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[PMID]:28762499
[Au] Autor:Kaewsuksai P; Jitsurong S
[Ad] Endereço:Department of Obstetrics and Gynecology, Songkhla Hospital, Songkhla, Thailand.
[Ti] Título:Prospective study of the feasibility and effectiveness of a second-trimester quadruple test for Down syndrome in Thailand.
[So] Source:Int J Gynaecol Obstet;139(2):217-221, 2017 Nov.
[Is] ISSN:1879-3479
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the feasibility and effectiveness of a quadruple test for Down syndrome in the second trimester of pregnancy in clinical settings in Thailand. METHODS: From October 2015 to September 2016, a prospective study was undertaken in 19 hospitals in Songkhla province, Thailand. Women with a singleton pregnancy of 14-18 weeks were enrolled and underwent the quadruple test. The risk cutoff value was set at 1:250. All women with a positive test (risk ≥1:250) were offered amniocentesis. Women were followed up until delivery. RESULTS: Among 2375 women, 206 (8.7%) had a positive quadruple test; 98 (47.6%) of these women voluntarily underwent amniocentesis. Overall, seven pregnancies were complicated with chromosomal abnormalities (2.9 cases in 1000), including four cases of Down syndrome (1.7 in 1000) and three of other abnormalities. The detection, false-positive, and accuracy rates of the quadruple test for Down syndrome were 75.0%, 8.6%, and 91.4%, respectively. CONCLUSION: The quadruple test was found to be a feasible and efficient method for screening for Down syndrome in the second trimester of pregnancy in a Thai clinical setting. The test should be performed for pregnant women before an invasive test for Down syndrome.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Síndrome de Down/diagnóstico
Diagnóstico Pré-Natal
[Mh] Termos MeSH secundário: Adulto
Gonadotropina Coriônica/sangue
Síndrome de Down/sangue
Estriol/sangue
Feminino
Seres Humanos
Inibinas/sangue
Valor Preditivo dos Testes
Gravidez
Segundo Trimestre da Gravidez
Estudos Prospectivos
Tailândia
alfa-Fetoproteínas
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Chorionic Gonadotropin); 0 (alpha-Fetoproteins); 0 (inhibin A); 57285-09-3 (Inhibins); FB33469R8E (Estriol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1002/ijgo.12290


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[PMID]:28672726
[Au] Autor:Ramírez-Sánchez IM; Tuberty S; Hambourger M; Bandala ER
[Ad] Endereço:Universidad de las Américas Puebla, Sta. Catarina Mártir, Cholula, Puebla, 72810, Mexico.
[Ti] Título:Resource efficiency analysis for photocatalytic degradation and mineralization of estriol using TiO nanoparticles.
[So] Source:Chemosphere;184:1270-1285, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A resource efficiency analysis was developed that evaluated photocatalyst loading and temperature inputs, and assessed hydroxyl radical (OH) production. Catalyst loading (Aeroxide TiO P25) between 1 and 1500 mg L and temperatures between 5 and 50 °C were analyzed as input resources for OH production. After, the best experimental conditions were used to degrade and mineralize estriol (E3). The analysis showed that a low catalyst concentration lead to poor absorption of radiation and a slow reaction. When high catalyst concentrations were tested, most of the radiation was absorbed, which produced results near the top of the slowing rate of OH generation. Temperature was found a relevant resource for increasing interfacial transfer to facilitate OH production following the Arrhenius model. Two indices to measure resource efficiency were proposed: 1) the OH generation index (OHI) and 2) the initial degradation efficiency (IDE). OHI was used to measure the efficiency of a catalyst using photonic flux to generate OH production. IDE evaluated the relationship between the photocatalytic reactor set-up, catalyst, and E3 degradation. It was observed that 1.18 OH was produced when a photon interacts with a photocatalyst particle when a load of 5 mg L of photocatalyst is used at 20 °C. It was found that at initial time, 2.4 OH was generated in the systems to produce a degradation of one E3 molecule when using a photocatalyst load of 20 mg L at 20 °C. Additionally, it was demonstrated that E3 mineralization was feasible under different catalyst loading scenarios.
