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[PMID]:29367480
[Au] Autor:Mingyai S; Srikaeo K; Kettawan A; Singanusong R; Nakagawa K; Kimura F; Ito J
[Ad] Endereço:Department of Agro-Industry, Faculty of Agriculture, Natural Resources and Environment, Naresuan University.
[Ti] Título:Effects of Extraction Methods on Phytochemicals of Rice Bran Oils Produced from Colored Rice.
[So] Source:J Oleo Sci;67(2):135-142, 2018 Feb 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Rice bran oil (RBO) especially from colored rice is rich in phytochemicals and has become popular in food, cosmetic, nutraceutical and pharmaceutical applications owing to its offering health benefits. This study determined the contents of phytochemicals including oryzanols, phytosterols, tocopherols (Toc) and tocotrienols (T3) in RBOs extracted using different methods namely cold-press extraction (CPE), solvent extraction (SE) and supercritical CO extraction (SC-CO ). Two colored rice, Red Jasmine rice (RJM, red rice) and Hom-nin rice (HN, black rice), were studied in comparison with the popular Thai fragrant rice Khao Dawk Mali 105 (KDML 105, white rice). RBOs were found to be the rich source of oryzanols, phytosterols, Toc and T3. Rice varieties had a greater effect on the phytochemicals concentrations than extraction methods. HN rice showed the significantly highest concentration of all phytochemicals, followed by RJM and KDML 105 rice, indicating that colored rice contained high concentration of phytochemicals in the oil than non-colored rice. The RBO samples extracted by the CPE method had a greater concentration of the phytochemicals than those extracted by the SC-CO and SE methods, respectively. In terms of phytochemical contents, HN rice extracted using CPE method was found to be the best.
[Mh] Termos MeSH primário: Extração Líquido-Líquido/métodos
Oryza/química
Compostos Fitoquímicos/isolamento & purificação
Óleo de Farelo de Arroz/análise
[Mh] Termos MeSH secundário: Fenilpropionatos/análise
Fenilpropionatos/isolamento & purificação
Compostos Fitoquímicos/análise
Fitosteróis/análise
Fitosteróis/isolamento & purificação
Tocoferóis/análise
Tocoferóis/isolamento & purificação
Tocotrienóis/análise
Tocotrienóis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenylpropionates); 0 (Phytochemicals); 0 (Phytosterols); 0 (Tocotrienols); LZO6K1506A (Rice Bran Oil); R0ZB2556P8 (Tocopherols); SST9XCL51M (gamma-oryzanol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17122


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[PMID]:29345907
[Au] Autor:Alvarez-Sala A; López-García G; Attanzio A; Tesoriere L; Cilla A; Barberá R; Alegría A
[Ad] Endereço:Nutrition and Food Science Area, Faculty of Pharmacy, University of Valencia , Avda. Vicente Andrés Estellés s/n, Burjassot, Valencia 46100, Spain.
[Ti] Título:Effects of Plant Sterols or ß-Cryptoxanthin at Physiological Serum Concentrations on Suicidal Erythrocyte Death.
[So] Source:J Agric Food Chem;66(5):1157-1166, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The eryptotic and hemolytic effects of a phytosterol (PS) mixture (ß-sitosterol, campesterol, stigmasterol) or ß-cryptoxanthin (ß-Cx) at physiological serum concentration and their effect against oxidative stress induced by tert-butylhydroperoxide (tBOOH) (75 and 300 µM) were evaluated. ß-Cryptoxanthin produced an increase in eryptotic cells, cell volume, hemolysis, and glutathione depletion (GSH) without ROS overproduction and intracellular Ca influx. Co-incubation of both bioactive compounds protected against ß-Cx-induced eryptosis. Under tBOOH stress, PS prevented eryptosis, reducing Ca influx, ROS overproduction and GSH depletion at 75 µM, and hemolysis at both tBOOH concentrations. ß-Cryptoxanthin showed no cytoprotective effect. Co-incubation with both bioactive compounds completely prevented hemolysis and partially prevented eryptosis as well as GSH depletion induced by ß-Cx plus tBOOH. Phytosterols at physiological serum concentrations help to prevent pro-eryptotic and hemolytic effects and are promising candidate compounds for ameliorating eryptosis-associated diseases.
