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Pesquisa : D04.210.500.668.651.568.291.750 [Categoria DeCS]
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[PMID]:28223035
[Au] Autor:Chen Y; Su QQ; Liu QS
[Ad] Endereço:Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, 510260 Guangzhou, China.
[Ti] Título:Effects of quinestrol on the vocal behavior of mice during courtship interactions.
[So] Source:Physiol Behav;173:216-222, 2017 May 01.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vocalizations are a crucial part of courtship and mating in a wide variety of species. Mating behavior, including courtship calls, is modulated by sex steroid hormones. Male mice produce courtship ultrasonic vocalizations to attract females during heterosexual encounters. However, rare is the knowledge on whether vocal behavior of mice changes under sterilant treatment which will affect gonadal hormone levels. In the present study, we treat male mice with quinestrol, which interferes with the release of the gonadotropin-releasing hormone (GnRH) and has a significant anti-fertility effect in rodents. We compared the differences in the syllable structures (including peak intensity, peak frequency, duration, and bandwidth), total number of calls, and harmonic syllable proportions between quinestrol treated and control male mice. Male mice treated with quinestrol produced more courtship calls and more harmonic syllables than control mice, whereas the parameters of call syllables showed no significant change between the two groups. The results indicate that normal male vocal behavior during sexual interactions could be retained or even reinforced after quinestrol treatment. In addition, female mice approached male mice treated with quinestrol more than control mice, suggesting that the treated male mice were more attractive to the female mice than the controls. Thus, competitive reproductive interference is enhanced. Further, findings provided behavior mechanism in vocal context of the fertility control in mice.
[Mh] Termos MeSH primário: Corte
Estrogênios/farmacologia
Quinestrol/farmacologia
Comportamento Sexual Animal/efeitos dos fármacos
Vocalização Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Feminino
Masculino
Camundongos
Espectrografia do Som
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); JR0N7XD5GZ (Quinestrol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE


  2 / 165 MEDLINE  
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[PMID]:26171988
[Au] Autor:Li XF; Lin CB; Xie FR; Liang WG; Ji J; Yang Y
[Ad] Endereço:Department of Spinal Surgery, Guangxi Orthopaedics and Traumatology Hospital, Nanning, China.
[Ti] Título:Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats.
[So] Source:Am J Ther;23(6):e1630-e1636, 2016 Nov/Dec.
[Is] ISSN:1536-3686
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We aim to compare the effects of simvastatin and combination of simvastatin and nylestriol on bone metabolism in ovariectomized (OVX) rats. Fifty healthy Wistar female rats were randomly allocated into 5 groups: sham + saline group (group A), OVX + saline group (group B), OVX + simvastatin (5 mg·kg·d) (group C), OVX + nylestriol (0.01 mg·kg·d) (group D), and OVX + simvastatin (3 mg·kg·d) + nylestriol (0.005 mg·kg·d) (group E). All mice were orally administrated with saline or medicine dissolved in saline for 10 weeks. Body weight of rats before and after the experiment was measured. Twenty-four hours after the experiment, calcium (Ca), creatinine (Cr), and hydroxyproline in urine were detected. Serum levels of osteocalcin (bone Gla-protein, BGP) and alkaline phosphatase (ALP) were measured. Bone mineral density was detected and trabecular bone was observed after the isolation of femur and tibia. Remarkably decreased serum BGP and increased serum ALP levels were detected in group B compared with those in group A. However, notably increased serum BGP and decreased serum ALP levels were found in groups C, D, and E compared with those in group B; femoral and tibial bone mineral density decreased in group B compared with that in group A, but increased in groups C, D, and E compared with that in group B. Simvastatin and combination of simvastatin and nylestriol promote formation of new bone, increase bone density, and improve bone microstructure damage in OVX rats.
