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[PMID]:26390100
[Au] Autor:Vezzosi D; Tenenbaum F; Cazabat L; Tissier F; Bienvenu M; Carrasco CA; Laloi-Michelin M; Barrande G; Lefebvre H; Hiéronimus S; Tabarin A; Bertagna X; Legmann P; Vantyghem MC; Bertherat J
[Ad] Endereço:Institut National de la Santé et de la Recherche Médicale U1016 (D.V., L.C., F.T., C.A.C., X.B., J.B.), Centre Nationale de Recherche Scientifique 8104, Université Paris Descartes, Institut Cochin, Paris, 75014 France; Service d'Endocrinologie et Maladies Métaboliques, Pôle Cardio-Vasculaire et Méta
[Ti] Título:Hormonal, Radiological, NP-59 Scintigraphy, and Pathological Correlations in Patients With Cushing's Syndrome Due to Primary Pigmented Nodular Adrenocortical Disease (PPNAD).
[So] Source:J Clin Endocrinol Metab;100(11):4332-8, 2015 Nov.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent Cushing's syndrome that may occur in an isolated form or as part of Carney complex. The diagnosis of this disease can be difficult preoperatively because computed tomography (CT) scan can be normal or suggest unilateral adrenal lesion, which can impede the correct diagnosis of bilateral adrenal disease. OBJECTIVE: The aim of our study was to describe the results of preoperative imaging (adrenal [6ß-(131)I]iodomethyl-19-norcholesterol] [NP-59] scintigraphy and standard adrenal CT scan) and their correlations with clinical, pathological, and genetics investigations in patients with PPNAD. PATIENTS AND METHODS: Seventeen patients with ACTH-independent syndrome due to PPNAD were investigated with a standard adrenal CT scan and NP-59 scintigraphy. Hormonal, pathological, and genetics data were analyzed. RESULTS: Four males and 13 females (median age, 27 y) were included. PPNAD was isolated in 11 patients (with PRKAR1A mutation, n = 7; and without PRKAR1A mutation, n = 4) and was associated with extra-adrenal manifestations of Carney complex in six patients (with PRKAR1A mutation, n = 4; and without PRKAR1A mutation, n = 2). Standard adrenal CT scan revealed micronodules in 11 patients, macronodules in three patients, and was normal in three patients. All patients demonstrated bilateral adrenal radiocholesterol uptake. Adrenal uptake was asymmetrical in 10 of 17 patients (59%). Asymmetrical uptake correlated with the presence of macronodules at pathological analysis (P = .03). CONCLUSION: Standard adrenal CT scan most often reveals micronodules but there is no specific CT imaging. NP-59 scintigraphy always shows a bilateral adrenal uptake confirming the bilateral nature of the disease, but asymmetrical scintigraphic uptake can be observed in patients with macronodules.
[Mh] Termos MeSH primário: Adosterol
Síndrome de Cushing/metabolismo
Hormônios/sangue
Compostos Radiofarmacêuticos
[Mh] Termos MeSH secundário: Adolescente
Glândulas Suprarrenais/diagnóstico por imagem
Glândulas Suprarrenais/metabolismo
Adrenalectomia
Adulto
Complexo de Carney/genética
Criança
Síndrome de Cushing/diagnóstico por imagem
Síndrome de Cushing/cirurgia
Subunidade RIalfa da Proteína Quinase Dependente de AMP Cíclico/genética
Feminino
Seres Humanos
Iodo/metabolismo
Masculino
Meia-Idade
Mutação/genética
Cuidados Pré-Operatórios
Cintilografia
Glândula Tireoide/diagnóstico por imagem
Glândula Tireoide/metabolismo
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclic AMP-Dependent Protein Kinase RIalpha Subunit); 0 (Hormones); 0 (PRKAR1A protein, human); 0 (Radiopharmaceuticals); 55623-03-5 (Adosterol); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150922
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2015-2174


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[PMID]:26041277
[Au] Autor:Papierska L; Cwikla J; Rabijewski M; Glinicki P; Otto M; Kasperlik-Zaluska A
[Ad] Endereço:Department of Endocrinology, Medical Center of Postgraduate Education, CMKP, ul. Marymoncka 99, 01-809, Warsaw, Poland. lucyferysia@wp.pl.
