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  1 / 112 MEDLINE  
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[PMID]:28838073
[Au] Autor:Bradshaw CS; Jensen JS; Waites KB
[Ad] Endereço:Central Clinical School, Monash University.
[Ti] Título:New Horizons in Mycoplasma genitalium Treatment.
[So] Source:J Infect Dis;216(suppl_2):S412-S419, 2017 Jul 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mycoplasmagenitalium is an important sexually transmitted pathogen responsible for both male and female genital tract disease. Appreciation of its significance in human disease has been hampered by its slow growth in culture, difficulty in isolating it, and lack of commercial molecular-based tests for rapid detection. Comparatively few in vitro data on antimicrobial susceptibility are available due to the scarcity of clinical isolates and difficulty in performing susceptibility tests to determine minimum inhibitory concentrations for M. genitalium. Antimicrobial agents that inhibit protein synthesis such as macrolides, along with fluoroquinolones that inhibit DNA replication, have been the treatments of choice for M. genitalium infections. Even though international guidelines recommend azithromycin as first-line treatment, rapid spread of macrolide resistance as well as emergence of quinolone resistance has occurred. Increasing rates of treatment failure have resulted in an urgent need for new therapies and renewed interest in other classes such as aminocyclitols, phenicols, and streptogramins as treatment alternatives. Limited data for new investigational antimicrobials such as the ketolide solithromycin suggest that this drug may eventually prove useful in management of some resistant M. genitalium infections, although it is not likely to achieve cure rates >80% in macrolide-resistant strains, in a similar range as recently reported for pristinamycin. However, agents with completely new targets and/or mechanisms that would be less likely to show cross-resistance with currently available drugs may hold the greatest promise. Lefamulin, a pleuromutilin, and new nonquinolone topoisomerase inhibitors are attractive possibilities that require further investigation.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Descoberta de Drogas/classificação
Infecções por Mycoplasma/diagnóstico
Infecções por Mycoplasma/tratamento farmacológico
[Mh] Termos MeSH secundário: Azitromicina/uso terapêutico
Farmacorresistência Bacteriana
Feminino
Fluoroquinolonas/uso terapêutico
Seres Humanos
Masculino
Testes de Sensibilidade Microbiana
Mycoplasma genitalium
Quinolinas/uso terapêutico
Espectinomicina/uso terapêutico
Estreptograminas/uso terapêutico
Tetraciclinas/uso terapêutico
Tianfenicol/uso terapêutico
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); 0 (Quinolines); 0 (Streptogramins); 0 (Tetracyclines); 83905-01-5 (Azithromycin); 93AKI1U6QF (Spectinomycin); E66400VT9R (quinoline); FLQ7571NPM (Thiamphenicol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix132


  2 / 112 MEDLINE  
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[PMID]:28664720
[Au] Autor:Marosevic D; Kaevska M; Jaglic Z
[Ad] Endereço:Bavarian Health Food Safety Authority, 85764 Oberschleißheim, Germany. kaevska@vri.cz.
[Ti] Título:Resistance to the tetracyclines and macrolide-lincosamide-streptogramin group of antibiotics and its genetic linkage - a review.
[So] Source:Ann Agric Environ Med;24(2):338-344, 2017 Jun 12.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:An excessive use of antimicrobial agents poses a risk for the selection of resistant bacteria. Of particular interest are antibiotics that have large consumption rates in both veterinary and human medicine, such as the tetracyclines and macrolide-lincosamide-streptogramin (MLS) group of antibiotics. A high load of these agents increases the risk of transmission of resistant bacteria and/or resistance determinants to humans, leading to a subsequent therapeutic failure. An increasing incidence of bacteria resistant to both tetracyclines and MLS antibiotics has been recently observed. This review summarizes the current knowledge on different tetracycline and MLS resistance genes that can be linked together on transposable elements.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Bactérias/genética
Infecções Bacterianas/microbiologia
Farmacorresistência Bacteriana
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Estreptograminas/farmacologia
Tetraciclinas/farmacologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/metabolismo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins); 0 (Tetracyclines)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE


  3 / 112 MEDLINE  
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[PMID]:28505372
[Au] Autor:Osterman IA; Khabibullina NF; Komarova ES; Kasatsky P; Kartsev VG; Bogdanov AA; Dontsova OA; Konevega AL; Sergiev PV; Polikanov YS
[Ad] Endereço:Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow 119992, Russia.
