Base de dados : MEDLINE
Pesquisa : D04.210.500.668.651.568.291.500 [Categoria DeCS]
Referências encontradas : 2233 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 224 ir para página                         

  1 / 2233 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28060448
[Au] Autor:Perreault M; Maltais R; Roy J; Dutour R; Poirier D
[Ad] Endereço:Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec-Research Center (CHUL, T4-42), 2705 Laurier Boulevard, Québec City, Québec, G1V 4G2, Canada.
[Ti] Título:Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models.
[So] Source:ChemMedChem;12(2):177-182, 2017 Jan 20.
[Is] ISSN:1860-7187
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Anticancer structure-activity relationship studies on aminosteroid (5α-androstane) derivatives have emerged with a promising lead candidate: RM-133 (2ß-[1-(quinoline-2-carbonyl)pyrrolidine-2-carbonyl]-N-piperazine-5α-androstane-3α,17ß-diol), which possesses high in vitro and in vivo activities against several cancer cells, and selectivity over normal cells. However, the relatively weak metabolic stability of RM-133 has been a drawback to its progression toward clinical trials. We investigated the replacement of the androstane backbone by a more stable mestranol moiety. The resulting compound, called RM-581 ({4-[17α-ethynyl-17ß-hydroxy-3-methoxyestra-1,3,5(10)-trien-2-yl]piperazin-1-yl}[(2S)-1-(quinolin-2-ylcarbonyl)pyrrolidin-2-yl]methanone), was synthesized efficiently in only five steps from commercially available estrone. In comparison with RM-133, RM-581 was found to be twice as metabolically stable, retains potent cytotoxic activity in breast cancer MCF-7 cell culture, and fully blocks tumor growth in a mouse xenograft model of breast cancer. Advantageously, the selectivity over normal cells has been increased with this estrane version of RM-133. In fact, RM-581 showed a better selectivity index (15.3 vs. 3.0) for breast cancer MCF-7 cells over normal breast MCF-10A cells, and was found to be nontoxic toward primary human kidney proximal tubule cells at doses reaching 50 µm.
[Mh] Termos MeSH primário: Antineoplásicos/química
Desenho de Drogas
Mestranol/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/uso terapêutico
Antineoplásicos/toxicidade
Neoplasias da Mama/tratamento farmacológico
Neoplasias da Mama/metabolismo
Neoplasias da Mama/patologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Feminino
Seres Humanos
Células MCF-7
Mestranol/uso terapêutico
Mestranol/toxicidade
Camundongos
Camundongos Nus
Transplante Heterólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); B2V233XGE7 (Mestranol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1002/cmdc.201600482


  2 / 2233 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26874877
[Au] Autor:Matic Bujagic I; Grujic S; Jaukovic Z; Lausevic M
[Ad] Endereço:University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia.
[Ti] Título:Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia.
[So] Source:Environ Pollut;213:76-83, 2016 Jun.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this work, source pollution tracing of the sediments of the Danube River and its tributaries in Serbia was performed using sterol ratios. Improved liquid chromatography-tandem mass spectrometry method, which enabled complete chromatographic separation of four analytes with identical fragmentation reactions (epicoprostanol, coprostanol, epicholestanol and cholestanol), was applied for the determination of steroid compounds (hormones, human/animal and plant sterols). A widespread occurrence of sterols was identified in all analyzed samples, whereas the only detected hormones were mestranol and 17α-estradiol. A human-sourced sewage marker coprostanol was detected at the highest concentration (up to 1939 ng g(-1)). The ratios between the key sterol biomarkers, as well as the percentage of coprostanol relative to the total sterol amount, were applied with the aim of selecting the most reliable for distinction between human-sourced pollution and the sterols originated from the natural sources in river sediments. The coprostanol/(cholesterol + cholestanol) and coprostanol/epicoprostanol ratios do not distinguish between human and natural sources of sterols in the river sediments in Serbia. The most reliable sterol ratios for the sewage pollution assessment of river sediments in the studied area were found to be coprostanol/(coprostanol + cholestanol), coprostanol/cholesterol and epicoprostanol/coprostanol. For the majority of sediments, human-derived pollution was determined. Two sediment samples were identified as influenced by a combination of human and natural biogenic sources.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Poluição Ambiental/análise
Sedimentos Geológicos/análise
Rios/química
Esgotos/análise
[Mh] Termos MeSH secundário: Animais
Colestanol/análise
Colestanóis/análise
Colesterol/análise
Cromatografia Líquida
Estradiol/análise
Seres Humanos
Mestranol/análise
Sérvia
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholestanols); 0 (Sewage); 0 (epicoprostanol); 4TI98Z838E (Estradiol); 8M308U816E (Cholestanol); 97C5T2UQ7J (Cholesterol); B2V233XGE7 (Mestranol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160215
[St] Status:MEDLINE


