Base de dados : MEDLINE
Pesquisa : D04.345.051 [Categoria DeCS]
Referências encontradas : 85 [refinar]
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[PMID]:27984704
[Au] Autor:Kowalski M; Jarosz S
[Ad] Endereço:Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, 01-224, Warsaw, Poland.
[Ti] Título:Synthesis of aza-crown analogues and macrocyclic bis-lactams with sucrose scaffold.
[So] Source:Carbohydr Res;438:44-57, 2017 Jan 13.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:2,3,3',4,4'-Penta-O-benzylsucrose was converted into the corresponding diaminoalcohol which was used as a key building block in the synthesis of the analogues of aza-crown ethers and bis-lactams.
[Mh] Termos MeSH primário: Coronantes/síntese química
Lactamas Macrocíclicas/síntese química
Sacarose/química
[Mh] Termos MeSH secundário: Catálise
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Crown Compounds); 0 (Lactams, Macrocyclic); 57-50-1 (Sucrose)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170216
[Lr] Data última revisão:
170216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27611563
[Au] Autor:Negin S; Patel MB; Gokel MR; Meisel JW; Gokel GW
[Ad] Endereço:Department of Chemistry and Biochemistry, University of Missouri, 1 University Blvd., St. Louis, MO, 63121, USA.
[Ti] Título:Antibiotic Potency against E. coli Is Enhanced by Channel-Forming Alkyl Lariat Ethers.
[So] Source:Chembiochem;17(22):2153-2161, 2016 Nov 17.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Several N,N'-bis(n-alkyl-4,13-diaza[18]crown-6) lariat ethers were found to significantly enhance the potency of rifampicin and tetracycline, but not erythromycin and kanamycin, against the non-pathogenic DH5α and K-12 strains of Escherichia coli when administered at levels below their minimum inhibitory concentrations (MICs). The enhancements in antibiotic potency observed for the lariat ethers ranged from three- to 20-fold, depending on the strain of E. coli, the antibiotic, and the lengths of the alkyl chains attached at the macroring nitrogen atoms. The dialkyl lariat ethers, previously thought to only be cation carriers, formed well-behaved, ion-conducting pores in soybean asolectin membranes, as judged by planar bilayer conductance measurements. The ability of lariat ethers to form stable pores, which appeared to be aggregated, depended in part on alkyl chain length and in part on the composition of the bilayer membrane in which they were studied.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Coronantes/química
Escherichia coli/efeitos dos fármacos
Éteres/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/metabolismo
Escherichia coli/crescimento & desenvolvimento
Éteres/metabolismo
Éteres/farmacologia
Bicamadas Lipídicas/química
Bicamadas Lipídicas/metabolismo
Testes de Sensibilidade Microbiana
Rifampina/química
Rifampina/farmacologia
Tetraciclina/química
Tetraciclina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Crown Compounds); 0 (Ethers); 0 (Lipid Bilayers); F8VB5M810T (Tetracycline); VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201600428


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[PMID]:27337002
[Au] Autor:Ogoshi T; Yamagishi TA; Nakamoto Y
[Ad] Endereço:Graduate School of Natural Science and Technology, Kanazawa University , Kakuma-machi, Kanazawa 920-1192, Japan.
[Ti] Título:Pillar-Shaped Macrocyclic Hosts Pillar[n]arenes: New Key Players for Supramolecular Chemistry.
[So] Source:Chem Rev;116(14):7937-8002, 2016 07 27.
[Is] ISSN:1520-6890
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In 2008, we reported a new class of pillar-shaped macrocyclic hosts, known as "pillar[n]arenes". Today, pillar[n]arenes are recognized as key players in supramolecular chemistry because of their facile synthesis, unique pillar shape, versatile functionality, interesting host-guest properties, and original supramolecular assembly characteristics, which have resulted in numerous electrochemical and biomedical material applications. In this Review, we have provided historical background to macrocyclic chemistry, followed by a detailed discussion of the fundamental properties of pillar[n]arenes, including their synthesis, structure, and host-guest properties. Furthermore, we have discussed the applications of pillar[n]arenes to materials science, as well as their applications in supramolecular chemistry, in terms of their fundamental properties. Finally, we have described the future perspectives of pillar[n]arene chemistry. We hope that this Review will provide a useful reference for researchers working in the field and inspire discoveries concerning pillar[n]arene chemistry.
[Mh] Termos MeSH primário: Compostos Macrocíclicos/química
Compostos Macrocíclicos/síntese química
Éteres Fenílicos/química
Éteres Fenílicos/síntese química
[Mh] Termos MeSH secundário: Hidrocarbonetos Aromáticos com Pontes/síntese química
Hidrocarbonetos Aromáticos com Pontes/química
Calixarenos/síntese química
Calixarenos/química
Coronantes/síntese química
Coronantes/química
Ciclodextrinas/síntese química
Ciclodextrinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Bridged-Ring Compounds); 0 (Crown Compounds); 0 (Cyclodextrins); 0 (Macrocyclic Compounds); 0 (Phenyl Ethers); 130036-26-9 (Calixarenes)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrev.5b00765


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[PMID]:26826794
[Au] Autor:Porwanski S; Moretti F; Dumarcay-Charbonnier F; Marsura A
[Ad] Endereço:Department of Organic and Applied Chemistry, University of Lodz, ul. Tamka 12, 91-403 Lodz, Poland. Electronic address: porwany@chemul.uni.lodz.pl.
[Ti] Título:Cesium cation templated selective synthesis of a "cone-shaped" sugar macrotricyclic cryptand: A dual anion-cation molecular recognition of potassium tartrate.
[So] Source:Ann Pharm Fr;74(3):198-204, 2016 May.
[Is] ISSN:0003-4509
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Cesium templated Staudinger-aza-Wittig tandem reaction (S.A.W.) has been used in the synthesis of a bis-diazacrown-bis-cellobiosyl-tetra-ureido cryptand. A novel macrotricyclic compound having a "cone-shaped" configuration was selectively obtained. Additionally, first results on potential recognition properties of the cryptand are also given.
[Mh] Termos MeSH primário: Césio/química
Éteres Cíclicos/química
Compostos Policíclicos/química
Bases de Schiff/química
Tartaratos/química
[Mh] Termos MeSH secundário: Compostos Aza/química
Cátions/química
Coronantes/química
Modelos Moleculares
Conformação Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aza Compounds); 0 (Cations); 0 (Crown Compounds); 0 (Ethers, Cyclic); 0 (Polycyclic Compounds); 0 (Schiff Bases); 0 (Tartrates); 0 (cryptand); 1KSV9V4Y4I (Cesium); W4888I119H (tartaric acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160201
[St] Status:MEDLINE


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[PMID]:26687022
[Au] Autor:Rajczak E; Gluszynska A; Juskowiak B
[Ad] Endereço:Adam Mickiewicz University in Poznan, Faculty of Chemistry, Umultowska 89b, 61-614 Poznan, Poland.
[Ti] Título:Interaction of metallacrown complexes with G-quadruplex DNA.
[So] Source:J Inorg Biochem;155:105-14, 2016 Feb.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Interactions of the G-quadruplex (GQ) DNA with two pentacoordinate lanthanide (III) metallacrown (MC) complexes containing phenylalanine hydroxamic acid (pheHA) and copper(II) ions of the formula Eu 15-[MCCu,pheHA]-5 (1) and Tb 15-[MCCu,pheHA]-5 (2) were investigated. Binding of both metallacrowns to human telomeric G-quadruplex DNA was followed using CD spectroscopy, DNA melting profiles, and fluorescent intercalator displacement (FID) assay. A new G-quadruplex binding assay based of quenching of Tb(III)-GQ luminescence was proposed and evaluated. All performed tests confirmed interactions of MCs with studied GQ structure. Binding affinities of MCs were appreciable (KMC ~2-5×10(5)M(-1)). Higher concentration of MCs (the ratio of GQ:MC above 2.5) caused destabilization of tetraplex structure of GQ as evidenced by CD spectroscopy, melting temperatures, and Tb(III)-GQ luminescence quenching results.
[Mh] Termos MeSH primário: Coronantes/química
DNA/química
Quadruplex G
Elementos da Série dos Lantanídeos/química
[Mh] Termos MeSH secundário: Dicroísmo Circular
Seres Humanos
Espectrometria de Fluorescência
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Crown Compounds); 0 (Lanthanoid Series Elements); 9007-49-2 (DNA)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151228
[Lr] Data última revisão:
151228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE


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[PMID]:26521433
[Au] Autor:Gao CZ; Zhang Y; Chen J; Fei F; Wang TS; Yang B; Dong P; Zhang YJ
[Ti] Título:[Research progress of the drug delivery system of antitumor platinum drugs with macrocyclic compounds].
[So] Source:Yao Xue Xue Bao;50(6):650-7, 2015 Jun.
[Is] ISSN:0513-4870
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Platinum-based anticancer drugs have been becoming one of the most effective drugs for clinical treatment of malignant tumors for its unique mechanism of action and broad range of anticancer spectrum. But, there are still several problems such as side effects, drug resistance/cross resistance and no-specific targeting, becoming obstacles to restrict its expanding of clinical application. In recent years, supramolecular chemistry drug delivery systems have been gradually concerned for their favorable safety and low toxicity. Supramolecular macrocycles-platinum complexes increased the water solubility, stability and safety of traditional platinum drugs, and have become hot focus of developing novel platinum-based anticancer drugs because of its potential targeting of tumor tissues/organs. This article concentrates in the research progress of the new drug delivery system between platinum-based anticancer drugs with three generations of macrocycles: crown ether, cyclodextrin, cucurbituril and calixarene.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Sistemas de Liberação de Medicamentos
Compostos Macrocíclicos/farmacologia
Compostos de Platina/farmacologia
[Mh] Termos MeSH secundário: Calixarenos
Coronantes
Ciclodextrinas
Seres Humanos
Neoplasias/tratamento farmacológico
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Crown Compounds); 0 (Cyclodextrins); 0 (Macrocyclic Compounds); 0 (Platinum Compounds); 0 (cucurbituril); 130036-26-9 (Calixarenes)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151102
[Lr] Data última revisão:
151102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151103
[St] Status:MEDLINE


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[PMID]:26340444
[Au] Autor:Liu Q; Xiao K; Wen L; Lu H; Liu Y; Kong XY; Xie G; Zhang Z; Bo Z; Jiang L
[Ad] Endereço:Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, Beijing Normal University , Beijing 100875, PR China.
[Ti] Título:Engineered Ionic Gates for Ion Conduction Based on Sodium and Potassium Activated Nanochannels.
[So] Source:J Am Chem Soc;137(37):11976-83, 2015 Sep 23.
[Is] ISSN:1520-5126
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In living systems, ion conduction plays a major role in numerous cellular processes and can be controlled by biological ion channels in response to specific environmental stimuli. This article describes biomimetic ionic gates for ion conduction based on sodium and potassium activated nanochannels. The Na(+) activated ionic gate and K(+) activated ionic gate were developed by immobilizing the alkali metal cation-responsive functional molecules, 4'-aminobenzo-15-crown-5 and 4'-aminobenzo-18-crown-6, respectively, onto the conical polyimide nanochannels. When the ionic gate was in the presence of the specific alkali metal cation, positively charged complexes formed between the crown ether and the alkali metal cation. On the basis of the resulting changes in surface charge, wettability and effective pore size, the nanochannel can achieve reversible switching. The switching behaviors of the two complexes differed due to the differences in binding strength between the two complexes. The Na(+) activated ionic gate is able to open and close to control the ion conduction through the nanochannel, and the K(+) activated ionic gate enables selective cation and anion conduction through the nanochannel. The Na(+) and K(+) activated ionic gates show great promise for use in clinical medicine, biosensors and drug delivery based on their high sensitivity and selectivity of being activated, and good stability.
[Mh] Termos MeSH primário: Materiais Biomiméticos/química
Ativação do Canal Iônico
Nanotecnologia/métodos
Potássio/química
Sódio/química
[Mh] Termos MeSH secundário: Compostos de Anilina/química
Coronantes/química
Éteres de Coroa/química
Condutividade Elétrica
Modelos Moleculares
Conformação Molecular
Molhabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (4'-aminobenzo-15-crown-5); 0 (Aniline Compounds); 0 (Crown Compounds); 0 (Crown Ethers); 63J177NC5B (18-crown-6); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150923
[Lr] Data última revisão:
150923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150905
[St] Status:MEDLINE
[do] DOI:10.1021/jacs.5b04911


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[PMID]:26051600
[Au] Autor:Mariappan K; Alaparthi M; Hoffman M; Rama MA; Balasubramanian V; John DM; Sykes AG
[Ad] Endereço:Department of Chemistry, University of South Dakota, Vermillion, SD 57069, USA. mkadarka@usd.edu.
[Ti] Título:Improved selectivity for Pb(II) by sulfur, selenium and tellurium analogues of 1,8-anthraquinone-18-crown-5: synthesis, spectroscopy, X-ray crystallography and computational studies.
[So] Source:Dalton Trans;44(26):11774-87, 2015 Jul 14.
[Is] ISSN:1477-9234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We report here a series of heteroatom-substituted macrocycles containing an anthraquinone moiety as a fluorescent signaling unit and a cyclic polyheteroether chain as the receptor. Sulfur, selenium, and tellurium derivatives of 1,8-anthraquinone-18-crown-5 (1) were synthesized by reacting sodium sulfide (Na2S), sodium selenide (Na2Se) and sodium telluride (Na2Te) with 1,8-bis(2-bromoethylethyleneoxy)anthracene-9,10-dione in a 1 : 1 ratio. The optical properties of the new compounds are examined and the sulfur and selenium analogues produce an intense green emission enhancement upon association with Pb(II) in acetonitrile. Selectivity for Pb(II) is markedly improved as compared to the oxygen analogue 1 which was also competitive for Ca(II) ion. UV-Visible and luminescence titrations reveal that 2 and 3 form 1 : 1 complexes with Pb(II), confirmed by single-crystal X-ray studies where Pb(II) is complexed within the macrocycle through coordinate covalent bonds to neighboring carbonyl, ether and heteroether donor atoms. Cyclic voltammetry of 2-8 showed classical, irreversible oxidation potentials for sulfur, selenium and tellurium heteroethers in addition to two one-electron reductions for the anthraquinone carbonyl groups. DFT calculations were also conducted on 1, 2, 3, 6, 6 + Pb(II) and 6 + Mg(II) to determine the trend in energies of the HOMO and the LUMO levels along the series.
[Mh] Termos MeSH primário: Antraquinonas/química
Coronantes/química
Chumbo/química
Selênio/química
Enxofre/química
Telúrio/química
[Mh] Termos MeSH secundário: Antraquinonas/síntese química
Coronantes/síntese química
Cristalografia por Raios X
Compostos Macrocíclicos/síntese química
Compostos Macrocíclicos/química
Modelos Moleculares
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Crown Compounds); 0 (Macrocyclic Compounds); 030MS0JBDO (9,10-anthraquinone); 2P299V784P (Lead); 70FD1KFU70 (Sulfur); H6241UJ22B (Selenium); NQA0O090ZJ (Tellurium)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150624
[Lr] Data última revisão:
150624
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150609
[St] Status:MEDLINE
[do] DOI:10.1039/c5dt01305d


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[PMID]:25728935
[Au] Autor:Sharma N; Reja SI; Bhalla V; Kumar M
[Ad] Endereço:Department of Chemistry, UGC Sponsored Centre for Advance Studies-1, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
[Ti] Título:A thiacalix[4]crown based chemosensor for Zn²âº and H2PO4⁻: sequential logic operations at the molecular level.
[So] Source:Dalton Trans;44(13):6062-8, 2015 Apr 07.
[Is] ISSN:1477-9234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A thiacalix[4]crown based di-topic receptor 3 possessing two types of binding sites viz. crown-5 ring and imino moieties has been synthesized which undergoes fluorescence enhancement in the presence of Zn(2+) ions. The selective binding of Zn(2+) to compound 3 does not allow the K(+) ions to bind with the crown-5 ring and thus a negative allosteric behaviour has been observed between Zn(2+)/K(+) ions. In addition, the 3-Zn(2+) complex can be used for the detection of H2PO4(-) ions with a fluorescence "turn-off" response. Furthermore, based on the fluorescence response, a two input and one output sequential logic circuit has been constructed.
[Mh] Termos MeSH primário: Coronantes/síntese química
Corantes Fluorescentes/síntese química
Ácidos Fosfóricos/análise
Zinco/análise
[Mh] Termos MeSH secundário: Regulação Alostérica
Coronantes/química
Corantes Fluorescentes/química
Iminas/química
Estrutura Molecular
Ácidos Fosfóricos/química
Potássio/química
Espectrometria de Fluorescência
Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Crown Compounds); 0 (Fluorescent Dyes); 0 (Imines); 0 (Phosphoric Acids); J41CSQ7QDS (Zinc); RWP5GA015D (Potassium)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150318
[Lr] Data última revisão:
150318
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150303
[St] Status:MEDLINE
[do] DOI:10.1039/c5dt00082c


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[PMID]:25425355
[Au] Autor:Wang W; Li GP; Wang SF; Shi ZF; Cao XP
[Ad] Endereço:State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 (P. R. China).
[Ti] Título:Direct and short construction of the ACDE ring system of daphenylline.
[So] Source:Chem Asian J;10(2):377-82, 2015 Feb.
[Is] ISSN:1861-471X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Daphenylline, a novel daphniphyllum alkaloid, boasts a fused and bridging ring system coupled with six stereogenic centers. Here we present a direct and short construction of the ACDE ring system of daphenylline from the known 3-(2-bromophenyl)propanal in 10 steps and 17 % overall yield. The synthesis features an iron(III)-catalyzed aza-Cope-Mannich reaction, a self-terminating 6-exo-trig aryl radical-alkene cyclization and an intramolecular Friedel-Crafts acylation.
[Mh] Termos MeSH primário: Alcaloides/química
[Mh] Termos MeSH secundário: Acilação
Aldeídos/química
Alcaloides/síntese química
Alcenos/química
Catálise
Coronantes/química
Cristalografia por Raios X
Ciclização
Compostos Férricos/química
Conformação Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aldehydes); 0 (Alkaloids); 0 (Alkenes); 0 (Crown Compounds); 0 (Ferric Compounds); 0 (daphenylline); AMJ2B4M67V (propionaldehyde)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150123
[Lr] Data última revisão:
150123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141127
[St] Status:MEDLINE
[do] DOI:10.1002/asia.201403152



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