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  1 / 2001 MEDLINE  
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[PMID]:28368525
[Au] Autor:Santoro N; Crawford SL; El Khoudary SR; Allshouse AA; Burnett-Bowie SA; Finkelstein J; Derby C; Matthews K; Kravitz HM; Harlow SD; Greendale GA; Gold EB; Kazlauskaite R; McConnell D; Neal-Perry G; Pavlovic J; Randolph J; Weiss G; Chen HY; Lasley B
[Ad] Endereço:Department of Ob/Gyn, University of Colorado School of Medicine, Aurora, Colorado 80045.
[Ti] Título:Menstrual Cycle Hormone Changes in Women Traversing Menopause: Study of Women's Health Across the Nation.
[So] Source:J Clin Endocrinol Metab;102(7):2218-2229, 2017 Jul 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Menstrual cycle hormone patterns in women approaching menopause are inadequately studied. Objective: To describe day-to-day menstrual cycle hormones in women as they approach menopause from the Study of Women's Health Across the Nation Daily Hormone Study (DHS). Design: DHS enrollees collected daily urine for one entire menstrual cycle or up to 50 days, whichever came first, annually, up to the final menstrual period (FMP) or for up to 10 years. Setting: Seven sites across the United States. Participants: A total of 511 premenopausal or early perimenopausal women at enrollment, within 10 years before menopause. Intervention: Time-to-FMP measurement. Main Outcome Measures: Evidence of luteal activity (ELA), determined using objective algorithms. Menstrual cycle/segment length; whole cycle, and segment integrated urinary luteinizing hormone, follicle-stimulating hormone, estrone conjugates, and pregnanediol glucuronide (Pdg) for each year, organized around the FMP. Results: Mean menstrual cycle length was remarkably preserved at 26 to 27 days in ELA cycles; non-ELA cycles had greater variability. The percentage of cycles that were ELA remained high until 5 years before the FMP (87.9%); only 22.8% of cycles within 1 year of the FMP were ELA. Whole cycle hormones remained relatively stable up to 3 years before the FMP, when gonadotropins began to increase. Pdg excretion declined slowly with progress to the FMP, but Pdg patterns of ELA cycles remained distinguishable from non-ELA. Conclusions: Menstrual cycle hormone patterns in perimenopausal women resemble those of midreproductive-aged women until 5 years before menopause, and presumably ovulatory cycles retain a potentially fertile pattern up to the end of reproductive life.
[Mh] Termos MeSH primário: Hormônios/metabolismo
Ciclo Menstrual/metabolismo
Perimenopausa/metabolismo
[Mh] Termos MeSH secundário: Afroamericanos
Grupo com Ancestrais do Continente Asiático
Índice de Massa Corporal
Corpo Lúteo/fisiologia
Estradiol/metabolismo
Estrona/metabolismo
Grupo com Ancestrais do Continente Europeu
Feminino
Hormônio Foliculoestimulante/metabolismo
Seres Humanos
Hormônio Luteinizante/metabolismo
Ciclo Menstrual/etnologia
Meia-Idade
Perimenopausa/etnologia
Pregnanodiol/análogos & derivados
Pregnanodiol/metabolismo
Pré-Menopausa/etnologia
Pré-Menopausa/metabolismo
Saúde da Mulher
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Hormones); 1852-49-9 (pregnanediol-3 alpha-glucuronide); 2DI9HA706A (Estrone); 4TI98Z838E (Estradiol); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-4017


  2 / 2001 MEDLINE  
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[PMID]:27859398
[Au] Autor:Kinoshita K; Sano Y; Takai A; Shimizu M; Kobayashi T; Ouchi A; Kuze N; Inoue-Murayama M; Idani G; Okamoto M; Ozaki Y
[Ad] Endereço:Primate Research Institute, Kyoto University, Inuyama, Japan.
[Ti] Título:Urinary sex steroid hormone and placental leucine aminopeptidase concentration differences between live births and stillbirth of Bornean orangutans (Pongo pygmaeus).
[So] Source:J Med Primatol;46(1):3-8, 2017 Feb.
[Is] ISSN:1600-0684
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Under the environment of pregnancy, the placenta assumes an important steroidogenic role in the maintenance of pregnancy. METHODS: Urinary placental leucine aminopeptidase (PLAP), estrone-3-glucuronide (E G), and pregnanediol-3-glucuronide (PdG) concentrations were compared among five pregnancies (four live births and one stillbirth) in four orangutans. RESULTS: The gestation period of the stillbirth (223 days) was shorter than that of the live births (239-254 days). In females who gave a live birth, average PLAP and E G concentrations increased until the delivery. Conversely, in the female who gave a stillbirth, PLAP concentration failed to increase, and E G concentration was significantly low in late pregnancy period. Regarding PdG concentrations, there was no significant difference among all pregnancies. CONCLUSIONS: This is the first study reporting a change in urinary PLAP, E G, and PdG concentrations during orangutan stillbirth and live birth pregnancies. The findings will assist in developing pregnancy screening tests.
[Mh] Termos MeSH primário: Cistinil Aminopeptidase/análise
Hormônios Esteroides Gonadais/urina
Nascimento Vivo/veterinária
Placenta/enzimologia
Pongo pygmaeus/fisiologia
Natimorto/veterinária
[Mh] Termos MeSH secundário: Animais
Estrona/análogos & derivados
Estrona/urina
Feminino
Gravidez
Pregnanodiol/análogos & derivados
Pregnanodiol/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 1852-49-9 (pregnanediol-3 alpha-glucuronide); 2479-90-5 (estrone-3-glucuronide); 2DI9HA706A (Estrone); EC 3.4.11.3 (Cystinyl Aminopeptidase); EC 3.4.11.3 (leucyl-cystinyl aminopeptidase); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1111/jmp.12249


  3 / 2001 MEDLINE  
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[PMID]:27743688
[Au] Autor:Muren; Kusuda S; Doi O; Naito H; Hashikawa H
[Ad] Endereço:Laboratory of Animal Reproduction, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
[Ti] Título:Puberty, ovarian cycle, pregnancy, and postpartum ovulation in captive Sichuan golden monkeys (Rhinopithecus roxellana) based on changes in urinary and fecal gonadal steroid metabolites.
[So] Source:Theriogenology;87:179-186, 2017 Jan 01.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to evaluate the reproductive status and clarify the reproductive physiology of captive Sichuan golden monkeys. The concentrations of urinary estradiol-3-glucuronide (E G) and pregnanediol-glucuronide (PdG) or fecal estradiol-17ß (E ) and PdG in two females, and fecal testosterone concentrations in a male, were measured continuously using enzyme immunoassays. On the basis of these hormone profiles, the follicular phase, luteal phase, and ovarian cycle were calculated to be 14.7 ± 4.8, 10.4 ± 2.8, and 25.1 ± 3.3 days, respectively. The first ovulation (puberty) in a female monkey was observed at 5.1 years old, and the first pregnancy was diagnosed at 6.4 years old. For the first 2 months of pregnancy (204 days), fecal E and PdG maintained constant high values and then increased until parturition. These profiles were similar to urinary E G and PdG changes. During the last trimester of a twin pregnancy, fecal PdG was up to approximately three times higher compared with a single pregnancy. Therefore, fecal PdG levels in late pregnancy may be effective for the detection of a twin pregnancy. The first postpartum ovulation occurred 66 (fetal death and artificial rearing), 143 (fetal death), and 189 (natural suckling) days after parturition. The anovulation period of the natural suckling case was longer than the others. Conception and postpartum ovulation were detected between September and January. Fecal testosterone levels of the male were correlated with the fecal E level of the nonpregnancy period in exhibited together female. Our results reported that urinary (E G and PdG) and fecal (E and PdG) hormone measurement is effective for monitoring the reproductive status, thereby expanding knowledge of the reproductive endocrinology of this endangered species.
[Mh] Termos MeSH primário: Estradiol/análogos & derivados
Haplorrinos/fisiologia
Ovulação/fisiologia
Prenhez
Pregnanodiol/análogos & derivados
Maturidade Sexual/fisiologia
[Mh] Termos MeSH secundário: Animais
Estradiol/química
Estradiol/metabolismo
Estradiol/urina
Fezes/química
Feminino
Masculino
Gravidez
Prenhez/fisiologia
Pregnanodiol/química
Pregnanodiol/metabolismo
Pregnanodiol/urina
Testosterona/química
Testosterona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
15270-30-1 (estradiol-3-glucuronide); 1852-49-9 (pregnanediol-3 alpha-glucuronide); 3XMK78S47O (Testosterone); 4TI98Z838E (Estradiol); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161017
[St] Status:MEDLINE


  4 / 2001 MEDLINE  
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[PMID]:27636357
[Au] Autor:Binnie JE; Cooke DG; Blackwell LF
[Ad] Endereço:a Institute of Molecular Biosciences , Massey University , Palmerston North , New Zealand.
[Ti] Título:Establishment of a reference ELISA for measurement of universal thresholds of pregnanediol glucuronide excretion rates using urine samples diluted to a constant volume per unit time.
[So] Source:J Immunoassay Immunochem;38(2):202-220, 2017.
[Is] ISSN:1532-4230
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An enzyme-linked immunosorbent assay (ELISA) for measurement of pregnanediol-3α-glucuronide (PdG) excretion rates in urine samples diluted to 150 mL/h before analysis is described. The sensitivity of the 9 optimized standard curves was 0.093 ± 0.070 µmol PdG/24 hr, with the multiple combined standard curves having a mean mid-point (EC ) of 6.88 µmol PdG/24 hr. The PdG threshold excretion rate of 7.0 µmol/24 hr, which is used as a marker for the end of fertility, was situated in the most accurate region of the standard curve. The specificity of the ELISA was determined using normal variate transformation to compare seven menstrual cycle profiles obtained with the ELISA method with the profiles obtained previously using a validated radioimmunoassay (RIA) method. The cycle profiles all agreed within experimental error, and a high degree of correlation using Deming regression was obtained. The correlation equation was Y = 1.57X-0.11 µmol PdG/24 hr (n = 200; r = 0.932). The PdG excretion rates determined by the ELISA were 50% higher than given by RIA, but the normal ranges were similar to those given by the original reference gas liquid chromatographic method. The ELISA assay was therefore suitable as a reference method for measurement of thresholds of PdG excretion rates.
[Mh] Termos MeSH primário: Ensaio de Imunoadsorção Enzimática/normas
Pregnanodiol/análogos & derivados
[Mh] Termos MeSH secundário: Biomarcadores/urina
Seres Humanos
Pregnanodiol/urina
Radioimunoensaio
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 1852-49-9 (pregnanediol-3 alpha-glucuronide); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.1080/15321819.2016.1236730


  5 / 2001 MEDLINE  
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[PMID]:27666565
[Au] Autor:Johnson L; Sammel MD; Schanne A; Lechtenberg L; Prewitt M; Gracia C
[Ad] Endereço:Division of Reproductive Endocrinology and Infertility, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Reproductive Endocrinology Associates of Charlotte, Charlotte, North Carolina. Electronic address: laurenjohnsonmd@gmail.com.
[Ti] Título:Female cancer survivors exposed to alkylating-agent chemotherapy have unique reproductive hormone profiles.
[So] Source:Fertil Steril;106(7):1793-1799.e2, 2016 Dec.
[Is] ISSN:1556-5653
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate reproductive hormone patterns in women exposed to alkylating-agent chemotherapy. DESIGN: Prospective cohort. SETTING: University hospital. PATIENT(S): Normally menstruating mid-reproductive-age women (20-35 years old) who had previously been exposed to alkylating-agent chemotherapy for cancer treatment were compared with two healthy control populations: similarly-aged women and late-reproductive-age women (43-50 years old). INTERVENTION(S): Subjects collected daily urine samples for one cycle. MAIN OUTCOME MEASURE(S): Integrated urinary pregnanediol glucuronide (PDG) and estrone conjugate (E1c) and urinary excretion of gonadotropins (FSH and LH). RESULT(S): Thirty-eight women (13 survivors, 11 same-age control subjects, 14 late-reproductive-age control subjects) provided 1,082 urine samples. Cycle length, luteal phase length, and evidence of luteal activity were similar among the groups. As expected, ovarian reserve was impaired in cancer survivors compared with same-age control subjects but similar between survivors and late-reproductive-age control subjects. In contrast, survivors had total and peak PDG levels that were similar to same-age control subjects and higher than those observed in late-reproductive-age control subjects. Survivors had higher E1c levels than both same-age and late-reproductive-age control subjects. There was no difference in urinary gonadotropins among the groups. CONCLUSION(S): Women exposed to alkylating agents have a unique reproductive hormone milieu that is not solely explained by age or ovarian reserve. The urinary hormone profile observed in survivors appears more similar to same-age control subjects than to late-reproductive-age women with similar ovarian reserve, which may suggest that age plays a more important role than ovarian reserve in the follicular dynamics of survivors.
[Mh] Termos MeSH primário: Antineoplásicos Alquilantes/efeitos adversos
Estrona/urina
Hormônio Foliculoestimulante Humano/urina
Glucuronídeos/urina
Hormônio Luteinizante/urina
Ovulação/efeitos dos fármacos
Pregnanodiol/urina
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Biomarcadores/urina
Estudos de Casos e Controles
Estrona/análogos & derivados
Feminino
Hospitais Universitários
Seres Humanos
Meia-Idade
Reserva Ovariana/efeitos dos fármacos
Pregnanodiol/análogos & derivados
Estudos Prospectivos
Urinálise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Alkylating); 0 (Biomarkers); 0 (Follicle Stimulating Hormone, Human); 0 (Glucuronides); 2DI9HA706A (Estrone); 9002-67-9 (Luteinizing Hormone); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170607
[Lr] Data última revisão:
170607
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


  6 / 2001 MEDLINE  
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[PMID]:27356506
[Au] Autor:Douglas PH; Hohmann G; Murtagh R; Thiessen-Bock R; Deschner T
[Ad] Endereço:Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany. heidi_douglas@eva.mpg.de.
[Ti] Título:Mixed messages: wild female bonobos show high variability in the timing of ovulation in relation to sexual swelling patterns.
[So] Source:BMC Evol Biol;16(1):140, 2016 Jun 30.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The evolution of primate sexual swellings and their influence on mating strategies have captivated the interest of biologists for over a century. Across the primate order, variability in the timing of ovulation with respect to females' sexual swelling patterns differs greatly. Since sexual swellings typically function as signals of female fecundity, the temporal relation between ovulation and sexual swellings can impact the ability of males to pinpoint ovulation and thereby affect male mating strategies. Here, we used endocrine parameters to detect ovulation and examined the temporal relation between the maximum swelling phase (MSP) and ovulation in wild female bonobos (Pan paniscus). Data were collected at the Luikotale field site, Democratic Republic of Congo, spanning 36 months. Observational data from 13 females were used to characterise female swelling cycles (N = 70). Furthermore, we measured urinary oestrone and pregnanediol using liquid chromatography-tandem mass spectrometry, and used pregnanediol to determine the timing of ovulation in 34 cycles (N = 9 females). RESULTS: We found that the duration of females' MSP was highly variable, ranging from 1 to 31 days. Timing of ovulation varied considerably in relation to the onset of the MSP, resulting in a very low day-specific probability of ovulation and fecundity across female cycles. Ovulation occurred during the MSP in only 52.9 % of the analysed swelling cycles, and females showed regular sexual swelling patterns in N = 8 swelling cycles where ovulation did not occur. These findings reveal that sexual swellings of bonobos are less reliable indicators of ovulation compared to other species of primates. CONCLUSIONS: Female bonobos show unusual variability in the duration of the MSP and in the timing of ovulation relative to the sexual swelling signal. These data are important for understanding the evolution of sexual signals, how they influence male and female mating strategies, and how decoupling visual signals of fecundity from the periovulatory period may affect intersexual conflict. By prolonging the period during which males would need to mate guard females to ascertain paternity, the temporal variability of this signal may constrain mate-guarding efforts by male bonobos.
[Mh] Termos MeSH primário: Ovulação
Pan paniscus/fisiologia
Comportamento Sexual Animal
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida
Congo
Estrona/urina
Feminino
Fertilidade
Masculino
Pan paniscus/urina
Pregnanodiol/urina
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
2DI9HA706A (Estrone); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.1186/s12862-016-0691-3


  7 / 2001 MEDLINE  
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[PMID]:27251885
[Au] Autor:Pavlovic JM; Allshouse AA; Santoro NF; Crawford SL; Thurston RC; Neal-Perry GS; Lipton RB; Derby CA
[Ad] Endereço:From the Departments of Neurology (J.M.P., R.B.L., C.A.D.) and Epidemiology and Population Health (R.B.L., C.A.D.), Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY; Department of Obstetrics and Gynecology (A.A.A., N.F.S.), University of Colorado Denver, Aurora; Division of P
[Ti] Título:Sex hormones in women with and without migraine: Evidence of migraine-specific hormone profiles.
[So] Source:Neurology;87(1):49-56, 2016 Jul 05.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare daily sex hormone levels and rates of change between women with history of migraine and controls. METHODS: History of migraine, daily headache diaries, and daily hormone data were collected in ovulatory cycles of pre- and early perimenopausal women in the Study of Women's Health Across the Nation. Peak hormone levels, average daily levels, and within-woman day-to-day rates of decline over the 5 days following each hormone peak were calculated in ovulatory cycles for conjugated urinary estrogens (E1c), pregnanediol-3-glucuronide, luteinizing hormone, and follicle-stimulating hormone. Comparisons were made between migraineurs and controls using 2-sample t tests on the log scale with results reported as geometric means. RESULTS: The sample included 114 women with history of migraine and 223 controls. Analyses of within-woman rates of decline showed that E1c decline over the 2 days following the luteal peak was greater in migraineurs for both absolute rate of decline (33.8 [95% confidence interval 28.0-40.8] pg/mgCr vs 23.1 [95% confidence interval 20.1-26.6] pg/mgCr, p = 0.002) and percent change (40% vs 30%, p < 0.001). There was no significant difference between migraineurs and controls in absolute peak or daily E1c, pregnanediol-3-glucuronide, luteinizing hormone, and follicle-stimulating hormone levels. Secondary analyses demonstrated that, among migraineurs, the rate of E1c decline did not differ according to whether a headache occurred during the cycle studied. CONCLUSIONS: Migraineurs are characterized by faster late luteal phase E1c decline compared to controls. The timing and rate of estrogen withdrawal before menses may be a marker of neuroendocrine vulnerability in women with migraine.
[Mh] Termos MeSH primário: Estrogênios/urina
Hormônio Foliculoestimulante/urina
Hormônio Luteinizante/urina
Transtornos de Enxaqueca/urina
Pregnanodiol/análogos & derivados
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Estudos Longitudinais
Menopausa/urina
Ciclo Menstrual/urina
Meia-Idade
Periodicidade
Pregnanodiol/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Estrogens); 1852-49-9 (pregnanediol-3 alpha-glucuronide); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000002798


  8 / 2001 MEDLINE  
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[PMID]:26875514
[Au] Autor:Habumuremyi S; Stephens C; Fawcett KA; Deschner T; Robbins MM
[Ad] Endereço:Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany; Dian Fossey Gorilla Fund International, 800 Cherokee Ave SE, Atlanta, GA 30315-1440, USA; Institut d'Enseignement Supérieur de Ruhengeri (INES-Ruhengeri), Musanze, North Province, Rwanda. Electronic address: sosthene_habumuremy@ev
[Ti] Título:Endocrine assessment of ovarian cycle activity in wild female mountain gorillas (Gorilla beringei beringei).
[So] Source:Physiol Behav;157:185-95, 2016 Apr 01.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Variability of fertility (i.e. number of births per female per year) has been reported in females of many primate species but only a few studies have explored the associated physiological and behavioral patterns. To investigate the proximate mechanisms of variability in fertility of wild female mountain gorillas (Gorilla beringei beringei), we quantified the occurrence of ovulation, matings, and successful pregnancies among females. We examined the profiles of immunoreactive pregnanediol-3-glucuronide (iPdG) for sixteen females (seven nulliparous and nine parous females, including one geriatric female; average sampling period for fecal sample collection and behavioral observations per female=175 days; SD=94 days, range=66-358 days) monitored by the staff of the Dian Fossey Gorilla Fund's Karisoke Research Center in Parc National des Volcans, Rwanda. We quantified ovarian cycles from iPdG profiles using an algorithm that we developed by adjusting the method of Kassam et al. (1996) to the characteristics of ovarian cycle profiles based on fecal hormone measurements. The mean length of ovarian cycles was 29±4 days (median: 28 days, N=13 cycles), similar to ovarian cycle lengths of other great apes and humans. As expected, we found that female mountain gorillas exhibit longer follicular phases (mean±SD: 21±3 days, N=13 cycles) than luteal phases (mean±SD: 8±3 days, N=13 cycles). We also found that the frequency of ovarian cycles was greater in parous females (i.e. 20 ovarian cycles across 44 periods of 28 days; 45.5%) than in nulliparous females (i.e. two ovarian cycles across 34 periods of 28 days; 6%). However, the frequency of days on which matings were observed did not differ significantly between parous and nulliparous females, nor between pregnant and non-pregnant females. Five pregnancies were detected with iPdG levels, but only three resulted in live births, indicating miscarriages of the other two. In sum, this study provides information on the underlying endocrine patterns of variation in fertility depending on parity, mating behavior, and pregnancy success in a critically endangered great ape.
[Mh] Termos MeSH primário: Gorilla gorilla/fisiologia
Ciclo Menstrual/metabolismo
Gravidez/fisiologia
Pregnanodiol/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Feminino
Pregnanodiol/metabolismo
Comportamento Sexual Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
1852-49-9 (pregnanediol-3 alpha-glucuronide); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160216
[St] Status:MEDLINE


  9 / 2001 MEDLINE  
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[PMID]:26677961
[Au] Autor:Blackwell LF; Vigil P; Alliende ME; Brown S; Festin M; Cooke DG
[Ad] Endereço:Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand l.f.blackwell@massey.ac.nz.
[Ti] Título:Monitoring of ovarian activity by measurement of urinary excretion rates using the Ovarian Monitor, Part IV: the relationship of the pregnanediol glucuronide threshold to basal body temperature and cervical mucus as markers for the beginning of the post-ovulatory infertile period.
[So] Source:Hum Reprod;31(2):445-53, 2016 Feb.
[Is] ISSN:1460-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:STUDY QUESTION: Do the basal body temperature (BBT) shift and the cervical mucus markers for the beginning of the post-ovulatory infertile phase (POIP) of a menstrual cycle agree with the corresponding urinary pregnanediol glucuronide (PdG) threshold value? SUMMARY ANSWER: Perfect agreement between the cervical mucus markers and BBT shift and the hormonal definition of the start of post-ovulatory infertility occurred for only 7-17% of the cycles. WHAT IS KNOWN ALREADY: The PdG threshold of 7.0 µmol/24 h is an objective and accurate marker for the beginning of the POIP. The rise in serum progesterone also produces the BBT shift and changes in cervical mucus which determine the mucus peak. Serum progesterone and urinary PdG are closely correlated when variations in urine volume are taken into account. STUDY DESIGN, SIZE, DURATION: Individual menstrual cycle profiles of urinary PdG excretion rates for 91 fertile cycles from normally cycling women were analysed to identify the day of the beginning of the POIP. These days were compared with those determined by the day of the BBT shift +2 days, the day of the mucus peak +4 days and the later of these two indicators. The study lasted 3 years. PARTICIPANTS/MATERIALS, SETTING, METHODS: A total of 62 women with normal menstrual cycles were recruited from three centres: Palmerston North, New Zealand; Sydney, Australia and Santiago, Chile. The cycles were displayed individually in a proprietary database program which recorded the PdG excretion rates, the BBT shift day and the cervical mucus peak day. A group of 15 women from a separate Chilean study had PdG urinary data measured as well as their day of ovulation determined by ultrasound. MAIN RESULTS AND THE ROLE OF CHANCE: The BBT and cervical mucus markers differed significantly in their identification of the beginning of the POIP when compared with the PdG excretion rate of 7.0 µmol/24 h. The observation that the BBT shift day and the mucus peak day could be identified even though the PdG excretion rates were still at baseline levels in some cycles could lead to an unexpected pregnancy for women using these natural family planning (NFP) indicators. LIMITATIONS, REASONS FOR CAUTION: The study consisted only of fertile cycles from women with regular cycles of 20-40 days duration. All the women were intending to avoid a pregnancy during the study, thus the limits of the fertile window were not tested. WIDER IMPLICATIONS OF THE FINDINGS: The NFP signals occurring earlier than the PdG threshold day could lead to an unexpected pregnancy. The signals occurring on the same day or later than the PdG threshold would not lead to unexpected pregnancies, but would require extra abstinence that could lead to non-compliance with the NFP method. A possible improvement in reliability of NFP methods is suggested. STUDY FUNDING/COMPETING INTERESTS: This study (project #90905) was funded by the NDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP). D.G.C. currently works for a diagnostic development company, Science Haven Ltd. The other authors have nothing to declare.
[Mh] Termos MeSH primário: Temperatura Corporal
Muco do Colo Uterino
Glucuronídeos/urina
Pregnanodiol/urina
[Mh] Termos MeSH secundário: Adulto
Biomarcadores
Feminino
Seres Humanos
Ciclo Menstrual/metabolismo
Ciclo Menstrual/urina
Detecção da Ovulação
Pregnanodiol/análogos & derivados
Progesterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Glucuronides); 4G7DS2Q64Y (Progesterone); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151219
[St] Status:MEDLINE
[do] DOI:10.1093/humrep/dev303


  10 / 2001 MEDLINE  
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[PMID]:26454526
[Au] Autor:Mithileshwari C; Srivastava T; Kumar V; Kumar A; Umapathy G
[Ad] Endereço:Laboratory for the Conservation of Endangered Species (LaCONES), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India.
[Ti] Título:Non-invasive assessment of fecal progestagens and pregnancy detection in Himalayan musk deer (Moschus chrysogaster).
[So] Source:Theriogenology;85(2):216-23, 2016 Jan 15.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Himalayan musk deer (Moschus chrysogaster), an endangered species, is facing threat of extinction globally due to severe hunting for its musk, and efforts are under way in India to breed them in captivity. However, no information is available on the reproductive cycles of the species. In this study, we aimed to standardize an enzyme immunoassay (EIA) procedure for monitoring pregnancy using fecal samples. We collected fecal samples for 12 months from five captive females maintained at the Musk Deer Research Centre, Bageshwar, Uttarakhand, India. Three of these females were observed mating and gave birth, whereas two were seen mating but did not give birth. The gestation periods for the three females were 183, 185, and 199 days, respectively. High-pressure liquid chromatography revealed the presence of immunoreactive pregnanediol-3-glucuronide (PdG), progesterone, and 5α-pregnan-3α-ol-20-one (5-alpha-pregnane) metabolites in the fecal samples. We used EIAs against progesterone, PdG, and 5-alpha-pregnane to monitor pregnancy. We found PdG EIA to be a highly accurate and sensitive assay compared with the other two assays in detecting pregnancy. We conclude that PdG EIA can be used to diagnose and monitor pregnancy in Himalayan musk deer using fecal steroid analysis, at an early stage of 3 months after mating. This study would help in conservation breeding of musk deer in captivity and in monitoring the reproductive status of the species in the wild.
[Mh] Termos MeSH primário: Fezes/química
Testes de Gravidez/veterinária
Progestinas/análise
Ruminantes
[Mh] Termos MeSH secundário: Animais
Conservação dos Recursos Naturais
Espécies em Perigo de Extinção
Feminino
Técnicas Imunoenzimáticas/veterinária
Índia
Gravidez
Testes de Gravidez/métodos
Pregnanodiol/análogos & derivados
Pregnanodiol/análise
Pregnanos/análise
Progesterona/análise
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pregnanes); 0 (Progestins); 1852-49-9 (pregnanediol-3 alpha-glucuronide); 4G7DS2Q64Y (Progesterone); JR3JD1Y22C (Pregnanediol)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151216
[Lr] Data última revisão:
151216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151012
[St] Status:MEDLINE



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