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[PMID]:23851484
[Au] Autor:Bauer CT; Banks ML; Blough BE; Negus SS
[Ad] Endereço:Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
[Ti] Título:Rate-dependent effects of monoamine releasers on intracranial self-stimulation in rats: implications for abuse liability assessment.
[So] Source:Behav Pharmacol;24(5-6):448-58, 2013 Sep.
[Is] ISSN:1473-5849
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:'Rate dependency' in the discipline of behavioral pharmacology describes a phenomenon wherein the effect of a drug on the rate of a behavior varies systematically as a function of the baseline, predrug rate of that behavior. Historically, rate-dependency studies have compared drug effects on different baseline rates of behavior maintained either by different schedules of reinforcement or during sequential segments of a fixed-interval schedule. The current experiment generated different baseline rates of behavior by altering frequency of electrical stimulation in an intracranial self-stimulation assay. Amphetamine and 10 other monoamine releasers were analyzed for their ability to produce rate-dependent effects in this assay. There were three main findings. First, all compounds produced rate-dependent effects at some dose. Second, one parameter of rate-dependency plots (peak Y-intercept of the regression line) correlated with in-vitro neurochemical data on selectivity of these compounds to release dopamine versus serotonin (P<0.025, R=0.50). Lastly, a correlation between peak Y-intercept and breakpoints under a progressive-ratio procedure in nonhuman primates was also significant (P<0.05, R=0.64). Overall, these results extend the rate-dependent effects of monoamine releasers to behavior maintained under intracranial self-stimulation and suggest that, at least for monoamine releasers, the Y-intercept parameter of rate-dependency plots might be a useful metric of drug reward and predictor of drug self-administration measures of drug reinforcement.
[Mh] Termos MeSH primário: Monoaminas Biogênicas/metabolismo
Esquema de Reforço
Autoestimulação/fisiologia
[Mh] Termos MeSH secundário: Anfetamina/farmacologia
Animais
Estimulantes do Sistema Nervoso Central/farmacologia
Dopamina/metabolismo
Relação Dose-Resposta a Droga
Fenfluramina/administração & dosagem
Masculino
Feixe Prosencefálico Mediano/efeitos dos fármacos
Feixe Prosencefálico Mediano/fisiologia
Metanfetamina/farmacologia
Noretandrolona/metabolismo
Ratos
Ratos Sprague-Dawley
Análise de Regressão
Autoestimulação/efeitos dos fármacos
Serotonina/metabolismo
Inibidores da Captação de Serotonina/administração & dosagem
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Biogenic Monoamines); 0 (Central Nervous System Stimulants); 0 (Serotonin Uptake Inhibitors); 2DS058H2CF (Fenfluramine); 333DO1RDJY (Serotonin); 44RAL3456C (Methamphetamine); CK833KGX7E (Amphetamine); P7W01638W6 (Norethandrolone); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130716
[St] Status:MEDLINE
[do] DOI:10.1097/FBP.0b013e328363d1a4


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[PMID]:22833045
[Au] Autor:Grünblatt E; Bartl J; Marinova Z; Walitza S
[Ad] Endereço:Department of Child and Adolescent Psychiatry, University of Zurich, Neumuensterallee 9, 8032, Zurich, Switzerland. edna.gruenblatt@kjpdzh.ch
[Ti] Título:In vitro study methodologies to investigate genetic aspects and effects of drugs used in attention-deficit hyperactivity disorder.
[So] Source:J Neural Transm (Vienna);120(1):131-9, 2013 Jan.
[Is] ISSN:1435-1463
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Attention-deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children and adolescents, with up to 5 % affected worldwide. Twin and family studies on ADHD show its high familiality with heritability estimated around 70 %, but, to date, no specific polymorphism or gene was found to be specifically affected. Psychostimulants (amphetamine, methylphenidate) and non-psychostimulants (atomoxetine) are used successfully in ADHD therapy, but many of their mechanisms of action and their adverse effects are not yet fully understood. Therefore, both genetic findings and therapeutic interventions should be further investigated. One easy platform for such studies is in vitro analyses, which encompass neuronal cell culture studies, transfections of genetic constructs, binding and electrophysiology analyses. In this review, different methods will be referred in particular to ADHD findings, and new techniques will be mentioned for future studies of drug or genetic effects in vitro.
[Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico
Transtorno do Deficit de Atenção com Hiperatividade/genética
Estimulantes do Sistema Nervoso Central/uso terapêutico
Regulação da Expressão Gênica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Estimulantes do Sistema Nervoso Central/farmacologia
Dopamina/metabolismo
Proteínas da Membrana Plasmática de Transporte de Dopamina/genética
Proteínas da Membrana Plasmática de Transporte de Dopamina/metabolismo
Regulação da Expressão Gênica/genética
Seres Humanos
Proteínas da Membrana Plasmática de Transporte de Norepinefrina/genética
Proteínas da Membrana Plasmática de Transporte de Norepinefrina/metabolismo
Noretandrolona/metabolismo
Polimorfismo Genético/genética
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 0 (Dopamine Plasma Membrane Transport Proteins); 0 (Norepinephrine Plasma Membrane Transport Proteins); P7W01638W6 (Norethandrolone); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1306
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120727
[St] Status:MEDLINE
[do] DOI:10.1007/s00702-012-0869-9


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[PMID]:20689910
[Au] Autor:Georger JF; Hamzaoui O; Chaari A; Maizel J; Richard C; Teboul JL
[Ad] Endereço:Service de réanimation médicale, Centre Hospitalo-Universitaire de Bicêtre, Assistance Publique-Hôpitaux de Paris, EA 4046, Université Paris Sud, Le Kremlin-Bicêtre, France. jean-louis.teboul@bct.aphp.fr
[Ti] Título:Restoring arterial pressure with norepinephrine improves muscle tissue oxygenation assessed by near-infrared spectroscopy in severely hypotensive septic patients.
[So] Source:Intensive Care Med;36(11):1882-9, 2010 Nov.
[Is] ISSN:1432-1238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To examine the consequences of administration of norepinephrine on muscle tissue oxygenation in severely hypotensive septic shock patients. METHODS: This was a prospective observational study conducted in a medical intensive care unit of a university hospital. We included 28 septic shock patients that received early volume resuscitation. All were eligible for receiving norepinephrine because of life-threatening hypotension and low diastolic arterial pressure. Muscle tissue oxygen saturation (StO2) and its changes during a vascular occlusion test were measured at the level of the thenar eminence using a near-infrared spectroscopy (NIRS) device. Transpulmonary thermodilution cardiac index (CI) and NIRS-derived variables were obtained before and after the mean arterial pressure (MAP) was increased by norepinephrine. The baseline StO2 and the vascular occlusion test-derived variables of 17 healthy volunteers were measured and served as controls. RESULTS: In healthy volunteers, StO2 ranged between 75 and 90% and StO2 recovery slopes ranged between 1.5 and 3.4%/s. Administration of norepinephrine, which was associated with an increase in MAP from 54 ± 8 to 77 ± 9 mmHg (p < 0.05), also induced increases in CI from 3.14 ± 1.03 to 3.61 ± 1.28 L/min/m² (p < 0.05), in StO2 from 75 ± 9 to 78 ± 9% (p < 0.05) and in StO2 recovery slope from 1.0 ± 0.6 to 1.5 ± 0.7%/s (p < 0.05). CONCLUSIONS: Norepinephrine administration aimed at achieving a MAP higher than 65 mmHg in septic shock patients with life-threatening hypotension resulted in improvement of NIRS variables measured at the level of the thenar eminence.
