Base de dados : MEDLINE
Pesquisa : D04.345.566.050 [Categoria DeCS]
Referências encontradas : 1539 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 154 ir para página                         

  1 / 1539 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28895390
[Au] Autor:Woloszyn A; Kotlowski R
[Ad] Endereço:Gdansk University of Technology, Department of Molecular Biotechnology and Microbiology, Gdansk, Poland
[Ti] Título:A universal method for the identification of genes encoding amatoxins and phallotoxins in poisonous mushrooms
[So] Source:Rocz Panstw Zakl Hig;68(3):247-251, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: As the currently known diagnostic DNA targets amplified in the PCR assays for detection of poisonous mushrooms have their counterparts in edible species, there is a need to design PCR primers specific to the genes encoding amanitins and phallotoxins, which occur only in poisonous mushrooms. Objective: The aim of the study was testing of PCR-based method for detection of all genes encoding hepatotoxic cyclic peptides - amanitins and phallotoxins present in the most dangerous poisonous mushrooms. Material and Methods: Degenerate primers in the PCR were designed on the basis of amanitins (n=13) and phallotoxins (n=5) genes in 18 species of poisonous mushrooms deposited to Genbank of the National Center for Biotechnology Information. Results: The specificity of the PCR assays was confirmed against 9 species of edible mushrooms, death cap - Amanita phalloides and panther cap - Amanita pantherina. Conclusions: Designed two couples of PCR-primers specific to amanitins and phallotoxins genes can be recommended for detection of Amanita phalloides and other mushroom species producing hepatotoxic cyclic peptides - amanitins and phallotoxins.
[Mh] Termos MeSH primário: Amanita/química
Amanitinas/química
Intoxicação Alimentar por Cogumelos
[Mh] Termos MeSH secundário: Amanitinas/toxicidade
Cromatografia Líquida de Alta Pressão
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amanitins); 54351-96-1 (phallotoxin); 58250-15-0 (amatoxin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE


  2 / 1539 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28184019
[Au] Autor:Ma KW; Chok KS; Chan CK; Dai WC; Sin SL; Lau FL; Chan SC; Lo CM
[Ad] Endereço:Department of Surgery, Queen Mary Hospital, Pokfulam, Hong Kong.
[Ti] Título:Liver transplantation: a life-saving procedure following amatoxin mushroom poisoning.
[So] Source:Hong Kong Med J;23(1):93-6, 2017 Feb.
[Is] ISSN:1024-2708
[Cp] País de publicação:China
[La] Idioma:eng
[Mh] Termos MeSH primário: Encefalopatia Hepática/cirurgia
Transplante de Fígado
Intoxicação Alimentar por Cogumelos/cirurgia
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Idoso
Amanitinas/toxicidade
Feminino
Escala de Coma de Glasgow
Encefalopatia Hepática/etiologia
Hong Kong
Seres Humanos
Masculino
Meia-Idade
Intoxicação Alimentar por Cogumelos/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amanitins); 58250-15-0 (amatoxin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.12809/hkmj154616