[Mh] Termos MeSH primário: Estriol/química
Nanopartículas/química
Processos Fotoquímicos
Titânio/química
[Mh] Termos MeSH secundário: Catálise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium); FB33469R8E (Estriol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


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[PMID]:28667415
[Au] Autor:Olatunji OS; Fatoki OS; Opeolu BO; Ximba BJ; Chitongo R
[Ad] Endereço:Department of Chemistry, Faculty of Applied Sciences, Cape Peninsula University of Technology, Cape Town, South Africa. snf_olatunji@ymail.com.
[Ti] Título:Determination of selected steroid hormones in some surface water around animal farms in Cape Town using HPLC-DAD.
[So] Source:Environ Monit Assess;189(7):363, 2017 Jul.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, a method for the simultaneous determination of two steroid hormones, 17ß-estradiol (E2) and estriol (E3), and a hormone mimicking polycarbonate, bisphenol-A (BPA), was developed and validated. This was thereafter used for the determination of the levels of the hormones in surface water collected around some livestock farms. The sensitivity of the method allowed the LODs and LOQs of the hormones and mimic hormone in the range 1.14-2.510 and 3.42-7.53 µg/L, respectively. The results revealed wide variability in the concentrations of E2 and E3, while BPA was not detected at any of the sampling stations. The concentration of E3 ranged between <1.14 and 45.5 µg/L (N = 120) in station 2 water. The highest concentration of E2 (15.7 µg/L, N = 80) was observed in water from station 1. The varied concentrations may be connected with the nature and sources of release, inconsistencies in analyte distribution due to dynamics of water flow pattern and the physical/chemical properties of the receiving water bodies.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Fazendas
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Animais
Compostos Benzidrílicos/análise
Cromatografia Líquida de Alta Pressão
Estradiol/análise
Estriol/análise
Água Doce/química
Fenóis/análise
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Phenols); 0 (Water Pollutants, Chemical); 4TI98Z838E (Estradiol); FB33469R8E (Estriol); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170702
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6070-8


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[PMID]:28342046
[Au] Autor:Ting YF; Praveena SM
[Ad] Endereço:Department of Environmental and Occupational Health, Faculty Of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Serdang, Selangor Darul Ehsan, Malaysia.
[Ti] Título:Sources, mechanisms, and fate of steroid estrogens in wastewater treatment plants: a mini review.
[So] Source:Environ Monit Assess;189(4):178, 2017 Apr.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Steroid estrogens, such as estrone (E ), 17ß-estradiol (E ), estriol (E ), and 17α-ethinylestradiol (EE ), are natural and synthetic hormones released into the environment through incomplete sewage discharge. This review focuses on the sources of steroid estrogens in wastewater treatment plants (WWTPs). The mechanisms and fate of steroid estrogens throughout the entire wastewater treatment system are also discussed, and relevant information on regulatory aspects is given. Municipal, pharmaceutical industry, and hospitals are the main sources of steroid estrogens that enter WWTPs. A typical WWTP comprises primary, secondary, and tertiary treatment units. Sorption and biodegradation are the main mechanisms for removal of steroid estrogens from WWTPs. The fate of steroid estrogens in WWTPs depends on the types of wastewater treatment systems. Steroid estrogens in the primary treatment unit are removed by sorption onto primary sludge, followed by sorption onto micro-flocs and biodegradation by microbes in the secondary treatment unit. Tertiary treatment employs nitrification, chlorination, or UV disinfection to improve the quality of the secondary effluent. Activated sludge treatment systems for steroid estrogens exhibit a removal efficiency of up to 100%, which is higher than that of the trickling filter treatment system (up to 75%). Moreover, the removal efficiency of advance treatment systems exceeds 90%. Regulatory aspects related to steroid estrogens are established, especially in the European Union. Japan is the only Asian country that implements a screening program and is actively involved in endocrine disruptor testing and assessment. This review improves our understanding of steroid estrogens in WWTPs, proposes main areas to be improved, and provides current knowledge on steroid estrogens in WWTPs for sustainable development.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Estrogênios/análise
Eliminação de Resíduos Líquidos/métodos
Águas Residuais/estatística & dados numéricos
Poluentes Químicos da Água/análise
Poluição Química da Água/estatística & dados numéricos
[Mh] Termos MeSH secundário: Ásia
Biodegradação Ambiental
Disruptores Endócrinos/análise
Estradiol/análise
Estriol
Estrona/análise
Etinilestradiol/análise
Japão
Esgotos/análise
Águas Residuais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Estrogens); 0 (Sewage); 0 (Waste Water); 0 (Water Pollutants, Chemical); 2DI9HA706A (Estrone); 423D2T571U (Ethinyl Estradiol); 4TI98Z838E (Estradiol); FB33469R8E (Estriol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170326
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-5890-x


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[PMID]:28295159
[Au] Autor:Alldred SK; Takwoingi Y; Guo B; Pennant M; Deeks JJ; Neilson JP; Alfirevic Z
[Ad] Endereço:Department of Women's and Children's Health, The University of Liverpool, First Floor, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, UK, L8 7SS.