[Mh] Termos MeSH primário: beta-Criptoxantina/farmacologia
Eriptose/efeitos dos fármacos
Fitosteróis/farmacologia
[Mh] Termos MeSH secundário: beta-Criptoxantina/sangue
Células Cultivadas
Colesterol/análogos & derivados
Colesterol/farmacologia
Eritrócitos/química
Eritrócitos/efeitos dos fármacos
Glutationa/sangue
Hemólise/efeitos dos fármacos
Seres Humanos
Estresse Oxidativo/efeitos dos fármacos
Sitosteroides/farmacologia
Estigmasterol/farmacologia
terc-Butil Hidroperóxido/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Beta-Cryptoxanthin); 0 (Phytosterols); 0 (Sitosterols); 5L5O665639 (campesterol); 5LI01C78DD (gamma-sitosterol); 955VYL842B (tert-Butylhydroperoxide); 97C5T2UQ7J (Cholesterol); 99WUK5D0Y8 (Stigmasterol); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05575


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[PMID]:28847728
[Au] Autor:Sadava D; Kane SE
[Ad] Endereço:Department of Cancer Biology, Beckman Research Institute of the City of Hope, 1500 East Duarte Rd., Duarte, CA 91010, USA. Electronic address: dsadava@coh.org.
[Ti] Título:The effect of brassinolide, a plant steroid hormone, on drug resistant small-cell lung carcinoma cells.
[So] Source:Biochem Biophys Res Commun;493(1):783-787, 2017 Nov 04.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Small-cell lung carcinoma (SCLC) has a dismal prognosis in part because of multidrug resistance (MDR). Epibrassinolide (EB) is a steroid hormone in plants, with many physiological effects. It acts via a membrane receptor and GSK3 pathway, resulting in stabilization of a transcription factor. The parallels to the Wnt signaling pathway, which is activated in SCLC and results in increased ß-catenin, prompted investigations of the effects of EB on drug-resistant (VPA17) and drug-sensitive (H69) SCLC cells. EB was cytotoxic to both cell lines (IC = 2 µM), indicating a lack of cross-resistance in the VPA17 cell line. EB was pro-apoptotic after 24 h as measured by ELISA of BUdR-labeled DNA fragments and caspase-3 specific activity (2.5 enzyme units/mg protein vs. 0.01 units/mg protein for untreated controls). Matrigel assays showed that EB reduced the SCLC cell invasion phenotype by 80%. Pre-incubation of VPA17 cells in 1 µM EB for 96 h reversed resistance to etoposide (IC = 6.0 µM, reduced to 1.8 µM with EB) and doxorubicin (IC = 0.37 µM, reduced to 0.09 µM). Synergism between EB and chemotherapy drugs was investigated by exposure of VPA17 cells to 1:1 ratios at the respective IC values, with serial dilutions at 0.25 to 2.0 × IC and determination of the combination index (CI). EB and etoposide showed synergism (CI = 0.80 at ED50); EB and doxorubicin also showed synergism (CI = 0.65 at ED50). Incubation of SCLC cells in EB led to a time- and dose dependent reduction of ß-catenin (maximum 80% reduction). Gene expression analyses of SCLC cells showed EB incubation resulted in significant reduction in expression of ß-catenin-dependent genes that are anti-apoptotic (e.g., c-Jun, survivin), cell division-related (e.g., CCND1 cyclin, sox9), and metastasis-related (e.g., MMP7, uPAR). WIKI4, a known inhibitor of Wnt signaling, was cytotoxic to SCLC cells (IC = 0.02 µM). Synergism between EB and WIKI4 was determined by the CI method and showed antagonism (CI = 1.09 at ED50), suggesting that EB and WIKI4 act on the same pathway. Taken together, these data indicate that EB, a natural product with widespread occurrence in plants, is pharmacologically active in both drug-sensitive and drug-resistant SCLC cells and acts through the Wnt signaling pathway.