[Mh] Termos MeSH primário: Densidade Óssea/efeitos dos fármacos
Quinestrol/análogos & derivados
Sinvastatina/farmacologia
[Mh] Termos MeSH secundário: Fosfatase Alcalina/sangue
Animais
Cálcio/urina
Creatinina/urina
Quimioterapia Combinada
Feminino
Hidroxiprolina/urina
Osteocalcina/sangue
Ovariectomia
Quinestrol/administração & dosagem
Quinestrol/farmacologia
Distribuição Aleatória
Ratos
Ratos Wistar
Sinvastatina/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
104982-03-8 (Osteocalcin); 7JA3B3IALU (nylestriol); AGG2FN16EV (Simvastatin); AYI8EX34EU (Creatinine); EC 3.1.3.1 (Alkaline Phosphatase); JR0N7XD5GZ (Quinestrol); RMB44WO89X (Hydroxyproline); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150715
[St] Status:MEDLINE


  3 / 165 MEDLINE  
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[PMID]:25258304
[Au] Autor:Li J; Chen F; Chen Y; Wang Z
[Ad] Endereço:Laboratory of Veterinary Anatomy, College of Animal Science and Technology, Henan University of Science and Technology , Luoyang , China .
[Ti] Título:Mitochondrial- and Fas-L-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes.
[So] Source:Toxicol Mech Methods;24(9):609-15, 2014 Dec.
[Is] ISSN:1537-6524
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The pathways involved in quinestrol-induced spermatogenic apoptosis were studied in adult male rat by using daily intragastric administration of 0.01 mg/kg, 0.1 mg/kg and 1 mg/kg body weight quinestrol for two consecutive weeks. The immunohistochemistry staining was performed to measure the expression of proliferating cell nuclear antigen (PCNA), caspase-3, Bax, Bcl-2, Fas and FasL. The results showed that testes weights and the size of seminiferous tubule (ST) decreased as well as the organization of the ST changed significantly after treatment with 1 mg/kg quinestrol. The number of germ cells expressing caspase-3, Bax, Fas and FasL markedly increased whereas the numbers of cells expressing Bcl-2 and PCNA significantly decreased in the group treated with quinestrol at 1 mg/kg compared with the control. The results suggest that quinestrol induced abnormal spermatogenesis through the mitochondrial- and Fas-L-mediated pathways after quinestrol exposure in male rat.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Proteína Ligante Fas/metabolismo
Mitocôndrias/efeitos dos fármacos
Quinestrol/farmacologia
Espermatogênese/efeitos dos fármacos
Testículo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Masculino
Antígeno Nuclear de Célula em Proliferação/metabolismo
Ratos
Ratos Sprague-Dawley
Testículo/metabolismo
Testículo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (FASLG protein, human); 0 (Fas Ligand Protein); 0 (Proliferating Cell Nuclear Antigen); JR0N7XD5GZ (Quinestrol)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141124
[Lr] Data última revisão:
141124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140927
[St] Status:MEDLINE
[do] DOI:10.3109/15376516.2014.970680


  4 / 165 MEDLINE  
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[PMID]:25038589
[Au] Autor:Li J; Chen F; Li C; Chen Y
[Ad] Endereço:Laboratory of Veterinary Anatomy, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Laboratory of Veterinary Anatomy, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.
[Ti] Título:Quinestrol induces spermatogenic apoptosis in vivo via increasing pro-apoptotic proteins in adult male mice.
[So] Source:Tissue Cell;46(5):318-25, 2014 Oct.
[Is] ISSN:1532-3072
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:The effects of quinestrol on spermatogenesis were investigated in adult male mice by daily intragastric administration of quinestrol with various doses of 5, 10, 50 and 100mg/kg body weight for 10 days. The sperm counts declined while the number of abnormal spermatozoa went up in mice treated with quinestrol. The testicular weight and seminiferous tubular area gradually declined with increasing dosages of quinestrol to 50 and 100mg/kg. Rarefied germ cells showed irregular distributions in the seminiferous tubules of mice treated with 50 and 100mg/kg quinestrol. Apoptosis was highly pronounced in spermatogonia, spermatocytes, spermatids and Leydig cells. Antioxidant enzyme activities - superoxide dismutase and glutathione peroxidase - as well as total antioxidant capacity significantly reduced, while malondialdehyde contents increased. The number of germ cells expressing caspase-3, p53, Bax and FasL significantly increased whereas cells expressing Bcl-2 significantly decreased in groups treated with 50 and 100mg/kg quinestrol compared with the control. The concentration of nitrogen monoxidum also increased significantly under these dosages. The results suggest that quinestrol stimulates oxidative stress to induce apoptosis in spermatogenic cells through the mitochondrial and death receptor pathways in adult male mice.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Estrogênios/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Quinestrol/farmacologia
Espermatozoides/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Proteínas Reguladoras de Apoptose/efeitos dos fármacos
Proteínas Reguladoras de Apoptose/metabolismo
Imuno-Histoquímica
Masculino
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Apoptosis Regulatory Proteins); 0 (Estrogens); JR0N7XD5GZ (Quinestrol)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141014
[Lr] Data última revisão:
141014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140721
[St] Status:MEDLINE


  5 / 165 MEDLINE  
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[PMID]:24997302
[Au] Autor:Geng Q; Li P; Zhang W; Deng Y; Duan Y; Cao Y
[Ad] Endereço:College of Agriculture and Biotechnology, China Agricultural University, Beijing, China.
[Ti] Título:The bioaccumulation and biotransformation of synthetic estrogen quinestrol in crucian carp.
[So] Source:Aquat Toxicol;155:84-90, 2014 Oct.
[Is] ISSN:1879-1514
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The occurrence and fate of endocrine disrupting chemicals (EDCs) in aquatic species have attracted close attention during the last decades. In this study, the bioaccumulation and biotransformation of synthetic estrogen quinestrol, one of the typical EDCs, in the plasma and liver of crucian carp, were investigated by a newly developed and validated reversed-phase high performance liquid chromatography with fluorescent detection method. Crucian carp were exposed to quinestrol in concentration of 2, 10, 50, 100 µg/L (5.49, 27.43, 137.17, 274.34 nmol/L) for 60 days. After 60 days' exposure, the concentrations of quinestrol found in liver and plasma were in the range of 0.25-0.69 mg/kg and 0.19-0.30 mg/L respectively, positively correlated with the exposure concentrations ranged 2-100 µg/L (5.49-274.34 nmol/L). There was a negative correlation between the bio-accumulation ratios and the exposure concentrations of quinestrol. 17α-Ethinylestradiol was also found in liver and plasma, and the concentrations were 0.02-0.19 mg/kg and 0.37-0.96 mg/L, respectively. The results indicated that quinestrol can be accumulated and transformed to 17α-ethinylestradiol in crucian carp. Moreover, exposure to quinestrol caused oxidative damages to crucian carp and the content of malondialdehyde increased in all treatment concentrations.
[Mh] Termos MeSH primário: Disruptores Endócrinos/metabolismo
Estrogênios/toxicidade
Quinestrol/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Carpas/metabolismo
Relação Dose-Resposta a Droga
Estrogênios/administração & dosagem
Estrogênios/metabolismo
Etinilestradiol/metabolismo
Fígado/metabolismo
Malondialdeído/metabolismo
Quinestrol/administração & dosagem
Quinestrol/metabolismo
Poluentes Químicos da Água/administração & dosagem
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Estrogens); 0 (Water Pollutants, Chemical); 423D2T571U (Ethinyl Estradiol); 4Y8F71G49Q (Malondialdehyde); JR0N7XD5GZ (Quinestrol)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140818
[Lr] Data última revisão:
140818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140706
[St] Status:MEDLINE


  6 / 165 MEDLINE  
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[PMID]:24565896
[Au] Autor:Liu YR; Huang RQ; Xiao BK; Yang JY; Dong JX
[Ad] Endereço:School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Rd, Shenhe District, Shenyang 110016, PR China; Beijing Institute of Radiation Medicine, No. 27, Taiping Road, Haidian District, Beijing 100850, PR China.
[Ti] Título:(1)H NMR metabolic profiling analysis offers evaluation of Nilestriol treatment in ovariectomised rats.
[So] Source:Mol Cell Endocrinol;387(1-2):19-34, 2014 Apr 25.
[Is] ISSN:1872-8057
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Nilestriol (NIL) has been applied to treat menopausal dysfunctions, yet its mechanism has remained unknown. To understand the relationship between the changes in homeostatic metabolites and ovarian oestrogen deficiency syndromes after NIL treatment, proton Nuclear Magnetic Resonance ((1)H NMR)-based metabonomic technologies were used to analyse a rat model of oestrogen deficiency. An orthogonal partial least-squares regression (OPLS) differentiation model was used on 12-week metabolic analyses of ovariectomised (OVX) rats treated or mock treated with NIL. Furthermore, data analysis using Chenomx software quantified results to identify the most significantly altered metabolite concentrations, allowing for metabolic explanations of the effects of NIL therapies. In this study, PLS results revealed that there are considerably distinct differences between treatment groups. Additionally, a total of 45 metabolites shown to have a high variation between groups were selected for target quantification. Using a one-way LSD ANOVA analysis, 32 metabolite concentrations were significantly altered in the OVX group. A total of 21 metabolites were altered significantly in the NIL-treatment group but later returned to normal. According to the OPLS VIP calculation, the metabolites most affected by NIL treatment were mostly involved in insulin resistance. In addition, abnormal concentration changes in lactate in the NIL-treatment group and 3-indoxylsulfate in the OVX group were observed. To our knowledge, this study is the first to address the molecular mechanism of NIL from a metabonomic perspective, and, more specifically, to establish a catalogue of endo-molecular changes effected by NIL in the regulation of oestrogen deficiency disorder.
[Mh] Termos MeSH primário: Estriol/análogos & derivados
Menopausa/efeitos dos fármacos
Metaboloma/fisiologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Estriol/farmacologia
Feminino
Indicã/análise
Resistência à Insulina
Ácido Láctico/análise
Metabolômica
Ressonância Magnética Nuclear Biomolecular
Ovariectomia
Quinestrol/análogos & derivados
Ratos
Ratos Sprague-Dawley
Soro/química
Urina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
33X04XA5AT (Lactic Acid); 7JA3B3IALU (nylestriol); FB33469R8E (Estriol); JR0N7XD5GZ (Quinestrol); N187WK1Y1J (Indican)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140226
[St] Status:MEDLINE


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[PMID]:24183492
[Au] Autor:Li J; Wang H; Zhang J; Zhou B; Si L; Wei L; Li X
[Ad] Endereço:College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471000, China. Electronic address: lijian800702@126.com.
[Ti] Título:Abnormal secretion of reproductive hormones and antioxidant status involved in quinestrol-induced reproductive toxicity in adult male rat.
[So] Source:Tissue Cell;46(1):27-32, 2014 Feb.
[Is] ISSN:1532-3072
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate the effects of quinestrol, a synthetic oestrogen homologue with reproductive toxicity, on the secretion of reproductive hormones and antioxidant status in adult male rat. Our results showed that quinestrol exposure significantly decreased the weight of the testis, epididymides, seminal vesicle, and prostate, as well as the sperm counts in the cauda epididymis of rats. Quinestrol significantly reduced the size of seminiferous tubules and the total number of spermatogenic cells. Serum testosterone, follitropin, and lutropin were also significantly reduced in a dose-related manner after quinestrol exposure. Meanwhile, the activity of superoxide dismutase, glutathione peroxidase, and total antioxide capacity significantly decreased, whereas the malondialdehyde and nitric oxide concentrations significantly increased in the testes. These findings revealed that endocrine disorders of reproductive hormones and oxidative stress may be involved in reproductive toxicity induced by quinestrol in adult male rats.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Quinestrol/toxicidade
Reprodução/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
Testosterona/secreção
[Mh] Termos MeSH secundário: Envelhecimento
Animais
Epididimo/efeitos dos fármacos
Glutationa Peroxidase/metabolismo
Masculino
Ratos
Ratos Sprague-Dawley
Testículo/efeitos dos fármacos
Testículo/secreção
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 3XMK78S47O (Testosterone); EC 1.11.1.9 (Glutathione Peroxidase); JR0N7XD5GZ (Quinestrol)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140210
[Lr] Data última revisão:
140210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131105
[St] Status:MEDLINE


  8 / 165 MEDLINE  
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[PMID]:23818077
[Au] Autor:Zhang Q; Wang C; Liu W; Qu J; Liu M; Zhang Y; Zhao M
[Ad] Endereço:College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China.
[Ti] Título:Degradation of the potential rodent contraceptive quinestrol and elimination of its estrogenic activity in soil and water.
[So] Source:Environ Sci Pollut Res Int;21(1):652-9, 2014 Jan.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Quinestrol has shown potential for use in the fertility control of the plateau pika population of the Qinghai-Tibet Plateau. However, the environmental safety and fate of this compound are still obscure. Our study investigated degradation of quinestrol in a local soil and aquatic system for the first time. The results indicate that the degradation of quinestrol follows first-order kinetics in both soil and water, with a dissipation half-life of approximately 16.0 days in local soil. Microbial activity heavily influenced the degradation of quinestrol, with 41.2% removal in non-sterile soil comparing to 4.8% removal in sterile soil after incubation of 10 days. The half-lives in neutral water (pH 7.4) were 0.75 h when exposed to UV light (λ = 365 nm) whereas they became 2.63 h when exposed to visible light (λ > 400 nm). Acidic conditions facilitated quinestrol degradation in water with shorter half-lives of 1.04 and 1.47 h in pH 4.0 and pH 5.0 solutions, respectively. Moreover, both the soil and water treatment systems efficiently eliminated the estrogenic activity of quinestrol. Results presented herein clarify the complete degradation of quinestrol in a relatively short time. The ecological and environmental safety of this compound needs further investigation.
[Mh] Termos MeSH primário: Anticoncepcionais Orais/química
Poluentes Ambientais/química
Quinestrol/química
Solo/química
[Mh] Termos MeSH secundário: Animais
Anticoncepcionais Orais/análise
Poluentes Ambientais/análise
Água Doce/química
Meia-Vida
Cinética
Quinestrol/análise
Controle de Roedores/métodos
Roedores
Tibet
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contraceptives, Oral); 0 (Environmental Pollutants); 0 (Soil); JR0N7XD5GZ (Quinestrol)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130703
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-013-1941-1


  9 / 165 MEDLINE  
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[PMID]:24020466
[Au] Autor:Fu H; Zhang J; Shi D; Wu X
[Ad] Endereço:China Agricultural University, Beijing, China Inner Mongolia Agricultural University, Hohhot, China Key Laboratory of Prataculture and Grassland Resources of Education Ministry, Hohhot, China.
[Ti] Título:Effects of levonorgestrel-quinestrol (EP-1) treatment on Mongolian gerbil wild populations: a case study.
[So] Source:Integr Zool;8(3):277-84, 2013 Sep.
[Is] ISSN:1749-4877
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Rodent pest population outbreaks occur frequently in grassland ecosystems in northern China. The Mongolian gerbil (Meriones unguiculatus) is a dominant pest rodent which is distributed across the semi-desert grasslands of Inner Mongolia, China. In 2009, we studied the contraceptive effect of levonorgestrel-quinestrol (EP-1), concentration 50 ppm, on a wild Mongolian gerbil population. The one-off contraceptive treatment was compared with a control group using a semi-monthly live trapping method in the Ordos Semi-desert Grassland Region of Inner Mongolia. The results show that juveniles were not recruited in spring in the treatment group. Ratios of juveniles in the control and treatment groups showed significant semi-monthly differences from spring to summer (one-way ANOVA, F2, 14 = 7.53, P < 0.05). Between both groups, annual fluctuations of juvenile and total population densities were significantly different respectively (F2, 14 = 4.64, P < 0.05; F2, 18 = 7.72, P < 0.05). The contraceptive EP-1 delayed the normal reproductive pattern of Mongolian gerbil populations. This suppressed birth rates of gerbil populations, reduced their densities, and changed their age structures. The period of EP-1 baiting should be extended but it could be an ideal method for controlling Mongolian gerbil populations during each breeding season.
[Mh] Termos MeSH primário: Anticoncepcionais Orais Sintéticos/farmacologia
Fertilidade/efeitos dos fármacos
Gerbillinae/fisiologia
Levanogestrel/farmacologia
Quinestrol/farmacologia
Controle de Roedores/métodos
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Estudos de Casos e Controles
China
Densidade Demográfica
Dinâmica Populacional
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contraceptives, Oral, Synthetic); 5W7SIA7YZW (Levonorgestrel); JR0N7XD5GZ (Quinestrol)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:130911
[Lr] Data última revisão:
130911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130912
[St] Status:MEDLINE
[do] DOI:10.1111/1749-4877.12018


  10 / 165 MEDLINE  
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[PMID]:23153699
[Au] Autor:Lv X; Guo Y; Shi D
[Ad] Endereço:College of Agriculture and Biotechnology, China Agricultural University, Beijing, China.
[Ti] Título:Effects of quinestrol and levonorgestrel on prolactin serum concentration in lactating Mongolian gerbils (Meriones unguiculatus) and reproductive parameters of their offspring.
[So] Source:Reprod Biol;12(3):285-92, 2012 Nov.
[Is] ISSN:2300-732X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The effects of the two sterilants, quinestrol (QE) and levonorgestrel (LNG) on serum prolactin (PRL) level in lactating Mongolian gerbils and reproductive parameters of their offspring were examined in the study. Both sterilants increased the serum PRL level in lactating gerbils. The body weight as well as weights of the ovary, testis, epididymides, and seminal vesicles were lower, whereas that of the uterus was higher in the pups originating from QE-treated mothers in comparison to controls. Histological ovarian sections of the offspring from QE-treated mothers contained only growing follicles, whereas their uterine sections showed a thinner endometrium, thicker myometrium, and greater epithelial-cell height than in controls. The histometrical testis characteristics as well as sperm concentration and motility of male pups from QE-treated mothers were lower compared to those of the control group. The serum gonadotropin levels of female pups from mothers treated with QE were lower, whereas the serum estradiol (E(2)) and progesterone (P(4)) levels were higher than in control gerbils. In contrast, serum gonadotropin and testosterone (T) levels of male pups from QE-treated mothers were lower compared to controls. LNG did not affect the examined parameters of the offspring. The offspring from QE-treated mothers was infertile, whereas the offspring from LNG-treated mothers was fertile. In summary, QE and LNG have a stimulatory effect on PRL level in lactating gerbils. It also appears that QE administered via milk to mothers affects reproductive processes of their offspring.
[Mh] Termos MeSH primário: Lactação/sangue
Levanogestrel/farmacologia
Prolactina/sangue
Quinestrol/farmacologia
Reprodução/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anticoncepcionais Femininos/farmacologia
Estrogênios/farmacologia
Feminino
Fertilidade
Gerbillinae
Lactação/fisiologia
Masculino
Ovário/efeitos dos fármacos
Ovário/crescimento & desenvolvimento
Gravidez
Reprodução/fisiologia
Testículo/efeitos dos fármacos
Testículo/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contraceptive Agents, Female); 0 (Estrogens); 5W7SIA7YZW (Levonorgestrel); 9002-62-4 (Prolactin); JR0N7XD5GZ (Quinestrol)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:151029
[Lr] Data última revisão:
151029
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121117
[St] Status:MEDLINE



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