[Ti] Título:Adrenal (131)I-6ß-iodomethylnorcholesterol scintigraphy in choosing the side for adrenalectomy in bilateral adrenal tumors with subclinical hypercortisolemia.
[So] Source:Abdom Imaging;40(7):2453-60, 2015 Oct.
[Is] ISSN:1432-0509
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Adrenal scintigraphy with 131I-6ß-iodomethylnorcholesterol is considered by several authors the gold standard for assessing tumors with subclinical hypercortisolemia. However, most of the described series consist mainly of cases with unilateral lesions. The aim of our study was to assess whether scintigraphy is useful in choosing the adrenalectomy side in the case of bilateral adrenal tumors with subclinical hypercortisolemia. METHODS: The study focused on 15 consecutive patients with benign bilateral adrenal tumors and subclinical hypercortisolemia. The scintigraphy with 131I-6ß-iodomethylnorcholesterol was performed. Fourteen patients underwent unilateral adrenalectomy; the gland with predominant uptake on scintigraphy was removed. Cortisol and ACTH concentrations were measured one and six months after surgery. Post-dexamethasone cortisolemia was assessed six months after surgery. To date, the patients have been under postoperative observation for 1-4 years. RESULTS: Four patients showed unilateral uptake of radiotracer, and nine patients showed predominant accumulation of radiotracer in one of the adrenal glands. The smaller tumor was predominant in 2 cases. Percentage of activity on the predominant side correlates positively with the difference between tumors' diameters. Unilateral uptake of radiotracer predicts long-lasting postoperative insufficiency of the second adrenal gland. Excision of predominating tumor led to cessation of hypercortisolemia in all patients. CONCLUSIONS: The corticoadrenal scintigraphy is useful in choosing the side for operation in the case of bilateral adrenal tumors with subclinical hypercortisolemia.
[Mh] Termos MeSH primário: Adosterol
Neoplasias das Glândulas Suprarrenais/complicações
Neoplasias das Glândulas Suprarrenais/diagnóstico por imagem
Adrenalectomia
Síndrome de Cushing/complicações
Radioisótopos do Iodo
[Mh] Termos MeSH secundário: Neoplasias das Glândulas Suprarrenais/cirurgia
Glândulas Suprarrenais/diagnóstico por imagem
Glândulas Suprarrenais/cirurgia
Idoso
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Cintilografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 55623-03-5 (Adosterol)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150605
[St] Status:MEDLINE
[do] DOI:10.1007/s00261-015-0452-6


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[PMID]:25223468
[Au] Autor:Kawate H; Kohno M; Matsuda Y; Akehi Y; Tanabe M; Horiuchi T; Ohnaka K; Nomura M; Yanase T; Takayanagi R
[Ad] Endereço:Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
[Ti] Título:Long-term study of subclinical Cushing's syndrome shows high prevalence of extra-adrenal malignancy in patients with functioning bilateral adrenal tumors.
[So] Source:Endocr J;61(12):1205-12, 2014.