[Mh] Termos MeSH primário: Brassinosteroides/administração & dosagem
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias Pulmonares/patologia
Reguladores de Crescimento de Planta
Carcinoma de Pequenas Células do Pulmão/tratamento farmacológico
Carcinoma de Pequenas Células do Pulmão/patologia
Esteroides Heterocíclicos/administração & dosagem
[Mh] Termos MeSH secundário: Antineoplásicos/administração & dosagem
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Seres Humanos
Fitosteróis/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Brassinosteroids); 0 (Phytosterols); 0 (Plant Growth Regulators); 0 (Steroids, Heterocyclic); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


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[PMID]:28764091
[Au] Autor:Comunian TA; Chaves IE; Thomazini M; Moraes ICF; Ferro-Furtado R; de Castro IA; Favaro-Trindade CS
[Ad] Endereço:University of São Paulo, College of Animal Science and Food Engineering, Av. Duque de Caxias Norte, 225, CP 23, CEP 13535 900 Pirassununga, SP, Brazil.
[Ti] Título:Development of functional yogurt containing free and encapsulated echium oil, phytosterol and sinapic acid.
[So] Source:Food Chem;237:948-956, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The consumption of omega-3 fatty acids and phytosterol promotes the reduction of cholesterol and triacylglycerol levels. However, such compounds are susceptible to oxidation, which hampers their application. The objective of this work was to coencapsulate echium oil, phytosterols and sinapic acid (crosslinker/antioxidant), and incorporate the obtained microcapsules into yogurt. The microcapsules were evaluated for particle size, accelerated oxidation by Rancimat, and simulation of gastric/intestinal release. The yogurts were assessed for morphology, pH, titratable acidity, color, rheology and sensory analysis. The microcapsules (13-42µm) promoted protection against oil oxidation (induction time of 54.96h). The yogurt containing microcapsules, presented a pH range from 3.89 to 4.17 and titratable acidity range from 0.798 to 0.826%, with good sensorial acceptance. It was possible to apply the microcapsules in yogurt, without compromising the rheological properties and physicochemical stability of the product.
[Mh] Termos MeSH primário: Iogurte
[Mh] Termos MeSH secundário: Ácidos Cumáricos
Echium
Ácidos Graxos Ômega-3
Seres Humanos
Fitosteróis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumaric Acids); 0 (Fatty Acids, Omega-3); 0 (Phytosterols); 68A28V6010 (sinapinic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28692412
[Au] Autor:Sadek NF; Yuliana ND; Prangdimurti E; Priosoeryanto BP; Budijanto S
[Ad] Endereço:1 Department of Food Science and Technology, Bogor Agricultural University , Bogor, Indonesia .
[Ti] Título:Plant Sterol Esters in Extruded Food Model Inhibits Colon Carcinogenesis by Suppressing Inflammation and Stimulating Apoptosis.
[So] Source:J Med Food;20(7):659-666, 2017 Jul.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plant sterols in their free forms are known to inhibit colon cancer. Whether these activities persist when compounds are incorporated into processed food is not reported yet. This study aimed to test the ability of plant sterol esters (PSE) incorporated into a nonpuffed extruded food (NPE) model to inhibit colon carcinogenesis. PSE was added into NPE at four concentrations (0.0%, 0.7%, 1.4%, and 2.1%). PSE-NPE activity was tested in azoxymethane/dextran sodium sulfate-induced Balb/c mice. The groups given PSE-NPE did not show any colon tumor formation. Immunohistochemistry results revealed that the group fed with 1.4% PSE had the lowest histoscore for cyclooxygenase-2 expression and the highest histoscore for cleaved caspase-3, cleaved caspase-8, and cleaved caspase-9expressions. The results of this study indicated that even after incorporation into a food system, which is processed using high pressure and temperature, PSE retained its chemopreventive activity. The proposed mechanisms are by suppressing inflammation and inducing apoptosis.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Neoplasias do Colo/tratamento farmacológico
Neoplasias do Colo/imunologia
Fitosteróis/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Caspase 3/genética
Caspase 3/imunologia
Caspase 8/genética
Caspase 8/imunologia
Colo/efeitos dos fármacos
Colo/imunologia
Neoplasias do Colo/genética
Neoplasias do Colo/fisiopatologia
Ciclo-Oxigenase 2/genética
Ciclo-Oxigenase 2/imunologia
Ésteres/administração & dosagem
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Esters); 0 (Phytosterols); EC 1.14.99.1 (Cyclooxygenase 2); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 8)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.3876


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[PMID]:28625503
[Au] Autor:Othman RA; Myrie SB; Mymin D; Roullet JB; DeBarber AE; Steiner RD; Jones PJH
[Ad] Endereço:Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada.
