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Pesquisa : D04.210.500.745 [Categoria DeCS]
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[PMID]:28747178
[Au] Autor:Durnas B; Piktel E; Watek M; Wollny T; Gózdz S; Smok-Kalwat J; Niemirowicz K; Savage PB; Bucki R
[Ad] Endereço:Department of Microbiology and Immunology, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Kielce, Poland.
[Ti] Título:Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo.
[So] Source:BMC Microbiol;17(1):167, 2017 Jul 26.
[Is] ISSN:1471-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cationic antibacterial peptides (CAPs) and synthetic molecules mimicking the amphiphilic structure of CAPs, such as ceragenins, are promising compounds for the development of new antimicrobials. RESULTS: We tested the in vitro activity of ceragenins CSA-13 and CSA-131 against several anaerobic bacteria including Bacteroides spp. and Clostridium difficile. We compared results to the activity of cathelicidin LL-37, metronidazole and nanosystems developed by attachment of CSA-13 and CSA-131 to magnetic nanoparticles (MNPs). The antibacterial effect was tested using killing assay and modified CLSI broth microdilution assay. Ceragenins CSA-13 and CSA-131 displayed stronger bactericidal activity than LL-37 or metronidazole against all of the tested bacterial strains. Additionally CSA-131 revealed an enhanced ability to prevent the formation of Bacteroides fragilis and Propionibacterium acnes biofilms. CONCLUSIONS: These data confirmed that ceragenins display antimicrobial activity against a broad range of microorganisms including anaerobic bacteria and deserve further investigations as compounds serving to develop new treatment against anaerobic and mixed infections.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Peptídeos Catiônicos Antimicrobianos/farmacologia
Bactérias Anaeróbias/efeitos dos fármacos
Bactérias Anaeróbias/crescimento & desenvolvimento
Nanopartículas de Magnetita/química
Pregnanos/farmacologia
Esteroides/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Peptídeos Catiônicos Antimicrobianos/química
Pregnanos/química
Esteroides/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antimicrobial Cationic Peptides); 0 (Magnetite Nanoparticles); 0 (Pregnanes); 0 (Steroids); 0 (ceragenin CSA-13); 143108-26-3 (CAP18 lipopolysaccharide-binding protein)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1186/s12866-017-1075-6


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[PMID]:28456553
[Au] Autor:Cheng W; Liu Z; Yu Y; van Ofwegen L; Proksch P; Yu S; Lin W
[Ad] Endereço:State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China.
[Ti] Título:An unusual spinaceamine-bearing pregnane from a soft coral Scleronephthya sp. inhibits the migration of tumor cells.
[So] Source:Bioorg Med Chem Lett;27(12):2736-2741, 2017 06 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An unprecedented spinaceamine-bearing pregnane namely scleronine (1) was isolated from a Chinese soft coral Scleronephthya sp. Its structure was determined on the basis of 1D and 2D NMR spectroscopic analyses in association with the HRESIMS data, while the absolute configurations were deduced by the single-crystal X-ray diffraction analysis. In addition, a dehydrogenated analogue (3) was synthesized through six steps with pregna-1,20-dien-3-one (2) as a precursor. The significantly inhibitory effects of 1 and 3 against the migration of tumor cells A549 and B16 accompanying the down-regulation of key genes (TGFß, TNFα, IL-1ß, and IL-6) were observed. These findings suggested that both 1 and 3 are potential for therapeutic usage aiming at cancer metastasis inhibition.
[Mh] Termos MeSH primário: Antozoários/química
Compostos Heterocíclicos com 2 Anéis/farmacologia
Pregnanos/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Compostos Heterocíclicos com 2 Anéis/química
Compostos Heterocíclicos com 2 Anéis/isolamento & purificação
Seres Humanos
Estrutura Molecular
Pregnanos/química
Pregnanos/isolamento & purificação
Teoria Quântica
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Heterocyclic Compounds, 2-Ring); 0 (Pregnanes); 0 (scleronine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:28605593
[Au] Autor:Kendrick S; Muranyi A; Gokhale V; Hurley LH; Rimsza LM
[Ad] Endereço:Department of Pathology, University of Arizona , 1501 North Campbell Avenue, Tucson, Arizona 85724, United States.
[Ti] Título:Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth.
[So] Source:J Med Chem;60(15):6587-6597, 2017 Aug 10.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Secondary DNA structures are uniquely poised as therapeutic targets due to their molecular switch function in turning gene expression on or off and scaffold-like properties for protein and small molecule interaction. Strategies to alter gene transcription through these structures thus far involve targeting single DNA conformations. Here we investigate the feasibility of simultaneously targeting different secondary DNA structures to modulate two key oncogenes, cellular-myelocytomatosis (MYC) and B-cell lymphoma gene-2 (BCL2), in diffuse large B-cell lymphoma (DLBCL). Cotreatment with previously identified ellipticine and pregnanol derivatives that recognize the MYC G-quadruplex and BCL2 i-motif promoter DNA structures lowered mRNA levels and subsequently enhanced sensitivity to a standard chemotherapy drug, cyclophosphamide, in DLBCL cell lines. In vivo repression of MYC and BCL2 in combination with cyclophosphamide also significantly slowed tumor growth in DLBCL xenograft mice. Our findings demonstrate concurrent targeting of different DNA secondary structures offers an effective, precise, medicine-based approach to directly impede transcription and overcome aberrant pathways in aggressive malignancies.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Quadruplex G
Linfoma Difuso de Grandes Células B/tratamento farmacológico
Regiões Promotoras Genéticas
Proteínas Proto-Oncogênicas c-bcl-2/genética
Proteínas Proto-Oncogênicas c-myc/genética
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Benzoxazinas/uso terapêutico
Caspase 3/metabolismo
Linhagem Celular
Ciclofosfamida/uso terapêutico
Sistemas de Liberação de Medicamentos
Elipticinas/uso terapêutico
Técnicas de Silenciamento de Genes
Seres Humanos
Linfoma Difuso de Grandes Células B/patologia
Camundongos
Pregnanos/uso terapêutico
RNA Mensageiro/metabolismo
Carga Tumoral
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (9-(dimethylaminoethoxy)ellipticine); 0 (Antineoplastic Agents); 0 (BCL2 protein, human); 0 (Benzoxazines); 0 (Ellipticines); 0 (IMC-76); 0 (MYC protein, human); 0 (Pregnanes); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Proto-Oncogene Proteins c-myc); 0 (RNA, Messenger); 8N3DW7272P (Cyclophosphamide); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.7b00298


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[PMID]:28561586
[Au] Autor:Seeka C; Prabpai S; Kongsaeree P; Tewtrakul S; Lhinhatrakool T; Sutthivaiyakit S
[Ad] Endereço:Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University , Hua Mark, Bangkapi, Bangkok 10240, Thailand.
[Ti] Título:Anti-inflammatory 12,20-Epoxypregnane and 11,12-seco-Pregnane Glycosides from the Stems of Hoya kerrii.
[So] Source:J Nat Prod;80(6):1714-1724, 2017 Jun 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Five 12,20-epoxypregnane glycosides (1-3, 5, and 6) and two 11,12-seco-pregnane glycosides (4 and 7) with spirodilactone motifs, as well as spirodilactone cleavage products 8 and 9, were isolated from the stems of Hoya kerrii. The relative configurations of the three related skeletons were supported by ROESY experiments and X-ray crystallographic analyses. The isolates were evaluated for their anti-inflammatory activity based on the inhibition of NO production in RAW264.7 cells, and some showed IC values ranging from 12.6 to 96.5 µM. The most potent compound, 9a, was also examined for its anti-inflammatory mechanism against mRNA expression and was found to down-regulate mRNA expression of iNOS and COX-2 in a dose-dependent manner.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Apocynaceae/química
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Pregnanos/isolamento & purificação
Pregnanos/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Cristalografia por Raios X
Ciclo-Oxigenase 2/efeitos dos fármacos
Ciclo-Oxigenase 2/metabolismo
Relação Dose-Resposta a Droga
Glicosídeos/química
Concentração Inibidora 50
Lipopolissacarídeos/farmacologia
Macrófagos/metabolismo
Camundongos
Conformação Molecular
Estrutura Molecular
Óxido Nítrico/biossíntese
Óxido Nítrico Sintase Tipo II/efeitos dos fármacos
Ressonância Magnética Nuclear Biomolecular
Caules de Planta/química
Pregnanos/química
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Glycosides); 0 (Lipopolysaccharides); 0 (Pregnanes); 0 (pregnane glycoside); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00730


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[PMID]:28446029
[Au] Autor:Deng AJ; Zhang D; Li Q; Zhang ZH; Li ZH; Qin HL
[Ad] Endereço:a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
[Ti] Título:Sugar-free pregnane-type steroids from the roots of Cynanchum stauntonii.
[So] Source:J Asian Nat Prod Res;19(6):557-563, 2017 Jun.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new sugar-free 14,15-secopregnane-type steroids, 14-O-methyl-3-epi-hirundigenin (1) and 2-deoxyamplexicogenin A (2), along with two known sugar-free pregnane-type steroids, were isolated from the 95% ethanol extract of the roots of Cynanchum stauntonii. The structures of the new compounds were characterized on the basis of extensive spectroscopic analyses, mainly 1D and 2D NMR methods, albeit the MS experiments did not display the molecular ion peaks. Compound 2 was the aglycones of stauntosides J and K, etc., previously isolated from C. stauntonii. The isolation and identification of the new compounds graced the structural diversity of pregnane-type steroids from C. stauntonii.
[Mh] Termos MeSH primário: Cynanchum/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Raízes de Plantas/química
Pregnanos/isolamento & purificação
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Pregnanos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (14-O-methyl-3-epi-hirundigenin); 0 (2-deoxyamplexicogenin A); 0 (Drugs, Chinese Herbal); 0 (Pregnanes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2017.1319822


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[PMID]:28437621
[Au] Autor:Qian X; Li B; Li P; Wang D; Dai W; Zhang M
[Ad] Endereço:Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.
[Ti] Título:C steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H O -induced damage in PC12 cells.
[So] Source:Phytochemistry;140:1-15, 2017 Aug.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Twenty-three undescribed previously C steroidal glycosides, named saccatols D-K and cynsaccatols I-W, together with six known analogs were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Apocynaceae). Their structures were elucidated by a variety of spectroscopic techniques, as well as HRESIMS and GC method. All isolated compounds were tested their neuroprotective effects on the model of H O -induced damage to PC12 cells. Except saccatols D-F, J, cynsaccatol V and wilfoside A, other twenty-three isolates produced significantly activities against H O -induced cell damage (P < 0.001). Furthermore, cynsaccatols I, N, O and S can obvious inhibition of damaged PC12 cell apoptosis at their dosages of 1 µM by Annexin V-FITC/PI double staining assay with flow cytometry.
[Mh] Termos MeSH primário: Cynanchum/química
Glicosídeos/farmacologia
Fármacos Neuroprotetores/farmacologia
Pregnanos/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose
Glicosídeos/química
Peróxido de Hidrogênio/toxicidade
Estrutura Molecular
Células PC12
Raízes de Plantas/química
Pregnanos/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Neuroprotective Agents); 0 (Pregnanes); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


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[PMID]:28420184
[Au] Autor:Yao HL; Liu Y; Liu XH; Gao H; Liu K; Shao YL; Fang XY; Wang W
[Ad] Endereço:School of Pharmacy, Qingdao University, Qingdao 266021, Shandong, China. xyhuili@126.com.
[Ti] Título:Metajapogenins A-C, Pregnane Steroids from Shells of Metaplexis japonica.
[So] Source:Molecules;22(4), 2017 Apr 17.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the shells of (Thunb.) Makino, belonging to the family of Apocynaceae, afforded three new pregnane steroids, metajapogenins A-C, along with three known compounds. The structures of the new compounds were elucidated as 12ß,14ß,17ß-trihydroxypregna-3,5-dien-7,20-dione, 12ß,14ß,17ß,20ß-tetrahydroxypregna-3,5-dien-7-one; 3ß,12ß,14ß,17ß-tetrahydroxypregn-5-ene-7,20-dione on the basis of extensive spectroscopic evidence derived from 1D; 2D-NMR experiments and mass spectrometry. The known compounds included pergularin; 12- -acetylpergularin; and pergularin-3- -ß-d-oleandropyranose; which were identified for the first time in the shells of . .
[Mh] Termos MeSH primário: Apocynaceae/química
Pregnanos/química
[Mh] Termos MeSH secundário: Animais
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Pregnanes)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