[Is] ISSN:1348-4540
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Subclinical Cushing's syndrome (SCS) is characterized by subtle autonomous cortisol secretion from adrenal tumors without specific signs and symptoms of hypercortisolism. Patients with SCS have a high prevalence of "lifestyle-related diseases," such as hypertension, diabetes mellitus, dyslipidemia, and osteoporosis. Long-term follow-up of SCS patients is reportedly indispensable for establishing indications for surgical treatment of SCS. We performed a follow-up survey of 27 patients with SCS (median: 5.3 years) and compared those who had undergone surgical treatment (n=15) with those who had not (n=12). The mean diameter of tumors was 31 mm; 16 (59%) patients had unilateral lesions and 11 (41%) carried bilateral ones. In 67% and 60% of the treatment group, respectively, hypertension and diabetes mellitus improved. We also noticed that eight of 11 (73%) SCS patients with bilateral adrenal tumors had extra-adrenal malignancies in various tissues. Interestingly, among nine SCS patients who had malignancies, eight showed bilateral adrenal uptake in ¹³¹I-aldosterol scintigraphy. The results imply that surgical treatment can reduce cardiovascular risks in SCS patients. Screening for malignancy may be necessary in patients with bilateral adrenal tumors suspected of autonomous hypersecretion of cortisol from both sides.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Suprarrenais/cirurgia
Glândulas Suprarrenais/secreção
Adrenalectomia
Síndrome de Cushing/fisiopatologia
Hidrocortisona/secreção
Segunda Neoplasia Primária/epidemiologia
Complicações Pós-Operatórias/epidemiologia
[Mh] Termos MeSH secundário: Adosterol
Neoplasias das Glândulas Suprarrenais/sangue
Neoplasias das Glândulas Suprarrenais/patologia
Neoplasias das Glândulas Suprarrenais/fisiopatologia
Glândulas Suprarrenais/diagnóstico por imagem
Glândulas Suprarrenais/patologia
Glândulas Suprarrenais/cirurgia
Idoso
Síndrome de Cushing/etiologia
Síndrome de Cushing/prevenção & controle
Feminino
Seguimentos
Hospitais Universitários
Seres Humanos
Hidrocortisona/sangue
Radioisótopos do Iodo
Japão/epidemiologia
Masculino
Meia-Idade
Neoplasias Primárias Múltiplas/epidemiologia
Neoplasias Primárias Múltiplas/patologia
Segunda Neoplasia Primária/patologia
Complicações Pós-Operatórias/patologia
Prevalência
Cintilografia
Compostos Radiofarmacêuticos
Índice de Gravidade de Doença
Carga Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Radiopharmaceuticals); 55623-03-5 (Adosterol); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140917
[St] Status:MEDLINE
[do] DOI:10.1507/endocrj.EJ14-0155


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[PMID]:25132951
[Au] Autor:Hwang I; Chong A; Kim JB; Kim KH; Kwon D
[Ad] Endereço:Department of Urology, Chonnam National University Hospital, Gwangju, Korea.
[Ti] Título:Adrenal cortical scintigraphy for lateralization of bilateral adrenal nodules in primary aldosteronism.
[So] Source:Korean J Urol;55(8):551-3, 2014 Aug.
[Is] ISSN:2005-6745
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias do Córtex Suprarrenal/diagnóstico por imagem
Córtex Suprarrenal/diagnóstico por imagem
Adenoma Adrenocortical/diagnóstico por imagem
Hiperaldosteronismo/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adosterol
Neoplasias do Córtex Suprarrenal/patologia
Neoplasias do Córtex Suprarrenal/cirurgia
Adrenalectomia/métodos
Adenoma Adrenocortical/patologia
Adenoma Adrenocortical/cirurgia
Idoso
Aldosterona/sangue
Coleta de Amostras Sanguíneas/métodos
Seres Humanos
Masculino
Cintilografia
Compostos Radiofarmacêuticos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 4964P6T9RB (Aldosterone); 55623-03-5 (Adosterol)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140819
[St] Status:MEDLINE
[do] DOI:10.4111/kju.2014.55.8.551


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[PMID]:24525587
[Au] Autor:Lu CC; Wu VC; Wu KD; Liu KL; Lin WC; Cheng MF; Tzen KY; Yen RF; TAIPAI Study Group
[Ad] Endereço:Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, 7 Chung-Shan South Road, Taipei, Taiwan, 100, kelvinlu@ntu.edu.tw.
[Ti] Título:Prognostic value of semiquantification NP-59 SPECT/CT in primary aldosteronism patients after adrenalectomy.
[So] Source:Eur J Nucl Med Mol Imaging;41(7):1375-84, 2014 Jul.
