Base de dados : MEDLINE
Pesquisa : D04.210.500.925 [Categoria DeCS]
Referências encontradas : 630 [refinar]
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[PMID]:28881317
[Au] Autor:Kaur Kohli S; Handa N; Bali S; Arora S; Sharma A; Kaur R; Bhardwaj R
[Ad] Endereço:Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India.
[Ti] Título:Modulation of antioxidative defense expression and osmolyte content by co-application of 24-epibrassinolide and salicylic acid in Pb exposed Indian mustard plants.
[So] Source:Ecotoxicol Environ Saf;147:382-393, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The study focuses on potential of combined pre-soaking treatment of 24-Epibrassinolide (EBL) and Salicylic acid (SA) in alleviating Pb phytotoxicity in Brassica juncea L. plants. The seeds after treatment with combination of both the hormones were sown in mixture of soil, sand and manure (3:1:1) and were exposed to Pb concentrations (0.25mM, 0.50mM and 0.75mM). After 30 days of growth, the plants were harvested and processed, for quantification of various metabolites. It was found that pre-sowing of seeds in combination of EBL and SA, mitigated the adverse effects of metal stress by modulating antioxidative defense response and enhanced osmolyte contents. Dry matter content and heavy metal tolerance index were enhanced in response to co-application of EBL and SA. The levels of superoxide anions, hydrogen peroxide and malondialdehyde were lowered by the combined treatment of hormones. Enhancement in activities of guaiacol peroxidase, catalase, glutathione reductase and glutathione-s-transferase were recorded. Contents of glutathione, tocopherol and ascorbic acid were also enhanced in response to co-application of both hormones. Expression of POD, CAT, GR and GST1 genes were up-regulated whereas SOD gene was observed to be down-regulated. Contents of proline, trehalose and glycine betaine were also reported to be elevated as a result of treatment with EBL+SA. The results suggest that co-application of EBL+SA may play an imperative role in improving the antioxidative defense expression of B. juncea plants to combat the oxidative stress generated by Pb toxicity.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Brassinosteroides/farmacologia
Poluentes Ambientais/toxicidade
Chumbo/toxicidade
Mostardeira/efeitos dos fármacos
Ácido Salicílico/farmacologia
Esteroides Heterocíclicos/farmacologia
[Mh] Termos MeSH secundário: Poluentes Ambientais/metabolismo
Expressão Gênica/efeitos dos fármacos
Hidroponia
Chumbo/metabolismo
Mostardeira/enzimologia
Mostardeira/genética
Osmorregulação/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Brassinosteroids); 0 (Environmental Pollutants); 0 (Steroids, Heterocyclic); 2P299V784P (Lead); O414PZ4LPZ (Salicylic Acid); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE


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[PMID]:29029379
[Au] Autor:Shahzad B; Tanveer M; Che Z; Rehman A; Cheema SA; Sharma A; Song H; Rehman SU; Zhaorong D
[Ad] Endereço:School of Land and Food, University of Tasmania, Hobart, Tasmania, Australia. Electronic address: bs_tahir786@yahoo.com.
[Ti] Título:Role of 24-epibrassinolide (EBL) in mediating heavy metal and pesticide induced oxidative stress in plants: A review.
[So] Source:Ecotoxicol Environ Saf;147:935-944, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Industrialization and urbanization have posed serious threats to the environment. Excessive release of heavy metals from industrial effluents and overuse of pesticides in modern agriculture are limiting crop production by polluting environment and deteriorating food quality. Sustaining food quality under heavy metals and pesticide stress is crucial to meet the increasing demands for food. 24-Epibrassinolide (EBL), a ubiquitously occurring plant growth hormone shows great potential to alleviate heavy metals and pesticide stress in plants. This review sums up the potential role of EBL in ameliorating heavy metals and pesticide toxicity in plants extensively. EBL application increases plant's overall growth, biomass accumulation and photosynthetic efficiency by the modulation of numerous biochemical and physiological processes under heavy metals and pesticide stress. In addition, EBL scavenges reactive oxygen species (ROS) by triggering the production of antioxidant enzymes such as SOD, CAT, POX etc. EBL also induces the production of proline and soluble proteins that helps in maintaining osmotic potential and osmo-protection under both heavy metals and pesticide stress. At the end, future needs of research about the application of 24-epibrassinolide have also been discussed.