[Ti] Título:First and second trimester serum tests with and without first trimester ultrasound tests for Down's syndrome screening.
[So] Source:Cochrane Database Syst Rev;3:CD012599, 2017 Mar 15.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Down's syndrome occurs when a person has three copies of chromosome 21 (or the specific area of chromosome 21 implicated in causing Down's syndrome) rather than two. It is the commonest congenital cause of mental disability. Non-invasive screening based on biochemical analysis of maternal serum or urine, or fetal ultrasound measurements, allows estimates of the risk of a pregnancy being affected and provides information to guide decisions about definitive testing.  Before agreeing to screening tests, parents need to be fully informed about the risks, benefits and possible consequences of such a test. This includes subsequent choices for further tests they may face, and the implications of both false positive (i.e. invasive diagnostic testing, and the possibility that a miscarried fetus may be chromosomally normal) and false negative screening tests (i.e. a fetus with Down's syndrome will be missed). The decisions that may be faced by expectant parents inevitably engender a high level of anxiety at all stages of the screening process, and the outcomes of screening can be associated with considerable physical and psychological morbidity. No screening test can predict the severity of problems a person with Down's syndrome will have. OBJECTIVES: To estimate and compare the accuracy of first and second trimester serum markers with and without first trimester ultrasound markers for the detection of Down's syndrome in the antenatal period, as combinations of markers. SEARCH METHODS: We conducted a sensitive and comprehensive literature search of MEDLINE (1980 to 25 August 2011), Embase (1980 to 25 August 2011), BIOSIS via EDINA (1985 to 25 August 2011), CINAHL via OVID (1982 to 25 August 2011), the Database of Abstracts of Reviews of Effectiveness (the Cochrane Library 25 August 2011), MEDION (25 August 2011), the Database of Systematic Reviews and Meta-Analyses in Laboratory Medicine (25 August 2011), the National Research Register (Archived 2007), and Health Services Research Projects in Progress database (25 August 2011). We did not apply a diagnostic test search filter. We did forward citation searching in ISI citation indices, Google Scholar and PubMed 'related articles'. We also searched reference lists of retrieved articles SELECTION CRITERIA: Studies evaluating tests of combining first and second trimester maternal serum markers in women up to 24 weeks of gestation for Down's syndrome, with or without first trimester ultrasound markers, compared with a reference standard, either chromosomal verification or macroscopic postnatal inspection. DATA COLLECTION AND ANALYSIS: Data were extracted as test positive/test negative results for Down's and non-Down's pregnancies allowing estimation of detection rates (sensitivity) and false positive rates (1-specificity). We performed quality assessment according to QUADAS criteria. We used hierarchical summary ROC meta-analytical methods to analyse test performance and compare test accuracy. Analysis of studies allowing direct comparison between tests was undertaken. We investigated the impact of maternal age on test performance in subgroup analyses. MAIN RESULTS: Twenty-two studies (reported in 25 publications) involving 228,615 pregnancies (including 1067 with Down's syndrome) were included. Studies were generally high quality, although differential verification was common with invasive testing of only high risk pregnancies. Ten studies made direct comparisons between tests. Thirty-two different test combinations were evaluated formed from combinations of eight different tests and maternal age; first trimester nuchal translucency (NT) and the serum markers AFP, uE3, total hCG, free ßhCG, Inhibin A, PAPP-A and ADAM 12. We looked at tests combining first and second trimester markers with or without ultrasound as complete tests, and we also examined stepwise and contingent strategies.Meta-analysis of the six most frequently evaluated test combinations showed that a test strategy involving maternal age and a combination of first trimester NT and PAPP-A, and second trimester total hCG, uE3, AFP and Inhibin A significantly outperformed other test combinations that involved only one serum marker or NT in the first trimester, detecting about nine out of every 10 Down's syndrome pregnancies at a 5% false positive rate. However, the evidence was limited in terms of the number of studies evaluating this strategy, and we therefore cannot recommend one single screening strategy. AUTHORS' CONCLUSIONS: Tests involving first trimester ultrasound with first and second trimester serum markers in combination with maternal age are significantly better than those without ultrasound, or those evaluating first trimester ultrasound in combination with second trimester serum markers, without first trimester serum markers. We cannot make recommendations about a specific strategy on the basis of the small number of studies available.