[Mh] Termos MeSH primário: Anabolizantes/uso terapêutico
Artérias/fisiologia
Hipotensão/tratamento farmacológico
Músculo Esquelético/irrigação sanguínea
Noretandrolona/uso terapêutico
Consumo de Oxigênio/efeitos dos fármacos
Choque Séptico/fisiopatologia
Espectroscopia de Luz Próxima ao Infravermelho
[Mh] Termos MeSH secundário: Adulto
Idoso
Anabolizantes/administração & dosagem
Feminino
Hospitais Universitários
Seres Humanos
Masculino
Microcirculação/fisiologia
Meia-Idade
Monitorização Fisiológica
Noretandrolona/administração & dosagem
Estudos Prospectivos
Índice de Gravidade de Doença
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); P7W01638W6 (Norethandrolone)
[Em] Mês de entrada:1102
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100807
[St] Status:MEDLINE
[do] DOI:10.1007/s00134-010-2013-3


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[PMID]:19577611
[Au] Autor:Nater UM; Whistler T; Lonergan W; Mletzko T; Vernon SD; Heim C
[Ad] Endereço:Chronic Viral Diseases Branch, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control & Prevention, 1600 Clifton Rd, MS-G41, Atlanta, GA 30329, USA.
[Ti] Título:Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men.
[So] Source:Biol Psychol;82(2):125-32, 2009 Oct.
[Is] ISSN:1873-6246
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We investigated peripheral blood mononuclear cell gene expression responses to acute psychosocial stress to identify molecular pathways relevant to the stress response. Blood samples were obtained from 10 healthy male subjects before, during and after (at 0, 30, and 60 min) a standardized psychosocial laboratory stressor. Ribonucleic acid (RNA) was extracted and gene expression measured by hybridization to a 20,000-gene microarray. Gene Set Expression Comparisons (GSEC) using defined pathways were used for the analysis. Forty-nine pathways were significantly changed from baseline to immediately after the stressor (p<0.05), implicating cell cycle, cell signaling, adhesion and immune responses. The comparison between stress and recovery (measured 30 min later) identified 36 pathways, several involving stress-responsive signaling cascades and cellular defense mechanisms. These results have relevance for understanding molecular mechanisms of the physiological stress response, and might be used to further study adverse health outcomes of psychosocial stress.
[Mh] Termos MeSH primário: Expressão Gênica/fisiologia
Leucócitos Mononucleares/metabolismo
Estresse Psicológico
[Mh] Termos MeSH secundário: Hormônio Adrenocorticotrópico/sangue
Adulto
Perfilação da Expressão Gênica/métodos
Seres Humanos
Hidrocortisona/sangue
Interleucina-6/sangue
Masculino
Meia-Idade
Noretandrolona/sangue
Análise de Sequência com Séries de Oligonucleotídeos/métodos
Psicometria/métodos
Transdução de Sinais/fisiologia
Estresse Psicológico/sangue
Estresse Psicológico/metabolismo
Estresse Psicológico/fisiopatologia
Fatores de Tempo
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Interleukin-6); 0 (Transcription Factors); 9002-60-2 (Adrenocorticotropic Hormone); P7W01638W6 (Norethandrolone); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:0911
[Cu] Atualização por classe:150326
[Lr] Data última revisão:
150326
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090707
[St] Status:MEDLINE
[do] DOI:10.1016/j.biopsycho.2009.06.009


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[PMID]:19027274
[Au] Autor:Fanton L; Belhani D; Vaillant F; Tabib A; Gomez L; Descotes J; Dehina L; Bui-Xuan B; Malicier D; Timour Q
[Ad] Endereço:Institute of Forensic Medicine, Claude Bernard University, Lyon, France.
[Ti] Título:Heart lesions associated with anabolic steroid abuse: comparison of post-mortem findings in athletes and norethandrolone-induced lesions in rabbits.
[So] Source:Exp Toxicol Pathol;61(4):317-23, 2009 Jul.