[Is] ISSN:1619-7089
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Primary aldosteronism (PA), characterized by an excessive production of aldosterone, affects 5-13 % of patients with hypertension. Accurate strategies are needed for the timely diagnosis of PA to allow curability and prevention of excessive cardiovascular events and related damage. This study aimed to evaluate the usefulness of semiquantification of (131)I-6ß-iodomethyl-norcholesterol (NP-59) single photon emission computed tomography (SPECT)/CT in differentiating aldosterone-producing adenoma (APA) from idiopathic adrenal hyperplasia (IAH) and in predicting clinical outcomes after adrenalectomy. METHODS: We retrospectively reviewed 49 PA patients who had undergone adrenalectomy after NP-59 SPECT/CT within 1 year. A conventional visual scale (VS) and two semiquantitative parameters generated from SPECT/CT, adrenal to liver ratio (ALR) and lesion to contralateral ratio of bilateral adrenal glands (CON), with cutoff values calculated by receiver-operating characteristic (ROC) analysis, were compared with pathology results and postsurgical outcomes to determine the accuracy. RESULTS: An ALR cutoff of 1.84 and a CON cutoff of 1.15 showed an ability to distinguish adenoma from hyperplasia similar to VS (p = 0.2592 and 0.1908, respectively). An ALR cutoff of 2.28 and a CON cutoff of 1.11 yielded the highest sensitivity and specificity to predict postsurgical outcomes, and an ALR of 2.28 had an ability superior to VS (p = 0.0215), while a CON of 1.11 did not (p = 0.1015). Patients with either ALR or CON greater than the cutoff had a high probability of positive postsurgical outcomes (n = 36/38), while patients with both ALR and CON less than the cutoff had a low probability of positive postsurgical outcomes (n = 2/11). CONCLUSION: Semiquantification of NP-59 scintigraphy has an ability similar to VS in differentiating APA from IAH, but an excellent ability to predict postsurgical outcomes of adrenalectomy. An ALR or CON greater than the cutoff strongly suggests benefits from adrenalectomy, and both ALR and CON less than the cutoff implies a reduced chance of improvement in postsurgical outcome.
[Mh] Termos MeSH primário: Adosterol
Adrenalectomia
Hiperaldosteronismo/diagnóstico
Hiperaldosteronismo/cirurgia
Imagem Multimodal
Tomografia Computadorizada de Emissão de Fóton Único
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adenoma/diagnóstico por imagem
Adulto
Idoso
Diagnóstico Diferencial
Feminino
Seres Humanos
Hiperaldosteronismo/patologia
Masculino
Meia-Idade
Variações Dependentes do Observador
Prognóstico
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
55623-03-5 (Adosterol)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:170924
[Lr] Data última revisão:
170924
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140215
[St] Status:MEDLINE
[do] DOI:10.1007/s00259-014-2692-z


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[PMID]:23674720
[Au] Autor:Chen YC; Chiu JS; Tseng CE; Chen YC
[Ti] Título:Use of NP-59 SPECT/CT imaging in atypical primary aldosteronism.
[So] Source:QJM;107(3):233-4, 2014 Mar.
[Is] ISSN:1460-2393
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Adosterol
Hiperaldosteronismo/diagnóstico por imagem
Radioisótopos do Iodo
Compostos Radiofarmacêuticos
Tomografia Computadorizada de Emissão de Fóton Único/métodos
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Hipertensão/etiologia
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Radiopharmaceuticals); 55623-03-5 (Adosterol)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130516
[St] Status:MEDLINE
[do] DOI:10.1093/qjmed/hct113


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[PMID]:24235884
[Au] Autor:Chen YC; Chiu JS; Wang YF
[Ad] Endereço:Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2 Minsheng Road, Dalin Township, Chiayi County 622, Taiwan ; School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
[Ti] Título:NP-59 SPECT/CT imaging in stage 1 hypertensive and atypical primary aldosteronism: a 5-year retrospective analysis of clinicolaboratory and imaging features.
[So] Source:ScientificWorldJournal;2013:317934, 2013.