  3 / 1539 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27476461
[Au] Autor:Tang S; Zhou Q; He Z; Luo T; Zhang P; Cai Q; Yang Z; Chen J; Chen Z
[Ad] Endereço:College of Life Science, Hunan Normal University, Changsha 410081, China.
[Ti] Título:Cyclopeptide toxins of lethal amanitas: Compositions, distribution and phylogenetic implication.
[So] Source:Toxicon;120:78-88, 2016 Sep 15.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lethal amanitas (Amanita sect. Phalloideae) are responsible for 90% of all fatal mushroom poisonings. Since 2000, more than ten new lethal Amanita species have been discovered and some of them had caused severe mushroom poisonings in China. However, the contents and distribution of cyclopeptides in these lethal mushrooms remain poorly known. In this study, the diversity of major cyclopeptide toxins in seven Amanita species from Eastern Asia and three species from Europe and North America were systematically analyzed, and a new approach to inferring phylogenetic relationships using cyclopeptide profile was evaluated for the first time. The results showed that there were diversities of the cyclopeptides among lethal Amanita species, and cyclopeptides from Amanita rimosa and Amanita fuligineoides were reported for the first time. The amounts of amatoxins in East Asian Amanita species were significantly higher than those in European and North American species. The analysis of distribution of amatoxins and phallotoxins in various Amanita species demonstrated that the content of phallotoxins was higher than that of amatoxins in Amanita phalloides and Amanita virosa. In contrast, the content of phallotoxins was significantly lower than that of amatoxins in all East Asian lethal Amanita species tested. However, the distribution of amatoxins and phallotoxins in different tissues showed the same tendency. Eight cyclopeptides and three unknown compounds were identified using cyclopeptide standards and high-resolution MS. Based on the cyclopeptide profiles, phylogenetic relationships of lethal amanitas were inferred through a dendrogram generated by UPGMA method. The results showed high similarity to the phylogeny established previously based on the multi-locus DNA sequences.
[Mh] Termos MeSH primário: Amanita/química
Amanitinas/toxicidade
Intoxicação Alimentar por Cogumelos
Peptídeos Cíclicos/química
Filogenia
[Mh] Termos MeSH secundário: Amanita/classificação
Cromatografia Líquida de Alta Pressão
Espectrometria de Massas
Peptídeos Cíclicos/classificação
Peptídeos Cíclicos/toxicidade
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amanitins); 0 (Peptides, Cyclic); 58250-15-0 (amatoxin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE


  4 / 1539 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27394089
[Au] Autor:Tan L; He R; Li Y; Liang Y; Li H; Tang Y
[Ad] Endereço:MOE Key Laboratory of Laser Life Science, South China Normal University, Guangzhou 510006, China; Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China. Electronic address: jsutanlei@gmail.com.
[Ti] Título:Fabrication of a biomimetic adsorbent imprinted with a common specificity determinant for the removal of α- and ß-amanitin from plasma.
[So] Source:J Chromatogr A;1459:1-8, 2016 Aug 12.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:α-Amanitin and ß-amanitin are the main toxins of mushroom poisoning. The application of traditional non-selective adsorbents is not satisfactory in clinical treatment of amanita mushroom poisoning due to lack of specificity adsorption capability of these adsorbents toward amanitin toxins. In the current work, we introduce a novel molecularly imprinted biomimetic adsorbent based on a ligand specificity determinant through surface imprinted strategy. Owing to the expensive price of the amanitin sources, we selected a typical common moiety of α, ß-amanitin as specificity determinant to synthesize a template necessary for the preparation of molecularly imprinted polymers (MIPs). Computer simulation was used to initially select acidic methacrylic acid (MAA) and basic 4-vinyl pyridine (4-VP) together as functional monomers. The experiments further demonstrated that the synergistic interaction of MAA and 4-VP played a primary role in the recognition of α, ß-amanitin by MIPs. By means of batch and packed-bed column experiment and the hemocompatibility evaluation, the resultant biomimetic adsorbent has been proved to be capable of selectively removing α, ß-amanitin and possess good hemocompatibility. This novel adsorbent has great potential to find application in human plasma purification.
[Mh] Termos MeSH primário: Alfa-Amanitina/sangue
Amanitinas/sangue
Biomimética/métodos
Impressão Molecular
[Mh] Termos MeSH secundário: Adsorção
Alfa-Amanitina/isolamento & purificação
Amanitinas/isolamento & purificação
Biomimética/instrumentação
Cromatografia Líquida de Alta Pressão
Seres Humanos
Microscopia Eletrônica de Varredura
Microesferas
Polímeros/química
Dióxido de Silício/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alpha-Amanitin); 0 (Amanitins); 0 (Polymers); 21150-22-1 (beta-amanitin); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170806
[Lr] Data última revisão:
170806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160711
[St] Status:MEDLINE


