126 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170521 [St] Status: MEDLINE [do] DOI: 10.1242/dev.147538

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[PMID]: 28510140 [Au] Autor: Mazina MY; Kocheryzhkina EV; Nikolenko JV; Krasnov AN; Georgieva SG; Vorobyeva NE [Ad] Endereço: Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia. [Ti] Título: Nuclear receptors EcR, Usp, E75, DHR3, and ERR regulate transcription of ecdysone cascade genes. [So] Source: Dokl Biochem Biophys;473(1):145-147, 2017 Mar. [Is] ISSN: 1608-3091 [Cp] País de publicação: Russia (Federation) [La] Idioma: eng [Ab] Resumo: We found that an increase in the expression level of E75, DHR3, and ERR increases the degree of activation of dhr3 and hr4 genes in Drosophila S2 cells. We also detected a repressing effect of these nuclear receptors on the basal transcription level of these genes. This is the first study to show the ability of nuclear receptors E75, DHR3, and ERR to function as activators or repressors depending on external conditions. We also confirmed the existence of the interaction of all studied nuclear receptors with the promoters of dhr3 and hr4 genes of the ecdysone cascade in vivo. [Mh] Termos MeSH primário: Proteínas de Drosophila/metabolismo Drosophila melanogaster/genética Drosophila melanogaster/metabolismo Ecdisona/metabolismo Receptores Citoplasmáticos e Nucleares/metabolismo Transcrição Genética [Mh] Termos MeSH secundário: Animais Linhagem Celular Proteínas de Ligação a DNA/metabolismo Regulação da Expressão Gênica Proteínas de Insetos/metabolismo Regiões Promotoras Genéticas/genética Receptores Estrogênicos/metabolismo Receptores de Esteroides/metabolismo Fatores de Transcrição/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA-Binding Proteins); 0 (Drosophila Proteins); 0 (E75 protein, insect); 0 (ERR protein, Drosophila); 0 (Hr46 protein, Drosophila); 0 (Insect Proteins); 0 (Receptors, Cytoplasmic and Nuclear); 0 (Receptors, Estrogen); 0 (Receptors, Steroid); 0 (Transcription Factors); 0 (ecdysone receptor); 0 (ultraspiracle protein, Drosophila); 3604-87-3 (Ecdysone) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171019 [Lr] Data última revisão: 171019 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170517 [St] Status: MEDLINE [do] DOI: 10.1134/S1607672917020144

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[PMID]: 28414820 [Au] Autor: Wang P; Qiu Z; Xia D; Tang S; Shen X; Zhao Q [Ad] Endereço: School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, China. [Ti] Título: Transcriptome analysis of the epidermis of the purple quail-like (q-lp) mutant of silkworm, Bombyx mori. [So] Source: PLoS One;12(4):e0175994, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A new purple quail-like (q-lp) mutant found from the plain silkworm strain 932VR has pigment dots on the epidermis similar to the pigment mutant quail (q). In addition, q-lp mutant larvae are inactive, consume little and grow slowly, with a high death rate and other developmental abnormalities. Pigmentation of the silkworm epidermis consists of melanin, ommochrome and pteridine. Silkworm development is regulated by ecdysone and juvenile hormone. In this study, we performed RNA-Seq on the epidermis of the q-lp mutant in the 4th instar during molting, with 932VR serving as the control. The results showed 515 differentially expressed genes, of which 234 were upregulated and 281 downregulated in q-lp. BLASTGO analysis indicated that the downregulated genes mainly encode protein-binding proteins, membrane components, oxidation/reduction enzymes, and proteolytic enzymes, whereas the upregulated genes largely encode cuticle structural constituents, membrane components, transport related proteins, and protein-binding proteins. Quantitative reverse transcription PCR was used to verify the accuracy of the RNA-Seq data, focusing on key genes for biosynthesis of the three pigments and chitin as well as genes encoding cuticular proteins and several related nuclear receptors, which are thought to play key roles in the q-lp mutant. We drew three conclusions based on the results: 1) melanin, ommochrome and pteridine pigments are all increased in the q-lp mutant; 2) more cuticle proteins are expressed in q-lp than in 932VR, and the number of upregulated cuticular genes is significantly greater than downregulated genes; 3) the downstream pathway regulated by ecdysone is blocked in the q-lp mutant. Our research findings lay the foundation for further research on the developmental changes responsible for the q-lp mutant. [Mh] Termos MeSH primário: Bombyx/genética Epiderme/metabolismo Codorniz/genética Transcriptoma/genética [Mh] Termos MeSH secundário: Animais Bombyx/metabolismo Ecdisona/genética Perfilação da Expressão Gênica/métodos Genes de Insetos/genética Proteínas de Insetos/genética Larva/genética Melaninas/genética Mutação/genética Fenotiazinas/metabolismo Pigmentação/genética Pteridinas/metabolismo RNA/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Insect Proteins); 0 (Melanins); 0 (Phenothiazines); 0 (Pteridines); 0 (ommochrome); 3604-87-3 (Ecdysone); 63231-63-0 (RNA) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170505 [Lr] Data última revisão: 170505 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170418 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0175994

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