[Mh] Termos MeSH primário: Brassinosteroides/farmacologia
Produtos Agrícolas/efeitos dos fármacos
Metais Pesados/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Praguicidas/toxicidade
Reguladores de Crescimento de Planta/farmacologia
Poluentes do Solo/toxicidade
Esteroides Heterocíclicos/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Produtos Agrícolas/metabolismo
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Brassinosteroids); 0 (Metals, Heavy); 0 (Pesticides); 0 (Plant Growth Regulators); 0 (Reactive Oxygen Species); 0 (Soil Pollutants); 0 (Steroids, Heterocyclic); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


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[PMID]:28461403
[Au] Autor:Sun C; Yan K; Han JT; Tao L; Lv MH; Shi T; He YX; Wierzba M; Tax FE; Li J
[Ad] Endereço:Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
[Ti] Título:Scanning for New BRI1 Mutations via TILLING Analysis.
[So] Source:Plant Physiol;174(3):1881-1896, 2017 Jul.
[Is] ISSN:1532-2548
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The identification and characterization of a mutational spectrum for a specific protein can help to elucidate its detailed cellular functions. BRASSINOSTEROID INSENSITIVE1 (BRI1), a multidomain transmembrane receptor-like kinase, is a major receptor of brassinosteroids in Arabidopsis ( ). Within the last two decades, over 20 different mutant alleles have been identified, which helped to determine the significance of each domain within BRI1. To further understand the molecular mechanisms of BRI1, we tried to identify additional alleles via targeted induced local lesions in genomes. Here, we report our identification of 83 new point mutations in , including nine mutations that exhibit an allelic series of typical phenotypes, from subtle to severe morphological alterations. We carried out biochemical analyses to investigate possible mechanisms of these mutations in affecting brassinosteroid signaling. A number of interesting mutations have been isolated via this study. For example, , the only weak allele identified so far with a mutation in the activation loop, showed reduced autophosphorylation activity. , a subtle allele with a mutation in the extracellular portion, disrupts the interaction of BRI1 with its ligand brassinolide and coreceptor BRI1-ASSOCIATED RECEPTOR KINASE1. , with a mutation in the extracellular portion, is a subtle defective mutant. Surprisingly, root inhibition analysis indicated that it is largely insensitive to exogenous brassinolide treatment. In this study, we found that possesses kinase activity in vivo, clarifying a previous report arguing that kinase activity may not be necessary for the function of BRI1. These data provide additional insights into our understanding of the early events in the brassinosteroid signaling pathway.
[Mh] Termos MeSH primário: Proteínas de Arabidopsis/genética
Arabidopsis/genética
Mutagênese/genética
Mutação/genética
Proteínas Quinases/genética
[Mh] Termos MeSH secundário: Alelos
Sequência de Aminoácidos
Arabidopsis/efeitos dos fármacos
Arabidopsis/metabolismo
Proteínas de Arabidopsis/química
Brassinosteroides/farmacologia
Sequência Conservada
Genes Dominantes
Teste de Complementação Genética
Simulação de Dinâmica Molecular
Fenótipo
Fosforilação/efeitos dos fármacos
Proteínas Quinases/química
Estrutura Secundária de Proteína
Transdução de Sinais/efeitos dos fármacos
Esteroides Heterocíclicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (Brassinosteroids); 0 (Steroids, Heterocyclic); EC 2.7.- (Protein Kinases); EC 2.7.11.1 (BRI1 protein, Arabidopsis); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1104/pp.17.00118


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[PMID]:28743039
[Au] Autor:Xu Z; Lei P; Pang X; Li H; Feng X; Xu H
[Ad] Endereço:Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, PR China. Electronic address: zqxu@njtech.edu.cn.
[Ti] Título:Exogenous application of poly-γ-glutamic acid enhances stress defense in Brassica napus L. seedlings by inducing cross-talks between Ca , H O , brassinolide, and jasmonic acid in leaves.