  5 / 1539 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27389675
[Au] Autor:Stankiewicz R; Lewandowski Z; Kotulski M; Patkowski W; Krawczyk M
[Ad] Endereço:Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
[Ti] Título:Effectiveness of Fractionated Plasma Separation and Absorption as a Treatment for Amanita Phalloides Poisoning.
[So] Source:Ann Transplant;21:428-32, 2016 Jul 08.
[Is] ISSN:2329-0358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Fractionated plasma separation and absorption (FPSA) is an extracorporeal liver support method that detoxifies accumulated toxins. There are limited data of its use in the treatment of Amanita phalloides intoxication. The objective of this study was to investigate whether FPSA before liver transplantation improves patients' short-term post liver transplantation survival in Amanita phalloides poisoning. MATERIAL AND METHODS The study population consisted of ten patients who had liver transplantation (LT) due to acute liver failure (ALF) caused by Amanita phalloides poisoning. Six patients were treated with FPSA before liver transplantation. All the patients who were started on FPSA were also placed on the liver transplantation list according to emergent liver transplantation criteria. RESULTS Patients treated with FPSA were in a more severe clinical condition presenting in higher mean MELD, total bilirubin, INR and ammonia along with more frequent hypoglycemia and hepatic encephalopathy grade 3/4. FPSA group had longer mean waiting time on the recipient list (3.5 vs. 1.25 days) but inferior thirty-day survival rate (16.5% vs. 100%). CONCLUSIONS When conservative medical modalities are ineffective, the only treatment for Amanita phalloides poisoning is a liver transplant. Although FPSA treated patients had inferior post-LT survival, FPSA was found to prolong the pre surgical waiting time for critically ill patients, consequently giving a chance of life-saving procedure.
[Mh] Termos MeSH primário: Falência Hepática Aguda/etiologia
Falência Hepática Aguda/terapia
Intoxicação Alimentar por Cogumelos/complicações
Intoxicação Alimentar por Cogumelos/terapia
Desintoxicação por Sorção/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Amanita
Amanitinas/sangue
Amanitinas/isolamento & purificação
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Falência Hepática Aguda/sangue
Transplante de Fígado
Masculino
Meia-Idade
Intoxicação Alimentar por Cogumelos/sangue
Estudos Retrospectivos
Fatores de Tempo
Listas de Espera
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amanitins); 54351-96-1 (phallotoxin); 58250-15-0 (amatoxin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE


  6 / 1539 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27124581
[Au] Autor:Mao Y; Tamura T; Yuki Y; Abe D; Tamada Y; Imoto S; Tanaka H; Homma H; Tagawa K; Miyano S; Okazawa H
[Ad] Endereço:Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
[Ti] Título:The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing.
[So] Source:Cell Death Dis;7:e2207, 2016 Apr 28.
[Is] ISSN:2041-4889
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, we identify signaling network of necrotic cell death induced by transcriptional repression (TRIAD) by α-amanitin (AMA), the selective RNA polymerase II inhibitor, as a model of neurodegenerative cell death. We performed genetic screen of a knockdown (KD) fly library by measuring the ratio of transformation from pupa to larva (PL ratio) under TRIAD, and selected the cell death-promoting genes. Systems biology analysis of the positive genes mapped on protein-protein interaction databases predicted the signaling network of TRIAD and the core pathway including heterogeneous nuclear ribonucleoproteins (hnRNPs) and huntingtin (Htt). RNA sequencing revealed that AMA impaired transcription and RNA splicing of Htt, which is known as an endoplasmic reticulum (ER)-stabilizing molecule. The impairment in RNA splicing and PL ratio was rescued by overexpresion of hnRNP that had been also affected by transcriptional repression. Fly genetics with suppressor or expresser of Htt and hnRNP worsened or ameliorated the decreased PL ratio by AMA, respectively. Collectively, these results suggested involvement of RNA splicing and a regulatory role of the hnRNP-Htt axis in the process of the transcriptional repression-induced necrosis.
[Mh] Termos MeSH primário: Apoptose
Proteínas de Drosophila/metabolismo
Ribonucleoproteínas Nucleares Heterogêneas/metabolismo
Proteína Huntingtina/metabolismo
[Mh] Termos MeSH secundário: Amanitinas/farmacologia
Animais
Apoptose/efeitos dos fármacos
Proteínas de Ciclo Celular/genética
Proteínas de Ciclo Celular/metabolismo
Células Cultivadas
Drosophila/crescimento & desenvolvimento
Drosophila/metabolismo
Proteínas de Drosophila/genética
Embrião de Mamíferos/citologia
Ribonucleoproteínas Nucleares Heterogêneas Grupo A-B/genética
Ribonucleoproteínas Nucleares Heterogêneas Grupo A-B/metabolismo
Ribonucleoproteínas Nucleares Heterogêneas/genética
Proteína Huntingtina/antagonistas & inibidores
Proteína Huntingtina/genética
Larva/metabolismo
Neurônios/citologia
Neurônios/metabolismo
Proteínas Serina-Treonina Quinases/genética
Proteínas Serina-Treonina Quinases/metabolismo
Proteínas Proto-Oncogênicas/genética
Proteínas Proto-Oncogênicas/metabolismo
Pupa/metabolismo
Processamento de RNA/efeitos dos fármacos
Ratos
Ratos Wistar
Ribonucleoproteínas/genética
Ribonucleoproteínas/metabolismo
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
Transcrição Genética/efeitos dos fármacos
Proteínas Contendo Repetições de beta-Transducina/genética
Proteínas Contendo Repetições de beta-Transducina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amanitins); 0 (Cell Cycle Proteins); 0 (Drosophila Proteins); 0 (Heterogeneous-Nuclear Ribonucleoprotein Group A-B); 0 (Heterogeneous-Nuclear Ribonucleoproteins); 0 (Hnrnpab protein, rat); 0 (Huntingtin Protein); 0 (Proto-Oncogene Proteins); 0 (Ribonucleoproteins); 0 (Transcription Factors); 0 (beta-Transducin Repeat-Containing Proteins); 0 (huntingtin protein, Drosophila); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.1 (polo-like kinase 1)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1038/cddis.2016.101


  7 / 1539 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27030094
[Au] Autor:Zaraf'iants GN
[Ad] Endereço:Saint-Petersburg State Medical University, Saint-Petersburg, Russia,199034; Institute of Toxicology, Russian Federal Medico-Biological Agency, Bureau of Forensic Medical Expertise, Saint-Petersburg, Russia, 192019.
[Ti] Título:[Forensic medical diagnostics of intoxication with certain poisonous mushrooms in the case of the lethal outcome in a hospital].
[So] Source:Sud Med Ekspert;59(1):22-28, 2016 Jan-Feb.
[Is] ISSN:0039-4521
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The present study was undertaken with a view to improving forensic medical diagnostics of intoxication with poisonous mushrooms in the cases of patients' death in a hospital. A total of 15 protocols of forensic medical examination of the corpses of the people who had died from acute poisoning were available for the analysis. The deathly toxins were amanitin and muscarine contained in various combinations in the death cap (Amanita phalloides) and the early false morels (Gyromitra esculenta and G. gigas). The main poisoning season in the former case was May and in the latter case August and September (93.4%). The mortality rate in the case of group intoxication (such cases accounted for 40% of the total) amounted to 28.6%. 40% of the deceased subjects consumed mushrooms together with alcohol. The poisoning caused the development of either phalloidin- or gyromitrin-intoxication syndromes (after consumption of Amanita phalloides and Gyromitra esculenta respectively). It is emphasized that the forensic medical experts must substantiate the diagnosis of poisoning with mushroom toxins based on the results of the chemical-toxicological and/or forensic chemical investigations. The relevant materials taken from the victim or the corpse should be dispatched for analysis not only within the first day but also on days 2-4 after intoxication. The mycological and genetic analysis must include the detection and identification of mushroom microparticles and spores in the smears from the oral cavity, vomiting matter, wash water, gastric and intestinal contents. In addition, the macro- and microscopic morphological signs, clinical data (major syndromes, results of laboratory studies, methods of treatment) should be taken into consideration as well as the time (season) of mushroom gathering, simultaneous poisoning in a group of people, and other pertinent information.
[Mh] Termos MeSH primário: Amanita/patogenicidade
Amanitinas/toxicidade
Intoxicação Alimentar por Cogumelos
Micotoxinas
[Mh] Termos MeSH secundário: Adulto
Cromatografia Líquida de Alta Pressão/métodos
Feminino
Seres Humanos
Masculino
Meia-Idade
Intoxicação Alimentar por Cogumelos/diagnóstico
Intoxicação Alimentar por Cogumelos/etiologia
Intoxicação Alimentar por Cogumelos/mortalidade
Intoxicação Alimentar por Cogumelos/fisiopatologia
Micotoxinas/análise
Micotoxinas/classificação
Prognóstico
Federação Russa/epidemiologia
Análise de Sobrevida
Fatores de Tempo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amanitins); 0 (Mycotoxins); 54351-96-1 (phallotoxin)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160401
[St] Status:MEDLINE
[do] DOI:10.17116/sudmed201659122-28