[Is] ISSN:1618-1433
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Among 15,000 forensic post-mortem examinations performed on the coroner's order over a 24-year period (January 1981-December 2004) in the area of Lyon, France (population: 2,000,000), 2250 cases of unexpected cardiac sudden death were identified retrospectively according to WHO criteria. Of these, 108 occurred during recreational sport and 12 occurred in athletes. In the latter category, a history of anabolic steroid abuse was found in 6 cases, whereas pre-existing ordinary cardiac lesions were observed in the 6 remaining cases. To shed light on the possible role of anabolic steroids in the induction of cardiac lesions, an experimental study was conducted in rabbits that were treated orally with norethandrolone 8mg/kg/day for 60 days, and sacrificed at day 90. The histopathological examination of the heart from treated animals showed coronary thrombosis associated with left ventricle hypertrophy in 3 cases, and lesions analogous to toxic or adrenergic myocarditis in all other treated animals. These findings were very similar to those observed after cardiac sudden death in the 6 athletes with a history of anabolic steroid abuse. In addition, elevated caspase-3 activity in the heart of treated rabbits as compared to controls suggests that apoptosis is involved in the induction of norethandrolone-induced cardiac lesions. These results confirm the cardiotoxic potential of anabolic steroid abuse.
[Mh] Termos MeSH primário: Anabolizantes/efeitos adversos
Morte Súbita Cardíaca/etiologia
Cardiopatias/induzido quimicamente
Miocárdio/patologia
Noretandrolona/efeitos adversos
Esportes
[Mh] Termos MeSH secundário: Adulto
Animais
Morte Súbita Cardíaca/patologia
Feminino
Patologia Legal
Cardiopatias/patologia
Seres Humanos
Masculino
Meia-Idade
Coelhos
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); P7W01638W6 (Norethandrolone)
[Em] Mês de entrada:0910
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081126
[St] Status:MEDLINE
[do] DOI:10.1016/j.etp.2008.09.007


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[PMID]:17687262
[Au] Autor:Billes SK; Cowley MA
[Ad] Endereço:Division of Neuroscience, Oregon National Primate Research Center/Oregon Health and Science University, Beaverton, OR 97006, USA.
[Ti] Título:Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis.
[So] Source:Neuropsychopharmacology;33(6):1287-97, 2008 May.
[Is] ISSN:0893-133X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bupropion (BUP) is a dopamine (DA) and norepinephrine (NE) reuptake inhibitor that causes mild weight loss in obese adults. Subchronic (7 day) coadministration of selective DA and NE reuptake inhibitors also causes weight loss in mice. Because weight loss was not associated with decreased caloric intake, subchronic BUP might cause weight loss through increased energy expenditure. Acute studies demonstrate that BUP or DA+NE reuptake inhibitors cause transient hypophagia and increased locomotion; though the effects on temperature are inconsistent. Because subchronic DA+NE reuptake inhibition does not affect appetite, there is clearly a difference between the acute and subchronic effects of DA+NE reuptake inhibitors; however the effects of chronic (or subchronic) BUP on energy balance have never been directly studied in an animal model. Therefore, the acute and subchronic effects of BUP or selective DA and NE reuptake inhibitors on food intake, body weight, locomotor activity, and interscapular temperature were determined in mice. Generally, selective inhibition of DA reuptake (by GBR12783) increased activity while selective inhibition of NE reuptake (by nisoxetine, NIS) decreased activity and temperature. BUP increased activity and temperature but subchronic BUP did not significantly reduce body weight due to a compensatory increase in food intake. Subchronic DA+NE reuptake inhibitor coadministration mimicked the effect of BUP on activity and temperature, but caused weight loss because daily food intake was not increased. The results of this study suggest that the mild weight loss effect of BUP in humans may be due to increased locomotion or heat production. More importantly, inhibition of DA+NE reuptake (with GBR+NIS) increased energy expenditure without a compensatory increase in food intake, supporting a role for novel combination catecholamine reuptake inhibitors in pharmacotherapy for obesity.
[Mh] Termos MeSH primário: Catecolaminas/metabolismo
Atividade Motora/fisiologia
Termogênese/fisiologia
Perda de Peso/fisiologia
[Mh] Termos MeSH secundário: Animais
Área Sob a Curva
Comportamento Animal/efeitos dos fármacos
Comportamento Animal/fisiologia
Bupropiona/farmacologia
Inibidores da Captação de Dopamina/farmacologia
Relação Dose-Resposta a Droga
Esquema de Medicação
Ingestão de Alimentos/efeitos dos fármacos
Fluoxetina/análogos & derivados
Fluoxetina/farmacologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Atividade Motora/efeitos dos fármacos
Norepinefrina/metabolismo
Noretandrolona/antagonistas & inibidores
Noretandrolona/metabolismo
Piperazinas/farmacologia
Telemetria
Termogênese/efeitos dos fármacos
Fatores de Tempo
Perda de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Catecholamines); 0 (Dopamine Uptake Inhibitors); 0 (Piperazines); 01K63SUP8D (Fluoxetine); 01ZG3TPX31 (Bupropion); 17NV064B2D (nisoxetine); 67469-57-2 (1-(2-(diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine); P7W01638W6 (Norethandrolone); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:0808
[Cu] Atualização por classe:150311
[Lr] Data última revisão:
150311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070810
[St] Status:MEDLINE


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[PMID]:17887801
[Au] Autor:Kaklamanos G; Theodoridis G; Papadoyannis IN; Dabalis T
[Ad] Endereço:Veterinary Laboratory of Serres, Terma Omonoias, 62110 Serres, Greece.
[Ti] Título:Determination of anabolic steroids in muscle tissue by liquid chromatography-tandem mass spectrometry.
[So] Source:J Agric Food Chem;55(21):8325-30, 2007 Oct 17.
[Is] ISSN:0021-8561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A specific and sensitive method based on liquid chromatography-tandem mass spectrometry using atmospheric pressure chemical ionization (LC-APCI-MS/MS) has been developed for the determination of four anabolic steroids [trenbolone, methylboldenone, methyltestosterone, and norethandrolone] in bovine muscle. Methyltestosterone- d 3 was used as internal standard. The procedure involved enzymatic hydrolysis, extraction with tert-butyl methyl ether, defattening, and final cleanup with solid-phase extraction with Oasis HLB cartridges. The analytes were analyzed by reversed-phase LC-MS/MS, acquiring two diagnostic product ions from the chosen precursor [M + H] (+) for the unambiguous confirmation of hormones. The method was validated according to the European Commission Decision 2002/657/EC for the detection and confirmation of residues in products of animal origin. The limits of detection (LOD) and limits of quantitation (LOQ) were found to be 0.3 ng/g and 1.0 ng/g, respectively. The accuracy and precision have been determined, with recoveries ranging from 83% to 104% and the CV factor not exceeding the value of 7%. The decision limits CCalpha were calculated and ranged from 0.05 to 0.15 ng/g while the detection capabilities CCbeta ranged from 0.09 to 0.25 ng/g. The method proved to be sensitive and reliable and thus renders an appropriate means for residue analysis studies.
[Mh] Termos MeSH primário: Anabolizantes/análise
Cromatografia Líquida de Alta Pressão
Espectrometria de Massas
Músculos/química
[Mh] Termos MeSH secundário: Animais
Bovinos
Feminino
Masculino
Metiltestosterona/análise
Noretandrolona/análise
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Testosterona/análogos & derivados
Testosterona/análise
Acetato de Trembolona/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); 3XMK78S47O (Testosterone); 5H7I2IP58X (boldenone); P7W01638W6 (Norethandrolone); RUD5Y4SV0S (Trenbolone Acetate); V9EFU16ZIF (Methyltestosterone)
[Em] Mês de entrada:0711
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070925
[St] Status:MEDLINE


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[PMID]:16183083
[Au] Autor:Kim DK; Tolliver TJ; Huang SJ; Martin BJ; Andrews AM; Wichems C; Holmes A; Lesch KP; Murphy DL
[Ad] Endereço:Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.
[Ti] Título:Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter.
[So] Source:Neuropharmacology;49(6):798-810, 2005 Nov.
[Is] ISSN:0028-3908
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To evaluate the consequences of inactivation of the serotonin transporter (SERT) gene on 5-HT homeostasis and function, 5-HT synthesis and turnover rates were measured using the decarboxylase inhibition method in multiple brain regions (frontal cortex, striatum, brainstem, hippocampus and hypothalamus) from mice with a genetic disruption of SERT. 5-HT synthesis rates were increased 30-60% in the different brain regions of SERT -/- mice compared to littermate +/+ control mice despite 55-70% reductions in tissue 5-HT concentrations. Brain regions that possessed a greater capacity to increase synthesis and turnover (frontal cortex, striatum) demonstrated lesser reductions in tissue 5-HT. Female SERT -/- mice had greater increases (79%) in brain 5-HT synthesis than male -/- mice did (25%), a finding associated with higher brain tryptophan concentrations in females. Despite increased 5-HT synthesis, there was no change in either TPH2 or TPH1 mRNA levels or in maximal in vitro TPH activity in the brainstem of SERT -/- mice. Catecholamine homeostasis as reflected in brain tissue concentrations and in synthesis and turnover of dopamine and norepinephrine was unchanged in SERT -/- mice. Taken together, the results demonstrate a markedly altered homeostatic situation in SERT -/- mice that lack 5-HT reuptake, resulting in markedly depleted tissue stores that are inadequately compensated for by increased 5-HT synthesis, with brain region and gender specificity observed.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Dinâmica não Linear
Proteínas da Membrana Plasmática de Transporte de Serotonina/deficiência
Serotonina/metabolismo
[Mh] Termos MeSH secundário: Animais
Aorta/metabolismo
Northern Blotting/métodos
Encéfalo/anatomia & histologia
Encéfalo/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão/métodos
Dopamina/metabolismo
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Ácido Hidroxi-Indolacético/metabolismo
Rim/metabolismo
Levodopa/metabolismo
Fígado/metabolismo
Pulmão/metabolismo
Masculino
Metildopa/análogos & derivados
Metildopa/farmacologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Modelos Biológicos
Miocárdio/metabolismo
Noretandrolona/metabolismo
Pâncreas/metabolismo
RNA Mensageiro/metabolismo
Proteínas da Membrana Plasmática de Transporte de Serotonina/fisiologia
Fatores Sexuais
Baço/metabolismo
Fatores de Tempo
Triptofano Hidroxilase/genética
Triptofano Hidroxilase/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Serotonin Plasma Membrane Transport Proteins); 333DO1RDJY (Serotonin); 46627O600J (Levodopa); 54-16-0 (Hydroxyindoleacetic Acid); 56LH93261Y (Methyldopa); 69938-07-4 (alpha-monofluoromethyldopa); EC 1.14.16.4 (Tph1 protein, mouse); EC 1.14.16.4 (Tph2 protein, mouse); EC 1.14.16.4 (Tryptophan Hydroxylase); P7W01638W6 (Norethandrolone); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:0603
[Cu] Atualização por classe:150813
[Lr] Data última revisão:
150813
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050927
[St] Status:MEDLINE


  9 / 170 MEDLINE  
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[PMID]:15955747
[Au] Autor:Kuncová J; Svíglerová J; Tonar Z; Slavíková J
[Ad] Endereço:Department of Physiology, Faculty of Medicine, Charles University, Lidická 1, 301 66 Plzen, Czech Republic. jitka.kuncova@lfp.cuni.cz
[Ti] Título:Heterogenous changes in neuropeptide Y, norepinephrine and epinephrine concentrations in the hearts of diabetic rats.