[So] Source:Plant Physiol Biochem;118:460-470, 2017 Sep.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Poly-γ-glutamic acid (γ-PGA) is a microbe-secreted isopeptide shown to promote growth and enhance crop stress tolerance. However, its downstream signaling pathways are unknown. Here, we studied γ-PGA-induced tolerance to salt and cold stresses. Pretreatment with γ-PGA contributed to enhance stress tolerance of canola seedlings by promoting proline accumulation and total antioxidant capacity (T-AOC) improvement. Further, Ca , H O , brassinolide, and jasmonic acid were found to be involved in the γ-PGA-induced process. First, using signal blockers, we concluded that γ-PGA activated Ca fluctuations in canola seedling leaves. Second, the activated Ca further elicited H O production by Ca -binding proteins CBL9, CPK4, and CPK5. Third, the H O signal promoted brassinolide and jasmonic acid biosynthesis by upregulating key genes (DWF4 and LOX2, respectively) for synthesizing these compounds. Lastly, brassinolide and jasmonic acid increased H O which promoted proline accumulation and T-AOC improvement and further enhanced Ca -binding proteins including CaM, CBL10, and CPK9.
[Mh] Termos MeSH primário: Brassica napus/metabolismo
Brassinosteroides/metabolismo
Sinalização do Cálcio/efeitos dos fármacos
Ciclopentanos/metabolismo
Peróxido de Hidrogênio/metabolismo
Oxilipinas/metabolismo
Folhas de Planta/metabolismo
Ácido Poliglutâmico/farmacologia
Plântulas/metabolismo
Esteroides Heterocíclicos/metabolismo
Estresse Fisiológico/efeitos dos fármacos
[Mh] Termos MeSH secundário: Cálcio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brassinosteroids); 0 (Cyclopentanes); 0 (Oxylipins); 0 (Steroids, Heterocyclic); 25513-46-6 (Polyglutamic Acid); 6RI5N05OWW (jasmonic acid); BBX060AN9V (Hydrogen Peroxide); SY7Q814VUP (Calcium); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


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[PMID]:28847728
[Au] Autor:Sadava D; Kane SE
[Ad] Endereço:Department of Cancer Biology, Beckman Research Institute of the City of Hope, 1500 East Duarte Rd., Duarte, CA 91010, USA. Electronic address: dsadava@coh.org.
[Ti] Título:The effect of brassinolide, a plant steroid hormone, on drug resistant small-cell lung carcinoma cells.
[So] Source:Biochem Biophys Res Commun;493(1):783-787, 2017 Nov 04.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Small-cell lung carcinoma (SCLC) has a dismal prognosis in part because of multidrug resistance (MDR). Epibrassinolide (EB) is a steroid hormone in plants, with many physiological effects. It acts via a membrane receptor and GSK3 pathway, resulting in stabilization of a transcription factor. The parallels to the Wnt signaling pathway, which is activated in SCLC and results in increased ß-catenin, prompted investigations of the effects of EB on drug-resistant (VPA17) and drug-sensitive (H69) SCLC cells. EB was cytotoxic to both cell lines (IC = 2 µM), indicating a lack of cross-resistance in the VPA17 cell line. EB was pro-apoptotic after 24 h as measured by ELISA of BUdR-labeled DNA fragments and caspase-3 specific activity (2.5 enzyme units/mg protein vs. 0.01 units/mg protein for untreated controls). Matrigel assays showed that EB reduced the SCLC cell invasion phenotype by 80%. Pre-incubation of VPA17 cells in 1 µM EB for 96 h reversed resistance to etoposide (IC = 6.0 µM, reduced to 1.8 µM with EB) and doxorubicin (IC = 0.37 µM, reduced to 0.09 µM). Synergism between EB and chemotherapy drugs was investigated by exposure of VPA17 cells to 1:1 ratios at the respective IC values, with serial dilutions at 0.25 to 2.0 × IC and determination of the combination index (CI). EB and etoposide showed synergism (CI = 0.80 at ED50); EB and doxorubicin also showed synergism (CI = 0.65 at ED50). Incubation of SCLC cells in EB led to a time- and dose dependent reduction of ß-catenin (maximum 80% reduction). Gene expression analyses of SCLC cells showed EB incubation resulted in significant reduction in expression of ß-catenin-dependent genes that are anti-apoptotic (e.g., c-Jun, survivin), cell division-related (e.g., CCND1 cyclin, sox9), and metastasis-related (e.g., MMP7, uPAR). WIKI4, a known inhibitor of Wnt signaling, was cytotoxic to SCLC cells (IC = 0.02 µM). Synergism between EB and WIKI4 was determined by the CI method and showed antagonism (CI = 1.09 at ED50), suggesting that EB and WIKI4 act on the same pathway. Taken together, these data indicate that EB, a natural product with widespread occurrence in plants, is pharmacologically active in both drug-sensitive and drug-resistant SCLC cells and acts through the Wnt signaling pathway.
[Mh] Termos MeSH primário: Brassinosteroides/administração & dosagem
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias Pulmonares/patologia
Reguladores de Crescimento de Planta
Carcinoma de Pequenas Células do Pulmão/tratamento farmacológico
Carcinoma de Pequenas Células do Pulmão/patologia
Esteroides Heterocíclicos/administração & dosagem
[Mh] Termos MeSH secundário: Antineoplásicos/administração & dosagem
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Seres Humanos
Fitosteróis/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Brassinosteroids); 0 (Phytosterols); 0 (Plant Growth Regulators); 0 (Steroids, Heterocyclic); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


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[PMID]:28751198
[Au] Autor:Watanabe B; Yamamoto S; Yokoi T; Sugiura A; Horoiwa S; Aoki T; Miyagawa H; Nakagawa Y
[Ad] Endereço:Chemistry of Molecular Biocatalysts, Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan.
[Ti] Título:Brassinolide-like activity of castasterone analogs with varied side chains against rice lamina inclination.
[So] Source:Bioorg Med Chem;25(17):4566-4578, 2017 Sep 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Brassinolide (BL) and castasterone (CS) are the representative members of brassinosteroid class of plant steroid hormone having plant growth promoting activity. In this study, eleven CS analogs bearing a variety of side chains were synthesized to determine the effect of the side chain structures on the BL-like activity. The plant hormonal activity was evaluated in a dwarf rice lamina inclination assay, and the potency was determined as the reciprocal logarithm of the 50% effective dose (ED ) from each dose-response curve. The reciprocal logarithm of ED (pED ) was decreased dramatically upon deletion of the C-28 methyl group of CS. The introduction of oxygen-containing groups such as hydroxy, methoxy, and ethoxycarbonyl was also unfavorable to the activity. The pED was influenced by the geometry of carbon-carbon double bond between C-24 and C-25 (cis and trans), but the introduction of a fluorine atom at the C-25 position of the double bond did not significantly change the activity. The binding free energy (ΔG) was calculated for all ligand-receptor binding interactions using molecular dynamics, resulting that ΔG is linearly correlated with the pED .
[Mh] Termos MeSH primário: Colestanóis/química
Reguladores de Crescimento de Planta/química
[Mh] Termos MeSH secundário: Sítios de Ligação
Brassinosteroides/química
Brassinosteroides/metabolismo
Brassinosteroides/farmacologia
Colestanóis/metabolismo
Colestanóis/farmacologia
Ligantes
Simulação de Acoplamento Molecular
Oryza/efeitos dos fármacos
Oryza/crescimento & desenvolvimento
Reguladores de Crescimento de Planta/metabolismo
Reguladores de Crescimento de Planta/farmacologia
Proteínas de Plantas/química
Proteínas de Plantas/metabolismo
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/crescimento & desenvolvimento
Estrutura Terciária de Proteína
Esteroides Heterocíclicos/química
Esteroides Heterocíclicos/metabolismo
Esteroides Heterocíclicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brassinosteroids); 0 (Cholestanols); 0 (Ligands); 0 (Plant Growth Regulators); 0 (Plant Proteins); 0 (Steroids, Heterocyclic); 80736-41-0 (castasterone); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE


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[PMID]:28668650
[Au] Autor:Tantawy MA; Nafie MS; Elmegeed GA; Ali IAI
[Ad] Endereço:Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt; TWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
[Ti] Título:Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs.
[So] Source:Bioorg Chem;73:128-146, 2017 Aug.
[Is] ISSN:1090-2120
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Steroids are polycyclic compounds that have a wide range of biological activities. They are bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so they are highly lipophilic and readily enter most cells to interact with intracellular receptors, making them ideal vehicles for targeting a broad array of pathologies. New curative agents for cancers have been developed from several steroidal derivatives. Some biologically important properties of modified steroids are dependent on structural features of the steroid moiety and their side chains. Therefore, chemical derivatization of steroids provides a way to modify their function, and many structure-activity relationships have been confirmed by such synthetic modifications. Several studies demonstrate that steroidal heterocyclic derivatives can be effective in the prevention and treatment of many types of hormone-dependent cancers. The present review is a concise report on steroidal heterocyclic derivatives, with special emphasis on steroid heterocyclic derivatives with 5 membered rings or six-membered rings having interesting therapeutic potential as enzyme inhibitors and cytotoxic drugs to be used as candidates for anti-cancer drug development.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Esteroides Heterocíclicos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/síntese química
Antineoplásicos/química
Proliferação Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Conformação Molecular
Esteroides Heterocíclicos/síntese química
Esteroides Heterocíclicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Steroids, Heterocyclic)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


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[PMID]:28644899
[Au] Autor:Waisi H; Jankovic B; Jankovic M; Nikolic B; Dimkic I; Lalevic B; Raicevic V
[Ad] Endereço:Department of Scientific Research and Information Technology, Institute for the Development of Water Resources "Jaroslav Cerni", Belgrade, Serbia.
