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[PMID]:28380538
[Au] Autor:Smith ZK; Chung KY; Parr SL; Johnson BJ
[Ti] Título:Anabolic payout of terminal implant alters adipogenic gene expression of the longissimus muscle in beef steers.
[So] Source:J Anim Sci;95(3):1197-1204, 2017 Mar.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This experiment evaluated the dose and payout pattern of trenbolone acetate (TBA) and estradiol-17ß (E) on LM mRNA expression of adenosine monophosphate-activated protein kinase-É‘ (-É‘), ß, G protein-coupled receptor 41(), G protein-coupled receptor 43 (), γ, and stearoyl CoA desaturase () in finishing feedlot steers as indicators of adipogenesis and marbling development. British × Continental steers (n = 168; 14 pens/treatment; initial BW = 362 kg) were used in a randomized complete block design. Treatments included: no implant (NI), Revalor-S (REV-S; 120 mg TBA + 24 mg E), or Revalor-XS (REV-X; delayed release implant: 80 mg TBA + 16 mg E [uncoated], 120 mg TBA + 24 mg E [coated], 200 mg TBA + 40 mg E [total]). Steers were fed 1 time daily for an average of 164 d. The LM biopsies were collected (1 steer/pen) on d -1, 27, 55, and 111 relative to timing of implant. Total RNA was isolated from each sample and real-time quantitative PCR was used to measure quantity of -É‘, ß, , ,it, γ, and mRNA. No implant × day interactions were detected ( ≥ 0.19) in this experiment. Day impacted the mRNA expression of all adipogenic genes ( ≤ 0.02). The main effect of implant tended ( = 0.09) to influence expression of -É‘, REV-X had an 8.8% increase over NI and an 18.7% increase over REV-S. Implant influenced ( = 0.03) mRNA expression of , expression of for the REV-X treatment was not different ( > 0.10) from NI, and both were greater ( ≤ 0.05) than REV-S (1.13, 1.00, and 0.67 ± 0.224 arbitrary units) for REV-X, NI, and REV-S, respectively. Implant also influenced ( = 0.02) expression of , expression of for REV-X was not different ( > 0.10) from NI, and both were greater ( ≤ 0.05) than REV-S (1.27, 1.07, and 0.72 ± 0.234 arbitrary units) for REV-X, NI, and REV-S, respectively. Implant influenced ( = 0.02) mRNA expression of γ in LM tissue, expression of γ for REV-X was not different ( > 0.10) from NI, and both were greater ( ≤ 0.05) than REV-S (1.09, 1.02, and 0.69 ± 0.195 arbitrary units) for REV-X, NI, and REV-S, respectively. The REV-X steers received the greatest anabolic dose of TBA + E without detriment to marbling scores. The increased mRNA expression of adipogenic genes for REV-X steers suggest that the delayed and gradual release of anabolic stimulants associated with REV-X might have mitigated decreases in marbling generally attributed to multiple combined TBA + E implants.
[Mh] Termos MeSH primário: Adipogenia/efeitos dos fármacos
Bovinos/fisiologia
Estradiol/farmacologia
Regulação da Expressão Gênica/efeitos dos fármacos
Acetato de Trembolona/análogos & derivados
[Mh] Termos MeSH secundário: Adipogenia/fisiologia
Anabolizantes/administração & dosagem
Anabolizantes/farmacologia
Animais
Preparações de Ação Retardada
Combinação de Medicamentos
Implantes de Medicamento
Estradiol/administração & dosagem
Masculino
RNA Mensageiro/metabolismo
Acetato de Trembolona/administração & dosagem
Acetato de Trembolona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anabolic Agents); 0 (Delayed-Action Preparations); 0 (Drug Combinations); 0 (Drug Implants); 0 (RNA, Messenger); 39450-18-5 (Revalor); 4TI98Z838E (Estradiol); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016.0630


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[PMID]:28372163
[Au] Autor:Lega F; Angeletti R; Stella R; Rigoni L; Biancotto G; Giusepponi D; Moretti S; Saluti G; Galarini R
[Ad] Endereço:Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, I-35020 Legnaro (PD), Italy.