[Ti] Título:Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe.
[So] Source:J Pediatr;188:198-204.e1, 2017 Sep.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To assess the association between biomarkers of thyroid status and 5α-stanols in patients with sitosterolemia treated with ezetimibe (EZE). STUDY DESIGN: Eight patients with sitosterolemia (16-56 years of age) were studied during 14 weeks off EZE therapy and 14 weeks on EZE (10 mg/day). Serum thyroid biomarkers (free triiodothyronine [FT3], free thyroxine [FT4], FT3/FT4 ratio, thyroid-stimulating hormone), 5α-stanols (sitostanol and cholestanol), and cholestanol precursors (total cholesterol and its synthesis marker lathosterol, and 7α-hydroxy-4-cholesten-3-one cholestenol) were measured at baseline and during the 14 weeks off EZE and on EZE. RESULTS: EZE increased FT3/FT4 (10% ± 4%; P = .02). EZE reduced plasma and red blood cells sitostanol (-38% ± 6% and -20% ± 4%; all P < .05) and cholestanol (-18% ± 6% and -13% ± 3%; all P < .05). The change in plasma cholestanol level on EZE inversely correlated with the change in FT3/FT4 (r = -0.86; P = .01). EZE lowered total cholesterol (P < .0001) and did not affect 7α-hydroxy-4-cholesten-3-one cholestanol. EZE increased (P < .0001) lathosterol initially, but the level was not sustained, resulting in similar levels at week 14 off EZE and on EZE. CONCLUSION: In patients with STSL, 5α-stanols levels might be associated with thyroid function. EZE reduces circulating 5α-stanols while increasing FT3/FT4, implying increased conversion of T4 to T3, thus possibly improving thyroid hormone status. TRIAL REGISTRATION: ClinicalTrials.govNCT01584206.
[Mh] Termos MeSH primário: Anticolesterolemiantes/uso terapêutico
Ezetimiba/uso terapêutico
Hipercolesterolemia/sangue
Hipercolesterolemia/tratamento farmacológico
Enteropatias/sangue
Enteropatias/tratamento farmacológico
Erros Inatos do Metabolismo Lipídico/sangue
Erros Inatos do Metabolismo Lipídico/tratamento farmacológico
Fitosteróis/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Colestanol/sangue
Colestenonas/sangue
Colesterol/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Fitosteróis/sangue
Sitosteroides/sangue
Tireotropina/sangue
Tiroxina/sangue
Tri-Iodotironina/sangue
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticholesteremic Agents); 0 (Cholestenones); 0 (Phytosterols); 0 (Sitosterols); 06LU7C9H1V (Triiodothyronine); 3862-25-7 (7 alpha-hydroxy-4-cholesten-3-one); 80-99-9 (lathosterol); 8M308U816E (Cholestanol); 9002-71-5 (Thyrotropin); 97C5T2UQ7J (Cholesterol); C2NJ9WO6O7 (stigmastanol); EOR26LQQ24 (Ezetimibe); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


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[PMID]:28554842
[Au] Autor:Abdelkareem A; Thagun C; Nakayasu M; Mizutani M; Hashimoto T; Shoji T
[Ad] Endereço:Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama 8916-5, Ikoma, 630-0101, Nara, Japan; Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt. Electronic address: a-aboegala@bs.naist.jp.
[Ti] Título:Jasmonate-induced biosynthesis of steroidal glycoalkaloids depends on COI1 proteins in tomato.