[Is] ISSN:1537-744X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We retrospectively analyzed all primary aldosteronism (PA) patients undergoing NP-59 SPECT/CT imaging with regard to their clinicolaboratory and imaging features, investigation, and outcomes. MATERIAL AND METHODS: 11 PA patients who presented to our hospital for NP-59 SPECT/CT imaging between April 2007 and March 2012 and managed here were analyzed. RESULTS: Among 11 PA patients, eight (73%) had stage 1 hypertension, three (27%) stage 2 hypertension, four (36%) normal plasma aldosterone concentration, nine (82%) nonsuppressed plasma renin activity (PRA), six (55%) normal aldosterone-renin-ratio (ARR), eight (73%) serum potassium ≧3 mEq/L, seven (64%) subclinical presentation, seven (64%) negative confirmatory testing, and four (36%) inconclusive results on CT scan and seven (64%) on planar NP-59 scan. All 11 (100%) patients had positive results on NP-59 SPECT/CT scan. Two (18%) met typical triad and nine (82%) atypical triad. Among nine atypical PA patients, three (33%) had clinical presentation, six (67%) subclinical presentation, six (67%) negative confirmatory testing, and four (44%) inconclusive results on CT scan and six (67%) on planar NP-59 scan. All patients had improved outcomes. Significant differences between typical and atypical PA existed in PRA and ARR. CONCLUSIONS: NP-59 SPECT/CT may provide diagnostic potential in stage 1 hypertensive and atypical PA.
[Mh] Termos MeSH primário: Adosterol
Hiperaldosteronismo/complicações
Hiperaldosteronismo/diagnóstico
Hipertensão/diagnóstico
Hipertensão/etiologia
Tomografia Computadorizada de Emissão de Fóton Único/métodos
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Imagem Multimodal/métodos
Compostos Radiofarmacêuticos
Reprodutibilidade dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 55623-03-5 (Adosterol)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131116
[St] Status:MEDLINE
[do] DOI:10.1155/2013/317934


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[PMID]:23865085
[Au] Autor:Spyridonidis TJ; Apostolopoulos DJ
[Ad] Endereço:Department of Nuclear Medicine, University Hospital of Patras, Rion, Patras, Greece. tspyr@med.upatras.gr
[Ti] Título:Is there a role for Nuclear Medicine in diagnosis and management of patients with primary aldosteronism?
[So] Source:Hell J Nucl Med;16(2):134-9, 2013 May-Aug.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Primary aldosteronism (PA) is the most common cause of secondary hypertension. The diagnosis of PA is of clinical importance for choosing the appropriate treatment, meaning, surgery for the unilateral disease, and inclusion of aldosterone antagonists in the antihypertensive treatment for the bilateral disease. Current diagnostic approaches showed that the prevalence of PA is much higher than previously estimated. There is still controversy regarding the true prevalence of PA in hypertensive patients. The gold standard for differentiating between unilateral and bilateral disease is the adrenal vein sampling (AVS), a method that is invasive and is performed accurately in only few dedicated centers. Non invasive methods (imaging) for discriminating the two entities are: the CT scan, MRI and iodocholesterol (NP-59) scintigraphy performed under dexamethasone suppression. But the accuracy of imaging compared to AVS is suboptimal and can result in wrong therapeutic decisions. NP-59 scintigraphy is a non-invasive functional imaging technique that reveals the adrenal cortical autonomic function and could have of incremental value over anatomical imaging. In conclusion, in previous years NP-59 scintigraphy was used infrequently, but recently with the advent of hybrid single photon emission tomography (SPET/CT) systems the interest in NP-59 scintigraphy has been renewed. Studies comparing NP-59 SPET/CT imaging with AVS are warranted in order to establish its diagnostic accuracy.
[Mh] Termos MeSH primário: Adosterol
Glândulas Suprarrenais/diagnóstico por imagem
Hiperaldosteronismo/diagnóstico por imagem
Hiperaldosteronismo/terapia
Radioisótopos do Iodo/uso terapêutico
Tomografia por Emissão de Pósitrons/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Compostos Radiofarmacêuticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Radiopharmaceuticals); 55623-03-5 (Adosterol)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130719
[St] Status:MEDLINE


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[PMID]:22228361
[Au] Autor:Chen YC; Su YC; Chiu JS; Tseng CE
[Ad] Endereço:Division of Nephrology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital and School of Medicine, Tzu Chi University, Hualien, Taiwan. chenyichun0320@yahoo.com.tw
[Ti] Título:Diagnosis of primary aldosteronism in chronic kidney disease by I-131 NP-59 SPECT/CT imaging.
[So] Source:Clin Nucl Med;37(2):e30-2, 2012 Feb.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary aldosteronism (PA) may be missed in patients with chronic kidney disease (CKD), because CKD may disturb the renin-angiotensin-aldosterone system. Adrenal vein sampling has increased risks in patients with CKD. We report the case of a 58-year-old man with CKD and suspected PA. Left adrenal aldosteronism was diagnosed by NP-59 SPECT/CT. Left adrenalectomy demonstrated adrenocortical nodular hyperplasia. Plasma aldosterone normalized and blood pressure stabilized after surgery. NP-59 SPECT/CT may be a helpful diagnostic tool for detecting and lateralizing PA in CKD patients.
[Mh] Termos MeSH primário: Adosterol
Hiperaldosteronismo/diagnóstico por imagem
Falência Renal Crônica/diagnóstico por imagem
Imagem Multimodal
Tomografia por Emissão de Pósitrons
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Seres Humanos
Hiperaldosteronismo/complicações
Radioisótopos do Iodo
Falência Renal Crônica/complicações
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 55623-03-5 (Adosterol)
[Em] Mês de entrada:1204
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120110
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0b013e3182291f81


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[PMID]:21541242
[Au] Autor:Chen YC; Su YC; Wei CK; Chiu JS; Tseng CE; Chen SJ; Wang YF
[Ad] Endereço:Division of Nephrology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, and School of Medicine, Tzu Chi University, Hualien, Taiwan.
[Ti] Título:Diagnostic value of I-131 NP-59 SPECT/CT scintigraphy in patients with subclinical or atypical features of primary aldosteronism.
[So] Source:J Biomed Biotechnol;2011:209787, 2011.
[Is] ISSN:1110-7251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Accumulating evidence has shown the adverse effect of long-term hyperaldosteronism on cardiovascular morbidity that is independent of blood pressure. However, the diagnosis of primary aldosteronism (PA) remains a challenge for patients who present with subtle or atypical features or have chronic kidney disease (CKD). SPECT/CT has proven valuable in the diagnosis of a number of conditions. The aim of this study was to determine the usefulness of I-131 NP-59 SPECT/CT in patients with atypical presentations of PA and in those with CKD. The records of 15 patients with PA were retrospectively analyzed. NP-59 SPECT/CT was able to identify adrenal lesion(s) in CKD patients with suspected PA. Patients using NP-59 SPECT/CT imaging, compared with those not performing this procedure, significantly featured nearly normal serum potassium levels, normal aldosterone-renin ratio, and smaller adrenal size on CT and pathological examination and tended to feature stage 1 hypertension and non-suppressed plasma renin activity. These findings show that noninvasive NP-59 SPECT/CT is a useful tool for diagnosis in patients with subclinical or atypical features of PA and those with CKD.
[Mh] Termos MeSH primário: Adosterol
Hiperaldosteronismo/diagnóstico por imagem
Tomografia Computadorizada de Emissão de Fóton Único
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Demografia
Feminino
Seres Humanos
Hiperaldosteronismo/patologia
Radioisótopos do Iodo
Masculino
Programas de Rastreamento
Meia-Idade
Cintilografia
Reprodutibilidade dos Testes
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 55623-03-5 (Adosterol)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110505
[St] Status:MEDLINE
[do] DOI:10.1155/2011/209787



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