[Ti] Título:Abuse of anabolic agents in beef cattle: Could bile be a possible alternative matrix?
[So] Source:Food Chem;229:188-197, 2017 Aug 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:European Union prohibited the use of anabolic agents in food producing animals since 1988. An efficient control of abuses is guaranteed not only by highly performing analytical methods, but also by knowledge of metabolic pathways, kinetics of elimination and tissue distribution. To obtain data concerning metabolites production and accumulation in bile, two typical growth promoting treatments are carried out in cattle. In the first study, sixteen beef cattle were implanted with trenbolone acetate and estradiol. In the second one, three animals were implanted with zeranol and three were fed a diet containing zearalenone. Methods based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) were developed and validated to quantify the analytes of interest. The results evidenced that the biliary concentrations of the marker residues were always higher than those determined at the same time in urine and liver which are the matrices generally collected within the official monitoring programmes.
[Mh] Termos MeSH primário: Anabolizantes/efeitos adversos
Bile/química
Cromatografia Líquida/métodos
Carne Vermelha/efeitos adversos
Espectrometria de Massas em Tandem/métodos
Acetato de Trembolona/química
[Mh] Termos MeSH secundário: Animais
Bovinos
Carne Vermelha/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


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[PMID]:28168557
[Au] Autor:Geiß C; Ruppert K; Askem C; Barroso C; Faber D; Ducrot V; Holbech H; Hutchinson TH; Kajankari P; Kinnberg KL; Lagadic L; Matthiessen P; Morris S; Neiman M; Penttinen OP; Sanchez-Marin P; Teigeler M; Weltje L; Oehlmann J
[Ad] Endereço:Department Aquatic Ecotoxicology, Goethe University Frankfurt am Main, Max-von-Laue-Str. 13, Frankfurt am Main, 60438, Germany. geiss@bio.uni-frankfurt.de.
[Ti] Título:Validation of the OECD reproduction test guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz.
[So] Source:Ecotoxicology;26(3):370-382, 2017 Apr.
[Is] ISSN:1573-3017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Organisation for Economic Cooperation and Development (OECD) provides several standard test methods for the environmental hazard assessment of chemicals, mainly based on primary producers, arthropods, and fish. In April 2016, two new test guidelines with two mollusc species representing different reproductive strategies were approved by OECD member countries. One test guideline describes a 28-day reproduction test with the parthenogenetic New Zealand mudsnail Potamopyrgus antipodarum. The main endpoint of the test is reproduction, reflected by the embryo number in the brood pouch per female. The development of a new OECD test guideline involves several phases including inter-laboratory validation studies to demonstrate the robustness of the proposed test design and the reproducibility of the test results. Therefore, a ring test of the reproduction test with P. antipodarum was conducted including eight laboratories with the test substances trenbolone and prochloraz and results are presented here. Most laboratories could meet test validity criteria, thus demonstrating the robustness of the proposed test protocol. Trenbolone did not have an effect on the reproduction of the snails at the tested concentration range (nominal: 10-1000 ng/L). For prochloraz, laboratories produced similar EC and NOEC values, showing the inter-laboratory reproducibility of results. The average EC and NOEC values for reproduction (with coefficient of variation) were 26.2 µg/L (61.7%) and 29.7 µg/L (32.9%), respectively. This ring test shows that the mudsnail reproduction test is a well-suited tool for use in the chronic aquatic hazard and risk assessment of chemicals.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Guias como Assunto
Imidazóis/toxicidade
Organização para a Cooperação e Desenvolvimento Econômico
Caramujos/fisiologia
Testes de Toxicidade/estatística & dados numéricos
Acetato de Trembolona/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Anabolizantes
Animais
Disruptores Endócrinos
Monitoramento Ambiental/normas
Feminino
Fungicidas Industriais/toxicidade
Nova Zelândia
Reprodutibilidade dos Testes
Reprodução/efeitos dos fármacos
Medição de Risco/métodos
Medição de Risco/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); 0 (Endocrine Disruptors); 0 (Fungicides, Industrial); 0 (Imidazoles); 0 (Water Pollutants, Chemical); 99SFL01YCL (prochloraz); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1007/s10646-017-1770-y


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[PMID]:28074716
[Au] Autor:Zanardello C; Capello K; Stella R; Biancotto G; Vascellari M
[Ad] Endereço:Histopathology Department (Zanardello, Vascellari), Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padua, Italy.
[Ti] Título:Semiquantitative immunohistochemical detection of progesterone receptors in male accessory sex glands as a screening assay for anabolic steroid use in bulls.
[So] Source:J Vet Diagn Invest;29(1):35-40, 2017 Jan.
[Is] ISSN:1943-4936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the immunohistochemical expression of progesterone receptors (PRs) in the prostate and bulbourethral glands of thirty-two 10-14-mo-old Charolais bulls following treatment with a low dosage of estrogens. Animals were divided into 2 groups: 16 animals (group T) were treated for 71 d with a therapeutic dose of trenbolone acetate and estradiol by subcutaneous implant, 16 animals (group C) received no treatment. Urine samples were collected both at the beginning of the trial and 9 times during the study. A semiquantitative analysis of immunohistochemistry (IHC) was performed by counting the number of positive cells in 10 randomly selected high-power fields (hpf). Both groups showed no significant histologic lesions. IHC examination showed positive cells in the epithelium of both glands, with different patterns of distribution between groups. In group C, IHC-positive cells per hpf varied from 0 to 40 in the prostate and from 0 to 32 in the bulbourethral gland. In group T, positive cells varied from 0 to 85 per hpf in the prostate and from 0 to 75 in the bulbourethral gland. The treated group showed significantly higher median numbers of positively stained cells in both organs than the controls ( p < 0.001). Chemical analysis of the urine samples confirmed that the experimental treatment mimics continuous, low-dose administration of anabolic steroids. IHC quantification showed good sensitivity with a high predictive power to correctly classify treated animals and could be used as a preliminary screening test in bulls.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Glândulas Bulbouretrais/metabolismo
Bovinos/fisiologia
Receptores de Progesterona/metabolismo
Detecção do Abuso de Substâncias/veterinária
[Mh] Termos MeSH secundário: Animais
Biomarcadores/urina
Implantes de Medicamento
Estrogênios/administração & dosagem
Imuno-Histoquímica/veterinária
Masculino
Valor Preditivo dos Testes
Congêneres da Testosterona/administração & dosagem
Acetato de Trembolona/administração & dosagem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Drug Implants); 0 (Estrogens); 0 (Receptors, Progesterone); 0 (Testosterone Congeners); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1177/1040638716681047


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[PMID]:28043359
[Au] Autor:Ziecik AJ; Klos J; Przygrodzka E; Milewski R; Jana B
[Ad] Endereço:Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland. Electronic address: a.ziecik@pan.olsztyn.pl.
[Ti] Título:Aberrant effects of altrenogest and exposure to exogenous gonadotropins on follicular cysts appearance in gilts.
[So] Source:Theriogenology;89:250-254, 2017 Feb.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Research was conducted to determine the effect of altrenogest and exposure to exogenous gonadotropins on ovarian function in prepubertal and mature gilts. Crossbred, presumably sexually mature gilts (n = 51), were fed with altrenogest for 18 consecutive days and the day after the last feeding with altrenogest, gilts were treated with eCG and 72 hours later challenged with hCG. Animals were slaughtered on Days 10 to 13 of their gonadotropins synchronized estrous cycle. Ovaries were examined for the number of CL, number of follicular cysts, and presence of corpora albicantia. Gilts were divided into two groups: those possessing corpora albicantia (group A-mature; n = 36) and those without corpora albicantia (Group W-prepubertal; n = 15) on their ovaries. In addition, each group was divided into two subgroups depending on the presence of follicular cysts (AC and WC) or their absence (AO and WO). There was no difference between the number of CL in group A and group W. Presence of corpora albicantia determined percentage of gilts possessing follicular cysts (13.9% group A vs. 66.7% group W). Gilts without follicular cysts (AO plus WO; n = 36) had higher number of CL (P < 0.01) than gilts bearing cysts (AC plus WC; n = 15). Comparison AO-AC did not show significant difference (P = 0.075) between CL number in mature cyst-free and cysts bearing gilts. A prepubertal gilts not bearing follicular cysts (WO) had higher (P < 0.02) number of CL than gilts bearing cysts. A significant negative correlation between the number of CL and number of follicular cysts was found (r = -0.664; P = 0.007). There were no differences in blood plasma progesterone and estradiol concentration between cyst-free and cyst-bearing gilts. These results indicate: (1) a higher follicular cysts appearance in prepubertal than mature gilts challenged with altrenogest and exposed to exogenous gonadotropins and (2) a negative effect of follicular cysts on the number of CL (ovulations) in prepubertal gilts.
[Mh] Termos MeSH primário: Cisto Folicular/induzido quimicamente
Gonadotropinas/farmacologia
Folículo Ovariano/efeitos dos fármacos
Progestinas/farmacologia
Suínos/fisiologia
Acetato de Trembolona/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Gonadotropina Coriônica/farmacologia
Corpo Lúteo/efeitos dos fármacos
Corpo Lúteo/patologia
Estradiol/sangue
Sincronização do Estro
Feminino
Cisto Folicular/patologia
Progesterona/sangue
Acetato de Trembolona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chorionic Gonadotropin); 0 (Gonadotropins); 0 (Progestins); 2U0X0JA2NB (altrenogest); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE


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[PMID]:27958649
[Au] Autor:Robinson JA; Ma Q; Staveley JP; Smolenski WJ
[Ad] Endereço:Zoetis, Kalamazoo, Michigan, USA.
[Ti] Título:Sorption and desorption of 17α-trenbolone and trendione on five soils.
[So] Source:Environ Toxicol Chem;36(3):613-620, 2017 Mar.
[Is] ISSN:1552-8618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The metabolites 17α-trenbolone and 17α-estradiol are principal metabolites in cattle excreta following the administration of Synovex ONE, which contains trenbolone acetate and estradiol benzoate. As part of the environmental assessment of the use of Synovex ONE, data were generated to characterize the fate of 17α-trenbolone, and its metabolite trendione in the environment. Predictions of the fate and environmental concentrations of these hormones after land application require accurate estimates of the sorption of these compounds in soils. The sorption and desorption of 17α-trenbolone and trendione were measured at 5 nominal concentrations in 5 soils from different geologic settings using a batch equilibrium technique following guideline 106 of the Organisation for Economic Co-operation and Development. Both the sorption and desorption of 17α-trenbolone and trendione to soils were adequately described by the Freundlich sorption model and by linear partition coefficients. The mean sorption coefficients were 9.04 mL/g and 32.2 mL/g for 17α-trenbolone and trendione, respectively. The corresponding mean Freundlich sorption exponents were 0.88 and 0.98, respectively. Sorption of 17α-trenbolone and trendione was correlated principally with soil organic carbon. Average sorption coefficients normalized to soil organic carbon content (K ) were 460 mL/g and 1804 mL/g for 17α-trenbolone and trendione, respectively. The mean desorption coefficients were 22.1 mL/g and 43.8 mL/g for 17α-trenbolone and trendione, respectively. Calculated hysteresis coefficients based on the difference in the area between sorption and desorption isotherms indicated that sorption equilibrium was not fully reversible and hysteresis of desorption isotherms occurred for both 17α-trenbolone and trendione. Environ Toxicol Chem 2017;36:613-620. © 2016 SETAC.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Estrenos/química
Poluentes do Solo/química
Solo/química
Acetato de Trembolona/química
[Mh] Termos MeSH secundário: Adsorção
Animais
Bovinos
Estradiol/análogos & derivados
Estradiol/química
Estradiol/metabolismo
Estrenos/metabolismo
Fezes/química
Guias como Assunto
Cinética
Modelos Teóricos
Estrutura Molecular
Montana
North Dakota
Organização para a Cooperação e Desenvolvimento Econômico
Poluentes do Solo/metabolismo
Acetato de Trembolona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrenes); 0 (Soil); 0 (Soil Pollutants); 1S4CJB5ZGN (estradiol 3-benzoate); 4642-95-9 (trendione); 4TI98Z838E (Estradiol); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.1002/etc.3711


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[PMID]:27312088
[Au] Autor:Villeneuve DL; Jensen KM; Cavallin JE; Durhan EJ; Garcia-Reyero N; Kahl MD; Leino RL; Makynen EA; Wehmas LC; Perkins EJ; Ankley GT
[Ad] Endereço:Mid-Continent Ecology Division, US Environmental Protection Agency, Duluth, Minnesota, USA.
[Ti] Título:Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17ß-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas).
[So] Source:Environ Toxicol Chem;36(1):231-242, 2017 Jan.
[Is] ISSN:1552-8618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system. The present study examined the effects of TCC alone and in combination with the model endocrine disruptor 17ß-trenbolone (TRB) on fish reproductive function. Adult Pimephales promelas were continuously exposed to either 1 µg TCC/L or 5 µg TCC/L, to 0.5 µg TRB/L, or to a mixture (MIX) of 5 µg TCC/L and 0.5 µg TRB/L for 22 d, and a variety of reproductive and endocrine-related endpoints were examined. Cumulative fecundity was significantly reduced in fathead minnows exposed to TRB, MIX, or 5 µg TCC/L. Exposure to 1 µg TCC/L had no effect on reproduction. In general, both TRB and MIX treatments caused similar physiological effects, evoking significant reductions in female plasma vitellogenin, estradiol, and testosterone, and significant increases in male plasma estradiol. Based on analysis of the ovarian transcriptome, there were potential pathway impacts that were common to both TRB- and TCC-containing treatment groups. In most cases, however, those pathways were more plausibly linked to differences in reproductive status than to androgen-specific functions. Overall, TCC was reproductively toxic to fish at concentrations at or near those that have been measured in surface water. There was little evidence that TCC elicits reproductive toxicity through a specific mode of endocrine or reproductive action, nor that it could augment the androgenic effects of TRB. Nonetheless, the relatively small margin of safety between some measured environmental concentrations and effect concentrations suggests that concern is warranted. Environ Toxicol Chem 2017;36:231-242. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
[Mh] Termos MeSH primário: Androgênios/toxicidade
Anti-Infecciosos/toxicidade
Carbanilidas/toxicidade
Cyprinidae/crescimento & desenvolvimento
Disruptores Endócrinos/toxicidade
Ovário/efeitos dos fármacos
Transcriptoma/efeitos dos fármacos
Acetato de Trembolona/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Androgênios/análise
Animais
Anti-Infecciosos/análise
Carbanilidas/análise
Cyprinidae/fisiologia
Sinergismo Farmacológico
Disruptores Endócrinos/análise
Sistema Endócrino/efeitos dos fármacos
Estradiol/sangue
Feminino
Fertilidade/efeitos dos fármacos
Masculino
Ovário/metabolismo
Reprodução/efeitos dos fármacos
Testosterona/sangue
Acetato de Trembolona/análise
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgens); 0 (Anti-Infective Agents); 0 (Carbanilides); 0 (Endocrine Disruptors); 0 (Water Pollutants, Chemical); 3XMK78S47O (Testosterone); 4TI98Z838E (Estradiol); BGG1Y1ED0Y (triclocarban); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE
[do] DOI:10.1002/etc.3531


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[PMID]:27302316
[Au] Autor:Robinson JA; Staveley JP; Constantine L
[Ad] Endereço:Zoetis, Kalamazoo, Michigan, USA.
[Ti] Título:Reproductive effects on freshwater fish exposed to 17α-trenbolone and 17α-estradiol.
[So] Source:Environ Toxicol Chem;36(3):636-644, 2017 Mar.
[Is] ISSN:1552-8618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:17α-Trenbolone and 17α-estradiol are principal metabolites in cattle excreta following the administration of Synovex ONE, which contains trenbolone acetate and estradiol benzoate. As part of the environmental assessment of the use of Synovex ONE, data were generated to characterize the effects of 17α-trenbolone and 17α-estradiol on the reproduction of freshwater fish. These substances are known endocrine disruptors, so the purpose of testing was not to clarify these properties but to identify concentrations representing population-relevant effects for use in risk characterization. The short-term reproduction assay was conducted with 17α-trenbolone using the fathead minnow (Pimephales promelas) and the medaka (Oryzias latipes) and with 17α-estradiol using the fathead minnow. Adverse effects on the population-relevant endpoints of survival and fecundity were used to establish the no-observed-effect concentration (NOEC) and the lowest-observed-effect concentration (LOEC) for each study. For 17α-trenbolone, adverse effects on fecundity of the fathead minnow occurred at 120 ng/L; this was the LOEC, and the NOEC was 35 ng/L. 17ß-Trenbolone did not adversely affect survival and fecundity of medaka at the concentrations tested, resulting in a NOEC of 110 ng/L and a LOEC of >110 ng/L. 17α-Estradiol did not adversely impact survival and fecundity of the fathead minnow at the concentrations tested, resulting in a NOEC and LOEC of 250 ng/L and >250 ng/L, respectively. Environ Toxicol Chem 2017;36:636-644. © 2016 SETAC.
[Mh] Termos MeSH primário: Cyprinidae/metabolismo
Monitoramento Ambiental/métodos
Estradiol/toxicidade
Oryzias/metabolismo
Reprodução/efeitos dos fármacos
Acetato de Trembolona/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Bioensaio
Bovinos
Cyprinidae/fisiologia
Estradiol/análogos & derivados
Estradiol/metabolismo
Feminino
Água Doce/química
Masculino
Oryzias/fisiologia
Acetato de Trembolona/metabolismo
Vitelogeninas/metabolismo
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vitellogenins); 0 (Water Pollutants, Chemical); 1S4CJB5ZGN (estradiol 3-benzoate); 4TI98Z838E (Estradiol); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE
[do] DOI:10.1002/etc.3526


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[PMID]:27246614
[Au] Autor:Dalbo VJ; Roberts MD; Mobley CB; Ballmann C; Kephart WC; Fox CD; Santucci VA; Conover CF; Beggs LA; Balaez A; Hoerr FJ; Yarrow JF; Borst SE; Beck DT
[Ad] Endereço:Medical and Applied Sciences, Central Queensland University, Rockhampton, Qld, Australia.
[Ti] Título:Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle.
[So] Source:Andrologia;49(3), 2017 Apr.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The androgen-induced alterations in adult rodent skeletal muscle fibre cross-sectional area (fCSA), satellite cell content and myostatin (Mstn) were examined in 10-month-old Fisher 344 rats (n = 41) assigned to Sham surgery, orchiectomy (ORX), ORX + testosterone (TEST; 7.0 mg week ) or ORX + trenbolone (TREN; 1.0 mg week ). After 29 days, animals were euthanised and the levator ani/bulbocavernosus (LABC) muscle complex was harvested for analyses. LABC muscle fCSA was 102% and 94% higher in ORX + TEST and ORX + TREN compared to ORX (p < .001). ORX + TEST and ORX + TREN increased satellite cell numbers by 181% and 178% compared to ORX, respectively (p < .01), with no differences between conditions for myonuclear number per muscle fibre (p = .948). Mstn protein was increased 159% and 169% in the ORX + TEST and ORX + TREN compared to ORX (p < .01). pan-SMAD2/3 protein was ~30-50% greater in ORX compared to SHAM (p = .006), ORX + TEST (p = .037) and ORX + TREN (p = .043), although there were no between-treatment effects regarding phosphorylated SMAD2/3. Mstn, ActrIIb and Mighty mRNAs were lower in ORX, ORX + TEST and ORX + TREN compared to SHAM (p < .05). Testosterone and trenbolone administration increased muscle fCSA and satellite cell number without increasing myonuclei number, and increased Mstn protein levels. Several genes and signalling proteins related to myostatin signalling were differentially regulated by ORX or androgen therapy.
[Mh] Termos MeSH primário: Anabolizantes/farmacologia
Androgênios/farmacologia
Músculo Esquelético/efeitos dos fármacos
Miostatina/metabolismo
Células Satélites de Músculo Esquelético/efeitos dos fármacos
Testosterona/farmacologia
Acetato de Trembolona/farmacologia
[Mh] Termos MeSH secundário: Receptores de Activinas Tipo II/metabolismo
Anabolizantes/administração & dosagem
Androgênios/administração & dosagem
Animais
Contagem de Células
Diferenciação Celular/efeitos dos fármacos
Crescimento Celular/efeitos dos fármacos
Masculino
Músculo Esquelético/crescimento & desenvolvimento
Músculo Esquelético/metabolismo
Orquiectomia/efeitos adversos
Ratos
Ratos Endogâmicos F344
Células Satélites de Músculo Esquelético/citologia
Proteína Smad2/metabolismo
Proteína Smad3/metabolismo
Testículo/cirurgia
Testosterona/administração & dosagem
Acetato de Trembolona/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); 0 (Androgens); 0 (Gdf8 protein, rat); 0 (Madh2 protein, rat); 0 (Madh3 protein, rat); 0 (Myostatin); 0 (Smad2 Protein); 0 (Smad3 Protein); 3XMK78S47O (Testosterone); EC 2.7.11.30 (Activin Receptors, Type II); EC 2.7.11.30 (activin receptor type II-B); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE
[do] DOI:10.1111/and.12622


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[PMID]:26801177
[Au] Autor:Robinson JA; Ma Q; Staveley JP; Smolenski WJ; Ericson J
[Ad] Endereço:Zoetis, Kalamazoo, Michigan, USA.
[Ti] Título:Degradation and transformation of 17α-estradiol in water-sediment systems under controlled aerobic and anaerobic conditions.
[So] Source:Environ Toxicol Chem;36(3):621-629, 2017 Mar.
[Is] ISSN:1552-8618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One of the principal metabolites in cattle excreta following the administration of Synovex® ONE, which contains estradiol benzoate and trenbolone acetate, is 17α-estradiol. As part of the environmental assessment of the use of Synovex ONE, data were generated to characterize the fate of 17α-estradiol in the environment. Studies were conducted to determine the degradation and transformation of 17α-[ C]-estradiol in 2 representative water-sediment systems each under aerobic and anaerobic conditions. The same transformation products-estriol, 17ß-estradiol, and estrone-were formed, principally in the sediment phase, under both conditions in both systems. From the production of these transformation products, the 50% disappearance time (DT50) values of estrone and 17ß-estradiol were determined, along with the DT50 values of 17α-estradiol and the total drug (17α-estradiol + 17ß-estradiol + estrone). The results indicate that 17 α-[ C]-estradiol was more persistent under anaerobic conditions than under aerobic conditions and that 17 α-[ C]-estradiol was less persistent than its transformation products. The DT50 values for the total system (aqueous and sediment phases) and for the total residues (17α-estradiol, 17ß-estradiol, and estrone) were selected for use in modeling the environmental fate of estradiol benzoate. For aerobic degradation in the water-sediment system, the DT50 was 31.1 d, and it was 107.8 d for the anaerobic system. Environ Toxicol Chem 2017;36:621-629. © 2016 SETAC.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Estradiol/análise
Sedimentos Geológicos/química
Rios/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Aerobiose
Anaerobiose
Animais
Biodegradação Ambiental
Bovinos
Estradiol/análogos & derivados
Estradiol/metabolismo
Estrona/análise
Etinilestradiol/análise
Etinilestradiol/metabolismo
Fezes/química
Acetato de Trembolona/análise
Acetato de Trembolona/metabolismo
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 1S4CJB5ZGN (estradiol 3-benzoate); 2DI9HA706A (Estrone); 423D2T571U (Ethinyl Estradiol); 4TI98Z838E (Estradiol); RUD5Y4SV0S (Trenbolone Acetate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160124
[St] Status:MEDLINE
[do] DOI:10.1002/etc.3383



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