[So] Source:Biochem Biophys Res Commun;489(2):206-210, 2017 Jul 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In tomato, perception of jasmonates by a receptor complex, which includes the F-box protein CORONATINE INSENSITIVE 1 (COI1), elicits biosynthesis of defensive steroidal glycoalkaloids (SGAs) via a jasmonate-responsive ERF transcription factor, JRE4/GAME9. Although JRE4 is upregulated by jasmonate and induces the expression of many metabolic genes involved in SGA biosynthesis, it is not known whether JRE4 alone is sufficient for increased SGA biosynthesis upon activation of jasmonate signaling. Here, we show that application of methyl jasmonate induces the expression of JRE4 and SGA biosynthesis genes in leaves and hairy roots of wild-type tomato, but not in jasmonic acid insensitive 1 (jai1), a loss-of-function mutant allele of the tomato COI1 gene. Induced overexpression of JRE4 increased the expression of SGA biosynthesis genes in transgenic hairy roots of both wild-type tomato and the jai1 mutant, suggesting that JRE4 is the primary transcription factor that functions downstream of the jasmonate signaling pathway.
[Mh] Termos MeSH primário: Alcaloides/biossíntese
Ciclopentanos/farmacologia
Lycopersicon esculentum/efeitos dos fármacos
Lycopersicon esculentum/metabolismo
Oxilipinas/farmacologia
Fitosteróis/biossíntese
Proteínas de Plantas/metabolismo
[Mh] Termos MeSH secundário: Alcaloides/química
Ciclopentanos/administração & dosagem
Oxilipinas/administração & dosagem
Fitosteróis/química
Proteínas de Plantas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Cyclopentanes); 0 (Oxylipins); 0 (Phytosterols); 0 (Plant Proteins); 6RI5N05OWW (jasmonic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


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[PMID]:28480411
[Au] Autor:Shah G; Baghel US
[Ad] Endereço:Research Scholar, IKG Punjab Technical University, Kapurthala, Punjab, India.
[Ti] Título:PHARMACOGNOSTIC STANDARDIZATION OF THE LEAF OF (MAIDEN & BETCHE) CHEEL.
[So] Source:Afr J Tradit Complement Altern Med;14(3):1-11, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: (Myrtaceae) is a well-known, commonly used, tall shrub plant in Ayurvedic medicine. Traditionally, it is used for its antimicrobial potential to treat cutaneous infections. No attempts have been made regarding pharmacognostic investigation of the plant till date. So, the present study was aimed to establish standards with the help of different pharmacognostic parameters. METHODS: Various pharmacognostic parameters (morphological, microscopic, physicochemical evaluations and preliminary phytochemical screening) were studied along with fluorescent and thin layer chromatographic analysis of the extract. RESULT: Morphologically is a shrub having height of 7 m with layered and papery bark. Leaves have an arranged pattern, petiole is 1 mm in length; linear-acute with dimensions of 10-35 mm x 1 mm. Organoleptic features shows that leaves have characteristic odour and astringent taste. The transverse section of the leaf reveals the existence of epidermal layers, mesophyll tissues, vascular bundles and secretory cavities. The stomata are anomocytic and leaf constants such as stomatal number is 180-200-225, stomatal index is 3.8-4.4-5.9, vein islet number is 18.68 (average), veinlet termination number 20.3 (average) and palisade ratio is 5.5-6.4-6.9. The results of phytochemical screening showed the occurrence of different phytoconstituents (flavonoids, phenolic tannins, phytosterol and terpenoids). CONCLUSION: The present study evaluated various pharmacognostic parameters which will help in quality control (standardization) of leaves in crude form, in herbal formulation and also aid in the preparation of an herbal monograph for the species.
[Mh] Termos MeSH primário: Anti-Infecciosos/análise
Melaleuca/química
Compostos Fitoquímicos/análise
Extratos Vegetais/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/farmacologia
Flavonoides/análise
Medicina Ayurvédica
Melaleuca/anatomia & histologia
Compostos Fitoquímicos/farmacologia
Fitosteróis/análise
Extratos Vegetais/farmacologia
Folhas de Planta/anatomia & histologia
Taninos/análise
Terpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Flavonoids); 0 (Phytochemicals); 0 (Phytosterols); 0 (Plant Extracts); 0 (Tannins); 0 (Terpenes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i3.1


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[PMID]:28426249
[Au] Autor:Klouda J; Barek J; Nesmerák K; Schwarzová-Pecková K
[Ad] Endereço:a Faculty of Science, Department of Analytical Chemistry , Charles University, UNESCO Laboratory of Environmental Electrochemistry , Prague , Czech Republic.
[Ti] Título:Non-Enzymatic Electrochemistry in Characterization and Analysis of Steroid Compounds.
[So] Source:Crit Rev Anal Chem;47(5):384-404, 2017 Sep 03.
[Is] ISSN:1547-6510
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This review summarizes achievements in electrochemistry-related research of steroid-based compounds in clinical, pharmaceutical, and environmental analysis. Special attention is paid to compounds possessing none or only isolated double bonds at the steroid core. Their direct redox activity is limited to far positive/negative potentials under variety of conditions and electrode materials and relies on the functional groups attached to the steroid skeleton, or as the case may be its double bond or moieties present at the side chain. The possibilities of electroanalytical methods in sterol characterization and analysis are demonstrated in a table with 31 references devoted to direct voltammetric and amperometric methods of oxidation of cholesterol, phytosterols, oxysterols, and related compounds at carbon-based and metal-based nanoparticles modified electrodes, and the reduction of bile acids and their conjugates at mercury-based electrodes, and modified glassy carbon electrodes. Furthermore, methods based on the indirect oxidation of cholesterol using bromine species as a mediator at platinum electrode and non-enzymatic cholesterol biosensors are reviewed. Their drawbacks and benefits are discussed with respect to the challenging task of identification and quantitation of these compounds in biological matrices, otherwise mostly performed using expensive mass spectrometric techniques preceded by a chromatographic separation step.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/métodos
Técnicas Eletroquímicas/métodos
Esteroides/análise
[Mh] Termos MeSH secundário: Animais
Ácidos e Sais Biliares/análise
Técnicas Biossensoriais/instrumentação
Colesterol/análise
Técnicas Eletroquímicas/instrumentação
Seres Humanos
Oxirredução
Fitosteróis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Bile Acids and Salts); 0 (Phytosterols); 0 (Steroids); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1080/10408347.2017.1318694


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[PMID]:28382872
[Au] Autor:Huang J; Xu M; Fang YJ; Lu MS; Pan ZZ; Huang WQ; Chen YM; Zhang CX
[Ad] Endereço:1Department of Medical Statistics and Epidemiology,School of Public Health,Sun Yat-sen University,Guangzhou 510080,People's Republic of China.
[Ti] Título:Association between phytosterol intake and colorectal cancer risk: a case-control study.
[So] Source:Br J Nutr;117(6):839-850, 2017 Mar.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A study in rodent models showed that phytosterols protected against colon carcinogenesis, probably by inhibiting dysregulated cell cycle progression and inducing cellular apoptosis. However, epidemiological studies on the relationship between phytosterols and colorectal cancer risk are quite limited. The aim of this study was to investigate dietary phytosterol intake in relation to colorectal cancer risk in the Chinese population. A case-control study was conducted from July 2010 to June 2016, recruiting 1802 eligible colorectal cancer cases plus 1813 age (5-year interval) and sex frequency-matched controls. Dietary information was collected by using a validated FFQ. The OR and 95 % CI of colorectal cancer risk were assessed by multivariable logistic regression models. A higher total intake of phytosterols was found to be associated with a 50 % reduction in colorectal cancer risk. After adjusting for various confounders, the OR of the highest quartile intake compared with the lowest quartile intake was 0·50 (95 % CI 0·41, 0·61, P trend<0·01) for total phytosterols. An inverse association was also found between the consumption of ß-sitosterol, campesterol, campestanol and colorectal cancer risk. However, stigmasterol intake was related to an increased risk of colorectal cancer. No statistically significant association was found between ß-sitostanol and colorectal cancer risk. Stratified analysis by sex showed that the positive association of stigmasterol intake with colorectal cancer risk was found only in women. These data indicated that the consumption of total phytosterols, ß-sitosterol, campesterol and campestanol is inversely associated with colorectal cancer risk in a Chinese population.
[Mh] Termos MeSH primário: Neoplasias Colorretais/prevenção & controle
Dieta
Comportamento Alimentar
Fitosteróis/uso terapêutico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
China
Ingestão de Energia
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Razão de Chances
Fitosteróis/farmacologia
Extratos Vegetais/farmacologia
Risco
Fatores Sexuais
Sitosteroides/farmacologia
Sitosteroides/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytosterols); 0 (Plant Extracts); 0 (Sitosterols); 5J08LF99N1 (campestanol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517000617



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