[Ti] Título:New insights in dehydration stress behavior of two maize hybrids using advanced distributed reactivity model (DRM). Responses to the impact of 24-epibrassinolide.
[So] Source:PLoS One;12(6):e0179650, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Proposed distributed reactivity model of dehydration for seedling parts of two various maize hybrids (ZP434, ZP704) was established. Dehydration stresses were induced thermally, which is also accompanied by response of hybrids to heat stress. It was found that an increased value of activation energy counterparts within radicle dehydration of ZP434, with a high concentration of 24-epibrassinolide (24-EBL) at elevated operating temperatures, probably causes activation of diffusion mechanisms in cutin network and may increases likelihood of formation of free volumes, large enough to accommodate diffusing molecule. Many small random effects were detected and can be correlated with micro-disturbing in a space filled with water caused by thermal gradients, increasing capillary phenomena, and which can induce thermo-capillary migration. The influence of seedling content of various sugars and minerals on dehydration was also examined. Estimated distributed reactivity models indicate a dependence of reactivity on structural arrangements, due to present interactions between water molecules and chemical species within the plant.
[Mh] Termos MeSH primário: Modelos Biológicos
Plântulas/fisiologia
Estresse Fisiológico
Zea mays/fisiologia
[Mh] Termos MeSH secundário: Brassinosteroides/metabolismo
Desidratação
Temperatura Alta
Lipídeos de Membrana/metabolismo
Proteínas de Plantas/metabolismo
Plântulas/anatomia & histologia
Sementes/anatomia & histologia
Sementes/fisiologia
Especificidade da Espécie
Esteroides Heterocíclicos/metabolismo
Água/metabolismo
Zea mays/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brassinosteroids); 0 (Membrane Lipids); 0 (Plant Proteins); 0 (Steroids, Heterocyclic); 059QF0KO0R (Water); 54990-88-4 (cutin); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179650


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[PMID]:28600178
[Au] Autor:Chen E; Wang X; Gong Q; Butt HI; Chen Y; Zhang C; Yang Z; Wu Z; Ge X; Zhang X; Li F; Zhang X
[Ad] Endereço:State Key Laboratory of Cotton Biology, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang 455000, China; Huazhong Agricultural University, Wuhan 430070, China.
[Ti] Título:A novel GhBEE1-Like gene of cotton causes anther indehiscence in transgenic Arabidopsis under uncontrolled transcription level.
[So] Source:Gene;627:49-56, 2017 Sep 05.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Male-sterile lines are very important for selective breeding, and anther dehiscence defect is an effective way to generate male-sterile lines. Although several bHLH-family proteins in Arabidopsis have been characterized, little is known about the role of bHLH-family proteins in cotton. Here, we isolated a novel bHLH protein from cotton (Gossypium hirsutum), named GhBEE1-Like. Protein domain analysis showed that GhBEE1-Like contained a basic domain and an HLH domain. Subcellular localization analysis revealed that GhBEE1-Like was a nuclear-localized protein. Expression pattern analysis showed GhBEE1-Like was highly expressed in floral organs, and its expression was induced by the active brassinosteroid (BR) substance 24-epi-BL. GhBEE1-Like overexpression in Arabidopsis resulted in two types of transgenic lines, one with normal anther dehiscence and the other with defective anther dehiscence. Semi-qRT-PCR and qRT-PCR analyses revealed that GhBEE1-Like transcript levels acted as a check-point determining how anther dehiscence proceeds in these transgenic lines; regulated transcript levels result in normal anther dehiscence, whereas uncontrolled transcript levels lead to anther indehiscence. These results suggest that GhBEE1-Like plays an important role via its accumulation in regulating anther dehiscence. Therefore, controlling the level of GhBEE1-Like expression in cotton could be a convenient tool for generating male-sterile lines to use in selective breeding.
[Mh] Termos MeSH primário: Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/genética
Flores/metabolismo
Gossypium/genética
Proteínas de Plantas/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Arabidopsis/genética
Arabidopsis/fisiologia
Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/química
Brassinosteroides/metabolismo
Clonagem Molecular
Filogenia
Reguladores de Crescimento de Planta/metabolismo
Proteínas de Plantas/química
Proteínas de Plantas/metabolismo
Plantas Geneticamente Modificadas/genética
Pólen/metabolismo
Alinhamento de Sequência
Esteroides Heterocíclicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors); 0 (Brassinosteroids); 0 (Plant Growth Regulators); 0 (Plant Proteins); 0 (Steroids, Heterocyclic); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE


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[PMID]:28575660
[Au] Autor:Zhu JY; Li Y; Cao DM; Yang H; Oh E; Bi Y; Zhu S; Wang ZY
[Ad] Endereço:Department of Plant Biology, Carnegie Institution for Science, Stanford, CA 94305, USA.
[Ti] Título:The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis.
[So] Source:Mol Cell;66(5):648-657.e4, 2017 Jun 01.
[Is] ISSN:1097-4164
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The glycogen synthase kinase-3 (GSK3) family kinases are central cellular regulators highly conserved in all eukaryotes. In Arabidopsis, the GSK3-like kinase BIN2 phosphorylates a range of proteins to control broad developmental processes, and BIN2 is degraded through unknown mechanism upon receptor kinase-mediated brassinosteroid (BR) signaling. Here we identify KIB1 as an F-box E3 ubiquitin ligase that promotes the degradation of BIN2 while blocking its substrate access. Loss-of-function mutations of KIB1 and its homologs abolished BR-induced BIN2 degradation and caused severe BR-insensitive phenotypes. KIB1 directly interacted with BIN2 in a BR-dependent manner and promoted BIN2 ubiquitination in vitro. Expression of an F-box-truncated KIB1 caused BIN2 accumulation but dephosphorylation of its substrate BZR1 and activation of BR responses because KIB1 blocked BIN2 binding to BZR1. Our study demonstrates that KIB1 plays an essential role in BR signaling by inhibiting BIN2 through dual mechanisms of blocking substrate access and promoting degradation.
[Mh] Termos MeSH primário: Proteínas de Arabidopsis/metabolismo
Arabidopsis/efeitos dos fármacos
Brassinosteroides/farmacologia
Proteínas F-Box/metabolismo
Quinase 3 da Glicogênio Sintase/metabolismo
Reguladores de Crescimento de Planta/farmacologia
Plantas Geneticamente Modificadas/efeitos dos fármacos
Proteínas Quinases/metabolismo
Esteroides Heterocíclicos/farmacologia
Ubiquitina-Proteína Ligases/metabolismo
[Mh] Termos MeSH secundário: Arabidopsis/enzimologia
Arabidopsis/genética
Proteínas de Arabidopsis/genética
Sítios de Ligação
Domínio Catalítico
Ativação Enzimática
Estabilidade Enzimática
Proteínas F-Box/genética
Genótipo
Quinase 3 da Glicogênio Sintase/genética
Mutação
Proteínas Nucleares/genética
Proteínas Nucleares/metabolismo
Fenótipo
Plantas Geneticamente Modificadas/enzimologia
Plantas Geneticamente Modificadas/genética
Complexo de Endopeptidases do Proteassoma/metabolismo
Ligação Proteica
Proteínas Quinases/genética
Proteólise
Transdução de Sinais/efeitos dos fármacos
Especificidade por Substrato
Ubiquitina-Proteína Ligases/genética
Ubiquitinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (BZR1 protein, Arabidopsis); 0 (Brassinosteroids); 0 (F-Box Proteins); 0 (KIB1 protein, Arabidopsis); 0 (Nuclear Proteins); 0 (Plant Growth Regulators); 0 (Steroids, Heterocyclic); EC 2.3.2.27 (Ubiquitin-Protein Ligases); EC 2.7.- (Protein Kinases); EC 2.7.1.- (BIN2 protein, Arabidopsis); EC 2.7.11.1 (BRI1 protein, Arabidopsis); EC 2.7.11.26 (Glycogen Synthase Kinase 3); EC 3.4.25.1 (Proteasome Endopeptidase Complex); Y9IQ1L53OX (brassinolide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE



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