  3 / 2233 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25924705
[Au] Autor:Hu JH; Wang L; Li WS; Dai DP; Cai JP; Hu GX
[Ad] Endereço:National Center for Clinical Laboratories, Beijing Hospital, Beijing, PR China.
[Ti] Título:Effect of CYP2C9 Genetic Polymorphism in a Chinese Population on the Metabolism of Mestranol in vitro.
[So] Source:Pharmacology;95(5-6):218-23, 2015.
[Is] ISSN:1423-0313
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mestranol is a widely used estrogen, which is converted into its active metabolite ethinyl estradiol by cytochrome P450 (CYP) 2C9. To comprehensively examine the enzymatic activity of reported CYP2C9 variants in Chinese individuals in response to mestranol, wild-type CYP2C9*1 and 35 allelic variants were highly expressed in Sf21 insect cell microsomes and used for the detection of their enzymatic values in vitro. These results showed that the majority of tested variants exhibited decreased clearance values compared to wild type, except for CYP2C9*40 and *36. METHOD: Insect microsomes expressing the 36 CYP2C9 variants were incubated with 0.25-8 µmol/l mestranol for 30 min at 37°C. Then, the production of the metabolite of mestranol, ethinyl estradiol, was analyzed using high-performance liquid chromatography. RESULTS: Most CYP-catalyzed reactions were sufficiently described by classical Michaelis-Menten kinetic parameters (e.g., Km and Vmax), while 9 variants exhibited atypical or non-Michaelis-Menten kinetic values, which were largely due to the self-inhibitory effect in response to mestranol. CONCLUSION: This is the first report of these rare alleles for mestranol metabolism, which provides fundamental data for further clinical studies on CYP2C9 alleles for mestranol metabolism.
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Asiático/genética
Citocromo P-450 CYP2C9/genética
Estrogênios/metabolismo
Mestranol/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Insetos
Microssomos/metabolismo
Polimorfismo Genético
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Estrogens); B2V233XGE7 (Mestranol); EC 1.14.13.- (CYP2C9 protein, human); EC 1.14.13.- (Cytochrome P-450 CYP2C9)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150501
[St] Status:MEDLINE
[do] DOI:10.1159/000381189


  4 / 2233 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:23796326
[Au] Autor:Rodríguez-Molina B; Pérez-Estrada S; Garcia-Garibay MA
[Ad] Endereço:Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095-1569, United States.
[Ti] Título:Amphidynamic crystals of a steroidal bicyclo[2.2.2]octane rotor: a high symmetry group that rotates faster than smaller methyl and methoxy groups.
[So] Source:J Am Chem Soc;135(28):10388-95, 2013 Jul 17.
[Is] ISSN:1520-5126
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The synthesis, crystallization, single crystal X-ray structure, and solid state dynamics of molecular rotor 3 provided with a high symmetry order and relatively cylindrical bicyclo[2.2.2]octane (BCO) rotator linked to mestranol fragments were investigated in this work. By use of solid state (13)C NMR, three rotating fragments were identified within the molecule: the BCO, the C19 methoxy and the C18 methyl groups. To determine the dynamics of the BCO group in crystals of 3 by variable temperature (1)H spin-lattice relaxation (VT (1)H T1), we determined the (1)H T1 contributions from the methoxy group C19 by carrying out measurements with the methoxy-deuterated isotopologue rotor 3-d6. The contributions from the quaternary methyl group C18 were estimated by considering the differences between the VT (1)H T1 of mestranol 8 and methoxy-deuterated mestranol 8-d3. From these studies it was determined that the BCO rotator in 3 has an activation energy of only 1.15 kcal mol(-1), with a barrier for site exchange that is smaller than those of methyl (E(a) = 1.35 kcal mol(-1)) and methoxy groups (E(a) = 1.92 kcal mol(-1)), despite their smaller moments of inertia and surface areas.
[Mh] Termos MeSH primário: Compostos Bicíclicos com Pontes/química
[Mh] Termos MeSH secundário: Compostos Bicíclicos com Pontes/síntese química
Cristalografia por Raios X
Espectroscopia de Ressonância Magnética
Mestranol/química
Modelos Moleculares
Estrutura Molecular
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Bridged Bicyclo Compounds); B2V233XGE7 (Mestranol)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130626
[St] Status:MEDLINE
[do] DOI:10.1021/ja4024463


  5 / 2233 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22613036
[Au] Autor:Kovács D; Kádár Z; Mótyán G; Schneider G; Wölfling J; Zupkó I; Frank E
[Ad] Endereço:Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
[Ti] Título:Synthesis, characterization and biological evaluation of some novel 17-isoxazoles in the estrone series.
[So] Source:Steroids;77(11):1075-85, 2012 Sep.
[Is] ISSN:1878-5867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Regioselective 1,3-dipolar cycloadditions of different aryl nitrile oxides to mestranol were carried out to furnish novel steroidal 17α-isoxazoles in good to excellent yields. Copper(I) was found to be an efficient catalyst, accelerating the intermolecular ring-closures and leading exclusively to 3,5-disubstituted isoxazoles. The yields of the cycloadducts, however, were influenced by the substituents on the aromatic moiety of the 1,3-dipoles. Moreover, dehydration of the primary products resulted in the corresponding Δ(16,17)exo-heterocyclic derivatives. All the synthesized compounds were subjected to in vitro pharmacological studies of their antiproliferative effects relative to three human malignant cell lines (HeLa, MCF7 and A2780).
[Mh] Termos MeSH primário: Antineoplásicos/síntese química
Estrona/análogos & derivados
Estrona/síntese química
Isoxazóis/síntese química
[Mh] Termos MeSH secundário: Antineoplásicos/farmacologia
Catálise
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Cobre/química
Reação de Cicloadição
Ensaios de Seleção de Medicamentos Antitumorais
Estrona/farmacologia
Seres Humanos
Isoxazóis/farmacologia
Mestranol/química
Nitrilos/química
Óxidos/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Isoxazoles); 0 (Nitriles); 0 (Oxides); 2DI9HA706A (Estrone); 789U1901C5 (Copper); B2V233XGE7 (Mestranol)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120523
[St] Status:MEDLINE
[do] DOI:10.1016/j.steroids.2012.05.003


  6 / 2233 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:20024927
[Au] Autor:Vallejo A; Usobiaga A; Martinez-Arkarazo I; Prieto A; Etxebarria N; Zuloaga O; Fernández LA
[Ad] Endereço:Department of Analytical Chemistry, University of Basque Country, Bilbao, Spain. asier.vallejo@ehu.es
[Ti] Título:Ultrasonic-assisted derivatization of estrogenic compounds in a cup horn booster and determination by GC-MS.
[So] Source:J Sep Sci;33(1):104-11, 2010 Jan.
[Is] ISSN:1615-9314
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cup horn boosters are miniaturized ultrasound baths that maximize efficiency and precision. The optimization of an ultrasonic-assisted derivatization step by means of a cup horn booster and the determination of estrone, 17beta-estradiol, estriol, 17alpha-ethynyl estradiol and mestranol was developed by GC-MS. Different derivatization reagents and solvents were studied for maximizing the di-derivatization of 17alpha-ethynyl estradiol under ultrasound energy. Only N,O-bis(trimethylsilyl)trifluoroacetamide with 1% of trimethylchlorosilane in pyridine gave satisfactory results and this mixture was further used in the optimization of the ultrasound assisted derivatization. The experiment designs included sonication time (1-10 min), sonication power (20-80%), sonication cycles (1-9), derivatization reagent volume (25-125 microL) and solvent volume (25-125 microL). Once the optimum conditions were fixed, the effect of organic matter and the frequency of the water bath change were studied. Finally, the validation of the analytical method was carried out using spiked natural and synthetic waters. Recoveries (natural (138-70%) and synthetic (112-89%)), the LODs (0.35-1.66 ng/L), and LOQs (1.16-5.52 ng/L) and the precision (0.2-5.3%) of the method were studied. This is the first work in the literature where a cup horn booster is used with the aim of minimizing derivatization time during the determination of estrogenic compounds.
[Mh] Termos MeSH primário: Estrogênios/análise
Cromatografia Gasosa-Espectrometria de Massas
Ultrassom
[Mh] Termos MeSH secundário: Acetamidas/química
Animais
Estradiol/análise
Estriol/análise
Estrona/análise
Etinilestradiol/análise
Feminino
Cromatografia Gasosa-Espectrometria de Massas/instrumentação
Cromatografia Gasosa-Espectrometria de Massas/métodos
Seres Humanos
Indicadores e Reagentes/química
Masculino
Mestranol/análise
Solventes/química
Compostos de Trimetilsilil/química
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetamides); 0 (Estrogens); 0 (Indicators and Reagents); 0 (N,O-bis(trimethylsilyl)trifluoroacetamide); 0 (Solvents); 0 (Trimethylsilyl Compounds); 0 (Water Pollutants, Chemical); 2DI9HA706A (Estrone); 423D2T571U (Ethinyl Estradiol); 4TI98Z838E (Estradiol); 62UO4690X6 (trimethylchlorosilane); B2V233XGE7 (Mestranol); FB33469R8E (Estriol)
[Em] Mês de entrada:1004
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091222
[St] Status:MEDLINE
[do] DOI:10.1002/jssc.200900449