[Mh] Termos MeSH primário: Síndrome de Down/sangue
Síndrome de Down/diagnóstico
Medição da Translucência Nucal
Primeiro Trimestre da Gravidez/sangue
Segundo Trimestre da Gravidez/sangue
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Gonadotropina Coriônica/sangue
Síndrome de Down/diagnóstico por imagem
Estriol/sangue
Reações Falso-Positivas
Feminino
Seres Humanos
Inibinas/sangue
Idade Materna
Gravidez
Proteína Plasmática A Associada à Gravidez/análise
Sensibilidade e Especificidade
alfa-Fetoproteínas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Chorionic Gonadotropin); 0 (alpha-Fetoproteins); 0 (inhibin A); 57285-09-3 (Inhibins); EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A); FB33469R8E (Estriol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD012599


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[PMID]:28278220
[Au] Autor:Lim H; Powell S; Mcnamara HC; Howie AF; Doust A; Bowman ME; Smith R; Norman JE; Stock SJ
[Ad] Endereço:Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh Queen's Medical Research Institute, Edinburgh, United Kingdom.
[Ti] Título:Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study.
[So] Source:PLoS One;12(3):e0173732, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth. STUDY DESIGN: Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (<34 weeks; n = 8), preterm (<37 weeks; n = 40) and term (37+ weeks; n = 50) deliveries. RESULTS: No significant differences were found between preterm and term deliveries in either absolute hormone concentrations or ratios. Estimated hormone concentrations and ratios at 26 weeks did not appear to predict preterm delivery. Salivary and serum hormone concentrations were generally poorly correlated. CONCLUSION: Our results suggest that serial progesterone, estradiol, estriol and corticotropin-releasing hormone measurements in saliva and serum are not robust biomarkers for preterm birth in twin pregnancies.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Trabalho de Parto Prematuro/diagnóstico
Hormônios Placentários/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Hormônio Liberador da Corticotropina/sangue
Estradiol/sangue
Estriol/sangue
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido
Trabalho de Parto Prematuro/sangue
Trabalho de Parto Prematuro/prevenção & controle
Valor Preditivo dos Testes
Gravidez
Segundo Trimestre da Gravidez
Gravidez de Gêmeos
Progesterona/sangue
Estudos Prospectivos
Radioimunoensaio
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; TWIN STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Placental Hormones); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); 9015-71-8 (Corticotropin-Releasing Hormone); FB33469R8E (Estriol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173732


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[PMID]:28260987
[Au] Autor:Hur J; Cho EH; Baek KH; Lee KJ
[Ad] Endereço:Department of Biomedical Sciences, University of North Dakota, Grand Forks, North Dakota, USA.
[Ti] Título:Prediction of Gestational Diabetes Mellitus by Unconjugated Estriol Levels in Maternal Serum.
[So] Source:Int J Med Sci;14(2):123-127, 2017.
[Is] ISSN:1449-1907
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the association between maternal serum estriol levels, which are routinely measured in the first trimester of pregnancy, and adverse pregnancy outcomes including gestational diabetes. We performed a retrospective chart analysis of women who delivered between July 1, 2007, and December 31, 2009, at Kangnam CHA Medical Center in Seoul, Korea. Only patients with available estriol measurements during their pregnancies and complete follow-up data were included in the study. The effect of estriol on the incidence of adverse pregnancy outcomes was examined using multinomial logistic regression analysis with age and pre-pregnancy body mass index (BMI) as covariates. The total number of subjects was 1,553, the mean age was 32.9 ± 3.7 years, and the mean pre-pregnancy BMI was 21.2 ± 3.0 kg/m . Unconjugated estriol > 95 percentile of the screened population or unconjugated estriol ≥ 2.0 MoM (Multiple of the Median) was significantly associated with an increased risk for developing gestational diabetes mellitus (GDM), after adjusting for age and pre-pregnancy maternal weight. High levels of unconjugated estriol in the maternal serum during the early second trimester of pregnancy are a useful predictor of GDM development.