[So] Source:Auton Neurosci;121(1-2):7-15, 2005 Aug 31.
[Is] ISSN:1566-0702
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The changes in concentrations of neuropeptide Y (NPY), norepinephrine and epinephrine were investigated in the rat hearts 1, 2, 4, 6, 9 and 12 months after administration of streptozotocin (STZ; 65 mg/kg i.v.). About 30% of diabetic animals displayed symptoms of partial spontaneous recovery, i.e. decreasing blood glucose levels and increasing insulin concentrations in the plasma and pancreas. NPY concentrations in the atria of diabetic rats did not differ from those in age-matched control rats 1, 2, 4, 6 months in the right atria and even 9 months after STZ in the left atria. However, uncompensated diabetes led to a significant decrease in NPY levels 9 and 12 months after STZ administration in the right and left atria, respectively. In the ventricles, NPY concentrations were significantly decreased 6 months after the onset of diabetes. Interestingly, partial spontaneous recovery of diabetes was associated with increased NPY levels in the atria. Myocardial norepinephrine concentrations increased 1 month after STZ and then declined reaching approximately 60% of the respective control values 12 months after the onset of the disease. Partial spontaneous recovery of diabetes had no effect on norepinephrine concentrations. Myocardial epinephrine concentrations did not differ from those found in controls till month 9 of the disease and they became significantly lower at month 12. Partial recovery of diabetes resulted in epinephrine concentrations not differing from the control values at month 12 of diabetes. Regarding to preferential localization of norepinephrine in the sympathetic postganglionic fibers and that of NPY also in intrinsic ganglion neurons, intrinsic neuronal circuits seem to be less susceptible to STZ-induced damage than extrinsic nerves and they might be able to recover after amelioration of diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/metabolismo
Epinefrina/metabolismo
Átrios do Coração/metabolismo
Neuropeptídeo Y/metabolismo
Noretandrolona/metabolismo
[Mh] Termos MeSH secundário: Fatores Etários
Análise de Variância
Animais
Glicemia/metabolismo
Diabetes Mellitus Experimental/induzido quimicamente
Modelos Animais de Doenças
Feminino
Teste de Tolerância a Glucose/métodos
Átrios do Coração/efeitos dos fármacos
Imuno-Histoquímica/métodos
Insulina/sangue
Pâncreas/metabolismo
Radioimunoensaio/métodos
Ratos
Ratos Wistar
Estreptozocina
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 0 (Neuropeptide Y); 5W494URQ81 (Streptozocin); P7W01638W6 (Norethandrolone); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:0512
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050616
[St] Status:MEDLINE


  10 / 170 MEDLINE  
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[PMID]:11288196
[Au] Autor:McKinney AR; Ridley DD; Suann CJ
[Ad] Endereço:Australian Racing Forensic Laboratory, P.O. Box 528, Kensington, New South Wales 1465, Australia.
[Ti] Título:The metabolism of norethandrolone in the horse: characterization of 16-, 20- and 21-oxygenated metabolites by gas chromatography/mass spectrometry.
[So] Source:J Mass Spectrom;36(2):145-50, 2001 Feb.
[Is] ISSN:1076-5174
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:After oral administration to a thoroughbred gelding, the anabolic steroid norethandrolone was converted into a complex mixture of oxygenated metabolites. These metabolites were extracted from the urine, deconjugated by methanolysis and converted to their O-methyloxime trimethylsilyl derivatives. Gas chromatographic/mass spectrometric analysis indicated the major metabolites to be 19-norpregnane-3,16,17-triols, 19-norpregnane-3,17,20-triols and 3,17-dihydroxy-19-norpregnan-21-oic acids. Some minor metabolites were also detected.
[Mh] Termos MeSH primário: Cavalos/metabolismo
Noretandrolona/metabolismo
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa
Espectrometria de Massas
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
P7W01638W6 (Norethandrolone)
[Em] Mês de entrada:0106
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010405
[St] Status:MEDLINE



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