  7 / 2233 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:19443681
[Au] Autor:Schwartz J; Hunt T; Smith WB; Wong P; Larson P; Crumley T; Mehta A; Gottesdiener K; Agrawal N
[Ad] Endereço:Merck Research Laboratories, Rahway, NJ, USA.
[Ti] Título:The effect of etoricoxib on the pharmacokinetics of oral contraceptives in healthy participants.
[So] Source:J Clin Pharmacol;49(7):807-15, 2009 Jul.
[Is] ISSN:0091-2700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The pharmacokinetics of oral contraceptive (OC) components, ethinyl estradiol (EE) and norethindrone (NET), were evaluated after coadministration with etoricoxib in 3 double-blind, randomized, 2-period crossover studies of healthy women. There were 16, 39, and 24 participants enrolled in studies 1 (part I, part II), and 2, respectively. Each participant received triphasic OC (EE 35 microg/NET 0.5 mgx7 days, 0.75 mgx7 days, 1.0 mgx7 days) throughout each 28-day period. OC was coadministered with 21 days of etoricoxib daily followed by placebo for 7 days; the alternate period followed the reverse regimen (placebo to etoricoxib). Study 1 (part I) examined concurrent (morning) administration of OC/etoricoxib 120 mg, study 1 (part II) examined staggered (morning/night) administration of OC/etoricoxib 120 mg, and study 2 examined concurrent (morning) administration of OC/etoricoxib 60 mg. Coadministration of OC and etoricoxib 120 mg once daily was associated with a approximately 50% to 60% increase in EE concentrations, whereas etoricoxib 60 mg once daily was associated with a approximately 37% increase in EE concentrations. Coadministration of OC and etoricoxib was generally well tolerated. A clinically important change in NET AUC0-24 h was not observed. Adverse events included dyspepsia, diarrhea, headache, nausea, fatigue, loss of appetite, and taste disturbance.
[Mh] Termos MeSH primário: Anticoncepcionais Orais Combinados/administração & dosagem
Anticoncepcionais Orais Combinados/farmacocinética
Inibidores de Ciclo-Oxigenase/administração & dosagem
Mestranol/administração & dosagem
Mestranol/farmacocinética
Noretindrona/administração & dosagem
Noretindrona/farmacocinética
Piridinas/administração & dosagem
Piridinas/farmacologia
Sulfonas/administração & dosagem
Sulfonas/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anticoncepcionais Orais Combinados/efeitos adversos
Inibidores de Ciclo-Oxigenase/efeitos adversos
Inibidores de Ciclo-Oxigenase/farmacologia
Interações Medicamentosas
Feminino
Cefaleia/induzido quimicamente
Seres Humanos
Mestranol/efeitos adversos
Meia-Idade
Náusea/induzido quimicamente
Noretindrona/efeitos adversos
Piridinas/efeitos adversos
Albumina Sérica/metabolismo
Globulina de Ligação a Hormônio Sexual/metabolismo
Sulfonas/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Contraceptives, Oral, Combined); 0 (Cyclooxygenase Inhibitors); 0 (Pyridines); 0 (Serum Albumin); 0 (Sex Hormone-Binding Globulin); 0 (Sulfones); 8015-29-0 (Norinyl); B2V233XGE7 (Mestranol); T18F433X4S (Norethindrone); WRX4NFY03R (etoricoxib)
[Em] Mês de entrada:0909
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090516
[St] Status:MEDLINE
[do] DOI:10.1177/0091270009337131


  8 / 2233 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:18588602
[Au] Autor:Kawamura S; Sakai A; Endo T; Maruta M
[Ti] Título:Atypical depression as a premonitory symptom of migraine managed by an oral contraceptive.
[So] Source:Psychiatry Clin Neurosci;62(3):365, 2008 Jun.
[Is] ISSN:1440-1819
[Cp] País de publicação:Australia
[La] Idioma:eng
[Mh] Termos MeSH primário: Anticoncepcionais Orais Combinados/uso terapêutico
Transtorno Depressivo Maior/tratamento farmacológico
Mestranol/uso terapêutico
Enxaqueca com Aura/tratamento farmacológico
Noretindrona/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Alprazolam/envenenamento
Transtorno da Personalidade Borderline/tratamento farmacológico
Transtorno da Personalidade Borderline/psicologia
Bloqueadores dos Canais de Cálcio/uso terapêutico
Transtorno Depressivo Maior/diagnóstico
Transtorno Depressivo Maior/psicologia
Quimioterapia Combinada
Feminino
Seres Humanos
Enxaqueca com Aura/diagnóstico
Enxaqueca com Aura/psicologia
Piperazinas/uso terapêutico
Tentativa de Suicídio/psicologia
Ácido Valproico/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Calcium Channel Blockers); 0 (Contraceptives, Oral, Combined); 0 (Piperazines); 614OI1Z5WI (Valproic Acid); 8015-29-0 (Norinyl); B2V233XGE7 (Mestranol); DEE37CY4VO (lomerizine); T18F433X4S (Norethindrone); YU55MQ3IZY (Alprazolam)
[Em] Mês de entrada:0809
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080701
[St] Status:MEDLINE
[do] DOI:10.1111/j.1440-1819.2008.01808.x


  9 / 2233 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:18255111
[Au] Autor:Li H; Song Y; Peng X
[Ad] Endereço:Key Laboratory of Science & Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, PR China. hongqili@dhu.edu.cn
[Ti] Título:Improved synthesis of mestranol and ethinyl estradiol (EE) related degradation products as authentic references.
[So] Source:Steroids;73(5):488-94, 2008 May.
[Is] ISSN:0039-128X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Preparative chemical methods for the synthesis of 10 degradation or photodecomposition products of mestranol and ethinyl estradiol (EE) are described. The synthesized compounds are useful as reference materials and standards for pharmaceutical analysis of mestranol and EE as bulk chemical or in formulated product. New synthetic methods were presented and the known synthetic procedures were improved. Detailed structural characterization of the degradation or photodecomposition products of mestranol and EE and related compounds was reported.
[Mh] Termos MeSH primário: Estrogênios/síntese química
Etinilestradiol/síntese química
Mestranol/síntese química
[Mh] Termos MeSH secundário: Estrogênios/química
Etinilestradiol/química
Mestranol/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Estrogens); 423D2T571U (Ethinyl Estradiol); B2V233XGE7 (Mestranol)
[Em] Mês de entrada:0811
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080208
[St] Status:MEDLINE
[do] DOI:10.1016/j.steroids.2007.12.024


  10 / 2233 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:17455178
[Au] Autor:Sinkkonen J; Liimatainen J; Karonen M; Wiinamäki K; Eklund P; Sjöholm R; Pihlaja K
[Ad] Endereço:Laboratory of Organic Chemistry and Chemical Biology, Department of Chemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland. jari.sinkkonen@utu.fi
[Ti] Título:A sesquineolignan with a spirodienone structure from Pinus sylvestris L.
[So] Source:Angew Chem Int Ed Engl;46(22):4148-50, 2007.
[Is] ISSN:1433-7851
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Alcadienos/química
Lignanas/química
Mestranol/química
Noretinodrel/química
Pinus sylvestris/química
Compostos de Espiro/química
[Mh] Termos MeSH secundário: Produtos Biológicos/química
Estrogênios/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Progestinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkadienes); 0 (Biological Products); 0 (Estrogens); 0 (Lignans); 0 (Progestins); 0 (Spiro Compounds); 8015-30-3 (Infecundin); 88181ACA0M (Norethynodrel); B2V233XGE7 (Mestranol)
[Em] Mês de entrada:0708
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070425
[St] Status:MEDLINE



página 1 de 224 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde