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[PMID]:23216953
[Au] Autor:Brown TC
[Ad] Endereço:(Formely) Royal Childrens Hospital, Melbourne, Vic, Australia.
[Ti] Título:Thiopentone and its challengers.
[So] Source:Paediatr Anaesth;23(10):957-8, 2013 Oct.
[Is] ISSN:1460-9592
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Anestesia Intravenosa
Anestésicos Intravenosos
Tiopental
[Mh] Termos MeSH secundário: Mistura de Alfaxalona Alfadolona/química
Mistura de Alfaxalona Alfadolona/história
Mistura de Alfaxalona Alfadolona/farmacologia
Anestesia Intravenosa/história
Anestesiologia
Anestésicos Intravenosos/química
Anestésicos Intravenosos/história
Anestésicos Intravenosos/farmacologia
Barbitúricos/história
Criança
História do Século XX
Seres Humanos
Ketamina/história
Ketamina/farmacologia
Pediatria
Propofol/história
Propofol/farmacologia
Oxibato de Sódio/química
Oxibato de Sódio/história
Oxibato de Sódio/farmacologia
Relação Estrutura-Atividade
Tiopental/química
Tiopental/história
Tiopental/farmacologia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (Barbiturates); 690G0D6V8H (Ketamine); 7G33012534 (Sodium Oxybate); 8067-82-1 (Alfaxalone Alfadolone Mixture); JI8Z5M7NA3 (Thiopental); YI7VU623SF (Propofol)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121211
[St] Status:MEDLINE
[do] DOI:10.1111/pan.12083


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[PMID]:19520338
[Au] Autor:Blaha M; Budoff MJ; Shaw LJ; Khosa F; Rumberger JA; Berman D; Callister T; Raggi P; Blumenthal RS; Nasir K
[Ad] Endereço:Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD 21287, USA.
[Ti] Título:Absence of coronary artery calcification and all-cause mortality.
[So] Source:JACC Cardiovasc Imaging;2(6):692-700, 2009 Jun.
[Is] ISSN:1876-7591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We sought to quantify the mortality rates associated with absent and low positive (CAC 1 to 10) coronary artery calcium (CAC). BACKGROUND: There is increasing interest in the absence of CAC as a "negative" cardiovascular risk factor. However, published event rates for individuals with no CAC vary, likely owing to differences in baseline risk, follow-up period, and outcome ascertainment. The prognostic significance of low CAC (CAC 1 to 10) is not well described. METHODS: Annualized all-cause mortality rates were assessed in 44,052 consecutive asymptomatic patients referred for CAC testing. Mean follow-up of the cohort was 5.6 +/- 2.6 years (range 1 to 13 years). RESULTS: A total of 19,898 patients (45%) had no CAC on screening electron beam tomography, whereas 5,388 (12%) had low levels of CAC (CAC 1 to 10), and 18,766 (43%) had CAC >10. There were 104 deaths in those with no CAC (0.52%), 58 deaths in those with CAC 1 to 10 (1.06%), and 739 deaths in those with CAC >10 (3.96%). Annualized all-cause mortality rates for CAC = 0, CAC 1 to 10, and CAC >10 were 0.87, 1.92, and 7.48 deaths/1,000 person-years, respectively. The hazard ratio (HR) for all-cause mortality among CAC 1 to 10 versus CAC = 0 after adjustment for traditional risk factors was 1.99 (95% confidence interval [CI]: 1.44 to 2.75). Smoking (HR: 3.97, 95% CI: 2.75 to 5.41) and diabetes mellitus (HR: 3.36, 95% CI: 2.09 to 5.41) were associated with few events observed in CAC = 0 group. CONCLUSIONS: In appropriately selected asymptomatic patients, the absence of CAC predicts excellent survival with 10-year event rates of approximately 1%. A finding of 0 CAC might be used as a rationale to emphasize lifestyle therapies rather than pharmacotherapy and to forgo repeated imaging studies. Individuals with low CAC score (CAC 1 to 10) are at increased risk above individuals with a 0 score and could be considered a distinct risk group by physicians and investigators.
[Mh] Termos MeSH primário: Calcinose/mortalidade
Doença da Artéria Coronariana/mortalidade
[Mh] Termos MeSH secundário: Idoso
Mistura de Alfaxalona Alfadolona
Calcinose/diagnóstico por imagem
Causas de Morte
Doença da Artéria Coronariana/diagnóstico por imagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Prognóstico
Radiografia
Fatores de Risco
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
8067-82-1 (Alfaxalone Alfadolone Mixture)
[Em] Mês de entrada:0909
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090613
[St] Status:MEDLINE
[do] DOI:10.1016/j.jcmg.2009.03.009


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[PMID]:19093743
[Au] Autor:Ruane-O'Hora T; Hall WJ; Markos F
[Ad] Endereço:Department of Physiology, University College Cork, Cork, Ireland. t.ruane-ohora@ucc.ie
[Ti] Título:The effect of ketamine and saffan on the beta-endorphin and ACTH response to hemorrhage in the minipig.
[So] Source:Physiol Res;58(6):799-805, 2009.
[Is] ISSN:0862-8408
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:The endocrine response is an important component of the physiological response to blood loss. There is some variability in reported levels of certain hormones during hemorrhage such as the stress hormone adrenocorticotrophic hormone (ACTH). Therefore, the effect of two anesthetic agents, ketamine and saffan, on ACTH and beta-endorphin levels during hemorrhage was assessed in 12 minipigs. The animals were divided into two groups, group I saffan and group II ketamine (n=6). Pigs were subjected to a continuous fixed volume hemorrhage under one of the above anesthetics while spontaneously breathing. Blood pressure and heart rate responses were recorded together with beta-endorphin and ACTH levels both before and at 10, 20, 30, 40 min after the onset of bleeding. ACTH levels were higher in the ketamine-anesthetized pigs and rose significantly faster with falling blood pressure than ACTH measured in pigs under saffan anesthesia. In contrast, the hemorrhage induced beta-endorphin increase was not significantly different between the two anesthetic groups. These results indicate that choice of anesthetic agent is important when investigating the hormone response to hemorrhage and may account for the variable hormone levels in the published literature to date.
[Mh] Termos MeSH primário: Hormônio Adrenocorticotrópico/sangue
Mistura de Alfaxalona Alfadolona/farmacologia
Anestésicos/farmacologia
Hemorragia/sangue
Ketamina/farmacologia
beta-Endorfina/sangue
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Pressão Sanguínea/efeitos dos fármacos
Modelos Animais de Doenças
Frequência Cardíaca/efeitos dos fármacos
Suínos
Porco Miniatura
Fatores de Tempo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics); 0 (Biomarkers); 60617-12-1 (beta-Endorphin); 690G0D6V8H (Ketamine); 8067-82-1 (Alfaxalone Alfadolone Mixture); 9002-60-2 (Adrenocorticotropic Hormone)
[Em] Mês de entrada:1002
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081220
[St] Status:MEDLINE


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[PMID]:15027622
[Au] Autor:Schwenke DO; Cragg PA
[Ad] Endereço:Department of Physiology, University of Otago, Dunedin School of Medicine, PO Box 56, Dunedin, New Zealand.
[Ti] Título:Comparison of the depressive effects of four anesthetic regimens on ventilatory and cardiovascular variables in the guinea pig.
[So] Source:Comp Med;54(1):77-85, 2004 Feb.
[Is] ISSN:1532-0820
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Guinea pigs are one of the most difficult rodents to anesthetize safely, and as a consequence, there is a paucity of reports regarding the effects of anesthesia on their cardiorespiratory variables. We used long-term indwelling cannulas for studying the guinea pig in the conscious state, and subsequently investigated the effects of four types of injectable anesthetic regimens on cardiorespiratory variables. METHODS: Using barometric plethysmography (conscious: long-term cannulated, n = 11; no cannulation, n = 28) or trachea-out plethysmography (anesthetized: n = 7 for each of the four groups), we recorded ventilatory, cardiovascular, metabolic, and arterial gas variables during air breathing and in response to 10 min of hypoxia (8% O2) and 10 min of hypercapnia (8% CO2). The four anesthetic regimens tested were: Saffan (infused at 9.75 mg/kg of body weight/h, i.v.); ketamine/xylazine (14.6/3.7 mg/kg/h, i.v.); pentobarbitone (8.3 mg/kg/h, i.v.) plus Innovar Vet (0.15 mg/kg every 1 to 1.5 h, s.c.); or pentobarbitone alone (22 mg/kg/h, i.v.). RESULTS: The least depressive anesthetic with regard to ventilation (VE) was ketamine/xylazine. Air breathing was depressed by only 17% (cf approx 50 to 60% for all other regimes), and the VE responses to hypoxia and hypercapnia were attenuated the least. All anesthetics equally depressed mean arterial blood pressure (from 70 mmHg to 56 mmHg) and ketamine/xylazine was the only anesthetic to reduce heart rate (from 260 beats/min to 198 beats/min). CONCLUSION: Although all anesthetics induce cardiorespiratory depression to some extent, the use of ketamine/ xylazine is recommended for future use in respiratory studies of the guinea pig where anesthesia cannot be avoided.
[Mh] Termos MeSH primário: Anestesia/efeitos adversos
Anestesia/métodos
Anestésicos/efeitos adversos
Hemodinâmica/efeitos dos fármacos
Pletismografia/veterinária
Respiração/efeitos dos fármacos
[Mh] Termos MeSH secundário: Mistura de Alfaxalona Alfadolona/efeitos adversos
Animais
Pressão Sanguínea/efeitos dos fármacos
Droperidol/efeitos adversos
Quimioterapia Combinada
Feminino
Fentanila/efeitos adversos
Cobaias
Frequência Cardíaca/efeitos dos fármacos
Ketamina/efeitos adversos
Pentobarbital/efeitos adversos
Xilazina/efeitos adversos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics); 2KFG9TP5V8 (Xylazine); 690G0D6V8H (Ketamine); 8067-59-2 (Innovar); 8067-82-1 (Alfaxalone Alfadolone Mixture); I4744080IR (Pentobarbital); O9U0F09D5X (Droperidol); UF599785JZ (Fentanyl)
[Em] Mês de entrada:0409
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040319
[St] Status:MEDLINE


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[PMID]:14512213
[Au] Autor:Mathew SJ; Shungu DC; Mao X; Smith EL; Perera GM; Kegeles LS; Perera T; Lisanby SH; Rosenblum LA; Gorman JM; Coplan JD
[Ad] Endereço:Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.
[Ti] Título:A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors.
[So] Source:Biol Psychiatry;54(7):727-35, 2003 Oct 01.
[Is] ISSN:0006-3223
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Long-term behavioral, immunologic, and neurochemical alterations have been found in primates exposed to adverse early rearing. METHODS: Bonnet macaque (Macaca radiata) mother-infant dyads were exposed to uncertain requirements for food procurement (variable foraging demand, VFD) for a few months. Ten years later, these offspring and age- and gender-matched control subjects were studied using proton magnetic resonance spectroscopic imaging (MRSI). RESULTS: In anterior cingulate, VFD-reared subjects displayed significantly decreased N-acetylaspartate (NAA) resonance and significantly increased glutamate-glutamine-gamma-aminobutyric acid (Glx) resonance relative to the stable neurometabolite creatine (Cr). Across all subjects, NAA/Cr and Glx/Cr ratios in the anterior cingulate were negatively correlated (r = -.638, p =.014). In the medial temporal lobe, the ratio of choline-containing compounds to Cr was significantly increased in VFD subjects. CONCLUSIONS: These findings indicate that adverse early rearing in primates has an enduring impact on adult MRSI measures considered reflective of neuronal integrity and metabolism, membrane structure and glial function, and cerebral glutamate content, and that these alterations occur in the same brain regions implicated in trauma-related psychiatric disorders.
[Mh] Termos MeSH primário: Ácido Aspártico/análogos & derivados
Química Encefálica
Espectroscopia de Ressonância Magnética
Estresse Psicológico/fisiopatologia
[Mh] Termos MeSH secundário: Mistura de Alfaxalona Alfadolona/administração & dosagem
Animais
Ácido Aspártico/análise
Mapeamento Encefálico
Estudos de Casos e Controles
Colina/análise
Creatina/análise
Antagonistas GABAérgicos/administração & dosagem
Ácido Glutâmico/análise
Glutamina/análise
Giro do Cíngulo/anatomia & histologia
Giro do Cíngulo/metabolismo
Macaca radiata/psicologia
Masculino
Estresse Psicológico/psicologia
Lobo Temporal/anatomia & histologia
Lobo Temporal/metabolismo
Ácido gama-Aminobutírico/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (GABA Antagonists); 0RH81L854J (Glutamine); 30KYC7MIAI (Aspartic Acid); 3KX376GY7L (Glutamic Acid); 56-12-2 (gamma-Aminobutyric Acid); 8067-82-1 (Alfaxalone Alfadolone Mixture); 997-55-7 (N-acetylaspartate); MU72812GK0 (Creatine); N91BDP6H0X (Choline)
[Em] Mês de entrada:0310
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030927
[St] Status:MEDLINE


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[PMID]:12839874
[Au] Autor:Boothman LJ; Allers KA; Rasmussen K; Sharp T
[Ad] Endereço:University Department of Pharmacology, Mansfield Road, Oxford OX1 3QT.
[Ti] Título:Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat.
[So] Source:Br J Pharmacol;139(5):998-1004, 2003 Jul.
[Is] ISSN:0007-1188
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. Systemic administration of phenethylamine-derived, 5-hydroxytryptamine(2) (5-HT(2)) receptor agonists inhibits the firing of midbrain 5-HT neurones, but the 5-HT receptors involved are poorly defined, and the contribution of peripheral mechanisms is uncertain. This study addresses these issues using extracellular recordings of 5-HT neurones in the dorsal raphe nucleus of anaesthetised rats. 2. The 5-HT(2) receptor agonists DOI ((+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride) and DOB ((+/-)-2,5-dimethoxy-4-bromoamphetamine hydrobromide), caused a dose-related (10-100 micro g kg(-1) i.v.) inhibition of 5-HT neuronal activity, with the highest dose reducing firing rates by >80%. 3. Pretreatment with the 5-HT(2) receptor antagonist ritanserin (1 mg kg(-1) i.v.) completely blocked the action of DOI. The 5-HT(2A) receptor antagonist MDL 100,907 (0.2 mg kg(-1) i.v.) blocked the action of both DOI and DOB. In comparison, the 5-HT(2B/C) receptor antagonist SB 206553 (0.5 mg kg(-1) i.v.) caused a small, but statistically significant, shift to the right in the dose response to DOI and DOB. 4. Pretreatment with the peripherally acting 5-HT(2) receptor antagonist BW 501C67 (0.1 mg kg(-1) i.v.) had no effect on the DOI-induced inhibition of 5-HT cell firing, but completely blocked the DOI-induced rise in mean arterial blood pressure. 5. These data indicate that the inhibition of 5-HT cell firing induced by systemic administration of DOI and DOB is mediated predominantly by the 5-HT(2A) receptor-subtype, but that 5-HT(2B/C) receptors also play a minor role. Moreover, central and not peripheral mechanisms are involved. Given evidence that 5-HT(2) receptors are not located on 5-HT neurones, postsynaptic 5-HT feedback mechanisms are implicated.
[Mh] Termos MeSH primário: Núcleos da Rafe/fisiologia
Receptor 5-HT2A de Serotonina/fisiologia
Receptor 5-HT2B de Serotonina/fisiologia
Receptor 5-HT2C de Serotonina/fisiologia
[Mh] Termos MeSH secundário: Mistura de Alfaxalona Alfadolona
Animais
Hidrato de Cloral
Relação Dose-Resposta a Droga
Masculino
Núcleos da Rafe/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Serotonina/fisiologia
Agonistas de Receptores 5-HT2 de Serotonina
Agonistas de Receptores de Serotonina/farmacologia
Transmissão Sináptica/efeitos dos fármacos
Transmissão Sináptica/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptor, Serotonin, 5-HT2A); 0 (Receptor, Serotonin, 5-HT2B); 0 (Receptor, Serotonin, 5-HT2C); 0 (Serotonin 5-HT2 Receptor Agonists); 0 (Serotonin Receptor Agonists); 333DO1RDJY (Serotonin); 418M5916WG (Chloral Hydrate); 8067-82-1 (Alfaxalone Alfadolone Mixture)
[Em] Mês de entrada:0403
[Cu] Atualização por classe:140611
[Lr] Data última revisão:
140611
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030704
[St] Status:MEDLINE


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[PMID]:12655729
[Au] Autor:Ikemoto Y; Mashimo T
[Ti] Título:[Recent study on action mechanism of general anesthetics].
[So] Source:Masui;51 Suppl:S164-71, 2002 Dec.
[Is] ISSN:0021-4892
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Anestésicos Gerais/farmacologia
[Mh] Termos MeSH secundário: Mistura de Alfaxalona Alfadolona/farmacologia
Animais
Seres Humanos
Ativação do Canal Iônico/efeitos dos fármacos
Ligantes
Canais de Potássio Cálcio-Ativados/efeitos dos fármacos
Proteína Quinase C/metabolismo
Receptores de GABA/efeitos dos fármacos
Receptores de N-Metil-D-Aspartato/efeitos dos fármacos
Receptores de Serotonina/efeitos dos fármacos
Receptores 5-HT3 de Serotonina
Tremor
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anesthetics, General); 0 (Ligands); 0 (Potassium Channels, Calcium-Activated); 0 (Receptors, GABA); 0 (Receptors, N-Methyl-D-Aspartate); 0 (Receptors, Serotonin); 0 (Receptors, Serotonin, 5-HT3); 8067-82-1 (Alfaxalone Alfadolone Mixture); EC 2.7.11.13 (Protein Kinase C)
[Em] Mês de entrada:0306
[Cu] Atualização por classe:071115
[Lr] Data última revisão:
071115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030327
[St] Status:MEDLINE


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[PMID]:12429194
[Au] Autor:Ho SM; Waite PM
[Ad] Endereço:Developmental Neurobiology, Research School of Biological Sciences, Australian National University, Canberra, ACT 2601, Australia.
[Ti] Título:Effects of different anesthetics on the paired-pulse depression of the h reflex in adult rat.
[So] Source:Exp Neurol;177(2):494-502, 2002 Oct.
[Is] ISSN:0014-4886
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hyperreflexia is a common feature of spinal cord injury (SCI), and changes in reflex excitability have been reported to be useful in assessing treatments in animal models of cord damage. However, spinal reflexes are known to be dependent on anesthetic level. As a preliminary to its use in SCI, the excitability of the Hoffman reflex (H reflex) has been assessed under several commonly used anesthetics. The H reflex was recorded in the distal foot muscles (dorsal interossei) of adult rats, while the lateral plantar nerve was stimulated. Five different anesthetics were used: ketamine, halothane, Nembutal, Etomidate, and Saffan. Recording and stimulating electrodes were inserted directly through the skin to minimize the surgical procedure for each experiment, allowing repeated recording to be made in the same animal on a weekly basis. Suppression of the H reflex was tested using twin-pulse stimulation. Halothane and ketamine produced suppression of the H response when interpulse intervals were shortened to less than 1 s. The H-reflex suppression profiles recorded under Etomidate, Saffan, and Nembutal anesthesia were less sensitive to the stimulation rate, with little reduction until intervals were 200 ms or less. The suppression profiles of halothane and ketamine resemble that seen in unanesthetized humans, whereas that under the other anesthetics tried here resembles that observed in spinal-cord-injured animals. The results suggest a preferential action of some anesthetics on descending pathways involved in reflex modulation and the importance of assessing reflex excitability under anesthetics such as ketamine or halothane.
[Mh] Termos MeSH primário: Anestésicos/farmacologia
Reflexo H/efeitos dos fármacos
Reflexo H/fisiologia
Traumatismos da Medula Espinal/fisiopatologia
[Mh] Termos MeSH secundário: Administração por Inalação
Mistura de Alfaxalona Alfadolona/farmacologia
Animais
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Estimulação Elétrica/métodos
Eletrofisiologia
Etomidato/farmacologia
Halotano/farmacologia
Frequência Cardíaca/efeitos dos fármacos
Ketamina/farmacologia
Pentobarbital/farmacologia
Ratos
Ratos Wistar
Respiração/efeitos dos fármacos
Limiar Sensorial/efeitos dos fármacos
Limiar Sensorial/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anesthetics); 690G0D6V8H (Ketamine); 8067-82-1 (Alfaxalone Alfadolone Mixture); I4744080IR (Pentobarbital); UQT9G45D1P (Halothane); Z22628B598 (Etomidate)
[Em] Mês de entrada:0211
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:021114
[St] Status:MEDLINE


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[PMID]:11098097
[Au] Autor:Nadeson R; Goodchild CS
[Ad] Endereço:Department of Anaesthesia, Monash University, Victoria, Australia.
[Ti] Título:Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors.
[So] Source:Pain;88(1):31-9, 2000 Oct.
[Is] ISSN:0304-3959
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies have shown that the steroid anaesthetic alphaxalone positively modulates gamma-aminobutyric acid (GABA) receptors in vitro. It has also been reported that positive modulation of GABA(A) receptors in the rat spinal cord can produce antinociception in vivo. This present study looks at the interaction of an intraperitoneal injection (i.p.) of the steroid anaesthetic combination Saffan (alphaxalone 9 mg/ml, alphadolone acetate 3 mg/ml) with GABA(A) receptors in the spinal cord. Full recovery from anaesthesia induced by Saffan 2 ml/kg i.p., as assessed by the rotarod test, occurred after 28.78 +/- 0.86 min. Residual antinociceptive effects were assessed by application of electrical current at two skin sites (neck and tail) and also tail withdrawal from noxious heat. Residual antinociception was observed at both skin sites assessed by the electrical test but not when assessed by noxious heat. The antinociceptive effects in the tail but not the neck were suppressed by intrathecal administration of GABA(A) antagonists (bicuculline and SR-95531). In a separate group of experiments alphaxalone and alphadolone were given i.p. individually at the same doses that were given when formulated in Saffan. Alphaxalone produced sedative and anaesthetic effects with no antinociception. Alphadolone caused no sedation but it did cause antinociceptive effects equal in magnitude to those produced by Saffan. We conclude that Saffan produces antinociception in rats when given i.p. by an interaction with spinal GABA(A) receptors. Furthermore, this antinociception is due to the alphadolone content of the neurosteroid anaesthetic and not the alphaxalone.
[Mh] Termos MeSH primário: Mistura de Alfaxalona Alfadolona/farmacologia
Anestésicos/farmacologia
Nociceptores/efeitos dos fármacos
Pregnanodionas/farmacologia
Receptores de GABA-A/fisiologia
Medula Espinal/metabolismo
Esteroides/farmacologia
[Mh] Termos MeSH secundário: Mistura de Alfaxalona Alfadolona/antagonistas & inibidores
Anestésicos/antagonistas & inibidores
Animais
Bicuculina/farmacologia
Antagonistas GABAérgicos/farmacologia
Antagonistas de Receptores de GABA-A
Masculino
Medição da Dor
Piridazinas/farmacologia
Ratos
Ratos Wistar
Valores de Referência
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anesthetics); 0 (GABA Antagonists); 0 (GABA-A Receptor Antagonists); 0 (Pregnanediones); 0 (Pyridazines); 0 (Receptors, GABA-A); 0 (Steroids); 8067-82-1 (Alfaxalone Alfadolone Mixture); 99460MG420 (gabazine); BD07M97B2A (alphaxalone); OE1C96974E (alphadolone); Y37615DVKC (Bicuculline)
[Em] Mês de entrada:0103
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:001201
[St] Status:MEDLINE


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Fotocópia
[PMID]:10759388
[Au] Autor:Whelan G; James MF; Samson NA; Wood NI
[Ad] Endereço:SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.
[Ti] Título:Anaesthesia of the common marmoset (Callithrix jacchus) using continuous intravenous infusion of alphaxalone/alphadalone.
[So] Source:Lab Anim;33(1):24-9, 1999 Jan.
[Is] ISSN:0023-6772
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A safe means of anaesthetizing common marmosets (Callithrix jacchus) for a study using magnetic resonance imaging (MRI) to investigate cerebral ischaemia was required. Continuous infusion of alphaxalone/alphadalone was used to anaesthetize 37 marmosets for non-recovery and recovery experiments. This was found to give safe, reliable anaesthesia when coupled with pulse oximetry and electrocardiographic (ECG) monitoring.
[Mh] Termos MeSH primário: Mistura de Alfaxalona Alfadolona/administração & dosagem
Anestesia Intravenosa/veterinária
Callithrix/fisiologia
[Mh] Termos MeSH secundário: Mistura de Alfaxalona Alfadolona/farmacologia
Anestesia Intravenosa/métodos
Animais
Callithrix/cirurgia
Eletrocardiografia/veterinária
Feminino
Frequência Cardíaca/efeitos dos fármacos
Infusões Intravenosas/veterinária
Imagem por Ressonância Magnética/veterinária
Masculino
Oximetria/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
8067-82-1 (Alfaxalone Alfadolone Mixture)
[Em] Mês de entrada:0005
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000412
[St] Status:MEDLINE



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