[Mh] Termos MeSH primário: Diabetes Gestacional/sangue
Diabetes Gestacional/diagnóstico
Estriol/sangue
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Gravidez
Resultado da Gravidez
Primeiro Trimestre da Gravidez/sangue
Segundo Trimestre da Gravidez/sangue
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
FB33469R8E (Estriol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.7150/ijms.17321


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[PMID]:28178056
[Au] Autor:Ananth CV; Wapner RJ; Ananth S; DʼAlton ME; Vintzileos AM
[Ad] Endereço:Department of Obstetrics and Gynecology, College of Physicians and Surgeons, and the Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York, New York; West Windsor-Plainsboro High School North, Plainsboro, New Jersey; and the Department of Obstetrics and Gynecology, Winthrop-University Hospital, Mineola, New York.
[Ti] Título:First-Trimester and Second-Trimester Maternal Serum Biomarkers as Predictors of Placental Abruption.
[So] Source:Obstet Gynecol;129(3):465-472, 2017 Mar.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We hypothesized that the origins of abruption may extend to the stages of placental implantation; however, there are no reliable markers to predict its development. Based on this hypothesis, we sought to evaluate whether first-trimester and second-trimester serum analytes predict placental abruption. METHODS: We performed a secondary analysis of data of 35,307 women (250 abruption cases) enrolled in the First and Second Trimester Evaluation of Risk cohort (1999-2003), a multicenter, prospective cohort study. Percentiles (based on multiples of the median) of first-trimester (pregnancy-associated plasma protein A and total and free ß-hCG) and second-trimester (maternal serum alpha-fetoprotein, unconjugated estriol, and inhibin-A) serum analytes were examined in relation to abruption. Associations are based on risk ratio (RR) and 95% confidence interval (CI). RESULTS: Women with an abnormally low pregnancy-associated plasma protein A (fifth percentile or less) were at increased risk of abruption compared with those without abruption (9.6% compared with 5.3%; RR 1.9, 95% CI, 1.2-2.8). Maternal serum alpha-fetoprotein 95th percentile or greater was more common among abruption (9.6%) than nonabruption (5.1%) pregnancies (RR 1.9, 95% CI 1.3-3.0). Inhibin-A fifth percentile or less (8.0% compared with 5.1%; RR 1.8, 95% CI 1.1-2.9), and 95th percentile or greater (9.6% compared with 5.0%; RR 2.0, 95% CI 1.3-3.1) were associated with abruption. Women with all three abnormal pregnancy-associated plasma protein A, maternal serum alpha-fetoprotein, and inhibin-A analytes were at 8.8-fold (95% CI 2.3-34.3) risk of abruption. No associations were seen with other analytes. CONCLUSION: These data provide support for our hypothesis that the origins of placental abruption may extend to the early stages of pregnancy.
[Mh] Termos MeSH primário: Descolamento Prematuro da Placenta/sangue
Inibinas/sangue
Primeiro Trimestre da Gravidez/sangue
Segundo Trimestre da Gravidez/sangue
Proteína Plasmática A Associada à Gravidez/metabolismo
alfa-Fetoproteínas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Gonadotropina Coriônica Humana Subunidade beta/sangue
Estriol/sangue
Feminino
Seres Humanos
Gravidez
Estudos Prospectivos
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Chorionic Gonadotropin, beta Subunit, Human); 0 (alpha-Fetoproteins); 0 (inhibin A); 57285-09-3 (Inhibins); EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A); FB33469R8E (Estriol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000001889


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[PMID]:27898283
[Au] Autor:Villarroel C; Salinas A; López P; Kohen P; Rencoret G; Devoto L; Codner E
[Ad] Endereço:a Institute for Mother and Child Research (IDIMI), University of Chile , Santa Rosa 1234, Santiago , Chile.
[Ti] Título:Pregestational type 2 diabetes and gestational diabetes exhibit different sexual steroid profiles during pregnancy.
[So] Source:Gynecol Endocrinol;33(3):212-217, 2017 Mar.
[Is] ISSN:1473-0766
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Higher androgen levels are observed in non-pregnant women with diabetes. Whether this hormonal profile is found during pregnancy is unknown. The aim of this study was to determine the sexual steroids levels in pregnant women with pregestational type 2 (T2D) and gestational diabetes (GD) compared to healthy control (C) pregnant women during the second half of pregnancy. A prospective study of 69 pregnant women with T2D (n = 21), GD (n = 24) and control (C, n = 24) was followed up during the second half of gestation. Clinical assessments and blood samples were collected at 26.7 (25-27.8); 34 (32-34.9) and 37.5 (37-40) weeks of gestation. Androgens, sex hormone-binding globulin (SHBG), estrogens, estradiol/testosterone (E/T) ratio, insulin, glucose, HOMA-IR, were measured. Testosterone, insulin and homeostatic model assessment of insulin resistance (HOMA-IR) levels were higher in T2D compared with C at each sampling point during pregnancy, even after adjusting for BMI and age. Estrogens levels and estradiol/testosterone ratio were lower in T2D and GD compared with C. Hyperandrogenemia, and higher insulin resistance is observed in T2D, but not in GD during pregnancy. Decreased estrogen and E/T ratio found in T2D and GD suggests a diminished aromatase activity during gestation. T2D and GD are associated with specific changes in sexual steroids and insulin resistance levels during pregnancy.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/complicações
Diabetes Gestacional/sangue
Hiperandrogenismo/complicações
Hiperinsulinismo/complicações
Resistência à Insulina
Gravidez em Diabéticas/sangue
[Mh] Termos MeSH secundário: Adulto
Androstenodiona/sangue
Chile
Sulfato de Desidroepiandrosterona/sangue
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/metabolismo
Diabetes Gestacional/metabolismo
Diabetes Gestacional/fisiopatologia
Regulação para Baixo
Estradiol/sangue
Estriol/sangue
Estrona/sangue
Feminino
Seres Humanos
Hiperandrogenismo/etiologia
Hiperinsulinismo/etiologia
Estudos Longitudinais
Gravidez
Segundo Trimestre da Gravidez
Terceiro Trimestre da Gravidez
Gravidez em Diabéticas/metabolismo
Gravidez em Diabéticas/fisiopatologia
Estudos Prospectivos
Centros de Atenção Terciária
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
2DI9HA706A (Estrone); 409J2J96VR (Androstenedione); 4TI98Z838E (Estradiol); 57B09Q7FJR (Dehydroepiandrosterone Sulfate); FB33469R8E (Estriol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE
[do] DOI:10.1080/09513590.2016.1248933


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[PMID]:27002285
[Au] Autor:Wingeier M; La Marca-Ghaemmaghami P; Zimmermann R; Ehlert U
[Ad] Endereço:a Department of Clinical Psychology and Psychotherapy , University of Zurich , Zurich , Switzerland and.
[Ti] Título:Is salivary estriol detectable in very early pregnancy?
[So] Source:J Matern Fetal Neonatal Med;30(2):228-232, 2017 Jan.
[Is] ISSN:1476-4954
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Estriol (E3) is produced by the placenta and is important for early pregnancy maintenance. In blood, E3 can be detected from the 8th week of pregnancy. Under the influence of the hypothalamic-pituitary-adrenal (HPA) axis hormone ACTH, E3 levels increase sharply after the 10th week. Although E3 can be reliably analyzed in saliva, till now information about the concentrations during the first trimester is missing. The aim of this study was to verify whether the sensitivity of a newly developed enzyme immunoassay is sufficient for the determination of salivary E3 (sE3) in very early pregnancy. METHODS: Saliva samples were collected at home, once weekly in 25 healthy pregnant women from the 6th week of gestation to the end of the first trimester. RESULTS: sE3 was detectable from the beginning of the 6th pregnancy week (M = 3.17 pg/ml, SD = 2.13). A steep significant increase between the 7th and the 8th week (p = 0.029) and again between the 10th and the 11th week (p = 0.001) was apparent. CONCLUSION: Low concentrations of sE3 can be measured during very early pregnancy and may serve as a promising, easily assessable marker for future research on the mechanisms of healthy pregnancy.
[Mh] Termos MeSH primário: Estriol/análise
Técnicas Imunoenzimáticas/métodos
Saliva/química
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Projetos Piloto
Gravidez
Primeiro Trimestre da Gravidez
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
FB33469R8E (Estriol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE



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