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[PMID]:25841896
[Au] Autor:van der Drift SG; Houweling M; Bouman M; Koets AP; Tielens AG; Nielen M; Jorritsma R
[Ad] Endereço:Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. Electronic address: sgavanderdrift@gmail.com.
[Ti] Título:Effects of a single glucocorticoid injection on propylene glycol-treated cows with clinical ketosis.
[So] Source:Vet J;204(2):144-9, 2015 May.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the metabolic effects of glucocorticoids when administered to propylene glycol-treated cows with clinical ketosis. Clinical ketosis was defined by depressed feed intake and milk production, and a maximal score for acetoacetate in urine. All cows received 250 mL oral propylene glycol twice daily for 3 days and were randomly assigned to a single intramuscular injection with sterile isotonic saline solution (n = 14) or dexamethasone-21-isonicotinate (n = 17). Metabolic blood variables were monitored for 6 days and adipose tissue variables for 3 days. ß-Hydroxybutyrate (BHBA) concentrations in blood decreased in all cows during treatment, but were lower in glucocorticoid-treated cows. Cows treated with glucocorticoids had higher plasma glucose and insulin concentrations, whereas concentrations of non-esterified fatty acids, 3-methylhistidine and growth hormone were unaffected. mRNA expression of hormone-sensitive lipase, BHBA receptor and peroxisome proliferator-activated receptor type γ in adipose tissue was not affected. This shows that lipolytic effects do not appear to be important in ketotic cows when glucocorticoids are combined with PG. Plasma 3-methyl histidine concentrations were similar in both groups, suggesting that glucocorticoids did not increase muscle breakdown and that the greater rise in plasma glucose in glucocorticoid-treated cows may not be due to increased supply of glucogenic amino acids from muscle.
[Mh] Termos MeSH primário: Doenças dos Bovinos/tratamento farmacológico
Isonicotinato de Dexametasona/uso terapêutico
Glucocorticoides/uso terapêutico
Cetose/veterinária
Propilenoglicol/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Bovinos
Isonicotinato de Dexametasona/administração & dosagem
Quimioterapia Combinada
Feminino
Glucocorticoides/administração & dosagem
Insulina/sangue
Cetose/tratamento farmacológico
Metilistidinas/sangue
Propilenoglicol/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Insulin); 0 (Methylhistidines); 368-16-1 (3-methylhistidine); 6DC9Q167V3 (Propylene Glycol); 8LGC0BOA71 (Dexamethasone Isonicotinate)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150406
[St] Status:MEDLINE


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[PMID]:24178798
[Au] Autor:Thordarson DB
[Ti] Título:Highlight article: January-June 2013.
[So] Source:Foot Ankle Int;34(11):1471, 2013 Nov.
[Is] ISSN:1944-7876
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Toxinas Botulínicas Tipo A/uso terapêutico
Isonicotinato de Dexametasona/uso terapêutico
Fasciíte Plantar/terapia
Glucocorticoides/uso terapêutico
Fármacos Neuromusculares/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; EDITORIAL
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Neuromuscular Agents); 8LGC0BOA71 (Dexamethasone Isonicotinate); EC 3.4.24.69 (Botulinum Toxins, Type A)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:140827
[Lr] Data última revisão:
140827
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131102
[St] Status:MEDLINE
[do] DOI:10.1177/1071100713508735


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[PMID]:23386757
[Au] Autor:Elizondo-Rodriguez J; Araujo-Lopez Y; Moreno-Gonzalez JA; Cardenas-Estrada E; Mendoza-Lemus O; Acosta-Olivo C
[Ad] Endereço:Universidad Autonoma de Nuevo Leon, Mexico.
[Ti] Título:A comparison of botulinum toxin a and intralesional steroids for the treatment of plantar fasciitis: a randomized, double-blinded study.
[So] Source:Foot Ankle Int;34(1):8-14, 2013 Jan.
[Is] ISSN:1071-1007
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The objective of this study was to compare intramuscularly applied botulinum toxin A (BTX-A) in the gastroc-soleus complex with intralesional steroids for the treatment of plantar fasciitis. METHODS: The patients were randomly divided into 2 groups according to the treatment received. The patients were evaluated over 6 months. The evaluation scores included the Visual Analog Scale (VAS), Maryland Foot and Ankle, Foot and Ankle Disability Index (FADI), and American Orthopaedic Foot and Ankle Society (AOFAS) score. Moreover, patients were instructed to perform plantar fascia stretching exercises over the course of the study. The final number of patients was 36, of whom 19 received BTX-A (10 men and 9 women) and 17 (6 men and 11 women) received steroids. RESULTS: When compared to patients who received steroids, the patients who received BTX-A exhibited more rapid and sustained improvement over the duration of the study. CONCLUSION: A combination of BTX-A and plantar fascia stretching exercises yielded better results for the treatment of plantar fasciitis than intralesional steroids. LEVEL OF EVIDENCE: Level I, therapeutic studies.
[Mh] Termos MeSH primário: Toxinas Botulínicas Tipo A/uso terapêutico
Isonicotinato de Dexametasona/uso terapêutico
Fasciíte Plantar/terapia
Glucocorticoides/uso terapêutico
Fármacos Neuromusculares/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Avaliação da Deficiência
Método Duplo-Cego
Feminino
Seres Humanos
Injeções Intralesionais
Injeções Intramusculares
Masculino
Meia-Idade
Exercícios de Alongamento Muscular
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Neuromuscular Agents); 8LGC0BOA71 (Dexamethasone Isonicotinate); EC 3.4.24.69 (Botulinum Toxins, Type A)
[Em] Mês de entrada:1303
[Cu] Atualização por classe:140827
[Lr] Data última revisão:
140827
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130207
[St] Status:MEDLINE
[do] DOI:10.1177/1071100712460215


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[PMID]:23194055
[Au] Autor:Kusenda M; Kaske M; Piechotta M; Locher L; Starke A; Huber K; Rehage J
[Ad] Endereço:Clinic for Cattle, University of Veterinary Medicine Hannover, Hannover, Germany.
[Ti] Título:Effects of dexamethasone-21-isonicotinate on peripheral insulin action in dairy cows 5 days after surgical correction of abomasal displacement.
[So] Source:J Vet Intern Med;27(1):200-6, 2013 Jan-Feb.
[Is] ISSN:1939-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dexamethasone frequently is used for treatment of ketosis in dairy cows, but its effects are not fully understood. HYPOTHESIS: Dexamethasone treatment affects whole body insulin sensitivity. ANIMALS: Twelve German Holstein cows, 2-4 weeks postpartum, 5 days after omentopexy to correct left abomasal displacement. METHODS: Randomized, blinded, case-control study. Treatment with dexamethasone-21-isonicotinate (DG; 40 µg/kg IM; n = 6) or saline (control group [CG], 15 mL IM, n = 6) on day 0 (d0). Blood samples were obtained before (d0) and after treatment (d1 and d2), and analyzed for glucose, insulin, and nonesterified fatty acid (NEFA) concentrations. Hepatic triglycerides (TAG) were measured in liver samples taken on d0 and d2. Five consecutive hyperinsulinemic-euglycemic clamps (HEC-I-V; insulin dosages: 0.1, 0.5, 2, 5, 10 mU/kg/min, respectively) were performed on d1 and steady state glucose infusion rate (SSGIR), insulin concentration (SSIC), insulin sensitivity index (ISI = SSGIR/SSIC), and plasma NEFA concentration (SSNEFA) were assessed. RESULTS: Compared with CG-cows, DG-cows on d1 had higher plasma glucose (P = .004) and insulin (P < .001) concentrations, decreased SSGIR (HEC-II, P = .002; HEC-IV, P = .033), ISI (HEC-I, P < .015; HEC-II, P = .004), and insulin-stimulated decrease in SSNEFA (HEC-II, P = .006; HEC-III, P = .01; HEC-IV, P = .003; HEC-V, P = .011). Decrease in hepatic TAG content in DG-cows was higher compared with CG-cows (P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Dexamethasone decreases whole body insulin sensitivity and affects glucose and lipid metabolism in early lactating dairy cows.
[Mh] Termos MeSH primário: Abomaso/cirurgia
Doenças dos Bovinos/cirurgia
Indústria de Laticínios
Isonicotinato de Dexametasona/farmacologia
Insulina/sangue
Gastropatias/veterinária
[Mh] Termos MeSH secundário: Animais
Glicemia
Estudos de Casos e Controles
Bovinos
Relação Dose-Resposta a Droga
Gastropatias/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 8LGC0BOA71 (Dexamethasone Isonicotinate)
[Em] Mês de entrada:1306
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121201
[St] Status:MEDLINE
[do] DOI:10.1111/jvim.12010


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[PMID]:18849577
[Au] Autor:Cannizzo FT; Miniscalco B; Riondato F; Bollo E; Barbarino G; Giorgi P; Mazzini C; Biolatti B
[Ad] Endereço:Dipartimento di Patalogia Animale, University of Turin, via L. Da Vinci 44, 10095 Grugliasco, TO, Italy.
[Ti] Título:Effects of anabolic and therapeutic doses of dexamethasone on thymus morphology and apoptosis in veal calves.
[So] Source:Vet Rec;163(15):448-52, 2008 Oct 11.
[Is] ISSN:0042-4900
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three groups of 10 veal calves were treated, respectively, with 5 mg of dexamethasone-21-isonicotinate administered intramuscularly on days 0 and 7 (group A); 0.4 mg/day of dexamethasone-21-phosphate administered orally for 20 days (group B); or left untreated as controls (group C). Two animals from each group were slaughtered on day 3, 7, 14, 32 and 52. The size and weight of the thymus decreased progressively in both treated groups until day 32. On day 14, in comparison with the controls, there was a mean reduction of 76 per cent in the thymus weight of group A and 35 per cent in group B. On day 32, the reductions were 13 per cent in group A and 50 per cent in group B, but the thymus weight of both groups had recovered completely by day 52. Dexamethasone-induced changes in thymus weight associated with lymphoid depletion and fat replacement, and there were clear correlations between these changes and apoptosis of thymocytes.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Bovinos/anatomia & histologia
Dexametasona/administração & dosagem
Glucocorticoides/administração & dosagem
Timo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Isonicotinato de Dexametasona/administração & dosagem
Citometria de Fluxo/veterinária
Injeções Intramusculares/veterinária
Itália
Distribuição Aleatória
Timo/citologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glucocorticoids); 7S5I7G3JQL (Dexamethasone); 8LGC0BOA71 (Dexamethasone Isonicotinate)
[Em] Mês de entrada:0812
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081014
[St] Status:MEDLINE


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[PMID]:16594601
[Au] Autor:Couëtil LL; Art T; de Moffarts B; Becker M; Mélotte D; Jaspar F; Bureau F; Lekeux P
[Ad] Endereço:Department of Physiology, Faculty of Veterinary Medicine, University of Liège, Belgium. couetill@purdue.edu
[Ti] Título:Effect of beclomethasone dipropionate and dexamethasone isonicotinate on lung function, bronchoalveolar lavage fluid cytology, and transcription factor expression in airways of horses with recurrent airway obstruction.
[So] Source:J Vet Intern Med;20(2):399-406, 2006 Mar-Apr.
[Is] ISSN:0891-6640
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties of GC are thought to be mediated by suppression of inflammatory gene expression via inhibition of transcription factors such as nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1). The purpose of this study was to evaluate the effect of low-dose inhaled beclomethasone dipropionate and injectable dexamethasone 21-isonicotinate on clinical signs, pulmonary function, airway cytology, and activity of NF-kappaB and AP-1 in bronchial cells of RAO-affected horses. Seven horses with RAO were exposed to moldy hay until they developed airway obstruction on 3 separate occasions. In a crossover design, they were then treated with a placebo (injection on day 1), inhaled beclomethasone (500 microg q12h for 10 days), or dexamethasone (0.06 mg/kg, IM on day 1) and monitored for 10 days. Pulmonary function, bronchoalveolar lavage fluid cytology, and NF-kappaB and AP-1 activity in bronchial brushing cells were measured before (day 1) and after treatment (day 10). Treatment with beclomethasone resulted in significantly improved pulmonary function of RAO-affected horses compared with placebo and dexamethasone treatments. However, none of the treatments had an effect on bronchoalveolar lavage fluid cytology or NF-kappaB and AP-1 activity. These findings reveal that, in a model of severe RAO, the benefits of low-dose inhaled beclomethasone on pulmonary function are not accompanied by a decrease in airway inflammatory cells or a suppression of transcription factors NF-kappaB and AP-1 DNA-binding activity.
[Mh] Termos MeSH primário: Beclometasona/farmacologia
Líquido da Lavagem Broncoalveolar/citologia
Isonicotinato de Dexametasona/farmacologia
Doenças dos Cavalos/tratamento farmacológico
Pneumopatias Obstrutivas/veterinária
Pulmão/efeitos dos fármacos
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Beclometasona/uso terapêutico
Estudos Cross-Over
Isonicotinato de Dexametasona/uso terapêutico
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Cavalos
Pulmão/fisiopatologia
Pneumopatias Obstrutivas/tratamento farmacológico
Masculino
Terapia Respiratória
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Transcription Factors); 8LGC0BOA71 (Dexamethasone Isonicotinate); KGZ1SLC28Z (Beclomethasone)
[Em] Mês de entrada:0605
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060406
[St] Status:MEDLINE


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[PMID]:15803762
[Au] Autor:Wittek T; Wittek K; Fürll M
[Ad] Endereço:Medizinische Tierklinik, Universität Leipzig. wittek@vetmed.uni-leipzig.de
[Ti] Título:[Effects of a single dose of dexamethasone-21-isonicotinate on the phagocytosis performance of neutrophilic granulocytes and monocytes in periparturient dairy cows].
[Ti] Título:Auswirkungen einer einmaligen Gabe von Dexamethason-21-isonicotinat auf die Phagozytoseleistung von neutrophilen Granulozyten und Monozyten bei Kühen im Frühpuerperium..
[So] Source:Berl Munch Tierarztl Wochenschr;118(3-4):140-9, 2005 Mar-Apr.
[Is] ISSN:0005-9366
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:The objective of the study was to describe the effects of a short acting glucocorticoid which was administered immediately after parturition in dairy cows on haematological, immunologic and metabolic parameters. The study was performed on 104 cows, 52 cows received an intramuscular injection of 2 mg/100 kg BW dexamethasone within 12 hours after parturition. The numbers and the phagocytic activity of granulocytes and monocytes were measured on day 1 and day 3 post partum in 17 randomly chosen cows from each group. From day 1 to day 3 the percentage of phagocytic granulocytes increased in the dexamethasone group from 73.2 +/- 6.1% to 79.6 +/- 6.6% (P < 0.05); in the control group the percentage remained unchanged (74.7 +/- 6.3% and 76.2 +/- 5.8%). The cellular phagocytic activity of granulocytes did not change significantly between day 1 and 3. In both groups the phagocytic activity of monocytes also remained unchanged. The concentrations of endotoxin, haptoglobin and the anti-lipid-A-IgG-antibody-titer did not show significant differences between the groups. Between both groups differences were not observed in the clinical parameters, milk yield or in the incidence of diseases in the peripartal period. The effects of the glucocorticoid on the metabolic parameters were especially seen in bilirubin and free fatty acid concentration. The present study shows that a single injection of glucocorticoids within 12 hours after parturition did not influence the phagocytic activity of neutrophils and monocytes negatively and did not have an effect on the measured parameters of acute-phase-response. Therefore, it seems possible to benefit from the positive effects of glucocorticoids on metabolism in this critical early postpartal period in high yielding cows.
[Mh] Termos MeSH primário: Bovinos/imunologia
Isonicotinato de Dexametasona/farmacologia
Glucocorticoides/farmacologia
Granulócitos/imunologia
Monócitos/imunologia
Fagocitose/efeitos dos fármacos
[Mh] Termos MeSH secundário: Reação de Fase Aguda
Animais
Doenças dos Bovinos/sangue
Doenças dos Bovinos/imunologia
Metabolismo Energético/efeitos dos fármacos
Feminino
Granulócitos/efeitos dos fármacos
Lactação/efeitos dos fármacos
Lactação/imunologia
Contagem de Leucócitos/veterinária
Monócitos/efeitos dos fármacos
Período Pós-Parto
Gravidez
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 8LGC0BOA71 (Dexamethasone Isonicotinate)
[Em] Mês de entrada:0506
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050405
[St] Status:MEDLINE


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[PMID]:15551926
[Au] Autor:Jorritsma R; Thanasak J; Houweling M; Noordhuizen JP; Müller KE
[Ad] Endereço:Department of Farm Animal Health, Faculty of Veterinary Medicine, Yalelaan 7, Utrecht, The Netherlands.
[Ti] Título:Effects of a single dose of dexamethasone-21-isonicotinate on the metabolism of heifers in early lactation.
[So] Source:Vet Rec;155(17):521-3, 2004 Oct 23.
[Is] ISSN:0042-4900
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eight Swedish crossbred heifers, about two-and-a-half years old, were given a single intramuscular dose of dexamethasone-21-isonicotinate between nine and 15 days after they had calved and eight similar heifers were left untreated. The treatment had no significant effects on the lipolytic activity of the heifers' fat tissues, and no effect on the concentrations of non-esterified fatty acids and beta-hydroxybutyrate in blood or the triacylglycerol content of the liver. However, there were significant increases in plasma glucose concentrations two days after the injection and in plasma insulin concentrations two and four days after the injection.
[Mh] Termos MeSH primário: Tecido Adiposo/efeitos dos fármacos
Bovinos/metabolismo
Isonicotinato de Dexametasona/farmacologia
Metabolismo Energético/efeitos dos fármacos
Glucocorticoides/farmacologia
Lactação/metabolismo
Lipólise/efeitos dos fármacos
[Mh] Termos MeSH secundário: Ácido 3-Hidroxibutírico/sangue
Tecido Adiposo/metabolismo
Animais
Aspartato Aminotransferases/sangue
Glicemia/efeitos dos fármacos
Glicemia/metabolismo
Ácidos Graxos não Esterificados/sangue
Feminino
Insulina/sangue
Insulina/metabolismo
Fígado/efeitos dos fármacos
gama-Glutamiltransferase/sangue
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Fatty Acids, Nonesterified); 0 (Glucocorticoids); 0 (Insulin); 8LGC0BOA71 (Dexamethasone Isonicotinate); EC 2.3.2.2 (gamma-Glutamyltransferase); EC 2.6.1.1 (Aspartate Aminotransferases); TZP1275679 (3-Hydroxybutyric Acid)
[Em] Mês de entrada:0412
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:041124
[St] Status:MEDLINE


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[PMID]:15099507
[Au] Autor:Thanasak J; Jorritsma R; Hoek A; Noordhuizen JP; Rutten VP; Müller KE
[Ad] Endereço:Department of Farm Animal Health, Faculty of Veterinary Medicine, Yalelaan 7, Utrecht, The Netherlands. j.thanasak@vet.uu.nl
[Ti] Título:The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum.
[So] Source:Vet Res;35(1):103-12, 2004 Jan-Feb.
[Is] ISSN:0928-4249
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dexamethasone is a potent therapeutic for treatment of the fatty liver syndrome or primary ketosis in post partum dairy cows. Reservations exist, however, among practitioners with respect to the risk of immunosuppression induced by corticosteroids. The aim of this study was to investigate the effect of a single injection of dexamethasone-21-isonicotinate on distinct immune functions of postpartum dairy cows because only scarce information is available on the effects of corticosteroid preparations when administered at a dosage and frequency for treatment of the fatty liver syndrome or primary ketosis. Sixteen Swedish red-pied dairy cows, between days 9 and 15 post partum, were allotted to either a control group (n = 8) or a treatment group (n = 8). The cows in the treatment group received a single intramuscular injection of a dexamethasone-21-isonicotinate suspension at a dosage of 0.02 mg/kg i.m. at the start of the experiment. White blood cell counts and selected lymphocyte functions (lymphocyte proliferation, expression of lymphocyte markers and the b2 and a4 chain of adhesion molecules belonging to the integrin family) and some parameters of the energy metabolism (glucose, insulin) were determined before the administration of corticosteroids (day 0) and subsequently at days 2, 4, 7 and 9 of the experiment. Changes in glucose and insulin were within the target range for treatment of the fatty liver syndrome or primary ketosis. Significant (P < 0.05) increases in the number of circulating white blood cells were observed in treated cows on the second day following treatment which was exclusively caused by an increase in the number of circulating neutrophils. Lymphocyte blastogenesis in response to ConA and the percentages of lymphocytes positive for CD2, CD4, CD8, CD49d and CD18 as well as the intensity of CD49d expression did not differ between the treatment and control groups. There was, however, a significant reduction (P < 0.01) in the intensity of CD18 expression on lymphocytes in the treated animals on the fourth day after treatment. In conclusion, a single administration of dexamethasone-21-isonicotinate in a dosage of 0.02 mg/kg i.m. at two weeks post partum in healthy cows had a significant but highly transient effect on CD18 expression on lymphocytes and the number of peripheral blood neutrophils, but did not affect lymphocyte blastogenesis or lymphocyte subpopulation patterns in peripheral blood.
[Mh] Termos MeSH primário: Doenças dos Bovinos/imunologia
Isonicotinato de Dexametasona/uso terapêutico
Metabolismo Energético/efeitos dos fármacos
Fígado Gorduroso/veterinária
Glucocorticoides/uso terapêutico
Cetose/veterinária
Linfócitos/fisiologia
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Antígenos CD18/análise
Bovinos
Doenças dos Bovinos/tratamento farmacológico
Isonicotinato de Dexametasona/administração & dosagem
Isonicotinato de Dexametasona/efeitos adversos
Fígado Gorduroso/tratamento farmacológico
Fígado Gorduroso/imunologia
Feminino
Citometria de Fluxo/veterinária
Glucocorticoides/administração & dosagem
Glucocorticoides/efeitos adversos
Imunofenotipagem/veterinária
Injeções Intramusculares/veterinária
Integrina alfa4/análise
Cetose/tratamento farmacológico
Cetose/imunologia
Ativação Linfocitária/efeitos dos fármacos
Contagem de Linfócitos/veterinária
Linfócitos/efeitos dos fármacos
Período Pós-Parto
Distribuição Aleatória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (CD18 Antigens); 0 (Glucocorticoids); 143198-26-9 (Integrin alpha4); 8LGC0BOA71 (Dexamethasone Isonicotinate)
[Em] Mês de entrada:0409
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040422
[St] Status:MEDLINE


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Fotocópia
[PMID]:12464066
[Au] Autor:Pappalardo E; Abramo F; Noli C
[Ad] Endereço:Studio Dermatologico Veterinario, Milan, Italy.
[Ti] Título:Pemphigus foliaceus in a goat.
[So] Source:Vet Dermatol;13(6):331-6, 2002 Dec.
[Is] ISSN:0959-4493
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 7-year-old-female goat was referred with a 3-month history of chronic dermatitis, which partially responded to combined corticosteroid and antibiotic therapy. At dermatological examination diffuse alopecia, pustules and crusts were observed on the head, neck, dorsum and perianal area. Dermatophyte culture and skin scrapings were negative. Trichoscopic examination revealed a concurrent infestation with Damalinia caprae, which was successfully treated with ivermectin. Cytological examination of pus from intact pustules revealed nondegenerate neutrophils, absence of bacteria and numerous nucleated, irregularly shaped keratinocytes. Histopathological examination of lesional skin revealed intracorneal pustules containing neutrophils and acantholytic cells, and a mixed cell superficial perivascular dermatitis. Immunohistochemical stains of lesional skin showed intercellular IgG deposits in the spinous layer. Remission of the dermatitis was obtained with injectable dexamethasone-21-isonicotinate, every two months for one year. This is the first report to describe the cytological appearance of impression smears from intact pustules of pemphigus foliaceus in a goat and to document the presence of IgG deposits in lesional skin by means of immunohistochemistry.
[Mh] Termos MeSH primário: Doenças das Cabras/diagnóstico
Infestações por Piolhos/veterinária
Pênfigo/veterinária
[Mh] Termos MeSH secundário: Alopecia/etiologia
Alopecia/veterinária
Animais
Isonicotinato de Dexametasona/administração & dosagem
Isonicotinato de Dexametasona/uso terapêutico
Diagnóstico Diferencial
Feminino
Glucocorticoides/administração & dosagem
Glucocorticoides/uso terapêutico
Doenças das Cabras/tratamento farmacológico
Doenças das Cabras/patologia
Cabras
Imuno-Histoquímica/veterinária
Injeções/veterinária
Ivermectina/uso terapêutico
Infestações por Piolhos/complicações
Infestações por Piolhos/diagnóstico
Pênfigo/complicações
Pênfigo/diagnóstico
Ftirápteros
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 70288-86-7 (Ivermectin); 8LGC0BOA71 (Dexamethasone Isonicotinate)
[Em] Mês de entrada:0302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:021205
[St] Status:MEDLINE



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