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[PMID]:28300701
[Au] Autor:Gao F; Yao YC; Cai SB; Zhao TR; Yang XY; Fan J; Li XN; Cao JX; Cheng GG
[Ad] Endereço:Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 6505000, People's Republic of China.
[Ti] Título:Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum.
[So] Source:Fitoterapia;118:107-111, 2017 Apr.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation on the leaves of Epigynum auritum led to the isolation of three novel C pregnane glycosides, epigynosides, E-G (1-3), together with two known pregnane glycosides, epigynosides A (4) and C (5). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D and 2D NMR) analysis, as well as comparison with the reported data. The immunological activities of the new compounds was evaluated against concanavalin A (Con A)-stimulated proliferation of mice splenocyte in vitro. Compounds 1-3 displayed significant immunosuppressive activities, close to the efficacy of the positive control (dexamethasone) at the concentration of 50µM.
[Mh] Termos MeSH primário: Apocynaceae/química
Glicosídeos/química
Imunossupressores/química
Pregnanos/química
Baço/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Células Cultivadas
Glicosídeos/isolamento & purificação
Seres Humanos
Imunossupressores/isolamento & purificação
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Estrutura Molecular
Folhas de Planta/química
Pregnanos/isolamento & purificação
Baço/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Immunosuppressive Agents); 0 (Pregnanes); 0 (pregnane glycoside)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


  9 / 2289 MEDLINE  
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[PMID]:28294615
[Au] Autor:Wang LY; Qin JJ; Chen ZH; Zhou Y; Tang W; Zuo JP; Zhao WM
[Ad] Endereço:Department of Natural Product Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, People's Republic of China.
[Ti] Título:Absolute Configuration of Periplosides C and F and Isolation of Minor Spiro-orthoester Group-Containing Pregnane-type Steroidal Glycosides from Periploca sepium and Their T-Lymphocyte Proliferation Inhibitory Activities.
[So] Source:J Nat Prod;80(4):1102-1109, 2017 Apr 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Further phytochemical investigation of the root bark of Periploca sepium afforded nine new spiro-orthoester group-containing pregnane-type glycosides termed periplosides O-V and 3-O-formyl-periploside A. The structures of these glycosides along with the absolute configuration of the unique seven-membered formyl acetal-bridged spiro-orthoester function and the 4,6-dideoxy-3-O-methyl-Δ -2-hexosulosyl moiety were elucidated on the basis of spectroscopic data interpretation and chemical transformation. The absolute configurations of the major compounds periplosides C and F were established by single-crystal X-ray diffraction analysis. The isolated compounds were evaluated for their inhibitory activities against the proliferation of T-lymphocytes. As a result, periploside C, the most abundant glycoside containing a spiro-orthoester moiety found in the plant, exhibited the most favorite selective index value (SI = 82.5). The length and constitution of the saccharide chain in the periplosides were found to influence the inhibitory activity and the SI value.
[Mh] Termos MeSH primário: Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Imunossupressores/isolamento & purificação
Imunossupressores/farmacologia
Periploca/química
Pregnanos/isolamento & purificação
Pregnanos/farmacologia
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Glicosídeos/química
Imunossupressores/química
Estrutura Molecular
Raízes de Plantas/química
Pregnanos/química
Linfócitos T/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Immunosuppressive Agents); 0 (Pregnanes); 0 (periploside C); 0 (periploside F); 0 (pregnane glycoside)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00017


  10 / 2289 MEDLINE  
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[PMID]:28284564
[Au] Autor:Yu JQ; Lin MB; Deng AJ; Hou Q; Bai JY; Li ZH; Ma L; Zhang ZH; Yuan SP; Jiang RT; Qin HL
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, Shandong Province, C
[Ti] Título:14,15-Secopregnane-type C -steriosides from the roots of Cynanchum stauntonii.
[So] Source:Phytochemistry;138:152-162, 2017 Jun.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nine 14,15-secopregnane-type C -steriosides, stauntosides U, V, V -V , W and C -C , as well as two known C -steriosides, were isolated from the roots of Cynanchum stauntonii. Stauntosides U, V and V -V share the same basic structural features of 8α:14α,14:16,15:20,18:20-tetraepoxy-14,15-secopregn-6-ene-3ß,5α,9α-triol, with the numbering system following that of C -pregnanes. The aglycones of stauntosides U, V and V -V are classified into two subcategories, the 5,9-dihydroxy groups and 5α:9α-peroxy bridge, according to the oxidative states of the two hydroxy groups at the C-5 and C-9 positions. The anti-inflammatory activity of the major compounds was assessed in an in vitro inflammatory model of mouse peritoneal macrophages using IC values of the inhibition of nitric oxide (NO) production as an indicator. Stauntosides V and V exhibited target activity with IC values of 9.3 µM and 12.4 µM, respectively, compared with dexamethasone, which was used as a positive control.
[Mh] Termos MeSH primário: Cynanchum/química
Raízes de Plantas/química
Pregnanos/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Macrófagos Peritoneais/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Estrutura Molecular
Óxido Nítrico/metabolismo
Pregnanos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Pregnanes); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE



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