[Ti] Título:Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.
[So] Source:Nucleic Acids Res;45(12):7507-7514, 2017 Jul 07.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The emergence of multi-drug resistant bacteria is limiting the effectiveness of commonly used antibiotics, which spurs a renewed interest in revisiting older and poorly studied drugs. Streptogramins A is a class of protein synthesis inhibitors that target the peptidyl transferase center (PTC) on the large subunit of the ribosome. In this work, we have revealed the mode of action of the PTC inhibitor madumycin II, an alanine-containing streptogramin A antibiotic, in the context of a functional 70S ribosome containing tRNA substrates. Madumycin II inhibits the ribosome prior to the first cycle of peptide bond formation. It allows binding of the tRNAs to the ribosomal A and P sites, but prevents correct positioning of their CCA-ends into the PTC thus making peptide bond formation impossible. We also revealed a previously unseen drug-induced rearrangement of nucleotides U2506 and U2585 of the 23S rRNA resulting in the formation of the U2506•G2583 wobble pair that was attributed to a catalytically inactive state of the PTC. The structural and biochemical data reported here expand our knowledge on the fundamental mechanisms by which peptidyl transferase inhibitors modulate the catalytic activity of the ribosome.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Proteínas de Bactérias/antagonistas & inibidores
Peptidil Transferases/antagonistas & inibidores
Inibidores da Síntese de Proteínas/farmacologia
RNA de Transferência/antagonistas & inibidores
Ribossomos/efeitos dos fármacos
Estreptograminas/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Proteínas de Bactérias/química
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Sítios de Ligação
Domínio Catalítico
Escherichia coli/efeitos dos fármacos
Escherichia coli/enzimologia
Escherichia coli/genética
Modelos Moleculares
Conformação de Ácido Nucleico
Peptidil Transferases/química
Peptidil Transferases/genética
Peptidil Transferases/metabolismo
Biossíntese de Proteínas/efeitos dos fármacos
Inibidores da Síntese de Proteínas/química
RNA Ribossômico 23S/antagonistas & inibidores
RNA Ribossômico 23S/química
RNA Ribossômico 23S/metabolismo
RNA de Transferência/química
RNA de Transferência/metabolismo
Ribossomos/genética
Ribossomos/metabolismo
Estreptograminas/química
Thermus thermophilus/efeitos dos fármacos
Thermus thermophilus/enzimologia
Thermus thermophilus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Protein Synthesis Inhibitors); 0 (RNA, Ribosomal, 23S); 0 (Streptogramins); 0 (madumycin II); 9014-25-9 (RNA, Transfer); EC 2.3.2.12 (Peptidyl Transferases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkx413


  4 / 112 MEDLINE  
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[PMID]:27799208
[Au] Autor:Strauss C; Hu Y; Coates A; Perreten V
[Ad] Endereço:Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
[Ti] Título:A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.
[So] Source:Antimicrob Agents Chemother;61(1), 2017 Jan.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel erm(44) gene variant, erm(44) , has been identified by whole-genome sequencing in a Staphylococcus saprophyticus isolate from the skin of a healthy person. It has the particularity to confer resistance to macrolides and lincosamides but not to streptogramin B when expressed in S. aureus The erm(44) gene resides on a 19,400-bp genomic island which contains phage-associated proteins and is integrated into the chromosome of S. saprophyticus.
[Mh] Termos MeSH primário: Lincosamidas/farmacologia
Macrolídeos/farmacologia
Staphylococcus aureus/efeitos dos fármacos
Estreptograminas/farmacologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Farmacorresistência Bacteriana Múltipla/genética
Ilhas Genômicas/genética
Seres Humanos
Testes de Sensibilidade Microbiana
Staphylococcus/efeitos dos fármacos
Staphylococcus/metabolismo
Staphylococcus aureus/genética
Estreptogramina B/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins); 3131-03-1 (Streptogramin B)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE


  5 / 112 MEDLINE  
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[PMID]:27318609
[Au] Autor:Kraushaar B; Ballhausen B; Leeser D; Tenhagen BA; Käsbohrer A; Fetsch A
[Ad] Endereço:Federal Institute for Risk Assessment, Department Biological Safety, Berlin, Germany.
[Ti] Título:Antimicrobial resistances and virulence markers in Methicillin-resistant Staphylococcus aureus from broiler and turkey: A molecular view from farm to fork.
[So] Source:Vet Microbiol;200:25-32, 2017 Feb.
[Is] ISSN:1873-2542
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Little is known about the characteristics of MRSA occurring along the broiler and turkey production chains. The aim of this study was to characterise and compare MRSA of turkey and broiler origin sampled on different production levels using a DNA microarray and antimicrobial susceptibility testing. Main differences could be observed in the prevalence of the resistance genes erm(C), aacA-aphD and tet(K) and the number of non-wild type strains with minimum inhibitory concentration values (MICs) above the epidemiological cut-off values (ECOFFs) for gentamicin and kanamycin. Overall, MRSA with non-wild type phenotype for the macrolide-lincosamide-streptogramin group, tetracycline, and trimethoprim were found in more than 70% of poultry isolates. Non-wild type isolates carrying the qacC gene conferring resistance to quaternary ammonium compound disinfectants were found at all production stages in similar frequencies. Regarding the presence of enterotoxin genes in poultry-derived MRSA the enterotoxin gene cluster (egc) was only found in Non-CC (clonal complex) 398 strains. Three CC398 strains harboured the genes sed (from turkey at slaughter and broiler meat) and sea-N315 (from a chicken carcass). One Non-CC398 strain isolated from turkey meat was found positive for the seb gene and also enterotoxin production. Similarity analysis based on selected resistance and virulence markers revealed a high clonality among Non-CC398 isolates. Isolates of the same clonal complex clustered together according to their common virulence and resistance profiles. Strains of CC9 were grouped in two subclusters due to different resistance genes. Our results underline, that there are other poultry associated clones of MRSA (mainly CC9 and CC5) besides the predominant CC398 which are similar in both poultry species.
[Mh] Termos MeSH primário: Galinhas/microbiologia
Farmacorresistência Bacteriana
Staphylococcus aureus Resistente à Meticilina
Doenças das Aves Domésticas/microbiologia
Infecções Estafilocócicas/veterinária
Perus/microbiologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Enterotoxinas/genética
Fazendas
Alemanha
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Meticilina/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/patogenicidade
Testes de Sensibilidade Microbiana
Fenótipo
Infecções Estafilocócicas/microbiologia
Estreptograminas/farmacologia
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Enterotoxins); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160620
[St] Status:MEDLINE


  6 / 112 MEDLINE  
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[PMID]:27578091
[Au] Autor:Wang M; Sun J; Zhong W; Xiong W; Zeng Z; Sun Y
[Ad] Endereço:National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, National Risk Assessment Laboratory For Antimicrobial Resistance Of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Wushan Road, Guangzhou, China.
[Ti] Título:Presence and distribution of Macrolides-Lincosamide-Streptogramin resistance genes and potential indicator ARGs in the university ponds in Guangzhou, China.
[So] Source:Environ Sci Pollut Res Int;23(22):22937-22946, 2016 Nov.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study aimed to determine the occurrence, abundance, and variation of seven Macrolides-Lincosamide-Streptogramin (MLS) resistance genes (ereB, ermA, ermB, ermF, mefA, vatB, mphA) and six potential indicator ARGs (tet (B), sul1, qnrS, fexA, IntI1, ermB) from three ponds at university by quantitative PCR and assess the impacts on the surroundings. Solid samples (fish feces, soil and sediment) and water samples were tested. All the genes were found at low levels in soil samples. For the MLS resistance genes, only two MLS genes (ermB, ermF) were detected in all samples and significant correlations between ermB and Σ MLS (R = 0.91 in solid samples; R = 0.86 in water samples, p < 0.01) were found. For the potential indicators, intl1 and sul1 were present at high levels in the three different ponds while the other genes showed varying levels. These findings show that the ermB gene can probably be served as an indicator to evaluate the overall level of MLS resistance genes. The fairly low abundance of all the tested resistance genes in soil samples and the moderate levels in other samples suggests that the university ponds kept a good state and did not have a significant impact on their surroundings.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Tanques/microbiologia
Estreptograminas/farmacologia
[Mh] Termos MeSH secundário: China
Regulação Bacteriana da Expressão Gênica
Universidades
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160901
[St] Status:MEDLINE


  7 / 112 MEDLINE  
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[PMID]:27531625
[Au] Autor:Ehrmann E; Jolivet-Gougeon A; Bonnaure-Mallet M; Fosse T
[Ad] Endereço:Pôle odontologie, CHU de Nice, Nice, France; Faculté d'odontologie, Université de Nice-Sophia-Antipolis, Nice, France.
[Ti] Título:Multidrug-resistant oral Capnocytophaga gingivalis responsible for an acute exacerbation of chronic obstructive pulmonary disease: Case report and literature review.
[So] Source:Anaerobe;42:50-54, 2016 Dec.
[Is] ISSN:1095-8274
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Capnocytophaga genus was recently known to highly contribute to the beta-lactam (BL) and macrolide-lincosamide-streptogramin (MLS) resistance gene reservoir in the oral microbiota (BL: bla and bla ; MLS: erm(F) and erm(C)). But fluoroquinolone (FQ) resistance remains uncommon in literature, without available data on resistance mechanisms. CASE REPORT: For the first time, a case of acute exacerbation of chronic obstructive pulmonary disease (COPD) was described in a 78-year-old immunocompetent patient due to a multidrug-resistant Capnocytophaga gingivalis isolate with significant microbiological finding. C.gingivalis acquired resistance to third generation cephalosporins (bla gene), MLS (erm(F) gene), and fluoroquinolones. Genetics of the resistance, unknown as regards fluoroquinolone, was investigated and a substitution in QRDR of GyrA was described (Gly80Asn substitution) for the first time in the Capnocytophaga genus. LITERATURE REVIEW: A comprehensive literature review of Capnocytophaga spp. extra-oral infection was conducted. Including the present report, on 43 cases, 7 isolates were BL-resistant (17%), 4 isolates were MLS-resistant (9.5%) and 4 isolates were FQ-resistant (9.5%). The studied clinical isolate of C.gingivalis was the only one to combine resistance to the three groups of antibiotics BL, MLS and FQ. Four cases of Capnocytophaga lung infection were reported, including three infections involving C. gingivalis (two FQ resistant) and one involving C. sputigena. CONCLUSION: This multidrug-resistant C. gingivalis isolate illustrated the role of oral flora as a reservoir of antibiotic resistance and its contribution to the limitation of effective antibiotics in severe respiratory infections.
[Mh] Termos MeSH primário: Capnocytophaga/genética
DNA Girase/genética
Farmacorresistência Bacteriana Múltipla/genética
Infecções por Bactérias Gram-Negativas/diagnóstico
Doença Pulmonar Obstrutiva Crônica/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Antibacterianos/farmacologia
Capnocytophaga/efeitos dos fármacos
Capnocytophaga/isolamento & purificação
Capnocytophaga/patogenicidade
Cefalosporinas/farmacologia
Fluoroquinolonas/farmacologia
Expressão Gênica
Infecções por Bactérias Gram-Negativas/microbiologia
Infecções por Bactérias Gram-Negativas/patologia
Seres Humanos
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Masculino
Mutação
Doença Pulmonar Obstrutiva Crônica/microbiologia
Doença Pulmonar Obstrutiva Crônica/patologia
Estreptograminas/farmacologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cephalosporins); 0 (Fluoroquinolones); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins); EC 5.99.1.3 (DNA Gyrase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  8 / 112 MEDLINE  
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[PMID]:27480862
[Au] Autor:Wan TW; Hung WC; Tsai JC; Lin YT; Lee H; Hsueh PR; Lee TF; Teng LJ
[Ad] Endereço:Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
[Ti] Título:Novel Structure of Enterococcus faecium-Originated ermB-Positive Tn1546-Like Element in Staphylococcus aureus.
[So] Source:Antimicrob Agents Chemother;60(10):6108-14, 2016 Oct.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We determined the resistance determinants in 274 erythromycin-resistant methicillin-susceptible Staphylococcus aureus (MSSA) isolates during a 13-year period, 2000 to 2012. The resistance phenotypes, inducible macrolide-lincosamide-streptogramin (iMLS), constitutive MLS (cMLS), and macrolide-streptogramin (MS) resistance phenotypes, were examined by a double-disk diffusion D test. The ermB gene was more frequent (35%; 97/274) than ermC (27%; 75/274) or ermA (21%; 58/274). All 97 ermB-positive isolates harbored Tn551 and IS1216V The majority (89/97) of ermB-positive isolates displayed the cMLS phenotype and carried mobile element structure (MES)-like structures, which has been previously reported in sequence type 59 (ST59) methicillin-resistant S. aureus (MRSA). The remaining 8 ermB-carrying isolates, belonging to ST7 (n = 4), ST5 (n = 3), and ST59 (n = 1), were sasK intact and did not carry MES-like structures. Unlike a MES-like structure that was located on the chromosome, the ermB elements on sasK-intact isolates were located on plasmids by S1 nuclease pulsed-field gel electrophoresis (PFGE) analysis and conjugation tests. Sequence data for the ermB-containing region (14,566 bp) from ST59 NTUH_3874 revealed that the best match was a Tn1546-like element in plasmid pMCCL2 DNA (GenBank accession number AP009486) of Macrococcus caseolyticus Tn1546 is recognized as an enterococcal transposon and was known from the vancomycin resistance gene cluster in vancomycin-resistant Enterococcus (VRE). So far, acquisitions of Tn1546 in S. aureus have occurred in clonal complex 5 (CC5) MRSA, but not in MSSA. This is the first report that MSSA harbors an Enterococcus faecium-originated ermB-positive Tn1546-like element located on a plasmid.
[Mh] Termos MeSH primário: Elementos de DNA Transponíveis
Farmacorresistência Bacteriana Múltipla/genética
Enterococcus faecium/genética
Transferência Genética Horizontal
Staphylococcus aureus Resistente à Meticilina/genética
Plasmídeos/metabolismo
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Cromossomos Bacterianos/química
Conjugação Genética
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Eletroforese em Gel de Campo Pulsado
Enterococcus faecium/efeitos dos fármacos
Enterococcus faecium/metabolismo
Enterococcus faecium/patogenicidade
Expressão Gênica
Isoenzimas/genética
Isoenzimas/metabolismo
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/metabolismo
Staphylococcus aureus Resistente à Meticilina/patogenicidade
Metiltransferases/genética
Metiltransferases/metabolismo
Fenótipo
Plasmídeos/química
Análise de Sequência de DNA
Estreptograminas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (DNA Transposable Elements); 0 (Isoenzymes); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins); EC 2.1.1.- (Methyltransferases); EC 2.1.1.184 (ErmA protein, Bacteria); EC 2.1.1.230 (rRNA (adenosine-O-2'-)methyltransferase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.01096-16


  9 / 112 MEDLINE  
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[PMID]:26978225
[Au] Autor:Lenart-Boron A; Wolny-Koladka K; Stec J; Kasprowic A
[Ad] Endereço:1 Department of Microbiology, University of Agriculture , Kraków, Poland .
[Ti] Título:Phenotypic and Molecular Antibiotic Resistance Determination of Airborne Coagulase Negative Staphylococcus spp. Strains from Healthcare Facilities in Southern Poland.
[So] Source:Microb Drug Resist;22(7):515-522, 2016 Oct.
[Is] ISSN:1931-8448
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study assessed the antimicrobial resistance of airborne Staphylococcus spp. strains isolated from healthcare facilities in southern Poland. A total of 55 isolates, belonging to 10 coagulase-negative staphylococci (CoNS) species, isolated from 10 healthcare facilities (including hospitals and outpatient units) were included in the analysis. The most frequently identified species were Staphylococcus saprophyticus and Staphylococcus warneri, which belong to normal human skin flora, but can also be the cause of common and even severe nosocomial infections. Disk diffusion tests showed that the bacterial strains were most frequently resistant to erythromycin and tetracycline and only 18% of strains were susceptible to all tested antimicrobials. Polymerase chain reaction amplification of specific gene regions was used to determine the presence of the Macrolide-Lincosamide-Streptogramin resistance mechanisms in CoNS. The molecular analysis, conducted using specific primer pairs, identified the msrA1 gene, encoding active efflux pumps in bacterial cells, as the most frequent resistance gene. As many as seven antibiotic resistance genes were found in one isolate, whereas the most common number of resistance genes per isolate was five (n = 17). It may be concluded that drug resistance was widely spread among the tested strains, but the resulting antimicrobial resistance profile indicates that in the case of infection, the use of antibiotics from the basic antibiogram group will be effective in therapy. However, before administering treatment, determination of the specific antimicrobial resistance should be conducted, particularly in the case of hospitalized patients.
[Mh] Termos MeSH primário: Microbiologia do Ar
Antibacterianos/farmacologia
Farmacorresistência Bacteriana Múltipla/genética
Genes Bacterianos
Genes MDR
Staphylococcus saprophyticus/genética
Staphylococcus/genética
[Mh] Termos MeSH secundário: Instituições de Assistência Ambulatorial
Coagulase
Eritromicina/farmacologia
Genótipo
Hospitais
Seres Humanos
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Testes de Sensibilidade Microbiana
Fenótipo
Staphylococcus/classificação
Staphylococcus/efeitos dos fármacos
Staphylococcus/isolamento & purificação
Staphylococcus saprophyticus/classificação
Staphylococcus saprophyticus/efeitos dos fármacos
Staphylococcus saprophyticus/isolamento & purificação
Estreptograminas/farmacologia
Tetraciclina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coagulase); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins); 63937KV33D (Erythromycin); F8VB5M810T (Tetracycline)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170419
[Lr] Data última revisão:
170419
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160316
[St] Status:MEDLINE


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[PMID]:26253583
[Au] Autor:Szczuka E; Makowska N; Bosacka K; Slotwinska A; Kaznowski A
[Ad] Endereço:Department of Microbiology, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University, ul. Umultowska 89, 61-614, Poznan, Poland. ewasz@amu.edu.pl.
[Ti] Título:Molecular basis of resistance to macrolides, lincosamides and streptogramins in Staphylococcus hominis strains isolated from clinical specimens.
[So] Source:Folia Microbiol (Praha);61(2):143-7, 2016 Mar.
[Is] ISSN:1874-9356
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Coagulase-negative staphylococci (CoNS) are the most frequently isolated bacteria from the blood and the predominant cause of nosocomial infections. Macrolides, lincosamides and streptogramin B (MLSB) antibiotics, especially erythromycin and clindamycin, are important therapeutic agents in the treatment of methicillin-resistant staphylococci infections. Among CoNS, Staphylococcus hominis represents the third most common organism. In spite of its clinical significance, very little is known about its mechanisms of resistance to antibiotics, especially MLSB. Fifty-five S. hominis isolates from the blood and the surgical wounds of hospitalized patients were studied. The erm(C) gene was predominant in erythromycin-resistant S. hominis isolates. The methylase genes, erm(A) and erm(B), were present in 15 and 25% of clinical isolates, respectively. A combination of various erythromycin resistance methylase (erm) genes was detected in 15% S. hominis isolates. The efflux gene msr(A) was detected in 18% of isolates, alone in four isolates, and in different combinations in a further six. The lnu(A) gene, responsible for enzymatic inactivation of lincosamides was carried by 31% of the isolates. No erythromycin resistance that could not be attributed to the genes erm(A), erm(B), erm(C) and msr(A) was detected. In S. hominis, 75 and 84%, respectively, were erythromycin resistant and clindamycin susceptible. Among erythromycin-resistant S. hominis isolates, 68% of these strains showed the inducible MLSB phenotype. Four isolates harbouring the msr(A) genes alone displayed the MSB phenotype. These studies indicated that resistance to MLSB in S. hominis is mostly based on the ribosomal target modification mechanism mediated by erm genes, mainly the erm(C), and enzymatic drug inactivation mediated by lnu(A).
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Infecções Estafilocócicas/microbiologia
Staphylococcus hominis/efeitos dos fármacos
Estreptograminas/farmacologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Farmacorresistência Bacteriana Múltipla
Seres Humanos
Metiltransferases/genética
Metiltransferases/metabolismo
Testes de Sensibilidade Microbiana
Staphylococcus hominis/classificação
Staphylococcus hominis/enzimologia
Staphylococcus hominis/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins); EC 2.1.1.- (Methyltransferases); EC 2.1.1.184 (ErmA protein, Bacteria)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150809
[St] Status:MEDLINE
[do] DOI:10.1007/s12223-015-0419-6



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