  8 / 1539 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26980450
[Au] Autor:Chan CK; Lam HC; Chiu SW; Tse ML; Lau FL
[Ad] Endereço:Hong Kong Poison Information Centre, United Christian Hospital, Kwun Tong, Hong Kong.
[Ti] Título:Mushroom poisoning in Hong Kong: a ten-year review.
[So] Source:Hong Kong Med J;22(2):124-30, 2016 Apr.
[Is] ISSN:1024-2708
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Mushroom poisoning is a cause of major mortality and morbidity all over the world. Although Hong Kong people consume a lot of mushrooms, there are only a few clinical studies and reviews of local mushroom poisoning. This study aimed to review the clinical characteristics, source, and outcome of mushroom poisoning incidences in Hong Kong. METHODS: This descriptive case series review was conducted by the Hong Kong Poison Information Centre and involved all cases of mushroom poisoning reported to the Centre from 1 July 2005 to 30 June 2015. RESULTS: Overall, 67 cases of mushroom poisoning were reported. Of these, 60 (90%) cases presented with gastrointestinal symptoms of vomiting, diarrhoea, and abdominal pain. Gastrointestinal symptoms were early onset (<6 hours post-ingestion) and not severe in 53 patients and all recovered after symptomatic treatment and a short duration of hospital care. Gastrointestinal symptoms, however, were of late onset (≥6 hours post-ingestion) in seven patients; these were life-threatening cases of amatoxin poisoning. In all cases, the poisonous mushroom had been picked from the wild. Three cases were imported from other countries, and four collected and consumed the amatoxin-containing mushrooms in Hong Kong. Of the seven cases of amatoxin poisoning, six were critically ill, of whom one died and two required liver transplantation. There was one confirmed case of hallucinogenic mushroom poisoning caused by Tylopilus nigerrimus after consumption of a commercial mushroom product. A number of poisoning incidences involved the consumption of wild-harvested dried porcini purchased in the market. CONCLUSION: Most cases of mushroom poisoning in Hong Kong presented with gastrointestinal symptoms and followed a benign course. Life-threatening cases of amatoxin poisoning are occasionally seen. Doctors should consider this diagnosis in patients who present with gastrointestinal symptoms that begin 6 hours or more after mushroom consumption.
[Mh] Termos MeSH primário: Amanitinas/envenenamento
Gastroenteropatias/etiologia
Intoxicação Alimentar por Cogumelos/epidemiologia
[Mh] Termos MeSH secundário: Dor Abdominal/epidemiologia
Dor Abdominal/etiologia
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Diarreia/epidemiologia
Diarreia/etiologia
Feminino
Gastroenteropatias/epidemiologia
Hong Kong/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Vômito/epidemiologia
Vômito/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amanitins); 58250-15-0 (amatoxin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE
[do] DOI:10.12809/hkmj154706


