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[PMID]:28270110
[Au] Autor:Beukers AG; Zaheer R; Goji N; Amoako KK; Chaves AV; Ward MP; McAllister TA
[Ad] Endereço:Faculty of Veterinary Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.
[Ti] Título:Comparative genomics of Enterococcus spp. isolated from bovine feces.
[So] Source:BMC Microbiol;17(1):52, 2017 Mar 08.
[Is] ISSN:1471-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Enterococcus is ubiquitous in nature and is a commensal of both the bovine and human gastrointestinal (GI) tract. It is also associated with clinical infections in humans. Subtherapeutic administration of antibiotics to cattle selects for antibiotic resistant enterococci in the bovine GI tract. Antibiotic resistance genes (ARGs) may be present in enterococci following antibiotic use in cattle. If located on mobile genetic elements (MGEs) their dissemination between Enterococcus species and to pathogenic bacteria may be promoted, reducing the efficacy of antibiotics. RESULTS: We present a comparative genomic analysis of twenty-one Enterococcus spp. isolated from bovine feces including Enterococcus hirae (n = 10), Enterococcus faecium (n = 3), Enterococcus villorum (n = 2), Enterococcus casseliflavus (n = 2), Enterococcus faecalis (n = 1), Enterococcus durans (n = 1), Enterococcus gallinarum (n = 1) and Enterococcus thailandicus (n = 1). The analysis revealed E. faecium and E. faecalis from bovine feces share features with human clinical isolates, including virulence factors. The Tn917 transposon conferring macrolide-lincosamide-streptogramin B resistance was identified in both E. faecium and E. hirae, suggesting dissemination of ARGs on MGEs may occur in the bovine GI tract. An E. faecium isolate was also identified with two integrative conjugative elements (ICEs) belonging to the Tn916 family of ICE, Tn916 and Tn5801, both conferring tetracycline resistance. CONCLUSIONS: This study confirms the presence of enterococci in the bovine GI tract possessing ARGs on MGEs, but the predominant species in cattle, E. hirae is not commonly associated with infections in humans. Analysis using additional complete genomes of E. faecium from the NCBI database demonstrated differential clustering of commensal and clinical isolates, suggesting that these strains may be specifically adapted to their respective environments.
[Mh] Termos MeSH primário: Bovinos/microbiologia
Enterococcus/classificação
Enterococcus/genética
Enterococcus/isolamento & purificação
Fezes/microbiologia
Genoma Bacteriano/genética
Genômica
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Bacteriófagos
Sistemas CRISPR-Cas
Doenças dos Bovinos/microbiologia
Análise por Conglomerados
Elementos de DNA Transponíveis/genética
DNA Bacteriano/isolamento & purificação
Farmacorresistência Bacteriana Múltipla/genética
Enterococcus/efeitos dos fármacos
Enterococcus faecalis/efeitos dos fármacos
Enterococcus faecalis/genética
Enterococcus faecalis/isolamento & purificação
Enterococcus faecalis/patogenicidade
Enterococcus faecium/efeitos dos fármacos
Enterococcus faecium/genética
Enterococcus faecium/isolamento & purificação
Enterococcus faecium/patogenicidade
Enterococcus hirae/efeitos dos fármacos
Enterococcus hirae/genética
Enterococcus hirae/isolamento & purificação
Enterococcus hirae/patogenicidade
Microbioma Gastrointestinal
Seres Humanos
Sequências Repetitivas Dispersas/genética
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Testes de Sensibilidade Microbiana
Tipagem de Sequências Multilocus/métodos
Filogenia
Polimorfismo de Nucleotídeo Único
Estreptogramina B/farmacologia
Resistência a Tetraciclina/genética
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA Transposable Elements); 0 (DNA, Bacterial); 0 (Lincosamides); 0 (Macrolides); 0 (Virulence Factors); 3131-03-1 (Streptogramin B)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1186/s12866-017-0962-1


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[PMID]:28231812
[Au] Autor:Foster-Nyarko E; Kwambana B; Ceesay F; Jawneh K; Darboe S; Mulwa SN; Ceesay B; Secka OO; Adetifa I; Antonio M
[Ad] Endereço:Vaccines and Immunity Theme, Medical Research Council Unit The Gambia, Banjul, The Gambia.
[Ti] Título:Incidence of macrolide-lincosamide-streptogramin B resistance amongst beta-haemolytic streptococci in The Gambia.
[So] Source:BMC Res Notes;10(1):106, 2017 Feb 23.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In West Africa, penicillin, macrolide and lincosamide resistance among beta-haemolytic streptococci (BHS) isolates has rarely been described. However, such data are critical to detect and track the emergence of antibiotic resistance. METHODS: Beta-haemolytic streptococci were cultured from clinical specimens from patients attending the clinic at the Medical Research Council Unit The Gambia (n = 217) and kept at -70 °C. Of these, 186 were revived and tested for penicillin susceptibility by disc diffusion and E-test methods, and the D-test for determination of constitutive and inducible macrolide-lincosamide (MLS ) resistance phenotypes. RESULTS: The majority of BHS isolates from infections were group A streptococci (GAS) (126/186, 67.7%). Of these, 16% were from invasive disease (30/186). Other BHS isolated included lancefield groups B (19, 10.2%); C (9/186, 4.8%), D (3/186, 1.6%), F (5/186, 2.7%), G (16/186, 8.6%) and non-typeable (8/186, 4.3%). Prevalence of BHS isolated from blood cultures ranges from 0% (2005) to 0.5% (2010). Most (85, 45.7%) of the isolates were from wound infections. Of the 186 BHS isolates, none was resistant to penicillin and 14 (6.1%) were resistant to erythromycin. Of these, 8 (4.3%) demonstrated constitutive MLS resistance, and 5 (2.7%) were inducible MLS resistant. All the inducible MLS isolates were GAS, and majority of the constitutive MLS isolates (6/8, 75.0%) were non-GAS. CONCLUSIONS: Beta-haemolytic streptococci, predominantly GAS are associated with a wide range of infections in The Gambia. It is reassuring that macrolide and lincosamide resistance is relatively low. However, monitoring of MLS resistance is necessary with the global spread of resistant BHS strains.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana Múltipla
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Streptococcus pyogenes/efeitos dos fármacos
Estreptogramina B/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Gâmbia/epidemiologia
Hemólise
Seres Humanos
Incidência
Lactente
Recém-Nascido
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Infecções Estreptocócicas/epidemiologia
Infecções Estreptocócicas/microbiologia
Infecções Estreptocócicas/patologia
Streptococcus pyogenes/crescimento & desenvolvimento
Streptococcus pyogenes/isolamento & purificação
Streptococcus pyogenes/patogenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Lincosamides); 0 (Macrolides); 3131-03-1 (Streptogramin B)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2427-x


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[PMID]:27799208
[Au] Autor:Strauss C; Hu Y; Coates A; Perreten V
[Ad] Endereço:Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland.
[Ti] Título:A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.
[So] Source:Antimicrob Agents Chemother;61(1), 2017 Jan.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel erm(44) gene variant, erm(44) , has been identified by whole-genome sequencing in a Staphylococcus saprophyticus isolate from the skin of a healthy person. It has the particularity to confer resistance to macrolides and lincosamides but not to streptogramin B when expressed in S. aureus The erm(44) gene resides on a 19,400-bp genomic island which contains phage-associated proteins and is integrated into the chromosome of S. saprophyticus.
[Mh] Termos MeSH primário: Lincosamidas/farmacologia
Macrolídeos/farmacologia
Staphylococcus aureus/efeitos dos fármacos
Estreptograminas/farmacologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Farmacorresistência Bacteriana Múltipla/genética
Ilhas Genômicas/genética
Seres Humanos
Testes de Sensibilidade Microbiana
Staphylococcus/efeitos dos fármacos
Staphylococcus/metabolismo
Staphylococcus aureus/genética
Estreptogramina B/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins); 3131-03-1 (Streptogramin B)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE


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[PMID]:27494920
[Au] Autor:Guérin F; Isnard C; Bucquet F; Fines-Guyon M; Giard JC; Burrus V; Cattoir V
[Ad] Endereço:Université de Caen Normandie, EA4655 U2RM (équipe 'Antibio-résistance'), Caen, France.
[Ti] Título:Novel chromosome-encoded erm(47) determinant responsible for constitutive MLSB resistance in Helcococcus kunzii.
[So] Source:J Antimicrob Chemother;71(11):3046-3049, 2016 Nov.
[Is] ISSN:1460-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of the study was to identify the determinant responsible for erythromycin resistance in Helcococcus kunzii clinical isolate UCN99 and to characterize the genetic support and environment of this novel gene. METHODS: MICs were determined using the broth microdilution method according to EUCAST guidelines. The entire genome sequence of H. kunzii UCN99 was determined using a 454/Roche GS Junior sequencer. The fragment encompassing the new resistance gene and its own promoter was cloned into the pAT29 shuttle vector and the recombinant plasmid pAT29Ωerm(47) was expressed in both Staphylococcus aureus and Streptococcus agalactiae. The transcription start site (TSS) was experimentally determined by 5' RACE-PCR. RESULTS: UCN99 exhibited a constitutive macrolide/lincosamide/streptogramin B (MLS ) resistance phenotype, suggesting the presence of an Erm protein. WGS allowed the identification of a novel gene, named erm(47), encoding a protein sharing 44%-48% amino acid identity with known Erm methylases. In both S. aureus and S. agalactiae, the introduction of pAT29Ωerm(47) conferred a significant increase (≥16-fold) in MICs of all macrolides and lincosamides tested, as well as a 4-fold increase in MICs of quinupristin (streptogramin B), confirming the MLS resistance. The TSS identification revealed the presence of a short leader peptide, potentially implicated in a translational attenuation mechanism. It was also demonstrated that erm(47) was harboured by a 81 kb genomic island integrated into a chromosomal gene. CONCLUSIONS: This is the first description of a novel MLS resistance determinant, named erm(47). The prevalence of this gene among Gram-positive cocci must be further investigated to determine its clinical significance.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana
Firmicutes/efeitos dos fármacos
Genes Bacterianos
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Estreptogramina B/farmacologia
[Mh] Termos MeSH secundário: Cromossomos Bacterianos
Clonagem Molecular
DNA Bacteriano/química
DNA Bacteriano/genética
Firmicutes/genética
Expressão Gênica
Testes de Sensibilidade Microbiana
Regiões Promotoras Genéticas
Análise de Sequência de DNA
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/genética
Streptococcus agalactiae/efeitos dos fármacos
Streptococcus agalactiae/genética
Sítio de Iniciação de Transcrição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 0 (Lincosamides); 0 (Macrolides); 3131-03-1 (Streptogramin B)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE


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[PMID]:27353268
[Au] Autor:Cipcic Paljetak H; Verbanac D; Padovan J; Dominis-Kramaric M; Kelneric Z; Peric M; Banjanac M; Ergovic G; Simon N; Broskey J; Holmes DJ; Erakovic Haber V
[Ad] Endereço:GlaxoSmithKline Research Centre Zagreb, Zagreb, Croatia hana.paljetak@mef.hr.
[Ti] Título:Macrolones Are a Novel Class of Macrolide Antibiotics Active against Key Resistant Respiratory Pathogens In Vitro and In Vivo.
[So] Source:Antimicrob Agents Chemother;60(9):5337-48, 2016 Sep.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As we face an alarming increase in bacterial resistance to current antibacterial chemotherapeutics, expanding the available therapeutic arsenal in the fight against resistant bacterial pathogens causing respiratory tract infections is of high importance. The antibacterial potency of macrolones, a novel class of macrolide antibiotics, against key respiratory pathogens was evaluated in vitro and in vivo MIC values against Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, and Haemophilus influenzae strains sensitive to macrolide antibiotics and with defined macrolide resistance mechanisms were determined. The propensity of macrolones to induce the expression of inducible erm genes was tested by the triple-disk method and incubation in the presence of subinhibitory concentrations of compounds. In vivo efficacy was assessed in a murine model of S. pneumoniae-induced pneumonia, and pharmacokinetic (PK) profiles in mice were determined. The in vitro antibacterial profiles of macrolones were superior to those of marketed macrolide antibiotics, including the ketolide telithromycin, and the compounds did not induce the expression of inducible erm genes. They acted as typical protein synthesis inhibitors in an Escherichia coli transcription/translation assay. Macrolones were characterized by low to moderate systemic clearance, a large volume of distribution, a long half-life, and low oral bioavailability. They were highly efficacious in a murine model of pneumonia after intraperitoneal application even against an S. pneumoniae strain with constitutive resistance to macrolide-lincosamide-streptogramin B antibiotics. Macrolones are the class of macrolide antibiotics with an outstanding antibacterial profile and reasonable PK parameters resulting in good in vivo efficacy.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana/efeitos dos fármacos
Macrolídeos/farmacologia
Pneumonia Pneumocócica/tratamento farmacológico
Inibidores da Síntese de Proteínas/farmacologia
Streptococcus pneumoniae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacocinética
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Modelos Animais de Doenças
Farmacorresistência Bacteriana/genética
Escherichia coli/química
Haemophilus influenzae/efeitos dos fármacos
Haemophilus influenzae/crescimento & desenvolvimento
Cetolídeos/farmacologia
Lincosamidas/farmacologia
Macrolídeos/farmacocinética
Masculino
Metiltransferases/genética
Metiltransferases/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Pneumonia Pneumocócica/microbiologia
Biossíntese de Proteínas/efeitos dos fármacos
Inibidores da Síntese de Proteínas/farmacocinética
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/crescimento & desenvolvimento
Streptococcus pneumoniae/genética
Streptococcus pneumoniae/crescimento & desenvolvimento
Streptococcus pyogenes/efeitos dos fármacos
Streptococcus pyogenes/crescimento & desenvolvimento
Estreptogramina B/farmacologia
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Ketolides); 0 (Lincosamides); 0 (Macrolides); 0 (Protein Synthesis Inhibitors); 3131-03-1 (Streptogramin B); EC 2.1.1.- (Methyltransferases); EC 2.1.1.184 (ErmA protein, Bacteria); KI8H7H19WL (telithromycin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.00524-16


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[PMID]:27094233
[Au] Autor:Pereira JN; Rabelo MA; Lima JL; Neto AM; Lopes AC; Maciel MA
[Ad] Endereço:Department of Tropical Medicine, Universidade Federal de Pernambuco, Recife, PE, Brasil. Electronic address: ju-biomed@hotmail.com.
[Ti] Título:Phenotypic and molecular characterization of resistance to macrolides, lincosamides and type B streptogramin of clinical isolates of Staphylococcus spp. of a university hospital in Recife, Pernambuco, Brazil.
[So] Source:Braz J Infect Dis;20(3):276-81, 2016 May-Jun.
[Is] ISSN:1678-4391
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: There is a mechanism of macrolide resistance in Staphylococcus spp. which also affects the lincosamides and type B streptogramins characterizing the so-called MLSB resistance, whose expression can be constitutive (cMLSB) or inducible (iMLSB) and is encoded mainly by ermA and ermC genes. The cMLSB resistance is easily detected by susceptibility testing used in the laboratory routine, but iMLSB resistance is not. Therapy with clindamycin in cases of infection with isolated iMLSB resistance may fail. OBJECTIVE: To characterize the phenotypic (occurrence of cMLSB and iMLSB phenotypes) and molecular (occurrence of ermA and ermC genes) profiles of MLSB resistance of clinical isolates of susceptible and methicillin-resistant Staphylococcus aureus and CNS (coagulase-negative Staphylococcus) from patients of a university hospital, in Pernambuco. METHODS: The antimicrobial susceptibility of 103 isolates was determined by the disk diffusion technique in Mueller-Hinton agar followed by oxacillin screening. The iMLSB phenotype was detected by D test. Isolates with cMLSB and iMLSB phenotypes were subjected to polymerase chain reaction (PCR) for the detection of ermA and ermC genes. RESULTS: The cMLSB and iMLSB phenotypes were respectively identified in 39 (37.9%) and five (4.9%) isolates. The iMLSB phenotype was found only in four (10.8%) methicillin-susceptible S. aureus and one (4.5%) methicillin-resistant S. aureus. In the 44 isolates subjected to PCR, four (9.1%) only ermA gene was detected, a lower frequency when compared to only ermC 17 (38.6%) gene and to one (2.3%) isolate presenting both genes. CONCLUSION: In the Staphylococcus spp. analyzed, the ermC gene was found more often than the ermA, although the iMLSB phenotype had been less frequent than the cMLSB. It was important to perform the D test for its detection to guide therapeutic approaches.
[Mh] Termos MeSH primário: Farmacorresistência Bacteriana Múltipla/genética
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Staphylococcus/efeitos dos fármacos
Staphylococcus/genética
Estreptogramina B/farmacologia
[Mh] Termos MeSH secundário: Brasil
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Genes Bacterianos/genética
Hospitais Universitários
Seres Humanos
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lincosamides); 0 (Macrolides); 3131-03-1 (Streptogramin B)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE


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[PMID]:27045297
[Au] Autor:de Matos PD; de Oliveira TL; Cavalcante FS; Ferreira DC; Iorio NL; Pereira EM; Chamon RC; Dos Santos KR
[Ad] Endereço:1 Department of Medical Microbiology, Institute of Microbiology , Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil .
[Ti] Título:Molecular Markers of Antimicrobial Resistance in Methicillin-Resistant Staphylococcus aureus SCCmec IV Presenting Different Genetic Backgrounds.
[So] Source:Microb Drug Resist;22(8):700-706, 2016 Dec.
[Is] ISSN:1931-8448
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methicillin-resistant Staphylococcus aureus (MRSA) carrying SCCmec type IV has emerged in hospitals worldwide. The aim of this study was to evaluate phenotypic and molecular characteristics of antimicrobial resistance in MRSA SCCmec IV isolates, presenting different genetic backgrounds, isolated from hospitals in Rio de Janeiro. The antimicrobial resistance of 128 S. aureus type IV isolates from 11 hospitals was characterized by the disk diffusion test and minimum inhibitory concentration (MIC) test. Mutations in parC gene, which encodes ciprofloxacin resistance, and genes associated with macrolide-lincosamide-streptogramin B (MLS ) resistance were also investigated. MRSA isolates belonging to USA400/ST1 (60 isolates), USA800/ST5 (40), USA1100/ST30 (13), and other 11 (15) lineages were mainly resistant to erythromycin (68%), ciprofloxacin (56%), and clindamycin (50%). The highest antimicrobial resistance rates were found among USA400 isolates (p < 0.05). The majority of them (90%) carried only the erm(C) gene and mainly presented two mutation types in the parC gene. The msr(A) gene was most frequently found among USA800 isolates (p < 0.05). Among MRSA type IV isolates from Rio de Janeiro hospitals, multiresistance, including mutations in parC gene, was associated to the USA400/ST1, while the msr(A) gene was associated with USA800/ST5 isolates, highlighting that these lineages could have more potential to persist in a hospital environment.
[Mh] Termos MeSH primário: DNA Topoisomerase IV/genética
Farmacorresistência Bacteriana Múltipla/genética
Regulação Bacteriana da Expressão Gênica
Staphylococcus aureus Resistente à Meticilina/genética
Metionina Sulfóxido Redutases/genética
Metiltransferases/genética
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Técnicas de Tipagem Bacteriana
Brasil/epidemiologia
DNA Topoisomerase IV/metabolismo
Hospitais
Seres Humanos
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/crescimento & desenvolvimento
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Metionina Sulfóxido Redutases/metabolismo
Metiltransferases/metabolismo
Testes de Sensibilidade Microbiana
Epidemiologia Molecular
Mutação
Quinolonas/farmacologia
Infecções Estafilocócicas/tratamento farmacológico
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/microbiologia
Estreptogramina B/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Lincosamides); 0 (Macrolides); 0 (Quinolones); 3131-03-1 (Streptogramin B); EC 1.8.4.- (Methionine Sulfoxide Reductases); EC 1.8.4.11 (methionine sulfoxide reductase); EC 2.1.1.- (Methyltransferases); EC 2.1.1.230 (rRNA (adenosine-O-2'-)methyltransferase); EC 5.99.1.- (DNA Topoisomerase IV)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160406
[St] Status:MEDLINE


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[PMID]:26604242
[Au] Autor:Florez-Cuadrado D; Ugarte-Ruiz M; Quesada A; Palomo G; Domínguez L; Porrero MC
[Ad] Endereço:Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense de Madrid, Madrid, Spain.
[Ti] Título:Description of an erm(B)-carrying Campylobacter coli isolate in Europe.
[So] Source:J Antimicrob Chemother;71(3):841-3, 2016 Mar.
[Is] ISSN:1460-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Infecções por Campylobacter/veterinária
Campylobacter coli/efeitos dos fármacos
Campylobacter coli/genética
Farmacorresistência Bacteriana
Metiltransferases/genética
Doenças das Aves Domésticas/microbiologia
[Mh] Termos MeSH secundário: Animais
Infecções por Campylobacter/microbiologia
Campylobacter coli/isolamento & purificação
DNA Bacteriano/química
DNA Bacteriano/genética
Europa (Continente)
Ordem dos Genes
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Testes de Sensibilidade Microbiana
Estreptogramina B/farmacologia
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 0 (Lincosamides); 0 (Macrolides); 3131-03-1 (Streptogramin B); EC 2.1.1.- (Methyltransferases); EC 2.1.1.230 (rRNA (adenosine-O-2'-)methyltransferase)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151126
[St] Status:MEDLINE
[do] DOI:10.1093/jac/dkv383


  9 / 105 MEDLINE  
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[PMID]:26573051
[Au] Autor:Abdollahi S; Ramazanzadeh R; Khiabani ZD; Kalantar E
[Ad] Endereço:. atrop_t51@yahoo.com.
[Ti] Título:Epidemiological and Inducible Resistance in Coagulase Negative Staphylococci.
[So] Source:Glob J Health Sci;8(4):109-19, 2015 Jul 31.
[Is] ISSN:1916-9736
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & OBJECTIVES: Coagulase negative staphylococci (CNS) are potential pathogens with the increased use of implants in hospitals. Macrolide, lincosamide and streptogramin B (MLSB) are used in the treatment of staphylococcal infections. The aim of this study was to molecular detection of inducible clindamycin resistance and genetic pattern in CNS isolates and their transmission between hospitals. MATERIALS & METHODS: 110 CNS strains, isolated from hospitalized patients in the intensive care unit and infectious wards of Besat and Toohid hospitals, Sanandaj. Methicillin resistance was done by agar screen test and the resistance inducible Clindamycin by the D-Test. Multiplex PCR was performed, using primers specific for erm (A, B, C, and TR) genes. Diversity of strains was determined by ERIC-PCR technique based on the similarities between DNA fingerprints by using Jaccards coefficient in the SAHN program of the NTSYS-pc software. RESULTS: Of the 110 isolates, 64(58.2%) were methicillin -resistant CNS (MRCNS), 48(43.6%) were resistant to erythromycin (ERCNS). Out of 48 Erythromycin-resistant strains 5 (10.4%) were iMLS B phenotypes that 4 isolates showed genes erm by Multiplex PCR. The ERIC-PCR profiles allowed typing of the 110 isolates into 90 ERIC-types which were grouped into fourteen main clusters (C1-C14). CONCLUSION: The results of this study also showed that most of CNS isolated produced different genomic fingerprint patterns, therefore, source of infection is differen t.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Clindamicina/farmacologia
Infecções Estafilocócicas/tratamento farmacológico
Infecções Estafilocócicas/microbiologia
Staphylococcus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Coagulase
Infecção Hospitalar/microbiologia
Impressões Digitais de DNA
Farmacorresistência Bacteriana Múltipla
Seres Humanos
Unidades de Terapia Intensiva
Irã (Geográfico)/epidemiologia
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Staphylococcus aureus Resistente à Meticilina
Testes de Sensibilidade Microbiana
Fenótipo
Reação em Cadeia da Polimerase
Staphylococcus/classificação
Staphylococcus/isolamento & purificação
Estreptogramina B/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coagulase); 0 (Lincosamides); 0 (Macrolides); 3131-03-1 (Streptogramin B); 3U02EL437C (Clindamycin)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151118
[St] Status:MEDLINE
[do] DOI:10.5539/gjhs.v8n4p109


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[PMID]:26377866
[Au] Autor:Anastasi E; Giguère S; Berghaus LJ; Hondalus MK; Willingham-Lane JM; MacArthur I; Cohen ND; Roberts MC; Vazquez-Boland JA
[Ad] Endereço:Microbial Pathogenesis Unit, School of Biomedical Sciences and The Roslin Institute, University of Edinburgh, Edinburgh, UK.
[Ti] Título:Novel transferable erm(46) determinant responsible for emerging macrolide resistance in Rhodococcus equi.
[So] Source:J Antimicrob Chemother;70(12):3184-90, 2015 Dec.
[Is] ISSN:1460-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objective of this study was to identify the molecular mechanism of macrolide resistance in the actinomycete Rhodococcus equi, a major equine pathogen and zoonotic agent causing opportunistic infections in people. METHODS: Macrolide-resistant (n = 62) and macrolide-susceptible (n = 62) clinical isolates of R. equi from foals in the USA were studied. WGS of 18 macrolide-resistant and 6 macrolide-susceptible R. equi was performed. Representative sequences of all known macrolide resistance genes identified to date were used to search the genome assemblies for putative homologues. PCR was used to screen for the presence of the identified resistance determinant in the rest of the isolates. Mating experiments were performed to verify mobility of the gene. RESULTS: A novel erm gene, erm(46), was identified in all sequenced resistant isolates, but not in susceptible isolates. There was complete association between macrolide resistance and the presence of erm(46) as detected by PCR screening of all 124 clinical isolates of R. equi. Expression of erm(46) in a macrolide-susceptible strain of R. equi induced high-level resistance to macrolides, lincosamides and streptogramins B, but not to other classes of antimicrobial agents. Transfer of erm(46) to macrolide-susceptible R. equi was confirmed. The transfer frequency ranged from 3 × 10(-3) to 1 × 10(-2). CONCLUSIONS: This is the first molecular characterization of resistance to macrolides, lincosamides and streptogramins B in R. equi. Resistance was due to the presence of a novel erm(46) gene mobilizable likely by conjugation, which has spread among equine isolates of R. equi in the USA.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana
Transferência Genética Horizontal
Genes Bacterianos
Macrolídeos/farmacologia
Rhodococcus equi/efeitos dos fármacos
Rhodococcus equi/genética
[Mh] Termos MeSH secundário: Infecções por Actinomycetales/microbiologia
Infecções por Actinomycetales/veterinária
Animais
Animais Recém-Nascidos
Conjugação Genética
DNA Bacteriano/química
DNA Bacteriano/genética
Doenças dos Cavalos/microbiologia
Cavalos
Lincosamidas/farmacologia
Rhodococcus equi/isolamento & purificação
Análise de Sequência de DNA
Estreptogramina B/farmacologia
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 0 (Lincosamides); 0 (Macrolides); 3131-03-1 (Streptogramin B)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150918
[St] Status:MEDLINE
[do] DOI:10.1093/jac/dkv279



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