  9 / 1539 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26763394
[Au] Autor:Parnmen S; Sikaphan S; Leudang S; Boonpratuang T; Rangsiruji A; Naksuwankul K
[Ad] Endereço:Toxicology Center, National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Thailand.
[Ti] Título:Molecular identification of poisonous mushrooms using nuclear ITS region and peptide toxins: a retrospective study on fatal cases in Thailand.
[So] Source:J Toxicol Sci;41(1):65-76, 2016 Feb.
[Is] ISSN:1880-3989
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Cases of mushroom poisoning in Thailand have increased annually. During 2008 to 2014, the cases reported to the National Institute of Health included 57 deaths; at least 15 died after ingestion of amanitas, the most common lethal wild mushrooms inhabited. Hence, the aims of this study were to identify mushroom samples from nine clinically reported cases during the 7-year study period based on nuclear ITS sequence data and diagnose lethal peptide toxins using a reversed phase LC-MS method. Nucleotide similarity was identified using BLAST search of the NCBI database and the Barcode of Life Database (BOLD). Clade characterization was performed by maximum likelihood and Bayesian phylogenetic approaches. Based on BLAST and BOLD reference databases our results yielded high nucleotide similarities of poisonous mushroom samples to A. exitialis and A. fuliginea. Detailed phylogenetic analyses showed that all mushroom samples fall into their current classification. Detection of the peptide toxins revealed the presence of amatoxins and phallotoxins in A. exitialis and A. fuliginea. In addition, toxic α-amanitin was identified in a new provisional species, Amanita sp.1, with the highest toxin quantity. Molecular identification confirmed that the mushrooms ingested by the patients were members of the lethal amanitas in the sections Amanita and Phalloideae. In Thailand, the presence of A. exitialis was reported here for the first time and all three poisonous mushroom species provided new and informative data for clinical studies.
[Mh] Termos MeSH primário: Amanita/genética
Amanita/isolamento & purificação
Amanitinas/isolamento & purificação
Intoxicação Alimentar por Cogumelos/etiologia
[Mh] Termos MeSH secundário: Amanita/classificação
Amanitinas/genética
Cromatografia Líquida/métodos
Bases de Dados Genéticas
Seres Humanos
Espectrometria de Massas/métodos
Estudos Retrospectivos
Análise de Sequência de DNA
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amanitins); 54351-96-1 (phallotoxin); 58250-15-0 (amatoxin)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160114
[Lr] Data última revisão:
160114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160115
[St] Status:MEDLINE
[do] DOI:10.2131/jts.41.65


  10 / 1539 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26699189
[Au] Autor:Lacombe G; St-Onge M
[Ad] Endereço:Université Laval, Québec, Canada.
[Ti] Título:Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1: Silibinin in suspected amatoxin-containing mushroom poisoning.
[So] Source:Emerg Med J;33(1):76-7, 2016 Jan.
[Is] ISSN:1472-0213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A shortcut review was carried out to establish whether silibinin is better than conservative management at reducing liver transplantation and death after poisoning with amatoxin-containing mushrooms. Thirty-eight papers were found in Medline and 86 in EMBASE using the reported searches. Of these, five presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. It is concluded that the evidence is limited, but given the lack of alternative treatments in patients with suspected amatoxin-containing mushroom poisoning and the relatively few adverse effects, silibinin should be considered in some patients.
[Mh] Termos MeSH primário: Amanitinas/envenenamento
Antioxidantes/uso terapêutico
Intoxicação Alimentar por Cogumelos/tratamento farmacológico
Silimarina/uso terapêutico
[Mh] Termos MeSH secundário: Medicina de Emergência Baseada em Evidências
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amanitins); 0 (Antioxidants); 0 (Silymarin); 4RKY41TBTF (silybin); 58250-15-0 (amatoxin)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151224
[Lr] Data última revisão:
151224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151225
[St] Status:MEDLINE
[do] DOI:10.1136/emermed-2015-205558.1



página 1 de 154 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde